Scientists may have found a popular fruit that has a profound and positive effect in the prevention and treatment of prostate cancer, some studies suggested.
Prostate cancer is a medical and chronic disease characterized by cells growth disorderly and uncontrollably in the tissue of prostate gland. At the later stage, cancerous cells may travel a distance away from the prostate gland to infect other healthy tissue and organs.
According to a statistic in the US, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases out of 10 diagnosed with the condition are men aged 65 or older.
In 2017, 21,300 men in Canada were diagnosed with prostate cancer which represents 21% of all new cancer cases in men. And 4,100 men died from the disease(4).
Although Inherited mutations such as BRCA1 and BRCA2 that cause abnormal cell growth in the prostate gland are considered a major cause of prostate cancer, Acquired gene mutations such as overproduction of androgens (male hormones) gene that promotes prostate cell growth also contribute to prostate cancer risk in some men.
However, over years of studies also suggested that increases of age, ethnic group, family history, obesity, environment chemical,.... and unhealthy diet also have a strong implication in induction to the onset of prostate cancer.
Due to the slow progression of the disease, most patients do not experience any symptoms until the advanced stage. Most common symptoms including blood in the urine (hematuria), burning or pain during urination, difficulty urinating, decreased flow or velocity of urine stream, ......more frequent urges to urinate at night.
In some cases, patients may also be a loss of bladder control.
If you experience some of the above symptoms, please check with your doctor immediately to rule out the possibility.
Avocados are a commercially valuable fruit cultivated in tropical climates throughout the world.
The fruit has a green-skinned, pear-shaped fruit that ripens after harvesting, native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol; fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B(a).
According to the Case-control study of 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men attending the same urology clinics conducted by the University of the West Indie, intake of dietary MUFA from whole fruit of avocado are associated to reduced risk and treatment of prostate cancer(1).
Dr. Jackson MD, the lead scientist said, "Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes. High blood linolenic acid was directly related to prostate cancer" and " Dietary intakes of other fats were not associated with PCa"(1).
The University of California study showed that the anti-prostate cancer effects of avocado are not attributed to a single ingredient such as carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein but the interaction of all ingredients in the whole fruit in combination with other diet-derived phytochemicals(2).
The study suggested, intake of avocado stimulated the increase production of increase in p27 protein which involves function as tumor suppressor in controlling the cell cycle progression, in incubated PC-3 cells(2)
Avocado induced PC- 3 cancer cell death through cells apoptosis through G(2)/M cell cycle arrest the study continued(2).
In the evaluation of the effect of the anticancer of avocado conducted by the Purdue University study also showed a positive effect of the whole fruit in inhibition of six human tumor cell lines in culture, including human prostate adenocarcinoma (PC-3) cells(3).
The newly isolated Compounds 3 form of avocado containing g 1,2,4-triol moiety and a long aliphatic chain that terminates as either an alkane, alkene, or alkyne, respectively, exerted the strongest activity against PC-3 comparable to adriamycin, an anti-cancer conventional medicine(3).
Furthermore, when tested against yellow fever mosquito larva, the 3 form avocado also was more effective than rotenone, a natural botanical insecticide(3).
Therefore, men who are at high risk of prostate cancer may want to add a portion of avocado into their daily diet for preventive measure.
Taken altogether, avocado with abundant carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein may be considered a functional food for the prevention and treatment of prostate cancer.
However, additional large sample size and multicenter clinical trials with human consumption during the course of the disease are necessary to reconfirm avocado anti-prostate cancer possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Perseaamericana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
(4) Prostate cancer statistics, Canadian Cancer Society
12. Avocado and Skin health
13. Avocado and Cadiovascular diseases
Saturday, December 1, 2018
Friday, November 30, 2018
Caffeinated Coffee, The Liver Protective and Anti Non Alcoholic Liver Disease Beverage
Habitual caffeinated coffee intake may have a potential of curing Non-Alcoholic Liver Disease, some scientists found.
Non-alcohol fatty liver disease (NAFLD) is a chronic medical condition of the fatty liver caused by excessive fat deposited (steatosis) in the liver other than over-consumption of alcohol.
The disease is a common liver disorder found in most developed countries, probably due to over-consumption of carbohydrates which are considered as a major stimulus for hepatic de novo lipogenesis (DNL), the esterification of plasma free fatty acids, such as American diet.
According to a clinical assessment conducted by the joint study led by the Global Clinical Research, " Hepatic de novo lipogenesis(DNL), the synthesis of new fatty acids from non-lipid sources, is thought to play a pivotal role in the development of NAFLD"(4).
In compared to lipids that were defined as soluble substances in organic solvents, including the various types of fatty acids, eicosanoids, fatty alcohols, fatty aldehydes, ...... and hydrocarbons, fatty acids from non-lipid sources are men make substances that do not rely on organic solvents, but use other chemicals to separate the lipids from the rest of the food, including buttermilk fat, beef fat (tallow, suet), chicken fa,t cream pork fat, (lard),... and stick margarine
Dr. Paglialunga S. the lead author suggested as of today, there is no NAFLD-specific therapeutic agent available. However, pharmaceutical drugs aimed at reducing hepatic fat accretion may prove to be a powerful ally in the treatment and management of this disease(4).
Some researchers also said a chronic metabolic derangement referred to steatosis are directly associated with patients with obesity and type 2 diabetes(4).
According to the statistic, approximately, 80 millions of US adults suffer from Non-alcoholic fatty liver disease (NAFLD) in which 30% to 40% of those patients show no visible signs and symptoms.
However, most patients with Non-Alcoholic Liver Disease may experience signs and symptoms of abdominal swelling, enlarged blood vessels just beneath the skin's surface, spleen, red palms,.... and jaundice as a result of liver advanced scarring (steatohepatitis and cirrhosis).
If you have some of the above symptoms, please see your doctor right the way to rule out the possibility.
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to a retrospective cross-sectional study on patients with non-alcoholic fatty liver disease (NAFLD), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection to determine the effects of coffee intake on a non-invasive marker of liver fibrosis, coffee intake of 2 or more cups per day demonstrated a significant reduced liver symptom of stiffness, after adjustment for age, gender, smoking, alcohol consumption, in compared to other subgroups.
Additionally, in the review of epidemiological and clinical evidence by the Zhejiang University, researchers suggested coffee intake may have a profoundly reduced severity and risk of non-alcoholic fatty liver disease (NAFLD) prevalence.
In fact, the effect of coffee on attenuated risk of non-alcoholic fatty liver disease (NAFLD) incidence may be also involved other chemical constituents other than caffeine.
Dr. Chen S, the lead researchers suggested that said, "Several possible mechanisms underlying coffee's hepatoprotective effects in NAFLD include antioxidative, anti-inflammatory, and antifibrotic effects".
Interestingly, the review of literature published in the database of Medline and Embase up to March 2015, showed that coffee and coffee caffeine intake have a strong impact in protecting the liver against complications of fibrosis incidence.
Information collected indicated that coffee and coffee caffeine intake have an enormous demonstration in ameliorated risk and symptoms of Nonalcoholic liver disease, but some researchers suggested that other components may also play an important role in the enhancement of these results.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee Intake Is Associated with a Lower Liver Stiffness in Patients with Non-Alcoholic Fatty Liver Disease, Hepatitis C, and Hepatitis B by Hodge A1,2, Lim S3, Goh E4, Wong O5, Marsh P6, Knight V7, Sievert W8,9, de Courten B10.(PubMed)
(2) Coffee and non-alcoholic fatty liver disease: brewing evidence for hepatoprotection? by Chen S1, Teoh NC, Chitturi S, Farrell GC.(PubMed)
(3) Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies by Marventano S1, Salomone F2, Godos J3, Pluchinotta F4, Del Rio D5, Mistretta A1, Grosso G6.(PubMed)
(4) Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease by Sabina Paglialunga
1 and Clayton A. Dehn(PubMed)
Non-alcohol fatty liver disease (NAFLD) is a chronic medical condition of the fatty liver caused by excessive fat deposited (steatosis) in the liver other than over-consumption of alcohol.
The disease is a common liver disorder found in most developed countries, probably due to over-consumption of carbohydrates which are considered as a major stimulus for hepatic de novo lipogenesis (DNL), the esterification of plasma free fatty acids, such as American diet.
According to a clinical assessment conducted by the joint study led by the Global Clinical Research, " Hepatic de novo lipogenesis(DNL), the synthesis of new fatty acids from non-lipid sources, is thought to play a pivotal role in the development of NAFLD"(4).
In compared to lipids that were defined as soluble substances in organic solvents, including the various types of fatty acids, eicosanoids, fatty alcohols, fatty aldehydes, ...... and hydrocarbons, fatty acids from non-lipid sources are men make substances that do not rely on organic solvents, but use other chemicals to separate the lipids from the rest of the food, including buttermilk fat, beef fat (tallow, suet), chicken fa,t cream pork fat, (lard),... and stick margarine
Dr. Paglialunga S. the lead author suggested as of today, there is no NAFLD-specific therapeutic agent available. However, pharmaceutical drugs aimed at reducing hepatic fat accretion may prove to be a powerful ally in the treatment and management of this disease(4).
Some researchers also said a chronic metabolic derangement referred to steatosis are directly associated with patients with obesity and type 2 diabetes(4).
According to the statistic, approximately, 80 millions of US adults suffer from Non-alcoholic fatty liver disease (NAFLD) in which 30% to 40% of those patients show no visible signs and symptoms.
However, most patients with Non-Alcoholic Liver Disease may experience signs and symptoms of abdominal swelling, enlarged blood vessels just beneath the skin's surface, spleen, red palms,.... and jaundice as a result of liver advanced scarring (steatohepatitis and cirrhosis).
If you have some of the above symptoms, please see your doctor right the way to rule out the possibility.
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to a retrospective cross-sectional study on patients with non-alcoholic fatty liver disease (NAFLD), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection to determine the effects of coffee intake on a non-invasive marker of liver fibrosis, coffee intake of 2 or more cups per day demonstrated a significant reduced liver symptom of stiffness, after adjustment for age, gender, smoking, alcohol consumption, in compared to other subgroups.
Additionally, in the review of epidemiological and clinical evidence by the Zhejiang University, researchers suggested coffee intake may have a profoundly reduced severity and risk of non-alcoholic fatty liver disease (NAFLD) prevalence.
In fact, the effect of coffee on attenuated risk of non-alcoholic fatty liver disease (NAFLD) incidence may be also involved other chemical constituents other than caffeine.
Dr. Chen S, the lead researchers suggested that said, "Several possible mechanisms underlying coffee's hepatoprotective effects in NAFLD include antioxidative, anti-inflammatory, and antifibrotic effects".
Interestingly, the review of literature published in the database of Medline and Embase up to March 2015, showed that coffee and coffee caffeine intake have a strong impact in protecting the liver against complications of fibrosis incidence.
Information collected indicated that coffee and coffee caffeine intake have an enormous demonstration in ameliorated risk and symptoms of Nonalcoholic liver disease, but some researchers suggested that other components may also play an important role in the enhancement of these results.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee Intake Is Associated with a Lower Liver Stiffness in Patients with Non-Alcoholic Fatty Liver Disease, Hepatitis C, and Hepatitis B by Hodge A1,2, Lim S3, Goh E4, Wong O5, Marsh P6, Knight V7, Sievert W8,9, de Courten B10.(PubMed)
(2) Coffee and non-alcoholic fatty liver disease: brewing evidence for hepatoprotection? by Chen S1, Teoh NC, Chitturi S, Farrell GC.(PubMed)
(3) Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies by Marventano S1, Salomone F2, Godos J3, Pluchinotta F4, Del Rio D5, Mistretta A1, Grosso G6.(PubMed)
(4) Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease by Sabina Paglialunga
1 and Clayton A. Dehn(PubMed)Thursday, November 29, 2018
The Herbal Tea That Works Better Than Sleeping Pills, With No Side Effects, Scientists Said
Intake of chamomile may have a strong and positive effect in prevented and treated insomnia, some scientists suggested.
Insomnia is a chronic sleep disorder characterized by difficulty of falling asleep and/or staying asleep. The condition affects most of the population of older adults due to hormones change that is associated with aging.
Most adults have experienced insomnia sometimes in their life. According to statistic, more than 30% of the population suffers from insomnia, one in three people suffer from some form of insomnia during their lifetime and women suffer from insomnia more often than men.
Some researchers suggested that psychiatric and medical conditions, unhealthy sleep habits, and in a healthy diet and lifestyle, particularly in use of substances, and/or certain biological factors are major causes of insomnia onset.
Some women in certain stages of the menstrual cycle also suffer from this type of sleep disorder, due to the body inability to cope with the sudden change of hormone production. Needless to say, insomnia that is caused by menstrual pain. According to the National Sleep Foundation poll, 33% of women said, their sleep is disturbed during their menstrual cycles.
In Australia, according to statistic produced by Virtual Medical Center, "Almost 90% of Australians suffer from a sleeping disorder, with 30% experiencing a severe sleeping disorder" and "There are over 70 different defined sleep disorders which result in reduced sleep quantity or reduced sleep quality"(4).
Poor sleep quality in patients who suffer from insomnia may induce symptoms of fatigue, irritability, decreased memory and concentration,..... and malaise.
These results truly have a strongly negative impact on quality of life and work life, resulting in decreasing productivity and increased absenteeism.
Use of sleep pill to treat insomnia may be effective, however, according to the Additive Center, "The dangerous effects of sleep medications range from seizures to depressed breathing. Some people also experience allergic reactions from sleeping pills that can cause difficulty breathing, chest pain, nausea and swelling" and "Though rare, people who use sleeping pills may even develop parasomnias. Parasomnias are defined as sleep disorders that include behaviors like sleep-walking, sleep-eating, sleep-sex, sleep-driving, and other potentially dangerous sleep-related activities"(5).
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas,..... and bloating in the intestine.
Ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).
Chamomile, is one of the most popular herb used for sleep disorders in herbal medicine.
According to the Dr. Srivastava JK and research team at the Case Western Reserve University, in the investigation of The dried flowers of chamomile containing many terpenoids and flavonoids that may contribute to its medicinal properties, found that, injection in form of herbal tea, consumed more than one million cups per day worldwide, may have a significant impact in the treatment of insomnia(1).
In the concerns of chamomile's (Matricaria recutita) efficacy and safety for treating chronic primary insomnia, scientists at the University of Michigan conducted an experiment of 34 patients aged 18-65 years with DSM-IV primary insomnia for ≥ 6-months, showed that application of 270 mg of chamomile twice daily or placebo for 28-days exerts a modest benefits of daytime functioning and mixed benefits on sleep diary(2).
Dr. Zick SM, the lead author at the end of the evaluation, said, "Chamomile did show a modest advantage on daytime functioning, although these did not reach statistical significance. Effect sizes were generally small to moderate (Cohen's d ≤ 0.20 to < 0.60) with sleep latency, nighttime awakenings, and Fatigue Severity Scale (FSS), having moderate effect sizes in favor of chamomile"(2).
The efficacy of chamomile in the treatment of insomnia may also be attributed to the anxiolytic or sedative properties in the improvement of sleep, according to the study of traditionally endowed with anxiolytic or sedative properties,(3).
However, Dr. Wheatley D suggested, " it's slow onset of effect (2-3 weeks) renders it unsuitable for short-term use (i.e. 'jet-lag'), but it does have profound beneficial effects on sleep architecture (augments deep sleep) that may make it particularly suitable for long-term use and for the elderly"(3).
The findings suggested that chamomile may be used as a functional food to improve insomnia due to the procession of anxiolytic or sedative properties.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA.(PubMed)
(1a) Anxiety disorder(Canadian mental health association)
(1) Chamomile: A herbal medicine of the past with bright future by Srivastava JK1, Shankar E, Gupta S.(PubMed)
(2) Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study by Zick SM1, Wright BD, Sen A, Arnedt JT.(PubMed)
(3) Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. by Wheatley D.(PubMed)
(4) Insomnia by Virtual Medical Center
Insomnia is a chronic sleep disorder characterized by difficulty of falling asleep and/or staying asleep. The condition affects most of the population of older adults due to hormones change that is associated with aging.
Most adults have experienced insomnia sometimes in their life. According to statistic, more than 30% of the population suffers from insomnia, one in three people suffer from some form of insomnia during their lifetime and women suffer from insomnia more often than men.
Some researchers suggested that psychiatric and medical conditions, unhealthy sleep habits, and in a healthy diet and lifestyle, particularly in use of substances, and/or certain biological factors are major causes of insomnia onset.
Some women in certain stages of the menstrual cycle also suffer from this type of sleep disorder, due to the body inability to cope with the sudden change of hormone production. Needless to say, insomnia that is caused by menstrual pain. According to the National Sleep Foundation poll, 33% of women said, their sleep is disturbed during their menstrual cycles.
In Australia, according to statistic produced by Virtual Medical Center, "Almost 90% of Australians suffer from a sleeping disorder, with 30% experiencing a severe sleeping disorder" and "There are over 70 different defined sleep disorders which result in reduced sleep quantity or reduced sleep quality"(4).
Poor sleep quality in patients who suffer from insomnia may induce symptoms of fatigue, irritability, decreased memory and concentration,..... and malaise.
These results truly have a strongly negative impact on quality of life and work life, resulting in decreasing productivity and increased absenteeism.
Use of sleep pill to treat insomnia may be effective, however, according to the Additive Center, "The dangerous effects of sleep medications range from seizures to depressed breathing. Some people also experience allergic reactions from sleeping pills that can cause difficulty breathing, chest pain, nausea and swelling" and "Though rare, people who use sleeping pills may even develop parasomnias. Parasomnias are defined as sleep disorders that include behaviors like sleep-walking, sleep-eating, sleep-sex, sleep-driving, and other potentially dangerous sleep-related activities"(5).
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas,..... and bloating in the intestine.
Ingredients
Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).
Chamomile, is one of the most popular herb used for sleep disorders in herbal medicine.
According to the Dr. Srivastava JK and research team at the Case Western Reserve University, in the investigation of The dried flowers of chamomile containing many terpenoids and flavonoids that may contribute to its medicinal properties, found that, injection in form of herbal tea, consumed more than one million cups per day worldwide, may have a significant impact in the treatment of insomnia(1).
In the concerns of chamomile's (Matricaria recutita) efficacy and safety for treating chronic primary insomnia, scientists at the University of Michigan conducted an experiment of 34 patients aged 18-65 years with DSM-IV primary insomnia for ≥ 6-months, showed that application of 270 mg of chamomile twice daily or placebo for 28-days exerts a modest benefits of daytime functioning and mixed benefits on sleep diary(2).
Dr. Zick SM, the lead author at the end of the evaluation, said, "Chamomile did show a modest advantage on daytime functioning, although these did not reach statistical significance. Effect sizes were generally small to moderate (Cohen's d ≤ 0.20 to < 0.60) with sleep latency, nighttime awakenings, and Fatigue Severity Scale (FSS), having moderate effect sizes in favor of chamomile"(2).
The efficacy of chamomile in the treatment of insomnia may also be attributed to the anxiolytic or sedative properties in the improvement of sleep, according to the study of traditionally endowed with anxiolytic or sedative properties,(3).
However, Dr. Wheatley D suggested, " it's slow onset of effect (2-3 weeks) renders it unsuitable for short-term use (i.e. 'jet-lag'), but it does have profound beneficial effects on sleep architecture (augments deep sleep) that may make it particularly suitable for long-term use and for the elderly"(3).
The findings suggested that chamomile may be used as a functional food to improve insomnia due to the procession of anxiolytic or sedative properties.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA.(PubMed)
(1a) Anxiety disorder(Canadian mental health association)
(1) Chamomile: A herbal medicine of the past with bright future by Srivastava JK1, Shankar E, Gupta S.(PubMed)
(2) Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study by Zick SM1, Wright BD, Sen A, Arnedt JT.(PubMed)
(3) Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. by Wheatley D.(PubMed)
(4) Insomnia by Virtual Medical Center
Wednesday, November 28, 2018
Calendula (Calendula officinalis), The Herb That Cuts Off the Energy Supply to Cancers
Herbal calendula may process a profound and sustainable effect in inhibiting the key step in tumor angiogenesis, some scientists suggested.
Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells growth and proliferation.
Cancers are the class of diseases caused by alternation of DNA that initiates healthy cells to grow disorderly and uncontrollably.
At the later stage, the cancerous cells may travel a distance away from the original site to infect healthy cells of other tissue and organs.
Cancers are the second leading cause of death worldwide besides heart diseases.
According to a statistic from the Canada Government, approximately 1 in 2 Canadians will be diagnosed with cancer during their lifetime, and 1 in 4 will die from the disease.
Most common types of cancer in Canada include lung, colorectal, breast and prostate cancers. And these 4 cancers are account for half of all cancers diagnosed in Canada.
Believe or not, 1/4 of cancers death are due to lung cancer.
Depending on types of cancer, people with cancers may experience general and specific symptoms.
The American Cancer Society wrote, "Cancer may also cause symptoms like fever, extreme tiredness (fatigue), or weight loss. Because cancer cells use up much of the body’s energy supply, or they may release substances that change the way the body makes energy from food. Cancer can also cause the immune system to react in ways that produce these signs and symptoms" and " Sometimes, cancer cells release substances into the bloodstream that cause symptoms that are not usually linked to cancer. For example, some cancers of the pancreas can release substances that cause blood clots in veins of the legs".
DNA alternation is the major cause of the diseases.
Some researchers suggested smoking, radiation, viruses, carcinogens, obesity, hormones, chronic inflammation,.... and physical inactivity are associated with increased risk of cancers.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belongings to the family Asteraceae, native to Southern Europe.
The herb has been used in traditional medicine as spasmolytic, spasmogenic, inflammatory agent and to treat abdominal cramps, wound healing, skin diseases, colitis,.... and constipation.
Chemicals Compounds
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin,.... and n-paraffins.
The study of Calendula against the Angiogenesis of most solid tumors suggested that calendula consists of a strong and positive effect in suppressed tumors growth through its anti infectiously endothelial cells proliferation(1).
Application of calendula extract also displayed antiangiogenic activity through a direct inhibitory activity against the key step in tumor angiogenesis(1).
Furthermore, according to Universidad de Granada, the extract exhibited cytotoxic tumor cell activity, induced lymphocyte activation in vivo against tumor growth of Ando-2 melanoma cells and prolonged the survival days of the mice, through cell cycle arrest in G0/G1 phase and Caspase-3-induced apoptosis(2).
Caspase 3 is one of a member of caspases that acts as a crucial mediator in programmed cell death (apoptosis).
On lung metastasis by B16F-10 melanoma cells in C57BL/6 mice, calendula officinalis flower extract reduced the lung tumor nodules by 74% with 43.3% increase in lifespan, probably through the inhibition of key enzymes involved in processes of metastasis(3).
These results suggested that herbal calendula officinalis and its extracts processed cytotoxic activity in the induction of tumor cells apoptosis by blocking cancer in facilitated growth, invasion, and metastasis.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of herbal calendula anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)
Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells growth and proliferation.
Cancers are the class of diseases caused by alternation of DNA that initiates healthy cells to grow disorderly and uncontrollably.
At the later stage, the cancerous cells may travel a distance away from the original site to infect healthy cells of other tissue and organs.
Cancers are the second leading cause of death worldwide besides heart diseases.
According to a statistic from the Canada Government, approximately 1 in 2 Canadians will be diagnosed with cancer during their lifetime, and 1 in 4 will die from the disease.
Most common types of cancer in Canada include lung, colorectal, breast and prostate cancers. And these 4 cancers are account for half of all cancers diagnosed in Canada.
Believe or not, 1/4 of cancers death are due to lung cancer.
Depending on types of cancer, people with cancers may experience general and specific symptoms.
The American Cancer Society wrote, "Cancer may also cause symptoms like fever, extreme tiredness (fatigue), or weight loss. Because cancer cells use up much of the body’s energy supply, or they may release substances that change the way the body makes energy from food. Cancer can also cause the immune system to react in ways that produce these signs and symptoms" and " Sometimes, cancer cells release substances into the bloodstream that cause symptoms that are not usually linked to cancer. For example, some cancers of the pancreas can release substances that cause blood clots in veins of the legs".
DNA alternation is the major cause of the diseases.
Some researchers suggested smoking, radiation, viruses, carcinogens, obesity, hormones, chronic inflammation,.... and physical inactivity are associated with increased risk of cancers.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belongings to the family Asteraceae, native to Southern Europe.
The herb has been used in traditional medicine as spasmolytic, spasmogenic, inflammatory agent and to treat abdominal cramps, wound healing, skin diseases, colitis,.... and constipation.
Chemicals Compounds
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin,.... and n-paraffins.
The study of Calendula against the Angiogenesis of most solid tumors suggested that calendula consists of a strong and positive effect in suppressed tumors growth through its anti infectiously endothelial cells proliferation(1).
Application of calendula extract also displayed antiangiogenic activity through a direct inhibitory activity against the key step in tumor angiogenesis(1).
Furthermore, according to Universidad de Granada, the extract exhibited cytotoxic tumor cell activity, induced lymphocyte activation in vivo against tumor growth of Ando-2 melanoma cells and prolonged the survival days of the mice, through cell cycle arrest in G0/G1 phase and Caspase-3-induced apoptosis(2).
Caspase 3 is one of a member of caspases that acts as a crucial mediator in programmed cell death (apoptosis).
On lung metastasis by B16F-10 melanoma cells in C57BL/6 mice, calendula officinalis flower extract reduced the lung tumor nodules by 74% with 43.3% increase in lifespan, probably through the inhibition of key enzymes involved in processes of metastasis(3).
These results suggested that herbal calendula officinalis and its extracts processed cytotoxic activity in the induction of tumor cells apoptosis by blocking cancer in facilitated growth, invasion, and metastasis.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of herbal calendula anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)
Tuesday, November 27, 2018
Coffee Lovers: Beware of Adverse Effect of Bladder Cancer's Risk
Coffee consumption may have a strong association to potential risk of bladder cancer development,
some scientists suggested.
Bladder cancer is a medical condition of cell growth irregularly and disorderly in the bladder. Cancer may spread to distant tissues and organs in the later stage.
Depending on the originated and infected tissue, bladder cancer can be classified into 3 types(4), including
* Transitional cell carcinoma
In the early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder beginning in cells in the lining of the bladder.
* Squamous cell carcinoma
Cancer begins in squamous cells in the found in the tissues of the surface of the bladder, due to long-term infection or irritation
* Adenocarcinoma
Cancer begins originates in the glandular tissue of the bladder, including the surface layer of skin, glands and a variety of other tissue, due to long-term irritation and inflammation.
Deepening to the stage, patients with bladder can may experience some of the below symptoms, bladder spasms, blood in urine, frequent urination, pain or burning sensation during urination, pain in lower back and/or abdomen, reduced bladder capacity, difficulty in urination,.... and common symptoms of loss of appetite and weight.
If you experience some of the symptoms above, please check with your doctor right the way.
Although the single cause of bladder cancer is still debatable, some scientists suggested that smoking,
chemicals exposure, a diet high in fried meats and fat, aging are substantial risk factors in the development of bladder cancer.
According to statistic
* Bladder cancer is the ninth most common cancer in the world.
* Every year over 430,000 new cases are diagnosed in 2012. And
* Men are 4 times more likely to develop bladder cancer in compared to women.
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the Shandong University, in the review literature published online satisfied the criteria and guideline to investigate the risk of bladder cancer among coffee consumption adults. Selected studies, numbers of cups/day and relative risk RR as follow
For 23 case-control studies
1. for 1 cup/day, RR=1.07
2 for 2 cups/day, RR=1.15
3 for 3 cups/day, RR=1.22
4. for 4 cups/day RR= 1.29
and
For 5 cohort studies
1. for 1 cup/day, RR=1.09
2. for 2 cups/day, RR=1.13
3. for 3 cups/day, RR= 1.09
4 for 4 cups/day, RR=1.01
The findings in both case-control and cohort studies showed a positive association of coffee intake and risk of bladder cancer.
In nonsmokers, according to the pooled dataset comprises 564 cases and 2929 hospital or population controls enrolled in ten studies conducted in Denmark, Germany, Greece, France, Italy, and Spain. risk of bladder cancer did not increase monotonically with dose but for heavy coffee drinkers of over 10 cups per days, the risk bladder cancer increases substantially.
Dr. Sala M, the lead author said, "Nonsmokers who are heavy coffee drinkers may have a small excess risk of bladder cancer".
Other, in analyzed a case-control study in two different areas of northern Italy (555 cases and 855 controls), coffee intake and risk of bladder cancer showed that
in compared to nondrinkers (RR: relative risk ratio)
1. RR 1.2 for one cup of coffee per day,
2. RR 1.4 for two,
3. RR 1.5 for three and
4 RR 1.4 for four or more
5. RR 1.5 (0.9-2.4) for decaffeinated coffee.
But in never smoked participants, the risk of bladder cancer increased significantly
1.RR 1.9 for one or two cups per day,
2. RR 1.8 for three and
3 RR 1.5 for four or more
Taking together, there is no doubt that coffee and coffee caffeine consumption have a mild risk in the exhibited incidence of bladder cancer regardless of numbers of cups intake daily and regularly.
However, Due to the small size of the studies, some researchers suggested that a sample size of a clinical trial with multi-centers involved are necessary to rule out or reconfirm the side effect of coffee intake possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A dose-response meta-analysis of coffee consumption and bladder cancer by Zhou Y1, Tian C, Jia C.(PubMed)
(2) Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case-control studies in European countries by Sala M1, Cordier S, Chang-Claude J, Donato F, Escolar-Pujolar A, Fernandez F, González CA, Greiser E, Jöckel KH, Lynge E, Mannetje A, Pohlabeln H, Porru S, Serra C, Tzonou A, Vineis P, Wahrendorf J, Boffetta P, Kogevina M.(PubMed)
(3) Coffee consumption and bladder cancer risk by D'Avanzo B1, La Vecchia C, Franceschi S, Negri E, Talamini R, Buttino I.(PubMed)
(4) Bladder Cancer by Kyle J. Norton
some scientists suggested.
Bladder cancer is a medical condition of cell growth irregularly and disorderly in the bladder. Cancer may spread to distant tissues and organs in the later stage.
Depending on the originated and infected tissue, bladder cancer can be classified into 3 types(4), including
* Transitional cell carcinoma
In the early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder beginning in cells in the lining of the bladder.
* Squamous cell carcinoma
Cancer begins in squamous cells in the found in the tissues of the surface of the bladder, due to long-term infection or irritation
* Adenocarcinoma
Cancer begins originates in the glandular tissue of the bladder, including the surface layer of skin, glands and a variety of other tissue, due to long-term irritation and inflammation.
Deepening to the stage, patients with bladder can may experience some of the below symptoms, bladder spasms, blood in urine, frequent urination, pain or burning sensation during urination, pain in lower back and/or abdomen, reduced bladder capacity, difficulty in urination,.... and common symptoms of loss of appetite and weight.
If you experience some of the symptoms above, please check with your doctor right the way.
Although the single cause of bladder cancer is still debatable, some scientists suggested that smoking,
chemicals exposure, a diet high in fried meats and fat, aging are substantial risk factors in the development of bladder cancer.
According to statistic
* Bladder cancer is the ninth most common cancer in the world.
* Every year over 430,000 new cases are diagnosed in 2012. And
* Men are 4 times more likely to develop bladder cancer in compared to women.
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to the Shandong University, in the review literature published online satisfied the criteria and guideline to investigate the risk of bladder cancer among coffee consumption adults. Selected studies, numbers of cups/day and relative risk RR as follow
For 23 case-control studies
1. for 1 cup/day, RR=1.07
2 for 2 cups/day, RR=1.15
3 for 3 cups/day, RR=1.22
4. for 4 cups/day RR= 1.29
and
For 5 cohort studies
1. for 1 cup/day, RR=1.09
2. for 2 cups/day, RR=1.13
3. for 3 cups/day, RR= 1.09
4 for 4 cups/day, RR=1.01
The findings in both case-control and cohort studies showed a positive association of coffee intake and risk of bladder cancer.
In nonsmokers, according to the pooled dataset comprises 564 cases and 2929 hospital or population controls enrolled in ten studies conducted in Denmark, Germany, Greece, France, Italy, and Spain. risk of bladder cancer did not increase monotonically with dose but for heavy coffee drinkers of over 10 cups per days, the risk bladder cancer increases substantially.
Dr. Sala M, the lead author said, "Nonsmokers who are heavy coffee drinkers may have a small excess risk of bladder cancer".
Other, in analyzed a case-control study in two different areas of northern Italy (555 cases and 855 controls), coffee intake and risk of bladder cancer showed that
in compared to nondrinkers (RR: relative risk ratio)
1. RR 1.2 for one cup of coffee per day,
2. RR 1.4 for two,
3. RR 1.5 for three and
4 RR 1.4 for four or more
5. RR 1.5 (0.9-2.4) for decaffeinated coffee.
But in never smoked participants, the risk of bladder cancer increased significantly
1.RR 1.9 for one or two cups per day,
2. RR 1.8 for three and
3 RR 1.5 for four or more
Taking together, there is no doubt that coffee and coffee caffeine consumption have a mild risk in the exhibited incidence of bladder cancer regardless of numbers of cups intake daily and regularly.
However, Due to the small size of the studies, some researchers suggested that a sample size of a clinical trial with multi-centers involved are necessary to rule out or reconfirm the side effect of coffee intake possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A dose-response meta-analysis of coffee consumption and bladder cancer by Zhou Y1, Tian C, Jia C.(PubMed)
(2) Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case-control studies in European countries by Sala M1, Cordier S, Chang-Claude J, Donato F, Escolar-Pujolar A, Fernandez F, González CA, Greiser E, Jöckel KH, Lynge E, Mannetje A, Pohlabeln H, Porru S, Serra C, Tzonou A, Vineis P, Wahrendorf J, Boffetta P, Kogevina M.(PubMed)
(3) Coffee consumption and bladder cancer risk by D'Avanzo B1, La Vecchia C, Franceschi S, Negri E, Talamini R, Buttino I.(PubMed)
(4) Bladder Cancer by Kyle J. Norton
Sunday, November 25, 2018
Alfalfa, The Anti Microbial Herbal Remedy
Alfalfa may be a potential antimicrobial agent used for the treatment of infection or infectious related diseases.
The microorganism, first observed by Anton van Leeuwenhoek in 1675 is a class of microscopic organism, including a bacterium, virus, or fungus.
Believe or not, single-celled like bacteria, algae, and protozoa, or multicellular, such as algae and fungi can survive under all types of extreme environment.
And less than 1% of bacteria, can invade and cause infection and diseases.
Although the discovery of human antibiotics is medicines that kill or slow the growth of bacteria, however, over uses of the antibiotics have been found to induce microbial resistance to certain drugs.
Dr. Jose M. Munita, the lead author in the study of " Mechanisms of Antibiotic Resistance" said, "Emergence of resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide" and " The bacterial response to the antibiotic “attack” is the prime example of bacterial adaptation and the pinnacle of evolution. “Survival of the fittest” is a consequence of an immense genetic plasticity of bacterial pathogens that trigger specific responses that result in mutational adaptations, acquisition of genetic material or alteration of gene expression producing resistance to virtually all antibiotics currently available in clinical practice"(4).
Some researchers in the concerns of antibiotics serious side effects in the treatment of diseases suggested that clinicians should eliminate the use of drugs associated with chronic or fatal because multiple therapeutic alternatives exist for virtually every potential infection(5).
Truly, herbal teas have been used popularly as natural alternatives for the treatment of infectious diseases. Dr. Mayram Hacioglu has found 31 herbal teas that may be alone and in combination with antibiotics or antifungals against some standard and clinical isolates antimicrobial activities(6).
Alfalfa is a flowering plant in the genus Medicago, belongings to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North American aboriginal have used Alfalfa seed as food, such as making bread and mush.
According to the Via Orabona 4, Università, chemical compound saponins found in alfalfa family exhibited antimicrobial activities in a selection of medically important yeasts, Gram-positive and negative bacteria.
Dr. Avato P, the lead author said, "(The antimicrobial) Activity (of alfalfa)was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus, and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae".
Furthermore, in the study of 40 steers fed either a sainfoin (hay or silage) or alfalfa (hay or silage) diet over a 9-week period, in vitro, alfalfa fed group showed a decline in fecal E. coli numbers marginally.
The study also suggested the result of the decline of anti-E. coli number is due to the presence of phytochemical phenolics in alfalfa.
In fact, The Karunya University in the investigation of Antimicrobial of Alfalfa(Medicago sativa) in various bacterial strain showed a positive effect of alfalfa seed extract in inhibition of five
bacterial strains namely Bacillus licheniformis, Pseudomonas aeruginosa, Lactococcus lactis, Klebsiella pneumonia. The efficacy also depends on the concentration of extract with the maximum inhibition was seen in 300µg/ml concentration of extract.
There is no doubt that intake of alfalfa regularly may be beneficiary in reduced risk and treatment of microbial infection and diseases. But further human trials are necessary.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antimicrobial activity of saponins from Medicago sp.: structure-activity relationship by Avato P1, Bucci R, Tava A, Vitali C, Rosato A, Bialy Z, Jurzysta M.(PubMed)
(2) Potential to reduce Escherichia coli shedding in cattle feces by using sainfoin (Onobrychis viciifolia) forage, tested in vitro and in vivo by Berard NC1, Holley RA, McAllister TA, Ominski KH, Wittenberg KM, Bouchard KS, Bouchard JJ, Krause DO.(PubMed)
(3) Antimicrobial screening of Alfalfa(Medicago sativa) in various bacterial strains by G.SHEELA JOY1 , and Dr.PHILOMENA GEORGE2 *. *Professor, 1B.Tech.student Department Biotechnology, Karunya University, Coimbatore, Tamil Nadu, India 641114(IJPDA)
(4) Mechanisms of Antibiotic Resistance by Jose M. Munita1,2,4 and Cesar A. Arias(PubMed)
(5) Antibiotic side effects by Cunha BA(PubMed)
(6) Antimicrobial activities of widely consumed herbal teas, alone or in combination with antibiotics: an in vitro study by Mayram Hacioglu, Sibel Dosler, Ayse Seher Birteksoz Tan, and Gulten Otuk(PMC)
The microorganism, first observed by Anton van Leeuwenhoek in 1675 is a class of microscopic organism, including a bacterium, virus, or fungus.
Believe or not, single-celled like bacteria, algae, and protozoa, or multicellular, such as algae and fungi can survive under all types of extreme environment.
And less than 1% of bacteria, can invade and cause infection and diseases.
Although the discovery of human antibiotics is medicines that kill or slow the growth of bacteria, however, over uses of the antibiotics have been found to induce microbial resistance to certain drugs.
Dr. Jose M. Munita, the lead author in the study of " Mechanisms of Antibiotic Resistance" said, "Emergence of resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide" and " The bacterial response to the antibiotic “attack” is the prime example of bacterial adaptation and the pinnacle of evolution. “Survival of the fittest” is a consequence of an immense genetic plasticity of bacterial pathogens that trigger specific responses that result in mutational adaptations, acquisition of genetic material or alteration of gene expression producing resistance to virtually all antibiotics currently available in clinical practice"(4).
Some researchers in the concerns of antibiotics serious side effects in the treatment of diseases suggested that clinicians should eliminate the use of drugs associated with chronic or fatal because multiple therapeutic alternatives exist for virtually every potential infection(5).
Truly, herbal teas have been used popularly as natural alternatives for the treatment of infectious diseases. Dr. Mayram Hacioglu has found 31 herbal teas that may be alone and in combination with antibiotics or antifungals against some standard and clinical isolates antimicrobial activities(6).
Alfalfa is a flowering plant in the genus Medicago, belongings to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North American aboriginal have used Alfalfa seed as food, such as making bread and mush.
According to the Via Orabona 4, Università, chemical compound saponins found in alfalfa family exhibited antimicrobial activities in a selection of medically important yeasts, Gram-positive and negative bacteria.
Dr. Avato P, the lead author said, "(The antimicrobial) Activity (of alfalfa)was especially high against Gram-positive bacteria (Bacillus cereus, B. subtilis, Staphylococcus aureus, and Enterococcus faecalis) with M. arabica being the species showing a broader spectrum of action. Discrete antifungal activity was also observed, mainly against Saccharomyces cerevisiae".
Furthermore, in the study of 40 steers fed either a sainfoin (hay or silage) or alfalfa (hay or silage) diet over a 9-week period, in vitro, alfalfa fed group showed a decline in fecal E. coli numbers marginally.
The study also suggested the result of the decline of anti-E. coli number is due to the presence of phytochemical phenolics in alfalfa.
In fact, The Karunya University in the investigation of Antimicrobial of Alfalfa(Medicago sativa) in various bacterial strain showed a positive effect of alfalfa seed extract in inhibition of five
bacterial strains namely Bacillus licheniformis, Pseudomonas aeruginosa, Lactococcus lactis, Klebsiella pneumonia. The efficacy also depends on the concentration of extract with the maximum inhibition was seen in 300µg/ml concentration of extract.
There is no doubt that intake of alfalfa regularly may be beneficiary in reduced risk and treatment of microbial infection and diseases. But further human trials are necessary.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antimicrobial activity of saponins from Medicago sp.: structure-activity relationship by Avato P1, Bucci R, Tava A, Vitali C, Rosato A, Bialy Z, Jurzysta M.(PubMed)
(2) Potential to reduce Escherichia coli shedding in cattle feces by using sainfoin (Onobrychis viciifolia) forage, tested in vitro and in vivo by Berard NC1, Holley RA, McAllister TA, Ominski KH, Wittenberg KM, Bouchard KS, Bouchard JJ, Krause DO.(PubMed)
(3) Antimicrobial screening of Alfalfa(Medicago sativa) in various bacterial strains by G.SHEELA JOY1 , and Dr.PHILOMENA GEORGE2 *. *Professor, 1B.Tech.student Department Biotechnology, Karunya University, Coimbatore, Tamil Nadu, India 641114(IJPDA)
(4) Mechanisms of Antibiotic Resistance by Jose M. Munita1,2,4 and Cesar A. Arias(PubMed)
(5) Antibiotic side effects by Cunha BA(PubMed)
(6) Antimicrobial activities of widely consumed herbal teas, alone or in combination with antibiotics: an in vitro study by Mayram Hacioglu, Sibel Dosler,
Ayse Seher Birteksoz Tan, and Gulten Otuk(PMC)Analyzing Antioxidant Impacts of Color Rices on Oxidative Stress Diseases, Suggested by PubMed Studies
Color rice may have potential effects in enhanced levels of antioxidants through its antioxidants and stimulation of the natural antioxidant enzymes found in the host tissue, some scientists suggested.
In compared to white rice with the hull, bran layer and cereal germ removed color rice contains a similar amount of calories and carbohydrates with only the hull removed.
Therefore, replacing the portion of white rice by color rice in your diet may eventually increase circulation of antioxidants in your body.
The results of the replacement not only reduce the risk of overexpression of levels of reactive oxygen species in the induction of free radical domino's effects but also protect the body against the imbalance of free radicals and antioxidants.
Antioxidants are molecules with a unique function in inhibited oxidation caused by other molecules.
Oxidative stress is a production as a result of an imbalance of ratio of antioxidant produced by the body tissue and free radical expression in the body.
In other words, low levels of natural antioxidants in the body may increase the risk of oxidative stress diseases.
Long-term overexpression of oxidative stress-induced damage of body tissues can lead to the development of many diseases. Link with a list of such diseases is provided below for your references.
Color rice or unpolished rice is a kind of whole, natural grain with varieties of color with only the outermost layer (hull) of the rice kernel removed.
Nutrients
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Fat
5. Protein
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (Vitamin B5)
10. Vitamin B6
11. Folate (Vitamin B9)
12.Calcium
13. Iron
14. Magnesium
15. Manganese
16. Phosphorus
17. Potassium
18. Sodium
19. Zinc
In the study of the extracts from white-, black-, and red-hulled rice prepared by sequential extraction with six different polar solvents to investigate the potential radical-scavenging activities, researchers at the National Agricultural Research Center for Kyushu Okinawa Region found that in compared to other extracts isolated, the acetone extract from red-hulled rice exhibits a high DPPH* and t-BuOO* scavenging activity
DPPH is a common free radical of the organic chemical compound 2,2-diphenyl-1-picrylhydrazyl used as a tool to monitor chemical reactions involving radicals.
t-BuOO (tert-Butyl hydroperoxide) is a free radical of organic peroxide widely used in a variety of testing of oxidation.
Further analysis showed that the efficacy of red hulled rice in inhibited the presence of free radicals was attributed to the phytochemical procyanidins, which are members of the class of flavonoids, formed from catechin and epicatechin molecules.
Some researchers suggested that procyanidins show more effects on the ability of free radical scavenging in the aqueous phase with the average molecular weight about 5000.
Additionally, in a range of about 500-18,000 procyanidins also facilitated a free radical reduction through the hydrogen atom transfer (HAT) and single electron transfer followed by proton transfer (SET-PT) mechanisms.
In phenolic compounds isolated from pigmented rice (black, red, and green rice) using aqueous mixtures of acetone, ethanol, and methanol to determine the most effective extraction solvent against the expression of reactive oxygen species, researchers showed that according to 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay,
* An extract from 40:60 acetone-water mixtures (v/v) provides the highest antioxidant activity in the ameliorated presence of levels of free radicals.
* Antioxidant activities of 40% acetone extracts of pigmented rice bran, measured in the range of 0 to 1500 μg/mL, process the highest total phenolic (259.5 μg/mg) and total flavonoid (187.4 μg/mg) contents in an exhibition of antioxidant activity of 83.6%.
In compared to other pigments, red rice bran showed the least efficacy in inhibited free radical butylated hydroxytoluene (144.5 μg/mL) also from the DPPH radical assay.
Dr. Jun H, after taking into account of other confounders, said, "The major phenolic acids of red rice bran were ferulic, vanillic and p-coumaric acids and " black and red rice bran could be better raw materials for manufacturing the food with high antioxidant activity".
These results of the investigation indicated that antioxidants contents in hulled rice are incomparable, depending on the color and the red and black hulled rice contain a highest antioxidants expression in compared to other colors.
Interestingly, when the hull is removed from three types of colored rice bran--forbidden rice, red rice, and green rice, the antioxidant levels were reduced by ONLY a fraction
* Forbidden rice, and green rice bran yield the antioxidant contents of 90%-100% and 80%-90%, respectively, and
* Red rice bran obtained from red rice yields the antioxidant content of 90%-100%.
The showings suggested that contrary to general belief, the pigmented skin of hull rice only represents a fraction of antioxidants in compared to all contents in the color rice bran.
Taking all together, non-hull colors rice may be considered as a functional food to promote antioxidant circulation in attenuated risk of oxidative stress in the induction of various forms of the disease.
People with a higher risk of oxidative stress may want to add a portion of non-hull color rice into their daily diet for preventive measure.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Polymeric procyanidins as radical-scavenging components in red-hulled rice.
Oki T1, Masuda M, Kobayashi M, Nishiba Y, Furuta S, Suda I, Sato T(PubMed)
(2)Antioxidant activities and phenolic compounds of pigmented rice bran extracts by Jun HI1, Song GS, Yang EI, Youn Y, Kim YS(PubMed)
(3) Antioxidant activity of colored rice bran obtained at different milling yields by Fujita A1, Fujitake H, Kawakami K, Nomura M(PubMed)(4) Effects of hydrothermal processes on antioxidants in brown, purple and red bran whole grain rice(Oryza sativa L.) by Min B1, McClung A2, Chen MH(PubMed)
(4) List of diseases caused by oxidative stress
(5) Computational study of the structure-free radical scavenging relationship of procyanidins by Mendoza-Wilson AM1, Castro-Arredondo SI2, Balandrán-Quintana RR(PubMed)
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