Arnica may have a substantial and positive effect in reduced risk and treatment of osteoarthritis, some scientists suggested.
Osteoarthritis (OA), a form of arthritis, is a chronic condition characterized by wear and tear on a joint due to aging, affecting over 25 million people in the United States in alone.
The University of Porto Medical School suggested that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).
Most common symptoms of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints.
The pain usually gets worse in a change of weather, at night and in the advanced diseases, the pain can occur even at rest.
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments.
An unhealthy diet that causes nutrient deficiency and overload, damage of cartilage, joint injury that did not heal properly, overuse, autoimmune rheumatoid arthritis also have potential effects in the increased prevalence of osteoarthritis.
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.
The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.
In a randomized, double-blind study of 204 patients to investigate the effect of ibuprofen (5%) and Arnica (50 g tincture/100 g, DER 1:20), as gel preparations in patients with radiologically confirmed and symptomatically active osteoarthritis of interphalangeal joints of hands, researchers found that after 21 days of treatment, group treated with Arnica exerted a significant effect in relieve and function of the joints of hands similar to group treated with the conventional medicine.
4.8% in the Arnica group reported some tolerate adverse effects in compared to 6.1% in the group treated with ibuprofen.
After taking into account of other co and con factors, Dr. the lead researcher said, "Our results confirm that this preparation of Arnica is not inferior to ibuprofen when treating osteoarthritis of hands".
In other to confirm the effect of Arnica as a form of functional food for treatment of osteoarthritis, scientists at the Valens Clinic for Rheumatism conducted a study of the topical application of Arnica montana fresh plant gel twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee.
According to the study, treatment after 3 and 6 weeks demonstrated a strong improvement of the median total scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), used by health professionals with proprietary set of standardized questionnaires to evaluate the condition of patients with osteoarthritis, including knee and hip, including pain, stiffness, and physical functioning of the joints.
Furthermore, in regard to the symptoms expression of osteoarthritis, application of the herbal preparation exerted a significant reduction of pain, stiffness, observed by the pain and stiffness score.
A score of the mean of function subscales also showed significant reductions at these time points.
The physical function subscale found in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is considered as more consistent with a stronger test-retest reliability in compared to the pain score with some inconsistencies across the studies.
However, local tolerate adverse effects were reported in 7.6 % of patients attended the study with one patient with an allergic reaction.
Interestingly, at the end of the study, 87% rated the tolerability of the gel as "good" or "fairly good," and 76% would use it again.
These results indicated that topical application of Arnica montana gel for 6 weeks alleviated symptoms of osteoarthritis in all aspects and may be considered as a well-tolerated, and effective treatment of mild to moderate OA of the knee.
Taken together, as a topical herbal medicine, Arnica may be considered a functional food for attenuated symptoms and treatment of osteoarthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study by Widrig R1, Suter A, Saller R, Melzer J.(PubMed)
(2) Arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial by Knuesel O1, Weber M, Suter A.(PubMed)
(3) The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review by Pereira D1, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E.(PubMed)
Thursday, December 6, 2018
Wednesday, December 5, 2018
Carrot Suppressed Oxidative Stress That Causes Atherosclerosis, Cancers, Diabetes, Rheumatoid Arthritis, Post-ischemic Perfusion Injury, Myocardial Infarction, Cardiovascular Diseases,... and Stroke
Carrots may have a profound and positive effect in reduced oxidative stress in the induction of related chronic diseases, including atherosclerosis, cancers, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases,... and stroke, some scientists suggested.
Oxidative stress is the indication of overexpression free radicals in the body due to depletion of antioxidants produced by the host tissue.
According to the Department of Biotechnology, M. J. College, "Overproduction of free radicals can cause oxidative damage to biomolecules, (lipids, proteins, DNA), eventually leading to many chronic diseases".
The studies of carrots in reduced overproduction of reactive oxygen species in facilitated oxidative stress were carried out by several respectable institutes and the results were published online medical literature.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.
In the investigation of the relation of dietary supplementation with lycopene (LYC), a major active biochemical compound found in carrot, on age-induced cognitive impairment, and the potential underlying mechanisms, using the behavioral tests, researchers at Northwest A&F University, researchers found that chronic injection of LYC exerts a potential effect in alleviated age-associated memory loss and cognitive defects through several mechanisms
Application of lycopene improved antioxidant produced by the host body in countering to the overexpression of free radicals, including glutathione, catalase, and superoxide dismutase activities and the levels of antioxidant-enzyme.
Treatment of the phytochemical displayed a strong activity in reversed age-associated neuronal damage and synaptic dysfunctions in the brain, through inhibited the levels of malondialdehyde (MDA) levels in associated to oxidative stress.
Malondialdehyde (MDA) levels are considered as oxidative maker used in the treatment of cancers and other oxidative related diseases.
Interestingly, researchers also indicated that chronic injection of bioactive lycopene lowers the levels of the accumulation of Aβ1-42 in the brains in aged CD-1 mice model.
Evidence findings suggested that Aβ-induced oxidative stress may place the majority of the causative effect of increased cellular oxidative stress upon oligomeric Aβ(1–42).
Furthermore, LYC supplementation also significantly reduced age-associated neuroinflammation caused by overexpression of free radicals in the activation of proinflammatory cytokines by inhibiting microgliosis (Iba-1) in response to damage to the central nervous system (CNS) and related inflammatory chemicals mediators.
These results overwhelmingly suggested that lycopene injection processes a strong effect in reduced risk and treatment of diseases associated with overproduction of ROS, through re-balancing the ratio of antioxidant and free radicals in the host body.
Moreover, in d-galactose-induced CD-1 male mice cognitive impairments, chronic LYC supplementation (50 mg/kg body weight per day) demonstrated a significant activity in inhibition of oxidative stress-induced cognitive defects.
Injection of lycopene also ameliorated histopathological damage and restored brain-derived neurotrophic factor (BDNF) levels in the hippocampus of mice. These findings reaffirms the conclusion of the Northwest A&F University study.
LYC treatment in an animal model also increased antioxidant of the host by activating the mRNA expressions of antioxidant enzymes HO-1 and NQO-1, and inhibited the oxidative stress in the induction of inflammatory cytokines IL-1β and TNF-α in host hippocampus.
More precisely, LYC attenuated neuronal oxidative damage through activation of Nrf2 signaling in increased levels of anti-inflammatory cytokines and inactivation of NF-κB translocation in signaling pro-inflammatory expression.
Dr. Zhao B, the lead scientist, after taking into account of co and confounders said, " LYC could ameliorate oxidative stress-induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-κB transcriptional pathway".
The findings indicated that carrot with major active compound lycopene may be considered as functional foods in prevention and treatment of oxidative related diseases by restoring the ratio of reactive oxygen species and levels of antioxidant in the body.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice by Zhao B1, Liu H1, Wang J1, Liu P1, Tan X1, Ren B1, Liu Z1, Liu X(PubMed)
(2) Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X2(PubMed)
Oxidative stress is the indication of overexpression free radicals in the body due to depletion of antioxidants produced by the host tissue.
According to the Department of Biotechnology, M. J. College, "Overproduction of free radicals can cause oxidative damage to biomolecules, (lipids, proteins, DNA), eventually leading to many chronic diseases".
The studies of carrots in reduced overproduction of reactive oxygen species in facilitated oxidative stress were carried out by several respectable institutes and the results were published online medical literature.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.
In the investigation of the relation of dietary supplementation with lycopene (LYC), a major active biochemical compound found in carrot, on age-induced cognitive impairment, and the potential underlying mechanisms, using the behavioral tests, researchers at Northwest A&F University, researchers found that chronic injection of LYC exerts a potential effect in alleviated age-associated memory loss and cognitive defects through several mechanisms
Application of lycopene improved antioxidant produced by the host body in countering to the overexpression of free radicals, including glutathione, catalase, and superoxide dismutase activities and the levels of antioxidant-enzyme.
Treatment of the phytochemical displayed a strong activity in reversed age-associated neuronal damage and synaptic dysfunctions in the brain, through inhibited the levels of malondialdehyde (MDA) levels in associated to oxidative stress.
Malondialdehyde (MDA) levels are considered as oxidative maker used in the treatment of cancers and other oxidative related diseases.
Interestingly, researchers also indicated that chronic injection of bioactive lycopene lowers the levels of the accumulation of Aβ1-42 in the brains in aged CD-1 mice model.
Evidence findings suggested that Aβ-induced oxidative stress may place the majority of the causative effect of increased cellular oxidative stress upon oligomeric Aβ(1–42).
Furthermore, LYC supplementation also significantly reduced age-associated neuroinflammation caused by overexpression of free radicals in the activation of proinflammatory cytokines by inhibiting microgliosis (Iba-1) in response to damage to the central nervous system (CNS) and related inflammatory chemicals mediators.
These results overwhelmingly suggested that lycopene injection processes a strong effect in reduced risk and treatment of diseases associated with overproduction of ROS, through re-balancing the ratio of antioxidant and free radicals in the host body.
Moreover, in d-galactose-induced CD-1 male mice cognitive impairments, chronic LYC supplementation (50 mg/kg body weight per day) demonstrated a significant activity in inhibition of oxidative stress-induced cognitive defects.
Injection of lycopene also ameliorated histopathological damage and restored brain-derived neurotrophic factor (BDNF) levels in the hippocampus of mice. These findings reaffirms the conclusion of the Northwest A&F University study.
LYC treatment in an animal model also increased antioxidant of the host by activating the mRNA expressions of antioxidant enzymes HO-1 and NQO-1, and inhibited the oxidative stress in the induction of inflammatory cytokines IL-1β and TNF-α in host hippocampus.
More precisely, LYC attenuated neuronal oxidative damage through activation of Nrf2 signaling in increased levels of anti-inflammatory cytokines and inactivation of NF-κB translocation in signaling pro-inflammatory expression.
Dr. Zhao B, the lead scientist, after taking into account of co and confounders said, " LYC could ameliorate oxidative stress-induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-κB transcriptional pathway".
The findings indicated that carrot with major active compound lycopene may be considered as functional foods in prevention and treatment of oxidative related diseases by restoring the ratio of reactive oxygen species and levels of antioxidant in the body.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice by Zhao B1, Liu H1, Wang J1, Liu P1, Tan X1, Ren B1, Liu Z1, Liu X(PubMed)
(2) Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X2(PubMed)
Tuesday, December 4, 2018
The Beverage Inhibits A Cluster Conditions That Cause Metabolic Syndrome, Scientists Reveal
A recent study conducted by some renowned institutes suggested that regular drinking of green tea may inhibit the early onset of metabolic syndrome.
Metabolic syndrome is a cluster condition associated to increase the risk of heart disease, stroke, and diabetes, including abnormal high blood pressure, high blood sugar and cholesterol together with excess body fat around the waist.
People with 3 of the above medical conditions are considered to have metabolic syndrome.
According to statistic, approximately, 25% of US adult population has metabolic syndrome.
Some researchers suggested that the syndrome is also associated to the condition of obesity as they share a similar component of insulin resistance.
Truly, the syndrome is not caused by a single condition but associated to a collection of risk factors,
including increases with age. race, obesity, diabetes and other diseases (cardiovascular disease, nonalcoholic fatty liver disease or polycystic ovary syndrome).
According to the joint study lead by the University of South Florida Morsani College of Medicine in investigated the prevalence of metabolic syndrome (MetS) and its components among U.S. adults, using the National Health and Nutrition Examination Survey 2007-2014 data suggested, ".... from 2007 to 2014, the prevalence of MetS remained stable in all sex, age, and race/ethnicity groups. Among the components of MetS, the prevalence of hypertriglyceridemia and fasting hyperglycemia decreased". and "The prevalence of elevated blood pressure and low high-density lipoprotein cholesterol level remained stable"(4).
Further analysis of the data, scientists found that the prevalence of abdominal obesity continues to increase in women, that can have a strong and lifelong impact in the induction of higher risk of metabolic syndrome.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
In a cross-sectional population-based survey including 8,821 adults (51.4% female) conducted in Krakow, Poland., both coffee and tea drinkers showed a negatively associated with MetS (OR 0.75, 95% CI 0.66, 0.86 and OR 0.79, 95% CI 0.67, 0.92, respectively).
The study also found that high tea consumers had lower BMI, waist circumference, but moderated decreased diastolic blood pressure, as well as negatively correlated central obesity and fasting plasma glucose in women, but not in men, in compared low drinker,
Furthermore, in the study including 8821 adults (51.4 % female), using food frequency questionnaires and matching food consumption data with the Phenol-Explorer database.conducted in Kraków, Poland, dietary polyphenol intake, a major compound found in green tea was associated inversely to the development of MetS (OR 0.80; 95 % CI 0.64, 0.98 and OR 0.70; 95 % CI 0.56, 0.86 for both men and women, respectively) in the highest quartile.
Dietary polyphenols in high quality also showed a negative association of WC, blood pressure, high lipoprotein cholesterol, and triglycerides in women, and fasting plasma glucose in both gender..
Dr. Grosso G, the lead author said, "(Depending to types of polyphenols) phenolic acids and stilbenes were significantly associated with MetS; lignans and stilbenes with WC; phenolic acids with blood pressure and triglycerides; and flavonoids with fasting plasma glucose" and " Among specific subclasses of polyphenols, hydroxycinnamic acids, flavanols, and dihydrochalcones had the most relevant role."
In support, the role of a polyphenol for treatment of Metabolic syndrome, a study of a total of 2725 participants free of hypertension at baseline tested for blood pressure or taking hypertensive medication within the last 2 weeks at 2-4-year follow-up visit was conducted by the Integrated Cancer Registry of Catania-Messina-Siracusa-Enna.
The final results showed that diet of highest quartile of total polyphenol intake was associated with 31% decreased the risk of hypertension compared with the lowest intake (OR 0.69, 95% CI 0.48, 0.98) in women with no significant association in men.
The study also stated that most influential phytochemicals in reduced risk and treatment of metabolic syndrome ingredients are phenolic acids, hydroxycynnamic acids as they showed a independently associated to lower odds of hypertension (OR 0.66, 95% CI 0.47, 0.93) in comparison to others.
Taking together, green tea with major chemical compounds of polyphenol may be used as functional foods in inhibited a cluster of conditions which associated to the onset of metabolic syndrome.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, s
Sources
(1) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3.(PubMed)
(2) Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Stefler D4, Bobak M4, Pająk A3.(PubMed)
(3) Dietary polyphenol intake and risk of hypertension in the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Kozela M3, Stefler D4, Bobak M4, Pajak A3.(PubMed)
(4) Trends in the prevalence of metabolic syndrome and its components in the United States 2007-2014 by Shin D1, Kongpakpaisarn K2, Bohra C(PubMed)
Monday, December 3, 2018
The Herbal Medicine and Plant Which Inhibits Inflammatory Diseases
Scientists may have found a herbal medicine that processes anti-inflammatory activity to protect our body from overexpression of pro-inflammatory cytokines in causing damage to healthy cells in the infectious site without reducing inflammatory cytokine activities.
Inflammation is a natural reaction of the immune system which initial protein signaling in stimulated production of inflammatory expression against foreign organisms invasion.
However, under the infectious condition, systematic inflammatory response in some cases may over overact, leading to overproduction of pro-inflammatory cytokines such as TNF alpha,.... and
Interleukins (IL) 1 and 6. which are a group of cytokines expressed by white blood cells of the immune system.
The Encyclopaedia Britannica wrote, "Like other cytokines, interleukins are not stored within cells but are instead secreted rapidly, and briefly, in response to a stimulus, such as an infectious agent. Once an interleukin has been produced, it travels to its target cell and binds to it via a receptor molecule on the cell’s surface" and "This interaction triggers a cascade of signals within the target cell that ultimately alter the cell’s behavior".
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.
The herb has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation stimulates sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.
In chronic related inflammation disease induced to 24 male Wister rats weighing 225 ± 25 gm, essential oil of catnip at the doses of 50 mg/kg, 100 mg/kg and 200 mg/kg researchers found that administered doses intraperitoneally exert significant effects in reduced paw edema by alleviating symptoms of both the acute and chronic forms of nociception, through its anti-inflammatory effect(1).
Dr. Ali T, the lead scientists at the Bangabandhu Sheikh Mujib Medical University, said, " NP 200 mg/kg reduced the pain sensation in the tail flick (p <0.01) and formalin test (p <0.001 in both phases). In paw edema test, NP 100 and 200 mg/kg significantly reduced the inflammation (p <0.01 and p <0.05)"(1).
The efficacy of catnip in inhibited chronic inflammation of experimental rats was attributed to chemical constituents 4aα,7α,7aβ-nepetalactone and 1,8-cineole that form major parts in phytochemicals of the herb.
The Tarbiat Modares University study also showed that Nepeta crispa essential oil enhances anti-inflammatory effects in the formalin-induced paw inflammation model and significantly reduced the paw edema(2).
More precisely, the essential oil injection ameliorated acute pain in animal models, including the tail-flick (p < 0.001) in the first phase of the formalin test (p < 0.01) through the production of analgesia(2).
In the late phase of the formalin test, the essential oil significantly reduced the pain-induced behavior against chronic pain(2).
Furthermore, in the study of extracts and isolated compounds tested against calcineurin, scientists showed that herbal catnip has a direct interaction with calcineurin through anti-inflammatory activity via modulation of T-cell in the mediation of inflammation(3).
Dr. Prescott TA and the research team at the Royal Botanic Gardens suggested, " Calcineurin inhibition should be considered as a potential mode of action when investigating the immunomodulatory activity of caffeoyl phenyle anoid glycoside containing plants"(3).
The findings suggested that herbal catnip may be considered as a functional food for treatment of acute and chronic inflammation without reducing the function of the immune system in protected our body against infection.
However, large sample size and multi-center clinical studies during the course of human consumption are necessary to reaffirm the catnip anti-inflammatory possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(2) Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(3) Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria by Prescott TA, Veitch NC, Simmonds MS.(PubMed)
(4) Interleukin PROTEIN by Encyclopaedia Britannica
Inflammation is a natural reaction of the immune system which initial protein signaling in stimulated production of inflammatory expression against foreign organisms invasion.
However, under the infectious condition, systematic inflammatory response in some cases may over overact, leading to overproduction of pro-inflammatory cytokines such as TNF alpha,.... and
Interleukins (IL) 1 and 6. which are a group of cytokines expressed by white blood cells of the immune system.
The Encyclopaedia Britannica wrote, "Like other cytokines, interleukins are not stored within cells but are instead secreted rapidly, and briefly, in response to a stimulus, such as an infectious agent. Once an interleukin has been produced, it travels to its target cell and binds to it via a receptor molecule on the cell’s surface" and "This interaction triggers a cascade of signals within the target cell that ultimately alter the cell’s behavior".
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.
The herb has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation stimulates sweating, promote menstruation, etc..
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.
In chronic related inflammation disease induced to 24 male Wister rats weighing 225 ± 25 gm, essential oil of catnip at the doses of 50 mg/kg, 100 mg/kg and 200 mg/kg researchers found that administered doses intraperitoneally exert significant effects in reduced paw edema by alleviating symptoms of both the acute and chronic forms of nociception, through its anti-inflammatory effect(1).
Dr. Ali T, the lead scientists at the Bangabandhu Sheikh Mujib Medical University, said, " NP 200 mg/kg reduced the pain sensation in the tail flick (p <0.01) and formalin test (p <0.001 in both phases). In paw edema test, NP 100 and 200 mg/kg significantly reduced the inflammation (p <0.01 and p <0.05)"(1).
The efficacy of catnip in inhibited chronic inflammation of experimental rats was attributed to chemical constituents 4aα,7α,7aβ-nepetalactone and 1,8-cineole that form major parts in phytochemicals of the herb.
The Tarbiat Modares University study also showed that Nepeta crispa essential oil enhances anti-inflammatory effects in the formalin-induced paw inflammation model and significantly reduced the paw edema(2).
More precisely, the essential oil injection ameliorated acute pain in animal models, including the tail-flick (p < 0.001) in the first phase of the formalin test (p < 0.01) through the production of analgesia(2).
In the late phase of the formalin test, the essential oil significantly reduced the pain-induced behavior against chronic pain(2).
Furthermore, in the study of extracts and isolated compounds tested against calcineurin, scientists showed that herbal catnip has a direct interaction with calcineurin through anti-inflammatory activity via modulation of T-cell in the mediation of inflammation(3).
Dr. Prescott TA and the research team at the Royal Botanic Gardens suggested, " Calcineurin inhibition should be considered as a potential mode of action when investigating the immunomodulatory activity of caffeoyl phenyle anoid glycoside containing plants"(3).
The findings suggested that herbal catnip may be considered as a functional food for treatment of acute and chronic inflammation without reducing the function of the immune system in protected our body against infection.
However, large sample size and multi-center clinical studies during the course of human consumption are necessary to reaffirm the catnip anti-inflammatory possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of the antinociceptive and anti-inflammatory effects of essential oil of Nepeta pogonosperma Jamzad et Assadi in rats by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(2) Antinociceptive and anti-inflammatory activities of the essential oil of Nepeta crispa Willd. in experimental rat models by Ali T, Javan M, Sonboli A, Semnanian S.(PubMed)
(3) Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria by Prescott TA, Veitch NC, Simmonds MS.(PubMed)
(4) Interleukin PROTEIN by Encyclopaedia Britannica
Sunday, December 2, 2018
Emodin, The Bioactive Ingredient That Treats Herpes Simplex Virus Infection
Herbal Cascara Sagrada containing major bioactive compound Emodin may be considered as a functional herb that inhibits diseases caused by infection of Herpes simplex virus, some scientists found.
Herpes simplex virus 1 and 2, the 2 members of the herpesvirus family, also are best known as human herpesvirus 1 and 2.
The classification of the virus is based on their likelihood to cause infection. According to WHO(5), in the expression of conventional medicine, there is no cure of the diseases and both HSV-1 and HSV-2 infections are lifelong.
* HSV-1 is mainly transmitted by oral-to-oral contact such as oral herpes.
* HSV-2 is a sexually transmitted infection.
However, both HSV-1 and HSV-2 can cause genital herpes.
According to statistic, approximately 3.7 billion people under age 50 (67%) are infected by HSV-1 and 417 million people aged 15-49 (11%) are infected by HSV-2 globally.
Some patients infected by the virus do not experience any symptoms, however, some may affect by symptoms of painful blisters or ulcers at the site of infection.
The virus is very contagious in the presence of symptoms but they can also be transmit to other from virus carriers who experience no symptoms at all.
Some researchers suggested that risk of HIV infection is strongly associated with patients who are infected by with HSV-2 with or without symptoms.
The study of risk factors of HSV-1 and 2
* (HSV-1) By the University of Bielefeld includes coitus experience, oral lesion, seropositivity and a higher level of perceived stress. And according to the returned questionnaire from participants, most lifestyle, gender or age are not risked factors with drinking alcohol was found to be a protective factor(3).
* (HSV-2) By the University of Washington, include seropositivity (include female gender), race (black), history of sexually transmitted infections, increasing numbers of sexual partners, sexual contact with commercial sex workers and low socio-economic status or level of education.
Particularly, age is considered as a related risk factor as it, likely reflects the cumulative number of sex partners, the age of initiation of sexual activity, and duration of sexual activity as well as chronic nature of HSV-2 infection"(4).
Conventional medicine used for the treatment of herpes simplex virus may be effective but inducing serious side effects of nausea, diarrhea, vomiting, digestive discomforts, headache, dizziness. fatigue,.... joint and muscle aches. In a serious case, the medicine may cause visual changes.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belongings to the family Rhamnaceae, native to western North America.
The herbal medicine bark has been used in traditional medicine for gastrointestinal support, thought its laxative and natural cleansing,
The chemical ingredients
Beside the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D,...... and hydroxy anthracene derivatives (HAD).
Emodin, the major component found in many herbs including cascara Sagrada, in the study against HSV infection exerted a significant effect in inhibited the replication of HSV-1 and HSV-2 in cell culture at the concentration of 50 μg/ml with an antiviral index of 2.07 and 3.53, respectively(1).
In an animal model, treatment of emodin increased the survival rate of HSV-infected mice, prolonged survival time(1).
After additional analysis of the experiment Dr. Xiong HR, the lead author suggested, injection of emodin expressed a higher efficacy in eliminated the virus from brain, heart, liver, and ganglion, in compared to the viral controls.
According to the differentiation of the China Medical University, application of emodin not only demonstrated a strong apoptotic activity in HSV cell cycle arrest but also reduced the plaque formation with an EC(50) of 21.5+/-4.4 muM(2).
Virus plaque formation according to plaque reduction assay is a measurement of plaque that the spread of progeny viruses released by individually infected cells is restricted to neighboring cells(7).
The Immunohistochemical staining using the anti-nucleocapsid protein antibody also demonstrated that emodin inhibited HSV infection through induced the accumulation of viral nucleocapsids (which refer to the protein coat (capsid) and the nucleic acid) in the nucleus in a dose-dependent manner(2).
Moreover, emodin also inhibited the yields of HSV-1 via the suppression of a novel target, UL12, an HSV-1 gene which plays an important role in processing viral DNA intermediates for survival by promoting production.
The findings suggested that herbal Cascara Sagrada process anti-herpes simplex virus potential through cell cycle arrest and disrupted viral DNA which promotes reduplication.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Cascara Sagrada anti-Herpes simplex virus possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo by Xiong HR, Luo J, Hou W, Xiao H, Yang ZQ.(PubMed)
(2) Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures by Hsiang CY, Ho TY.(PubMed)
(3) Herpes simplex virus type 2 transmission: risk factors and virus shedding by Wald A(PubMed)
(4) Risk factors of herpes simplex type 1 (HSV-1) infection and lifestyle factors associated with HSV-1 manifestations by Stock C1, Guillén-Grima F, de Mendoza JH, Marin-Fernandez B, Aguinaga-Ontoso I, Krämer A(PubMed)
(5) Herpes simplex virus, Key Fact by WHO
(6) Now playing: Viral plaque formation by Virology Blog
Herpes simplex virus 1 and 2, the 2 members of the herpesvirus family, also are best known as human herpesvirus 1 and 2.
The classification of the virus is based on their likelihood to cause infection. According to WHO(5), in the expression of conventional medicine, there is no cure of the diseases and both HSV-1 and HSV-2 infections are lifelong.
* HSV-1 is mainly transmitted by oral-to-oral contact such as oral herpes.
* HSV-2 is a sexually transmitted infection.
However, both HSV-1 and HSV-2 can cause genital herpes.
According to statistic, approximately 3.7 billion people under age 50 (67%) are infected by HSV-1 and 417 million people aged 15-49 (11%) are infected by HSV-2 globally.
Some patients infected by the virus do not experience any symptoms, however, some may affect by symptoms of painful blisters or ulcers at the site of infection.
The virus is very contagious in the presence of symptoms but they can also be transmit to other from virus carriers who experience no symptoms at all.
Some researchers suggested that risk of HIV infection is strongly associated with patients who are infected by with HSV-2 with or without symptoms.
The study of risk factors of HSV-1 and 2
* (HSV-1) By the University of Bielefeld includes coitus experience, oral lesion, seropositivity and a higher level of perceived stress. And according to the returned questionnaire from participants, most lifestyle, gender or age are not risked factors with drinking alcohol was found to be a protective factor(3).
* (HSV-2) By the University of Washington, include seropositivity (include female gender), race (black), history of sexually transmitted infections, increasing numbers of sexual partners, sexual contact with commercial sex workers and low socio-economic status or level of education.
Particularly, age is considered as a related risk factor as it, likely reflects the cumulative number of sex partners, the age of initiation of sexual activity, and duration of sexual activity as well as chronic nature of HSV-2 infection"(4).
Conventional medicine used for the treatment of herpes simplex virus may be effective but inducing serious side effects of nausea, diarrhea, vomiting, digestive discomforts, headache, dizziness. fatigue,.... joint and muscle aches. In a serious case, the medicine may cause visual changes.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belongings to the family Rhamnaceae, native to western North America.
The herbal medicine bark has been used in traditional medicine for gastrointestinal support, thought its laxative and natural cleansing,
The chemical ingredients
Beside the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D,...... and hydroxy anthracene derivatives (HAD).
Emodin, the major component found in many herbs including cascara Sagrada, in the study against HSV infection exerted a significant effect in inhibited the replication of HSV-1 and HSV-2 in cell culture at the concentration of 50 μg/ml with an antiviral index of 2.07 and 3.53, respectively(1).
In an animal model, treatment of emodin increased the survival rate of HSV-infected mice, prolonged survival time(1).
After additional analysis of the experiment Dr. Xiong HR, the lead author suggested, injection of emodin expressed a higher efficacy in eliminated the virus from brain, heart, liver, and ganglion, in compared to the viral controls.
According to the differentiation of the China Medical University, application of emodin not only demonstrated a strong apoptotic activity in HSV cell cycle arrest but also reduced the plaque formation with an EC(50) of 21.5+/-4.4 muM(2).
Virus plaque formation according to plaque reduction assay is a measurement of plaque that the spread of progeny viruses released by individually infected cells is restricted to neighboring cells(7).
The Immunohistochemical staining using the anti-nucleocapsid protein antibody also demonstrated that emodin inhibited HSV infection through induced the accumulation of viral nucleocapsids (which refer to the protein coat (capsid) and the nucleic acid) in the nucleus in a dose-dependent manner(2).
Moreover, emodin also inhibited the yields of HSV-1 via the suppression of a novel target, UL12, an HSV-1 gene which plays an important role in processing viral DNA intermediates for survival by promoting production.
The findings suggested that herbal Cascara Sagrada process anti-herpes simplex virus potential through cell cycle arrest and disrupted viral DNA which promotes reduplication.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Cascara Sagrada anti-Herpes simplex virus possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo by Xiong HR, Luo J, Hou W, Xiao H, Yang ZQ.(PubMed)
(2) Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures by Hsiang CY, Ho TY.(PubMed)
(3) Herpes simplex virus type 2 transmission: risk factors and virus shedding by Wald A(PubMed)
(4) Risk factors of herpes simplex type 1 (HSV-1) infection and lifestyle factors associated with HSV-1 manifestations by Stock C1, Guillén-Grima F, de Mendoza JH, Marin-Fernandez B, Aguinaga-Ontoso I, Krämer A(PubMed)
(5) Herpes simplex virus, Key Fact by WHO
(6) Now playing: Viral plaque formation by Virology Blog
Saturday, December 1, 2018
The Prominent Fruit That Arrests Prostate Cancer Cells Cycle Division
Scientists may have found a popular fruit that has a profound and positive effect in the prevention and treatment of prostate cancer, some studies suggested.
Prostate cancer is a medical and chronic disease characterized by cells growth disorderly and uncontrollably in the tissue of prostate gland. At the later stage, cancerous cells may travel a distance away from the prostate gland to infect other healthy tissue and organs.
According to a statistic in the US, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases out of 10 diagnosed with the condition are men aged 65 or older.
In 2017, 21,300 men in Canada were diagnosed with prostate cancer which represents 21% of all new cancer cases in men. And 4,100 men died from the disease(4).
Although Inherited mutations such as BRCA1 and BRCA2 that cause abnormal cell growth in the prostate gland are considered a major cause of prostate cancer, Acquired gene mutations such as overproduction of androgens (male hormones) gene that promotes prostate cell growth also contribute to prostate cancer risk in some men.
However, over years of studies also suggested that increases of age, ethnic group, family history, obesity, environment chemical,.... and unhealthy diet also have a strong implication in induction to the onset of prostate cancer.
Due to the slow progression of the disease, most patients do not experience any symptoms until the advanced stage. Most common symptoms including blood in the urine (hematuria), burning or pain during urination, difficulty urinating, decreased flow or velocity of urine stream, ......more frequent urges to urinate at night.
In some cases, patients may also be a loss of bladder control.
If you experience some of the above symptoms, please check with your doctor immediately to rule out the possibility.
Avocados are a commercially valuable fruit cultivated in tropical climates throughout the world.
The fruit has a green-skinned, pear-shaped fruit that ripens after harvesting, native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol; fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B(a).
According to the Case-control study of 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men attending the same urology clinics conducted by the University of the West Indie, intake of dietary MUFA from whole fruit of avocado are associated to reduced risk and treatment of prostate cancer(1).
Dr. Jackson MD, the lead scientist said, "Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes. High blood linolenic acid was directly related to prostate cancer" and " Dietary intakes of other fats were not associated with PCa"(1).
The University of California study showed that the anti-prostate cancer effects of avocado are not attributed to a single ingredient such as carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein but the interaction of all ingredients in the whole fruit in combination with other diet-derived phytochemicals(2).
The study suggested, intake of avocado stimulated the increase production of increase in p27 protein which involves function as tumor suppressor in controlling the cell cycle progression, in incubated PC-3 cells(2)
Avocado induced PC- 3 cancer cell death through cells apoptosis through G(2)/M cell cycle arrest the study continued(2).
In the evaluation of the effect of the anticancer of avocado conducted by the Purdue University study also showed a positive effect of the whole fruit in inhibition of six human tumor cell lines in culture, including human prostate adenocarcinoma (PC-3) cells(3).
The newly isolated Compounds 3 form of avocado containing g 1,2,4-triol moiety and a long aliphatic chain that terminates as either an alkane, alkene, or alkyne, respectively, exerted the strongest activity against PC-3 comparable to adriamycin, an anti-cancer conventional medicine(3).
Furthermore, when tested against yellow fever mosquito larva, the 3 form avocado also was more effective than rotenone, a natural botanical insecticide(3).
Therefore, men who are at high risk of prostate cancer may want to add a portion of avocado into their daily diet for preventive measure.
Taken altogether, avocado with abundant carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein may be considered a functional food for the prevention and treatment of prostate cancer.
However, additional large sample size and multicenter clinical trials with human consumption during the course of the disease are necessary to reconfirm avocado anti-prostate cancer possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Perseaamericana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
(4) Prostate cancer statistics, Canadian Cancer Society
12. Avocado and Skin health
13. Avocado and Cadiovascular diseases
Prostate cancer is a medical and chronic disease characterized by cells growth disorderly and uncontrollably in the tissue of prostate gland. At the later stage, cancerous cells may travel a distance away from the prostate gland to infect other healthy tissue and organs.
According to a statistic in the US, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases out of 10 diagnosed with the condition are men aged 65 or older.
In 2017, 21,300 men in Canada were diagnosed with prostate cancer which represents 21% of all new cancer cases in men. And 4,100 men died from the disease(4).
Although Inherited mutations such as BRCA1 and BRCA2 that cause abnormal cell growth in the prostate gland are considered a major cause of prostate cancer, Acquired gene mutations such as overproduction of androgens (male hormones) gene that promotes prostate cell growth also contribute to prostate cancer risk in some men.
However, over years of studies also suggested that increases of age, ethnic group, family history, obesity, environment chemical,.... and unhealthy diet also have a strong implication in induction to the onset of prostate cancer.
Due to the slow progression of the disease, most patients do not experience any symptoms until the advanced stage. Most common symptoms including blood in the urine (hematuria), burning or pain during urination, difficulty urinating, decreased flow or velocity of urine stream, ......more frequent urges to urinate at night.
In some cases, patients may also be a loss of bladder control.
If you experience some of the above symptoms, please check with your doctor immediately to rule out the possibility.
Avocados are a commercially valuable fruit cultivated in tropical climates throughout the world.
The fruit has a green-skinned, pear-shaped fruit that ripens after harvesting, native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Chemical constituents
The fruit contains campesterol, high amounts of β-sitosterol; fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B(a).
According to the Case-control study of 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men attending the same urology clinics conducted by the University of the West Indie, intake of dietary MUFA from whole fruit of avocado are associated to reduced risk and treatment of prostate cancer(1).
Dr. Jackson MD, the lead scientist said, "Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes. High blood linolenic acid was directly related to prostate cancer" and " Dietary intakes of other fats were not associated with PCa"(1).
The University of California study showed that the anti-prostate cancer effects of avocado are not attributed to a single ingredient such as carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein but the interaction of all ingredients in the whole fruit in combination with other diet-derived phytochemicals(2).
The study suggested, intake of avocado stimulated the increase production of increase in p27 protein which involves function as tumor suppressor in controlling the cell cycle progression, in incubated PC-3 cells(2)
Avocado induced PC- 3 cancer cell death through cells apoptosis through G(2)/M cell cycle arrest the study continued(2).
In the evaluation of the effect of the anticancer of avocado conducted by the Purdue University study also showed a positive effect of the whole fruit in inhibition of six human tumor cell lines in culture, including human prostate adenocarcinoma (PC-3) cells(3).
The newly isolated Compounds 3 form of avocado containing g 1,2,4-triol moiety and a long aliphatic chain that terminates as either an alkane, alkene, or alkyne, respectively, exerted the strongest activity against PC-3 comparable to adriamycin, an anti-cancer conventional medicine(3).
Furthermore, when tested against yellow fever mosquito larva, the 3 form avocado also was more effective than rotenone, a natural botanical insecticide(3).
Therefore, men who are at high risk of prostate cancer may want to add a portion of avocado into their daily diet for preventive measure.
Taken altogether, avocado with abundant carotenoids (zeaxanthin, alpha-carotene, and beta-carotene), lutein may be considered a functional food for the prevention and treatment of prostate cancer.
However, additional large sample size and multicenter clinical trials with human consumption during the course of the disease are necessary to reconfirm avocado anti-prostate cancer possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) Leung's Encyclopedia of Natural Ingredients:Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL.(PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Perseaamericana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
(4) Prostate cancer statistics, Canadian Cancer Society
12. Avocado and Skin health
13. Avocado and Cadiovascular diseases
Friday, November 30, 2018
Caffeinated Coffee, The Liver Protective and Anti Non Alcoholic Liver Disease Beverage
Habitual caffeinated coffee intake may have a potential of curing Non-Alcoholic Liver Disease, some scientists found.
Non-alcohol fatty liver disease (NAFLD) is a chronic medical condition of the fatty liver caused by excessive fat deposited (steatosis) in the liver other than over-consumption of alcohol.
The disease is a common liver disorder found in most developed countries, probably due to over-consumption of carbohydrates which are considered as a major stimulus for hepatic de novo lipogenesis (DNL), the esterification of plasma free fatty acids, such as American diet.
According to a clinical assessment conducted by the joint study led by the Global Clinical Research, " Hepatic de novo lipogenesis(DNL), the synthesis of new fatty acids from non-lipid sources, is thought to play a pivotal role in the development of NAFLD"(4).
In compared to lipids that were defined as soluble substances in organic solvents, including the various types of fatty acids, eicosanoids, fatty alcohols, fatty aldehydes, ...... and hydrocarbons, fatty acids from non-lipid sources are men make substances that do not rely on organic solvents, but use other chemicals to separate the lipids from the rest of the food, including buttermilk fat, beef fat (tallow, suet), chicken fa,t cream pork fat, (lard),... and stick margarine
Dr. Paglialunga S. the lead author suggested as of today, there is no NAFLD-specific therapeutic agent available. However, pharmaceutical drugs aimed at reducing hepatic fat accretion may prove to be a powerful ally in the treatment and management of this disease(4).
Some researchers also said a chronic metabolic derangement referred to steatosis are directly associated with patients with obesity and type 2 diabetes(4).
According to the statistic, approximately, 80 millions of US adults suffer from Non-alcoholic fatty liver disease (NAFLD) in which 30% to 40% of those patients show no visible signs and symptoms.
However, most patients with Non-Alcoholic Liver Disease may experience signs and symptoms of abdominal swelling, enlarged blood vessels just beneath the skin's surface, spleen, red palms,.... and jaundice as a result of liver advanced scarring (steatohepatitis and cirrhosis).
If you have some of the above symptoms, please see your doctor right the way to rule out the possibility.
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to a retrospective cross-sectional study on patients with non-alcoholic fatty liver disease (NAFLD), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection to determine the effects of coffee intake on a non-invasive marker of liver fibrosis, coffee intake of 2 or more cups per day demonstrated a significant reduced liver symptom of stiffness, after adjustment for age, gender, smoking, alcohol consumption, in compared to other subgroups.
Additionally, in the review of epidemiological and clinical evidence by the Zhejiang University, researchers suggested coffee intake may have a profoundly reduced severity and risk of non-alcoholic fatty liver disease (NAFLD) prevalence.
In fact, the effect of coffee on attenuated risk of non-alcoholic fatty liver disease (NAFLD) incidence may be also involved other chemical constituents other than caffeine.
Dr. Chen S, the lead researchers suggested that said, "Several possible mechanisms underlying coffee's hepatoprotective effects in NAFLD include antioxidative, anti-inflammatory, and antifibrotic effects".
Interestingly, the review of literature published in the database of Medline and Embase up to March 2015, showed that coffee and coffee caffeine intake have a strong impact in protecting the liver against complications of fibrosis incidence.
Information collected indicated that coffee and coffee caffeine intake have an enormous demonstration in ameliorated risk and symptoms of Nonalcoholic liver disease, but some researchers suggested that other components may also play an important role in the enhancement of these results.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee Intake Is Associated with a Lower Liver Stiffness in Patients with Non-Alcoholic Fatty Liver Disease, Hepatitis C, and Hepatitis B by Hodge A1,2, Lim S3, Goh E4, Wong O5, Marsh P6, Knight V7, Sievert W8,9, de Courten B10.(PubMed)
(2) Coffee and non-alcoholic fatty liver disease: brewing evidence for hepatoprotection? by Chen S1, Teoh NC, Chitturi S, Farrell GC.(PubMed)
(3) Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies by Marventano S1, Salomone F2, Godos J3, Pluchinotta F4, Del Rio D5, Mistretta A1, Grosso G6.(PubMed)
(4) Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease by Sabina Paglialunga
1 and Clayton A. Dehn(PubMed)
Non-alcohol fatty liver disease (NAFLD) is a chronic medical condition of the fatty liver caused by excessive fat deposited (steatosis) in the liver other than over-consumption of alcohol.
The disease is a common liver disorder found in most developed countries, probably due to over-consumption of carbohydrates which are considered as a major stimulus for hepatic de novo lipogenesis (DNL), the esterification of plasma free fatty acids, such as American diet.
According to a clinical assessment conducted by the joint study led by the Global Clinical Research, " Hepatic de novo lipogenesis(DNL), the synthesis of new fatty acids from non-lipid sources, is thought to play a pivotal role in the development of NAFLD"(4).
In compared to lipids that were defined as soluble substances in organic solvents, including the various types of fatty acids, eicosanoids, fatty alcohols, fatty aldehydes, ...... and hydrocarbons, fatty acids from non-lipid sources are men make substances that do not rely on organic solvents, but use other chemicals to separate the lipids from the rest of the food, including buttermilk fat, beef fat (tallow, suet), chicken fa,t cream pork fat, (lard),... and stick margarine
Dr. Paglialunga S. the lead author suggested as of today, there is no NAFLD-specific therapeutic agent available. However, pharmaceutical drugs aimed at reducing hepatic fat accretion may prove to be a powerful ally in the treatment and management of this disease(4).
Some researchers also said a chronic metabolic derangement referred to steatosis are directly associated with patients with obesity and type 2 diabetes(4).
According to the statistic, approximately, 80 millions of US adults suffer from Non-alcoholic fatty liver disease (NAFLD) in which 30% to 40% of those patients show no visible signs and symptoms.
However, most patients with Non-Alcoholic Liver Disease may experience signs and symptoms of abdominal swelling, enlarged blood vessels just beneath the skin's surface, spleen, red palms,.... and jaundice as a result of liver advanced scarring (steatohepatitis and cirrhosis).
If you have some of the above symptoms, please see your doctor right the way to rule out the possibility.
Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
According to a retrospective cross-sectional study on patients with non-alcoholic fatty liver disease (NAFLD), hepatitis C virus (HCV), and hepatitis B virus (HBV) infection to determine the effects of coffee intake on a non-invasive marker of liver fibrosis, coffee intake of 2 or more cups per day demonstrated a significant reduced liver symptom of stiffness, after adjustment for age, gender, smoking, alcohol consumption, in compared to other subgroups.
Additionally, in the review of epidemiological and clinical evidence by the Zhejiang University, researchers suggested coffee intake may have a profoundly reduced severity and risk of non-alcoholic fatty liver disease (NAFLD) prevalence.
In fact, the effect of coffee on attenuated risk of non-alcoholic fatty liver disease (NAFLD) incidence may be also involved other chemical constituents other than caffeine.
Dr. Chen S, the lead researchers suggested that said, "Several possible mechanisms underlying coffee's hepatoprotective effects in NAFLD include antioxidative, anti-inflammatory, and antifibrotic effects".
Interestingly, the review of literature published in the database of Medline and Embase up to March 2015, showed that coffee and coffee caffeine intake have a strong impact in protecting the liver against complications of fibrosis incidence.
Information collected indicated that coffee and coffee caffeine intake have an enormous demonstration in ameliorated risk and symptoms of Nonalcoholic liver disease, but some researchers suggested that other components may also play an important role in the enhancement of these results.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee Intake Is Associated with a Lower Liver Stiffness in Patients with Non-Alcoholic Fatty Liver Disease, Hepatitis C, and Hepatitis B by Hodge A1,2, Lim S3, Goh E4, Wong O5, Marsh P6, Knight V7, Sievert W8,9, de Courten B10.(PubMed)
(2) Coffee and non-alcoholic fatty liver disease: brewing evidence for hepatoprotection? by Chen S1, Teoh NC, Chitturi S, Farrell GC.(PubMed)
(3) Coffee and tea consumption in relation with non-alcoholic fatty liver and metabolic syndrome: A systematic review and meta-analysis of observational studies by Marventano S1, Salomone F2, Godos J3, Pluchinotta F4, Del Rio D5, Mistretta A1, Grosso G6.(PubMed)
(4) Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease by Sabina Paglialunga
1 and Clayton A. Dehn(PubMed)
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