The Foods' Bioactive Chemicals That Process Anti Endometriosis Activity

Endometriosis is a painful disorder characterized by endometrial cells that grow in another area in the reproductive organs, such as ovaries, fallopian tubes,..... and the tissue lining your pelvis, outside of the uterus.

The causes of endometriosis are debatable. Some researchers suggested that normally a layer of endometrial lining in the inside of the uterus is expelled through menstruation, during the last stage of menstrual cycle, instead, some of the endometrial tissues grow somewhere else in the body, causing endometriosis.

There are numbers of the theory proposed that endometrial tissues grow somewhere else in the body are results of

* Uterine structure abnormalities
The theory suggested women with uterine structure abnormalities are associated to increase the risk of dysfunctional uterine peristalsis. As the condition progress, dysperistalsis of uterus constructions might underlie disorders of endometriosis(6).

* Retrograde menstruation
Sampson’s theory of retrograde menstruation is the oldest principle explaining the etiology of endometriosis. The theory suggested. that endometriosis is the result of the retrograde flow of endometrial cells that are transported through the fallopian tubes into the peritoneal cavity during menstruation.

* Genetic alternation
There are numbers of gene that cause uterine structural abnormalities and abnormal endometrial development, including HOX gene.

However, the joint study of "Genetics and Genomics of Endometriosis" lead by the Sanford School of Medicine of the University of South Dakota, " the etiology of endometriosis remains enigmatic but it does appear to cluster in families. Genetic studies have demonstrated an increased frequency of the disease in close relatives with the type of inheritance most likely polygenic/multifactorial. Genomic studies continue to explore differences in gene expression and understanding the basic biology of the disease"(9).

Endometriosis also reacts to hormone signals of the monthly menstrual cycle by building up tissues, breaking them and eliminating them through the menstrual period.

Types of food to prevent and treat endometriosis
1. Flaxseed and fish oil (EPA/DHA)
In the study of the effect of oral administration of pure EPA on endometriosis surgically induced in the experimental rabbits in compared to control, researchers found that pure EPA treatment group s exerts significant decrease of peritoneal fluid PGE2 and IL-1-beta concentrations in compared to control that shows increased significantly after induction of endometriosis(1).

Prostaglandin E(2), PGF2-alpha and proinflammatory IL-1-beta concentrations are up-regulated in patients with endometriosis in compared to healthy women.

Furthermore, in endometriosis surgically induced animal study, researchers indicated that at day 10, injection of EPA/DHA in endometrial infected group shows a decrease of concentrations of both peritoneal fluid PGE2 and PGF2-alpha(2).

Moreover, total endometrial implant diameter 8 weeks after induction of endometriosis was significantly smaller in the experimental group compared to the controls(2).

Dr. Covens AL, the lead scientist at the final report of the experiment said, "dietary supplementation with fish oil, containing the n-3 polyunsaturated fatty acids EPA and DHA, can decrease intraperitoneal PGE2 and PGF2-alpha production and retard endometriotic implant growth in this animal model of endometriosis"(2).


2. Organic Soy(Isoflavone)
In the study to examine the associations among soy isoflavone intake, estrogen receptor 2 (ESR2) gene polymorphisms and risk of endometriosis, researchers showed that higher levels of urinary genistein and daidzein were associated with decreased risk of advanced endometriosis but not early endometriosis(3).

In advanced endometriosis, the adjusted odds ratio for the highest quartile group was 0.21 for genistein and 0.29 for daidzein in compared with the lowest group(30.

Inverse associations were also noted between urinary isoflavones and the severity of endometriosis. For advanced endometriosis(3).

However, the study is based on a total of 138 Japanese women age 20-45 years old who had consulted a university hospital for infertility in Tokyo, Japan in 1999 or 2000. due to endometriosis.

Therefore, a large example size and multi-centers study different ethnic groups involved are necessary to reconfirm the isoflavone anti endometriosis possibility.



3. Green tea (epigallocatechin-3-gallate (EGCG))
In the study to evaluate the antiangiogenesis mechanism of epigallocatechin-3-gallate (EGCG) in an endometriosis model in vivo, researchers at The Chinese University of Hong Kong, showed that EGCG inhibits microvessels in endometriotic implants.

EGCG selectively also suppressed vascular endothelial
* Growth factor C (VEGFC), the expression is increased eutopic and ectopic endometrium of endometriosis patients(10)

* Tyrosine kinase receptor which is targeted by a number of pharmaceutical compounds for the treatment of endometriosis successfully in vitro and animal models(11).

* VEGF receptor 2 (VEGFR2) or Flk-1 expression which is significantly higher in endometriotic lesions and confirmed the angiogenic potential of these lesions(12)..


4. Skin and seed of grape (Resveratrol)
In the study to investigate the effects of resveratrol on human endometriotic implants in a nude mouse model and to examine its impact on human endometrial stromal (HES) cell invasiveness in vitro, scientists found that(5)

* Resveratrol treatment group demonstrated a decreased number of endometrial implants by 60% and the total volume of lesions per mouse by 80%.

* Resveratrol injection at a concentration of 10-30 μM also induced a reduction of invasiveness of HES by up to 78%.

These results suggested that resveratrol may be considered as a functional supplement for reduced risk of endometriosis in the nude mouse and invasiveness of HES cells(5).

5. Olive oil (Melatonin)
The study of Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway by Dr. Paul S, and scientist at the Indian Institute of Chemical Biology, showed that during the early phase of endometriosis, MMP-3, a protein was found to promote endometriosis(13) is increased and associated with the expression of transcription factor, c-Fos gene which may play a role in the molecular mechanisms of estrogen action on the induction, promotion or progression of endometriosis(14).

These increased levels of MMP-3 activity that parallel to c-Fos gene expression in endometriosis were inhibited by melatonin, a major bioactive ingredient found in olive oil pre-treatment, researchers after taking into account other co and confounders.

Melatonin-treated group also demonstrated a significant effect on regression of glandular epithelium when compared to untreated mice through apoptotic pathway involving increased cells death in endometrial zones(6).




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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/1607749
(2) http://www.ncbi.nlm.nih.gov/pubmed/2832216
(3) http://www.ncbi.nlm.nih.gov/pubmed/17474167
(4) http://www.ncbi.nlm.nih.gov/pubmed/21821246
(5) http://www.ncbi.nlm.nih.gov/pubmed/20844278
(6) http://www.ncbi.nlm.nih.gov/pubmed/20609072
(7) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209923/
(8) https://www.hindawi.com/journals/ijrmed/2014/179515/
(9) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346178/
(10) https://www.ncbi.nlm.nih.gov/pubmed/23334337
(11) https://watermark.silverchair.com/dmv060.pdf
(12) https://www.ncbi.nlm.nih.gov/pubmed/20085636
(13) https://www.ncbi.nlm.nih.gov/pubmed/15879464
(14) https://www.ncbi.nlm.nih.gov/pubmed/19199093

Chamomile Extracts That Modulate the Function of Immune System

Chamomile (Matricaria chamomilla), in a recent study conducted by some renowned institutions, restored the resistance against lethal infection with the predominately granulocyte-dependant Candida albicans in immunosuppressed mice.

The immune system is the set of cells comprised of the body's defense system against diseases.

In normal immunity, active immunity may also be artificially acquired active immunity caused by injection of the vaccine, a substance that contains antigen and passive immunity is an auto response of immune system against infection through production of antigen.

Immunity can also be passive and active, Dr. David Baxter, in the article of "Active and passive immunity, vaccine types, excipients and licensing" wrote, "Active immunity refers to the process of exposing the body to an antigen to generate an adaptive immune response: the response takes days/weeks to develop but may be long lasting—even lifelong" and " Passive immunity refers to the process of providing IgG antibodies to protect against infection; it gives immediate, but short-lived protection—several weeks to 3 or 4 months at most. Passive immunity is usually classified as natural or acquired"(3).

However, an abnormal immune response such as overactive and under active may cause a weakened immune system or autoimmune diseases.

The common characteristic of over active immunity is the immune system that attacks healthy tissues, thus provoking inflammation, as well as tissue and organ damage. Truly, there are There are an estimated 80 autoimmune diaereses, that affect 14–22 million Americans, or 5%–8% of the population, and their prevalence is on the rise, according to the US National Institutes of Health (NIH)(4).

Underactive immunity can be a primary immune deficiency or acquired immune deficiency. People with weakened immunity, regardless of the cause are at constant danger of infections from bacteria, viruses, and fungi.



Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae,

The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.

In the study to examine the immunomodulatory effect of a group of medicinal plant including Silene (Silene nocturna), Black seed (Nigella sativa) and Chamomile (Matricaria chamomilla) growing in Egypt in Balb/c mice, researchers found that intraperitoneal injection chamomile methanolic extract was found to enhance immunity through the increased total white blood cells count(1).


In compared to other plants extracts, chamomile extracts also increased bone marrow cellularity significantly(1).

Furthermore, spleen weight of chamomile treated groups was significantly increased. increased weight of spleen is an indication of improved immune activity as spleen plays an important role in the modulation of the immune system and in the maintenance of peripheral tolerance via the clearance of circulating apoptotic cells, the differentiation and activation of T and B cells and production of antibodies(5)



In groups induced immunosuppressed with cyclophosphamide, group pretreated with the chamomile extracts inhibit Candida significantly through restored their resistance against lethal infection with the predominately granulocyte-dependant Candida albicans(1).



Dr. Ghonime M, the lead author said, These results confirm the immunomodulatory activity of Silene, Black seed, and Chamomile extracts and may have therapeutical implications in the prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".



According to the Russian State Medical University, Moscow, heteropolysaccharides, a class of sugars, found in Matricaria chamomilla L. showed to normalize the developing of the immune response upon air cooling.

These results are attributed to chamomile heteropolysaccharides effects in initiated immunostimulating properties of heavy erythrocytes (macrocytes), the group of enlargement of red blood cells, activated of immunoregulation of cells of peripheral blood, and increased the sensitivity of effector cells to helper signals.

Dr. Ghonime M, the lead author, said, "immunomodulatory activity,.....Chamomile extracts may have therapeutical implications in the prophylactic treatment of opportunistic infections and as supportive treatment in oncogenic cases".

There is no doubt that chamomile and its chemical ingredients have expressed a strong immunomodulatory activity in protection of our body against various diseases, but intake of large quantity should be taken with care to avoid toxicity.

However, further data collection on large example size and multi-centers studies performed with human consumption of the chamomile extracts during the course of the disease will be necessary to complete the picture of chamomile immunomodulatory possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of immunomodulatory effect of three herbal plants growing in Egypt by Ghonime M1, Eldomany R, Abdelaziz A, Soliman H.(PubMed)
(2) [The immunomodulating activity of the heteropolysaccharides from German chamomile(Matricaria chamomilla) during air and immersion cooling].[Article in Russian] by Uteshev BS1, Laskova IL, Afanas'ev VA.(PubMed)
(3) Active and passive immunity, vaccine types, excipients and licensing by David Baxter(Oxford Academic)
(4) When the immune system goes on the attack by Vicki Brower(PMC)
(5) Liver-spleen axis: Intersection between immunity, infections and metabolism by Giovanni Tarantino, Antonella Scalera, and Carmine Finelli(PMC)

Fennel Seed Extracts That Gobble Up Toxins Caused by Medication Toxicity, Scientists Show

Fennel seeds may have a potential to act as liver antitoxins enzymes in removed xenobiotics from our body, some scientists suggested.

Liver cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme, mainly found in the liver with function in stimulating the removal of toxins from our body through the oxidation of small foreign organic molecules (xenobiotics).

Acute drug toxicity is a condition characterized by having too much of a drug in the body at once caused by overdoses of a certain medicine.

Otherwise, drugs toxicity is a condition of toxin accumulation caused by long-term intake of medicine which has a strong and negative impact on the liver or kidneys enzymes that are responsible for toxin removals.

The signs and symptoms of toxicity differ depending on the medication. However, most common symptoms may include diarrhea, dizziness, nausea, stomach pains, vomiting, and weakness.

Untreated drug toxicity may induce complications of ataxia, muscle twitches, slurred speech, nystagmus, seizures, coma,....... and, in rare cases, heart problems and death.

Dr. ALASDAIR BRECKENRIDGE, in the article " A clinical pharmacologist's view of drug toxicity" wrote, "Our ability to understand the basis of adverse drug reactions has improved progressively, and with it, the ability to prevent their occurrence; one aim of the clinical pharmacologist is to identify patients at special risk" and " With a fair degree of certainty one can also predict that advances in bioinformatics, genomics, and combinatorial chemistry will progressively contribute to clinical toxicology in the future"(6).

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean


The herb or food has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the study to compare the effectiveness of herbal compounds isolated from fennel against toxins that mediated by human liver cytochrome P450 3A4, researchers found that 13 compounds process a strong inhibitory activity(1).
Among these compounds, 5-methoxypsoralen (5-MoP) showed the strongest inhibition of toxins induced by drug interaction with an IC50 value of 18.3 μm and with a mixed type of inhibition(1).

According to the Brescia University Hospital, 5-methoxypsoralen (5-MOP) may be considered an alternative to 8-methoxypsoralen (8-MOP) for photochemotherapy of psoriasis, proven by the study in compared the clinical efficacy and tolerability of 5-MOP (1.2 mg/kg)-UVA versus 8-MOP (0.6 mg/kg)-UVA therapy in 25 patients of skin type III and IV(5).


The University of Toyama conducted an experiment to examine whether methanolic extract of fennel showed a characteristic of mechanism-based inactivation on erythromycin N-demethylation mediated by human liver microsomal cytochrome P450 3A4 (CYP3A4), suggested, 5-methoxypsoralen (5-MOP) showed the strongest inhibition with an IC50 value of 18.3 microM and a mixed type of inhibition, similar to those of above study.

With the preincubation time of 20 min only, 5-MOP showed preincubation time dependency with the IC50 value decreased from 18.3 microM with a preincubation time of 0 min to 4.6 microM with a preincubation time of 20 min(2).



These results suggested that 5-MOP acts as a human Liver Cytochrome P450 3A4 in inhibition of toxins caused by drugs interaction in a time-dependent manner.

Additionally, in the examine the antitoxic effect of 30 sample plants of Indonesia, caused by injection of xenobiotics, researchers showed that methanol extracts isolated from fennel seed exerted time-dependent inhibition toxins oxidized similarly to those of cytochrome P450 3A4 (CYP3A4) and CYP2D6.


In comparing the experimental injection to another plant with the same volume, fennel seeds extract should contain mechanism-based inhibitors on CYP3A4.

Mechanism-based inhibition or suicide inhibition, also known as suicide inactivation is an irreversible form of enzyme inhibition. If you need more information about the definition, please click the link provided by the Evidence Based Medicine

Taken together, fennel may be considered a functional food in protect liver detoxed enzymes against overexpression of toxins caused by small foreign organic molecules.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Inhibition on human liver cytochrome P450 3A4 by constituents of fennel (Foeniculum vulgare): identification and characterization of a mechanism-based inactivator by Subehan1, Zaidi SF, Kadota S, Tezuka Y(PubMed)
(3) Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants by Subehan1, Usia T, Iwata H, Kadota S, Tezuka Y.(PubMed)
(4) Antimicrobial and P450 Inhibitory Properties of Common Functional Foods by San Nguyen1 , Huang Huang2 , Brian C. Foster1,3, Teresa W. Tam1 , Tim Xing2 , Myron L. Smith2 , John T. Arnason1 , Humayoun Akhtar(J Pharm Pharm Sci (www.cspsCanada.org) 17(2) 254 - 265, 2014)
(5) A reappraisal of the use of 5-methoxypsoralen in the therapy of psoriasis by Calzavara-Pinton P1, Ortel B, Carlino A, Honigsmann H, De Panfilis G(PubMed)
(6) A clinical pharmacologist's view of drug toxicity by ALASDAIR BRECKENRIDGE(PMC)

Black (Dried, Common) Bean, The Legume That Promotes Weight Loss

Black or common bean with abundant fiber may be considered a functional food in inducing weight loss of obese and overweight subjects, some scientists suggested.

Weight loss is a decrease of body weight regardless to circumstances. However, healthy weight loss is a gradual weight reduction through exercise, change of diet and lifestyle without affecting the nutrients intake.



Losing weight is not easy, and it takes commitment. Even 5% or 10% of weight loss may have a significant effect in improved your health. A step-by-step guide is also necessary to get you on the right track.


The CDC said,, " if you weigh 200 pounds, a 5 percent weight loss equals 10 pounds, bringing your weight down to 190 pounds. While this weight may still be in the “overweight” or “obese” range, this modest weight loss can decrease your risk factors for chronic diseases related to obesity"(5).

Some researchers suggested over weight and obesity are associated to increase the risk of short and long term health problems.

According to the National Institutes of Diabetes and Digestive and Kidney Diseases, overweight and obesity are associated to compilations of type 2 diabetes, high blood pressure, heart disease, and strokes,..... and certain types of cancer.


The BMI can be a helpful tool to determine whether you are underweight, normal weight, overweight, or obesity.

* Under weight if MBI is less than 18.5
* Normal weight if BMI is in the range from 18.5 to 24.9
* Overweight: if BMI is in the range from 25 to 29.9
* Obesity if BMI is 30 or higher


According to statistic, approximately, over 68% of Amerrican are either over weight or obesity.
and Americans spent over $60 billion a year to purchase diet programs and products.


Black bean, a small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can bought in most grocery stores all around the year in dried and canned forms.

It is believed that black bean was first domesticated growth in South America.

In the review of the literature data base, researchers at the University of Exeter found that injection of black bean exerted a statistically significant weight loss through reduction of body fat in compared placebo groups(1).

In the study of dried bean in reduced risk of cardiovascular disease in obese subjects, researchers found that black bean fed Sprague-Dawley rats and diet-induced obesity model in C57Bl/6 mice treated groups experienced significant weight loss through improved plasma lipid profile within a 12 d time frame.

Dr. Zhu Z, the lead author said, "These findings support the use of short-term (7-14 d) assays to investigate mechanisms that account for the cardioprotective and weight regulatory effects of dry bean and to screen dry bean germplasm resources for types of bean with high protective activity'(2).


In fact, a review literature obtained from the electronic databases PubMed, SpringerLink, Google Scholar, ScienceDirect, and MEDLINE with full text (via EBSCOHost) during late 2012 - early January 2013, showed that botanical ingredients from part of Phaseolus vulgaris and extract isolated from plants exhibited a potentially promising therapeutic effects in appetite controlled and weight loss.

Indeed, intake of high amount of dietary fiber has showed statistically significant benefits for the reduction of body weight and rick factor in developed complication, such as gallstones.

Taking together, black bean, a the common bean species hold a potential value in weigh loss and weight management through the expression of appetite controlled and prevented weight loss induced complications.

However, further studies are necessary to determine the magnitude of the effects, optimal dosage, mechanisms of action, long term safety, and potential side effects of crude extracts.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton(Scholar, Master of Nutrition, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.



Sources
(1) The efficacy of Phaseolus vulgaris as a weight-loss supplement: a systematic review and meta-analysis of randomised clinical trials by Onakpoya I1, Aldaas S, Terry R, Ernst E.(PubMed)
(2) Edible dry bean consumption (Phaseolus vulgaris L.) modulates cardiovascular risk factors and diet-induced obesity in rats and mice by Zhu Z1, Jiang W, Thompson HJ.(PubMed)
(3) A review on botanical species and chemical compounds with appetite suppressing properties for body weight control by Astell KJ1, Mathai ML, Su XQ.(PubMed)
(4) Dietary fiber's benefit for gallstone disease prevention during rapid weight loss in obese patients by Sulaberidze G1, Okujava M1, Liluashvili K1, Tughushi M1, Bezarashvili S1.(PubMed)
(5) Health Risks of Being Overweight by NIH

The Functional Herb Which Alleviates Symptoms and Treatment of Osteoarthritis With No Side Effects, Scientists Revealed

Arnica may have a substantial and positive effect in reduced risk and treatment of osteoarthritis, some scientists suggested.

Osteoarthritis (OA), a form of arthritis, is a chronic condition characterized by wear and tear on a joint due to aging, affecting over 25 million people in the United States in alone.

The University of Porto Medical School suggested that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in knee, hip and hand joints(3).

Most common symptoms of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints.

The pain usually gets worse in a change of weather, at night and in the advanced diseases, the pain can occur even at rest.


Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments.


An unhealthy diet that causes nutrient deficiency and overload, damage of cartilage, joint injury that did not heal properly, overuse, autoimmune rheumatoid arthritis also have potential effects in the increased prevalence of osteoarthritis.



Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In a randomized, double-blind study of 204 patients to investigate the effect of ibuprofen (5%) and Arnica (50 g tincture/100 g, DER 1:20), as gel preparations in patients with radiologically confirmed and symptomatically active osteoarthritis of interphalangeal joints of hands, researchers found that after 21 days of treatment, group treated with Arnica exerted a significant effect in relieve and function of the joints of hands similar to group treated with the conventional medicine.
4.8% in the Arnica group reported some tolerate adverse effects in compared to 6.1% in the group treated with ibuprofen.

After taking into account of other co and con factors, Dr. the lead researcher said, "Our results confirm that this preparation of Arnica is not inferior to ibuprofen when treating osteoarthritis of hands".


In other to confirm the effect of Arnica as a form of functional food for treatment of osteoarthritis, scientists at the Valens Clinic for Rheumatism conducted a study of the topical application of Arnica montana fresh plant gel twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee.

According to the study, treatment after 3 and 6 weeks demonstrated a strong improvement of the median total scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), used by health professionals with proprietary set of standardized questionnaires to evaluate the condition of patients with osteoarthritis, including knee and hip, including pain, stiffness, and physical functioning of the joints.


Furthermore, in regard to the symptoms expression of osteoarthritis, application of the herbal preparation exerted a significant reduction of pain, stiffness, observed by the pain and stiffness score.

A score of the mean of function subscales also showed significant reductions at these time points.


The physical function subscale found in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is considered as more consistent with a stronger test-retest reliability in compared to the pain score with some inconsistencies across the studies.

However, local tolerate adverse effects were reported in 7.6 % of patients attended the study with one patient with an allergic reaction.

Interestingly, at the end of the study, 87% rated the tolerability of the gel as "good" or "fairly good," and 76% would use it again.

These results indicated that topical application of Arnica montana gel for 6 weeks alleviated symptoms of osteoarthritis in all aspects and may be considered as a well-tolerated, and effective treatment of mild to moderate OA of the knee.


Taken together, as a topical herbal medicine, Arnica may be considered a functional food for attenuated symptoms and treatment of osteoarthritis.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study by Widrig R1, Suter A, Saller R, Melzer J.(PubMed)
(2) Arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial by Knuesel O1, Weber M, Suter A.(PubMed)
(3) The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review by Pereira D1, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E.(PubMed)

Carrot Suppressed Oxidative Stress That Causes Atherosclerosis, Cancers, Diabetes, Rheumatoid Arthritis, Post-ischemic Perfusion Injury, Myocardial Infarction, Cardiovascular Diseases,... and Stroke

Carrots may have a profound and positive effect in reduced oxidative stress in the induction of related chronic diseases, including atherosclerosis, cancers, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases,... and stroke, some scientists suggested.

Oxidative stress is the indication of overexpression free radicals in the body due to depletion of antioxidants produced by the host tissue.

According to the Department of Biotechnology, M. J. College, "Overproduction of free radicals can cause oxidative damage to biomolecules, (lipids, proteins, DNA), eventually leading to many chronic diseases".

The studies of carrots in reduced overproduction of reactive oxygen species in facilitated oxidative stress were carried out by several respectable institutes and the results were published online medical literature.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.


In the investigation of the relation of dietary supplementation with lycopene (LYC), a major active biochemical compound found in carrot, on age-induced cognitive impairment, and the potential underlying mechanisms, using the behavioral tests, researchers at Northwest A&F University, researchers found that chronic injection of LYC exerts a potential effect in alleviated age-associated memory loss and cognitive defects through several mechanisms


Application of lycopene improved antioxidant produced by the host body in countering to the overexpression of free radicals, including glutathione, catalase, and superoxide dismutase activities and the levels of antioxidant-enzyme.


Treatment of the phytochemical displayed a strong activity in reversed age-associated neuronal damage and synaptic dysfunctions in the brain, through inhibited the levels of malondialdehyde (MDA) levels in associated to oxidative stress.

Malondialdehyde (MDA) levels are considered as oxidative maker used in the treatment of cancers and other oxidative related diseases.

Interestingly, researchers also indicated that chronic injection of bioactive lycopene lowers the levels of the accumulation of Aβ1-42 in the brains in aged CD-1 mice model.



Evidence findings suggested that Aβ-induced oxidative stress may place the majority of the causative effect of increased cellular oxidative stress upon oligomeric Aβ(1–42).



Furthermore, LYC supplementation also significantly reduced age-associated neuroinflammation caused by overexpression of free radicals in the activation of proinflammatory cytokines by inhibiting microgliosis (Iba-1) in response to damage to the central nervous system (CNS) and related inflammatory chemicals mediators.

These results overwhelmingly suggested that lycopene injection processes a strong effect in reduced risk and treatment of diseases associated with overproduction of ROS, through re-balancing the ratio of antioxidant and free radicals in the host body.


Moreover, in d-galactose-induced CD-1 male mice cognitive impairments, chronic LYC supplementation (50 mg/kg body weight per day) demonstrated a significant activity in inhibition of oxidative stress-induced cognitive defects.

Injection of lycopene also ameliorated histopathological damage and restored brain-derived neurotrophic factor (BDNF) levels in the hippocampus of mice. These findings reaffirms the conclusion of the Northwest A&F University study.


LYC treatment in an animal model also increased antioxidant of the host by activating the mRNA expressions of antioxidant enzymes HO-1 and NQO-1, and inhibited the oxidative stress in the induction of inflammatory cytokines IL-1β and TNF-α in host hippocampus.


More precisely, LYC attenuated neuronal oxidative damage through activation of Nrf2 signaling in increased levels of anti-inflammatory cytokines and inactivation of NF-κB translocation in signaling pro-inflammatory expression.

Dr. Zhao B, the lead scientist, after taking into account of co and confounders said, " LYC could ameliorate oxidative stress-induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-κB transcriptional pathway".

The findings indicated that carrot with major active compound lycopene may be considered as functional foods in prevention and treatment of oxidative related diseases by restoring the ratio of reactive oxygen species and levels of antioxidant in the body.



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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice by Zhao B1, Liu H1, Wang J1, Liu P1, Tan X1, Ren B1, Liu Z1, Liu X(PubMed)
(2) Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X2(PubMed)

The Beverage Inhibits A Cluster Conditions That Cause Metabolic Syndrome, Scientists Reveal

A recent study conducted by some renowned institutes suggested that regular drinking of green tea may inhibit the early onset of metabolic syndrome.

Metabolic syndrome is a cluster condition associated to increase the risk of heart disease, stroke, and diabetes, including abnormal high blood pressure, high blood sugar and cholesterol together with excess body fat around the waist.

People with 3 of the above medical conditions are considered to have metabolic syndrome.

According to statistic, approximately, 25% of US adult population has metabolic syndrome.

Some researchers suggested that the syndrome is also associated to the condition of obesity as they share a similar component of insulin resistance.

Truly, the syndrome is not caused by a single condition but associated to a collection of risk factors,
including increases with age. race, obesity, diabetes and other diseases (cardiovascular disease, nonalcoholic fatty liver disease or polycystic ovary syndrome).

According to the joint study lead by the University of South Florida Morsani College of Medicine in investigated the prevalence of metabolic syndrome (MetS) and its components among U.S. adults, using the National Health and Nutrition Examination Survey 2007-2014 data suggested, ".... from 2007 to 2014, the prevalence of MetS remained stable in all sex, age, and race/ethnicity groups. Among the components of MetS, the prevalence of hypertriglyceridemia and fasting hyperglycemia decreased". and "The prevalence of elevated blood pressure and low high-density lipoprotein cholesterol level remained stable"(4).

Further analysis of the data, scientists found that the prevalence of abdominal obesity continues to increase in women, that can have a strong and lifelong impact in the induction of higher risk of metabolic syndrome.


Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

In a cross-sectional population-based survey including 8,821 adults (51.4% female) conducted in Krakow, Poland., both coffee and tea drinkers showed a negatively associated with MetS (OR 0.75, 95% CI 0.66, 0.86 and OR 0.79, 95% CI 0.67, 0.92, respectively).

The study also found that high tea consumers had lower BMI, waist circumference, but moderated decreased diastolic blood pressure, as well as negatively correlated central obesity and fasting plasma glucose in women, but not in men, in compared low drinker,


Furthermore, in the study including 8821 adults (51.4 % female), using food frequency questionnaires and matching food consumption data with the Phenol-Explorer database.conducted in Kraków, Poland, dietary polyphenol intake, a major compound found in green tea was associated inversely to the development of MetS (OR 0.80; 95 % CI 0.64, 0.98 and OR 0.70; 95 % CI 0.56, 0.86 for both men and women, respectively) in the highest quartile.

Dietary polyphenols in high quality also showed a negative association of WC, blood pressure, high lipoprotein cholesterol, and triglycerides in women, and fasting plasma glucose in both gender..

Dr. Grosso G, the lead author said, "(Depending to types of polyphenols) phenolic acids and stilbenes were significantly associated with MetS; lignans and stilbenes with WC; phenolic acids with blood pressure and triglycerides; and flavonoids with fasting plasma glucose" and " Among specific subclasses of polyphenols, hydroxycinnamic acids, flavanols, and dihydrochalcones had the most relevant role."

In support, the role of a polyphenol for treatment of Metabolic syndrome, a study of a total of 2725 participants free of hypertension at baseline tested for blood pressure or taking hypertensive medication within the last 2 weeks at 2-4-year follow-up visit was conducted by the Integrated Cancer Registry of Catania-Messina-Siracusa-Enna.

The final results showed that diet of highest quartile of total polyphenol intake was associated with 31% decreased the risk of hypertension compared with the lowest intake (OR 0.69, 95% CI 0.48, 0.98) in women with no significant association in men.

The study also stated that most influential phytochemicals in reduced risk and treatment of metabolic syndrome ingredients are phenolic acids, hydroxycynnamic acids as they showed a independently associated to lower odds of hypertension (OR 0.66, 95% CI 0.47, 0.93) in comparison to others.


Taking together, green tea with major chemical compounds of polyphenol may be used as functional foods in inhibited a cluster of conditions which associated to the onset of metabolic syndrome.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, s

Sources
(1) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3.(PubMed)
(2) Dietary polyphenols are inversely associated with metabolic syndrome in Polish adults of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Stefler D4, Bobak M4, Pająk A3.(PubMed)
(3) Dietary polyphenol intake and risk of hypertension in the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Kozela M3, Stefler D4, Bobak M4, Pajak A3.(PubMed)
(4) Trends in the prevalence of metabolic syndrome and its components in the United States 2007-2014 by Shin D1, Kongpakpaisarn K2, Bohra C(PubMed)