Green tea may have a therapeutic and positive effect in reducing the symptoms, risk, progression, and treatment of polymyalgia rheumatica (PMR), some scientists suggested.
Polymyalgia rheumatica an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.
The exact causes of polymyalgia rheumatica are unknown. However, researchers do know that certain prevalent risk factors are associated with the onset of diseases, such as age, family history, gender, ethnicity and exposure to environmental weather.
Genetic mutations inherited from the parents are also the major risk factor for the development of polymyalgia arthritis such as ICAM-1 (intercellular adhesion molecule 1), RANTES (regulated upon activation, normal T cell expressed, and presumably secreted).
It is important to know that Giant cell arteritis (GCA) (temporal arteritis) and polymyalgia rheumatica (PMR) share the common identity, frequently related conditions in people generally over 50 years of age, according to the Dr. Miguel A Gonzalez-Gay in the study of " Genetic epidemiology: Giant cell arteritis and polymyalgia rheumatica".
Symptoms of PMR are depending on the severity of the condition, including aches or pain shoulders, neck, upper arms, buttocks, hips or thighs, and stiffness in affected areas.
People with PMR also experience pain in the morning or after being inactive for a time, limited range of motion in the affected areas.
If you have some of the above symptoms, please check with your doctor to rule out the PMR possibility.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
In an animal study of inflammatory diseases induced by injection of LPS, researchers found that application of green tea bioactive polyphenols EGCG improves antioxidant status of the host and decreases the production of inflammatory factors, including PMR through its antioxidant properties.
Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, swelling of the infectious site without affecting the function of immune system in the protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.
The bioactive compound also inhibited reactive oxygen species (ROS) in stimulating the production of inflammatory cytokines through stopping the free radicals chain reactions that facilitate inflammation and the precipitate skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue.
In fact, overproduction of ROS increased expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases can cause an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.
The further evaluation suggested that green tea EGCG also reduced expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.
Long-term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complications of several chronic inflammatory diseases through the generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,
Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in the regulation of innate and adaptive immune functions and served as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor alpha (TNF-α) in promoting muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.
Importantly, application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.
These actions together with antioxidant initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues and prevented muscle tension to precipitate polymyalgia arthritis.
Deficiency of glutathione levels was found to associate to the early onset of polymyalgia rheumatica, inducing symptoms of pain, stiffness, achiness, fatigue, and fever.
Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drugs with the function to target pro-inflammation cytokines in the relieved stiffness and pain in patients with polymyalgia arthritis.
Taken all together, green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression and treatment of polymyalgia rheumatica(PMR).
However, ingestion green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literatures.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3. (PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM. (PubMed)
Sunday, January 27, 2019
Saturday, January 26, 2019
Maternal Coffee Intake > 4 Cups/Day May Increase Risk of Miscarriage, Scientists Suggest
The risk of miscarrying is increased substantially in excessive (over 4 cups/day) coffee drinkers during pregnancy, an Asian study suggested.
A miscarriage, according to the definition is the loss of a fetus before the 20th week of pregnancy.
Believe or not, according to medical literature, as many as many as 50% of all pregnancies end in miscarriage and over 80% of miscarriages are occurring within the first three months of pregnancy.
Some researchers suggested that women who carry mutation genes associated with chromosome gains and losses during embryonic development can lead to miscarriage or the failure of IVF treatments.
Other risk factors associated with an increased risk of miscarriage include aging Age. Women who are older than age 35, previous miscarriages. smoking and excessive alcohol drinking before and during pregnancy have a higher risk of miscarriage compared to younger women,
Chronic medical health conditions such as obesity and uterine or cervical problems can also substantially increase the miscarriage risk.
Coffee, one of the most popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
In a case-controlled study conducted in Milan of 561 (72%) cases of spontaneous abortion and 877 (57%) controls, coffee drinking during the first trimester of the index pregnancy with healthy women who gave birth at term (> 37 weeks gestation) to healthy infants as control, researchers reported that the risk of miscarry is classified as follows
* Coffee intake of 1, 2 or 3, and 4 or more cups of coffee per day are associated with an increased risk of 1.2, 1.8 and 4.0, respectively, compared to nondrinkers.
* The risk of pregnancy loss also is associated with the duration in years of coffee drinking. The estimated multivariate odds ratios of spontaneous abortion were 1.1 in comparison to non-coffee intake group.
Furthermore, in the evaluated effect of caffeine in influence of miscarriage researchers at the Boston University School of Public Health, conducted a prospective cohort study included 5132 Danish women planning pregnancy, enrolled from 2007 to 2010, after carefully assessed the returned beverage consumption on questionnaires, researcher found that a significantly miscarried risk is 1.62 higher in women consuming more than 300 mg/day of caffeine per day, in compared to 1.09 in women who consume <100 mg/day. Specifically, women with daily intake of caffeine of
* <100 mg/day showed a materially associated with SAB risk of 1.09.
* 100-199mg/day showed a materially associated with SAB risk of 0,89.
* 200-299mg/day showed a materially associated with SAB risk of 1.33
Additionally, in prospective cohort study included 15,590 pregnancies from 11,072 women with no history of SAB in the Nurses' Health Study II (1991-2009) with beverage intake assessed every 4 years using a validated questionnaire in case pregnancies lost spontaneously at <20 weeks gestation, total coffee intake had a positive, linear association with SAB.
In compared to non-pre-pregnancy coffee intake, the risk of SAB increased by 20% for women consuming ≥4 servings/day.
More importantly, Dr. Gaskins AJ, the lead author said, "Pre-pregnancy coffee consumption at levels ≥4 servings/day is associated with the increased risk of SAB, particularly at weeks 8-19".
Taking together, there is no doubt that coffee may contribute to a relative risk of miscarrying for women consuming more than 4 cups per day.
Women who are pregnant between 12 to 28 weeks of gestation with excessive coffee intake habit are recommended to consult with their doctors.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation by Parazzini F1, Chatenoud L, Di Cintio E, Mezzopane R, Surace M, Zanconato G, Fedele L, Benzi G.(PubMed)
(2) Caffeine and caffeinated beverage consumption and risk of spontaneous abortion by Hahn KA1, Wise LA2, Rothman KJ3, Mikkelsen EM4, Brogly SB5, Sørensen HT6, Riis AH4, Hatch EE5.(PubMed)
(3) Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion by Gaskins AJ1,2, Rich-Edwards JW3,4,5, Williams PL3,6, Toth TL7, Missmer SA3,4,8,9, Chavarro JE10,3,4.(PubMed)
A miscarriage, according to the definition is the loss of a fetus before the 20th week of pregnancy.
Believe or not, according to medical literature, as many as many as 50% of all pregnancies end in miscarriage and over 80% of miscarriages are occurring within the first three months of pregnancy.
Some researchers suggested that women who carry mutation genes associated with chromosome gains and losses during embryonic development can lead to miscarriage or the failure of IVF treatments.
Other risk factors associated with an increased risk of miscarriage include aging Age. Women who are older than age 35, previous miscarriages. smoking and excessive alcohol drinking before and during pregnancy have a higher risk of miscarriage compared to younger women,
Chronic medical health conditions such as obesity and uterine or cervical problems can also substantially increase the miscarriage risk.
Coffee, one of the most popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
In a case-controlled study conducted in Milan of 561 (72%) cases of spontaneous abortion and 877 (57%) controls, coffee drinking during the first trimester of the index pregnancy with healthy women who gave birth at term (> 37 weeks gestation) to healthy infants as control, researchers reported that the risk of miscarry is classified as follows
* Coffee intake of 1, 2 or 3, and 4 or more cups of coffee per day are associated with an increased risk of 1.2, 1.8 and 4.0, respectively, compared to nondrinkers.
* The risk of pregnancy loss also is associated with the duration in years of coffee drinking. The estimated multivariate odds ratios of spontaneous abortion were 1.1 in comparison to non-coffee intake group.
Furthermore, in the evaluated effect of caffeine in influence of miscarriage researchers at the Boston University School of Public Health, conducted a prospective cohort study included 5132 Danish women planning pregnancy, enrolled from 2007 to 2010, after carefully assessed the returned beverage consumption on questionnaires, researcher found that a significantly miscarried risk is 1.62 higher in women consuming more than 300 mg/day of caffeine per day, in compared to 1.09 in women who consume <100 mg/day. Specifically, women with daily intake of caffeine of
* <100 mg/day showed a materially associated with SAB risk of 1.09.
* 100-199mg/day showed a materially associated with SAB risk of 0,89.
* 200-299mg/day showed a materially associated with SAB risk of 1.33
Additionally, in prospective cohort study included 15,590 pregnancies from 11,072 women with no history of SAB in the Nurses' Health Study II (1991-2009) with beverage intake assessed every 4 years using a validated questionnaire in case pregnancies lost spontaneously at <20 weeks gestation, total coffee intake had a positive, linear association with SAB.
In compared to non-pre-pregnancy coffee intake, the risk of SAB increased by 20% for women consuming ≥4 servings/day.
More importantly, Dr. Gaskins AJ, the lead author said, "Pre-pregnancy coffee consumption at levels ≥4 servings/day is associated with the increased risk of SAB, particularly at weeks 8-19".
Taking together, there is no doubt that coffee may contribute to a relative risk of miscarrying for women consuming more than 4 cups per day.
Women who are pregnant between 12 to 28 weeks of gestation with excessive coffee intake habit are recommended to consult with their doctors.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Coffee consumption and risk of hospitalized miscarriage before 12 weeks of gestation by Parazzini F1, Chatenoud L, Di Cintio E, Mezzopane R, Surace M, Zanconato G, Fedele L, Benzi G.(PubMed)
(2) Caffeine and caffeinated beverage consumption and risk of spontaneous abortion by Hahn KA1, Wise LA2, Rothman KJ3, Mikkelsen EM4, Brogly SB5, Sørensen HT6, Riis AH4, Hatch EE5.(PubMed)
(3) Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion by Gaskins AJ1,2, Rich-Edwards JW3,4,5, Williams PL3,6, Toth TL7, Missmer SA3,4,8,9, Chavarro JE10,3,4.(PubMed)
Friday, January 25, 2019
Carrots, the Veggies with Anti Cancer Potential, Researchers Find
Carrot, the root veggie may have a potential and positive effect in blocking the proliferation of cancer cells, some scientists suggested.
Cancer is a class of chronic and medical diseases characterized by irregular and disordered cell growth in one or some tissue and organs in the body.
Most cancers start from the inner lining of the tissue of the organs then slowly spread to the deeper parts of the infected organs. At the advanced stage, most malignant cancer cells can travel a distance away from the original site to infect other healthy tissue and organs.
Most cancer diagnosed in the early have a 100% 5 years survival rate.
According to the statistic provided by the Canadian public health service, during their lifetime, nearly 1 in 2 Canadians will be diagnosed with cancer, and 1 in 4 will die from the disease.
Lung, colorectal, breast and prostate cancers account for half of all cancers diagnosed in Canada and over 25% of all cancer deaths in Canada are due to lung cancer.
The causes of cancers are unknown, however, scientists in the world agreed that there are several risk factors such as gene mutations inherited from the parents and acquired gene mutations caused by smoking, radiation, viruses, chemicals carcinogens, obesity, hormones, chronic inflammation, and physical inactivity are associated to the early onset of cancer.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.
In the investigation of the claim of Lebanese folk medicine that Daucus carota, also known as wild carrot has a potency for treatment of various types of cancer, researchers at the Lebanese American University, conducted an experience to identify the major compound responsible for the anti-cancer activity of DCOE.
β-2-himachalen-6-ol, a novel sesquiterpene unique to β-2-Himachalen-6-ol isolated from the Lebanese wild carrot demonstrated potent anti-cancer activity against B16F-10, Caco-2, MB-MDA-231, A549, and SF-268 cancer cells (IC50 13-4µg/ml; 58-18µM), and SF-268 cells.
Furthermore, the sesquiterpene was shown to induce cell death through apoptosis (flow cytometry), decrease 2D cell motility (wound healing assay) and 3D invasion, as well as increase cell adhesion in SF-268 cells.
Additionally, β-2-himachalen-6-ol showed very low toxicity.
These results suggested that wild carrot β-2-himachalen-6-ol may have a potential multi-mechanistic chemotherapeutic drug with high potency and safety.
Moreover, in the concerns of the mortality rate caused by gastric cancer, researchers at the Shahid Sadoughi University of Medical Sciences conducted a review by searching the multiple databases including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx to determine the relationship between carrot consumption and gastric cancer.
Out of 81 articles found in the databases, only 5 studies satisfied the medical guidelines and criteria were included in the review. after taking into account co and confounders, researchers found that
* Intake of carrot regularly reduced the risk of gastric cancer by 26%.
* There is an inverse relationship between the consumption of carrots and the risk of gastric cancer.
More interestingly, regarding the inconsistent results. associated with carrot intake and prostate cancer risk, researchers at the Zhejiang University also launched a review by searching the databases of PubMed, EMBASE, Scopus, Web of Science, the Cochrane register, and the Chinese National Knowledge Infrastructure to determine whether intake of carrot may reduce the risk of prostate cancer.
At the final report, researchers found that
* Intake of carrot is associated with a significantly decreased risk of prostate cancer with the odds ratio of 0.82 which is consistency with the Shahid Sadoughi University of Medical Sciences study.
* Forr each serving per week or 10 g per day increment of carrot intake, the odds ratio of the risk of prostate cancer was 0.95, according to the dose-response meta-analysis.
The findings indicated that intake of carrot may have a potential effect in reducing the risk of the onset of cancers.
However, due to the limited number of cohort studies and substantial heterogeneity observed between studies in this meta-analysis, further well-designed prospective studies are warranted to confirm the findings from the studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1)β-2-himachalen-6-ol: A novel anticancer sesquiterpene unique to the Lebanese wild carrot by Taleb RI1, Najm P2, Shebaby W2, Boulos JC2, Demirdjian S2, Hariri E2, El-Sibai M2, Daher C2, Mroueh M3(PubMed)
(2) Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis by Fallahzadeh H1, Jalali A2, Momayyezi M1, Bazm S3.(PubMed)
(3) Dietary carrot consumption and the risk of prostate cancer. by Xu X1, Cheng Y, Li S, Zhu Y, Xu X, Zheng X, Mao Q, Xie L.(PubMed)
Cancer is a class of chronic and medical diseases characterized by irregular and disordered cell growth in one or some tissue and organs in the body.
Most cancers start from the inner lining of the tissue of the organs then slowly spread to the deeper parts of the infected organs. At the advanced stage, most malignant cancer cells can travel a distance away from the original site to infect other healthy tissue and organs.
Most cancer diagnosed in the early have a 100% 5 years survival rate.
According to the statistic provided by the Canadian public health service, during their lifetime, nearly 1 in 2 Canadians will be diagnosed with cancer, and 1 in 4 will die from the disease.
Lung, colorectal, breast and prostate cancers account for half of all cancers diagnosed in Canada and over 25% of all cancer deaths in Canada are due to lung cancer.
The causes of cancers are unknown, however, scientists in the world agreed that there are several risk factors such as gene mutations inherited from the parents and acquired gene mutations caused by smoking, radiation, viruses, chemicals carcinogens, obesity, hormones, chronic inflammation, and physical inactivity are associated to the early onset of cancer.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.
In the investigation of the claim of Lebanese folk medicine that Daucus carota, also known as wild carrot has a potency for treatment of various types of cancer, researchers at the Lebanese American University, conducted an experience to identify the major compound responsible for the anti-cancer activity of DCOE.
β-2-himachalen-6-ol, a novel sesquiterpene unique to β-2-Himachalen-6-ol isolated from the Lebanese wild carrot demonstrated potent anti-cancer activity against B16F-10, Caco-2, MB-MDA-231, A549, and SF-268 cancer cells (IC50 13-4µg/ml; 58-18µM), and SF-268 cells.
Furthermore, the sesquiterpene was shown to induce cell death through apoptosis (flow cytometry), decrease 2D cell motility (wound healing assay) and 3D invasion, as well as increase cell adhesion in SF-268 cells.
Additionally, β-2-himachalen-6-ol showed very low toxicity.
These results suggested that wild carrot β-2-himachalen-6-ol may have a potential multi-mechanistic chemotherapeutic drug with high potency and safety.
Moreover, in the concerns of the mortality rate caused by gastric cancer, researchers at the Shahid Sadoughi University of Medical Sciences conducted a review by searching the multiple databases including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx to determine the relationship between carrot consumption and gastric cancer.
Out of 81 articles found in the databases, only 5 studies satisfied the medical guidelines and criteria were included in the review. after taking into account co and confounders, researchers found that
* Intake of carrot regularly reduced the risk of gastric cancer by 26%.
* There is an inverse relationship between the consumption of carrots and the risk of gastric cancer.
More interestingly, regarding the inconsistent results. associated with carrot intake and prostate cancer risk, researchers at the Zhejiang University also launched a review by searching the databases of PubMed, EMBASE, Scopus, Web of Science, the Cochrane register, and the Chinese National Knowledge Infrastructure to determine whether intake of carrot may reduce the risk of prostate cancer.
At the final report, researchers found that
* Intake of carrot is associated with a significantly decreased risk of prostate cancer with the odds ratio of 0.82 which is consistency with the Shahid Sadoughi University of Medical Sciences study.
* Forr each serving per week or 10 g per day increment of carrot intake, the odds ratio of the risk of prostate cancer was 0.95, according to the dose-response meta-analysis.
The findings indicated that intake of carrot may have a potential effect in reducing the risk of the onset of cancers.
However, due to the limited number of cohort studies and substantial heterogeneity observed between studies in this meta-analysis, further well-designed prospective studies are warranted to confirm the findings from the studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1)β-2-himachalen-6-ol: A novel anticancer sesquiterpene unique to the Lebanese wild carrot by Taleb RI1, Najm P2, Shebaby W2, Boulos JC2, Demirdjian S2, Hariri E2, El-Sibai M2, Daher C2, Mroueh M3(PubMed)
(2) Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis by Fallahzadeh H1, Jalali A2, Momayyezi M1, Bazm S3.(PubMed)
(3) Dietary carrot consumption and the risk of prostate cancer. by Xu X1, Cheng Y, Li S, Zhu Y, Xu X, Zheng X, Mao Q, Xie L.(PubMed)
Thursday, January 24, 2019
Green Tea Protects the Child Joints Against the Onset of Juvenile Arthritis
Green tea may have a therapeutic and positive effect in reducing risk, progression, and treatment of juvenile arthritis, some scientists suggested.
Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.
In other words, it is an autoimmune disorder caused by the immune system attacks some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.
Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.
According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.
Juvenile Arthritis shares the common symptoms of adult arthritis, including pain, stiffness, swelling, fever, skin rash and in the serious case. The condition can also cause some complications such as pericarditis, hemolytic anemia, macrophage activation syndrome (MAS), and endarteritis
In the article "Juvenile Arthritis: Early Signs and Symptoms" By Susan Bernstein wrote, "Juvenile arthritis includes many different diseases, but one common thread between them is that they can have serious, even life-threatening impacts on a young child".
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
In the investigation of the effect of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, a model for human rheumatoid arthritis with daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days, researchers at the State University of Maringá, found that treatment group expressed a significant activity in reducing the protein and lipid damage in liver, brain, and plasma, caused by ROS expression in induction of oxidation which has been found with associated to the progression of arthritis.
Injection of green tea extract also enhanced the overexpression of antioxidant defenses, found in low levels in patients with arthritis through restoration of the glutathione (GSH) associated to the important function in preventing damage to important cellular components caused by reactive oxygen species and protein thiol levels in reducing cellular oxidation through chelative and detoxified activities and improved natural antioxidant enzymes, produced by the body.
Furthermore, green tea extract also inhibited the levels of glucose 6-phosphate dehydrogenase, which is increased in the liver in patients with arthritis, one of the major risk factor for the development of arthritis.
These results suggested that application of green tea exerted a significantly profound effect in the liver and brain of patients suffering from rheumatoid arthritis through reduced overexpression of oxidative stress in precipitated injury to lipids and proteins.
Some researchers suggested that by modifying the metabolic function in lipid and protein, green tea extract exhibited a strong protective effect in reducing the symptoms and progression of arthritis.
According to the study of University of Health System of green tea effect in patients with rheumatoid
arthritis, injection of green tea extract demonstrated a therapeutic effect in patient's synovial fibroblast of the lining tissue which surround the capsule of the joint by inhibiting the production of IL-1B, a prototypic proinflammatory cytokines in response to acute and chronic inflammation. Overexpression of IL-1B is associated with the contribution of joint damage.
Interestingly, in the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), researchers indicated that application of tea significant inhibits the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.
Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.
Due to the limitation of the study, Dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".
More importantly, in the examine some major factors in contributing juvenile arthritis, green tea rich in catechins (Healthy green tea) in animal study, green tea injection restored these biomarkers of cytokine genes (IL-1A, IL-2, IFN-alpha, FGF-alpha, TNF-alpha) to near normal levels, thus preventing or attenuating the development of a certain type of inflammatory arthritis.
Taken all together, green tea and its bioactive polyphenols may be considered a functional food for reduction of the early onset, progression and combined with standard therapy for treatment of juvenile and adult arthritis.
However, the intake of green tea supplement should be taken with exceptional care as acute liver toxicity has been reported in numbers of medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM. (PubMed)
(2) (Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(3) Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver by Abe K1, Ijiri M, Suzuki T, Taguchi K, Koyama Y, Isemura M.(PubMed)
Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.
In other words, it is an autoimmune disorder caused by the immune system attacks some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.
Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.
According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.
Juvenile Arthritis shares the common symptoms of adult arthritis, including pain, stiffness, swelling, fever, skin rash and in the serious case. The condition can also cause some complications such as pericarditis, hemolytic anemia, macrophage activation syndrome (MAS), and endarteritis
In the article "Juvenile Arthritis: Early Signs and Symptoms" By Susan Bernstein wrote, "Juvenile arthritis includes many different diseases, but one common thread between them is that they can have serious, even life-threatening impacts on a young child".
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
In the investigation of the effect of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, a model for human rheumatoid arthritis with daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days, researchers at the State University of Maringá, found that treatment group expressed a significant activity in reducing the protein and lipid damage in liver, brain, and plasma, caused by ROS expression in induction of oxidation which has been found with associated to the progression of arthritis.
Injection of green tea extract also enhanced the overexpression of antioxidant defenses, found in low levels in patients with arthritis through restoration of the glutathione (GSH) associated to the important function in preventing damage to important cellular components caused by reactive oxygen species and protein thiol levels in reducing cellular oxidation through chelative and detoxified activities and improved natural antioxidant enzymes, produced by the body.
Furthermore, green tea extract also inhibited the levels of glucose 6-phosphate dehydrogenase, which is increased in the liver in patients with arthritis, one of the major risk factor for the development of arthritis.
These results suggested that application of green tea exerted a significantly profound effect in the liver and brain of patients suffering from rheumatoid arthritis through reduced overexpression of oxidative stress in precipitated injury to lipids and proteins.
Some researchers suggested that by modifying the metabolic function in lipid and protein, green tea extract exhibited a strong protective effect in reducing the symptoms and progression of arthritis.
According to the study of University of Health System of green tea effect in patients with rheumatoid
arthritis, injection of green tea extract demonstrated a therapeutic effect in patient's synovial fibroblast of the lining tissue which surround the capsule of the joint by inhibiting the production of IL-1B, a prototypic proinflammatory cytokines in response to acute and chronic inflammation. Overexpression of IL-1B is associated with the contribution of joint damage.
Interestingly, in the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), researchers indicated that application of tea significant inhibits the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.
Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.
Due to the limitation of the study, Dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".
More importantly, in the examine some major factors in contributing juvenile arthritis, green tea rich in catechins (Healthy green tea) in animal study, green tea injection restored these biomarkers of cytokine genes (IL-1A, IL-2, IFN-alpha, FGF-alpha, TNF-alpha) to near normal levels, thus preventing or attenuating the development of a certain type of inflammatory arthritis.
Taken all together, green tea and its bioactive polyphenols may be considered a functional food for reduction of the early onset, progression and combined with standard therapy for treatment of juvenile and adult arthritis.
However, the intake of green tea supplement should be taken with exceptional care as acute liver toxicity has been reported in numbers of medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM. (PubMed)
(2) (Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(3) Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver by Abe K1, Ijiri M, Suzuki T, Taguchi K, Koyama Y, Isemura M.(PubMed)
Wednesday, January 23, 2019
Carrot Promotes Weight Loss and Prevents the Onset of Obesity
Carrots may have a profound and positive effect in reducing weight loss in the obese population, some scientists suggested.
Weight loss is an intentional action referred by the medicine, health, or physical fitness communities as a reduction of the total body mass, including loss of fluid, body fat or adipose tissue or lean mass.
Obesity is a condition or disease characterized by extreme overweight. According to the Body Mass Index calculator, BMI between 25.0 to <30 is considered overweight and BMI of 30.0 or higher, is considered obese.
According to the National Institue of Health, obese people are associated with numbers of diseases and conditions, including diseases of coronary heart disease, type 2 diabetes, certain types of cancer, stroke, gallbladder disease, liver disease, certain types of respiratory disease and infertility and conditions of high blood pressure, high total cholesterol or high levels of triglycerides, sleep apnea and osteoarthritis.
Most researchers agreed that obesity is caused by a genetic mutation inherited from the parents, a longterm unhealthy diet with consumption of high amounts of energy foods, particularly fat and sugars and physical inactivity.
Other causable factors also include certain medical conditions such as hypothyroidism and Cushing's syndrome and long-term use of certain medication such as corticosteroids and antidepressant.
The general belief also suggested that some smokers may gain weight if they quit smoking.
According to the study conducted by the J University of Georgia, using a combined approach to promote nutrition and physical activity policies and practices in the early care and education may reduce the risk of child obesity.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.
Estrogen-deficient animals with diet-induced obesity were examined in the study by the Obesity/Diabetes Center, Asan, Korea using black carrots to test the mechanisms of the long-term consumption of unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) or Aspergillus oryzae (BCAO) in the prevention of menopausal symptoms including impaired energy, glucose and lipid metabolism
During the experiment, ovariectomized (OVX) rats were fed four different high-fat diets containing 2 % dextrin (OVX-control), 2 % BC, 2 % BCLP, or 2 % BCAO for 12 weeks. Sham rats were fed high-fat diets containing 2 % dextrin.
Fat mass and weight gain in tested mice were lower in descending order of OVX-control > BC and BCLP > BCAO due to increased energy expenditure and fat oxidation.
BC, BCLP and especially BCAO all normalized HOMA-IR, an indicator of insulin resistance and glucose intolerance.
Furthermore, BCAO markedly decreased hepatic triglyceride levels by increasing gene expressions of CPT-1 and PPAR-α, which are involved in fatty acid oxidation, and decreasing mRNA expressions of FAS and SREBP-1c, which are associated with fatty acid synthesis.
More importantly, Cyanidin and malvidin markedly decreased fat accumulation in 3T3-L1 adipocytes by increasing CPT-1 and decreasing FAS expression in the liver fat metabolism and SREBP-1c expression in the regulation of the genes with the function of lipid metabolism in comparison with cyanidin-3-rutinoside, an anthocyanin, and malvidin-3,5-diglycosides, another anthocyanidin.
Where 3T3-L1 is a cell line derived from 3T3 cells used in biological research on adipose tissue.
These results suggested that unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) processed anti-obesity mechanism by preventing the exacerbation of lipid and glucose metabolism, the major's causes of weight gain.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of carrot's anti-weight gain possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid, and glucose metabolism in estrogen-deficient rats by AMPK activation by Park S1, Kang S, Jeong DY, Jeong SY, Park JJ, Yun HS. (PubMed)
Weight loss is an intentional action referred by the medicine, health, or physical fitness communities as a reduction of the total body mass, including loss of fluid, body fat or adipose tissue or lean mass.
Obesity is a condition or disease characterized by extreme overweight. According to the Body Mass Index calculator, BMI between 25.0 to <30 is considered overweight and BMI of 30.0 or higher, is considered obese.
According to the National Institue of Health, obese people are associated with numbers of diseases and conditions, including diseases of coronary heart disease, type 2 diabetes, certain types of cancer, stroke, gallbladder disease, liver disease, certain types of respiratory disease and infertility and conditions of high blood pressure, high total cholesterol or high levels of triglycerides, sleep apnea and osteoarthritis.
Most researchers agreed that obesity is caused by a genetic mutation inherited from the parents, a longterm unhealthy diet with consumption of high amounts of energy foods, particularly fat and sugars and physical inactivity.
Other causable factors also include certain medical conditions such as hypothyroidism and Cushing's syndrome and long-term use of certain medication such as corticosteroids and antidepressant.
The general belief also suggested that some smokers may gain weight if they quit smoking.
According to the study conducted by the J University of Georgia, using a combined approach to promote nutrition and physical activity policies and practices in the early care and education may reduce the risk of child obesity.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asian and Europe.
Estrogen-deficient animals with diet-induced obesity were examined in the study by the Obesity/Diabetes Center, Asan, Korea using black carrots to test the mechanisms of the long-term consumption of unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) or Aspergillus oryzae (BCAO) in the prevention of menopausal symptoms including impaired energy, glucose and lipid metabolism
During the experiment, ovariectomized (OVX) rats were fed four different high-fat diets containing 2 % dextrin (OVX-control), 2 % BC, 2 % BCLP, or 2 % BCAO for 12 weeks. Sham rats were fed high-fat diets containing 2 % dextrin.
Fat mass and weight gain in tested mice were lower in descending order of OVX-control > BC and BCLP > BCAO due to increased energy expenditure and fat oxidation.
BC, BCLP and especially BCAO all normalized HOMA-IR, an indicator of insulin resistance and glucose intolerance.
Furthermore, BCAO markedly decreased hepatic triglyceride levels by increasing gene expressions of CPT-1 and PPAR-α, which are involved in fatty acid oxidation, and decreasing mRNA expressions of FAS and SREBP-1c, which are associated with fatty acid synthesis.
More importantly, Cyanidin and malvidin markedly decreased fat accumulation in 3T3-L1 adipocytes by increasing CPT-1 and decreasing FAS expression in the liver fat metabolism and SREBP-1c expression in the regulation of the genes with the function of lipid metabolism in comparison with cyanidin-3-rutinoside, an anthocyanin, and malvidin-3,5-diglycosides, another anthocyanidin.
Where 3T3-L1 is a cell line derived from 3T3 cells used in biological research on adipose tissue.
These results suggested that unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) processed anti-obesity mechanism by preventing the exacerbation of lipid and glucose metabolism, the major's causes of weight gain.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of carrot's anti-weight gain possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid, and glucose metabolism in estrogen-deficient rats by AMPK activation by Park S1, Kang S, Jeong DY, Jeong SY, Park JJ, Yun HS. (PubMed)
Tuesday, January 22, 2019
Fennel, the Best Functional Food to Normalizes Your Blood Cholesterol Quickly With No Side Effects
Scientists may have found a natural whole food with the potential to treat hyperlipidemia without inducing any side effects, some studies suggested.
Cholesterol, the natural ingredient produced in the liver plays an important role in stimulating the production of vitamin D, steroid hormones, and bile acids and maintaining healthy cell membranes.
Hyperlipidemia is a condition characterized by abnormally elevated levels of cholesterol in the plasma of the blood.
The causes of hyperlipidemia are unknown. However, an unhealthy diet with a lot of unsaturated fat and trans fat is associated with the early onset of the disease. Foods such as cheese egg yolks fried and processed foods and red meat have found to increase blood cholesterol, long-term intake of such foods in great amount have been found to increase the risk of hyperlipidemia, epidemiological studies found.
The Beni-Suef University, in the study to determine the development of obesity in response to a high-fat diet (HFD) an Egyptian Herbal mixture formulation (HMF), including fennel, showed, "feeding HFD diet significantly increased final body weight, triglycerides (TG), total cholesterol, & LDL concentration compared with controls, while significantly decreasing HD".
Hyperlipidemia is a lifelong condition which is treatable.
Dr. Robert B. Kelly at the Fairview Hospital/Cleveland Clinic Family Medicine Residency Program in the article "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet. Smaller but still beneficial effects result from reducing intake of dietary cholesterol, increasing intake of soluble fiber and soy protein, and eating fatty marine fish or taking marine-derived omega-3 fatty acid supplements".
Therefore by changing the diet pattern and engaging regular physical exercise are the fundamental
options that not only can prevent the onset of the condition, particularly in people who are at the higher risk of hyperlipidemia and also treat high blood cholesterol in patients who already have the condition.
Fennel (Foeniculum vulgare) is a plant species of a genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The plant has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS.
In the study to examine the effect of the aqueous extract of fennel in the reduced risk of hyperlipidemia, researchers conducted an experiment in Triton WR-1339 induced hyperlipidemia in mice.
Mice treated with the extract at different doses displays a significant reduction of cholesterol, triglycerides, LDL-cholesterol, and apolipoprotein-B decreased by 40%, 23%, 61%, and 61%, respectively.
Further analysis, the application also increased the levels of HDL-cholesterol and apolipoprotein A1 by 85% and 58%, respectively
According to the Mashhad University of Medical Sciences which also conducted a study to assess the effects of Fennel (Foeniculum vulgare Mill.) on lipid profiles, in sixty eligible postmenopausal women, randomly assigned into the fennel and placebo groups.
Measurement of total blood cholesterol, cholesterol fractions, and triglycerides was tested at the baseline, and after a three-month follow-up.
At the end of 3 months, blood profiled withdrawn from the women suggested
* There are no significant difference in triglyceride (P = 0.679), total cholesterol (P = 0.103), low-density lipoprotein cholesterol(LDL-C; P = 0.146) and high-density lipoprotein cholesterol (HDL-C; P = 0.266) levels between the two groups.
* Fennel treated group demonstrates a significant borderline improvement for HDL-C and triglyceride, compared to the placebo group.
Additional differentiation of the process of the double-blind, randomized and placebo-controlled trial, researchers suggested that longer durations, higher doses, and larger sample sizes are recommended to validate the results.
These results indicated that intake of foods for treatment of conditions or diseases must be on a long-term basis. The times of 3 months may be too short for foods to exert their potential effects.
Taken all together, fennel may be considered a functional food for the prevention and treatment of hyperlipidemia. Intake of fennel should be increased gradually for the food to reach its antihyperlipidemic stage, a longer duration may be needed. In other words, please be patient.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) The Effect of Short-term Treatment with Fennel on Lipid Profile in Postmenopausal Women: A Randomized Controlled Trial by Afiat M1, Amini E2, Ghazanfarpour M3, Nouri B4, Mousavi MS5, Babakhanian M6, Rakhshandeh H(PubMed)
(3) Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats by Amin KA1, Nagy M(PubMed)
Cholesterol, the natural ingredient produced in the liver plays an important role in stimulating the production of vitamin D, steroid hormones, and bile acids and maintaining healthy cell membranes.
Hyperlipidemia is a condition characterized by abnormally elevated levels of cholesterol in the plasma of the blood.
The causes of hyperlipidemia are unknown. However, an unhealthy diet with a lot of unsaturated fat and trans fat is associated with the early onset of the disease. Foods such as cheese egg yolks fried and processed foods and red meat have found to increase blood cholesterol, long-term intake of such foods in great amount have been found to increase the risk of hyperlipidemia, epidemiological studies found.
The Beni-Suef University, in the study to determine the development of obesity in response to a high-fat diet (HFD) an Egyptian Herbal mixture formulation (HMF), including fennel, showed, "feeding HFD diet significantly increased final body weight, triglycerides (TG), total cholesterol, & LDL concentration compared with controls, while significantly decreasing HD".
Hyperlipidemia is a lifelong condition which is treatable.
Dr. Robert B. Kelly at the Fairview Hospital/Cleveland Clinic Family Medicine Residency Program in the article "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet. Smaller but still beneficial effects result from reducing intake of dietary cholesterol, increasing intake of soluble fiber and soy protein, and eating fatty marine fish or taking marine-derived omega-3 fatty acid supplements".
Therefore by changing the diet pattern and engaging regular physical exercise are the fundamental
options that not only can prevent the onset of the condition, particularly in people who are at the higher risk of hyperlipidemia and also treat high blood cholesterol in patients who already have the condition.
Fennel (Foeniculum vulgare) is a plant species of a genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The plant has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS.
In the study to examine the effect of the aqueous extract of fennel in the reduced risk of hyperlipidemia, researchers conducted an experiment in Triton WR-1339 induced hyperlipidemia in mice.
Mice treated with the extract at different doses displays a significant reduction of cholesterol, triglycerides, LDL-cholesterol, and apolipoprotein-B decreased by 40%, 23%, 61%, and 61%, respectively.
Further analysis, the application also increased the levels of HDL-cholesterol and apolipoprotein A1 by 85% and 58%, respectively
According to the Mashhad University of Medical Sciences which also conducted a study to assess the effects of Fennel (Foeniculum vulgare Mill.) on lipid profiles, in sixty eligible postmenopausal women, randomly assigned into the fennel and placebo groups.
Measurement of total blood cholesterol, cholesterol fractions, and triglycerides was tested at the baseline, and after a three-month follow-up.
At the end of 3 months, blood profiled withdrawn from the women suggested
* There are no significant difference in triglyceride (P = 0.679), total cholesterol (P = 0.103), low-density lipoprotein cholesterol(LDL-C; P = 0.146) and high-density lipoprotein cholesterol (HDL-C; P = 0.266) levels between the two groups.
* Fennel treated group demonstrates a significant borderline improvement for HDL-C and triglyceride, compared to the placebo group.
Additional differentiation of the process of the double-blind, randomized and placebo-controlled trial, researchers suggested that longer durations, higher doses, and larger sample sizes are recommended to validate the results.
These results indicated that intake of foods for treatment of conditions or diseases must be on a long-term basis. The times of 3 months may be too short for foods to exert their potential effects.
Taken all together, fennel may be considered a functional food for the prevention and treatment of hyperlipidemia. Intake of fennel should be increased gradually for the food to reach its antihyperlipidemic stage, a longer duration may be needed. In other words, please be patient.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) The Effect of Short-term Treatment with Fennel on Lipid Profile in Postmenopausal Women: A Randomized Controlled Trial by Afiat M1, Amini E2, Ghazanfarpour M3, Nouri B4, Mousavi MS5, Babakhanian M6, Rakhshandeh H(PubMed)
(3) Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats by Amin KA1, Nagy M(PubMed)
Monday, January 21, 2019
Green Tea Inhibits The Excessive Uric Acid That Cause Acute and Chronic Gout
Green tea may have a therapeutic and positive effect in blocking the onset and treatment of gout and recurrent gout, some scientists suggested.
Gout is a condition of recurrently inflammatory arthritis characterized by a red, tender, hot, and swollen joint caused by overexpression of purine in the body.
Gout is caused by an excess of uric acid in the blood, or hyperuricemia. Uric acid is a by-product that is produced during the digestive process in the breaking down of chemical ingredients purines.
Purines are natural nitrogen-containing compounds found in the cell DNA and RNA, including adenine (6-aminopurine) and guanine (2-amino, 6-oxypurine), is made inside the cells of the body.
Under normal condition, uric acid is eliminated by the kidney through urination. However, a high uric acid level can occur when the kidneys don't eliminate uric acid efficiently. People with kidney deficiency are associated with high levels of uric acid if foods with high levels of purines are consumed in a large amount, including red meat, seafood, and mushroom.
Some researchers suggested that people who are obese, overweight with diabetes, long-term use of diuretics and excessive alcohol drinking are associated with the risk of high levels of uric acid in the blood.
Additionally, genetic mutation inherited from the parents such as Q141K polymorphism and CFTR ΔF508 certain medical conditions such as tumor lysis syndrome, hypothyroidism, and psoriasis are also some major risk factors to cause excessive levels of uric acid in the blood.
If you are currently taking long-term medications as maintenance therapy, to keep uric acid levels steady. Please make sure that you are aware of their side effects.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
According to the joint study led by the University of Nagasaki, green tea and its bioactive compounds Epigallo catechin-O-gallate (EGCG) may be considered as a putative curative drug for various diseases of gout, through its properties in reducing the vascular endothelial growth factor receptor 2 (VEGFR2) in response to vascular endothelial growth factor signal (VGFG) for the formation of gout through expression of levels of uric acid.
The study also emphasized that green tea with high levels of antioxidant and function in the stimulated production of natural antioxidant in the body may also be used to reduce symptoms of recurrently inflammatory arthritis and inflammatory arthritis such as gout, through inhibiting the oxidative stress in the induced production of inflammatory cytokines to facilitate symptoms of inflammation.
The above differentiation was supported by the study of the effect of EGCG on monosodium urate monohydrate (MSU)-induced inflammation and cryopyrin (NLRP3 inflammasome) activation in C57BL/6 mice received a subcutaneous injection or oral gavage of EGCG before the intraperitoneal injection of MSU.
Truly, the application green tea EGCG decreased expression of gouty arthritis caused by injection of MSU-induced neutrophil infiltration with a function to initiate inflammation in the acute phase of infection and IL-1β secretion, in response and resistance to pathogens, but can also exacerbate damage during chronic disease and acute tissue injury.
The injection of green EGCG also decreased MSU-triggered neutrophil cytosolic factor 1, in the activated inflammatory response to optimize healing and reduce injury to the body but the proteins have been found to cause severe damage to the infectious site and NLRP3 protein expression in initiated systematic inflammatory expression.
Moreover, the effect of green tea in protection against gout occurrence also limited pro-inflammatory mediator secretion interleukin 1 beta (IL1β), a mediator of inflammation, in response to acute phase infection, interleukin 6 (IL-6) produced by large amount at sites of acute and chronic inflammation, monocyte chemoattractant protein-1 in regulated monocytes, memory T cells, and dendritic cells to the sites of inflammation, and serum amyloid A, the serum was found to increase substantially in patients of chronic inflammatory disease, without limiting the function of the mediators in protect the infectious site against pathogens invasion.
More profoundly, the efficacy of green tea in reduced recurrent gout also extended to suppress NLRP3 inflammasome in stimulated caspase-1 in promoted secretion of others proinflammatory cytokines activation.
Dr. Jhang JJ, the lead author said, "EGCG treatment ameliorates MSU-induced inflammation, suggesting that EGCGexerts anti-inflammatory effect against MSU-induced acute gout attack."
Additionally, the University of Pretoria suggested that polyphenols extracted from green tea also exhibited an antioxidant effect in reducing the pronounce of oxidative stress by their antioxidant properties.
Catechin (C) (Ki = 303.95, uncompetitive), epicatechin (EC) (Ki = 20.48, mixed), epigallocatechin (EGC) (Ki = 10.66, mixed), epicatechin gallate (ECg) (Ki = 2.86, mixed) and epigallocatechin gallate (EGCg) (Ki = 0.76, competitive) were found to have similar efficacy as allopurinol (Ki = 0.30, mixed), the drug used to inhibit the levels of xanthine oxidase (XO) in gout patients, through reducing reactive oxygen species in the initiation of oxidative stress that facilitates the inflammatory symptoms.
Taken all together, green tea and its bioactive polyphenols may be considered as a functional food for reduced onset and combined with conventional medicine for the treatment of gout with no adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Multiple actions of EGCG, the main component of green tea].[Article in French] by L'Allemain G1.(PubMed)
(2) Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice by Jhang JJ1, Lu CC1, Yen GC2. (PubMed)
(3) Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis) by Aucamp J1, Gaspar A, Hara Y, Apostolides Z.(PubMed)
(4) Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication by Jhang JJ1, Lin JH1, Yen GC1.(PubMed)
(5) Association and interaction effect between VEGF receptor-2 (VEGFR-2) gene polymorphisms and dietary pattern on blood uric acid in Malays and Indians by Roseline YW1, Shidoji Y1, Hon WM2, Masaki M1. (PubMed)
Gout is a condition of recurrently inflammatory arthritis characterized by a red, tender, hot, and swollen joint caused by overexpression of purine in the body.
Gout is caused by an excess of uric acid in the blood, or hyperuricemia. Uric acid is a by-product that is produced during the digestive process in the breaking down of chemical ingredients purines.
Purines are natural nitrogen-containing compounds found in the cell DNA and RNA, including adenine (6-aminopurine) and guanine (2-amino, 6-oxypurine), is made inside the cells of the body.
Under normal condition, uric acid is eliminated by the kidney through urination. However, a high uric acid level can occur when the kidneys don't eliminate uric acid efficiently. People with kidney deficiency are associated with high levels of uric acid if foods with high levels of purines are consumed in a large amount, including red meat, seafood, and mushroom.
Some researchers suggested that people who are obese, overweight with diabetes, long-term use of diuretics and excessive alcohol drinking are associated with the risk of high levels of uric acid in the blood.
Additionally, genetic mutation inherited from the parents such as Q141K polymorphism and CFTR ΔF508 certain medical conditions such as tumor lysis syndrome, hypothyroidism, and psoriasis are also some major risk factors to cause excessive levels of uric acid in the blood.
If you are currently taking long-term medications as maintenance therapy, to keep uric acid levels steady. Please make sure that you are aware of their side effects.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
According to the joint study led by the University of Nagasaki, green tea and its bioactive compounds Epigallo catechin-O-gallate (EGCG) may be considered as a putative curative drug for various diseases of gout, through its properties in reducing the vascular endothelial growth factor receptor 2 (VEGFR2) in response to vascular endothelial growth factor signal (VGFG) for the formation of gout through expression of levels of uric acid.
The study also emphasized that green tea with high levels of antioxidant and function in the stimulated production of natural antioxidant in the body may also be used to reduce symptoms of recurrently inflammatory arthritis and inflammatory arthritis such as gout, through inhibiting the oxidative stress in the induced production of inflammatory cytokines to facilitate symptoms of inflammation.
The above differentiation was supported by the study of the effect of EGCG on monosodium urate monohydrate (MSU)-induced inflammation and cryopyrin (NLRP3 inflammasome) activation in C57BL/6 mice received a subcutaneous injection or oral gavage of EGCG before the intraperitoneal injection of MSU.
Truly, the application green tea EGCG decreased expression of gouty arthritis caused by injection of MSU-induced neutrophil infiltration with a function to initiate inflammation in the acute phase of infection and IL-1β secretion, in response and resistance to pathogens, but can also exacerbate damage during chronic disease and acute tissue injury.
The injection of green EGCG also decreased MSU-triggered neutrophil cytosolic factor 1, in the activated inflammatory response to optimize healing and reduce injury to the body but the proteins have been found to cause severe damage to the infectious site and NLRP3 protein expression in initiated systematic inflammatory expression.
Moreover, the effect of green tea in protection against gout occurrence also limited pro-inflammatory mediator secretion interleukin 1 beta (IL1β), a mediator of inflammation, in response to acute phase infection, interleukin 6 (IL-6) produced by large amount at sites of acute and chronic inflammation, monocyte chemoattractant protein-1 in regulated monocytes, memory T cells, and dendritic cells to the sites of inflammation, and serum amyloid A, the serum was found to increase substantially in patients of chronic inflammatory disease, without limiting the function of the mediators in protect the infectious site against pathogens invasion.
More profoundly, the efficacy of green tea in reduced recurrent gout also extended to suppress NLRP3 inflammasome in stimulated caspase-1 in promoted secretion of others proinflammatory cytokines activation.
Dr. Jhang JJ, the lead author said, "EGCG treatment ameliorates MSU-induced inflammation, suggesting that EGCGexerts anti-inflammatory effect against MSU-induced acute gout attack."
Additionally, the University of Pretoria suggested that polyphenols extracted from green tea also exhibited an antioxidant effect in reducing the pronounce of oxidative stress by their antioxidant properties.
Catechin (C) (Ki = 303.95, uncompetitive), epicatechin (EC) (Ki = 20.48, mixed), epigallocatechin (EGC) (Ki = 10.66, mixed), epicatechin gallate (ECg) (Ki = 2.86, mixed) and epigallocatechin gallate (EGCg) (Ki = 0.76, competitive) were found to have similar efficacy as allopurinol (Ki = 0.30, mixed), the drug used to inhibit the levels of xanthine oxidase (XO) in gout patients, through reducing reactive oxygen species in the initiation of oxidative stress that facilitates the inflammatory symptoms.
Taken all together, green tea and its bioactive polyphenols may be considered as a functional food for reduced onset and combined with conventional medicine for the treatment of gout with no adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Multiple actions of EGCG, the main component of green tea].[Article in French] by L'Allemain G1.(PubMed)
(2) Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice by Jhang JJ1, Lu CC1, Yen GC2. (PubMed)
(3) Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis) by Aucamp J1, Gaspar A, Hara Y, Apostolides Z.(PubMed)
(4) Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication by Jhang JJ1, Lin JH1, Yen GC1.(PubMed)
(5) Association and interaction effect between VEGF receptor-2 (VEGFR-2) gene polymorphisms and dietary pattern on blood uric acid in Malays and Indians by Roseline YW1, Shidoji Y1, Hon WM2, Masaki M1. (PubMed)
Subscribe to:
Posts (Atom)