Scientists may have found a whole food for the treatment and improvement of the quality of life of post-stroke patients and without inducing any side effects, according to studies.
Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.
In other words, a stroke can either be results of a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).
A mini-stroke is a temporary disruption of blood flow to the brain that only causes some disruption to the brain with inducing permanent damage.
Depending on the parts of the neuron being damage, patients may experience different symptoms. However, most common symptoms of stroke include paralysis or numbness of the face, arm or leg, problems in vision, speaking, walking and persistent headache.
Certain medical conditions such as diabetes. heart diseases, long-term use of tobacco, the increase in age, ethnicity are some prevalent risk factors of stroke.
Out of many risk factors, people who have hypertension, particularly untreated hypertension and follow the Western diet are at increased risk of the onset of stroke, according to epidemiological studies.
In examining the post-stroke patients, a poor diet pattern with a high in saturated and trans fat, red meat and processed foods have been found in the high percentage, compared to the traditional diet.
Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in risk of stoke wrote, " adherence to the improvements in nutrition and diet can reduce the incidence of stroke. Higher antioxidant, vitamins, potassium, calcium, vegetables, fruits, whole grain intake, and adherence to the Mediterranean diet or DASH diet can lower stroke incidence".
The statement clearly suggested that a healthy diet rich in fruits and vegetable and whole grain and low in red meat, saturated fat and trans fat, and processed food is the best for prevention and stroke.
Celery is a species of Apium graveolens, belonging to the family Apiaceae. The plant is cultivated all around the globe as a vegetable.
Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
On finding a natural ingredient with no side effect for the treatment of patients with acute ischemic stroke, researchers evaluated the Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, efficacy in animal models of stroke.
The randomized, double-blind, double-dummy trial included 573 patients within 48 hours of onset of ischemic stroke in China.
Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14-day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin.
After taking into account co and confounder, among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP demonstrated a significant improvement than 14-day treatment with ozagrel as measured by the modified Rankin scale (mRS).
Where Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.
According to Barthel index at day 90, there is no significant difference among the three groups. The rate of adverse events was similar among the three groups.
Furthermore, on a stroke induced by the middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY), researchers compared the results of the pre-treatment of NBP administered to SHR and WKY daily for two months prior to MCAO and post-treatment of NBP given daily for seven consecutive days after MCAO.
In SHR, NBP pre- and post-treatment significantly lowered neurological deficit scores, reduced infarct volume, and minimized pathological changes in the penumbra area compared to oil-vehicle treated controls.
In other words, NBP pre- and post-treatment reduced the potential damage penumbra area through its neuroprotective activity.
However, in WKY, these beneficial effects were observed only in the post-treatment group, compared to SHR.
Dr. Zhang L, at the end of the experiment, wrote, "NBP could exert both preventive and therapeutic effects on ischemic stroke in SHR, but only exerted a therapeutic effect in WKY".
Taken altogether, Chinese celery processed high amounts of Dl-3-n-butylphthalide (NBP) may be considered a functional food for the post-treatment of patients with stroke.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial and Cui LY1, Zhu YC, Gao S, Wang JM, Peng B, Ni J, Zhou LX, He J, Ma XQ.(PubMed)
(2) DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment by Zhang L1, Yu WH, Wang YX, Wang C, Zhao F, Qi W, Chan WM, Huang Y, Wai MS, Dong J, Yew DT.(PubMed)
(3) Stroke and Nutrition: A Review of Studies by Mehdi Foroughi,2 Mohsen Akhavanzanjani,2 Zahra Maghsoudi,2 Reza Ghiasvand,1,2Fariborz Khorvash,3 and Gholamreza Askari. (PMC)
Sunday, March 10, 2019
Honey, The Functional Food Which Kills Bladder Cancer Cells in Vivo and Vitro, Scientists Find
Scientists may have found a natural food source which processes the potential for the treatment of bladder cancer with no side effects, some studies suggested.
Bladder cancer is a medical condition characterized by irregular cell growth in the bladder.
Most cases of the primary bladder cancer start in the cell on the surface of the inner lining of the bladder tissue.
At the early stage, most bladder cancers do not cause any symptoms. However, at the advanced stage, the prostate can cause a distance metastasis to infect other healthy tissue and organ through the circulation of blood and fluids.
At this advanced stage, patients may experience symptoms of pain and blood in the urine caused by the proliferative tumor suppressing the nerve cells and breaking the blood vessels in the bladder.
Researchers do not the exact causes of bladder cancer. But certain risk factors such as tobacco use, aging, gender, ethnicity, long-term bladder condition and exposure to chemicals are at a higher risk of the onset of the disease.
The warning from the FDA also suggested the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer.
In fact, most people with some of the above risk factors have never developed bladder cancer even they are associated with the increased risk all their life.
Although most scientists agree that tobacco use is the major cause of bladder cancer, genetic preposition, according to the epidemiological studies is also the substantial risk of bladder cancer, such as the genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder.
Sadly, People with gene mutation are at the 70 % higher risk of bladder cancer compared to those do not.
Dr. Zhang X, the lead author in the study "Bladder Cancer and Genetic Mutations" specified, "The changes in the genes of human chromosome 9 are usually responsible for tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer". and "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".
And, "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".
Honey, is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient for the prevention and treatment of bladder cancer without inducing any side effects, researchers at the University of Tsukuba conducted an experiment to examine the antitumor effect of bee honey against bladder cancer in vitro and in vivo.
The study included three human bladder cancer cell lines (T24, 253J, and RT4) and one murine bladder cancer cell line (MBT-2).
In vitro studies application of honey significantly inhibited the proliferation of T24 and MBT-2 cell lines by 1-25% honey and of RT4 and 253J cell lines by 6-25% observed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.
Bromodeoxyuridine (BrdU) labeling index, an indicator of early tumor response to the injection of honey was lower in vitro.
FCM showed lower S-phase fraction, as well as the absence of aneuploidy compared with control cells.
Flowcytometry (FCM). in the measurement of can cancer cells physical and chemical characteristics showed lower S-phase fraction and the absence of aneuploidy compared with control cells, an indication of inhibitory cancer cells by the application of honey.
Furthermore, In the in vivo, intralesional injection of 6 and 12% honey, as well as oral ingestion of honey, significantly inhibited tumor growth.
These results suggested that bee honey processes a significant activity for inhibiting the growth of T24, RT4, 253J, and MBT-2 bladder cancer cell lines in vitro.
And, honey is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models.
Dr, Swellam T, the lead author after taking into account co and confounders wrote, " Our results are promising,,,,,, the mechanisms of the antitumor activity of honey".
Taken altogether, honey may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bladder cancer.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-bladder cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies by Swellam T1, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H. (PubMed)
(2) Bladder Cancer and Genetic Mutations by Zhang X1, Zhang Y. (PubMed)
Saturday, March 9, 2019
Herbal Aloe Vera Juice, the Potent Mouth Wash for Treatment of Oral Mucositis Caused by Chemo and Radiation Therapy in Patients with Head and Neck Cancer
Aloe vera may have a potential effect in reducing the oral mucositis in patients with head and neck cancer, some scientists suggested.
Head and neck cancer is a class of cancers that start in the mouth, throat, larynx, sinuses, or salivary glands.
At the early stage, cells on the surface of the inner lining associated with head and neck start to grow irregularly and disorderly.
However, at the advanced stage, as cancer has penetrated into the deeper layers, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.
In some cases at the advanced stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.
Most common head and neck cancer metastases are secondary skin cancer.
Oral mucositis is one of the common side effects in cancer patients who are under chemo and radiation treatment, leading to symptoms of pain, nutritional problems as a result of an inability to eat, and increased risk of infection due to open sores in the mucosa.
The symptom has been found to reduce the quality of life of cancer patients.
According to The Oral Cancer Foundation, patients experience the side effect of oral mucositis after 5 to 10 days of chemotherapy. Normally, the side effect will disappear itself in short few weeks, depending on the types of medicine, doses, and duration of the treatment.
Dr. Begonya Chaveli-López, the lead author in the study "Treatment of oral mucositis due to chemotherapy" wrote, "Very few interventions of confirmed efficacy are available for the management of oral mucositis due to chemotherapy. However, according to the reviewed literature, the use of palifermin, cryotherapy and low power laser offer benefits, reducing the incidence and severity of oral mucositis".
On finding a natural and effective ingredient for the treatment of oral mucositis with no side effects, researchers examined the topical Aloe vera, a widely used for mild sunburn, frostbites, and scalding burns for its effect on mucositis.
Aloe gel showed the beneficial effects of wound healing, mucous membrane protection, and treatment of oral ulcers.
Application of Aloe gel also enhanced the anti-inflammatory, immunomodulation, antifungal, scavenging free radicals, increasing collagen formation and inhibiting collagenase, epidemiological studies suggested.
Oral Aloe vera mouthwash demonstrated significant prevention of radiation-induced mucositis by its wound healing and anti-inflammatory mechanism.
The herbal mouthwash also reduced oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties.
These efficacies indicated that Aloe vera mouthwash may be considered an alternative potential for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers.
Futhermore, in the finding the most effective agent for treatment of oral mucositis, the Haji Mirza Mohammad conducted a triple-blind, randomized controlled trial in the comparison of the Aloe vera mouthwash with a benzydamine mouthwash in the alleviation of radiation-induced mucositis in head and neck cancer patients.
The trial included 26 eligible head and neck cancer patients who were to receive conventional radiation therapy at the radiation oncology department were randomized to receive an Aloe vera mouthwash or a benzydamine mouthwash.
No difference in the distribution of mucositis severity between the two groups, at the baseline.
The mean interval between radiation therapy and the onset of mucositis was similar for both groups.
The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days).
According to the comparison test researchers suggested that the Aloe vera mouthwash could be an alternative agent in the treatment of radiation-induced mucositis in patients with head and neck cancer due to its exertion of the similar effects as of those of beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis with no side effects.
Taken altogether, herbal Aloe vera juice may be considered a functional juice for the treatment of the side effect of oral mucositis caused by chemo and radiation therapy in patients with head and neck cancer
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. by Ahmadi A.(PubMed)
(3) Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial by Sahebjamee M, Mansourian A, Hajimirzamohammad M, Zadeh MT, Bekhradi R, Kazemian A, Manifar S, Ashnagar S, Doroudgar K.(PubMed)
Head and neck cancer is a class of cancers that start in the mouth, throat, larynx, sinuses, or salivary glands.
At the early stage, cells on the surface of the inner lining associated with head and neck start to grow irregularly and disorderly.
However, at the advanced stage, as cancer has penetrated into the deeper layers, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.
In some cases at the advanced stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.
Most common head and neck cancer metastases are secondary skin cancer.
Oral mucositis is one of the common side effects in cancer patients who are under chemo and radiation treatment, leading to symptoms of pain, nutritional problems as a result of an inability to eat, and increased risk of infection due to open sores in the mucosa.
The symptom has been found to reduce the quality of life of cancer patients.
According to The Oral Cancer Foundation, patients experience the side effect of oral mucositis after 5 to 10 days of chemotherapy. Normally, the side effect will disappear itself in short few weeks, depending on the types of medicine, doses, and duration of the treatment.
Dr. Begonya Chaveli-López, the lead author in the study "Treatment of oral mucositis due to chemotherapy" wrote, "Very few interventions of confirmed efficacy are available for the management of oral mucositis due to chemotherapy. However, according to the reviewed literature, the use of palifermin, cryotherapy and low power laser offer benefits, reducing the incidence and severity of oral mucositis".
On finding a natural and effective ingredient for the treatment of oral mucositis with no side effects, researchers examined the topical Aloe vera, a widely used for mild sunburn, frostbites, and scalding burns for its effect on mucositis.
Aloe gel showed the beneficial effects of wound healing, mucous membrane protection, and treatment of oral ulcers.
Application of Aloe gel also enhanced the anti-inflammatory, immunomodulation, antifungal, scavenging free radicals, increasing collagen formation and inhibiting collagenase, epidemiological studies suggested.
Oral Aloe vera mouthwash demonstrated significant prevention of radiation-induced mucositis by its wound healing and anti-inflammatory mechanism.
The herbal mouthwash also reduced oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties.
These efficacies indicated that Aloe vera mouthwash may be considered an alternative potential for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers.
Futhermore, in the finding the most effective agent for treatment of oral mucositis, the Haji Mirza Mohammad conducted a triple-blind, randomized controlled trial in the comparison of the Aloe vera mouthwash with a benzydamine mouthwash in the alleviation of radiation-induced mucositis in head and neck cancer patients.
The trial included 26 eligible head and neck cancer patients who were to receive conventional radiation therapy at the radiation oncology department were randomized to receive an Aloe vera mouthwash or a benzydamine mouthwash.
No difference in the distribution of mucositis severity between the two groups, at the baseline.
The mean interval between radiation therapy and the onset of mucositis was similar for both groups.
The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days).
According to the comparison test researchers suggested that the Aloe vera mouthwash could be an alternative agent in the treatment of radiation-induced mucositis in patients with head and neck cancer due to its exertion of the similar effects as of those of beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis with no side effects.
Taken altogether, herbal Aloe vera juice may be considered a functional juice for the treatment of the side effect of oral mucositis caused by chemo and radiation therapy in patients with head and neck cancer
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. by Ahmadi A.(PubMed)
(3) Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial by Sahebjamee M, Mansourian A, Hajimirzamohammad M, Zadeh MT, Bekhradi R, Kazemian A, Manifar S, Ashnagar S, Doroudgar K.(PubMed)
Ginger, The Spice Which Protects Our Body Against Inflammatory Diseases
Scientists may have found a pungent and kitchen spices which process a potential effect on the prevention and treatment of chronic inflammatory diseases without inducing any side effects.
Inflammation is a natural reaction of the immune system whose function is to protect our body against the invasion of the foreign stimuli and pathogens.
In the acute phase of tissue damage or injury, the white blood cells responsible for the first line of defense activate the production of the inflammatory cytokines to the site of infection with an aim to kill off the invasive agents.
However, in most cases, overproduction of inflammatory cytokines can damage the nearby cells and lead to improper healing with the formation of scars.
Chronic inflammation is an inflammation that lasts more than 3 months. The development and progression of chronic inflammatory diseases are the results of the immune system which can not kill off the invasive pathogens in the acute phase of infection or immune system mistakenly attacks the body tissue, leading to the persistently the low-grade inflammation.
In the further analysis of the evolution of physiological supersystems involved chronic inflammatory disease, Dr. Rainer H. Straub, the lead author said, "It is predicted that genes that protect energy stores are positively selected (as immune memory). This could explain why energy-demanding inflammatory episodes like infectious diseases must be terminated within 3–8 weeks to be adaptive, and otherwise become maladaptive:
These results suggested that the genes and networks used evolved during physiological supersystems, fitness consequences and during different life-history stages are positively selected if they serve acute, highly energy-consuming inflammation.
In other words, the immune system becomes maladaptive, if inflammation does not terminate within eight weeks of infection.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The kitchen has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding a natural ingredient for the treatment of inflammation without inducing any adverse effects, a joint study led by the CHA University, Seongnam was conducted to examine the molecular mechanism of 6-gingerol on adipocyte-mediated systemic inflammation in vitro and in high-fat-diet-induced obese zebrafish.
Injection of 6-gingerol exerted a significantly increased the production of anti-inflammatory cytokine interleukin-10 and decreased the expression of proinflammatory cytokines, TNFα, monocyte chemotactic protein-1, interleukin-1β, and interleukin-6.
In the RAW 264.7 macrophages, 6-gingerol inhibited the protein expression of proinflammatory factors TNFα and monocyte chemotactic protein-1, a small cytokine that belongs to the CC chemokine family.
6-Gingerol decreased c-JUN N-terminal kinase and I kappa B kinase beta which plays an important role in the inhibition of nuclear factor kappa-B kinase activated by multiple stimuli such as inflammatory cytokines
Where JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes including inflammation.
6-gingerol also decreased the expression of inducible nitric oxide synthase in the stimulation of the expression of inflammation.
Dr. Choi J, the lead scientists wrote in the final report, " 6-gingerol suppresses inflammation through the regulation of the c-JUN N-terminal kinase-I kappa B kinase beta and its downstream targets".
Furthermore, the investigation of the effects of 6-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone) in experimental models that HepG2 cells were exposed to 500 µmol/l oleic acid (OA) for 24 h and preincubated for an additional 24 h with 6-gingerol (25, 50 or 100 µmol/l). 6-Gingerol (100 µmol/l) inhibited OA-induced triglyceride and inflammatory marker accumulation in HepG2 cells of non-alcoholic steatohepatitis also suggested that
* Daily application of 6ginger for 8 weeks while maintained on HFD. 6-Gingerol (100 mg/kg/day) alleviated liver steatosis, inflammation, and reversed
* [6]-gingerol also attenuated the expression of inflammatory cytokine genes and nuclear transcription factor-κB (NF-κB) increased in the HFD group.
The results strongly indicated 6-Gingerol attenuates HFD-induced steatohepatitis by downregulating NF-κB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.
More interestingly, in the study includes five groups of rats containing 14 rats/group received corn oil (control), CPF (5 mg/kg), 6-GRF (100 mg/kg), CPF (5 mg/kg) + 6-GRF (50 mg/kg) and CPF (5 mg/kg) + 6-GRF (100 mg/kg) through gavage once per day for 35 days respectively, researchers showed that
* Before 6-gingerol application CPF-induced rats showed an increase in oxidative stress ((hydrogen peroxide (H2O2) and malondialdehyde (MDA)), inflammatory (myeloperoxidase (MPO), nitric oxide (NO) nitric oxide (NO) and tumor necrosis factor-α (TNF- α)), and apoptotic (caspase-3) markers.
* Injection of 6-gingerol attenuated all factors in the CPF induced rats.
* 6-GRF reduced the inflammatory expression through improving the activities of antioxidant enzymes catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) as well as glutathione (GSH) level in the brain, ovary, and uterus of rats exposed to CPF.
Dr. Abolaji AO the lead author said, " the protective effects of 6-GRF on CPF-induced toxicity in the brain and reproductive organs of rats may be due to it's potent antioxidative, anti-inflammatory and antiapoptotic properties".
Where Chlorpyrifos (CPF) is an organophosphorus pesticide widely used in agricultural applications and household environments.
Taken all together, ginger processed abundantly 6-gingerol may be considered a functional kitchen spice for the prevention and treatment of inflammation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 6-Gingerol Suppresses Adipocyte-Derived Mediators of Inflammation In Vitro and in High-Fat Diet-Induced Obese Zebra Fish by Choi J1, Kim KJ1, Kim BH2, Koh EJ1, Seo MJ1, Lee BY. (PubMed)
(2) [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis by Tzeng TF1, Liou SS1, Chang CJ1, Liu IM. (PubMed)
(3) Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary, and uterus of rats by Abolaji AO1, Ojo M2, Afolabi TT2, Arowoogun MD2, Nwawolor D2, Farombi EO. (PubMed)
Friday, March 8, 2019
Manuka Honey (MH) and Tualang Honey (TH), the Potential Natural Antibiotics Alternative with No Side Effects
Scientists may have found natural alternative antibiotics for the treatment of diseases caused by a bacterial infection, some studies found.
Infection is a medical condition caused by bacteria multiplication after entering the body.
Most bacteria were killed off by the white blood cells of the first line of defense of the immune system before they can enter the body.
In this stage, the immune systematic response stimulates the production of proteins associated with the production of coagulation to seal the wound and damage and pro-inflammatory cytokines to destroy the invaded bacteria, leading to symptoms of fever, skin redness in the infected area.
However, if they enter the body successfully, they can initiate infection through the stage of incubation where bacterial multiplying in the specific tissues and organs, leading to the colonization and in facilitating diseases development.
Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.
Some bacterial pathogens can establish life-long chronic infections in the host by persistent establishment after an acute infection period.
Dr. Young D, the lead scientist, at the Technology and Medicine, said," Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection"
" Persistent bacterial infection may involve occupation of a particular tissue type or organ or modification of the intracellular environment within eukaryotic cells".
"Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors".
These result firmly suggested that if you have a weakened immune system you are at a higher risk to the onset of chronic bacterial infection.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding natural sources as a new antibiotic with no side effects, researchers examine the Manuka honey (MH) antibacterial effect in bioactive wound dressings.
Epidemiological studies suggested that MH provides unique antibacterial activity compared to conventional kinds of honey, due to its constituents, methylglyoxal (MGO).
In the evaluation of the antibacterial activity of both MH and MGO (at equivalent MGO concentrations) when applied as a physical coating to a nonwoven fabric wound dressing, researchers found that* Application of concentrations of 0.0054 mg cm-2 of MGO in the form of MH and MGO is sufficient to achieve a 100 colony forming unit % bacteria reduction against gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumonia.
* However, a 3- to 20-fold increase in MGO concentration (0.0170-0.1 mg cm-2) was required to facilitate a good antibacterial effect.
These results suggested that Manuka honey antibacterial activity processed a linearly and MGO concentration-dependent manner.
Dr. Bulman SEL, the lead scientist said, "The results presented in this study, therefore, demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries".
Additionally, in the investigation of the traditional use of Tualang honey (TH) for the treatment of bacterial infection against various microorganisms, including those from burn-related diagnoses, compared the anti antibacterial activity of Aquacel-Tualang honey, Aquacel-Manuka honey, Aquacel-Ag, and Aquacel- plain dressings against bacteria isolated from patients.
Four types of Gram-negative bacteria, namely Enterobacter cloacae, Klebsiella pneumoniae, Pseudomonas spp. and Acinetobacter spp., and three Gram-positive bacteria, namely Staphylococcus aureus, coagulase-negative Staphylococcus aureus (CONS) and Streptococcus spp. were included in the study.
All tested agents showed a significant effect inhibiting the total bacterial count on day 6 and onwards.
Aquacel-Ag and Aquacel-Manuka honey dressings gave a better zone of inhibition for Gram-positive bacteria compared to Aquacel-Tualang honey dressing.
The comparable results were also found in the Aquacel-Manuka honey and Aquacel-Tualang honey dressing against Gram-negative bacteria.
Researchers after taking into account co and confounders suggested that Tualang honey has a bactericidal as well as bacteriostatic effect and is easier to apply and less sticky compared to Manuka honey.
Taken altogether, there is no doubt that Manuka honey (MH) and Tualang honey (TH) may be considered a functional remedy for the prevention and treatment of bacterial infection. However, before they can be used as antibiotics similar to those of conventional medicine, a larger and multicenter human study is necessary to reconfirm the viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal by Bulman SEL1, Tronci G2, Goswami P3, Carr C4, Russell SJ5.(PubMed)
(2) Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study by Nasir NA1, Halim AS, Singh KK, Dorai AA, Haneef MN.(PubMed)
(3) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey by Tan HT1, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(PubMed)
(4) Chronic bacterial infections: living with unwanted guests by Young D1, Hussell T, Dougan G.(PubMed)
Infection is a medical condition caused by bacteria multiplication after entering the body.
Most bacteria were killed off by the white blood cells of the first line of defense of the immune system before they can enter the body.
In this stage, the immune systematic response stimulates the production of proteins associated with the production of coagulation to seal the wound and damage and pro-inflammatory cytokines to destroy the invaded bacteria, leading to symptoms of fever, skin redness in the infected area.
However, if they enter the body successfully, they can initiate infection through the stage of incubation where bacterial multiplying in the specific tissues and organs, leading to the colonization and in facilitating diseases development.
Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.
Some bacterial pathogens can establish life-long chronic infections in the host by persistent establishment after an acute infection period.
Dr. Young D, the lead scientist, at the Technology and Medicine, said," Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection"
" Persistent bacterial infection may involve occupation of a particular tissue type or organ or modification of the intracellular environment within eukaryotic cells".
"Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors".
These result firmly suggested that if you have a weakened immune system you are at a higher risk to the onset of chronic bacterial infection.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding natural sources as a new antibiotic with no side effects, researchers examine the Manuka honey (MH) antibacterial effect in bioactive wound dressings.
Epidemiological studies suggested that MH provides unique antibacterial activity compared to conventional kinds of honey, due to its constituents, methylglyoxal (MGO).
In the evaluation of the antibacterial activity of both MH and MGO (at equivalent MGO concentrations) when applied as a physical coating to a nonwoven fabric wound dressing, researchers found that* Application of concentrations of 0.0054 mg cm-2 of MGO in the form of MH and MGO is sufficient to achieve a 100 colony forming unit % bacteria reduction against gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumonia.
* However, a 3- to 20-fold increase in MGO concentration (0.0170-0.1 mg cm-2) was required to facilitate a good antibacterial effect.
These results suggested that Manuka honey antibacterial activity processed a linearly and MGO concentration-dependent manner.
Dr. Bulman SEL, the lead scientist said, "The results presented in this study, therefore, demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries".
Additionally, in the investigation of the traditional use of Tualang honey (TH) for the treatment of bacterial infection against various microorganisms, including those from burn-related diagnoses, compared the anti antibacterial activity of Aquacel-Tualang honey, Aquacel-Manuka honey, Aquacel-Ag, and Aquacel- plain dressings against bacteria isolated from patients.
Four types of Gram-negative bacteria, namely Enterobacter cloacae, Klebsiella pneumoniae, Pseudomonas spp. and Acinetobacter spp., and three Gram-positive bacteria, namely Staphylococcus aureus, coagulase-negative Staphylococcus aureus (CONS) and Streptococcus spp. were included in the study.
All tested agents showed a significant effect inhibiting the total bacterial count on day 6 and onwards.
Aquacel-Ag and Aquacel-Manuka honey dressings gave a better zone of inhibition for Gram-positive bacteria compared to Aquacel-Tualang honey dressing.
The comparable results were also found in the Aquacel-Manuka honey and Aquacel-Tualang honey dressing against Gram-negative bacteria.
Researchers after taking into account co and confounders suggested that Tualang honey has a bactericidal as well as bacteriostatic effect and is easier to apply and less sticky compared to Manuka honey.
Taken altogether, there is no doubt that Manuka honey (MH) and Tualang honey (TH) may be considered a functional remedy for the prevention and treatment of bacterial infection. However, before they can be used as antibiotics similar to those of conventional medicine, a larger and multicenter human study is necessary to reconfirm the viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal by Bulman SEL1, Tronci G2, Goswami P3, Carr C4, Russell SJ5.(PubMed)
(2) Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study by Nasir NA1, Halim AS, Singh KK, Dorai AA, Haneef MN.(PubMed)
(3) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey by Tan HT1, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(PubMed)
(4) Chronic bacterial infections: living with unwanted guests by Young D1, Hussell T, Dougan G.(PubMed)
Herbal Chamomile Kills Cancer Cells Before They Can Spread
Scientists may have found a herbal plant which processes a strong potential for the treatment of cancer without inducing any side effects, some studies suggested.
Cancers are a class of diseases associated with the irregular and disorder cell growth in the tissue or organs in the body due to the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the tissue and organ tissue. However, as the cancer proliferation, they can penetrate into the deeper layers of the tissue or organ.
At the advanced stage, the primary cancer site can travel a distance away from the primary site to infect other healthy tissue and organ through fluids and blood circulation.
The exact causes of cancer are unknown. According to the epidemiological studies, the most common risk factors associated with the early onset of the diseases are smoking and tobacco, diet, physical inactivity, long-term exposure to the.sun and radiation and a certain type of virus and bacteria.
Out of all the risk factors that increase the cancer risk, physical activity is one of the factors which has not been under intensified study by the science community.
In the study to examine the accumulate on the benefits of physical activity in relation to cancer risk, progression, and mortality, researchers suggested
* Sedentary behavior may independently affect cancer risk
* The associations with physical activity, including cancer risk factors existed for precancerous lesions.
Although researchers know that physical activity is an important issue associated with the onset of cancer, they do not know the subgroup risk defined by body size, age or sex and tumors subgroups defined by the organ location, receptor status, or molecular subtype.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In the reaffirming the traditional use of chamomile for the treatment of chronic ailments, researchers examine the anticancer properties of aqueous and methanolic extracts of chamomile against various human cancer cell lines.
Chamomile extracts a significant decrease in cell viability in various human cancer cell lines without inducing herm to the healthy cells.
Injection of the herbal extract causes the apoptosis of cancer cells, causing herm to the normal cells.
The anti cancers effect of chamomile extract was attributed to the bioactive compound apigenin 7-O-glucoside, the major constituent of chamomile; some minor glycoside components.
These results reconfirm the use of chamomile extract in the treatment of cancers in traditional medicine.
Furthermore, the study to compare the anticancer activity of phenolic profile of six herbal infusions namely Cretan marjoram, pink savory, oregano, mountain tea, pennyroyal and chamomile by LCDAD-MS and by GC-MS, suggested
* All herbal infusions exhibit antiradical activity correlated positively with total phenolic content
* All infusions exhibit the potential to inhibit cell proliferation and to reduce IL-8 levels in HT29 colon and PC3 prostate cancer cells.
* The efficacy of all herbal medicines in inhibition of cancer cell line was attributed to the activation of the proteins associated with the cell death programming and production of the inflammatory cytokine.
Interestingly, in the comparison the cancer property of 20 essential oil from herbal plants, Dr. Mitoshi M, the lead scientists indicated, EOs from the herbal plants showed patterns of inhibition of DNA replicative property, similar to their cancer cell growth inhibitory activity, and their inhibitory activity and EOs from chamomile (Matricaria chamomilla L.) showed significant effects on both cancer cell growth and mast cell degranulation.
Taken altogether, chamomile extract, essential oil may be used with no side effects for the prevention and combined with the primary medicine for the treatment of cancers.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells.
Srivastava JK1, Gupta S.(PubMed)
(2) Herbal infusions; their phenolic profile, antioxidant and anti-inflammatory effects in HT29 and PC3 cells by Kogiannou DA1, Kalogeropoulos N, Kefalas P, Polissiou MG, Kaliora AC. (PubMed)
(3) Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities by Mitoshi M1, Kuriyama I, Nakayama H, Miyazato H, Sugimoto K, Kobayashi Y, Jippo T, Kanazawa K, Yoshida H, Mizushina Y. (PubMed)
(4) Physical Activity and Cancer by Jessica Clague and Leslie Bernstein. (PMC)
Cancers are a class of diseases associated with the irregular and disorder cell growth in the tissue or organs in the body due to the alternation of cell DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the tissue and organ tissue. However, as the cancer proliferation, they can penetrate into the deeper layers of the tissue or organ.
At the advanced stage, the primary cancer site can travel a distance away from the primary site to infect other healthy tissue and organ through fluids and blood circulation.
The exact causes of cancer are unknown. According to the epidemiological studies, the most common risk factors associated with the early onset of the diseases are smoking and tobacco, diet, physical inactivity, long-term exposure to the.sun and radiation and a certain type of virus and bacteria.
Out of all the risk factors that increase the cancer risk, physical activity is one of the factors which has not been under intensified study by the science community.
In the study to examine the accumulate on the benefits of physical activity in relation to cancer risk, progression, and mortality, researchers suggested
* Sedentary behavior may independently affect cancer risk
* The associations with physical activity, including cancer risk factors existed for precancerous lesions.
Although researchers know that physical activity is an important issue associated with the onset of cancer, they do not know the subgroup risk defined by body size, age or sex and tumors subgroups defined by the organ location, receptor status, or molecular subtype.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In the reaffirming the traditional use of chamomile for the treatment of chronic ailments, researchers examine the anticancer properties of aqueous and methanolic extracts of chamomile against various human cancer cell lines.
Chamomile extracts a significant decrease in cell viability in various human cancer cell lines without inducing herm to the healthy cells.
Injection of the herbal extract causes the apoptosis of cancer cells, causing herm to the normal cells.
The anti cancers effect of chamomile extract was attributed to the bioactive compound apigenin 7-O-glucoside, the major constituent of chamomile; some minor glycoside components.
These results reconfirm the use of chamomile extract in the treatment of cancers in traditional medicine.
Furthermore, the study to compare the anticancer activity of phenolic profile of six herbal infusions namely Cretan marjoram, pink savory, oregano, mountain tea, pennyroyal and chamomile by LCDAD-MS and by GC-MS, suggested
* All herbal infusions exhibit antiradical activity correlated positively with total phenolic content
* All infusions exhibit the potential to inhibit cell proliferation and to reduce IL-8 levels in HT29 colon and PC3 prostate cancer cells.
* The efficacy of all herbal medicines in inhibition of cancer cell line was attributed to the activation of the proteins associated with the cell death programming and production of the inflammatory cytokine.
Interestingly, in the comparison the cancer property of 20 essential oil from herbal plants, Dr. Mitoshi M, the lead scientists indicated, EOs from the herbal plants showed patterns of inhibition of DNA replicative property, similar to their cancer cell growth inhibitory activity, and their inhibitory activity and EOs from chamomile (Matricaria chamomilla L.) showed significant effects on both cancer cell growth and mast cell degranulation.
Taken altogether, chamomile extract, essential oil may be used with no side effects for the prevention and combined with the primary medicine for the treatment of cancers.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells.
Srivastava JK1, Gupta S.(PubMed)
(2) Herbal infusions; their phenolic profile, antioxidant and anti-inflammatory effects in HT29 and PC3 cells by Kogiannou DA1, Kalogeropoulos N, Kefalas P, Polissiou MG, Kaliora AC. (PubMed)
(3) Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities by Mitoshi M1, Kuriyama I, Nakayama H, Miyazato H, Sugimoto K, Kobayashi Y, Jippo T, Kanazawa K, Yoshida H, Mizushina Y. (PubMed)
(4) Physical Activity and Cancer by Jessica Clague and Leslie Bernstein. (PMC)
Herbal Cat's claw, The Anti Cancers Chemotherapeutic Remedy
Cat's claw found in the tropical jungles of South and Central America may have a potential effect in reducing the risk and treatment of the early onset of irregular cell growth, some scientists suggested.
Cancers are a class of chronic diseases associated with cell growth in the tissue and organs. At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.
There are many types of cancer, depending on the location where cancer begins.
As of today, researchers do not know what are the exact cause of cancers. however many researchers believe, exposure to the environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.
Genetic mutation od BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancer and alternation of gene PTEN.that suppress the growth of tumors also increase the risk of cancers.
Dr. N Parsa in the study "Environmental Factors Inducing Human Cancers" wrote, "(Environment toxins cause) genetic mutations that would eventually alter the normal pathway of cellular proliferation and differentiation. Genetic mutations in four groups of genes; (Oncogenes, Tumor suppressor genes, Apoptosis genes, and DNA repair genes) play a vital role in altering the normal cell division" and " Inhibition of carcinogenic exposures wherever possible should be the goal of cancer prevention programs to reduce exposures from all environmental carcinogens".
The statement illustrated that environmentally induced genetic alternation at the cellular levels can initiate the early onset of cancer.
According to the World Cancer Research Fund UK What you eat can have a big impact on your risk of developing cancer. eating too much fat and sugar and less of fruits and vegetables are the most prevalent risk factors of cancers.
Truly, "Cancer is a Preventable Disease that Requires Major Lifestyle Changes", Dr. Preetha Anand, the lead scientist in the medical literature said, "Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle" and "cancer prevention requires smoking cessation, increased ingestion of fruits and vegetables, moderate use of alcohol, caloric restriction, exercise, avoidance of direct exposure to sunlight, minimal meat consumption, use of whole grains, use of vaccinations, and regular check-ups".
Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The Chemical Ingredients
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchona, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine.
In the study of anti-cancer effect of the preparation Cat's claw in several cancer cell lines to determine the IC (50) values with different quantitative and qualitative oxindole alkaloid composition: B/W(37) --bark extracted in water at 37 °C, B/W(b)--bark extracted in boiling water, B/50E(37) --bark extracted in 50% ethanol at 37 °C, B/E(b)--bark extracted in boiling 96% ethanol, B/96E(37) --bark extracted in 96% ethanol at 37 °C and B/SRT--bark extracted in water and dichloromethane researchers found that
* A high correlation between the total oxindole alkaloid content (from 0.43% to 50.40% d.m.) and the antiproliferative activity of the preparations (IC(50) from >1000 μg/ml to 23.57 μg/ml).
* B/96E(37) and B/SRT were the most cytotoxic preparations
* B/96E(37) are most active against Lewis lung carcinoma (LL/2) [IC(50) =25.06 μg/ml], cervical carcinoma (KB) [IC(50) =35.69 μg/ml] and colon adenocarcinoma (SW707) [IC(50) =49.06 μg/ml].
* B/SRT was especially effective in inhibiting proliferation of cervical carcinoma (KB) [IC(50) =23.57 μg/ml], breastcarcinoma (MCF-7) [IC(50) =29.86 μg/ml] and lung carcinoma (A-549) [IC(50) =40.03 μg/ml].
* In animal studies on mice bearing Lewis lung carcinoma showed significant inhibition of tumor growth by B/W(37) administered for 21 days at daily doses of 5 and 0.5 mg (p=0.0009).
* There are no adverse effects in all preparations.
The results suggested that Cat's claw is effective against cancer through its cytotoxicity, however, the cancer cells inhibition is totally depending on the dose of concentrations.
Furthermore, in the study to reaffirm the traditional use of the preparations from Uncaria tomentosa, a South American Rubiaceae, for the treatment of infective, inflammatory and tumoral processes, researchers launched an investigation to test whether the pentacyclic oxindole alkaloid mitraphylline isolated from the dried inner bark of this plant species has a similar anticancer effect in human Ewing's sarcoma MHH-ES-1 and breast cancer MT-3 cell lines.
Administration at the IC (50) +/- SE values of17.15 +/- 0.82 microM for MHH-ES-1 and 11.80 +/- 1.03 microM for MT-3 for 30 hours exerted a clinically significant inhibition of the human sarcoma and breast cancer cell line in a dose-dependent manner.
The finding suggested that Cat's claw may have a chemotherapeutic effect in the prevention and treatment of cancer without inducing any adverse effects.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the preparations during the course of the disease will be necessary to complete the picture of Cat's claw anti-cancers possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Topical plant database (Rain tree)
(2) Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition by Pilarski R, Filip B, Wietrzyk J, Kuraś M, Gulewicz K.(PubMed)
(3) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines, by García Giménez D, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)
(4) Environmental Factors Inducing Human Cancers by N Parsa. (PMC)
(5) Cancer is a Preventable Disease that Requires Major Lifestyle Changes by Preetha Anand, Ajaikumar B. Kunnumakara, Chitra Sundaram, Kuzhuvelil B. Harikumar,Sheeja T. Tharakan, Oiki S. Lai, Bokyung Sung, and Bharat B. Aggarwal. (PMC)
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