Scientists may have found a tasty whole fruit for the prevention and treatment of benign prostatic hyperplasia (enlarged prostate) and prostate cancer with no side effects, according to studies.
Benign prostatic hyperplasia happened mostly in the older age population group is a condition of an enlarged prostate that can cause some serious urinary symptoms, such as blocking the flow of urine out of the bladder.
In many cases, an enlarged prostate can also induce bladder, urinary tract or kidney problems and prostate cancer.
Prostate cancer is slow growth and a medical condition characterized by cell growth disorderly and uncontrollably in the prostate tissue.
Most cases of prostate cancer start in the cell on the surface of the inner lining of the prostate gland
At the advanced stage, the cancerous cell can travel a distance away from the prostate to infect other healthy tissue, through blood and fluid circulation.
The causes of prostate cancer are unknown. Epidemiologically, researchers do know that the increase in age, ethnicity, family history, genetic preposition of BRCA1 and/or BRCA2 and agent orange exposure are associated with an increased risk of the disease.
Some researchers suggested that a poor eating habit and lifestyle are the most common risk factors associated with the onset of benign prostatic hyperplasia and prostate cancer. Therefore, by changing to a healthy diet, the risk of benign prostatic hyperplasia and prostate cancer may be preventable.
Dr. Devrim E, in the concern of the widespread of prostate cancer and benign prostatic hyperplasia (BPH), over last few decades said, "garlic and its preparations have been used for the treatment of prostate cancer and relief of BPH symptoms for decades. It is thought that the mechanism(s) through which garlic may show anti-cancer and anti-inflammatory effects".
These results suggested adding garlic into your diet daily can decrease the incidence of both benign prostatic hyperplasia and prostate cancer with no side effects.
Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
Starting at age 40, the levels of the by-product prolactin of testosterone of men increases, stimulating the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT triggering prostate enlargement and other problems. Therefore in order to prevent the symptoms of enlarged prostate is to naturally impend the conversion of testosterone to DHT. Unfortunately, aging is not the only cause of enlarged prostate. Prostate Cancer is defined as a condition of the abnormal proliferation of cells in the prostate.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
With an aim to find the natural compound which processes the potency to inhibit the benign prostatic hyperplasia (BPH), a common disease of the prostate that affects men as they age, and a risk factor for developing prostate cancer with no side effects, researchers at the Monash University looked into the anti BPH activity of lycopene found abundantly in the strawberry by searching the database of medical literature.
Out many medical studies were examined, only 8 published randomized controlled trials (RCTs) comparing lycopene to placebo (or other interventions) for the treatment of BPH and prostate cancer met the inclusion criteria were selected for this systematic review.
Meta-analysis of two studies indicated a decrease in PSA levels in men diagnosed with prostate cancer, who received lycopene compared to placebo.
In a human prostate epithelial cell line (P21) and two tumor cell lines (P21 tumor cell line 1 and 2) derived from the same patient, and a normal human breast epithelial cell line (B42) and a tumor line derived from it (B42 clone 16), researchers examined the cytotoxic effects of strawberry polyphenols.
By applying the polyphenol-rich extract derived from strawberry or anthocyanin or tannin-rich sub-fractions to the cell lines in doses varying from 50 to 1.5 microg/ml, researchers discovered the strawberry extract inhibited over 50% in cell survival of both the normal and the tumor lines with the doses of approximately 5 microg/ml.
The extracts were found to exert cytotoxicity to peripheral blood human lymphocytes with the doses higher levels 20 microg/ml for the similar effect of 50% reduction in cell survival.
Compound analysis assay suggested that the cytotoxicity was retained in the tannin-rich fraction was considerably more toxic to all cells (normal or tumor cell lines or lymphocytes) than the anthocyanin-rich fraction the tannin-rich fraction.
Furthermore, In LNCaP and PC-3) tumor cell lines, strawberry extract with concentrations of 50 microg/ml was required for 50% reduction in cell survival.
The finding suggested that strawberry processed high amounts of bioactive compounds may be considered a functional food for the prevention and treatment of benign prostatic hyperplasia (BPH) and prostate cancer without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Lycopene for the prevention and treatment of benign prostatichyperplasia and prostate cancer: a systematic review by Ilic D, Misso M.(PubMed)
(2) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed)
(3) Lycopene for the prevention of prostate cancer by Ilic D, Forbes KM, Hassed C.(PubMed)
(4) Is garlic a promising food for benign prostatic hyperplasia and prostate cancer? by Devrim E1, Durak I. (PubMed)
Monday, March 11, 2019
Manuka Honey, the Best for the Prevention and Treatment of Acute and Chronic Inflammatory Diseases
Honey may the next pharmaceutical target to identify the single ingredient medicine for the treatment of choric inflammatory disease, some scientists suggested.
Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.
After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulates the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms which may cause harm to our body.
In this acute phase of the battle, most of the times are won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead the death of nearby healthy cells and improper skin healing with the formation of scars.
In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.
Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.
Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.
In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.
Dr. Philip Hunter in the study "The inflammation theory of disease" pinpointed the important cause of diseases associated with chronic inflammation, "Maria Abreu's research group at the University of Miami's Miller School of Medicine in the USA found that the incidence of colon cancer was linked directly to the expression of the Toll-like receptor 4 (TLR4) gene".
"TLRs are crucial in alerting the immune system to microbial infection, triggering acute inflammatory responses that clear invading pathogens. However, TLR4 can also maintain chronic inflammation, for example by responding to commensal bacteria in the gut. As such bacteria are constantly replenished through food intake, and therefore cannot be permanently cleared by the immune system, this can lead to persistent chronic infection maintained by TLRs. "
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding an ingredient or whole food for the prevention and treatment of acute and chronic inflammatory diseases, scientists at the Menoufia University examine the honey effects in a rat model of colitis induced by the injection of dextran sodium sulfate (DSS).
Application of natural honey showed a strong effect in the prevention of tissue injury and inflammatory infiltration by inhibited by proteins associated with the production of proinflammatory cytokine and overexpression of reactive oxygen species.
Further examination of the honey effect, researchers indicated that the honey-treated group had significantly improved macroscopic and microscopic scores and inhibited the apoptotic markers.
At the end of the experiment, researchers said, "the beneficial role of natural honey in the treatment of DSS-induced colitis via the inhibition of colonic motor dysfunction and the inflammatory-oxidative-apoptotic cascade" and "the role of honey in epithelial regeneration was clarified", after taking into account co and confounders.
Moreover, in order to understand the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats, researchers examined the joint studies led by King Abdulaziz University, including 4 our groups of rats randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
During the stud, Manuka honey treated group displayed a significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.
Manuka honey treated group also showed increased levels of antioxidants enzymes which were suppressed by the injection of ethanol to an induced ulcer.
Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker and plasma of proinflammatory cytokines.
Dr. Almasaudi SB, the lead scientist wrote in the final report, "manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
Taken altogether, Manuka honey may be considered a functional food for the prevention of inflammation and combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis by Nooh HZ1, Nour-Eldien NM2.(PubMed)
(2) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(3) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.
After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulates the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms which may cause harm to our body.
In this acute phase of the battle, most of the times are won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead the death of nearby healthy cells and improper skin healing with the formation of scars.
In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.
Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.
Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.
In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.
Dr. Philip Hunter in the study "The inflammation theory of disease" pinpointed the important cause of diseases associated with chronic inflammation, "Maria Abreu's research group at the University of Miami's Miller School of Medicine in the USA found that the incidence of colon cancer was linked directly to the expression of the Toll-like receptor 4 (TLR4) gene".
"TLRs are crucial in alerting the immune system to microbial infection, triggering acute inflammatory responses that clear invading pathogens. However, TLR4 can also maintain chronic inflammation, for example by responding to commensal bacteria in the gut. As such bacteria are constantly replenished through food intake, and therefore cannot be permanently cleared by the immune system, this can lead to persistent chronic infection maintained by TLRs. "
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding an ingredient or whole food for the prevention and treatment of acute and chronic inflammatory diseases, scientists at the Menoufia University examine the honey effects in a rat model of colitis induced by the injection of dextran sodium sulfate (DSS).
Application of natural honey showed a strong effect in the prevention of tissue injury and inflammatory infiltration by inhibited by proteins associated with the production of proinflammatory cytokine and overexpression of reactive oxygen species.
Further examination of the honey effect, researchers indicated that the honey-treated group had significantly improved macroscopic and microscopic scores and inhibited the apoptotic markers.
At the end of the experiment, researchers said, "the beneficial role of natural honey in the treatment of DSS-induced colitis via the inhibition of colonic motor dysfunction and the inflammatory-oxidative-apoptotic cascade" and "the role of honey in epithelial regeneration was clarified", after taking into account co and confounders.
Moreover, in order to understand the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats, researchers examined the joint studies led by King Abdulaziz University, including 4 our groups of rats randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
During the stud, Manuka honey treated group displayed a significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.
Manuka honey treated group also showed increased levels of antioxidants enzymes which were suppressed by the injection of ethanol to an induced ulcer.
Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker and plasma of proinflammatory cytokines.
Dr. Almasaudi SB, the lead scientist wrote in the final report, "manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
Taken altogether, Manuka honey may be considered a functional food for the prevention of inflammation and combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis by Nooh HZ1, Nour-Eldien NM2.(PubMed)
(2) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(3) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
Sunday, March 10, 2019
Chinese Celery, the Prominent Post Stroke Treatment Functional Food
Scientists may have found a whole food for the treatment and improvement of the quality of life of post-stroke patients and without inducing any side effects, according to studies.
Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.
In other words, a stroke can either be results of a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).
A mini-stroke is a temporary disruption of blood flow to the brain that only causes some disruption to the brain with inducing permanent damage.
Depending on the parts of the neuron being damage, patients may experience different symptoms. However, most common symptoms of stroke include paralysis or numbness of the face, arm or leg, problems in vision, speaking, walking and persistent headache.
Certain medical conditions such as diabetes. heart diseases, long-term use of tobacco, the increase in age, ethnicity are some prevalent risk factors of stroke.
Out of many risk factors, people who have hypertension, particularly untreated hypertension and follow the Western diet are at increased risk of the onset of stroke, according to epidemiological studies.
In examining the post-stroke patients, a poor diet pattern with a high in saturated and trans fat, red meat and processed foods have been found in the high percentage, compared to the traditional diet.
Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in risk of stoke wrote, " adherence to the improvements in nutrition and diet can reduce the incidence of stroke. Higher antioxidant, vitamins, potassium, calcium, vegetables, fruits, whole grain intake, and adherence to the Mediterranean diet or DASH diet can lower stroke incidence".
The statement clearly suggested that a healthy diet rich in fruits and vegetable and whole grain and low in red meat, saturated fat and trans fat, and processed food is the best for prevention and stroke.
Celery is a species of Apium graveolens, belonging to the family Apiaceae. The plant is cultivated all around the globe as a vegetable.
Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
On finding a natural ingredient with no side effect for the treatment of patients with acute ischemic stroke, researchers evaluated the Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, efficacy in animal models of stroke.
The randomized, double-blind, double-dummy trial included 573 patients within 48 hours of onset of ischemic stroke in China.
Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14-day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin.
After taking into account co and confounder, among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP demonstrated a significant improvement than 14-day treatment with ozagrel as measured by the modified Rankin scale (mRS).
Where Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.
According to Barthel index at day 90, there is no significant difference among the three groups. The rate of adverse events was similar among the three groups.
Furthermore, on a stroke induced by the middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY), researchers compared the results of the pre-treatment of NBP administered to SHR and WKY daily for two months prior to MCAO and post-treatment of NBP given daily for seven consecutive days after MCAO.
In SHR, NBP pre- and post-treatment significantly lowered neurological deficit scores, reduced infarct volume, and minimized pathological changes in the penumbra area compared to oil-vehicle treated controls.
In other words, NBP pre- and post-treatment reduced the potential damage penumbra area through its neuroprotective activity.
However, in WKY, these beneficial effects were observed only in the post-treatment group, compared to SHR.
Dr. Zhang L, at the end of the experiment, wrote, "NBP could exert both preventive and therapeutic effects on ischemic stroke in SHR, but only exerted a therapeutic effect in WKY".
Taken altogether, Chinese celery processed high amounts of Dl-3-n-butylphthalide (NBP) may be considered a functional food for the post-treatment of patients with stroke.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial and Cui LY1, Zhu YC, Gao S, Wang JM, Peng B, Ni J, Zhou LX, He J, Ma XQ.(PubMed)
(2) DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment by Zhang L1, Yu WH, Wang YX, Wang C, Zhao F, Qi W, Chan WM, Huang Y, Wai MS, Dong J, Yew DT.(PubMed)
(3) Stroke and Nutrition: A Review of Studies by Mehdi Foroughi,2 Mohsen Akhavanzanjani,2 Zahra Maghsoudi,2 Reza Ghiasvand,1,2Fariborz Khorvash,3 and Gholamreza Askari. (PMC)
Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.
In other words, a stroke can either be results of a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).
A mini-stroke is a temporary disruption of blood flow to the brain that only causes some disruption to the brain with inducing permanent damage.
Depending on the parts of the neuron being damage, patients may experience different symptoms. However, most common symptoms of stroke include paralysis or numbness of the face, arm or leg, problems in vision, speaking, walking and persistent headache.
Certain medical conditions such as diabetes. heart diseases, long-term use of tobacco, the increase in age, ethnicity are some prevalent risk factors of stroke.
Out of many risk factors, people who have hypertension, particularly untreated hypertension and follow the Western diet are at increased risk of the onset of stroke, according to epidemiological studies.
In examining the post-stroke patients, a poor diet pattern with a high in saturated and trans fat, red meat and processed foods have been found in the high percentage, compared to the traditional diet.
Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in risk of stoke wrote, " adherence to the improvements in nutrition and diet can reduce the incidence of stroke. Higher antioxidant, vitamins, potassium, calcium, vegetables, fruits, whole grain intake, and adherence to the Mediterranean diet or DASH diet can lower stroke incidence".
The statement clearly suggested that a healthy diet rich in fruits and vegetable and whole grain and low in red meat, saturated fat and trans fat, and processed food is the best for prevention and stroke.
Celery is a species of Apium graveolens, belonging to the family Apiaceae. The plant is cultivated all around the globe as a vegetable.
Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
On finding a natural ingredient with no side effect for the treatment of patients with acute ischemic stroke, researchers evaluated the Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, efficacy in animal models of stroke.
The randomized, double-blind, double-dummy trial included 573 patients within 48 hours of onset of ischemic stroke in China.
Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14-day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin.
After taking into account co and confounder, among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP demonstrated a significant improvement than 14-day treatment with ozagrel as measured by the modified Rankin scale (mRS).
Where Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.
According to Barthel index at day 90, there is no significant difference among the three groups. The rate of adverse events was similar among the three groups.
Furthermore, on a stroke induced by the middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY), researchers compared the results of the pre-treatment of NBP administered to SHR and WKY daily for two months prior to MCAO and post-treatment of NBP given daily for seven consecutive days after MCAO.
In SHR, NBP pre- and post-treatment significantly lowered neurological deficit scores, reduced infarct volume, and minimized pathological changes in the penumbra area compared to oil-vehicle treated controls.
In other words, NBP pre- and post-treatment reduced the potential damage penumbra area through its neuroprotective activity.
However, in WKY, these beneficial effects were observed only in the post-treatment group, compared to SHR.
Dr. Zhang L, at the end of the experiment, wrote, "NBP could exert both preventive and therapeutic effects on ischemic stroke in SHR, but only exerted a therapeutic effect in WKY".
Taken altogether, Chinese celery processed high amounts of Dl-3-n-butylphthalide (NBP) may be considered a functional food for the post-treatment of patients with stroke.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial and Cui LY1, Zhu YC, Gao S, Wang JM, Peng B, Ni J, Zhou LX, He J, Ma XQ.(PubMed)
(2) DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment by Zhang L1, Yu WH, Wang YX, Wang C, Zhao F, Qi W, Chan WM, Huang Y, Wai MS, Dong J, Yew DT.(PubMed)
(3) Stroke and Nutrition: A Review of Studies by Mehdi Foroughi,2 Mohsen Akhavanzanjani,2 Zahra Maghsoudi,2 Reza Ghiasvand,1,2Fariborz Khorvash,3 and Gholamreza Askari. (PMC)
Honey, The Functional Food Which Kills Bladder Cancer Cells in Vivo and Vitro, Scientists Find
Scientists may have found a natural food source which processes the potential for the treatment of bladder cancer with no side effects, some studies suggested.
Bladder cancer is a medical condition characterized by irregular cell growth in the bladder.
Most cases of the primary bladder cancer start in the cell on the surface of the inner lining of the bladder tissue.
At the early stage, most bladder cancers do not cause any symptoms. However, at the advanced stage, the prostate can cause a distance metastasis to infect other healthy tissue and organ through the circulation of blood and fluids.
At this advanced stage, patients may experience symptoms of pain and blood in the urine caused by the proliferative tumor suppressing the nerve cells and breaking the blood vessels in the bladder.
Researchers do not the exact causes of bladder cancer. But certain risk factors such as tobacco use, aging, gender, ethnicity, long-term bladder condition and exposure to chemicals are at a higher risk of the onset of the disease.
The warning from the FDA also suggested the diabetes drug pioglitazone for more than 1 year may have a higher risk of developing bladder cancer.
In fact, most people with some of the above risk factors have never developed bladder cancer even they are associated with the increased risk all their life.
Although most scientists agree that tobacco use is the major cause of bladder cancer, genetic preposition, according to the epidemiological studies is also the substantial risk of bladder cancer, such as the genetic mutations in some chromosomal genes, such as FGFR3, RB1, HRAS, TP53, TSC1, and others, occur which form tumors in the urinary bladder.
Sadly, People with gene mutation are at the 70 % higher risk of bladder cancer compared to those do not.
Dr. Zhang X, the lead author in the study "Bladder Cancer and Genetic Mutations" specified, "The changes in the genes of human chromosome 9 are usually responsible for tumor in bladder cancer, but the genetic mutation of chromosome 22 can also result in bladder cancer". and "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".
And, "The 18 different bladder tumors were evaluated, and 11 (61 %) had genetic mutations of p53 gene".
Honey, is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient for the prevention and treatment of bladder cancer without inducing any side effects, researchers at the University of Tsukuba conducted an experiment to examine the antitumor effect of bee honey against bladder cancer in vitro and in vivo.
The study included three human bladder cancer cell lines (T24, 253J, and RT4) and one murine bladder cancer cell line (MBT-2).
In vitro studies application of honey significantly inhibited the proliferation of T24 and MBT-2 cell lines by 1-25% honey and of RT4 and 253J cell lines by 6-25% observed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.
Bromodeoxyuridine (BrdU) labeling index, an indicator of early tumor response to the injection of honey was lower in vitro.
FCM showed lower S-phase fraction, as well as the absence of aneuploidy compared with control cells.
Flowcytometry (FCM). in the measurement of can cancer cells physical and chemical characteristics showed lower S-phase fraction and the absence of aneuploidy compared with control cells, an indication of inhibitory cancer cells by the application of honey.
Furthermore, In the in vivo, intralesional injection of 6 and 12% honey, as well as oral ingestion of honey, significantly inhibited tumor growth.
These results suggested that bee honey processes a significant activity for inhibiting the growth of T24, RT4, 253J, and MBT-2 bladder cancer cell lines in vitro.
And, honey is also effective when administered intralesionally or orally in the MBT-2 bladder cancer implantation models.
Dr, Swellam T, the lead author after taking into account co and confounders wrote, " Our results are promising,,,,,, the mechanisms of the antitumor activity of honey".
Taken altogether, honey may be considered a functional food for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bladder cancer.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-bladder cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies by Swellam T1, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H. (PubMed)
(2) Bladder Cancer and Genetic Mutations by Zhang X1, Zhang Y. (PubMed)
Saturday, March 9, 2019
Herbal Aloe Vera Juice, the Potent Mouth Wash for Treatment of Oral Mucositis Caused by Chemo and Radiation Therapy in Patients with Head and Neck Cancer
Aloe vera may have a potential effect in reducing the oral mucositis in patients with head and neck cancer, some scientists suggested.
Head and neck cancer is a class of cancers that start in the mouth, throat, larynx, sinuses, or salivary glands.
At the early stage, cells on the surface of the inner lining associated with head and neck start to grow irregularly and disorderly.
However, at the advanced stage, as cancer has penetrated into the deeper layers, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.
In some cases at the advanced stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.
Most common head and neck cancer metastases are secondary skin cancer.
Oral mucositis is one of the common side effects in cancer patients who are under chemo and radiation treatment, leading to symptoms of pain, nutritional problems as a result of an inability to eat, and increased risk of infection due to open sores in the mucosa.
The symptom has been found to reduce the quality of life of cancer patients.
According to The Oral Cancer Foundation, patients experience the side effect of oral mucositis after 5 to 10 days of chemotherapy. Normally, the side effect will disappear itself in short few weeks, depending on the types of medicine, doses, and duration of the treatment.
Dr. Begonya Chaveli-López, the lead author in the study "Treatment of oral mucositis due to chemotherapy" wrote, "Very few interventions of confirmed efficacy are available for the management of oral mucositis due to chemotherapy. However, according to the reviewed literature, the use of palifermin, cryotherapy and low power laser offer benefits, reducing the incidence and severity of oral mucositis".
On finding a natural and effective ingredient for the treatment of oral mucositis with no side effects, researchers examined the topical Aloe vera, a widely used for mild sunburn, frostbites, and scalding burns for its effect on mucositis.
Aloe gel showed the beneficial effects of wound healing, mucous membrane protection, and treatment of oral ulcers.
Application of Aloe gel also enhanced the anti-inflammatory, immunomodulation, antifungal, scavenging free radicals, increasing collagen formation and inhibiting collagenase, epidemiological studies suggested.
Oral Aloe vera mouthwash demonstrated significant prevention of radiation-induced mucositis by its wound healing and anti-inflammatory mechanism.
The herbal mouthwash also reduced oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties.
These efficacies indicated that Aloe vera mouthwash may be considered an alternative potential for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers.
Futhermore, in the finding the most effective agent for treatment of oral mucositis, the Haji Mirza Mohammad conducted a triple-blind, randomized controlled trial in the comparison of the Aloe vera mouthwash with a benzydamine mouthwash in the alleviation of radiation-induced mucositis in head and neck cancer patients.
The trial included 26 eligible head and neck cancer patients who were to receive conventional radiation therapy at the radiation oncology department were randomized to receive an Aloe vera mouthwash or a benzydamine mouthwash.
No difference in the distribution of mucositis severity between the two groups, at the baseline.
The mean interval between radiation therapy and the onset of mucositis was similar for both groups.
The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days).
According to the comparison test researchers suggested that the Aloe vera mouthwash could be an alternative agent in the treatment of radiation-induced mucositis in patients with head and neck cancer due to its exertion of the similar effects as of those of beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis with no side effects.
Taken altogether, herbal Aloe vera juice may be considered a functional juice for the treatment of the side effect of oral mucositis caused by chemo and radiation therapy in patients with head and neck cancer
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. by Ahmadi A.(PubMed)
(3) Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial by Sahebjamee M, Mansourian A, Hajimirzamohammad M, Zadeh MT, Bekhradi R, Kazemian A, Manifar S, Ashnagar S, Doroudgar K.(PubMed)
Head and neck cancer is a class of cancers that start in the mouth, throat, larynx, sinuses, or salivary glands.
At the early stage, cells on the surface of the inner lining associated with head and neck start to grow irregularly and disorderly.
However, at the advanced stage, as cancer has penetrated into the deeper layers, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.
In some cases at the advanced stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.
Most common head and neck cancer metastases are secondary skin cancer.
Oral mucositis is one of the common side effects in cancer patients who are under chemo and radiation treatment, leading to symptoms of pain, nutritional problems as a result of an inability to eat, and increased risk of infection due to open sores in the mucosa.
The symptom has been found to reduce the quality of life of cancer patients.
According to The Oral Cancer Foundation, patients experience the side effect of oral mucositis after 5 to 10 days of chemotherapy. Normally, the side effect will disappear itself in short few weeks, depending on the types of medicine, doses, and duration of the treatment.
Dr. Begonya Chaveli-López, the lead author in the study "Treatment of oral mucositis due to chemotherapy" wrote, "Very few interventions of confirmed efficacy are available for the management of oral mucositis due to chemotherapy. However, according to the reviewed literature, the use of palifermin, cryotherapy and low power laser offer benefits, reducing the incidence and severity of oral mucositis".
On finding a natural and effective ingredient for the treatment of oral mucositis with no side effects, researchers examined the topical Aloe vera, a widely used for mild sunburn, frostbites, and scalding burns for its effect on mucositis.
Aloe gel showed the beneficial effects of wound healing, mucous membrane protection, and treatment of oral ulcers.
Application of Aloe gel also enhanced the anti-inflammatory, immunomodulation, antifungal, scavenging free radicals, increasing collagen formation and inhibiting collagenase, epidemiological studies suggested.
Oral Aloe vera mouthwash demonstrated significant prevention of radiation-induced mucositis by its wound healing and anti-inflammatory mechanism.
The herbal mouthwash also reduced oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties.
These efficacies indicated that Aloe vera mouthwash may be considered an alternative potential for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers.
Futhermore, in the finding the most effective agent for treatment of oral mucositis, the Haji Mirza Mohammad conducted a triple-blind, randomized controlled trial in the comparison of the Aloe vera mouthwash with a benzydamine mouthwash in the alleviation of radiation-induced mucositis in head and neck cancer patients.
The trial included 26 eligible head and neck cancer patients who were to receive conventional radiation therapy at the radiation oncology department were randomized to receive an Aloe vera mouthwash or a benzydamine mouthwash.
No difference in the distribution of mucositis severity between the two groups, at the baseline.
The mean interval between radiation therapy and the onset of mucositis was similar for both groups.
The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days).
According to the comparison test researchers suggested that the Aloe vera mouthwash could be an alternative agent in the treatment of radiation-induced mucositis in patients with head and neck cancer due to its exertion of the similar effects as of those of beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis with no side effects.
Taken altogether, herbal Aloe vera juice may be considered a functional juice for the treatment of the side effect of oral mucositis caused by chemo and radiation therapy in patients with head and neck cancer
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) ALOE VERA by Gertrude Baldwin, http://www.herballegacy.com/Baldwin_Chemical.html
(2) Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. by Ahmadi A.(PubMed)
(3) Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial by Sahebjamee M, Mansourian A, Hajimirzamohammad M, Zadeh MT, Bekhradi R, Kazemian A, Manifar S, Ashnagar S, Doroudgar K.(PubMed)
Ginger, The Spice Which Protects Our Body Against Inflammatory Diseases
Scientists may have found a pungent and kitchen spices which process a potential effect on the prevention and treatment of chronic inflammatory diseases without inducing any side effects.
Inflammation is a natural reaction of the immune system whose function is to protect our body against the invasion of the foreign stimuli and pathogens.
In the acute phase of tissue damage or injury, the white blood cells responsible for the first line of defense activate the production of the inflammatory cytokines to the site of infection with an aim to kill off the invasive agents.
However, in most cases, overproduction of inflammatory cytokines can damage the nearby cells and lead to improper healing with the formation of scars.
Chronic inflammation is an inflammation that lasts more than 3 months. The development and progression of chronic inflammatory diseases are the results of the immune system which can not kill off the invasive pathogens in the acute phase of infection or immune system mistakenly attacks the body tissue, leading to the persistently the low-grade inflammation.
In the further analysis of the evolution of physiological supersystems involved chronic inflammatory disease, Dr. Rainer H. Straub, the lead author said, "It is predicted that genes that protect energy stores are positively selected (as immune memory). This could explain why energy-demanding inflammatory episodes like infectious diseases must be terminated within 3–8 weeks to be adaptive, and otherwise become maladaptive:
These results suggested that the genes and networks used evolved during physiological supersystems, fitness consequences and during different life-history stages are positively selected if they serve acute, highly energy-consuming inflammation.
In other words, the immune system becomes maladaptive, if inflammation does not terminate within eight weeks of infection.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The kitchen has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding a natural ingredient for the treatment of inflammation without inducing any adverse effects, a joint study led by the CHA University, Seongnam was conducted to examine the molecular mechanism of 6-gingerol on adipocyte-mediated systemic inflammation in vitro and in high-fat-diet-induced obese zebrafish.
Injection of 6-gingerol exerted a significantly increased the production of anti-inflammatory cytokine interleukin-10 and decreased the expression of proinflammatory cytokines, TNFα, monocyte chemotactic protein-1, interleukin-1β, and interleukin-6.
In the RAW 264.7 macrophages, 6-gingerol inhibited the protein expression of proinflammatory factors TNFα and monocyte chemotactic protein-1, a small cytokine that belongs to the CC chemokine family.
6-Gingerol decreased c-JUN N-terminal kinase and I kappa B kinase beta which plays an important role in the inhibition of nuclear factor kappa-B kinase activated by multiple stimuli such as inflammatory cytokines
Where JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes including inflammation.
6-gingerol also decreased the expression of inducible nitric oxide synthase in the stimulation of the expression of inflammation.
Dr. Choi J, the lead scientists wrote in the final report, " 6-gingerol suppresses inflammation through the regulation of the c-JUN N-terminal kinase-I kappa B kinase beta and its downstream targets".
Furthermore, the investigation of the effects of 6-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone) in experimental models that HepG2 cells were exposed to 500 µmol/l oleic acid (OA) for 24 h and preincubated for an additional 24 h with 6-gingerol (25, 50 or 100 µmol/l). 6-Gingerol (100 µmol/l) inhibited OA-induced triglyceride and inflammatory marker accumulation in HepG2 cells of non-alcoholic steatohepatitis also suggested that
* Daily application of 6ginger for 8 weeks while maintained on HFD. 6-Gingerol (100 mg/kg/day) alleviated liver steatosis, inflammation, and reversed
* [6]-gingerol also attenuated the expression of inflammatory cytokine genes and nuclear transcription factor-κB (NF-κB) increased in the HFD group.
The results strongly indicated 6-Gingerol attenuates HFD-induced steatohepatitis by downregulating NF-κB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.
More interestingly, in the study includes five groups of rats containing 14 rats/group received corn oil (control), CPF (5 mg/kg), 6-GRF (100 mg/kg), CPF (5 mg/kg) + 6-GRF (50 mg/kg) and CPF (5 mg/kg) + 6-GRF (100 mg/kg) through gavage once per day for 35 days respectively, researchers showed that
* Before 6-gingerol application CPF-induced rats showed an increase in oxidative stress ((hydrogen peroxide (H2O2) and malondialdehyde (MDA)), inflammatory (myeloperoxidase (MPO), nitric oxide (NO) nitric oxide (NO) and tumor necrosis factor-α (TNF- α)), and apoptotic (caspase-3) markers.
* Injection of 6-gingerol attenuated all factors in the CPF induced rats.
* 6-GRF reduced the inflammatory expression through improving the activities of antioxidant enzymes catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) as well as glutathione (GSH) level in the brain, ovary, and uterus of rats exposed to CPF.
Dr. Abolaji AO the lead author said, " the protective effects of 6-GRF on CPF-induced toxicity in the brain and reproductive organs of rats may be due to it's potent antioxidative, anti-inflammatory and antiapoptotic properties".
Where Chlorpyrifos (CPF) is an organophosphorus pesticide widely used in agricultural applications and household environments.
Taken all together, ginger processed abundantly 6-gingerol may be considered a functional kitchen spice for the prevention and treatment of inflammation.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 6-Gingerol Suppresses Adipocyte-Derived Mediators of Inflammation In Vitro and in High-Fat Diet-Induced Obese Zebra Fish by Choi J1, Kim KJ1, Kim BH2, Koh EJ1, Seo MJ1, Lee BY. (PubMed)
(2) [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis by Tzeng TF1, Liou SS1, Chang CJ1, Liu IM. (PubMed)
(3) Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary, and uterus of rats by Abolaji AO1, Ojo M2, Afolabi TT2, Arowoogun MD2, Nwawolor D2, Farombi EO. (PubMed)
Friday, March 8, 2019
Manuka Honey (MH) and Tualang Honey (TH), the Potential Natural Antibiotics Alternative with No Side Effects
Scientists may have found natural alternative antibiotics for the treatment of diseases caused by a bacterial infection, some studies found.
Infection is a medical condition caused by bacteria multiplication after entering the body.
Most bacteria were killed off by the white blood cells of the first line of defense of the immune system before they can enter the body.
In this stage, the immune systematic response stimulates the production of proteins associated with the production of coagulation to seal the wound and damage and pro-inflammatory cytokines to destroy the invaded bacteria, leading to symptoms of fever, skin redness in the infected area.
However, if they enter the body successfully, they can initiate infection through the stage of incubation where bacterial multiplying in the specific tissues and organs, leading to the colonization and in facilitating diseases development.
Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.
Some bacterial pathogens can establish life-long chronic infections in the host by persistent establishment after an acute infection period.
Dr. Young D, the lead scientist, at the Technology and Medicine, said," Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection"
" Persistent bacterial infection may involve occupation of a particular tissue type or organ or modification of the intracellular environment within eukaryotic cells".
"Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors".
These result firmly suggested that if you have a weakened immune system you are at a higher risk to the onset of chronic bacterial infection.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding natural sources as a new antibiotic with no side effects, researchers examine the Manuka honey (MH) antibacterial effect in bioactive wound dressings.
Epidemiological studies suggested that MH provides unique antibacterial activity compared to conventional kinds of honey, due to its constituents, methylglyoxal (MGO).
In the evaluation of the antibacterial activity of both MH and MGO (at equivalent MGO concentrations) when applied as a physical coating to a nonwoven fabric wound dressing, researchers found that* Application of concentrations of 0.0054 mg cm-2 of MGO in the form of MH and MGO is sufficient to achieve a 100 colony forming unit % bacteria reduction against gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumonia.
* However, a 3- to 20-fold increase in MGO concentration (0.0170-0.1 mg cm-2) was required to facilitate a good antibacterial effect.
These results suggested that Manuka honey antibacterial activity processed a linearly and MGO concentration-dependent manner.
Dr. Bulman SEL, the lead scientist said, "The results presented in this study, therefore, demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries".
Additionally, in the investigation of the traditional use of Tualang honey (TH) for the treatment of bacterial infection against various microorganisms, including those from burn-related diagnoses, compared the anti antibacterial activity of Aquacel-Tualang honey, Aquacel-Manuka honey, Aquacel-Ag, and Aquacel- plain dressings against bacteria isolated from patients.
Four types of Gram-negative bacteria, namely Enterobacter cloacae, Klebsiella pneumoniae, Pseudomonas spp. and Acinetobacter spp., and three Gram-positive bacteria, namely Staphylococcus aureus, coagulase-negative Staphylococcus aureus (CONS) and Streptococcus spp. were included in the study.
All tested agents showed a significant effect inhibiting the total bacterial count on day 6 and onwards.
Aquacel-Ag and Aquacel-Manuka honey dressings gave a better zone of inhibition for Gram-positive bacteria compared to Aquacel-Tualang honey dressing.
The comparable results were also found in the Aquacel-Manuka honey and Aquacel-Tualang honey dressing against Gram-negative bacteria.
Researchers after taking into account co and confounders suggested that Tualang honey has a bactericidal as well as bacteriostatic effect and is easier to apply and less sticky compared to Manuka honey.
Taken altogether, there is no doubt that Manuka honey (MH) and Tualang honey (TH) may be considered a functional remedy for the prevention and treatment of bacterial infection. However, before they can be used as antibiotics similar to those of conventional medicine, a larger and multicenter human study is necessary to reconfirm the viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal by Bulman SEL1, Tronci G2, Goswami P3, Carr C4, Russell SJ5.(PubMed)
(2) Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study by Nasir NA1, Halim AS, Singh KK, Dorai AA, Haneef MN.(PubMed)
(3) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey by Tan HT1, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(PubMed)
(4) Chronic bacterial infections: living with unwanted guests by Young D1, Hussell T, Dougan G.(PubMed)
Infection is a medical condition caused by bacteria multiplication after entering the body.
Most bacteria were killed off by the white blood cells of the first line of defense of the immune system before they can enter the body.
In this stage, the immune systematic response stimulates the production of proteins associated with the production of coagulation to seal the wound and damage and pro-inflammatory cytokines to destroy the invaded bacteria, leading to symptoms of fever, skin redness in the infected area.
However, if they enter the body successfully, they can initiate infection through the stage of incubation where bacterial multiplying in the specific tissues and organs, leading to the colonization and in facilitating diseases development.
Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.
Some bacterial pathogens can establish life-long chronic infections in the host by persistent establishment after an acute infection period.
Dr. Young D, the lead scientist, at the Technology and Medicine, said," Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection"
" Persistent bacterial infection may involve occupation of a particular tissue type or organ or modification of the intracellular environment within eukaryotic cells".
"Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors".
These result firmly suggested that if you have a weakened immune system you are at a higher risk to the onset of chronic bacterial infection.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding natural sources as a new antibiotic with no side effects, researchers examine the Manuka honey (MH) antibacterial effect in bioactive wound dressings.
Epidemiological studies suggested that MH provides unique antibacterial activity compared to conventional kinds of honey, due to its constituents, methylglyoxal (MGO).
In the evaluation of the antibacterial activity of both MH and MGO (at equivalent MGO concentrations) when applied as a physical coating to a nonwoven fabric wound dressing, researchers found that* Application of concentrations of 0.0054 mg cm-2 of MGO in the form of MH and MGO is sufficient to achieve a 100 colony forming unit % bacteria reduction against gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumonia.
* However, a 3- to 20-fold increase in MGO concentration (0.0170-0.1 mg cm-2) was required to facilitate a good antibacterial effect.
These results suggested that Manuka honey antibacterial activity processed a linearly and MGO concentration-dependent manner.
Dr. Bulman SEL, the lead scientist said, "The results presented in this study, therefore, demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries".
Additionally, in the investigation of the traditional use of Tualang honey (TH) for the treatment of bacterial infection against various microorganisms, including those from burn-related diagnoses, compared the anti antibacterial activity of Aquacel-Tualang honey, Aquacel-Manuka honey, Aquacel-Ag, and Aquacel- plain dressings against bacteria isolated from patients.
Four types of Gram-negative bacteria, namely Enterobacter cloacae, Klebsiella pneumoniae, Pseudomonas spp. and Acinetobacter spp., and three Gram-positive bacteria, namely Staphylococcus aureus, coagulase-negative Staphylococcus aureus (CONS) and Streptococcus spp. were included in the study.
All tested agents showed a significant effect inhibiting the total bacterial count on day 6 and onwards.
Aquacel-Ag and Aquacel-Manuka honey dressings gave a better zone of inhibition for Gram-positive bacteria compared to Aquacel-Tualang honey dressing.
The comparable results were also found in the Aquacel-Manuka honey and Aquacel-Tualang honey dressing against Gram-negative bacteria.
Researchers after taking into account co and confounders suggested that Tualang honey has a bactericidal as well as bacteriostatic effect and is easier to apply and less sticky compared to Manuka honey.
Taken altogether, there is no doubt that Manuka honey (MH) and Tualang honey (TH) may be considered a functional remedy for the prevention and treatment of bacterial infection. However, before they can be used as antibiotics similar to those of conventional medicine, a larger and multicenter human study is necessary to reconfirm the viability.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal by Bulman SEL1, Tronci G2, Goswami P3, Carr C4, Russell SJ5.(PubMed)
(2) Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study by Nasir NA1, Halim AS, Singh KK, Dorai AA, Haneef MN.(PubMed)
(3) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey by Tan HT1, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(PubMed)
(4) Chronic bacterial infections: living with unwanted guests by Young D1, Hussell T, Dougan G.(PubMed)
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