Scientists may have found a natural resource for the prevention and treatment of diabetes with no side effects, according to the studies.
Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.
The diabetes is either caused by cells in pancreas died off due to the immune system mistakenly attacked the sell in the pancreas or receptor sites clogged up as a result of the excess fat and cholesterol in the bloodstream.
Researchers do not know why the immune system attacks its own tissue. Either they can explain people follow a lifelong intake of the Western diet, only some are susceptible to the onset of the disease, while others do not.
There are many risk factors such as age, ethnicity, family history, impaired glucose tolerance, insulin resistance, being an overweight or obese and sedentary lifestyle. associated with the onset of the condition, epidemiologically. However, many people with some of the risk factors have never developed diabetes.
Some researchers suggested that unhealthy diet with high amounts of saturated and trans fat, red meat and processed foods and low amounts of fruits and vegetable as that of the Western diet is the most common risk factor of diabetes in the Western world.
Dr. David Hefner, in the concern of the Western diet in risk of diabetes, wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes".
And, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
The results strongly suggested the risk of diabetes can be decreased with the change of diet pattern, from the Western diet to a healthy diet with high amounts of fruits and vegetables.
If you experience some of the belove symptoms such as increased thirst that can not be resolved by intake of liquid, frequent urination, extreme hunger, and unexplained weight loss, you may have type 2 diabetes. Please make sure you check with your doctor to rule out the possibility.
Phytic acid (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
On finding a natural bioactive compound for the treatment of diabetes with no side effects, researchers examined the effect of the phytic acid supplement on streptozotocin-induced diabetic rats.
Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. According to the assay used for the experiment, phytic acid supplement treated group showed an increase in average food intake and a decrease in body weight gain compared to the diabetic and normal control groups.
Compared to other groups, phytic acid supplement treated group also exerted a downtrend in intestinal amylase activity. The spike in random blood glucose in the treatment group also lower compared to others.
Furthermore, the treatment group also displays reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels and levels of serum alkaline phosphatase and alanine aminotransferase activities, the indication of improvement of insulin sensitivity.
Moreover, levels of pro-inflammatory cytokines also lower in phytic acid supplement treated group compared to other groups.
Dr.Omoruyi FO, the lead scientist at the end of the study, wrote, "phytic acid supplementation may be beneficial in the management of diabetes mellitus".
Additionally, researchers randomly assigned six groups of rats fed to test the anti-diabetes of phytic acid, for 3 weeks as follows:
* Groups 1 and 2 were fed formulated diets supplemented with zinc or without zinc respectively.
* Groups 3 and 4 were fed formulated diets supplemented with zinc plus phytic acid extracted from sweet potato (Ipomea batatas) or commercial phytic acid respectively.
* Groups 5 and 6 were fed formulated diets supplemented with a phytic acid extract from sweet potato or commercial phytic acid respectively.
At the final day of the experiment, researchers found that phytic acid extract consumption from sweet potato and commercial phytic acid plus zinc supplement lowered blood glucose levels.
However, phytic acid supplementation showed no significant decrease in the activity of pyruvate kinase involved in the insulin stimulation of this enzyme activity, compared to the group fed formulated diets.
Groups fed phytic extract from sweet potato also exerted a significant increase in the activity of glucose-6-phosphate dehydrogenase in the promotion of pancreatic beta-cell function, compared to the other groups.
Taken altogether, phytochemical phytic acid may be used for the prevention and combined with the primary medicine for the treatment and management of type 2 diabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats by Omoruyi FO1, Budiaman A1, Eng Y1, Olumese FE2, Hoesel JL3, Ejilemele A3, Okorodudu AO (PubMed)
(2) The effect of phytic acid on the levels of blood glucose and some enzymes of carbohydrate and lipid metabolism by Dilworth LL, Omoruyi FO, Simon OR, Morrison EY, Asemota HN(PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (NMA)
Thursday, March 21, 2019
Phytochemical Piperine, the Potent Immune System Enhancer, According to Studies
Scientists may have found an alkaloid in black pepper for the enhancement of the immune function with no side effects, according to studies.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
Through the expression of the lines of defense, depending on the stage of pathogenic invasion, the innate immune response protects the body via a different set of interaction.
In the acute phase of infection, the macrophages in the immune system stimulate the production of inflammatory cytokines to the site of the damage. The inflammatory cytokines not only play a critical role in stopping the stimuli from entering into the body but also speeds up the wound healing through growth factors.
The innate immune system also can destroy the damage cells such as cancer cell through the T cell activation of B cells which in turn stimulates the production of a protein associated with the production of antibody p53.
Some researchers suggested immune system also can kill cancer cells by reacting to activating cytokines (IFN-α/β, IL-12, IL-15, IL-18, IL-21) produced by tumor cells or by other immune cells stimulated by tumor cells.
Therefore, by modulating the immune responses to the needs of the body, the immune can keep us strong and diseases free.
Dr. Assaf Marcus and colleagues in the investigation of the study "Recognition of tumors by the innate immune system and natural killer cells" wrote, " First, cell-intrinsic mechanisms, like any other mechanism, are prone to failure, necessitating the existence of redundant systems. A second, unique, benefit of immune mechanisms of tumor suppression is that they can act in a paracrine manner. Secretion of cytokines such as IFN-γ, for example, can suppress the growth of neighboring tumor cells even if they do not upregulate immune-activating ligands".
And, "Secretion of cytokines such as IFN-γ, for example, can suppress the growth of neighboring tumor cells".
These results clearly suggested by keeping your immune system strong, you can be free for infectious diseases and cancers.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
With an aim to find a natural bioactive compound which processes the immune enhancing effect researchers assessed the production of antibody response against Russell's viper venom in mice after prophylactic immunization with ethanolic extract of fruits of Piper longum L. and piperine, compared to that of the Polyvalent anti-snake venom serum (antivenom)(PLE) manufactured by Haffkine Bio-Pharmaceutical Corporation Ltd.
According to the results from the tested assay, treatment with PLE-treated mice serum and piperine-treated mice serum was found to inhibit the lethal action of venom both in the in vitro.
Futhermore, there were significantly high (p<0.01) levels of cross-reactions between the PLE and piperine treated mice serum and the venom antigens.
However, immunization with ethanolic extract of fruits of Piper longum and piperine produced a high titer antibody response against Russell's viper venom in mice, compared to PLE.
These results suggested that piperine stimulated the immune function in producing antigens against the lethal action of venom may be considered a potential for the development of antivenom formulation as an antidote against snake bites.
In embryonated fertile chicken eggs, researchers found that PLE was found to inhibit the venom-induced hemorrhage in the eggs.
Combined administration of PLE and piperine significantly inhibited venom-induced lethality, hemorrhage, necrosis, defibrinogenation and inflammatory paw edema in mice in a dose-dependent manner.
LE and piperine also significantly (p<0.01) reduced venom-induced mast cell degranulation in rats by improving the immune responses to inflammatory and allergic reactions.
Before treatment, the injection of venom in mice showed reduced levels of catalase enzyme levels in mice kidney tissue and an increase in creatine kinase enzyme levels, the indication of inflammation.
Combined administration of both PLE and piperine also restored the antioxidant enzymes which were suppressed by the injection of venom in mice
These findings suggested that piperine not only protects our body against venom-induced hemorrhage, necrosis, defibrinogenation but also inhibited an overreaction of the immune response in the stimulation of inflammation.
Moreover, piperine is effective compared to those of antivenom medicine.
Taken altogether, Piperine may be considered a bioactive compound for the treatment of venom caused by insect and poison animal bites, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Production of high titre antibody response against Russell's viper venom in mice immunized with ethanolic extract of fruits of Piper longum L. (Piperaceae) and piperine by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(2) Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell's viper venom: characterization of piperine as active principle by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(3) Recognition of tumors by the innate immune system and natural killer cells by Assaf Marcus, Benjamin G. Gowen, Thornton W. Thompson, Alexandre Iannello, Michele Ardolino, Weiwen Deng, Lin Wang, Nataliya Shifrin, and David H. Raulet. (PMC)
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
Through the expression of the lines of defense, depending on the stage of pathogenic invasion, the innate immune response protects the body via a different set of interaction.
In the acute phase of infection, the macrophages in the immune system stimulate the production of inflammatory cytokines to the site of the damage. The inflammatory cytokines not only play a critical role in stopping the stimuli from entering into the body but also speeds up the wound healing through growth factors.
The innate immune system also can destroy the damage cells such as cancer cell through the T cell activation of B cells which in turn stimulates the production of a protein associated with the production of antibody p53.
Some researchers suggested immune system also can kill cancer cells by reacting to activating cytokines (IFN-α/β, IL-12, IL-15, IL-18, IL-21) produced by tumor cells or by other immune cells stimulated by tumor cells.
Therefore, by modulating the immune responses to the needs of the body, the immune can keep us strong and diseases free.
Dr. Assaf Marcus and colleagues in the investigation of the study "Recognition of tumors by the innate immune system and natural killer cells" wrote, " First, cell-intrinsic mechanisms, like any other mechanism, are prone to failure, necessitating the existence of redundant systems. A second, unique, benefit of immune mechanisms of tumor suppression is that they can act in a paracrine manner. Secretion of cytokines such as IFN-γ, for example, can suppress the growth of neighboring tumor cells even if they do not upregulate immune-activating ligands".
And, "Secretion of cytokines such as IFN-γ, for example, can suppress the growth of neighboring tumor cells".
These results clearly suggested by keeping your immune system strong, you can be free for infectious diseases and cancers.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
With an aim to find a natural bioactive compound which processes the immune enhancing effect researchers assessed the production of antibody response against Russell's viper venom in mice after prophylactic immunization with ethanolic extract of fruits of Piper longum L. and piperine, compared to that of the Polyvalent anti-snake venom serum (antivenom)(PLE) manufactured by Haffkine Bio-Pharmaceutical Corporation Ltd.
According to the results from the tested assay, treatment with PLE-treated mice serum and piperine-treated mice serum was found to inhibit the lethal action of venom both in the in vitro.
Futhermore, there were significantly high (p<0.01) levels of cross-reactions between the PLE and piperine treated mice serum and the venom antigens.
However, immunization with ethanolic extract of fruits of Piper longum and piperine produced a high titer antibody response against Russell's viper venom in mice, compared to PLE.
These results suggested that piperine stimulated the immune function in producing antigens against the lethal action of venom may be considered a potential for the development of antivenom formulation as an antidote against snake bites.
In embryonated fertile chicken eggs, researchers found that PLE was found to inhibit the venom-induced hemorrhage in the eggs.
Combined administration of PLE and piperine significantly inhibited venom-induced lethality, hemorrhage, necrosis, defibrinogenation and inflammatory paw edema in mice in a dose-dependent manner.
LE and piperine also significantly (p<0.01) reduced venom-induced mast cell degranulation in rats by improving the immune responses to inflammatory and allergic reactions.
Before treatment, the injection of venom in mice showed reduced levels of catalase enzyme levels in mice kidney tissue and an increase in creatine kinase enzyme levels, the indication of inflammation.
Combined administration of both PLE and piperine also restored the antioxidant enzymes which were suppressed by the injection of venom in mice
These findings suggested that piperine not only protects our body against venom-induced hemorrhage, necrosis, defibrinogenation but also inhibited an overreaction of the immune response in the stimulation of inflammation.
Moreover, piperine is effective compared to those of antivenom medicine.
Taken altogether, Piperine may be considered a bioactive compound for the treatment of venom caused by insect and poison animal bites, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Production of high titre antibody response against Russell's viper venom in mice immunized with ethanolic extract of fruits of Piper longum L. (Piperaceae) and piperine by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(2) Anti-snake venom activities of ethanolic extract of fruits of Piper longum L. (Piperaceae) against Russell's viper venom: characterization of piperine as active principle by Shenoy PA, Nipate SS, Sonpetkar JM, Salvi NC, Waghmare AB, Chaudhari PD.(PubMed)
(3) Recognition of tumors by the innate immune system and natural killer cells by Assaf Marcus, Benjamin G. Gowen, Thornton W. Thompson, Alexandre Iannello, Michele Ardolino, Weiwen Deng, Lin Wang, Nataliya Shifrin, and David H. Raulet. (PMC)
Wednesday, March 20, 2019
Bilberry May Process Anti Breast Cancer Potency with No Side Effects, According to Medical Literature
Bilberry may be the next potential and therapeutic treatment of breast cancer with no side effects, according to studies.
Breast cancer is the chronic condition characterized by irregular cells growth in the breast tissue caused by the alternation of DNA.
The causes of breast cancer are unknown, As of today, researchers cannot explain why people with the same health conditions in the same family, some are susceptible to the onset of breast cancer while others do not.
According to the statistics, 1 in 8 U.S. women, representing 12.4 % of all women will develop invasive breast cancer over the course of her lifetime.
Believe or not, In 2018, approximately 266,120 new cases of invasive breast cancer were diagnosed in women in the U.S.
The 5 years survival rate of breast cancer diagnosis at the early stage is 100%. Therefore, women at a higher risk of breast cancer should examine their breast at least once a month for preventive measure.
Most cases of breast cancer begin in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
Women with breast cancer may experience symptoms of lump, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, and scaliness.
If you experience some of the above symptoms, please make sure to check with your doctor as soon as possible to rule out the possibility of breast cancer.
In North America, some researchers suggested that obesity may have some strong impact on the risk of breast cancer onset.
Dr. Manuel Picon‐Ruiz, the lead scientist in the study of "Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention", wrote "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
And, " the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".
The results clearly suggested that if you are obese, your risk of breast cancer is increased substantially, compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of breast cancer examined the bilberry effect on the MCF7 human breast cancer cells.
Bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.3-0.4 mg/mL.
At this concentration, the natural compound also concerts the induction of apoptotic cell death of the cancer cells with no apparent effect on the microtubule that provides structure and shape to the cytoplasm of eukaryotic cells or actin cytoskeletons.
In other words, bilberry extract induced cancer cell apoptosis was not through cell cycle arrest at this concentration.
However, at the higher extract concentrations (0.5-0.9 mg/mL), the extract did cause an increase in the fraction of cells at the G(2)/M phase of the cell cycle.
Further differentiation of the cell death, bilberry extract at 0.3-0.4 mg/mL did not appreciably inhibit microtubule polymerization in vitro, but significant inhibition of polymerization (approximately 30%) did occur at higher extract concentrations (0.5-1 mg/mL).
Moreover, researchers found that the efficacy of bilberry against breast cancer cell was attributed not by the expression of anthocyanins but all phytochemicals in the extracts.
Dr. Nguyen V and colleagues wrote in the final report, " (Bilberry extract) inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis.
And, "At somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules".
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of breast cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells by Nguyen V1, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., Cynthia Morata‐Tarifa, Ph.D., Janeiro J. Valle‐Goffin, MD, Eitan R. Friedman, MD, and Joyce M. Slingerland, MD, Ph.D. (PMC)
Breast cancer is the chronic condition characterized by irregular cells growth in the breast tissue caused by the alternation of DNA.
The causes of breast cancer are unknown, As of today, researchers cannot explain why people with the same health conditions in the same family, some are susceptible to the onset of breast cancer while others do not.
According to the statistics, 1 in 8 U.S. women, representing 12.4 % of all women will develop invasive breast cancer over the course of her lifetime.
Believe or not, In 2018, approximately 266,120 new cases of invasive breast cancer were diagnosed in women in the U.S.
The 5 years survival rate of breast cancer diagnosis at the early stage is 100%. Therefore, women at a higher risk of breast cancer should examine their breast at least once a month for preventive measure.
Most cases of breast cancer begin in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
Women with breast cancer may experience symptoms of lump, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, and scaliness.
If you experience some of the above symptoms, please make sure to check with your doctor as soon as possible to rule out the possibility of breast cancer.
In North America, some researchers suggested that obesity may have some strong impact on the risk of breast cancer onset.
Dr. Manuel Picon‐Ruiz, the lead scientist in the study of "Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention", wrote "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
And, " the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".
The results clearly suggested that if you are obese, your risk of breast cancer is increased substantially, compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of breast cancer examined the bilberry effect on the MCF7 human breast cancer cells.
Bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.3-0.4 mg/mL.
At this concentration, the natural compound also concerts the induction of apoptotic cell death of the cancer cells with no apparent effect on the microtubule that provides structure and shape to the cytoplasm of eukaryotic cells or actin cytoskeletons.
In other words, bilberry extract induced cancer cell apoptosis was not through cell cycle arrest at this concentration.
However, at the higher extract concentrations (0.5-0.9 mg/mL), the extract did cause an increase in the fraction of cells at the G(2)/M phase of the cell cycle.
Further differentiation of the cell death, bilberry extract at 0.3-0.4 mg/mL did not appreciably inhibit microtubule polymerization in vitro, but significant inhibition of polymerization (approximately 30%) did occur at higher extract concentrations (0.5-1 mg/mL).
Moreover, researchers found that the efficacy of bilberry against breast cancer cell was attributed not by the expression of anthocyanins but all phytochemicals in the extracts.
Dr. Nguyen V and colleagues wrote in the final report, " (Bilberry extract) inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis.
And, "At somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules".
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of breast cancer, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells by Nguyen V1, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., Cynthia Morata‐Tarifa, Ph.D., Janeiro J. Valle‐Goffin, MD, Eitan R. Friedman, MD, and Joyce M. Slingerland, MD, Ph.D. (PMC)
Artichoke Protects Us Against Heart Disease, According to Studies
Artichoke may be used as a natural and herbal remedy for the treatment of heart disease with no side effects, according to studies.
Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.
According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.
Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.
Most common risk factors associated with heart disease are aging, family history with heart disease, metabolic syndrome, high blood pressure and cholesterol, obesity, smoking, and stress epidemiologically.
However, most people with some of the above risk factors have never developed heart disease. Symptoms of heart disease completely depend on the infected location.
Some researchers suggested that by making a change in lifestyle accompanied by moderate physical activity such as walking, the risk of heart disease can be prevented.
The American College of Cardiology wrote in the article of Heart Disease: Lifestyle Changes to Lower Risk. "Start slowly, and go at a pace you can manage. Try to do at least 2½ hours of moderate exercise a week. One way to do this is to be active 30 minutes a day, at least 5 days a week".
"Healthy eating starts with learning new ways to eat, such as adding more fresh fruits, vegetables, and whole grains and cutting back on foods that have a lot of saturated fat, sodium, and sugar"
"Getting active and eating a healthy diet can help you lose extra weight and quit smoking"
Finally, the article continued, "Even though you are taking medicine, it is always important to make lifestyle changes that keep your heart and your body healthy".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae, native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Finding a natural ingredient for the treatment of cardiovascular diseases has been a dream of many scientists. Researchers at the joint study led by the IRCCS San Raffaele Pisana, examined the effects of vegetables, including artichoke on CVD.
The joint study included a total of 38 subjects at risk of CVD. After, a week of the run-in period, participants were randomly assigned to one of the following 4-week interventions: low vegetable consumption (800 g of vegetables/week) or high vegetable consumption (4200 g of vegetables/week).
According to the assays that record immunological, and antioxidant markers, leukocyte and lymphocyte expression of the gut-homing β7 integrin, there were no significant changes detected in clinical, immunological, and antioxidant markers in biological samples, except for an increase in white blood cell count for the low vegetable consumption group.
Immune system's innate and adaptive immune responses play an essential role in the development and progression of cardiovascular diseases by inhibiting the pro-inflammatory expression.
Vegetable consumption group exerts a CVD protective effect in modulating markers of immune function and antioxidant status in patients with CVD. In healthy individuals, intake of vegetables does not induce a change of both antioxidant and inflammatory markers associated with immune function, particularly in nonsmoking men.
These results strongly suggested that vegetables modulate the function of the immune system according to the needs of the body.
In other to reveal more information about artichoke anti CVD activity, Dr. Rondanelli M and colleagues at the University of Pavia investigated the artichoke extracts on the cardiovascular disease on both animals and man.
Injection of artichoke not only reduced the levels of cholesterol in the bloodstream through its hypolipidemic activity but also inhibited the expression of high blood glucose and free radicals through the antioxidant and hypoglycemic activity.
The results indicated artichoke reduced the risk and progression of cardiovascular disease by improving the production of antioxidant enzymes against oxidative stress in the initiation of low-grade inflammation, a hallmark of CVD.
Futhermore, artichoke also decreases the levels of blood cholesterol and glucose, the cluster conditions associated with the risk CVD, epidemiologically.
Taken altogether, artichoke which processes anti cardiovascular diseases activity through several mechanisms may be considered a functional remedy for the prevention and treatment of cardiovascular diseases, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases by Peluso I1, Raguzzini A1, Catasta G1, Cammisotto V1, Perrone A1, Tomino C2, Toti E1, Serafini M. (Hindawi)
(2) Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action by Rondanelli M1, Monteferrario F, Perna S, Faliva MA, Opizzi A. (PubMed)
(3) Heart Disease: Lifestyle Changes to Lower Risk by The American College of Cardiology
Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.
According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.
Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.
Most common risk factors associated with heart disease are aging, family history with heart disease, metabolic syndrome, high blood pressure and cholesterol, obesity, smoking, and stress epidemiologically.
However, most people with some of the above risk factors have never developed heart disease. Symptoms of heart disease completely depend on the infected location.
Some researchers suggested that by making a change in lifestyle accompanied by moderate physical activity such as walking, the risk of heart disease can be prevented.
The American College of Cardiology wrote in the article of Heart Disease: Lifestyle Changes to Lower Risk. "Start slowly, and go at a pace you can manage. Try to do at least 2½ hours of moderate exercise a week. One way to do this is to be active 30 minutes a day, at least 5 days a week".
"Healthy eating starts with learning new ways to eat, such as adding more fresh fruits, vegetables, and whole grains and cutting back on foods that have a lot of saturated fat, sodium, and sugar"
"Getting active and eating a healthy diet can help you lose extra weight and quit smoking"
Finally, the article continued, "Even though you are taking medicine, it is always important to make lifestyle changes that keep your heart and your body healthy".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae, native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Finding a natural ingredient for the treatment of cardiovascular diseases has been a dream of many scientists. Researchers at the joint study led by the IRCCS San Raffaele Pisana, examined the effects of vegetables, including artichoke on CVD.
The joint study included a total of 38 subjects at risk of CVD. After, a week of the run-in period, participants were randomly assigned to one of the following 4-week interventions: low vegetable consumption (800 g of vegetables/week) or high vegetable consumption (4200 g of vegetables/week).
According to the assays that record immunological, and antioxidant markers, leukocyte and lymphocyte expression of the gut-homing β7 integrin, there were no significant changes detected in clinical, immunological, and antioxidant markers in biological samples, except for an increase in white blood cell count for the low vegetable consumption group.
Immune system's innate and adaptive immune responses play an essential role in the development and progression of cardiovascular diseases by inhibiting the pro-inflammatory expression.
Vegetable consumption group exerts a CVD protective effect in modulating markers of immune function and antioxidant status in patients with CVD. In healthy individuals, intake of vegetables does not induce a change of both antioxidant and inflammatory markers associated with immune function, particularly in nonsmoking men.
These results strongly suggested that vegetables modulate the function of the immune system according to the needs of the body.
In other to reveal more information about artichoke anti CVD activity, Dr. Rondanelli M and colleagues at the University of Pavia investigated the artichoke extracts on the cardiovascular disease on both animals and man.
Injection of artichoke not only reduced the levels of cholesterol in the bloodstream through its hypolipidemic activity but also inhibited the expression of high blood glucose and free radicals through the antioxidant and hypoglycemic activity.
The results indicated artichoke reduced the risk and progression of cardiovascular disease by improving the production of antioxidant enzymes against oxidative stress in the initiation of low-grade inflammation, a hallmark of CVD.
Futhermore, artichoke also decreases the levels of blood cholesterol and glucose, the cluster conditions associated with the risk CVD, epidemiologically.
Taken altogether, artichoke which processes anti cardiovascular diseases activity through several mechanisms may be considered a functional remedy for the prevention and treatment of cardiovascular diseases, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases by Peluso I1, Raguzzini A1, Catasta G1, Cammisotto V1, Perrone A1, Tomino C2, Toti E1, Serafini M. (Hindawi)
(2) Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action by Rondanelli M1, Monteferrario F, Perna S, Faliva MA, Opizzi A. (PubMed)
(3) Heart Disease: Lifestyle Changes to Lower Risk by The American College of Cardiology
Tuesday, March 19, 2019
Localized Honey, the Best for the Treatment of Allergies with No Side Effects, According to Studies
Scientists may have found a natural alternative for the treatment of allergies, according to studies.
Allergies are a faulty reaction of the immune systematic responses against harmful substances that enter the body.
Symptoms and diseases associated with allergy include sinus swelling, seasonal and returning allergies, hay fever and nasal allergies.
Believe or not, Penicillin, antibiotic medicine is the most common allergy trigger in drug allergies. 10 percent of people are allergic after using the medicine.
According to the statistics, in the US, approximately, more than 50 million Americans have experienced various types of allergies each year and 15 million Americans have food allergies, including 5.9 million children under age 18.
In other words, 1 in 13 children suffers from a food allergy. About 30 percent of children with food allergies are allergic to more than one food.
The findings strongly suggested that foods are the most common and major cause of the allergic onset.
Dr. Ruchi S. Gupta and colleagues in the allergic team in examining the food allergies in children wrote, "Overall, estimated current FA prevalence was 7.6%,.The most prevalent allergens were peanut (2.2%), milk (1.9%), shellfish (1.3%), and tree nut (1.2%)".
And, "Among food-allergic children, 42.3% reported ≥1 severe FA and 39.9% reported multiple FA. Furthermore, 19.0% reported ≥1 FA-related emergency department visit in the previous year and 42.0% reported ≥1-lifetime FA-related emergency department visit, whereas 40.7% had a current epinephrine autoinjector prescription.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural compound for the treatment of allergies examined the honey effects in the treatment of allergic rhinitis (AR).
The prospective randomized placebo-controlled study included 40 AR patients divided equally into a case group and a control group. All the subjects received a daily dose of 10 mg of loratadine for 4 weeks.
The case group then ingested 1 g/kg body weight of honey daily in separate doses for the 4-week period. The control group ingested the same dose of honey-flavored corn syrup as a placebo.
According to the AR symptoms scored at the start, week 4, and week 8 of the study, at week 4, both groups showed progressive improvement in the symptoms, however, at week 8, only the case group showed continuous improvement in the symptom score.
The ingested honey group showed a significant improvement in individual AR symptoms after week 8 and the efficacy in reducing the symptoms persisted for a month after the cessation of the honey treatment.
The results suggested that honey processed certain chemical compounds that were not found in the corn syrup for the treatment of AR.
Some researchers suggested that long-term intake of raw honey can help to ameliorate allergy symptoms by regularly exposing to pollen, similarly to the allergy injection in desensitizing pollen-program.
If this result is true then only local honey can process the anti-AR symptoms compared to honey unlocalized pollen.
Taken altogether, honey may be considered a functional remedy for the prevention and treatment of AR symptoms, regardless of the types of honey, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East coast of Peninsular Malaysia by Asha'ari ZA1, Ahmad MZ, Jihan WS, Che CM, Leman I. (PubMed)
(2) Will honey relieve my seasonal allergies? by Allergists
(3) The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States by Ruchi S. Gupta, Christopher M. Warren, Bridget M. Smith, Jesse A. Blumenstock, Jialing Jiang, Matthew M. Davis, Kari C. Nadeau. (APP News and Journals)
Allergies are a faulty reaction of the immune systematic responses against harmful substances that enter the body.
Symptoms and diseases associated with allergy include sinus swelling, seasonal and returning allergies, hay fever and nasal allergies.
Believe or not, Penicillin, antibiotic medicine is the most common allergy trigger in drug allergies. 10 percent of people are allergic after using the medicine.
According to the statistics, in the US, approximately, more than 50 million Americans have experienced various types of allergies each year and 15 million Americans have food allergies, including 5.9 million children under age 18.
In other words, 1 in 13 children suffers from a food allergy. About 30 percent of children with food allergies are allergic to more than one food.
The findings strongly suggested that foods are the most common and major cause of the allergic onset.
Dr. Ruchi S. Gupta and colleagues in the allergic team in examining the food allergies in children wrote, "Overall, estimated current FA prevalence was 7.6%,.The most prevalent allergens were peanut (2.2%), milk (1.9%), shellfish (1.3%), and tree nut (1.2%)".
And, "Among food-allergic children, 42.3% reported ≥1 severe FA and 39.9% reported multiple FA. Furthermore, 19.0% reported ≥1 FA-related emergency department visit in the previous year and 42.0% reported ≥1-lifetime FA-related emergency department visit, whereas 40.7% had a current epinephrine autoinjector prescription.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural compound for the treatment of allergies examined the honey effects in the treatment of allergic rhinitis (AR).
The prospective randomized placebo-controlled study included 40 AR patients divided equally into a case group and a control group. All the subjects received a daily dose of 10 mg of loratadine for 4 weeks.
The case group then ingested 1 g/kg body weight of honey daily in separate doses for the 4-week period. The control group ingested the same dose of honey-flavored corn syrup as a placebo.
According to the AR symptoms scored at the start, week 4, and week 8 of the study, at week 4, both groups showed progressive improvement in the symptoms, however, at week 8, only the case group showed continuous improvement in the symptom score.
The ingested honey group showed a significant improvement in individual AR symptoms after week 8 and the efficacy in reducing the symptoms persisted for a month after the cessation of the honey treatment.
The results suggested that honey processed certain chemical compounds that were not found in the corn syrup for the treatment of AR.
Some researchers suggested that long-term intake of raw honey can help to ameliorate allergy symptoms by regularly exposing to pollen, similarly to the allergy injection in desensitizing pollen-program.
If this result is true then only local honey can process the anti-AR symptoms compared to honey unlocalized pollen.
Taken altogether, honey may be considered a functional remedy for the prevention and treatment of AR symptoms, regardless of the types of honey, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East coast of Peninsular Malaysia by Asha'ari ZA1, Ahmad MZ, Jihan WS, Che CM, Leman I. (PubMed)
(2) Will honey relieve my seasonal allergies? by Allergists
(3) The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States by Ruchi S. Gupta, Christopher M. Warren, Bridget M. Smith, Jesse A. Blumenstock, Jialing Jiang, Matthew M. Davis, Kari C. Nadeau. (APP News and Journals)
Sinigrin May Be The Potential Anti Atherosclerosis Chemical Compound, According to Studies
Sinigrin may be used as a bioactive ingredient for the prevention and treatment of atherosclerosis, according to studies.
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, unhealthy diet, family history of heart disease and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol make up a big part in the plaque, an unhealthy diet with a high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.
In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.
Dr. Meifang Wang, the lead researcher in the study of "Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice" said, "....lowered circulating IGF-1 increases atherosclerosis progression in atherosclerosis-prone apolipoprotein E-deficient mice (ApoE−/−) while increased circulating IGF-1 downregulates vascular pro-inflammatory cytokine gene expression, reduces systemic and vascular oxidant stress, vascular cytokine expression, and decreases atherosclerosis progression".
And, "the pro-inflammatory phenotype that is enhanced by WD in ApoE−/− mice is further enhanced by specific IGF1R deficiency in monocytes/macrophages, and may consequently increase atherosclerosis progression".
The results suggested that the Western diet-induced atherosclerosis progression through the increase of production of pro-inflammatory cytokines and decrease of the function of insulin-like growth factor-1 (IGF-1) as a mediator of anabolic responses in many cells and tissues.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on finding a natural bioactive compound for the treatment of atherosclerosis examined the effect of sinigrin against plaque accumulation on the arterial walls.
On atherosclerosis in ApoE-/- mice, injection sinigrin exerted a significant effect in the inhibition of the serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines associated with plaque accumulated on the wall of the arteries.
Furthermore, oral administration of sinigrin attenuated the mRNA expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), which form a part of immunoglobulin superfamily in inflammatory and immune responses.
Moreover, injection also reduced the expression of genes C-C motif chemokine ligand 2 (CCL2), and CCL5 on aorta tissues associated with the risk of atherosclerosis.
The expression of low-density lipoprotein was also reduced by the injection of sinigrin observed by some keys regulators of cholesterol such as sterol regulatory element-binding protein-2 (SREBP-2).
Interestingly, increased the concentration of sinigrin at the dose up to 100 μg/ml also significantly suppressed the levels of Tumor necrosis factor (TNF-α) and nuclear translocation of NF-κB, cell signaling protein (cytokine) involved in systemic inflammation.
Additionally, at a contraction ut to 100 μg/ml, sinigrin inhibited the c-Jun-NH (2)-terminal kinase (JNK) signaling pathway which plays a critical role in regulating cellular differentiation.
The findings strongly suggested that sinigrin inhibited the onset of atherosclerosis through lowering the low-density lipoproteins and mechanisms associated with inflammatory induction of plaque accumulation on the arterial wall.
Dr. Jang YJ, the lead scientist wrote, "sinigrin decreases the TNF-α-stimulated VCAM-1 expression through the suppression of NF-κB and MAP kinases signaling pathways, Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis".
Taken altogether, sinigrin may be considered a supplement for the prevention and combined with the primary therapy for the treatment of atherosclerosis, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice by Meifang Wang, Yusuke Higashi, Derek Wang, Ronald Korthuis, and Patrice Delafontaine. (FASEB Journal)
Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.
Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.
According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.
Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, unhealthy diet, family history of heart disease and physical inactivity, particularly smoking.
Some researchers suggested that since cholesterol make up a big part in the plaque, an unhealthy diet with a high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.
In other words, the Western diet is one of the major culprits that cause the majority of cases of atherosclerosis.
Dr. Meifang Wang, the lead researcher in the study of "Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice" said, "....lowered circulating IGF-1 increases atherosclerosis progression in atherosclerosis-prone apolipoprotein E-deficient mice (ApoE−/−) while increased circulating IGF-1 downregulates vascular pro-inflammatory cytokine gene expression, reduces systemic and vascular oxidant stress, vascular cytokine expression, and decreases atherosclerosis progression".
And, "the pro-inflammatory phenotype that is enhanced by WD in ApoE−/− mice is further enhanced by specific IGF1R deficiency in monocytes/macrophages, and may consequently increase atherosclerosis progression".
The results suggested that the Western diet-induced atherosclerosis progression through the increase of production of pro-inflammatory cytokines and decrease of the function of insulin-like growth factor-1 (IGF-1) as a mediator of anabolic responses in many cells and tissues.
Sinigrin is a phytochemical glucosinolate, belonging to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on finding a natural bioactive compound for the treatment of atherosclerosis examined the effect of sinigrin against plaque accumulation on the arterial walls.
On atherosclerosis in ApoE-/- mice, injection sinigrin exerted a significant effect in the inhibition of the serum concentrations of lactate dehydrogenase (LDH), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), calcium (Ca2+), and pro-inflammatory cytokines associated with plaque accumulated on the wall of the arteries.
Furthermore, oral administration of sinigrin attenuated the mRNA expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), which form a part of immunoglobulin superfamily in inflammatory and immune responses.
Moreover, injection also reduced the expression of genes C-C motif chemokine ligand 2 (CCL2), and CCL5 on aorta tissues associated with the risk of atherosclerosis.
The expression of low-density lipoprotein was also reduced by the injection of sinigrin observed by some keys regulators of cholesterol such as sterol regulatory element-binding protein-2 (SREBP-2).
Interestingly, increased the concentration of sinigrin at the dose up to 100 μg/ml also significantly suppressed the levels of Tumor necrosis factor (TNF-α) and nuclear translocation of NF-κB, cell signaling protein (cytokine) involved in systemic inflammation.
Additionally, at a contraction ut to 100 μg/ml, sinigrin inhibited the c-Jun-NH (2)-terminal kinase (JNK) signaling pathway which plays a critical role in regulating cellular differentiation.
The findings strongly suggested that sinigrin inhibited the onset of atherosclerosis through lowering the low-density lipoproteins and mechanisms associated with inflammatory induction of plaque accumulation on the arterial wall.
Dr. Jang YJ, the lead scientist wrote, "sinigrin decreases the TNF-α-stimulated VCAM-1 expression through the suppression of NF-κB and MAP kinases signaling pathways, Overall, sinigrin has the potential to be used in reducing the risks of atherosclerosis".
Taken altogether, sinigrin may be considered a supplement for the prevention and combined with the primary therapy for the treatment of atherosclerosis, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression by Jang YJ1, Park B1, Lee HW1, Park HJ1, Koo HJ2, Kim BO3, Sohn EH4, Um SH5, Pyo S. (PubMed)
(2) Western Diet Increases Inflammatory Responses and Atherosclerosis Progression via IGF-1 Receptor in ApoE-Deficient Mice by Meifang Wang, Yusuke Higashi, Derek Wang, Ronald Korthuis, and Patrice Delafontaine. (FASEB Journal)
Monday, March 18, 2019
Herbal Calendula, the Potent Anti Edema Functional Remedy
Herbal Calendula may have a potential effect in reducing risk and treatment of edema, some scientists suggested.
Edema is a condition characterized by an abnormal accumulation of fluid in certain tissues within the body due to injury or inflammation.
In most cases, edema occurs under the surfaces of the skin in the leg and ankle. However, fluids can also be accumulated in the lungs (pulmonary edema).
Without the assistance of diagnosis, researchers can not pinpoint the exact causes of edema.
There are numbers of risk factor associated with the onset of the swellings, such as low levels of albumin that keeps the blood in the vessels, allergic reaction, blood clots. Some medical conditions such as congestive heart failure, kidney diseases and long-term intake medicine such as NSAIDs and calcium channel blockers also increased the risk of edema.
Some researchers suggested that under normal conditions, medicine that removes excess fluid and reduces intake salt can be effective. However, if the condition of edema is caused by underlying disease, separated medicine treatment may be required.
If you are experiencing symptoms of heavy leg and ankle and shortness of breath, please check with your doctor to rule out the edema possibility.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Chemical ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
In the study to examine the anti-inflammatory effect of Calendula officinalis flower extract against paw edema, researchers at the Amala Cancer Research Centre, launched an investigation in the paw edema of animals induced by carrageenan and dextran.
Oral injection of 250 and 500 mg/kg body weight of Calendula extract exerted a significant inhibition (50.6 and 65.9% respectively) in paw edema of animals by 41.9% in the carrageenan group and 42.4% in the dextran group, respectively through the anti-inflammatory activity.
In chronic inflammatory model induced by injection of formalin, administration of 250 and 500 mg/kg body weight of Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls.
Further examination also found that proinflammatory cytokines activated by macrophage of the immune system in the response to infection are also reduced significantly.
Other proinflammatory proteins such as IL- 1beta, IL-6, TNF-alpha and IFN-gamma and acute phase protein, C- reactive protein (CRP) in edema mice produced by LPS injection were inhibited significantly by the extracts in different doses.
These results suggested that herbal Calendula inhibits edema caused by inflammation through its anti-inflammatory expression.
Additionally, in the study to reaffirm the efficacy of Calendula anti-inflammation against the progression of edema, researchers at the niversità di Trento conducted a differentiation on the anti-inflammatory chemical constituents of the herb.
13 out of 15 terpenoids from Calendula were found to process topical anti-inflammatory activities with respect to the inhibition of croton oil-induced ear edema in the mouse.
Three derivatives of Rings A, D, and E of faradiol, the C(16) benzyl ether 15, the C(30) aldehyde 24, and the C(30) primary alcohol 25 isolated from the herb also showed a significantly improved anti-inflammatory potency.
Taken altogether, herbal Calendula with the abundant anti-inflammatory bioactive compounds may have a potential effect in the prevention and treatment of inflammatory edema.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Phytochemical Constituents and PharmacologicalActivities of Calendula officinalis Linn (Asteraceae): A Review by BP Muley, SS Khadabadi and NB Banarase (Tropical Journal of Pharmaceutical Research)
(2)Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action by Preethi KC, Kuttan G, Kuttan R.(PubMed)
(3) Improved anti-inflammatory activity of three new terpenoids derived, by systematic chemical modifications, from the abundant triterpenes of the flowery plant Calendula officinalis by Neukirch H, D'Ambrosio M, Sosa S, Altinier G, Della Loggia R, Guerriero A.(PubMed)
Edema is a condition characterized by an abnormal accumulation of fluid in certain tissues within the body due to injury or inflammation.
In most cases, edema occurs under the surfaces of the skin in the leg and ankle. However, fluids can also be accumulated in the lungs (pulmonary edema).
Without the assistance of diagnosis, researchers can not pinpoint the exact causes of edema.
There are numbers of risk factor associated with the onset of the swellings, such as low levels of albumin that keeps the blood in the vessels, allergic reaction, blood clots. Some medical conditions such as congestive heart failure, kidney diseases and long-term intake medicine such as NSAIDs and calcium channel blockers also increased the risk of edema.
Some researchers suggested that under normal conditions, medicine that removes excess fluid and reduces intake salt can be effective. However, if the condition of edema is caused by underlying disease, separated medicine treatment may be required.
If you are experiencing symptoms of heavy leg and ankle and shortness of breath, please check with your doctor to rule out the edema possibility.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Chemical ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
In the study to examine the anti-inflammatory effect of Calendula officinalis flower extract against paw edema, researchers at the Amala Cancer Research Centre, launched an investigation in the paw edema of animals induced by carrageenan and dextran.
Oral injection of 250 and 500 mg/kg body weight of Calendula extract exerted a significant inhibition (50.6 and 65.9% respectively) in paw edema of animals by 41.9% in the carrageenan group and 42.4% in the dextran group, respectively through the anti-inflammatory activity.
In chronic inflammatory model induced by injection of formalin, administration of 250 and 500 mg/kg body weight of Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls.
Further examination also found that proinflammatory cytokines activated by macrophage of the immune system in the response to infection are also reduced significantly.
Other proinflammatory proteins such as IL- 1beta, IL-6, TNF-alpha and IFN-gamma and acute phase protein, C- reactive protein (CRP) in edema mice produced by LPS injection were inhibited significantly by the extracts in different doses.
These results suggested that herbal Calendula inhibits edema caused by inflammation through its anti-inflammatory expression.
Additionally, in the study to reaffirm the efficacy of Calendula anti-inflammation against the progression of edema, researchers at the niversità di Trento conducted a differentiation on the anti-inflammatory chemical constituents of the herb.
13 out of 15 terpenoids from Calendula were found to process topical anti-inflammatory activities with respect to the inhibition of croton oil-induced ear edema in the mouse.
Three derivatives of Rings A, D, and E of faradiol, the C(16) benzyl ether 15, the C(30) aldehyde 24, and the C(30) primary alcohol 25 isolated from the herb also showed a significantly improved anti-inflammatory potency.
Taken altogether, herbal Calendula with the abundant anti-inflammatory bioactive compounds may have a potential effect in the prevention and treatment of inflammatory edema.
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Phytochemical Constituents and PharmacologicalActivities of Calendula officinalis Linn (Asteraceae): A Review by BP Muley, SS Khadabadi and NB Banarase (Tropical Journal of Pharmaceutical Research)
(2)Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action by Preethi KC, Kuttan G, Kuttan R.(PubMed)
(3) Improved anti-inflammatory activity of three new terpenoids derived, by systematic chemical modifications, from the abundant triterpenes of the flowery plant Calendula officinalis by Neukirch H, D'Ambrosio M, Sosa S, Altinier G, Della Loggia R, Guerriero A.(PubMed)
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