Bacterias are a class of microorganism consisted of a single cell with a simple internal structure with a number of different shapes.
Not all bacterias are harmful to human. Some are essential to human life, with benefits related to improve the digestive function, prevent overexpression of harmful disease-causing bacteria, and the synthesis of essential nutrients and vitamins.
Believe or not, human gut contains over 10 trillions of bacterias including at least 1000 different species of known bacteria with more than 3 million genes.
In a healthy individual, the levels of microorganisms in the gut are balanced.
The gut microbiota plays a critical role in breaking down foods that stomach and small intestines cannot digest, stimulating the production of vitamin K and D, protecting the intestinal against damage caused by bad bacteria and increasing the immune functioning.
Bacterias that cause disease are called pathogenic microorganisms.
Epidemiological studies suggested that Mycobacterium tuberculosis bacteria is one of the bacteria that causes tuberculosis, killing over 2 million people a year, mostly in sub-Saharan Africa.
Other pathogenic bacterias include Streptococcus and Pseudomonas, and Shigella, Campylobacter, and Salmonella.
According to the statistics, pathogenic bacterial infection is a leading cause of death of infants in developing countries.
On the finding a bioactive ingredient with antibacterial activity, researchers examined allyl isothiocyanate (AIT) is derived from the glucosinolate sinigrin in E. coli O157:H7 numbers in food products.
Injection of AIT showed a greater antimicrobial activity at low pH values. In other words, at pH 4.5 and 5.5 the MIC was 25 microL/L, while at pH 8.5, 500 microL/L was required to inhibit bacterial growth.
Furthermore, bacterial decomposition was found at the highest rate in water at 37 degrees C.
Moreover, in bacterial enzymes (the thioredoxin reductase and acetate kinase), AIT at 10 to 100 microL/L was able to significantly inhibit both enzymes, but only 1 microL/L was needed to decrease the activity of thioredoxin reductase.
Interestingly, in a Nanocomposite carboxymethyl cellulose films tested on Escherichia coli O157:H7-containing sinigrin (SNG) prepared by stirring 2% (w/v) carboxymethyl cellulose (CMC) and 2% (w/v) glycerol (as a plasticizer) in distilled water with or without SNG (an antimicrobial precursor) as a 99% pure reagent (pSNG) or as a crude extract (cSNG), researchers found that
* In beef pieces measuring 6 × 5 × 2 cm(3) (L × W × H) were dipped in an E. coli O157:H7 broth suspension containing >8 log10 CFU ml(-1) and were drained for 3 min over a sterile cloth, the CMC and NCMC films without SNG were not antimicrobial against E. coli O157:H7; however, NCMC and CMC films with SNG were highly antimicrobial.
* After 5 days at 8°C, E. coli O157:H7 was reduced more than 4 log10 by the NCMC•pSNG film.
* The reduction remained almost the same until 18 days at 8°C when E. coli O157:H7 was reduced >5 log10 CFU g(-1) meat.
The findings strongly support the use of sinigrin for food storage against bacteria.
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the treatment of bacterial infection, pending to the confirmation of large sample size and multicenter human study.
However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Source
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
Sunday, March 31, 2019
3,3'-Diindolylmethane, the Natural Treatment for Arthritis
Arthritis is a group of diseases associated with the inflammation of the joints. According to the epidemiological studies osteoarthritis (OA) and rheumatoid arthritis (RA) are 2 most common types of arthritis.
According to the information provided by the arthritis foundation, arthritis affects over 54 million people in adults of which diagnosed by doctors. Osteoarthritis is the most prevalent type in the US, affecting 31 million Americans.
Depending on types and the location affected, arthritis can be classified into over 100 conditions, but the most common types of arthritis include
* Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.
* Osteoarthritis (OA), is a condition caused by the wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.
* Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.
* Polymyalgia arthritis is a condition of inflammatory rheumatic disease induced pain, stiffness, and tenderness in large muscles, including muscles shoulders and pelvic girdle.
* Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
As of today, there is no cure for arthritis, medications used in conventional medicine are to reduce pain, and symptoms and improve quality of life for patients to carry out daily activity.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency to discover a natural compound for the treatment of diseases associated with osteoclastogenesis, researchers investigated the therapeutic efficacies of DIM on experimental arthritis.
The study included a rat model of adjuvant-induced arthritis (AIA), with daily AIA paw swelling.
According to the clinical and histologic indices of inflammation and tissue damage, administration of DIM attenuated AIA in animal models.
Furthermore, DIM also reduced the expression of several inflammatory cytokines, associated with the onset of arthritis. However, the anti-inflammatory function of DIM could not prevent the development of arthritis.
Moreover, in the differentiation of the DIM effect on activation-induced cytokine, researchers found that the bioactive compound effectively inhibits the expression of RANKL, leading to the blockade of osteoclastogenesis and consequently an alleviation of experimental arthritis.
Where Receptor activator of nuclear factor kappa-Β ligand (RANKL) is a protein involved the activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor.
Dr. the lead researcher wrote, "DIM has shown anti-arthritis activity in animal models via inhibiting the expression of RANKL, and thus may offer potential treatments for arthritis and associated disorders".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of arthritis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis by Dong L1, Xia S, Gao F, Zhang D, Chen J, Zhang J. (PubMed)
According to the information provided by the arthritis foundation, arthritis affects over 54 million people in adults of which diagnosed by doctors. Osteoarthritis is the most prevalent type in the US, affecting 31 million Americans.
Depending on types and the location affected, arthritis can be classified into over 100 conditions, but the most common types of arthritis include
* Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.
* Osteoarthritis (OA), is a condition caused by the wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.
* Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.
* Polymyalgia arthritis is a condition of inflammatory rheumatic disease induced pain, stiffness, and tenderness in large muscles, including muscles shoulders and pelvic girdle.
* Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
As of today, there is no cure for arthritis, medications used in conventional medicine are to reduce pain, and symptoms and improve quality of life for patients to carry out daily activity.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency to discover a natural compound for the treatment of diseases associated with osteoclastogenesis, researchers investigated the therapeutic efficacies of DIM on experimental arthritis.
The study included a rat model of adjuvant-induced arthritis (AIA), with daily AIA paw swelling.
According to the clinical and histologic indices of inflammation and tissue damage, administration of DIM attenuated AIA in animal models.
Furthermore, DIM also reduced the expression of several inflammatory cytokines, associated with the onset of arthritis. However, the anti-inflammatory function of DIM could not prevent the development of arthritis.
Moreover, in the differentiation of the DIM effect on activation-induced cytokine, researchers found that the bioactive compound effectively inhibits the expression of RANKL, leading to the blockade of osteoclastogenesis and consequently an alleviation of experimental arthritis.
Where Receptor activator of nuclear factor kappa-Β ligand (RANKL) is a protein involved the activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor.
Dr. the lead researcher wrote, "DIM has shown anti-arthritis activity in animal models via inhibiting the expression of RANKL, and thus may offer potential treatments for arthritis and associated disorders".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of arthritis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis by Dong L1, Xia S, Gao F, Zhang D, Chen J, Zhang J. (PubMed)
Saturday, March 30, 2019
Phytochemical Piperine, the Anti Metabolic Dysfunctions in Obese Patients
Piperine may be considered a natural ingredient for the treatment of metabolic dysfunction in obese patients, some scientists suggested.
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
Obesity is a medical condition characterized by excess body fat accumulated in the body over time.
While overweight is a condition of excess body weight relative to the height.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of the American population is either overweight or obese, a leading cause of metabolic dysfunction.
In other words, obesity is a metabolic disorder that predisposes patients to numerous diseases which not only cause a financial burden to the health care system but also increase the reduction of quality of life of the patients.
A metabolic dysfunction is caused either by the abnormal chemical reactions or disruption of chemical production in the body, altering the normal metabolic process.
Some researchers suggested that obesity's metabolic dysfunction may be a result of the liver or pancreas do not function properly due to fat accumulated in the organs.
There is no coincidence that the widespread of obesity over the past several decades are correlated to the promotion of the Western diet. Some researchers firmly suggested that diet rich in saturated and trans fat, red meat and processed foods and less in fruits and vegetables and whole grain is associated with the onset of obesity.
Dr. Bortolin RC, the lead scientists in the study to examine the metabolic parameters and gut microbiota changes in rat fed with the Western diet suggested: "diet, and not the obese state, was the major driving force behind gut microbiota changes" and "WD-fed rats developed obesity and obesity-related comorbidities independent of major alterations in gut microbiota composition (dysbiosis), whereas CAF-fed rats developed the greatest dysbiosis independent of obesity".
The result clearly stated that long-term intake of the Western diet induces metabolic syndrome and obesity. In other words, Obesity is not the cause of metabolic dysfunction.
On finding a natural ingredient or whole food for the prevention and treatment of widespread obesity-induced metabolic dysfunctions in the Western world, researchers examine the antimetabolic phytochemical Piperine isolated from the black pepper.
The randomized, double-blind, placebo-controlled, 8-week trial included the assessment of the efficacy of metabolic changes versus a placebo.
In a total of 86 overweight subjects selected to the study, 41 patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m(2)) were assigned to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group.
At the end of 8 weeks, the supplement group showed a decrease of levels of a hormone produced by adipose cells that regulates energy balance by inhibiting hunger. High levels of leptin hormone is an indication of leptin resistance, found in overweight and obese patients.
The levels of a hormone associated with the stimulated appetite increased food intake and promoted fat storage also decreased in the supplement group. Hormone ghrelin is found abundantly in overweight and obese subjects.
Furthermore, the supplement group also showed a decrease of inflammation observed by the levels of C-reactive protein and an increased resting energy expenditure significantly, compared to placebo.
Compared to the decreased significantly levels of adiponectin in the placebo, the supplement group also showed an increase in the hormone protein that regulates glucose levels as well as fatty acid breakdown.
These results suggested that the supplement group demonstrates a greater change of metabolic dysfunction compared to the placebo.
In other words, introducing piperine into the overweight and obese diet might be useful for the treatment of obesity-related inflammatory metabolic dysfunctions.
Additionally, in order to understand the effect of piperine on overweight and obese insulin resistance, researchers evaluated the bioactive chemical activity in mice feeding a high-fat diet (HFD) for 13 weeks.
Before injecting the mice with piperine, researchers found that mice fed with high-fat-diet display elevated plasma concentrations of insulin and glucose and hepatic lipid levels.
Administration of piperine (50 mg/kg body weight) only normalized the concentrations of insulin and glucose and hepatic lipid levels but also increased the levels of adiponectin and inhibited the protein which plays an important role in mediating lipogenesis, fatty acid oxidation and insulin signaling in the livers of mice.
In gene observation, piperine injection also increased the expression of carnitine palmitoyltransferase 1 (CPT1) gene involved the regulation of fatty acid oxidation in the liver, an indication of resist weight gain.
Dr. Choi S, the lead researcher suggested, piperine significantly decreased insulin resistance in mice fed with high-fat diet by increasing the levels of adiponectin and activating the pathway associated with fatty acid oxidation.
Taken altogether, piperine may be considered a bioactive compound for the protection of overweight and obese against the inflammatory and metabolic dysfunctions and weight gain without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects by Rondanelli M, Opizzi A, Perna S, Faliva M, Solerte SB, Fioravanti M, Klersy C, Cava E, Paolini M, Scavone L, Ceccarelli P, Castellaneta E, Savina C, Donini LM. (PubMed)
(2) Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice by Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T.(PubMed)
(3) Piperine, an active principle from Piper nigrum, modulates hormonal and apolipoprotein profiles in hyperlipidemic rats by Vijayakumar RS, Nalini N.(PubMed)(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)
Ginger, The Potent Anti Obesity Functional Food
Ginger may be considered a functional food for the prevention and treatment of obesity without inducing side effects, some scientists found.
Obesity is a medical disease associated with extreme overweight.
In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
What causes obesity? Some researchers suggested that too much calories consumption and lack of physical exercise are the 2 main causes of obesity in once healthy individuals.
Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of American and the promotion of the Western diet in the past few decades.
Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern".
And, " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet, or even a lack of essential vitamins and minerals".
These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.
Application of ginger in vivo and vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,
Diet-induced obesity was attenuated in C57BL/6J mice treated with dietary ginger extract (GE)also exhibited an increase in energy expenditure.
GE also exerted an anti-obesity effect through promoting the increased the number of Types I muscle fibers, running endurance capacity and upregulated PPARδ-targeted gene expression in skeletal muscle
Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.
After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".
Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers at the showed that gingerenone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).
In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.
Dr.Suk S the lead authors said at the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".
Taken altogether, ginger processed abundant bioactive compounds may be considered a functional food in stimulating weight loss in the obese subjects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)
Obesity is a medical disease associated with extreme overweight.
In other words, obesity is the accumulation of excess fat to the extent that it may have an adverse effect on patient health.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, and a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
What causes obesity? Some researchers suggested that too much calories consumption and lack of physical exercise are the 2 main causes of obesity in once healthy individuals.
Some scientists indicated, there is no coincidence but a close correlation between the onset of obesity in a large percentage of American and the promotion of the Western diet in the past few decades.
Dr. Bortolin RC, the lead researcher in the obese team in the joint study led by the Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul (UFRGS in the examine the new animal diet based on human Western diet said, "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public health concern".
And, " diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet, or even a lack of essential vitamins and minerals".
These results strongly suggested that the Western diet alters the gut microbiota composition (dysbiosis) probably due to substances found in the Western diet foods, that are not found in other diets, compared to the group treated with HFD developed the greatest dysbiosis independent of obesity
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding natural ingredients or whole food for the treatment of obesity researchers examine the traditional use of ginger in an animal model.
Application of ginger in vivo and vitro demonstrated a potential anti-obesity effect in regulating the PPARγ signaling pathway in adipocytes in the initiation of obesity,
Diet-induced obesity was attenuated in C57BL/6J mice treated with dietary ginger extract (GE)also exhibited an increase in energy expenditure.
GE also exerted an anti-obesity effect through promoting the increased the number of Types I muscle fibers, running endurance capacity and upregulated PPARδ-targeted gene expression in skeletal muscle
Furthermore, the cellular respiration assay also revealed that pretreating cultured skeletal muscle myotubes with GE increased palmitate-induced oxygen consumption rate, which suggested an increase in cellular fatty acid catabolism, another anti-obesity activity.
After taking into account co and confounders, researchers said, "6-Shogaol and 6-gingerol (the ginger bioactive constituents)may be responsible for the regulatory effects of dietary ginger on PPARδ signaling".
Moreover, additional investigation of ginger exerts protective on obesity and its complications, researchers at the showed that gingerenone A, a bioactive compound isolated from ginger had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components at a single concentration (40 μM).
In vitro data, GA attenuates diet-induced obesity (DIO) by reducing fat mass in mice, accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in stimulating weight loss, in vitro and in vivo.
Dr.Suk S the lead authors said at the final report, " GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation".
Taken altogether, ginger processed abundant bioactive compounds may be considered a functional food in stimulating weight loss in the obese subjects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review by Wang J1,2, Ke W1, Bao R1, Hu X1,2, Chen F. (PubMed)
(2) Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway by Misawa K1, Hashizume K2, Yamamoto M3, Minegishi Y4, Hase T5, Shimotoyodome A. (PubMed)
(3) Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice by Suk S1, Kwon GT2, Lee E1, Jang WJ1, Yang H1, Kim JH3, Thimmegowda NR4, Chung MY1, Kwon JY5, Yang S1, Kim JK1,5, Park JHY2,3, Lee KW. (PubMed)
(4) A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)
Friday, March 29, 2019
Manuka Honey, the Best Anti-influenza Functional Food
Honey may have a profound effect in reducing the risk and treatment of influenza, some scientists suggested.
Influenza, also known as the flu, is an infectious disease caused by an influenza virus.
There are 3 types of flu influenza: A, B, and C. the influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of general population.
Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.
Healthy individuals who have influenza are usually recovered within one week.
However, people with immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.
Pregnant women and women up to two weeks postpartum due to change of the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.
Some researchers also suggested that obese people are also at a higher risk of the onset of influenza.
Dr. Green WD, the lead author at the University of North Carolina at Chapel Hill suggested that obese individual associated with the impairment of the adaptive immune response at substantial risk of influenza.
The doctor team in the study " Obesity Impairs the Adaptive Immune Response to Influenza Virus" wrote, "Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese".
"Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination".
Most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient and whole food for the prevention and treatment of influenza, researchers at the joint study led by the Nagasaki University the antiviral activities of honey samples were evaluated using MDCK cells.
Application of Manuka honey efficiently inhibited influenza virus replication which is related to its virucidal effects.
Manuka honey at the dose of 3.13 mg/mL also improved the function of zanamivir or oseltamivir by reducing the maximum concentration of effectiveness to nearly 1/1000th for their single use.
Dr.Watanabe K, the lead scientist said, "honey, in general, and particularly Manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.
Moreover, by the re-examining the anti-influenza effect of Luatang honey, researchers suspected that the efficacy may be associated with the presence of the methylglyoxal (MGO), a key component of Manuka honey.
By evaluating the anti-influenza viral activity of MGO and its potential in combination treatments with neuraminidase (NA) inhibitors, researchers found that
* Injection of MGO inhibited influenza virus A/WSN/33 replication 50% inhibitory concentration = 240 ± 190 μM; 50% cytotoxic concentration = 1.4 ± 0.4 mM; selective index (SI) = 5.8, which is related to its virucidal effects.
* MGO exerted a promising activity against various influenza strains.
* MGO increases the effect of NA inhibitors by decreasing the to the ∼1/100(th) of their single usage.
* MGO also demonstrates a synergistic effect with NA inhibitor against the oseltamivir-resistant virus.
Taken altogether, Luatang honey processed bioactive compound methylglyoxal (MGO) may be considered a functional food for the prevention and combined with primary therapy for the treatment of influenza with no side effects, pending to a larger and multi=centers human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3.(PubMed)
(2) In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection by Charyasriwong S1, Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3. (PubMed)
(3) Obesity Impairs the Adaptive Immune Response to Influenza Virus by Green WD1, Beck MA. (PubMed).
Influenza, also known as the flu, is an infectious disease caused by an influenza virus.
There are 3 types of flu influenza: A, B, and C. the influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of general population.
Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.
Healthy individuals who have influenza are usually recovered within one week.
However, people with immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.
Pregnant women and women up to two weeks postpartum due to change of the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.
Some researchers also suggested that obese people are also at a higher risk of the onset of influenza.
Dr. Green WD, the lead author at the University of North Carolina at Chapel Hill suggested that obese individual associated with the impairment of the adaptive immune response at substantial risk of influenza.
The doctor team in the study " Obesity Impairs the Adaptive Immune Response to Influenza Virus" wrote, "Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese".
"Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination".
Most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient and whole food for the prevention and treatment of influenza, researchers at the joint study led by the Nagasaki University the antiviral activities of honey samples were evaluated using MDCK cells.
Application of Manuka honey efficiently inhibited influenza virus replication which is related to its virucidal effects.
Manuka honey at the dose of 3.13 mg/mL also improved the function of zanamivir or oseltamivir by reducing the maximum concentration of effectiveness to nearly 1/1000th for their single use.
Dr.Watanabe K, the lead scientist said, "honey, in general, and particularly Manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.
Moreover, by the re-examining the anti-influenza effect of Luatang honey, researchers suspected that the efficacy may be associated with the presence of the methylglyoxal (MGO), a key component of Manuka honey.
By evaluating the anti-influenza viral activity of MGO and its potential in combination treatments with neuraminidase (NA) inhibitors, researchers found that
* Injection of MGO inhibited influenza virus A/WSN/33 replication 50% inhibitory concentration = 240 ± 190 μM; 50% cytotoxic concentration = 1.4 ± 0.4 mM; selective index (SI) = 5.8, which is related to its virucidal effects.
* MGO exerted a promising activity against various influenza strains.
* MGO increases the effect of NA inhibitors by decreasing the to the ∼1/100(th) of their single usage.
* MGO also demonstrates a synergistic effect with NA inhibitor against the oseltamivir-resistant virus.
Taken altogether, Luatang honey processed bioactive compound methylglyoxal (MGO) may be considered a functional food for the prevention and combined with primary therapy for the treatment of influenza with no side effects, pending to a larger and multi=centers human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3.(PubMed)
(2) In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection by Charyasriwong S1, Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3. (PubMed)
(3) Obesity Impairs the Adaptive Immune Response to Influenza Virus by Green WD1, Beck MA. (PubMed).
Bilberry Balances the Gut Microbiota for Optimal Health, According to Studies
Scientists may have found a natural and herbal remedy for the improvement of digestive gut microbiota for health optimization, according to studies.
Gut microbiota, or gastrointestinal microbiota, the complex community of microorganisms in our digestive tracts plays a critical role in a variety of metabolic functions, including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile.
Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.
In the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, leading to an immune system in inducing the proinflammatory cytokines.
However, the imbalance of digestive gut microbiota has been found to induce a number of diseases, syndromes, and functional aberrations, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of disease such as obesity, and type 2 diabetes.
Imbalanced gut microbiota is found in obese patients, compared to healthy weight individuals.
Dr. Kyle J. Wolf, the lead scientist in the investigation the link of obesity and gut microbiota, wrote, "
In recent years it has been definitively shown that microbiota in the gastrointestinal tract is altered in obese individuals".
And, "Normal humans and mice have 60% to 80% Firmicutes (which are primarily nonculturable, butyrate-producing Clostridium cluster XIVa) and 20% Bacteroidetes (Cytophaga-Flavobacterium-Bacteroides). However, the obese mouse model (ob/ob) had a 50% reduction in Bacteroidetes and an increase in Firmicutes. A similar decrease in Bacteroidetes and increase in Firmicutes is also seen when C57BL/6 mice are fed a high-fat (HF) diet".
The results in the mice model study strongly linked the Western diet and the risk of imbalanced gut microbiota in facilitating the onset of obesity.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient for the improvement of digestive system functioning in the elderly examined the bilberry anthocyanin extract consumption and healthy aging and the effects on intestinal barrier function and digestive enzyme activity.
In the aging rats selected to the study, injection of medium-dose bilberry anthocyanin at 20 mg per kg bw per day) showed to optimizing the intestinal function.
Analyzing the gut microbiota, consumption of bilberry anthocyanin balanced the levels of bacteria in the intestine by increasing the good bacterias such as Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7- and the Lachnospiraceae_NK4A136_group) and decreasing the levels of harmful bacterias, such as Verrucomicrobia and Euryarchaeota.
However. injection of any dose higher than 20 mg per kg displayed the alternation of some intestinally beneficial bacteria in an adverse way.
Furthermore, besides improving the levels of gut microbiota, consumption of bilberry anthocyanin also induced the changes in short-chain fatty acids and the intestinal mucosal barrier, correlatedly.
In other words, the injection of the extract consumption also improved the decreased activity of digestive enzymes in breaking down the proteins into amino acids due to aging.
Dr. Li J, the lead scientist wrote, "Bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".
Moreover, in order to reveal more information about bilberry gut microbiota effects, researchers compared bilberries and cloudberries, the 2 berries on the.intestinal immune responses and gut microbiota.
Injection of bilberry not only reduced the expression of pro-inflammatory cytokines through immunomodulatory activity but also improved the balance of the gut microbiota compared to cloudberries and control group.
Interestingly, cloudberry inhibited and bilberry exhibited the expression of energy metabolism-related genes in the intestinal mucosa.
Additionally, the microbial profiles of cloudberry-fed mice clustered together associated with small adenoma size compared to bilberry group.
The findings suggested that bilberry consumption demonstrated potential digestive health by attenuating of intestinal inflammation, improving microbial profiles, and exhibiting mucosal energy metabolism.
Taken altogether, bilberry processed a high amount bioactive compound may be considered a functional remedy for optimizing the bodily health by balancing the levels of gut microbiota.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X. (PubMed)
(2) Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice by Päivärinta E1, Niku M2, Maukonen J3, Storvik M4, Heiman-Lindh A5, Saarela M6, Pajari AM7, Mutanen M. (PubMed)
(3) Part 1: The Human Gut Microbiome in Health and Disease by Matthew J. Bull, BSc, Ph.D. and Nigel T. Plummer, Ph.D. (PMC)
(4) Gut Microbiota and Obesity by Kyle J. Wolfa and Robin G. Lorenz. (PMC)
Gut microbiota, or gastrointestinal microbiota, the complex community of microorganisms in our digestive tracts plays a critical role in a variety of metabolic functions, including produced vitamins, synthesized all essential and nonessential amino acids, and carried out biotransformation of bile.
Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.
In the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, leading to an immune system in inducing the proinflammatory cytokines.
However, the imbalance of digestive gut microbiota has been found to induce a number of diseases, syndromes, and functional aberrations, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of disease such as obesity, and type 2 diabetes.
Imbalanced gut microbiota is found in obese patients, compared to healthy weight individuals.
Dr. Kyle J. Wolf, the lead scientist in the investigation the link of obesity and gut microbiota, wrote, "
In recent years it has been definitively shown that microbiota in the gastrointestinal tract is altered in obese individuals".
And, "Normal humans and mice have 60% to 80% Firmicutes (which are primarily nonculturable, butyrate-producing Clostridium cluster XIVa) and 20% Bacteroidetes (Cytophaga-Flavobacterium-Bacteroides). However, the obese mouse model (ob/ob) had a 50% reduction in Bacteroidetes and an increase in Firmicutes. A similar decrease in Bacteroidetes and increase in Firmicutes is also seen when C57BL/6 mice are fed a high-fat (HF) diet".
The results in the mice model study strongly linked the Western diet and the risk of imbalanced gut microbiota in facilitating the onset of obesity.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient for the improvement of digestive system functioning in the elderly examined the bilberry anthocyanin extract consumption and healthy aging and the effects on intestinal barrier function and digestive enzyme activity.
In the aging rats selected to the study, injection of medium-dose bilberry anthocyanin at 20 mg per kg bw per day) showed to optimizing the intestinal function.
Analyzing the gut microbiota, consumption of bilberry anthocyanin balanced the levels of bacteria in the intestine by increasing the good bacterias such as Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7- and the Lachnospiraceae_NK4A136_group) and decreasing the levels of harmful bacterias, such as Verrucomicrobia and Euryarchaeota.
However. injection of any dose higher than 20 mg per kg displayed the alternation of some intestinally beneficial bacteria in an adverse way.
Furthermore, besides improving the levels of gut microbiota, consumption of bilberry anthocyanin also induced the changes in short-chain fatty acids and the intestinal mucosal barrier, correlatedly.
In other words, the injection of the extract consumption also improved the decreased activity of digestive enzymes in breaking down the proteins into amino acids due to aging.
Dr. Li J, the lead scientist wrote, "Bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".
Moreover, in order to reveal more information about bilberry gut microbiota effects, researchers compared bilberries and cloudberries, the 2 berries on the.intestinal immune responses and gut microbiota.
Injection of bilberry not only reduced the expression of pro-inflammatory cytokines through immunomodulatory activity but also improved the balance of the gut microbiota compared to cloudberries and control group.
Interestingly, cloudberry inhibited and bilberry exhibited the expression of energy metabolism-related genes in the intestinal mucosa.
Additionally, the microbial profiles of cloudberry-fed mice clustered together associated with small adenoma size compared to bilberry group.
The findings suggested that bilberry consumption demonstrated potential digestive health by attenuating of intestinal inflammation, improving microbial profiles, and exhibiting mucosal energy metabolism.
Taken altogether, bilberry processed a high amount bioactive compound may be considered a functional remedy for optimizing the bodily health by balancing the levels of gut microbiota.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X. (PubMed)
(2) Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice by Päivärinta E1, Niku M2, Maukonen J3, Storvik M4, Heiman-Lindh A5, Saarela M6, Pajari AM7, Mutanen M. (PubMed)
(3) Part 1: The Human Gut Microbiome in Health and Disease by Matthew J. Bull, BSc, Ph.D. and Nigel T. Plummer, Ph.D. (PMC)
(4) Gut Microbiota and Obesity by Kyle J. Wolfa and Robin G. Lorenz. (PMC)
Wednesday, March 27, 2019
Avocado-Soybean Unsaponifiables (ASUs), A Natural Treatment of Osteoarthritis, with No side Effects, Studies Showed
Avocado may be considered a functional food for the prevention and treatment of osteoarthritis, some scientists suggested.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
The fruit is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Osteoarthritis is a group of diseases involved progressive denegation of joints, including articular cartilage and subchondral bone.
According to the statistic, osteoarthritis (OA) is the most common joint disorder in the US, affecting over 10% men and 13% in women aged 60 years or older. The disease can also affect the younger population, after a traumatic injury.
.
Epidemiological studies suggested that symptoms progress slowly and contribute to workplace disability and reduced quality of life.
Dr. Hofmann S, the lead scientist in the team of arthritis in the examine the mechanical causes of osteoarthritis in young adults suggested that that certain conditions such as femoroacetabular impingement (a condition in which extra bone grows along one or both of the bones that form the hip joint) are a very common cause of secondary osteoarthritis (OA) in the young adults" and "
It is an important co-factor in the better recognized pre-arthritic deformities such as residual hip dysplasia (RHD), Perthes disease and slipped capital femoral epiphysis (SCFE)".
These results clearly indicated genetic mutation and mechanical deformity are major causes of osteoarthritis in the younger adult besides athletic injury.
Some scientists proposed that the development of femoroacetabular impingement may be a result of a repetitive injury to the proximal femoral physis occurs during a critical period of development.
With an aim to find a natural ingredient for the prevention and treatment of osteoarthritis, a disease associated with the progressive denegation of joints, researchers at the Universities of Exeter and Plymouth assessed the anti-OA of the compounds Avocado/soybean unsaponifiables (ASU) which have shown some promise for OA.
By searching the database of medical literature, researchers found 4 randomized, placebo-controlled, double-blind trials of ASU.satisified the guideline and criteria.
The doses per day in the 4 studies are in the range between 300 mg and with 600 mg.
3 out of 4 studies suggest that ASU is effective for the symptomatic treatment of OA.
Furthermore, the Hôpital Léopold Bellan launched a follow-up study to investigate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients in the hip, included 163 patients, 102 men and 61 women (mean age 63.2 +/- 8.7 years).
Participants in the study are patients with regular painful primary OA of the hip (European League Against Rheumatism 1980 criteria) and a joint space still > or = 1 mm were selected entered a prospective, multicenter, randomized, parallel group, double-blind, placebo-controlled trial of 2 years duration.
ASU treatment group showed a lesser joint space loss compared to the significantly greater loss in the placebo group.
The clinical parameters in the 2 groups did not differ significantly throughout the study.
These results indicated a significant effect of ASU against the progression of joint loss in OA patients.
Dr,. the lead scientists said, "SU significantly reduced the progression of joint space loss as compared with placebo in the subgroup of patients with advanced joint space narrowing".
Taken altogether, avocado-soybean unsaponifiables (ASUs) may have a profound effect in reducing the symptoms and progression of osteoarthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Avocado-soybean unsaponifiables (ASU) for osteoarthritis - a systematic review by Ernst E.(PubMed)
(2) Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(3) Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip by Lequesne M1, Maheu E, Cadet C, Dreiser RL. (PubMed)
(4) Mechanical causes of osteoarthritis in young adults by Hofmann S, Tschauner Ch, Graf R.(PubMed)
(5) The etiology of primary femoroacetabular impingement: genetics or acquired deformity? by Jonathan D. Packer and Marc R. Safran. (PMC)
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
The fruit is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Osteoarthritis is a group of diseases involved progressive denegation of joints, including articular cartilage and subchondral bone.
According to the statistic, osteoarthritis (OA) is the most common joint disorder in the US, affecting over 10% men and 13% in women aged 60 years or older. The disease can also affect the younger population, after a traumatic injury.
.
Epidemiological studies suggested that symptoms progress slowly and contribute to workplace disability and reduced quality of life.
Dr. Hofmann S, the lead scientist in the team of arthritis in the examine the mechanical causes of osteoarthritis in young adults suggested that that certain conditions such as femoroacetabular impingement (a condition in which extra bone grows along one or both of the bones that form the hip joint) are a very common cause of secondary osteoarthritis (OA) in the young adults" and "
It is an important co-factor in the better recognized pre-arthritic deformities such as residual hip dysplasia (RHD), Perthes disease and slipped capital femoral epiphysis (SCFE)".
These results clearly indicated genetic mutation and mechanical deformity are major causes of osteoarthritis in the younger adult besides athletic injury.
Some scientists proposed that the development of femoroacetabular impingement may be a result of a repetitive injury to the proximal femoral physis occurs during a critical period of development.
With an aim to find a natural ingredient for the prevention and treatment of osteoarthritis, a disease associated with the progressive denegation of joints, researchers at the Universities of Exeter and Plymouth assessed the anti-OA of the compounds Avocado/soybean unsaponifiables (ASU) which have shown some promise for OA.
By searching the database of medical literature, researchers found 4 randomized, placebo-controlled, double-blind trials of ASU.satisified the guideline and criteria.
The doses per day in the 4 studies are in the range between 300 mg and with 600 mg.
3 out of 4 studies suggest that ASU is effective for the symptomatic treatment of OA.
Furthermore, the Hôpital Léopold Bellan launched a follow-up study to investigate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients in the hip, included 163 patients, 102 men and 61 women (mean age 63.2 +/- 8.7 years).
Participants in the study are patients with regular painful primary OA of the hip (European League Against Rheumatism 1980 criteria) and a joint space still > or = 1 mm were selected entered a prospective, multicenter, randomized, parallel group, double-blind, placebo-controlled trial of 2 years duration.
ASU treatment group showed a lesser joint space loss compared to the significantly greater loss in the placebo group.
The clinical parameters in the 2 groups did not differ significantly throughout the study.
These results indicated a significant effect of ASU against the progression of joint loss in OA patients.
Dr,. the lead scientists said, "SU significantly reduced the progression of joint space loss as compared with placebo in the subgroup of patients with advanced joint space narrowing".
Taken altogether, avocado-soybean unsaponifiables (ASUs) may have a profound effect in reducing the symptoms and progression of osteoarthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Avocado-soybean unsaponifiables (ASU) for osteoarthritis - a systematic review by Ernst E.(PubMed)
(2) Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(3) Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip by Lequesne M1, Maheu E, Cadet C, Dreiser RL. (PubMed)
(4) Mechanical causes of osteoarthritis in young adults by Hofmann S, Tschauner Ch, Graf R.(PubMed)
(5) The etiology of primary femoroacetabular impingement: genetics or acquired deformity? by Jonathan D. Packer and Marc R. Safran. (PMC)
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