Bone healing is a natural process of broken bone healing. The bone healing process goes through three overlapping stages, including inflammation, soft and callus production, and bone remodeling.
Improper bone healing occurred when two ends of the broken bone are not lined up properly, leading to the bone healing with a deformity called a malunion.
Most cases of improper bone healing have been found to involve angulation (bend) and/or rotation flexibility or extension. In some cases, improper bone healing can also cause stiffness in the finger, hand, wrist or elbow.
If you experience some of the above symptoms after a broken bone, you may have an improper bone healing. Please check with your doctor to rule out the possibility.
Some researchers in the concern of the risk of improper bone healing in obese patients wrote, "Obesity is a risk factor for various orthopedic diseases, including fractures. Obesity's influence on circulating hormones and cytokines and bone mineralization ultimately influence the body's osteogenic response and bone mineralization, potentially increasing the risk of fracture and impacting fracture healing".
Luckily, the doctor continued, "Obese/overweight children did not have a delay in release to activities compared with children of normal weight".
The results strongly suggested the correlation between obese and the risk of bone fracture and fracture healing in children.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural remedy for speed-up bone healthy investigation honey activity on
alveolar osteitis (OA).
Alveolar osteitis (AO) is a complication of tooth extraction.
50 patients of AO were included in the study. After cleansing of the affected socket, honey dressings applied were changed daily for the first 2 days and then alternatively.
Honey application sped up the bone and granulation tissue healing and gingiva healing in about one week on most patients.
According to the reading of the CRP levels, treatment of AO with honey dressing showed a significant decrease from the pre-treatment values, an indication of fast recovery for inflammation.
The microbiological assay also showed the presence of normal commensal flora at AO sites including Streptococcus, Staphylococcus, and Enterococcus.
The results suggested that honey topical dressing speeds up bone healing and tissue recovery through inhibiting microbial overexpression and production of pro-inflammatory cytokines.
In order to reveal more information about bone healing of honey, researchers examined the honey on the healing of mandibular bone defects in a rat model.
24 wild-type Wistar rats included in the study were shaved, disinfected and extraoral incised with a 2 × 2 mm defect at mandibular angle. Only the experimental group defect was filled with sterile honey.
After 4 weeks, the defects were filled in four samples of the honey treatment group, compared to all samples of the control group which is still in the mineralization stage.
According to the histomorphometric assay, honey treatment showed a significant improvement in the mean new bone formation compared to those of the control group, both after 2 and 4 weeks.
Taken altogether, honey may speed up bone healing without inducing any side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of Topical Honey on Mandibular Bone Defect Healing in Rats by Hajizadeh F1, Derakhshan B2, Peimani A3, Abbasi Z. (PubMed)
(2) Effects of honey in the management of alveolar osteitis: A study by Soni N1, Singh V1, Mohammad S1, Singh RK1, Pal US1, Singh R2, Aggrwal J3, Pal M. (PubMed)
(3) Does obesity affect fracture healing in children? by Lee RJ1, Hsu NN, Lenz CM, Leet AI. (PubMed)
Friday, April 26, 2019
Thursday, April 25, 2019
Herbal Artichoke, the Best Hepatoprotecitve Functional Remedy, According to Studies
The hepatoprotective or liver protective effect is an action that maintains the liver healthy functioning against any harmful toxins.
The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood come from the digestive tract, before passing it to the rest of the body.
Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and tendency to bruise easily.
If you experience some of the above symptoms, please make sure that you check with your doctor to rule out the possibility of liver diseases.
Most cases of liver disease are associated with hepatitis viral infection and autoimmune diseases. However, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
Dr. Suthat Liangpunsakul, the lead scientist, in the comparison of alcoholic disease in different regions wrote, "Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis".
And, " Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include a pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe".
The results clearly and strongly suggested that reducing intake alcohol and following a healthy diet pattern is the best way to decrease the risk of liver diseases, including the ALD.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detox agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural ingredient which processes liver protective effect evaluated the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice.
Selected male mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily before administrated up to 40% alcohol (12 mL/kg body weight) orally 1 h after artichoke treatment for 10 consecutive days.
Injection of artichoke extract not only significantly prevented elevated levels of aspartate aminotransferase, alanine aminotransferase, the liver oxidative stress markers but also reduced the levels of triglyceride, total cholesterol.
Artichoke treatment mice also restored the levels of antioxidant enzymes which were reduced by the injection of alcohol.
According to the immunohistochemical analysis, artichoke also suppressed the levels of toll-like receptor (TLR) 4 which plays a critical role in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines and protein, nuclear factor-kappa B (NF-κB) associated with liver cells apoptosis in liver tissues.
The results indicated a liver protective activity in artichoke was attributed to the inhibition of the proinflammatory proteins in acute alcohol-induced liver injury mice.
In order to reveal more information about the liver protective effect of artichoke, researchers examined the herbal medicine against liver fibrosis, the main pathology of schistosomiasis and its complications are the major cause of death in infected cases.
Mice selected to the study infected with Schistosoma mansoni (S. mansoni) were divided into 5 groups. The first three groups were given artichoke leaf extract (ALE), ALE + praziquantel (PZQ) and PZQ respectively. The 4th was a positive control and the 5th was the negative control group.and were compared to PZQ.
Injection of ALE and ALE + praziquantel (PZQ) caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis.
Furthermore, ALE induced statistically significant changes in hepatic stellate cells (HSCs) distribution.
Moreover, ALE also reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.
Unfortunately, although, the herbal extract exerted a strong liver protective activity, it but failed to treat S. mansoni infection.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver disease, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Liver protective effects
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) [Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].[Article in Polish] by Horoszkiewicz M1, Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Wachowiak A, Florek E.(PubMed)
(4) Alcoholic Liver Disease in Asia, Europe, and North America by Suthat Liangpunsakul, Paul Haber, and Geoff McCaughan. (PMC)
The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood come from the digestive tract, before passing it to the rest of the body.
Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.
Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, and pale stool color, and tendency to bruise easily.
If you experience some of the above symptoms, please make sure that you check with your doctor to rule out the possibility of liver diseases.
Most cases of liver disease are associated with hepatitis viral infection and autoimmune diseases. However, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
Dr. Suthat Liangpunsakul, the lead scientist, in the comparison of alcoholic disease in different regions wrote, "Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis".
And, " Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include a pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe".
The results clearly and strongly suggested that reducing intake alcohol and following a healthy diet pattern is the best way to decrease the risk of liver diseases, including the ALD.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detox agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural ingredient which processes liver protective effect evaluated the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice.
Selected male mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily before administrated up to 40% alcohol (12 mL/kg body weight) orally 1 h after artichoke treatment for 10 consecutive days.
Injection of artichoke extract not only significantly prevented elevated levels of aspartate aminotransferase, alanine aminotransferase, the liver oxidative stress markers but also reduced the levels of triglyceride, total cholesterol.
Artichoke treatment mice also restored the levels of antioxidant enzymes which were reduced by the injection of alcohol.
According to the immunohistochemical analysis, artichoke also suppressed the levels of toll-like receptor (TLR) 4 which plays a critical role in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines and protein, nuclear factor-kappa B (NF-κB) associated with liver cells apoptosis in liver tissues.
The results indicated a liver protective activity in artichoke was attributed to the inhibition of the proinflammatory proteins in acute alcohol-induced liver injury mice.
In order to reveal more information about the liver protective effect of artichoke, researchers examined the herbal medicine against liver fibrosis, the main pathology of schistosomiasis and its complications are the major cause of death in infected cases.
Mice selected to the study infected with Schistosoma mansoni (S. mansoni) were divided into 5 groups. The first three groups were given artichoke leaf extract (ALE), ALE + praziquantel (PZQ) and PZQ respectively. The 4th was a positive control and the 5th was the negative control group.and were compared to PZQ.
Injection of ALE and ALE + praziquantel (PZQ) caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis.
Furthermore, ALE induced statistically significant changes in hepatic stellate cells (HSCs) distribution.
Moreover, ALE also reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.
Unfortunately, although, the herbal extract exerted a strong liver protective activity, it but failed to treat S. mansoni infection.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of liver disease, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Liver protective effects
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) [Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].[Article in Polish] by Horoszkiewicz M1, Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Wachowiak A, Florek E.(PubMed)
(4) Alcoholic Liver Disease in Asia, Europe, and North America by Suthat Liangpunsakul, Paul Haber, and Geoff McCaughan. (PMC)
Curcumin, the Bioactive Compound of Turmeric Protects the Blood Vessels Against Cardiovascular Disease
Cardiovascular disease (CVD) refers to any conditions caused by the underlying damage of blood vessels and the heart.
In other words, depending on the location of the blockage or disruption, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack) or stroke.
According to the statistics provided by the American Heart Association, approximately 84 million people in this US suffer from some form of cardiovascular disease, leading to the death of about 2,200 people a day.
The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight and smoking.
Epidemiological studies suggested that most people with CVD are also associated with atherosclerosis, a condition caused by long-term plaque buildup on artery walls, which can narrow the arteries and reduce blood flow through your arteries to the heart.
Some researchers suggested the promotion of the Western diet over the past few decades may have a strong implication on the rise of CVD.
Dr. Mirmiran P, the lead scientist, in the examination of the diet pattern and the risk of CVD in Iran, said, "During a mean 4.7 ± 1.4 years of follow-up, 57 participants experienced CVD-related events. In the fully adjusted model, we observed an increased risk of CVD-related events in the highest compared to the lowest tertile category of Western dietary pattern score (HR = 2.07, 95% CI = 1.03-4.18, P for trend = 0.01)".
And "the Western dietary pattern, characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks, is a dietary risk factor for CVD in the Iranian population".
The results strongly indicated the increased risk of CVD in people who follow the Western diet pattern.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a potential compound for the treatment of cardiovascular disease (CVD) associated with the largest mortality worldwide, scientists examined the cardiovascular protective properties of curcumin in CVDs.
According to the review, curcumin showed significant activity against the onset of CVDs, including cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke, and diabetic cardiovascular complications.
In dyslipidemia, an important and common cardiovascular risk factor in the general population, researchers assessed the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD), through searching the database of medical literature.
The comprehensive literature search conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases were to identify randomized controlled trials (published as of November 2016).
Based on the results of 7 eligible studies (649 patients) satisfied the guideline and criteria, researchers found that
* Turmeric and curcumin significantly reduced serum low-density lipoprotein cholesterol (LDL-C) levels as compared to those in the control group.
* Turmeric and curcumin also were effective in lowering serum total cholesterol (TC), levels in patients with metabolic syndrome.
* Turmeric extract have a greater effect on reducing serum TC levels compared to curcumin.
* Both turmeric and curcumin did not improve the serum high-density lipoprotein cholesterol (HDL-C).
* More importantly, turmeric and curcumin are safe, and no serious adverse events were reported in any of the included studies.
Dr. Qin S, the lead researcher wrote, "Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".
Taken altogether, turmeric and its bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, the golden spice in treating cardiovascular diseases by Li H1, Sureda A2, Devkota HP3, Pittalà V4, Barreca D5, Silva AS6, Tewari D7, Xu S8, Nabavi SM. (PubMed)
(2) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(3) Western dietary pattern increases risk of cardiovascular disease in Iranian adults: a prospective population-based study by Mirmiran P1, Bahadoran Z2, Vakili AZ3, Azizi F. (PubMed)
In other words, depending on the location of the blockage or disruption, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack) or stroke.
According to the statistics provided by the American Heart Association, approximately 84 million people in this US suffer from some form of cardiovascular disease, leading to the death of about 2,200 people a day.
The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight and smoking.
Epidemiological studies suggested that most people with CVD are also associated with atherosclerosis, a condition caused by long-term plaque buildup on artery walls, which can narrow the arteries and reduce blood flow through your arteries to the heart.
Some researchers suggested the promotion of the Western diet over the past few decades may have a strong implication on the rise of CVD.
Dr. Mirmiran P, the lead scientist, in the examination of the diet pattern and the risk of CVD in Iran, said, "During a mean 4.7 ± 1.4 years of follow-up, 57 participants experienced CVD-related events. In the fully adjusted model, we observed an increased risk of CVD-related events in the highest compared to the lowest tertile category of Western dietary pattern score (HR = 2.07, 95% CI = 1.03-4.18, P for trend = 0.01)".
And "the Western dietary pattern, characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks, is a dietary risk factor for CVD in the Iranian population".
The results strongly indicated the increased risk of CVD in people who follow the Western diet pattern.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a potential compound for the treatment of cardiovascular disease (CVD) associated with the largest mortality worldwide, scientists examined the cardiovascular protective properties of curcumin in CVDs.
According to the review, curcumin showed significant activity against the onset of CVDs, including cardiac hypertrophy, heart failure, drug-induced cardiotoxicity, myocardial infarction, atherosclerosis, abdominal aortic aneurysm, stroke, and diabetic cardiovascular complications.
In dyslipidemia, an important and common cardiovascular risk factor in the general population, researchers assessed the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD), through searching the database of medical literature.
The comprehensive literature search conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases were to identify randomized controlled trials (published as of November 2016).
Based on the results of 7 eligible studies (649 patients) satisfied the guideline and criteria, researchers found that
* Turmeric and curcumin significantly reduced serum low-density lipoprotein cholesterol (LDL-C) levels as compared to those in the control group.
* Turmeric and curcumin also were effective in lowering serum total cholesterol (TC), levels in patients with metabolic syndrome.
* Turmeric extract have a greater effect on reducing serum TC levels compared to curcumin.
* Both turmeric and curcumin did not improve the serum high-density lipoprotein cholesterol (HDL-C).
* More importantly, turmeric and curcumin are safe, and no serious adverse events were reported in any of the included studies.
Dr. Qin S, the lead researcher wrote, "Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".
Taken altogether, turmeric and its bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiovascular disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, the golden spice in treating cardiovascular diseases by Li H1, Sureda A2, Devkota HP3, Pittalà V4, Barreca D5, Silva AS6, Tewari D7, Xu S8, Nabavi SM. (PubMed)
(2) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(3) Western dietary pattern increases risk of cardiovascular disease in Iranian adults: a prospective population-based study by Mirmiran P1, Bahadoran Z2, Vakili AZ3, Azizi F. (PubMed)
Wednesday, April 24, 2019
Herbal Calendula, Protects Lipid, Protein and Cells DNA Against Damage Caused by Oxidative Stress
Scientists may have found a natural remedy for the prevention and treatment of the diseases associated with the expression of oxidative stress, according to studies.
Antioxidants are stable molecules that inhibit the oxidation induced by free radical.
Free radicals are unstable and high reactive molecules with a single electron in the outer ring.
In order for them to become stable, free radicals are ready to donate or intercept an electron from other molecules, leading to a chain reaction that cannot be stopped until the electrons on the outer ring are paired or inhibited by antioxidants.
Oxidative stress is a condition caused by either overexpression of free radical or low levels of antioxidant enzymes produced by the host body.
In other words, the unbalanced ratio of the levels of free radicals and antioxidants enzymes is the major cause of the onset of oxidative stress, leading to the damage of lipid, DNA, and protein in the cells of the host.
Although there are many risk factors associated with the development of the condition, some researchers suggested that smoking is one of the preventable and major risks in the induction of the onset of oxidative stress.
Dr. Isik B in the comparison of the risk of oxidative stress in smokers and nonsmokers wrote, "Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through the weakening of the antioxidant defense systems".
And, ": The serum MDA levels were significantly higher (p < .05) and serum PON1 activities were significantly lower (p < .001) in smokers than in nonsmokers".
Where serum malondialdehyde (MDA) is an oxidative stress marker and paraoxonase (PON1) is an HDL-associated enzyme which protects the HDL against oxidation.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herbal medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Researchers on finding herbal medicine which process a high amount of antioxidants examined the
Calendula officinalis flower extract effects against experimentally induced thermal burns made on the shaven back of the rats under anesthesia in rats.
The animals then are treated orally with different doses of the flower extracts (20 mg, 100 mg, and 200 mg/kg body weight).
Injection of the extracts showed significant improvement in healing when compared with the control untreated animals.
The wound healing is observed by the speeding up through the increase of the concentration of collagen contents in the treated group.
The acute phase proteins associated with the oxidative activity was increased due to burning were found to be decreased significantly in 200 mg/kg body weight extract treated animals.
The antioxidant defense mechanism decreased in the liver during burn injury, was found to be enhanced in treated animals.
The lipid peroxidation was significantly lowered in the treated group, accompanied by a decrease of the tissue damage marker compared to control animals.
Furthermore, in the investigation of the Flower extract of C. officinalis L. protective effect against CCl4 induced acute hepatotoxicity and cisplatin-induced nephrotoxicity, pretreatment of the flower extract at 100 and 250 mg/kg body weight exerted a significant reduction of the tissue and oxidative stress makers compared to untreated group.
The extract displayed a liver protective effect observed by the decreased levels of lipid peroxidation the marker of membrane damage and the total bilirubin content in the liver.
Moreover, the herbal extract also demonstrated kidney protective effects observed by the reduced levels of the kidney function markers, urea, and creatinine which were significantly increased in cisplatin-treated animals.
Additionally, the cisplatin-induced myelosuppression was ameliorated by the extract pretreatment, through enhancing the levels of antioxidant enzymes, such as superoxide dismutase and catalase and glutathione.
Dr. Preethi KC, the lead scientist wrote in the final report, "Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals".
Taken altogether, herbal Calendula may be considered a functional remedy for the protection of our body against disease associated with oxidative stress, through its antioxidant activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. by Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, Baradaran M, Kazemi MT, Khalilpour A, Pouramir M, Moghadamnia AA. (PubMed)
(2) Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns by Chandran PK, Kuttan R.(PubMed)
(3) Hepato and reno protective action of Calendula officinalis L. flower extract by Preethi KC, Kuttan R.(PubMed)
Antioxidants are stable molecules that inhibit the oxidation induced by free radical.
Free radicals are unstable and high reactive molecules with a single electron in the outer ring.
In order for them to become stable, free radicals are ready to donate or intercept an electron from other molecules, leading to a chain reaction that cannot be stopped until the electrons on the outer ring are paired or inhibited by antioxidants.
Oxidative stress is a condition caused by either overexpression of free radical or low levels of antioxidant enzymes produced by the host body.
In other words, the unbalanced ratio of the levels of free radicals and antioxidants enzymes is the major cause of the onset of oxidative stress, leading to the damage of lipid, DNA, and protein in the cells of the host.
Although there are many risk factors associated with the development of the condition, some researchers suggested that smoking is one of the preventable and major risks in the induction of the onset of oxidative stress.
Dr. Isik B in the comparison of the risk of oxidative stress in smokers and nonsmokers wrote, "Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through the weakening of the antioxidant defense systems".
And, ": The serum MDA levels were significantly higher (p < .05) and serum PON1 activities were significantly lower (p < .001) in smokers than in nonsmokers".
Where serum malondialdehyde (MDA) is an oxidative stress marker and paraoxonase (PON1) is an HDL-associated enzyme which protects the HDL against oxidation.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herbal medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Researchers on finding herbal medicine which process a high amount of antioxidants examined the
Calendula officinalis flower extract effects against experimentally induced thermal burns made on the shaven back of the rats under anesthesia in rats.
The animals then are treated orally with different doses of the flower extracts (20 mg, 100 mg, and 200 mg/kg body weight).
Injection of the extracts showed significant improvement in healing when compared with the control untreated animals.
The wound healing is observed by the speeding up through the increase of the concentration of collagen contents in the treated group.
The acute phase proteins associated with the oxidative activity was increased due to burning were found to be decreased significantly in 200 mg/kg body weight extract treated animals.
The antioxidant defense mechanism decreased in the liver during burn injury, was found to be enhanced in treated animals.
The lipid peroxidation was significantly lowered in the treated group, accompanied by a decrease of the tissue damage marker compared to control animals.
Furthermore, in the investigation of the Flower extract of C. officinalis L. protective effect against CCl4 induced acute hepatotoxicity and cisplatin-induced nephrotoxicity, pretreatment of the flower extract at 100 and 250 mg/kg body weight exerted a significant reduction of the tissue and oxidative stress makers compared to untreated group.
The extract displayed a liver protective effect observed by the decreased levels of lipid peroxidation the marker of membrane damage and the total bilirubin content in the liver.
Moreover, the herbal extract also demonstrated kidney protective effects observed by the reduced levels of the kidney function markers, urea, and creatinine which were significantly increased in cisplatin-treated animals.
Additionally, the cisplatin-induced myelosuppression was ameliorated by the extract pretreatment, through enhancing the levels of antioxidant enzymes, such as superoxide dismutase and catalase and glutathione.
Dr. Preethi KC, the lead scientist wrote in the final report, "Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals".
Taken altogether, herbal Calendula may be considered a functional remedy for the protection of our body against disease associated with oxidative stress, through its antioxidant activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. by Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, Baradaran M, Kazemi MT, Khalilpour A, Pouramir M, Moghadamnia AA. (PubMed)
(2) Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns by Chandran PK, Kuttan R.(PubMed)
(3) Hepato and reno protective action of Calendula officinalis L. flower extract by Preethi KC, Kuttan R.(PubMed)
Honey, the Best Remedy for the Prevention and Treatment of Diarrhea
Scientists may have found a natural alternative for the treatment of diarrhea, according to studies.
Diarrhea is a condition of loose, watery stools. Acute diarrhea is a common problem in North American that lasts in a very short time.
However, chronic diarrhea can be worrisome. Most common causes of chronic diarrhea are diseases associated with the gastrointestinal tract, including irritable bowel syndrome (IBS), inflammatory bowel disease (Crohn disease and ulcerative colitis), malabsorption syndromes.
According to the statistics, acute diarrhea is one of the common cause of death among children younger than 5 years old worldwide.
The disease is associated mostly in the countries which poor environmental sanitation, inadequate water supplies, and poverty.
There are many risk factors involved the onset of the syndrome, including demography, socio-economy, poor water supply, poor sanitation, poor hygiene practices, breastfeeding, and malnutrition.
Some researchers suggested that a severely weakened immune system such as the use of immune suppressive medicine and the elderly may also at a higher risk of diarrhea.
Dr. Bouchaud O in examing the risk immune deficiency and diarrhea wrote, "With a prevalence of approximatively 50%, diarrhea is a frequent event in an immune deficiency of any cause".
And "Gram-negative infections and Clostridium difficile colitis have to be diagnosed because effective treatment is available. In these patients usually in bad general condition, because diarrhea is often of unknown etiology or noncurable, the diagnostic and therapeutic strategy has to be pragmatic in order to control the symptoms without an excess of invasive procedures".
These results clearly suggested that if you have a severely weakened immune system, you are at higher risk of bacterial infected diarrhea.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on searching a natural compound for the treatment of diarrhea evaluated the honey gastroprotective effect against diarrhea.
Injection of honey induced a significant reduction in the duration of bacterial diarrhea, and it had worked well as a substitute for glucose in an oral rehydration solution containing electrolytes.
In nonbacterial gastroenteritis, honey exerted a similar effect as glucose on the duration of diarrhea.
In an array of gram-positive and gram-negative bacteria, most pathogenic bacteria failed to grow in honey at a concentration of 40% and above, similar to those studies of honey on Staphylococcus aureus, Proteus mirabilis, and Candida albicans failed to grow in the presence of undiluted honey in vitro experiments.
Honey-agar all intestinal bacterial pathogens failed to grow at a concentration of 40% and above of pure honey, compared to those of bacterias in control plates and different growth media.
Scientists wrote in the final report, "Findings from studies on honey have thus shown that when given with an ORS it shortens the duration of bacterial diarrhea and may safely be used as a substitute for glucose, provided that the solution contains electrolytes".
In order to reveal more information about honey anti-diarrhea activity, researchers examined the honey on diarrhea and fecal microbiota in critically ill patients.
The double-blind, randomized controlled single-center study, included 32 patients randomly selected to receive a high protein kitchen enteral diet or honey as 10% of its carbohydrate intake.
The treatment group showed an insignificant increase in the frequency of bifidobacterium DNA by study day 7 in comparison with the control group and a considerable reduction in diarrhea.
Honey group also reduced the length of the Intensive Care Unit and the development of organ failure in critically ill patients.
Taken altogether, honey may be considered a functional remedy for the prevention and treatment of diarrhea, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Honey: its antibacterial action in the treatment of gastroenteritis.[No authors listed]. (PubMed)
(2) Effect of Honey on Diarrhea and Fecal Microbiotain in Critically Ill Tube-Fed Patients: A Single Center Randomized Controlled Study by Zahra Vahdat Shariatpanahi,1 Fatemeh Jamshidi,1 Javad Nasrollahzadeh,1 Zohreh Amiri,1 andHouman Teymourian. (PubMed)
(3) [Diarrhea in immune deficiency status].[Article in French] by Bouchaud O. (PubMed)
Diarrhea is a condition of loose, watery stools. Acute diarrhea is a common problem in North American that lasts in a very short time.
However, chronic diarrhea can be worrisome. Most common causes of chronic diarrhea are diseases associated with the gastrointestinal tract, including irritable bowel syndrome (IBS), inflammatory bowel disease (Crohn disease and ulcerative colitis), malabsorption syndromes.
According to the statistics, acute diarrhea is one of the common cause of death among children younger than 5 years old worldwide.
The disease is associated mostly in the countries which poor environmental sanitation, inadequate water supplies, and poverty.
There are many risk factors involved the onset of the syndrome, including demography, socio-economy, poor water supply, poor sanitation, poor hygiene practices, breastfeeding, and malnutrition.
Some researchers suggested that a severely weakened immune system such as the use of immune suppressive medicine and the elderly may also at a higher risk of diarrhea.
Dr. Bouchaud O in examing the risk immune deficiency and diarrhea wrote, "With a prevalence of approximatively 50%, diarrhea is a frequent event in an immune deficiency of any cause".
And "Gram-negative infections and Clostridium difficile colitis have to be diagnosed because effective treatment is available. In these patients usually in bad general condition, because diarrhea is often of unknown etiology or noncurable, the diagnostic and therapeutic strategy has to be pragmatic in order to control the symptoms without an excess of invasive procedures".
These results clearly suggested that if you have a severely weakened immune system, you are at higher risk of bacterial infected diarrhea.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on searching a natural compound for the treatment of diarrhea evaluated the honey gastroprotective effect against diarrhea.
Injection of honey induced a significant reduction in the duration of bacterial diarrhea, and it had worked well as a substitute for glucose in an oral rehydration solution containing electrolytes.
In nonbacterial gastroenteritis, honey exerted a similar effect as glucose on the duration of diarrhea.
In an array of gram-positive and gram-negative bacteria, most pathogenic bacteria failed to grow in honey at a concentration of 40% and above, similar to those studies of honey on Staphylococcus aureus, Proteus mirabilis, and Candida albicans failed to grow in the presence of undiluted honey in vitro experiments.
Honey-agar all intestinal bacterial pathogens failed to grow at a concentration of 40% and above of pure honey, compared to those of bacterias in control plates and different growth media.
Scientists wrote in the final report, "Findings from studies on honey have thus shown that when given with an ORS it shortens the duration of bacterial diarrhea and may safely be used as a substitute for glucose, provided that the solution contains electrolytes".
In order to reveal more information about honey anti-diarrhea activity, researchers examined the honey on diarrhea and fecal microbiota in critically ill patients.
The double-blind, randomized controlled single-center study, included 32 patients randomly selected to receive a high protein kitchen enteral diet or honey as 10% of its carbohydrate intake.
The treatment group showed an insignificant increase in the frequency of bifidobacterium DNA by study day 7 in comparison with the control group and a considerable reduction in diarrhea.
Honey group also reduced the length of the Intensive Care Unit and the development of organ failure in critically ill patients.
Taken altogether, honey may be considered a functional remedy for the prevention and treatment of diarrhea, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Honey: its antibacterial action in the treatment of gastroenteritis.[No authors listed]. (PubMed)
(2) Effect of Honey on Diarrhea and Fecal Microbiotain in Critically Ill Tube-Fed Patients: A Single Center Randomized Controlled Study by Zahra Vahdat Shariatpanahi,1 Fatemeh Jamshidi,1 Javad Nasrollahzadeh,1 Zohreh Amiri,1 andHouman Teymourian. (PubMed)
(3) [Diarrhea in immune deficiency status].[Article in French] by Bouchaud O. (PubMed)
Monday, April 22, 2019
Herbal Artichoke, The Best For the Treatment of Insulin Resistance (IR) in Patients with TCF7L2-rs7903146 Polymorphism
Scientists may have found a natural whole food for the treatment of insulin resistance with no side effects, according to studies.
Insulin resistance is a syndrome in which the cells in your muscles, fat, and liver do not respond well to insulin produced by the pancreas in converting glucose to energy, leading to high levels of sugar in the blood.
The causes of insulin resistance may be associated with the clogged up of the insulin receptor site that binds to insulin and passes its message to the cell.
Insulin resistance is a hallmark of diabetes.
Prediabetes is a term used to indicate a high level of blood glucose levels is higher compared to the normal range but not high enough to be diagnosed as diabetes.
The increase in age, family history, high blood pressure, high blood cholesterol, and abnormal waist-hip ratio are some prevalent risk factor of insulin resistance.
Interestingly, in the concern of long-term use of certain medication in the risk of insulin resistance such as glucocorticoids, antipsychotic, researchers at the Monell Chemical Senses Center,wrote, "Atypical antipsychotic (AAP) medications that have revolutionized the treatment of mental illness have become stigmatized by metabolic side effects, including obesity and diabetes"
And, "olanzapine, an AAP highly associated with weight gain, causes significant elevations in postprandial insulin, glucagon-like peptide 1 (GLP-1), and glucagon coincident with insulin resistance compared with placebo. Aripiprazole, an AAP considered metabolically sparing, induces insulin resistance but has no effect on postprandial hormones".
The doctor team continued, "Importantly, the metabolic changes occur in the absence of weight gain, increases in food intake and hunger, or psychiatric disease".
The findings suggested that if you are taking a certain medication for the treatment of anxiety, please make sure you discuss the side effects with your doctor for preventive measure.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of insulin resistance examined the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome (MetS).
The double-blind clinical trial included 80 patients with MetS in Sina Clinic, Khoy, Iran. randomly assigned to ALE or placebo groups to receive either ALE (1800 mg/d as four tablets) or matching placebo for 12 weeks.
According to the anthropometric indices, blood pressure, glucose and lipid profile levels measured before and after the study, injection of ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P < 0.05).
The finding strongly suggested that artichoke extract inhibited the expression of insulin resistance in a 12 weeks study in patients with the TCF7L2-rs7903146 polymorphism.
In order to reveal more information about artichoke extract anti-insulin resistance, researchers once again investigated the effects of ALE supplementation on metabolic parameters in women with MetS.
This study included a total of 50 women (aged 20-50 years) with MetS were randomly allocated into the two groups. with the "ALE group" (received 1,800 mg hydroalcoholic extract of artichoke as four tablets per day) and the "placebo group" (received placebo consisted of cornstarch, lactose, and avicel as four tablets per day) for 12 weeks.
Surprisingly, in the carriers of A allele of the FTO-rs9939609, ALE supplementation showed a statistically significant decrease in serum triglyceride level compared with placebo without affecting the insulin parameter.
The results strongly suggested that ALE inhibited the insulin resistance selectively only on patients with the TCF7L2-rs7903146 polymorphism.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of insulin resistance in carriers of the TCF7L2-rs7903146 polymorphism, pending to the results of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial by Ebrahimi-Mameghani M1, Asghari-Jafarabadi M2, Rezazadeh K. (PubMed)
(2) Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms by Rezazadeh K1, Rahmati-Yamchi M2, Mohammadnejad L3, Ebrahimi-Mameghani M4, Delazar A. (PubMed)
(3) Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease by Teff KL1, Rickels MR, Grudziak J, Fuller C, Nguyen HL, Rickels K. (PubMed)
Insulin resistance is a syndrome in which the cells in your muscles, fat, and liver do not respond well to insulin produced by the pancreas in converting glucose to energy, leading to high levels of sugar in the blood.
The causes of insulin resistance may be associated with the clogged up of the insulin receptor site that binds to insulin and passes its message to the cell.
Insulin resistance is a hallmark of diabetes.
Prediabetes is a term used to indicate a high level of blood glucose levels is higher compared to the normal range but not high enough to be diagnosed as diabetes.
The increase in age, family history, high blood pressure, high blood cholesterol, and abnormal waist-hip ratio are some prevalent risk factor of insulin resistance.
Interestingly, in the concern of long-term use of certain medication in the risk of insulin resistance such as glucocorticoids, antipsychotic, researchers at the Monell Chemical Senses Center,wrote, "Atypical antipsychotic (AAP) medications that have revolutionized the treatment of mental illness have become stigmatized by metabolic side effects, including obesity and diabetes"
And, "olanzapine, an AAP highly associated with weight gain, causes significant elevations in postprandial insulin, glucagon-like peptide 1 (GLP-1), and glucagon coincident with insulin resistance compared with placebo. Aripiprazole, an AAP considered metabolically sparing, induces insulin resistance but has no effect on postprandial hormones".
The doctor team continued, "Importantly, the metabolic changes occur in the absence of weight gain, increases in food intake and hunger, or psychiatric disease".
The findings suggested that if you are taking a certain medication for the treatment of anxiety, please make sure you discuss the side effects with your doctor for preventive measure.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a natural compound for the treatment of insulin resistance examined the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome (MetS).
The double-blind clinical trial included 80 patients with MetS in Sina Clinic, Khoy, Iran. randomly assigned to ALE or placebo groups to receive either ALE (1800 mg/d as four tablets) or matching placebo for 12 weeks.
According to the anthropometric indices, blood pressure, glucose and lipid profile levels measured before and after the study, injection of ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P < 0.05).
The finding strongly suggested that artichoke extract inhibited the expression of insulin resistance in a 12 weeks study in patients with the TCF7L2-rs7903146 polymorphism.
In order to reveal more information about artichoke extract anti-insulin resistance, researchers once again investigated the effects of ALE supplementation on metabolic parameters in women with MetS.
This study included a total of 50 women (aged 20-50 years) with MetS were randomly allocated into the two groups. with the "ALE group" (received 1,800 mg hydroalcoholic extract of artichoke as four tablets per day) and the "placebo group" (received placebo consisted of cornstarch, lactose, and avicel as four tablets per day) for 12 weeks.
Surprisingly, in the carriers of A allele of the FTO-rs9939609, ALE supplementation showed a statistically significant decrease in serum triglyceride level compared with placebo without affecting the insulin parameter.
The results strongly suggested that ALE inhibited the insulin resistance selectively only on patients with the TCF7L2-rs7903146 polymorphism.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of insulin resistance in carriers of the TCF7L2-rs7903146 polymorphism, pending to the results of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial by Ebrahimi-Mameghani M1, Asghari-Jafarabadi M2, Rezazadeh K. (PubMed)
(2) Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms by Rezazadeh K1, Rahmati-Yamchi M2, Mohammadnejad L3, Ebrahimi-Mameghani M4, Delazar A. (PubMed)
(3) Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease by Teff KL1, Rickels MR, Grudziak J, Fuller C, Nguyen HL, Rickels K. (PubMed)
Phytochemical Sinigrin Protects Our Body Against Chronic Inflammatory Diseases, According to PubMed
Scientists may have found a bioactive ingredient for the treatment of diseases associated with chronic inflammation, according to studies.
Inflammation is a natural process of the immune system which tries to protect our body against the invasion of stimuli and pathogens.
This process has been found to involve several stages after the bodily injury caused by physical impact or internal damage.
In the acute phase of infection, the white blood cells of the first line of immune defense stimulate to the production of blood coagulation to cover the wound and activate the protein associated with the production of inflammatory cytokines to kill off the invaders before they can enter the body.
However, overproduction of proinflammatory cytokines can lead to damage and death of the healthy cells, causing the irreversible scars as in liver hepatitis infection.
Chronic inflammation (CI) is a result in which the immune system can not destroy the invasive pathogens in the acute phase of infection within 3- 8 weeks, leading to the immune adaptation of the new change in facilitating low-grade inflammatory diseases, including arthritis and diabetes.
Out of a number of factors involved the onset of chronic inflammatory, some researchers suggested that the immune system dysfunction is one of the most prevalent risk factors in CI.
Dr. MARK HYMAN, MD in the article of inflammation & immune balance wrote, "If your immune system and your ability to balance the inflammatory forces in your body are impaired, watch out. You are headed toward illness and premature aging".
Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on searching the natural alternative compound with anti-inflammatory activity examined the sinigrin effects on adipogenesis in 3T3-L1 preadipocytes.
Injection of sinigrin remarkably inhibited the accumulation of lipid droplets and the process of cell differentiation associated with inflammation by inhibiting the expression of a protein involved key activators of adipogenesis, the CCAAT-enhancer-binding protein α (C/EBPα).
Furthermore, sinigrin also decreased the expression of peroxisome proliferator-activated receptor gamma (PPARγ), which plays in regulating adipogenesis, lipid metabolism, cell proliferation, inflammation, hormone leptin in the promotion of inflammation and the expansion of effector T cells (Teff) and the fatty acid-binding protein, aP2 coordinated with inflammatory activity.
Moreover, sinigrin arrested cells in the G0/G1 phase of the cell cycle against inflammation in the induction of cellular damage.
Additionally, sinigrin also increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), in reducing the immune inflammatory responses. mitogen-activated protein kinase (MAPK) and acetyl-CoA carboxylase (ACC) in regulating the fatty acid synthesis and degradation, in the early stage of adipocyte differentiation in adipocytes inflammation.
The anti proinflammation of sinigrin inhibition also are observed by limiting the production of pro-inflammatory cytokines including tumor necrosis factor -alpha (TNF-α) and interleukin (IL)-6, IL-1β and IL-18.
Dr. Lee HW and colleagues wrote in the final report, "sinigrin inhibits early-stage adipogenesis of 3T3-L1 adipocytes through the AMPK and MAPK signaling pathways".
The findings strongly suggested that sinigrin exerted a significant anti-inflammatory activity via several proteins and pathways.
Taken altogether, sinigrin may be considered a supplement for the prevention and combined with primary medicine for the treatment of diseases associated with chronic inflammation.
However, intake of supplement should be taken with exceptional care to prevent liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways by Lee HW1, Rhee DK1, Kim BO2, Pyo S. (PubMed)
(2) UltraWellness Lesson 2: Inflammation & Immune Balance by Dr. MARK HYMAN, MD
Inflammation is a natural process of the immune system which tries to protect our body against the invasion of stimuli and pathogens.
This process has been found to involve several stages after the bodily injury caused by physical impact or internal damage.
In the acute phase of infection, the white blood cells of the first line of immune defense stimulate to the production of blood coagulation to cover the wound and activate the protein associated with the production of inflammatory cytokines to kill off the invaders before they can enter the body.
However, overproduction of proinflammatory cytokines can lead to damage and death of the healthy cells, causing the irreversible scars as in liver hepatitis infection.
Chronic inflammation (CI) is a result in which the immune system can not destroy the invasive pathogens in the acute phase of infection within 3- 8 weeks, leading to the immune adaptation of the new change in facilitating low-grade inflammatory diseases, including arthritis and diabetes.
Out of a number of factors involved the onset of chronic inflammatory, some researchers suggested that the immune system dysfunction is one of the most prevalent risk factors in CI.
Dr. MARK HYMAN, MD in the article of inflammation & immune balance wrote, "If your immune system and your ability to balance the inflammatory forces in your body are impaired, watch out. You are headed toward illness and premature aging".
Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on searching the natural alternative compound with anti-inflammatory activity examined the sinigrin effects on adipogenesis in 3T3-L1 preadipocytes.
Injection of sinigrin remarkably inhibited the accumulation of lipid droplets and the process of cell differentiation associated with inflammation by inhibiting the expression of a protein involved key activators of adipogenesis, the CCAAT-enhancer-binding protein α (C/EBPα).
Furthermore, sinigrin also decreased the expression of peroxisome proliferator-activated receptor gamma (PPARγ), which plays in regulating adipogenesis, lipid metabolism, cell proliferation, inflammation, hormone leptin in the promotion of inflammation and the expansion of effector T cells (Teff) and the fatty acid-binding protein, aP2 coordinated with inflammatory activity.
Moreover, sinigrin arrested cells in the G0/G1 phase of the cell cycle against inflammation in the induction of cellular damage.
Additionally, sinigrin also increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), in reducing the immune inflammatory responses. mitogen-activated protein kinase (MAPK) and acetyl-CoA carboxylase (ACC) in regulating the fatty acid synthesis and degradation, in the early stage of adipocyte differentiation in adipocytes inflammation.
The anti proinflammation of sinigrin inhibition also are observed by limiting the production of pro-inflammatory cytokines including tumor necrosis factor -alpha (TNF-α) and interleukin (IL)-6, IL-1β and IL-18.
Dr. Lee HW and colleagues wrote in the final report, "sinigrin inhibits early-stage adipogenesis of 3T3-L1 adipocytes through the AMPK and MAPK signaling pathways".
The findings strongly suggested that sinigrin exerted a significant anti-inflammatory activity via several proteins and pathways.
Taken altogether, sinigrin may be considered a supplement for the prevention and combined with primary medicine for the treatment of diseases associated with chronic inflammation.
However, intake of supplement should be taken with exceptional care to prevent liver toxicity.
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways by Lee HW1, Rhee DK1, Kim BO2, Pyo S. (PubMed)
(2) UltraWellness Lesson 2: Inflammation & Immune Balance by Dr. MARK HYMAN, MD
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