Cancer is a class of disease caused by irregular cell growth in the tissue or organ associated with the alternation of cell DNA.
Most cancers at the early stage, due to the small size of the tumor are asymptomatic, However, as the cells continue to proliferation, at some points, the tumor may affect the nearby blood vessels and nerve cell leading to symptoms of severe pain and bleeding accompanied by the general symptoms shared by all cancers.
Most primary cancers at the advanced stage can also travel a distance away from the original site to infect other healthy tissues, leading to a secondary metastasis.
According to the statistics provided by the National Cancer Institute, based on 2011–2015 statistics. approximately, 439.2 per 100,000 men and women per year are diagnosed with cancer. The number of cancer deaths is 163.5 per 100,000 men and women per year, also based on 2011–2015 statistics.
Cancers are classified depending on the types of cells alternation
* Carcinoma
Carcinoma is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands.
* Sarcoma
Sarcoma is a type of cancer that arises from malignantly connective tissue cells originated from embryonic germ cells or bone, cartilage, and fat tissues and cells.
* Lymphoma and leukemia
Hematopoietic cells are multipotent stem cells that give rise to all types of the blood cell, including red blood cells, white blood cells, and platelets become cancerous.
* Germ cell tumor
The cancer is derived from pluripotent cells. In adults, these are most often found in the testicle and ovary, However, the cancer is more common in babies and young children.
* Blastoma
The cancer is derived from immature "precursor" or embryonic tissue. These are also most common in children.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential treatment of cancer with no side effect, researchers examined the protective effect of three garlic powder compared to that alliin.
Rat selected to the study were administered for 2 weeks with 5% garlic powder diet.
According to the comet assay, consumption of the different garlic powders induced a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.
Compared to the other garlic powders increased alliin content of the garlic powder was associated strongly with a proportional decrease in NDMA induced DNA alteration.
In other words, alliin increased anti-liver cancer activity of garlic powder proportionally compared to normal garlic powders.
Interestingly, DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon were also decreased strongly by the three garlic powders but these decreases were not correlated to the alliin content of the garlic powder.
In other words, all phytochemical compounds found in the garlic powder must work together to augment the anti-cancer effect regardless of the content of the individual compound.
In the study of liver cancer induced by injections of 0.025 mg/kg body weight aflatoxin B1 (AFB1) in rats, researchers garlic powder decreased the appearance and size of hepatic GST-P foci associated with early markers of the liver cancer.
However, garlic containing the highest level of alliin showed a stronger effect in the protection of liver against the forming hepatic GST-P foci compared to the normal garlic powders.
Levels of alliin showed an inverse associated with the number and area of preneoplastic foci.
Garlic powder ingestion increased the activity of hepatic detoxified enzymes such as glutathione S-transferase and UDP glucuronosyltransferase with no modification of nifedipine oxidase activity.
Dr. Bergès R, the lead researchers said, "It is suggested that garlic partly exerts its anticarcinogenic effects through increasing enzymes involved in AFB1 detoxification. This study highlights the possibility of controlling the cultivation conditions to improve the chemopreventive efficacy of garlic".
Taken altogether, alliin may be considered supplements for the prevention and treatment of cancer with no side effect, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats by Bergès R1, Siess MH, Arnault I, Auger J, Kahane R, Pinnert MF, Vernevaut MF, le Bon AM. (PubMed)
Saturday, May 11, 2019
Friday, May 10, 2019
Ginger, the Potential Remedy for the Prevention and Treatment of Head and Neck Cancer, According to Studies
Head and neck cancer is a class of cancer including the mouth, nose, throat, larynx, sinuses, or salivary glands.
Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organ, leading to secondary metastasis.
The exact causes of head and neck cancer are unknown. However, certain risk factors have been found to associate with the onset of the disease, including, excessive alcohol intake, smoking, infected by the HPV virus, poor oral health, race, long-term exposure to wood dust.
Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.
According to the statistics, in the US, HPV is the most common sexually transmitted virus.
Dr. Ankit Shah, the lead scientist in the examination of oral sex and human papillomavirus-related head and neck squamous cell cancer, wrote, "Unprotected sexual behaviors with the HPV carrier plays an important role in the transmission of this virus".
And, "The global incidence of head and neck cancers is declining, but the incidence of HPV related head and neck cancers is rapidly increasing over the last few decades".
Unfortunately, the doctor team continued, "However, most institutions do not mandate documentation of sexual history or counseling of patients regarding sexual practices like they do for tobacco and alcohol addictions in HNSCC patients".
The results strongly suggested that HPV can transmit and cause head and neck cancer.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural remedy for the treatment of head and neck cancer examined the two major pharmacologically active compounds of ginger, 6-gingerol, and 6-shogaol on head and neck cancer cell lines.
According to assays, injection of 6-gingerol, and 6-shogaol showed a dose-dependent reduction of cancer cell viability and induced cancer cells apoptosis.
Furthermore, according to the Western blot analysis, injection of ginger also suppressed the protein associated with the antiapoptotic activity, namely the survivin.
Combination of 6-shogaol with cisplatin also showed a synergistic reduction of clonogenic survival.
The results strongly suggested that ginger inhibits head and neck cancer cells through degradation and apoptosis.
Moreover, in order to reveal more information about ginger anti-cancer effects, researchers evaluated
the 1'-Acetoxychavicol acetate (ACA), extracted from rhizomes of tropical ginger against human head and neck squamous cell carcinoma cell line HN4.
Application of ACA exerted significantly inhibited activity against the growth of human head and neck squamous cell carcinoma cell line HN4 and induced cell apoptosis.
The efficacy of ACA was associated with the inhibition of the expression of miR-23a, which has been found to promote growth and suppress apoptosis in HN4 cells.
Under the transfection process, ginger demonstrated a strong anti-miR-23a activity by stimulating the inhibition of the proliferation of HN4 cells and inducing cell apoptosis.
Where miR-23a is an RNA gene which can repress tumor suppressor phosphatase and tensin homolog (PTEN) for the growth of the tumor.
Taken altogether, ginger processed major active compounds may be considered a functional remedy for the prevention and treatment of head and neck cancer, pending to the confirmation of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) 6-shogaol induces apoptosis and enhances radiosensitivity in head and necksquamous cell carcinoma cell lines by Kotowski U1, Kadletz L1, Schneider S1, Foki E1, Schmid R2, Seemann R3, Thurnher D4, Heiduschka G. (PubMed)
(2) MicroRNAs contribute to the anticancer effect of 1'-acetoxychavicol acetate in human head and neck squamous cell carcinoma cell line HN4 byWang H1, Shen L, Li X, Sun M. (PubMed)
(3) Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature by Ankit Shah, Akshat Malik, Apurva Garg, Manish Mair, Sudhir Nair, and Pankaj Chaturvedi. (BMJ Journal)
Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organ, leading to secondary metastasis.
The exact causes of head and neck cancer are unknown. However, certain risk factors have been found to associate with the onset of the disease, including, excessive alcohol intake, smoking, infected by the HPV virus, poor oral health, race, long-term exposure to wood dust.
Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.
According to the statistics, in the US, HPV is the most common sexually transmitted virus.
Dr. Ankit Shah, the lead scientist in the examination of oral sex and human papillomavirus-related head and neck squamous cell cancer, wrote, "Unprotected sexual behaviors with the HPV carrier plays an important role in the transmission of this virus".
And, "The global incidence of head and neck cancers is declining, but the incidence of HPV related head and neck cancers is rapidly increasing over the last few decades".
Unfortunately, the doctor team continued, "However, most institutions do not mandate documentation of sexual history or counseling of patients regarding sexual practices like they do for tobacco and alcohol addictions in HNSCC patients".
The results strongly suggested that HPV can transmit and cause head and neck cancer.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural remedy for the treatment of head and neck cancer examined the two major pharmacologically active compounds of ginger, 6-gingerol, and 6-shogaol on head and neck cancer cell lines.
According to assays, injection of 6-gingerol, and 6-shogaol showed a dose-dependent reduction of cancer cell viability and induced cancer cells apoptosis.
Furthermore, according to the Western blot analysis, injection of ginger also suppressed the protein associated with the antiapoptotic activity, namely the survivin.
Combination of 6-shogaol with cisplatin also showed a synergistic reduction of clonogenic survival.
The results strongly suggested that ginger inhibits head and neck cancer cells through degradation and apoptosis.
Moreover, in order to reveal more information about ginger anti-cancer effects, researchers evaluated
the 1'-Acetoxychavicol acetate (ACA), extracted from rhizomes of tropical ginger against human head and neck squamous cell carcinoma cell line HN4.
Application of ACA exerted significantly inhibited activity against the growth of human head and neck squamous cell carcinoma cell line HN4 and induced cell apoptosis.
The efficacy of ACA was associated with the inhibition of the expression of miR-23a, which has been found to promote growth and suppress apoptosis in HN4 cells.
Under the transfection process, ginger demonstrated a strong anti-miR-23a activity by stimulating the inhibition of the proliferation of HN4 cells and inducing cell apoptosis.
Where miR-23a is an RNA gene which can repress tumor suppressor phosphatase and tensin homolog (PTEN) for the growth of the tumor.
Taken altogether, ginger processed major active compounds may be considered a functional remedy for the prevention and treatment of head and neck cancer, pending to the confirmation of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) 6-shogaol induces apoptosis and enhances radiosensitivity in head and necksquamous cell carcinoma cell lines by Kotowski U1, Kadletz L1, Schneider S1, Foki E1, Schmid R2, Seemann R3, Thurnher D4, Heiduschka G. (PubMed)
(2) MicroRNAs contribute to the anticancer effect of 1'-acetoxychavicol acetate in human head and neck squamous cell carcinoma cell line HN4 byWang H1, Shen L, Li X, Sun M. (PubMed)
(3) Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature by Ankit Shah, Akshat Malik, Apurva Garg, Manish Mair, Sudhir Nair, and Pankaj Chaturvedi. (BMJ Journal)
Bioactive Compound 3,3'-Diindolylmethane Protects the Neurons Integrityand Viability Against Autoimmune Encephalomyelitis
Autoimmune encephalitis is a group of conditions caused by the body's immune system mistakenly attacks healthy brain cells.
Autoimmune encephalitis has been found to induce neurologic symptoms such as impaired memory and cognition, abnormal movements, seizures, and/or psychiatric symptoms such as aggression, inappropriate sexual behaviors, panic attacks.
Autoimmune encephalitis can be classified into
* Post-infectious encephalitis or acute disseminated encephalomyelitis (ADEM) are the conditions caused by an infection. In these cases, the immune system not only attacks the pathogens which cause infection it also destroys mistakenly the healthy cells in the brain.
Methylprednisolone is the first line of drug for the treatment of post-infectious encephalitis, if it failures, plasma exchange or intravenous immunoglobulin may be used.
* Other forms of autoimmune encephalitis are caused by the specific antibodies in the blood produced by the immune system that attack the brain cells.
According to the Autoimmune Encephalitis Alliance, a number of options are available to treat AE, the first line option include including medication that decreases the inflammatory response to antibodies, and intravenous immunoglobulin (IVIG); to increase removal of antibodies, inhibit binding of the harmful antibodies.
If the first line option failure, immune suppressive medicine may be used as a second line of treatment, including Rituximab, CellCept, and Cytoxan (Cyclophosphamide).
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
With an aim to find a potential ingredient for the treatment of autoimmune encephalomyelitis, researchers evaluated the 3,3'-Diindolylmethane (DIM) effects on the regulation of activated T cells during the development of experimental autoimmune encephalomyelitis (EAE).
During the experiment, administration of DIM 10 days after EAE was effective in ameliorating disease parameters, including inflammation and central nervous system cellular infiltration.
According to the microRNA (miRNA) microarray analysis, post-treatment of DIM alter the expression of miRNA profile in brain infiltrating CD4(+) T cells, an indication of autoimmune dysfunction on EAE mice.
Observed by the bioinformatics analysis, the efficacy of DIM-altered the miRNAs expression associated with pathways that halt cell cycle progression and promote apoptosis.
Particularly, DIM impacted these cellular processes in activated T cells.
More precisely, DIM protected the brain against the immune dysfunction in attacking the brain cell in the forming of autoimmune encephalomyelitis, by activating and suppressing the micro genes- induced immune dysfunction of EAE.
Dr. the lead scientist, after taking into account co and confounders wrote, "these studies demonstrate that DIM post-treatment leads to the amelioration of EAE development by suppressing T-cell responses through the induction of select miRNAs that control cell cycle progression and mediate apoptosis".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of autoimmune encephalomyelitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways by Rouse M1, Rao R1, Nagarkatti M1, Nagarkatti PS. (PubMed)
(2) Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells by Rouse M1, Singh NP, Nagarkatti PS, Nagarkatti M. (PubMed)
Autoimmune encephalitis has been found to induce neurologic symptoms such as impaired memory and cognition, abnormal movements, seizures, and/or psychiatric symptoms such as aggression, inappropriate sexual behaviors, panic attacks.
Autoimmune encephalitis can be classified into
* Post-infectious encephalitis or acute disseminated encephalomyelitis (ADEM) are the conditions caused by an infection. In these cases, the immune system not only attacks the pathogens which cause infection it also destroys mistakenly the healthy cells in the brain.
Methylprednisolone is the first line of drug for the treatment of post-infectious encephalitis, if it failures, plasma exchange or intravenous immunoglobulin may be used.
* Other forms of autoimmune encephalitis are caused by the specific antibodies in the blood produced by the immune system that attack the brain cells.
According to the Autoimmune Encephalitis Alliance, a number of options are available to treat AE, the first line option include including medication that decreases the inflammatory response to antibodies, and intravenous immunoglobulin (IVIG); to increase removal of antibodies, inhibit binding of the harmful antibodies.
If the first line option failure, immune suppressive medicine may be used as a second line of treatment, including Rituximab, CellCept, and Cytoxan (Cyclophosphamide).
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
With an aim to find a potential ingredient for the treatment of autoimmune encephalomyelitis, researchers evaluated the 3,3'-Diindolylmethane (DIM) effects on the regulation of activated T cells during the development of experimental autoimmune encephalomyelitis (EAE).
During the experiment, administration of DIM 10 days after EAE was effective in ameliorating disease parameters, including inflammation and central nervous system cellular infiltration.
According to the microRNA (miRNA) microarray analysis, post-treatment of DIM alter the expression of miRNA profile in brain infiltrating CD4(+) T cells, an indication of autoimmune dysfunction on EAE mice.
Observed by the bioinformatics analysis, the efficacy of DIM-altered the miRNAs expression associated with pathways that halt cell cycle progression and promote apoptosis.
Particularly, DIM impacted these cellular processes in activated T cells.
More precisely, DIM protected the brain against the immune dysfunction in attacking the brain cell in the forming of autoimmune encephalomyelitis, by activating and suppressing the micro genes- induced immune dysfunction of EAE.
Dr. the lead scientist, after taking into account co and confounders wrote, "these studies demonstrate that DIM post-treatment leads to the amelioration of EAE development by suppressing T-cell responses through the induction of select miRNAs that control cell cycle progression and mediate apoptosis".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of autoimmune encephalomyelitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways by Rouse M1, Rao R1, Nagarkatti M1, Nagarkatti PS. (PubMed)
(2) Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells by Rouse M1, Singh NP, Nagarkatti PS, Nagarkatti M. (PubMed)
Plant-based Chemical Betanin Kills Cancer Cells in Vitro
Cancer is the class of diseases associated with cell growth, disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved the onset of cancer.
However, most people with some of the aforementioned risk factors have never developed cancer.
Some researchers suggested that the rise of cancers in the obese individual may correlate to the promotion of the Western diet over the past few decades.
Dr.Timothy J Key, the lead scientist wrote, "Diet-related factors are thought to account for about 30% of cancers in developed countries. Obesity increases the risk of cancers in the esophagus, colorectum, breast, endometrium, and kidney. Alcohol causes cancers of the oral cavity, pharynx, larynx, esophagus, and liver, and causes a small increase in the risk of breast cancer".
And, "Adequate intakes of fruit and vegetables probably lower the risk for several types of cancer, especially cancers of the gastrointestinal tract".
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a natural ingredient which reduces the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues, researchers examined betanin (BET) effect in the co-administration with them.
In the study to overcome the restrictions of BET, researchers designed a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) for the DOX and BET loading capacity of 20.5% and 16.25%, respectively).
Injection of DOX@BET loaded PGNPs decreased the significant cell viability amount of breast cancer cells (MCF-7) compared to the treatment of the free form of DOX or BET.
In other words, the newly designed combination kills induce a higher percentage of cell death compared to the use of DOX or BET individually.
Sadly, the study did not confirm the combination reduced the side effect caused by DOX during the experiment.
Dr. Javadi B in the examination of herbal plants for the treatment of breast cancer showed that beetroot (Beta vulgris) induced cancer death by cytotoxicity without affecting the nearby healthy cells.
He continued, "additional pharmacological studies and clinical trials are needed to elucidate their molecular and cellular mechanisms of actions, frequency, and amount of consumption, possible adverse effects, and optimum preparation methods.".
Taken altogether, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine by Javadi B. (PubMed)
(3) The effect of diet on risk of cancer by Dr. Timothy J Key, Naomi E Allen, Elizabeth A Spencer,
Ruth C Travis. (The Lancet)
Most cases of cancer begin in the cells on the surface of the inner lining tissues of organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved the onset of cancer.
However, most people with some of the aforementioned risk factors have never developed cancer.
Some researchers suggested that the rise of cancers in the obese individual may correlate to the promotion of the Western diet over the past few decades.
Dr.Timothy J Key, the lead scientist wrote, "Diet-related factors are thought to account for about 30% of cancers in developed countries. Obesity increases the risk of cancers in the esophagus, colorectum, breast, endometrium, and kidney. Alcohol causes cancers of the oral cavity, pharynx, larynx, esophagus, and liver, and causes a small increase in the risk of breast cancer".
And, "Adequate intakes of fruit and vegetables probably lower the risk for several types of cancer, especially cancers of the gastrointestinal tract".
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a natural ingredient which reduces the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues, researchers examined betanin (BET) effect in the co-administration with them.
In the study to overcome the restrictions of BET, researchers designed a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) for the DOX and BET loading capacity of 20.5% and 16.25%, respectively).
Injection of DOX@BET loaded PGNPs decreased the significant cell viability amount of breast cancer cells (MCF-7) compared to the treatment of the free form of DOX or BET.
In other words, the newly designed combination kills induce a higher percentage of cell death compared to the use of DOX or BET individually.
Sadly, the study did not confirm the combination reduced the side effect caused by DOX during the experiment.
Dr. Javadi B in the examination of herbal plants for the treatment of breast cancer showed that beetroot (Beta vulgris) induced cancer death by cytotoxicity without affecting the nearby healthy cells.
He continued, "additional pharmacological studies and clinical trials are needed to elucidate their molecular and cellular mechanisms of actions, frequency, and amount of consumption, possible adverse effects, and optimum preparation methods.".
Taken altogether, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine by Javadi B. (PubMed)
(3) The effect of diet on risk of cancer by Dr. Timothy J Key, Naomi E Allen, Elizabeth A Spencer,
Ruth C Travis. (The Lancet)
Cucumbers (Cucumis sativus) Bioactive Compound Cucurbitacin B (CuB) Kills Melanoma in Vitro
Melanoma is a type of skin cancer associated with the alternation of DNA in the pigment-containing cells.
The melanin is a pigment that gives skin, hair, and eyes their color.
Malignant melanin cells (melanocytes) lead to the formation of moles on the skin with usually brown or pink color.
Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body in cases the kidney and liver fail.
Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light color skin, personal and family history of skin cancer are associated with the onset melanoma.
However, most people with some of the aforementioned risk factors have not developed melanoma.
Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.
Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, have been identified as a risk factor for the development of melanoma".
And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".
Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cell.
According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration and invasion potential of the melanoma cells.
In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to control.
Furthermore, injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.
Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved the formation of microfilaments.
Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".
Additonally, CuB inhibited the proliferation of the cell line was found to be in a dose-dependent manner, involving the induction of autophagy and exhibited the function of a protein associated with anti-apoptosis.
Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitive to the tested melanoma cells.
In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine side effects.
Taken altogether, cucumber processed a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending to the confirmation of larger sample size and multicenter human study
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)
The melanin is a pigment that gives skin, hair, and eyes their color.
Malignant melanin cells (melanocytes) lead to the formation of moles on the skin with usually brown or pink color.
Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body in cases the kidney and liver fail.
Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light color skin, personal and family history of skin cancer are associated with the onset melanoma.
However, most people with some of the aforementioned risk factors have not developed melanoma.
Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.
Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, have been identified as a risk factor for the development of melanoma".
And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".
Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cell.
According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration and invasion potential of the melanoma cells.
In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to control.
Furthermore, injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.
Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved the formation of microfilaments.
Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".
Additonally, CuB inhibited the proliferation of the cell line was found to be in a dose-dependent manner, involving the induction of autophagy and exhibited the function of a protein associated with anti-apoptosis.
Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitive to the tested melanoma cells.
In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine side effects.
Taken altogether, cucumber processed a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending to the confirmation of larger sample size and multicenter human study
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)
Thursday, May 9, 2019
Tomato Improves Sleep Quality by Enhancing Levels of Melatonin
In other words, sleep is the state in which human reduced interactions with the outside world.
The human sleep recurrently to reenergize their body so that when awake they can carry out a daily activity without feeling tired or weak.
In the brain, sleep helps to maintain the pathways associated with the brain function such as learning and studying. A recent study suggested, sleep helps to remove toxins in the brain that was built up when awake.
Believe it or not, we spend about one-third of our life sleeping.
Sleep disorders are syndromes associated negatively with the changes in the sleep pattern, including insomnia, one of the most common causes of disease disorders in the US, found in 30% of adults, including 10% of chronic insomnia is a condition of difficulty falling asleep or staying asleep throughout the night.
According to the statistics, 50-70 million US adults have a sleep disorder including 37.9% reported unintentionally falling asleep during the day.
Sleep disorders have been found to have a strong implication on economic cost. Dr. Hillman DR, the lead scientist at the Sir Charles Gairdner Hospital wrote, "The overall cost of sleep disorders in Australia in 2004 (population: 20.1 million) was dollar 7494 million".
And, "The direct and indirect costs of sleep disorders are high. The total financial costs (independent of the cost of suffering) of dollar 4524 million represents 0.8% of Australian gross domestic product. The cost of suffering of dollar 2970 million is 1.4% of the total burden of disease in Australia".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a natural and potential compound for the improvement of sleep quality, researchers investigated the effect of tomato intake before bed on obese postmenopausal women's urinary 6-sulphatoxymelatonin (aMT6s) level, a reliable surrogate biomarker reflecting the blood melatonin concentration and sleep quality.
The study is an 8-week open-label, randomized controlled dietary intervention trial included 36 subjects completed the entire trial.
In the tomato group, participants ate 250 g of beefsteak tomatoes 2 h before sleep for 8 weeks.
After 8 weeks, by comparing the blood and urine samples collected at the baseline and in the 8th week, researchers found at 8 weeks of the beefsteak intervention, improved all components of all components the PSQI compared to the Pittsburgh Sleep Quality Index (PSQI) before treatment.
Furthermore, tomatoes and beefsteak intervention also improved the levels of aMT6s level by 10-fold compared that of the control group.
In other words, tomato combined with beefsteak improved the sleep quality of the participants.
These results strongly suggested that tomato enhanced the levels of melatonin in the beef substantially in the improvement of sleep quality.
Dr. Yang TH, the lead scientist at the Taipei Medical University wrote in the final report, "supplementation with beefsteak tomato before sleep can increase circulating melatonin and improve sleep quality in obese postmenopausal women".
Taken altogether, tomatoes combined with beefsteak may be considered treatment to improve sleep quality, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary supplement of tomato can accelerate urinary aMT6s level and improve sleep quality in obese postmenopausal women by Yang TH1, Chen YC1, Ou TH1, Chien YW. (PubMed)
(2) The economic cost of sleep disorders by Hillman DR1, Murphy AS, Pezzullo L. (PubMed)
Herbal Ginger, the Potential Anti Hyperlipidemia Functional Remedy, Researchers Find
Hyperlipidemia is abnormally high levels of cholesterol in the bloodstream. The syndrome is a member of the cluster conditions of metabolic syndrome, a leading cause of cardiovascular disease.
Cholesterol, a waxy substance produced either by the liver or food intake plays a critical role in the production of vitamin D, steroid hormones and the building of the cell walls.
Overexpression cholesterol is a medical condition which causes plaque accumulated on the arterial wall, leading to narrowing the arteries in transport the oxygenated blood to the parts of the body.
In severe cases, it can cause blood flow blockage, leading to chronic ailments depending on the location of the blood clot.
There are 2 types of blood cholesterol, the low-density lipoprotein (LDL) which carries the aforementioned functions and the high-density cholesterol (HDL) which carries cholesterol from the blood back to the liver for the future re-use.
The healthy ratio of total blood cholesterol is less than 4 LDL/ 1 HDL.
Most people diagnosed with high blood cholesterol substantially higher total cholesterol ratio.
Some researchers suggested that the widespread high blood cholesterol in North America is associated with the promotion of the Western diet over the past few decades.
Dr. Kamilah Ali, the lead scientist in the assessment of the Western diet risk of high blood cholesterol in an animal model, wrote, "mice on a C57BL/6 background after receiving a high fat-high cholesterol diet for 12 weeks. ApoD−/− mice had higher HDL-cholesterol levels (61±13-apoD−/− vs. 52±10-WT-males; 37±11-apoD−/− vs. 22±2 WT-female) than WT mice with sex-specific changes in total plasma levels of cholesterol and other lipids".
And, "Compared to WT, the HDL of apoD−/− mice showed an increase in large, lipid-rich HDL particles and according to size various quantities and sizes of LDL particles".
The results suggested that long-term users of the Western diet may be associated with the risk of hyperlipidemia.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the trerament dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of hyperlipidemia investigated the effect of ginger extracts on alcohol-induced hyperlipidemia and associated myocardial damage.
The study included 24 Wistar male albino rats (250 ± 20 g) divided into four groups including, normal control (NC) (0.9% NaCl), ginger treated (Gt) (200 mg/Kg b.w.), alcohol-treated (At) (20% of 6g/kg b.w. alcohol), and alcohol along with Ginger treatment (At+Gt).
Before ginger administration, alcohol-induced myocardial damage rats showed an increased lipid profile except for high-density lipoprotein compared with control.
Ginger treatment significantly inhibited the alcohol-induced lipid profiles caused by the injection of alcohol except for high-density lipoproteins.
Furthermore, ginger treatment also inhibited the elevated cardiac biomarkers activity with alcohol intoxication. In other words, ginger treatment for 7-weeks significantly minimized the alcohol-induced myocardial damage.
Dr. Subbaiah GV, the lead scientist said, "ginger could protect alcohol-induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers".
In order to reveal more information about ginger anti hypolipidemic effects, researchers examined the hypolipidemic effects of a hydroethanolic ginger extract (GE) in the liver of rats fed a high-fat diet (HFD).
The study included male Wistar rats divided into the following 3 groups: (i) Rats fed a standard diet (3.5% fat), the control group; (ii) rats fed an HFD (33.5% fat); and (iii) rats fed an HFD treated with GE (250 mg·kg-1·day-1) for 5 weeks (HFD+GE).
GE improved lipid profile and attenuated the increase of plasma levels of glucose, insulin, and leptin in HFD rats.
In the depth analysis, researchers found that ginger antihyperlipidemic activity was attributed to the induction of a higher liver expression of proteins associated with a variety of metabolic processes including lipid and enhanced levels of adiponectin which plays a critical role in preventing dyslipidemia.
Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of hyperlipidemia with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Ginger Treatment Ameliorates Alcohol-induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats by Subbaiah GV1, Mallikarjuna K2, Shanmugam B1, Ravi S1, Taj PU1, Reddy KS1. (PubMed)
(2) Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet by de Las Heras N1, Valero-Muñoz M1, Martín-Fernández B1, Ballesteros S1, López-Farré A2, Ruiz-Roso B3, Lahera V1. (PubMed)
(3) A Western-Fed Diet Increases Plasma HDL and LDL-Cholesterol Levels in ApoD–/– Mice by Kamilah Ali, Ehab M. Abo-Ali, M. D. Kabir, 1 Bethany Riggins, 1 Susanna Nguy, 1Lisa Li, 1 Ujala Srivastava, 1 and Su Mya Mya Thinn. (PMC)
Cholesterol, a waxy substance produced either by the liver or food intake plays a critical role in the production of vitamin D, steroid hormones and the building of the cell walls.
Overexpression cholesterol is a medical condition which causes plaque accumulated on the arterial wall, leading to narrowing the arteries in transport the oxygenated blood to the parts of the body.
In severe cases, it can cause blood flow blockage, leading to chronic ailments depending on the location of the blood clot.
There are 2 types of blood cholesterol, the low-density lipoprotein (LDL) which carries the aforementioned functions and the high-density cholesterol (HDL) which carries cholesterol from the blood back to the liver for the future re-use.
The healthy ratio of total blood cholesterol is less than 4 LDL/ 1 HDL.
Most people diagnosed with high blood cholesterol substantially higher total cholesterol ratio.
Some researchers suggested that the widespread high blood cholesterol in North America is associated with the promotion of the Western diet over the past few decades.
Dr. Kamilah Ali, the lead scientist in the assessment of the Western diet risk of high blood cholesterol in an animal model, wrote, "mice on a C57BL/6 background after receiving a high fat-high cholesterol diet for 12 weeks. ApoD−/− mice had higher HDL-cholesterol levels (61±13-apoD−/− vs. 52±10-WT-males; 37±11-apoD−/− vs. 22±2 WT-female) than WT mice with sex-specific changes in total plasma levels of cholesterol and other lipids".
And, "Compared to WT, the HDL of apoD−/− mice showed an increase in large, lipid-rich HDL particles and according to size various quantities and sizes of LDL particles".
The results suggested that long-term users of the Western diet may be associated with the risk of hyperlipidemia.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the trerament dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of hyperlipidemia investigated the effect of ginger extracts on alcohol-induced hyperlipidemia and associated myocardial damage.
The study included 24 Wistar male albino rats (250 ± 20 g) divided into four groups including, normal control (NC) (0.9% NaCl), ginger treated (Gt) (200 mg/Kg b.w.), alcohol-treated (At) (20% of 6g/kg b.w. alcohol), and alcohol along with Ginger treatment (At+Gt).
Before ginger administration, alcohol-induced myocardial damage rats showed an increased lipid profile except for high-density lipoprotein compared with control.
Ginger treatment significantly inhibited the alcohol-induced lipid profiles caused by the injection of alcohol except for high-density lipoproteins.
Furthermore, ginger treatment also inhibited the elevated cardiac biomarkers activity with alcohol intoxication. In other words, ginger treatment for 7-weeks significantly minimized the alcohol-induced myocardial damage.
Dr. Subbaiah GV, the lead scientist said, "ginger could protect alcohol-induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers".
In order to reveal more information about ginger anti hypolipidemic effects, researchers examined the hypolipidemic effects of a hydroethanolic ginger extract (GE) in the liver of rats fed a high-fat diet (HFD).
The study included male Wistar rats divided into the following 3 groups: (i) Rats fed a standard diet (3.5% fat), the control group; (ii) rats fed an HFD (33.5% fat); and (iii) rats fed an HFD treated with GE (250 mg·kg-1·day-1) for 5 weeks (HFD+GE).
GE improved lipid profile and attenuated the increase of plasma levels of glucose, insulin, and leptin in HFD rats.
In the depth analysis, researchers found that ginger antihyperlipidemic activity was attributed to the induction of a higher liver expression of proteins associated with a variety of metabolic processes including lipid and enhanced levels of adiponectin which plays a critical role in preventing dyslipidemia.
Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of hyperlipidemia with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Ginger Treatment Ameliorates Alcohol-induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats by Subbaiah GV1, Mallikarjuna K2, Shanmugam B1, Ravi S1, Taj PU1, Reddy KS1. (PubMed)
(2) Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet by de Las Heras N1, Valero-Muñoz M1, Martín-Fernández B1, Ballesteros S1, López-Farré A2, Ruiz-Roso B3, Lahera V1. (PubMed)
(3) A Western-Fed Diet Increases Plasma HDL and LDL-Cholesterol Levels in ApoD–/– Mice by Kamilah Ali, Ehab M. Abo-Ali, M. D. Kabir, 1 Bethany Riggins, 1 Susanna Nguy, 1Lisa Li, 1 Ujala Srivastava, 1 and Su Mya Mya Thinn. (PMC)
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