Obesity is a progressive chronic disease, associated with abnormal or excessive fat accumulation in the body.
People who have a BMI of over 30 is considered to be obese.
According to the statistics provided by Obesity Cabada, the rate of obesity has increased at an alarming rate in Canada over the past few decades.
Approximately over 30% of Canadian adults are considered obese that may require medical support to manage their disease.
Epidemiologically, type 2 diabetes, high blood pressure, heart disease, stroke, arthritis, cancer and other major health problems have been found in most obese patients, causing concern to the scientist community in the health care system.
Believe it or not, obesity has been found contributing to one 10 premature deaths among Canadian adults age 20 to 64. As of today, the health care system in Canada has spent between $5 billion and $7 billion for the treatment of obese related complications.
Furthermore, obesity is associated with increased mortality and a number of complications including diabetes, heart disease, dementia, and cancer.
And, the commitment of reduced weight through a healthy diet accompanied by moderate exercise has been proposed to target the complications.
Out of many risk factors associated with the onset of obesity, the social economy may have some implication involved in the onset of the disease.
Dr. BRIAN HOULE, wrote in the article "How Obesity Relates to Socioeconomic Status" "...obesity rose with a nation’s economic development, but also that socioeconomic status as it related to obesity changed. In lower-income countries, people with higher SES were more likely to be obese. Conversely, in high-income countries, those with higher SES were less likely to be obese".
And, "Why the reversal? It may be that in lower-income countries, higher SES leads to consuming high-calorie food and avoiding physically tough tasks. But in higher-income countries, individuals with higher SES may respond with healthy eating and regular exercise".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a natural and potential compound for the treatment of obesity, researchers review the link of high intake of lycopene or tomatoes products in the risk for metabolic diseases by comparing the effect of lycopene and tomato powder on obesity-associated disorders.
The study included selected Male C57BL/J6 mice randomly assigned into four groups to receive: control diet (Chigh-fat fat diet (HFD), high fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks.
In mice treated with HFD, lycopene and TP supplementation significantly improve the obese complications caused by adiposity index, organ, and relative organ weights, serum triglycerides, free fatty acids.
Furthermore, lycopene and TP supplementation also 8-iso-prostaglandin GF2α associated with an increased risk of heart disease and improved glucose homeostasis, against the onset of abnormal blood glucose.
Furthermore, Lycopene and TP supplementation prevented HFD-induced hepatosteatosis and hypertrophy of adipocytes associated with patients of obesity.
Moreover, lycopene and TP also decreased HFD-induced the production of proinflammatory cytokines in the liver and in the epididymal adipose tissue found in obese subjects.
According to the tested assay, lycopene and TP anti-inflammatory effects were attributed to the inhibition of the protein involved promotion of the expression of inflammation in adipose tissue.
Based on the findings, lycopene, and TP protected significantly obese subjects against the onset of obesity complications.
Dr. Fenni S after taking other factors into account wrote, "These results suggest that lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies".
Taken altogether, tomatoes processed a high amount of lycopene may be considered whole food for the prevention and treatment of diseases associated with obesity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders by Fenni S1,2, Hammou H2, Astier J1, Bonnet L1, Karkeni E1, Couturier C1, Tourniaire F1, Landrier JF. (PubMed)
Sunday, May 12, 2019
Cucumbers (Cucumis sativus), the Potential Anti-Pancreatic Cancer Functional Food
Primary pancreatic cancer is a medical condition originated from the pancreas as a result of the alternation of cells DNA in the pancreas tissue.
Most cases of pancreatic cancer at the early stage begin in the cell on the surface of the inner lining of the pancreas before growing in the size that affects the function of the organ.
At the very early stage of the pancreas, most patients are asymptomatic. However, at the advanced stage, patients may experience the symptoms shared by all cancers such as unintended weight loss, loss of appetite, persistent fatigue and gastrointestinal discomforts accompanied by jaundice, belly and back pain, enlarged liver and gallbladder and blood clot.
According to the statistics provided by the American Cancer Society, in the US this year, approximately 56,770 people (29,940 men and 26,830 women) will be diagnosed with pancreatic cancer. The disease also will cause the death of 45,750 people (23,800 men and 21,950 women) in the US.
The 5 years survival rate of localized pancreatic cancer is only 34%. The rate is relatively low compared to other types of cancer in the localized stage such as 100% in breast cancer.
The causes of pancreatic cancer are unknown. Epidemiological studies suggested that aging, gender, ethnicity, family history, smoking, people with certain medical con conditions as diabetes, are the most prevalent risk found in patients with pancreatic cancer.
Dr. Michaud DS in the examination of the rate of pancreatic cancer risk arisen in patients with obesity compared to overweight and healthy subjects over past few decades wrote, "Obesity has surfaced as an important risk factor for pancreatic cancer as epidemiological studies with strong methodological designs have removed important biases and solidified the obesity associations".
And, "Moreover, studies indicate that obesity early in adulthood is strongly associated with future risk of pancreatic cancer and that abdominal obesity is an independent risk factor".
Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
In the urgency to find a potential compound for the treatment of pancreatic cancer, researchers examined the Cucurbitacin B (CuB), a natural tetracyclic triterpene product found abundantly in cucumber antitumor activity.
According to the tested assays, CuB arrested pancreatic cancer (PC) cells in the G2/M cell cycle phase by suppressing the expression of AFAP1-AS1, an RNA gene associated with poor prognosis in cancer patients.
Elevated AFAP1-AS1 expression is found in patients' TSCC tumor tissues and tested cell lines.
Additional differentiation of the CuB effects, researchers found that Cub suppression the tumor proliferation by enhancing high miR-146b-5p expression in pancreatic cancer (PC) cells, an indication of cancer cells suppression.
Based on the findings, researchers said, "CuB suppresses the proliferation, in vitro and in vivo, of PC cells through the... effect of AFAP1-AS1 on miR-146b-5p".
Additionally, according to the results from the Shengjing Hospital of China Medical University,* CuB inhibited of the expression of epidermal growth factor receptor (EGFR) in the promotion of solid tumor growth.
* CuB blocked the activation of signaling pathways (PI3K/Akt/mTOR and STAT3.) associated with the cell proliferative stimulation.
* CuB also exhibited cytotoxicity by enhancing t
The protein (ERK-activating AMPK signaling) associated with cellular metabolism and tumor suppression
Taken altogether, cucumber processed abundantly bioactive compound CuB may be considered a functional food for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR-146b-5p and lncRNA-AFAP1-AS by Zhou J1, Liu M2, Chen Y1, Xu S1, Guo Y3, Zhao L. (PubMed)
(2) Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic canceractivities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling by Zhou J1, Zhao T2, Ma L2, Liang M2, Guo YJ2, Zhao LM. (PubMed)
(3) Obesity and Pancreatic Cancer by Michaud DS. (PubMed)
Most cases of pancreatic cancer at the early stage begin in the cell on the surface of the inner lining of the pancreas before growing in the size that affects the function of the organ.
At the very early stage of the pancreas, most patients are asymptomatic. However, at the advanced stage, patients may experience the symptoms shared by all cancers such as unintended weight loss, loss of appetite, persistent fatigue and gastrointestinal discomforts accompanied by jaundice, belly and back pain, enlarged liver and gallbladder and blood clot.
According to the statistics provided by the American Cancer Society, in the US this year, approximately 56,770 people (29,940 men and 26,830 women) will be diagnosed with pancreatic cancer. The disease also will cause the death of 45,750 people (23,800 men and 21,950 women) in the US.
The 5 years survival rate of localized pancreatic cancer is only 34%. The rate is relatively low compared to other types of cancer in the localized stage such as 100% in breast cancer.
The causes of pancreatic cancer are unknown. Epidemiological studies suggested that aging, gender, ethnicity, family history, smoking, people with certain medical con conditions as diabetes, are the most prevalent risk found in patients with pancreatic cancer.
Dr. Michaud DS in the examination of the rate of pancreatic cancer risk arisen in patients with obesity compared to overweight and healthy subjects over past few decades wrote, "Obesity has surfaced as an important risk factor for pancreatic cancer as epidemiological studies with strong methodological designs have removed important biases and solidified the obesity associations".
And, "Moreover, studies indicate that obesity early in adulthood is strongly associated with future risk of pancreatic cancer and that abdominal obesity is an independent risk factor".
Cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
In the urgency to find a potential compound for the treatment of pancreatic cancer, researchers examined the Cucurbitacin B (CuB), a natural tetracyclic triterpene product found abundantly in cucumber antitumor activity.
According to the tested assays, CuB arrested pancreatic cancer (PC) cells in the G2/M cell cycle phase by suppressing the expression of AFAP1-AS1, an RNA gene associated with poor prognosis in cancer patients.
Elevated AFAP1-AS1 expression is found in patients' TSCC tumor tissues and tested cell lines.
Additional differentiation of the CuB effects, researchers found that Cub suppression the tumor proliferation by enhancing high miR-146b-5p expression in pancreatic cancer (PC) cells, an indication of cancer cells suppression.
Based on the findings, researchers said, "CuB suppresses the proliferation, in vitro and in vivo, of PC cells through the... effect of AFAP1-AS1 on miR-146b-5p".
Additionally, according to the results from the Shengjing Hospital of China Medical University,* CuB inhibited of the expression of epidermal growth factor receptor (EGFR) in the promotion of solid tumor growth.
* CuB blocked the activation of signaling pathways (PI3K/Akt/mTOR and STAT3.) associated with the cell proliferative stimulation.
* CuB also exhibited cytotoxicity by enhancing t
The protein (ERK-activating AMPK signaling) associated with cellular metabolism and tumor suppression
Taken altogether, cucumber processed abundantly bioactive compound CuB may be considered a functional food for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B suppresses proliferation of pancreatic cancer cells by ceRNA: Effect of miR-146b-5p and lncRNA-AFAP1-AS by Zhou J1, Liu M2, Chen Y1, Xu S1, Guo Y3, Zhao L. (PubMed)
(2) Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic canceractivities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling by Zhou J1, Zhao T2, Ma L2, Liang M2, Guo YJ2, Zhao LM. (PubMed)
(3) Obesity and Pancreatic Cancer by Michaud DS. (PubMed)
Saturday, May 11, 2019
The Natural Herbal Remedies for the Treatment of Non Alcoholic Liver Fatty Disease, Scientists Say
Nonalcoholic fatty liver disease (NAFLD) is a chronic condition caused by fat accumulated in the liver over time, in the absence of excessive alcohol use. The disease can be classified into the types of non-inflammatory fatty liver (NAFl) and inflammatory nonalcoholic steatohepatitis (NASH)(1).
Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer.
According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease of the Western world(2). However, due to the economic prosperity of Southeast Asian(3), the disease also was found in a large number of population in the cities, causing concerns of many scientists in the region(4)(6).
According to the joint assessment of the prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the US, led by the Stanford University School of Medicine, "The prevalence of NAFLD in the United States (U.S.) has risen from 18% in 1988–1991 to 31% in 2011–2012. Estimates of NAFLD prevalence for adults in Western countries is 20–30%, with much higher prevalence in adults with obesity (80–90%), diabetes (30–50%), and hyperlipidemia (90%)"(5).
Among the more affluent regions of China, the prevalence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 15%(6). The number may decrease substantially if the poor rural populations where obesity is non-existence are also taking into account(7).
The exact causes of NAFLD aren't well understood. Some researchers suggested that certain risk factors such as long-term use of certain medications(8), genetic preposition(8), insulin resistance(8), high cholesterol(8) and triglycerides(8) in the blood, polycystic ovary syndrome(8), metabolic syndrome(8), obesity(8), and type 2 diabetes(8) are associated with the onset of the disease.
Recent studies also found that people with obstructive sleep apnea(11), underactive thyroid (hypothyroidism(10) and underactive pituitary gland (hypopituitarism) (9) also at an increased risk of the NALFD.
Some researchers suggested that unhealthy diet such as high-fat diet may also have a strong implication on NAFLD(12)(13).
Dr. Jensen VS, the lead scientist in the study high-fat diet-induced non-alcoholic fatty liver disease, wrote, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol has been linked to the development of non-alcoholic fatty liver disease (NAFLD)"(13).
And, " Only HFr-fed rats developed dyslipidemia as characterized by higher levels of plasma triglycerides compared to all other groups (p < 0.0001). Hepatic dysfunction and inflammation was confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control"(13).
According to the statistics, in the US, over 100 million people have non-alcoholic fatty liver disease and the condition is more double over the past 20 years(14). The disease also is the most prevalent liver disease in children(14).
The prevalence rate of NAFLD is varied among different ethnic groups in the US. Dr. Rich NE, the lead scientist in the investigation of the ethnicity and NAFLD, wrote, "NAFLD prevalence was highest in Hispanics, intermediate in Whites, and lowest in Blacks, although differences between groups were smaller in high-risk cohorts (range 47.6%-55.5%) than population-based cohorts (range, 13.0%-22.9%)(15)".
And, "Among patients with NAFLD, the risk of NASH was higher in Hispanics (relative risk, 1.09; 95% CI, 0.98-1.21) and lower in Blacks (relative risk, 0.72; 95% CI, 0.60-0.87) than Whites"(15).
The progression of NAFLD and NASH led to cirrhosis, the late stage of liver scarring are well defined, as the liver tries to heal itself by halting inflammation(16), leading to symptoms of ascites(16)(18), swell esophageal varices(16)(19), hepatic encephalopathy(16)(17) and complications of liver cancer(16)(17) and liver failure(16)(17).
Most people at the early stage NAFLD are asymptomatic, however, as the disease progression into the later stage, most patients experience symptoms of right upper abdominal discomfort(20), fatigue(20), and/or malaise(20), and jaundice(20) with yellowing of the skin and eyes(20).
Most patients with NAFLD have elevated levels of liver enzymes gamma-glutamyl transferase (GGT)(21) and/or Aspartate Aminotransferase (AST)(21) to platelet ratio index (APRI) score(21), and/or Alanine Aminotransferase (ALT) (21) which are the markers used to predict the severity of liver disease including the fatty liver. A blood test is required if you suspected to have developing nonfatty liver disease.
Conventionally, as of today, there is no effective treatment of NAFLD(22)(23). Weight loss for overweight and obese patients(22) has been recommended through our the industry accompanied by the change of lifestyles(22) such as moderate exercise and reduced intake of alcohol, depending on individuals.
Patients who are hepatitis virus B and C carriers are also recommended to be vaccinated(22).
Given the nature of the nonalcoholic fatty liver disease, the search for effective treatment for NAFLD from the natural sources used over thousands of years in traditional medicine for the treatment of liver disease has been intensified(23). Many secondary metabolites, whole foods, and herbal medicine have been found to be effective in vivo, vitro and small human trials(24). However, most of them were stopped due to a simple reason. Who will spend billions to prove the thing which has no commercial values? Secondary metabolites, whole foods, and herbal medicine cannot be patented.
B. Herbal medicines
Herbal medicines have been used as medicines over thousands of year in human history.
1. Herbal Anise
Herbal anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic (61).
On animal with NAFLD induced by choline-deficient diet for 90 days, 30 days treatment with hydroethanolic extract (AE) at 25, 50, 100, and 200 mg/kg/day and essential oil (AO) at 0.125, 0.25, and 0.5 mg/kg/day, reversed plasma levels of total cholesterol(62), low-density lipoprotein(62), and triacylglycerol(62) and decreased in high-density lipoprotein level(62) caused by choline-deficient diet in dose-dependent manner.
AE and AO also reduced the elevated levels of enzymes aspartate transaminase (AST)(62) and alanine transaminase (ALT)(62) which are considered as an indication of either liver injury or damage caused by the acute inflammation.
Additionally, anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress(62) indicated by elevation of plasma level of 8-isoprostane(62) which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).
2. Hawthorn Fruit
Hawthorn is shrubs and trees of the genus Crataegus, belonging to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia and North America(63) used in traditional medicine to treat heart disease and symptoms of heart diseases(63) such as irregular heartbeat(63), high blood pressure(63), chest pain(63), hardening of the arteries(63), circulatory disorders and respiratory illnesses(63).
Researchers at The First Affiliated Hospital of Wenzhou Medical College, in the concerns that nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition worldwide, and reaffirmation of the natural treatments of nonalcoholic fatty liver disease (NAFLD) in the traditional Chinese medicine (TCM), launched an investigation to find natural medicines for the treatment of NAFLD, suggested that hawthorn fruit was one the favorite herb used in TCM for the treatment of NAFLD compared to other herbs(64).
Furthermore, the search of the database of PubMed and China National Knowledge Infrastructure from January 1995 to June 2010 for RCTs by comparing either traditional Chinese medicine (TCM) formulations alone or in combination with placebo for the treatment of NAFLD, a formula containing hawthorn normalized alanine aminotransferase(65) and disappearance of radiological steatosis(65) in patients with NAFLD, without inducing any side effects(65).
3. Sida rhomboidea Roxb
Sida rhomboidea Roxb is a shrubby weed found growing throughout India belonging to the Malvaceae family, used in North-East India for the treatment of hypolipidemia and diabetes properties(66).
On a high-fat diet (HFD) induced insulin resistance in C57BL/6J mice, Sida rhomboidea ROXB. (S. rhomboidea ROXB., SR) compared to mice fed with rosiglitazone (ROS) lowered the plasma(67) and hepatic TC(67), TG(67) and FFA(67) in HFD+SR groups.
According to the efficient clearance of glucose in intraperitoneal glucose tolerance test (IPGTT), Sida rhomboidea ROXB also lowered the plasma insulin(67) and fasting insulin resistance(67) levels in HFD+SR groups.
Furthermore, in vivo, sida rhomboidea. Roxb leaf extract (SRLE) supplementation with SRLE significantly prevented HFD induced increment in body weight(68), plasma lipids(68) and leptin(68), visceral adiposity(68)and adipocyte hypertrophy(68) by modulation of related genes expression(68).
In vitro, Roxb leaf extract (SRLE) decreased triglyceride accumulation(68), leptin release(68) and glyceraldehyde-3-Phosphate dehydrogenase activity(68) along with higher glycerol release(68) without significant alteration of the viability of 3T3L1 pre-adipocytes(68).
4. Teucrium polium (Golden Germander)
Teucrium polium, known popularly as felty germander, is a sub-shrub and herb, belonging to the Lamiaceae family, native to the western Mediterranean, found abundantly in South-Western Asia, Europe, and North Africa. and used in traditional medicine for the treatment of abdominal pain, indigestion, common cold, and type 2 diabetes(69).
In nonalcoholic steatohepatitis induced in male N‐Mary rats by a methionine/choline‐deficient (MCD) diet, ethyl acetate (EtOAc) extract of Teucrium polium, inhibited inflammation(70) and ballooning degeneration by 80%(70) of the rats treated by MCD diet.
Furthermore, EtOAc extract also lowered the lipoprotein profiles(70) and levels of liver oxidative stress(70) markers such as alkaline phosphatase(70), aspartate aminotransferase(70), and alanine aminotransferase(70) by improving the liver superoxide dismutase(70), glutathione peroxidase(70), and glutathione reductase enzymes(70).
Moreover, in N-Mary rats induced NASH by methionine and choline-deficient (MCD) diet for 8 weeks, injection of ethyl acetate fraction of T. polium orally for 3 weeks, lowered the elevated levels of proteins(71) associated with inflammation and malondialdehyde (MDA)(71) in the liver.
The extract increased the levels of antioxidants enzymes activities such as superoxide dismutase (SOD)(71), glutathione peroxidase (GPx)(71) and hepatic glutathione (GSH)(71).
In other words, the ethyl acetate fraction of T. poium effectively protected the liver by reversing NASH(71), through its strong antioxidant(71) and anti-inflammatory properties(71).
5. Grape seed extract
Grape Seed Extract is the commercial extracts from whole grape seeds that contains many concentrations, including vitamin E, flavonoids, linoleic acid, oligomeric proanthocyanidins(OPCs), and used in traditional medicine as antioxidant, anti-inflammatory agents and to treat skin wounds with less scarring, allergies, macular degeneration, arthritis, enhance circulation of blood vessels, lower cholesterol(72)
In rats fed a high-fat diet to induce non-alcoholic fatty liver disease(NAFLD), resveratrol (RSV) administration reversed the abdominal obesity(73), NAFLD(73), and insulin resistance (IR)(73) by 10 weeks.
In vitro, RSV treatment inhibited the triacylglycerol (TG) accumulation(73) in HepG2 cells incubated with a high concentration of glucose(73), and insulin(73).
In other words, resveratrol (RSV) improved NAFLD(73) and IR(73) by suppressing the 2 lipogenesis genes(73) associated with the elevation of NAFLD(73) and IR expression (73).
Additionally, injection of resveratrol (RSV) also found to induced production of hepatic low-density lipoprotein(74) which has been found to process similarly activity as high-density lipoprotein which returns cholesterol to the liver.
6. Milk thistles
Milk Thistle is a flowering plant, in the genus Silybum Adans, belonging to the family Asteraceae, native to the Mediterranean, used in traditional medicine for the treatment of liver, kidney, and gall bladder problems(75).
According to the study lead by First Hospital of Jilin University in the review of eight RCTs involving 587 patients with NAFLD, Silymarin (SIL), an active extraction of milk thistle, significantly reduced liver oxidative stress(76) associated with the AST(76) and ALT levels(76).
In other words, SIL improved the liver parameters(76) by reducing transaminases levels(76) in NAFLD patients.
Furthermore, on hepatic steatosis and oxidative stress during the development of nonalcoholic fatty liver disease (NAFLD), administration of SMO decreased the histological injury of the liver(77) and the levels of hepatic triglyceride(77), cholesterol(77) and free fatty acid(77) in HFD-fed mice.
Moreover, SMO administration elevated the activities of superoxide dismutase (SOD)(77) and catalase (CAT)(77) and reduced the level of malondialdehyde (MDA)(77) and lowered the levels of proteins(77) involved in the production of pro-inflammatory cytokines(77) in the liver, thus preventing the onset of NAFLD.
7. Acanthopanax senticosus (Siberian Ginseng)
Acanthopanax senticosus or Siberian Ginseng is an oriental herb belonging to the Araliaceae family commonly distributed throughout the North Eastern parts of Asia, used in traditional Chinese medicine for the treatment of arthritis, hypertension, heart disease, gastric ulcers, and tumors(78).
On 10 obesity C57BL/6J mice fed either a normal diet (10 kcal fat%) or high-fat diet (60 kcal fat%) with or without oral administration of A. senticosus extract (ASE; 0.5 g/kg of body weight) for 12 weeks, ASE inhibited the significantly higher low-density lipoprotein (LDL)-cholesterol in serum(79) and higher triglyceride accumulation in liver(79), of mice high-fat diet without altering the levels of carnitine status(79).
Collectively, oral administration of ASE lowered the weight gain(79), serum LDL-cholesterol concentration(79), and liver triglycerides accumulation(79) in mice with obesity induced by high-fat diets.
In insulin-resistant ob/ob mice with fatty livers, 50% ethanol extract ofAcanthopanax senticosus stem bark (ASSB) reversed the hepatomegaly(80), by reducing the % liver weight/body weight ratio(80) in 8 weeks.
The ASSB ethanol extract also specifically lowered circulating glucose(80) and lipids(80) and enhanced insulin(80) action in the liver and triglyceride synthesis(80) in non-adipose tissues including liver and skeletal muscle(80).
Genes expression of glucose 6-phosphatase and lipogenic enzymes associated with the development of hepatic steatosis(80) also were reduced by the injection of ASSB ethanol extract.
8. Alisma Orientalis (Alismatis rhizome) or Ze Xie in traditional Chinese Medicine
Ze Xie is also known as Alisma, used in TCM as anti-pyretic, as anti-bacterial, hypoglycemic, hypotensive, antitumor, and anti-allergic medicine(81).
On rats fed with high‐fat diet for six weeks induced nonalcoholic fatty liver disease (NAFLD), followed by AOME for another six weeks, administration of AOME (150,300 and 600 mg kg−1) markedly decreased the serum and liver lipids(82), fasting serum glucose(82) and improved insulin resistance(82).
AOME lessened the lipid peroxidation(82) and activated antioxidant enzymes(82) through inhibiting the oxidative stress in the liver(82).
Furthermore, according to the tested assays, AOME also protected the liver against injury(82) by reducing the aminotransferase abnormalities(82) and hepatomegaly(82).
9. Cissus quadrangularis (Asthisamharaka)
Cissus quadrangularis is a perennial plant, belonging to the grape family, native to India, Srilanka, Malaysia, Thailand, and Africa used in the traditional medicine for the treatment of obesity, diabetes, and metabolic syndrome(83)
On oxidant-antioxidant balance and insulin resistance (IR) in rats fed high fat–high fructose diet (HFFD) and free-radical scavenging property in vitro, CQEt addition for 45 days restored insulin sensitivity (84), liver damage(84), and oxidative changes(84), on (HFFD) rats by and bring back the antioxidants and lipids towards normal(84).
Furthermore, CQEt protected the liver by improving the histopathology(84)of the liver.
In vivo, CQEtin also exerted liver protective effect(84) comparable with that of standard drug, metformin.
In vitro, CQEt exhibited radical scavenging ability(84) in a dose-dependent manner.
In other words, dietary supplementation of CQ extract (10%) for 45 days significantly improved insulin sensitivity(84), reduced liver damage(84), prevented oxidative changes(84).
10. Clerodendron glandulosum
Clerodendron glandulosum is comprised of small trees, shrub sand herbs belonging to the Verbenaceae family, native the tropical and sub-tropical regions of the world used in the traditional medicine for the treatment of hypertension, fever, diabetes, and abdominal pain(85).
On hyperlipidemic chronically rat fed by a high-fat diet (HL), administration of aqueous extract of Clerodendron glandulosum. Caleb (CG) (400 mg/kg/day) for 90 days, showed to reduce the levels of LDL-C (81.36%) (86)and VLDL-C (43%)(86) along with an increase in HDL-C (52.84%)(86).
On alteration in lipid and cholesterol metabolism in high-fat diet fed hyperlipidemic rats, compared to hypolipidemic drug Lovastatin (LVS), injection of ECG exerted a strong effect in experimental hyperlipidemia(86) by a significant alteration in plasma and tissue lipid profiles(86).
Further differentiation of the efficacy of ECG, researchers found that ECG reduced absorption(86), improved elimination(86) and augmented catabolism(86) of lipids and cholesterol.
11. Curcuma longa (Turmeric)
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia used in traditional medicine for the treatment of varies illness, including metabolic syndrome and inflammatory conditions(87).
On C57BL/6 mice fed an HFD for 16 weeks, daily oral administration (os) of the NDS inhibited steatosis (88), aortic lesions(88) or carotid artery thickening(88) induced by the HFD.
Furthermore, NDS inhibited dyslipidemia(88) compared to untreated animals.
In other words, NDS prevented the onset of NAFLD and atherogenesis(88) by modulating the expression of different genes(88) involved in NAFLD.
According to the double-blind randomized controlled clinical trial conducted on 46 patients with NAFLD (21males and 25 females) aged 20-60 years old and body mass index (BMI) between 24.9 and 40 kg/m2, turmeric group (n = 23) given six turmeric capsules daily for 12 weeks with each capsule contained 500 mg turmeric powder (6×500 mg) showed the decreased serum levels of glucose(89), insulin(89), HOMA-IR(89), and leptin(89) compared to the placebo group without affecting the weight, BMI and liver enzymes.
Collectively, turmeric supplementation inhibited NAFLD complications by improving glucose indexes(89) and serum leptin levels(89).
12. Ginkgo biloba (Maidenhair Tree)
Ginkgo biloba is the oldest living tree species, genus Ginkgo, belonging to the family Ginkgoaceae, native to China, from the temperate zone to subtropical zone and some parts of North America, used in traditional herbal medicine in treating impotence, memory loss, respiratory diseases, circulatory disorders, and deafness as well as preventing drunkenness, and bedwetting(90).
In vivo, on Male Wistar rats divided into 4 groups (the control group, GBE group, high-fat diet [HFD] group, and HFD + GBE group) researchers examined the effect of Ginkgo biloba extract (GBE) on nonalcoholic fatty liver disease (NAFLD).
According to the experimental results, GBE reduced the elevations of hepatic triglyceride contents(91) and the increased hepatic fatty acids(91) in rat livers caused by HFD.
Furthermore, GBE also enhanced the expression palmitoyltransferase I (CPT I) and total activity of the fatty acid β-oxidation rate-limiting enzyme, in the regulation of whole-body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease(91).
The effects of GBE was attributed to its chemical compounds and ingredients, quercetin, kaempferol, and isorhamnetin which work synergistically to decrease the cellular triglyceride content(91) and promote the expression and total activity of CPT1A(91) in converting fat to energy.
Based on the finding, researchers wrote, "The triglyceride-lowering effect of GBE on the HFD rat liver is closely associated with the increased expression and activity of CPT1A, and the flavonoid ingredients are the major contributors of GBE".
13. Linum usitatissimum (Linseed/Flaxseed)
Flaxseed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed. Flax is an erect annual plant, it can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad, used in traditional medicine for the treatment of constipation(92).
A double-blinded, randomized, and placebo-controlled study in moderately hypercholesterolemic men suggested that oral administration of SDG (20 or 100 mg) decreases the level of blood cholesterol(93) and liver disease risk factors(93) induced by hypercholesterolemia in humans.
In a study of 30 men with total cholesterol levels of 4.65 to 6.21 mmol/L (180-240 mg/dL), SDG exhibited a significant reduction in the ratio of low-density lipoprotein/high-density lipoprotein cholesterol(93) compared to baseline at week 12.
Furthermore, injection of SDG also showed a significant percentage decrease in the levels of glutamic pyruvic transaminase(93) and γ-glutamyl transpeptidase(93) associated with liver injury markers related to the levels at the baseline.
In other words, daily administration of 100 mg SDG may be effective in reducing the levels of blood cholesterol(93) and hepatic diseases risk(93) in moderately hypercholesterolemic men.
In the testing of 7-d diets including a low-fiber control diet (Control), a diet with flaxseed fiber drink (3/day) (Flax drink), and a diet with flaxseed fiber bread (3/day) (Flax bread), researchers found that compared to control, Flax drink lowered fasting total-cholesterol and LDL-cholesterol by 12 and 15%(94), respectively.
Fecal fat and energy excretion increased by 50 and 23% with Flax drink consumption compared to control(94).
In other words, Flax drink decreased plasma total and LDL-cholesterol(94) and increased fat excretion(94).
14. Nelumbo nucifera (Lotus)
Nelumbo nucifera (Lotus) is a perennial plant belonging to the Nymphaeaceae family produced individual leaves and flowers directly from the root system and used in traditional medicine for the treatment of respiratory, hepatic, digestive, and reproductive diseases(95).
On 3T3-L1 preadipocytes and high-fat diet (HFD)-induced obese SD rats, injection of N. nucifera leaves extract, N. nucifera alkaloid (NNA) decreased cell population growth of 3T3-L1(a cell line derived from (mouse) 3T3 cells used in biological research on adipose tissue) preadipocytes(96) and increased the apoptotic cells(96) in a time- and dose-dependent manner and reduced the body weight(96), the lee's index(96), adipose tissue weight(96), and plasma lipid levels((96) in HFD-induced obese rats.
In vivo, C57BL/6 mice induced obesity by a high-fat diet (HFD), oral administration of NLFE reduced the body weight(97), body lipid accumulation(97), and activities of fatty acid synthase (FAS)(97), glutamic oxaloacetic transaminase(97), and glutamic pyruvic transaminase(97) associated with the risk of NAFLD.
Additionally, NLFE efficacy in the attenuation of body lipid accumulation(97) and prevention of obesity(97) was associated with the inhibition of lipid-regulated enzymes involved in synthesizing lipids right in the cell(97).
D. Summary
Taken altogether, phytochemicals, herbal medicines, healthy foods found in the research paper may be considered remedies for the prevention and treatment of non-alcoholic fatty liver disease, pending to large sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
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(3) The Global Pattern of Urbanization and Economic Growth: Evidence from the Last Three Decades by Mingxing Chen, Hua Zhang, 2 Weidong Liu, 1 and Wenzhong Zhang. (PMC)
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(6) Epidemiology of non-alcoholic fatty liver disease in China by Fan JG1, Farrell GC. (PubMed)
(7) Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in the burden of disease by Chris Estes,
1 Homie Razavi, 1 Rohit Loomba, 2 Zobair Younossi, 3 and Arun J. Sanyal. (PMC)
(8) Symptoms & Causes of NAFLD & NASH by NIH
(9) Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy. by Nishizawa H1, Iguchi G, Murawaki A, Fukuoka H, Hayashi Y, Kaji H, Yamamoto M, Suda K, Takahashi M, Seo Y, Yano Y, Kitazawa R, Kitazawa S, Koga M, Okimura Y, Chihara K, Takahashi Y. (PubMed)
(10) Non-alcoholic fatty liver disease and thyroid dysfunction: A systematic review by Ahad Eshraghian and Alireza Hamidian Jahromi. (PMC)
(11) Obstructive sleep apnea syndrome and fatty liver: Association or causal link? by Mohamed H Ahmed and Christopher D Byrne, (PMC)
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(13) Dietary fat stimulates the development of NAFLD more potently than dietary fructose in Sprague-Dawley rats by Jensen VS1,2, Hvid H2, Damgaard J2, Nygaard H2, Ingvorsen C3, Wulff EM4, Lykkesfeldt J1, Fledelius C. (PubMed)
(14) Non-Alcoholic Fatty Liver Disease by NICK G. (The American Liver Foundation)
(15) Racial and Ethnic Disparities in Nonalcoholic Fatty Liver Disease Prevalence, Severity, and Outcomes in the United States: A Systematic Review and Meta-analysis by Rich NE1, Oji S1, Mufti AR1, Browning JD1, Parikh ND2, Odewole M1, Mayo H3, Singal AG. (PubMed)
(16) Emerging Trends Conference: EMERGING TRENDS IN NON-ALCOHOLIC FATTY LIVER DISEASE by AASLD
(17) Hepatic Encephalopathy by the Canadian Liver Foundation
(18) LIVER DISEASE AND ASCITES by Sequana Medical
(19) Nonalcoholic fatty liver disease manifesting esophageal variceal bleeding by Tang CP1, Huang YS, Tsay SH, Chang FY, Lee SD. (PubMed)
(20) Non-alcoholic fatty liver disease by Genetic Home Reference. (NIH)
(21) Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis by J K Dowman,*† J W Tomlinson,‡ and P N Newsome. (PMC)
(22) Current treatment options for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis by Melanie D Beaton, MD FRCPC. (PMC)
(23) Herbal medicines and nonalcoholic fatty liver disease by Hong Yao, Yu-Jie Qiao, Ya-Li Zhao, Xu-Feng Tao, Li-Na Xu, Lian-Hong Yin, Yan Qi, and Jin-Yong Peng. (PMC)
(24) An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes by Ajda Ota and Nataša P. Ulrich. (PubMed)
(61) Popular #Herbs - Anise Kyle J. Norton
(62) Pimpinella anisum L. fruit: Chemical composition and effect on a rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
(63) Popular Herbs - Hawthorn (Crataegus)
(64) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH. (PubMed)
(65) The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis by Lu FB1, Hu ED1, Xu LM1, Chen L1, Wu JL1, Li H1, Chen DZ2, Chen YP. (PubMed)
(66) Sida rhomboidea. Roxb Leaf Extract Down-Regulates Expression of PPARγ2 and Leptin Genes in High Fat Diet-Fed C57BL/6J Mice and Retards in Vitro 3T3L1 Pre-Adipocyte Differentiation by Menaka C. Thounaojam,1 Ravirajsinh N. Jadeja,1 Umed V. Ramani,2 Ranjitsinh V. Devkar,1,*and A. V. Ramachandran. (PMC)
(67) Prevention of High Fat Diet-Induced Insulin Resistance in C57BL/6J Mice by Sida rhomboidea ROXB. Extract by Menaka Chanu Thounaojam, Ravirajsinh Navalsinh Jadeja, Ansarullah, Ranjitsinh Vijaysinh Devkar, A. V. Ramachandran. (Journal of Health Science)
(68) Sida rhomboidea. Roxb Leaf Extract Down-Regulates Expression of PPARγ2 and Leptin Genes in High Fat Diet-Fed C57BL/6J Mice and Retards inVitro 3T3L1 Pre-Adipocyte Differentiation
Menaka C. Thounaojam 1, Ravirajsinh N. Jadeja 1, Umed V. Ramani 2, Ranjitsinh V. Devkar 1,* and. V. Ramachandran. ( International Journal of Molecular Science)
(69) Phytochemistry and medicinal properties of Teucrium polium L. (Lamiaceae) by Bahramikia S1, Yazdanparast R. (PubMed)
(70) Teucrium polium in the prevention of steatohepatitis in rats by Rahim Amini, Narges Nosrati, Razieh Yazdanparast, Mahsa Molaei. ( Liver International)
(71) Teucrium polium reversed the MCD diet-induced liver injury in rats by Rahim Amini, Razieh Yazdanparast and Safiyeh Aghazadeh. (Sage Journal)
(72) Popular Herbs - Grapefruit Seed Extract by Kyle J. Norton
(73) Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase by Shang J1, Chen LL, Xiao FX, Sun H, Ding HC, Xiao H. (PubMed)
(74) SIRT1 as a potential therapeutic target for the treatment of nonalcoholic fatty liver disease by Colak Y1, Ozturk O, Senates E, Tuncer I, Yorulmaz E, Adali G, Doganay L, Enc FY. (PubMed)
(75) Popular #Herbs - Milk Thistle by Kyle J. Norton
(76) The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease: A meta-analysis (PRISMA) of randomized control trials by Zhong S1, Fan Y, Yan Q, Fan X, Wu B, Han Y, Zhang Y, Chen Y, Zhang H, Niu J. (PubMed)
(77) Silybum marianum oil attenuates hepatic steatosis and oxidative stress in high fat diet-fed mice by Zhu SY1, Jiang N2, Yang J3, Tu J4, Zhou Y3, Xiao X3, Dong Y. (PubMed)
(78) Popular #Herbs - #Ginseng, Asian (Panax ginseng) and Ginseng, North America by Kyle J. Norton
(79) Acanthopanax senticosus Extract Prepared from Cultured Cells Decreases Adiposity and Obesity Indices in C57BL/6J Mice Fed a High Fat Diet by Youn-Soo Cha, Soon-Jae Rhee, and Young-Ran Heo. (Journal of Medicinal Food)
(80) Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice by Sang, Hyun Park, Sang Gil Lee, Sung Keel Kang, and Sung Hyun Chung. (Springer Link)
(81) Chinese Herbs – Ze Xie by Kyle J. Norton
(82) Protective effects of the Alisma Orientalis extract on the experimental nonalcoholic fatty liver disease byXuezhi Hong, Huiqing Tang, Limao Wu, and Lianda Li. (Wiley Online Library)
(83) Cissus quadrangularis by Wikipedia
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(85) Cissus quadrangularis - Wikipedia
(86) Clerodendron glandulosum Coleb., Verbenaceae, ameliorates high fat diet-induced alteration in lipid and cholesterol metabolism in rats by Jadeja RN; Thounaojam MC; Ansarullah; Devkar RV*; Ramachandran AV. (Scielo)
(87) Popular #Herbs - Turmeric (Curcuma longa) by Kyle J. Norton
(88) NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet by Amato A1, Caldara GF2, Nuzzo D3, Baldassano S4, Picone P5, Rizzo M6, Mulè F7, Di Carlo M. (PubMed)
(89) Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases by Navekar R1, Rafraf M1, Ghaffari A1, Asghari-Jafarabadi M2, Khoshbaten M. (PubMed)
(90) Popular Herbs - Ginkgo biloba by Kyle J. Norton
(91) Inhibitory effect of Ginkgo biloba extract on fatty liver: Regulation of carnitine palmitoyltransferase 1a and fatty acid metabolism by Shi Dong Wang, Zuoquan Xie, Jia Chen, and Ke Wang. (Research Gate)
(92) Superfoods - Flaxseed oil by Kyle J. Norton
(93) Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men by Fukumitsu S1, Aida K, Shimizu H, Toyoda K. (PubMed)
(94) Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but the magnitude of the effect depends on food type by Kristensen M1, Jensen MG, Aarestrup J, Petersen KE, Søndergaard L, Mikkelsen MS, Astrup A. (PubMed)
(95) A comprehensive review on Nymphaea stellata: A traditionally used bitter by M. K. Mohan Maruga Raja, Neeraj Kumar Sethiya, and S. H. Mishra. (PMC)
(96) Nelumbo nucifera alkaloid inhibits 3T3-L1 preadipocyte differentiation and improves high-fat-diet-induced obesity and body fat accumulation in rats by Xie Bin, Wan Jin, Wang Wenqing, and Shi Chunyang. (Research Gate)
(97) Improvement in High-Fat Diet-Induced Obesity and Body Fat Accumulation by a Nelumbo nucifera Leaf Flavonoid-Rich Extract in Mice by Cheng-Hsun Wu, Mon-Yuan Yang, Kuei-Chuan Chan, and Pei-Jun Chung. (Research Gate)
Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer.
According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease of the Western world(2). However, due to the economic prosperity of Southeast Asian(3), the disease also was found in a large number of population in the cities, causing concerns of many scientists in the region(4)(6).
According to the joint assessment of the prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the US, led by the Stanford University School of Medicine, "The prevalence of NAFLD in the United States (U.S.) has risen from 18% in 1988–1991 to 31% in 2011–2012. Estimates of NAFLD prevalence for adults in Western countries is 20–30%, with much higher prevalence in adults with obesity (80–90%), diabetes (30–50%), and hyperlipidemia (90%)"(5).
Among the more affluent regions of China, the prevalence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 15%(6). The number may decrease substantially if the poor rural populations where obesity is non-existence are also taking into account(7).
The exact causes of NAFLD aren't well understood. Some researchers suggested that certain risk factors such as long-term use of certain medications(8), genetic preposition(8), insulin resistance(8), high cholesterol(8) and triglycerides(8) in the blood, polycystic ovary syndrome(8), metabolic syndrome(8), obesity(8), and type 2 diabetes(8) are associated with the onset of the disease.
Recent studies also found that people with obstructive sleep apnea(11), underactive thyroid (hypothyroidism(10) and underactive pituitary gland (hypopituitarism) (9) also at an increased risk of the NALFD.
Some researchers suggested that unhealthy diet such as high-fat diet may also have a strong implication on NAFLD(12)(13).
Dr. Jensen VS, the lead scientist in the study high-fat diet-induced non-alcoholic fatty liver disease, wrote, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol has been linked to the development of non-alcoholic fatty liver disease (NAFLD)"(13).
And, " Only HFr-fed rats developed dyslipidemia as characterized by higher levels of plasma triglycerides compared to all other groups (p < 0.0001). Hepatic dysfunction and inflammation was confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control"(13).
According to the statistics, in the US, over 100 million people have non-alcoholic fatty liver disease and the condition is more double over the past 20 years(14). The disease also is the most prevalent liver disease in children(14).
The prevalence rate of NAFLD is varied among different ethnic groups in the US. Dr. Rich NE, the lead scientist in the investigation of the ethnicity and NAFLD, wrote, "NAFLD prevalence was highest in Hispanics, intermediate in Whites, and lowest in Blacks, although differences between groups were smaller in high-risk cohorts (range 47.6%-55.5%) than population-based cohorts (range, 13.0%-22.9%)(15)".
And, "Among patients with NAFLD, the risk of NASH was higher in Hispanics (relative risk, 1.09; 95% CI, 0.98-1.21) and lower in Blacks (relative risk, 0.72; 95% CI, 0.60-0.87) than Whites"(15).
The progression of NAFLD and NASH led to cirrhosis, the late stage of liver scarring are well defined, as the liver tries to heal itself by halting inflammation(16), leading to symptoms of ascites(16)(18), swell esophageal varices(16)(19), hepatic encephalopathy(16)(17) and complications of liver cancer(16)(17) and liver failure(16)(17).
Most people at the early stage NAFLD are asymptomatic, however, as the disease progression into the later stage, most patients experience symptoms of right upper abdominal discomfort(20), fatigue(20), and/or malaise(20), and jaundice(20) with yellowing of the skin and eyes(20).
Most patients with NAFLD have elevated levels of liver enzymes gamma-glutamyl transferase (GGT)(21) and/or Aspartate Aminotransferase (AST)(21) to platelet ratio index (APRI) score(21), and/or Alanine Aminotransferase (ALT) (21) which are the markers used to predict the severity of liver disease including the fatty liver. A blood test is required if you suspected to have developing nonfatty liver disease.
Conventionally, as of today, there is no effective treatment of NAFLD(22)(23). Weight loss for overweight and obese patients(22) has been recommended through our the industry accompanied by the change of lifestyles(22) such as moderate exercise and reduced intake of alcohol, depending on individuals.
Patients who are hepatitis virus B and C carriers are also recommended to be vaccinated(22).
Given the nature of the nonalcoholic fatty liver disease, the search for effective treatment for NAFLD from the natural sources used over thousands of years in traditional medicine for the treatment of liver disease has been intensified(23). Many secondary metabolites, whole foods, and herbal medicine have been found to be effective in vivo, vitro and small human trials(24). However, most of them were stopped due to a simple reason. Who will spend billions to prove the thing which has no commercial values? Secondary metabolites, whole foods, and herbal medicine cannot be patented.
B. Herbal medicines
Herbal medicines have been used as medicines over thousands of year in human history.
1. Herbal Anise
Herbal anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic (61).
On animal with NAFLD induced by choline-deficient diet for 90 days, 30 days treatment with hydroethanolic extract (AE) at 25, 50, 100, and 200 mg/kg/day and essential oil (AO) at 0.125, 0.25, and 0.5 mg/kg/day, reversed plasma levels of total cholesterol(62), low-density lipoprotein(62), and triacylglycerol(62) and decreased in high-density lipoprotein level(62) caused by choline-deficient diet in dose-dependent manner.
AE and AO also reduced the elevated levels of enzymes aspartate transaminase (AST)(62) and alanine transaminase (ALT)(62) which are considered as an indication of either liver injury or damage caused by the acute inflammation.
Additionally, anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress(62) indicated by elevation of plasma level of 8-isoprostane(62) which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).
2. Hawthorn Fruit
Hawthorn is shrubs and trees of the genus Crataegus, belonging to the family Rosaceae, native to temperate regions of the Northern Hemisphere in Europe, Asia and North America(63) used in traditional medicine to treat heart disease and symptoms of heart diseases(63) such as irregular heartbeat(63), high blood pressure(63), chest pain(63), hardening of the arteries(63), circulatory disorders and respiratory illnesses(63).
Researchers at The First Affiliated Hospital of Wenzhou Medical College, in the concerns that nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition worldwide, and reaffirmation of the natural treatments of nonalcoholic fatty liver disease (NAFLD) in the traditional Chinese medicine (TCM), launched an investigation to find natural medicines for the treatment of NAFLD, suggested that hawthorn fruit was one the favorite herb used in TCM for the treatment of NAFLD compared to other herbs(64).
Furthermore, the search of the database of PubMed and China National Knowledge Infrastructure from January 1995 to June 2010 for RCTs by comparing either traditional Chinese medicine (TCM) formulations alone or in combination with placebo for the treatment of NAFLD, a formula containing hawthorn normalized alanine aminotransferase(65) and disappearance of radiological steatosis(65) in patients with NAFLD, without inducing any side effects(65).
3. Sida rhomboidea Roxb
Sida rhomboidea Roxb is a shrubby weed found growing throughout India belonging to the Malvaceae family, used in North-East India for the treatment of hypolipidemia and diabetes properties(66).
On a high-fat diet (HFD) induced insulin resistance in C57BL/6J mice, Sida rhomboidea ROXB. (S. rhomboidea ROXB., SR) compared to mice fed with rosiglitazone (ROS) lowered the plasma(67) and hepatic TC(67), TG(67) and FFA(67) in HFD+SR groups.
According to the efficient clearance of glucose in intraperitoneal glucose tolerance test (IPGTT), Sida rhomboidea ROXB also lowered the plasma insulin(67) and fasting insulin resistance(67) levels in HFD+SR groups.
Furthermore, in vivo, sida rhomboidea. Roxb leaf extract (SRLE) supplementation with SRLE significantly prevented HFD induced increment in body weight(68), plasma lipids(68) and leptin(68), visceral adiposity(68)and adipocyte hypertrophy(68) by modulation of related genes expression(68).
In vitro, Roxb leaf extract (SRLE) decreased triglyceride accumulation(68), leptin release(68) and glyceraldehyde-3-Phosphate dehydrogenase activity(68) along with higher glycerol release(68) without significant alteration of the viability of 3T3L1 pre-adipocytes(68).
4. Teucrium polium (Golden Germander)
Teucrium polium, known popularly as felty germander, is a sub-shrub and herb, belonging to the Lamiaceae family, native to the western Mediterranean, found abundantly in South-Western Asia, Europe, and North Africa. and used in traditional medicine for the treatment of abdominal pain, indigestion, common cold, and type 2 diabetes(69).
In nonalcoholic steatohepatitis induced in male N‐Mary rats by a methionine/choline‐deficient (MCD) diet, ethyl acetate (EtOAc) extract of Teucrium polium, inhibited inflammation(70) and ballooning degeneration by 80%(70) of the rats treated by MCD diet.
Furthermore, EtOAc extract also lowered the lipoprotein profiles(70) and levels of liver oxidative stress(70) markers such as alkaline phosphatase(70), aspartate aminotransferase(70), and alanine aminotransferase(70) by improving the liver superoxide dismutase(70), glutathione peroxidase(70), and glutathione reductase enzymes(70).
Moreover, in N-Mary rats induced NASH by methionine and choline-deficient (MCD) diet for 8 weeks, injection of ethyl acetate fraction of T. polium orally for 3 weeks, lowered the elevated levels of proteins(71) associated with inflammation and malondialdehyde (MDA)(71) in the liver.
The extract increased the levels of antioxidants enzymes activities such as superoxide dismutase (SOD)(71), glutathione peroxidase (GPx)(71) and hepatic glutathione (GSH)(71).
In other words, the ethyl acetate fraction of T. poium effectively protected the liver by reversing NASH(71), through its strong antioxidant(71) and anti-inflammatory properties(71).
5. Grape seed extract
Grape Seed Extract is the commercial extracts from whole grape seeds that contains many concentrations, including vitamin E, flavonoids, linoleic acid, oligomeric proanthocyanidins(OPCs), and used in traditional medicine as antioxidant, anti-inflammatory agents and to treat skin wounds with less scarring, allergies, macular degeneration, arthritis, enhance circulation of blood vessels, lower cholesterol(72)
In rats fed a high-fat diet to induce non-alcoholic fatty liver disease(NAFLD), resveratrol (RSV) administration reversed the abdominal obesity(73), NAFLD(73), and insulin resistance (IR)(73) by 10 weeks.
In vitro, RSV treatment inhibited the triacylglycerol (TG) accumulation(73) in HepG2 cells incubated with a high concentration of glucose(73), and insulin(73).
In other words, resveratrol (RSV) improved NAFLD(73) and IR(73) by suppressing the 2 lipogenesis genes(73) associated with the elevation of NAFLD(73) and IR expression (73).
Additionally, injection of resveratrol (RSV) also found to induced production of hepatic low-density lipoprotein(74) which has been found to process similarly activity as high-density lipoprotein which returns cholesterol to the liver.
6. Milk thistles
Milk Thistle is a flowering plant, in the genus Silybum Adans, belonging to the family Asteraceae, native to the Mediterranean, used in traditional medicine for the treatment of liver, kidney, and gall bladder problems(75).
According to the study lead by First Hospital of Jilin University in the review of eight RCTs involving 587 patients with NAFLD, Silymarin (SIL), an active extraction of milk thistle, significantly reduced liver oxidative stress(76) associated with the AST(76) and ALT levels(76).
In other words, SIL improved the liver parameters(76) by reducing transaminases levels(76) in NAFLD patients.
Furthermore, on hepatic steatosis and oxidative stress during the development of nonalcoholic fatty liver disease (NAFLD), administration of SMO decreased the histological injury of the liver(77) and the levels of hepatic triglyceride(77), cholesterol(77) and free fatty acid(77) in HFD-fed mice.
Moreover, SMO administration elevated the activities of superoxide dismutase (SOD)(77) and catalase (CAT)(77) and reduced the level of malondialdehyde (MDA)(77) and lowered the levels of proteins(77) involved in the production of pro-inflammatory cytokines(77) in the liver, thus preventing the onset of NAFLD.
7. Acanthopanax senticosus (Siberian Ginseng)
Acanthopanax senticosus or Siberian Ginseng is an oriental herb belonging to the Araliaceae family commonly distributed throughout the North Eastern parts of Asia, used in traditional Chinese medicine for the treatment of arthritis, hypertension, heart disease, gastric ulcers, and tumors(78).
On 10 obesity C57BL/6J mice fed either a normal diet (10 kcal fat%) or high-fat diet (60 kcal fat%) with or without oral administration of A. senticosus extract (ASE; 0.5 g/kg of body weight) for 12 weeks, ASE inhibited the significantly higher low-density lipoprotein (LDL)-cholesterol in serum(79) and higher triglyceride accumulation in liver(79), of mice high-fat diet without altering the levels of carnitine status(79).
Collectively, oral administration of ASE lowered the weight gain(79), serum LDL-cholesterol concentration(79), and liver triglycerides accumulation(79) in mice with obesity induced by high-fat diets.
In insulin-resistant ob/ob mice with fatty livers, 50% ethanol extract ofAcanthopanax senticosus stem bark (ASSB) reversed the hepatomegaly(80), by reducing the % liver weight/body weight ratio(80) in 8 weeks.
The ASSB ethanol extract also specifically lowered circulating glucose(80) and lipids(80) and enhanced insulin(80) action in the liver and triglyceride synthesis(80) in non-adipose tissues including liver and skeletal muscle(80).
Genes expression of glucose 6-phosphatase and lipogenic enzymes associated with the development of hepatic steatosis(80) also were reduced by the injection of ASSB ethanol extract.
8. Alisma Orientalis (Alismatis rhizome) or Ze Xie in traditional Chinese Medicine
Ze Xie is also known as Alisma, used in TCM as anti-pyretic, as anti-bacterial, hypoglycemic, hypotensive, antitumor, and anti-allergic medicine(81).
On rats fed with high‐fat diet for six weeks induced nonalcoholic fatty liver disease (NAFLD), followed by AOME for another six weeks, administration of AOME (150,300 and 600 mg kg−1) markedly decreased the serum and liver lipids(82), fasting serum glucose(82) and improved insulin resistance(82).
AOME lessened the lipid peroxidation(82) and activated antioxidant enzymes(82) through inhibiting the oxidative stress in the liver(82).
Furthermore, according to the tested assays, AOME also protected the liver against injury(82) by reducing the aminotransferase abnormalities(82) and hepatomegaly(82).
9. Cissus quadrangularis (Asthisamharaka)
Cissus quadrangularis is a perennial plant, belonging to the grape family, native to India, Srilanka, Malaysia, Thailand, and Africa used in the traditional medicine for the treatment of obesity, diabetes, and metabolic syndrome(83)
On oxidant-antioxidant balance and insulin resistance (IR) in rats fed high fat–high fructose diet (HFFD) and free-radical scavenging property in vitro, CQEt addition for 45 days restored insulin sensitivity (84), liver damage(84), and oxidative changes(84), on (HFFD) rats by and bring back the antioxidants and lipids towards normal(84).
Furthermore, CQEt protected the liver by improving the histopathology(84)of the liver.
In vivo, CQEtin also exerted liver protective effect(84) comparable with that of standard drug, metformin.
In vitro, CQEt exhibited radical scavenging ability(84) in a dose-dependent manner.
In other words, dietary supplementation of CQ extract (10%) for 45 days significantly improved insulin sensitivity(84), reduced liver damage(84), prevented oxidative changes(84).
10. Clerodendron glandulosum
Clerodendron glandulosum is comprised of small trees, shrub sand herbs belonging to the Verbenaceae family, native the tropical and sub-tropical regions of the world used in the traditional medicine for the treatment of hypertension, fever, diabetes, and abdominal pain(85).
On hyperlipidemic chronically rat fed by a high-fat diet (HL), administration of aqueous extract of Clerodendron glandulosum. Caleb (CG) (400 mg/kg/day) for 90 days, showed to reduce the levels of LDL-C (81.36%) (86)and VLDL-C (43%)(86) along with an increase in HDL-C (52.84%)(86).
On alteration in lipid and cholesterol metabolism in high-fat diet fed hyperlipidemic rats, compared to hypolipidemic drug Lovastatin (LVS), injection of ECG exerted a strong effect in experimental hyperlipidemia(86) by a significant alteration in plasma and tissue lipid profiles(86).
Further differentiation of the efficacy of ECG, researchers found that ECG reduced absorption(86), improved elimination(86) and augmented catabolism(86) of lipids and cholesterol.
11. Curcuma longa (Turmeric)
Turmeric, principal curcuminoid of the popular Indian spice, a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical South Asia used in traditional medicine for the treatment of varies illness, including metabolic syndrome and inflammatory conditions(87).
On C57BL/6 mice fed an HFD for 16 weeks, daily oral administration (os) of the NDS inhibited steatosis (88), aortic lesions(88) or carotid artery thickening(88) induced by the HFD.
Furthermore, NDS inhibited dyslipidemia(88) compared to untreated animals.
In other words, NDS prevented the onset of NAFLD and atherogenesis(88) by modulating the expression of different genes(88) involved in NAFLD.
According to the double-blind randomized controlled clinical trial conducted on 46 patients with NAFLD (21males and 25 females) aged 20-60 years old and body mass index (BMI) between 24.9 and 40 kg/m2, turmeric group (n = 23) given six turmeric capsules daily for 12 weeks with each capsule contained 500 mg turmeric powder (6×500 mg) showed the decreased serum levels of glucose(89), insulin(89), HOMA-IR(89), and leptin(89) compared to the placebo group without affecting the weight, BMI and liver enzymes.
Collectively, turmeric supplementation inhibited NAFLD complications by improving glucose indexes(89) and serum leptin levels(89).
12. Ginkgo biloba (Maidenhair Tree)
Ginkgo biloba is the oldest living tree species, genus Ginkgo, belonging to the family Ginkgoaceae, native to China, from the temperate zone to subtropical zone and some parts of North America, used in traditional herbal medicine in treating impotence, memory loss, respiratory diseases, circulatory disorders, and deafness as well as preventing drunkenness, and bedwetting(90).
In vivo, on Male Wistar rats divided into 4 groups (the control group, GBE group, high-fat diet [HFD] group, and HFD + GBE group) researchers examined the effect of Ginkgo biloba extract (GBE) on nonalcoholic fatty liver disease (NAFLD).
According to the experimental results, GBE reduced the elevations of hepatic triglyceride contents(91) and the increased hepatic fatty acids(91) in rat livers caused by HFD.
Furthermore, GBE also enhanced the expression palmitoyltransferase I (CPT I) and total activity of the fatty acid β-oxidation rate-limiting enzyme, in the regulation of whole-body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease(91).
The effects of GBE was attributed to its chemical compounds and ingredients, quercetin, kaempferol, and isorhamnetin which work synergistically to decrease the cellular triglyceride content(91) and promote the expression and total activity of CPT1A(91) in converting fat to energy.
Based on the finding, researchers wrote, "The triglyceride-lowering effect of GBE on the HFD rat liver is closely associated with the increased expression and activity of CPT1A, and the flavonoid ingredients are the major contributors of GBE".
13. Linum usitatissimum (Linseed/Flaxseed)
Flaxseed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed. Flax is an erect annual plant, it can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad, used in traditional medicine for the treatment of constipation(92).
A double-blinded, randomized, and placebo-controlled study in moderately hypercholesterolemic men suggested that oral administration of SDG (20 or 100 mg) decreases the level of blood cholesterol(93) and liver disease risk factors(93) induced by hypercholesterolemia in humans.
In a study of 30 men with total cholesterol levels of 4.65 to 6.21 mmol/L (180-240 mg/dL), SDG exhibited a significant reduction in the ratio of low-density lipoprotein/high-density lipoprotein cholesterol(93) compared to baseline at week 12.
Furthermore, injection of SDG also showed a significant percentage decrease in the levels of glutamic pyruvic transaminase(93) and γ-glutamyl transpeptidase(93) associated with liver injury markers related to the levels at the baseline.
In other words, daily administration of 100 mg SDG may be effective in reducing the levels of blood cholesterol(93) and hepatic diseases risk(93) in moderately hypercholesterolemic men.
In the testing of 7-d diets including a low-fiber control diet (Control), a diet with flaxseed fiber drink (3/day) (Flax drink), and a diet with flaxseed fiber bread (3/day) (Flax bread), researchers found that compared to control, Flax drink lowered fasting total-cholesterol and LDL-cholesterol by 12 and 15%(94), respectively.
Fecal fat and energy excretion increased by 50 and 23% with Flax drink consumption compared to control(94).
In other words, Flax drink decreased plasma total and LDL-cholesterol(94) and increased fat excretion(94).
14. Nelumbo nucifera (Lotus)
Nelumbo nucifera (Lotus) is a perennial plant belonging to the Nymphaeaceae family produced individual leaves and flowers directly from the root system and used in traditional medicine for the treatment of respiratory, hepatic, digestive, and reproductive diseases(95).
On 3T3-L1 preadipocytes and high-fat diet (HFD)-induced obese SD rats, injection of N. nucifera leaves extract, N. nucifera alkaloid (NNA) decreased cell population growth of 3T3-L1(a cell line derived from (mouse) 3T3 cells used in biological research on adipose tissue) preadipocytes(96) and increased the apoptotic cells(96) in a time- and dose-dependent manner and reduced the body weight(96), the lee's index(96), adipose tissue weight(96), and plasma lipid levels((96) in HFD-induced obese rats.
In vivo, C57BL/6 mice induced obesity by a high-fat diet (HFD), oral administration of NLFE reduced the body weight(97), body lipid accumulation(97), and activities of fatty acid synthase (FAS)(97), glutamic oxaloacetic transaminase(97), and glutamic pyruvic transaminase(97) associated with the risk of NAFLD.
Additionally, NLFE efficacy in the attenuation of body lipid accumulation(97) and prevention of obesity(97) was associated with the inhibition of lipid-regulated enzymes involved in synthesizing lipids right in the cell(97).
D. Summary
Taken altogether, phytochemicals, herbal medicines, healthy foods found in the research paper may be considered remedies for the prevention and treatment of non-alcoholic fatty liver disease, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
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(3) The Global Pattern of Urbanization and Economic Growth: Evidence from the Last Three Decades by Mingxing Chen, Hua Zhang, 2 Weidong Liu, 1 and Wenzhong Zhang. (PMC)
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(5) Prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the United States by Michael H. Le,1 Pardha Devaki,2 Nghiem B. Ha,3,4 Dae Won Jun,5 Helen S. Te,6Ramsey C. Cheung,4,7 and Mindie H. Nguyen. (PMC)
(6) Epidemiology of non-alcoholic fatty liver disease in China by Fan JG1, Farrell GC. (PubMed)
(7) Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in the burden of disease by Chris Estes,
1 Homie Razavi, 1 Rohit Loomba, 2 Zobair Younossi, 3 and Arun J. Sanyal. (PMC)(8) Symptoms & Causes of NAFLD & NASH by NIH
(9) Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy. by Nishizawa H1, Iguchi G, Murawaki A, Fukuoka H, Hayashi Y, Kaji H, Yamamoto M, Suda K, Takahashi M, Seo Y, Yano Y, Kitazawa R, Kitazawa S, Koga M, Okimura Y, Chihara K, Takahashi Y. (PubMed)
(10) Non-alcoholic fatty liver disease and thyroid dysfunction: A systematic review by Ahad Eshraghian and Alireza Hamidian Jahromi. (PMC)
(11) Obstructive sleep apnea syndrome and fatty liver: Association or causal link? by Mohamed H Ahmed and Christopher D Byrne, (PMC)
(12) Diets and nonalcoholic fatty liver disease: The good and the bad by Mohamed Asrih, François R. Jornayvaz. (El Sevier)
(13) Dietary fat stimulates the development of NAFLD more potently than dietary fructose in Sprague-Dawley rats by Jensen VS1,2, Hvid H2, Damgaard J2, Nygaard H2, Ingvorsen C3, Wulff EM4, Lykkesfeldt J1, Fledelius C. (PubMed)
(14) Non-Alcoholic Fatty Liver Disease by NICK G. (The American Liver Foundation)
(15) Racial and Ethnic Disparities in Nonalcoholic Fatty Liver Disease Prevalence, Severity, and Outcomes in the United States: A Systematic Review and Meta-analysis by Rich NE1, Oji S1, Mufti AR1, Browning JD1, Parikh ND2, Odewole M1, Mayo H3, Singal AG. (PubMed)
(16) Emerging Trends Conference: EMERGING TRENDS IN NON-ALCOHOLIC FATTY LIVER DISEASE by AASLD
(17) Hepatic Encephalopathy by the Canadian Liver Foundation
(18) LIVER DISEASE AND ASCITES by Sequana Medical
(19) Nonalcoholic fatty liver disease manifesting esophageal variceal bleeding by Tang CP1, Huang YS, Tsay SH, Chang FY, Lee SD. (PubMed)
(20) Non-alcoholic fatty liver disease by Genetic Home Reference. (NIH)
(21) Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis by J K Dowman,*† J W Tomlinson,‡ and P N Newsome. (PMC)
(22) Current treatment options for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis by Melanie D Beaton, MD FRCPC. (PMC)
(23) Herbal medicines and nonalcoholic fatty liver disease by Hong Yao, Yu-Jie Qiao, Ya-Li Zhao, Xu-Feng Tao, Li-Na Xu, Lian-Hong Yin, Yan Qi, and Jin-Yong Peng. (PMC)
(24) An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes by Ajda Ota and Nataša P. Ulrich. (PubMed)
(61) Popular #Herbs - Anise Kyle J. Norton
(62) Pimpinella anisum L. fruit: Chemical composition and effect on a rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
(63) Popular Herbs - Hawthorn (Crataegus)
(64) Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis by Shi KQ, Fan YC, Liu WY, Li LF, Chen YP, Zheng MH. (PubMed)
(65) The relationship between obesity and the severity of non-alcoholic fatty liver disease: systematic review and meta-analysis by Lu FB1, Hu ED1, Xu LM1, Chen L1, Wu JL1, Li H1, Chen DZ2, Chen YP. (PubMed)
(66) Sida rhomboidea. Roxb Leaf Extract Down-Regulates Expression of PPARγ2 and Leptin Genes in High Fat Diet-Fed C57BL/6J Mice and Retards in Vitro 3T3L1 Pre-Adipocyte Differentiation by Menaka C. Thounaojam,1 Ravirajsinh N. Jadeja,1 Umed V. Ramani,2 Ranjitsinh V. Devkar,1,*and A. V. Ramachandran. (PMC)
(67) Prevention of High Fat Diet-Induced Insulin Resistance in C57BL/6J Mice by Sida rhomboidea ROXB. Extract by Menaka Chanu Thounaojam, Ravirajsinh Navalsinh Jadeja, Ansarullah, Ranjitsinh Vijaysinh Devkar, A. V. Ramachandran. (Journal of Health Science)
(68) Sida rhomboidea. Roxb Leaf Extract Down-Regulates Expression of PPARγ2 and Leptin Genes in High Fat Diet-Fed C57BL/6J Mice and Retards inVitro 3T3L1 Pre-Adipocyte Differentiation
Menaka C. Thounaojam 1, Ravirajsinh N. Jadeja 1, Umed V. Ramani 2, Ranjitsinh V. Devkar 1,* and. V. Ramachandran. ( International Journal of Molecular Science)
(69) Phytochemistry and medicinal properties of Teucrium polium L. (Lamiaceae) by Bahramikia S1, Yazdanparast R. (PubMed)
(70) Teucrium polium in the prevention of steatohepatitis in rats by Rahim Amini, Narges Nosrati, Razieh Yazdanparast, Mahsa Molaei. ( Liver International)
(71) Teucrium polium reversed the MCD diet-induced liver injury in rats by Rahim Amini, Razieh Yazdanparast and Safiyeh Aghazadeh. (Sage Journal)
(72) Popular Herbs - Grapefruit Seed Extract by Kyle J. Norton
(73) Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase by Shang J1, Chen LL, Xiao FX, Sun H, Ding HC, Xiao H. (PubMed)
(74) SIRT1 as a potential therapeutic target for the treatment of nonalcoholic fatty liver disease by Colak Y1, Ozturk O, Senates E, Tuncer I, Yorulmaz E, Adali G, Doganay L, Enc FY. (PubMed)
(75) Popular #Herbs - Milk Thistle by Kyle J. Norton
(76) The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease: A meta-analysis (PRISMA) of randomized control trials by Zhong S1, Fan Y, Yan Q, Fan X, Wu B, Han Y, Zhang Y, Chen Y, Zhang H, Niu J. (PubMed)
(77) Silybum marianum oil attenuates hepatic steatosis and oxidative stress in high fat diet-fed mice by Zhu SY1, Jiang N2, Yang J3, Tu J4, Zhou Y3, Xiao X3, Dong Y. (PubMed)
(78) Popular #Herbs - #Ginseng, Asian (Panax ginseng) and Ginseng, North America by Kyle J. Norton
(79) Acanthopanax senticosus Extract Prepared from Cultured Cells Decreases Adiposity and Obesity Indices in C57BL/6J Mice Fed a High Fat Diet by Youn-Soo Cha, Soon-Jae Rhee, and Young-Ran Heo. (Journal of Medicinal Food)
(80) Acanthopanax senticosus reverses fatty liver disease and hyperglycemia in ob/ob mice by Sang, Hyun Park, Sang Gil Lee, Sung Keel Kang, and Sung Hyun Chung. (Springer Link)
(81) Chinese Herbs – Ze Xie by Kyle J. Norton
(82) Protective effects of the Alisma Orientalis extract on the experimental nonalcoholic fatty liver disease byXuezhi Hong, Huiqing Tang, Limao Wu, and Lianda Li. (Wiley Online Library)
(83) Cissus quadrangularis by Wikipedia
(84) Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease by Chidambaram, Jaya, Carani Venkatraman, and Anuradha. (Science Direct)
(85) Cissus quadrangularis - Wikipedia
(86) Clerodendron glandulosum Coleb., Verbenaceae, ameliorates high fat diet-induced alteration in lipid and cholesterol metabolism in rats by Jadeja RN; Thounaojam MC; Ansarullah; Devkar RV*; Ramachandran AV. (Scielo)
(87) Popular #Herbs - Turmeric (Curcuma longa) by Kyle J. Norton
(88) NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet by Amato A1, Caldara GF2, Nuzzo D3, Baldassano S4, Picone P5, Rizzo M6, Mulè F7, Di Carlo M. (PubMed)
(89) Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases by Navekar R1, Rafraf M1, Ghaffari A1, Asghari-Jafarabadi M2, Khoshbaten M. (PubMed)
(90) Popular Herbs - Ginkgo biloba by Kyle J. Norton
(91) Inhibitory effect of Ginkgo biloba extract on fatty liver: Regulation of carnitine palmitoyltransferase 1a and fatty acid metabolism by Shi Dong Wang, Zuoquan Xie, Jia Chen, and Ke Wang. (Research Gate)
(92) Superfoods - Flaxseed oil by Kyle J. Norton
(93) Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men by Fukumitsu S1, Aida K, Shimizu H, Toyoda K. (PubMed)
(94) Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but the magnitude of the effect depends on food type by Kristensen M1, Jensen MG, Aarestrup J, Petersen KE, Søndergaard L, Mikkelsen MS, Astrup A. (PubMed)
(95) A comprehensive review on Nymphaea stellata: A traditionally used bitter by M. K. Mohan Maruga Raja, Neeraj Kumar Sethiya, and S. H. Mishra. (PMC)
(96) Nelumbo nucifera alkaloid inhibits 3T3-L1 preadipocyte differentiation and improves high-fat-diet-induced obesity and body fat accumulation in rats by Xie Bin, Wan Jin, Wang Wenqing, and Shi Chunyang. (Research Gate)
(97) Improvement in High-Fat Diet-Induced Obesity and Body Fat Accumulation by a Nelumbo nucifera Leaf Flavonoid-Rich Extract in Mice by Cheng-Hsun Wu, Mon-Yuan Yang, Kuei-Chuan Chan, and Pei-Jun Chung. (Research Gate)
Phytchoemical Alliin Gobbles Up Cancer Cells in Vivo with No Side Effects
Cancer is a class of disease caused by irregular cell growth in the tissue or organ associated with the alternation of cell DNA.
Most cancers at the early stage, due to the small size of the tumor are asymptomatic, However, as the cells continue to proliferation, at some points, the tumor may affect the nearby blood vessels and nerve cell leading to symptoms of severe pain and bleeding accompanied by the general symptoms shared by all cancers.
Most primary cancers at the advanced stage can also travel a distance away from the original site to infect other healthy tissues, leading to a secondary metastasis.
According to the statistics provided by the National Cancer Institute, based on 2011–2015 statistics. approximately, 439.2 per 100,000 men and women per year are diagnosed with cancer. The number of cancer deaths is 163.5 per 100,000 men and women per year, also based on 2011–2015 statistics.
Cancers are classified depending on the types of cells alternation
* Carcinoma
Carcinoma is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands.
* Sarcoma
Sarcoma is a type of cancer that arises from malignantly connective tissue cells originated from embryonic germ cells or bone, cartilage, and fat tissues and cells.
* Lymphoma and leukemia
Hematopoietic cells are multipotent stem cells that give rise to all types of the blood cell, including red blood cells, white blood cells, and platelets become cancerous.
* Germ cell tumor
The cancer is derived from pluripotent cells. In adults, these are most often found in the testicle and ovary, However, the cancer is more common in babies and young children.
* Blastoma
The cancer is derived from immature "precursor" or embryonic tissue. These are also most common in children.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential treatment of cancer with no side effect, researchers examined the protective effect of three garlic powder compared to that alliin.
Rat selected to the study were administered for 2 weeks with 5% garlic powder diet.
According to the comet assay, consumption of the different garlic powders induced a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.
Compared to the other garlic powders increased alliin content of the garlic powder was associated strongly with a proportional decrease in NDMA induced DNA alteration.
In other words, alliin increased anti-liver cancer activity of garlic powder proportionally compared to normal garlic powders.
Interestingly, DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon were also decreased strongly by the three garlic powders but these decreases were not correlated to the alliin content of the garlic powder.
In other words, all phytochemical compounds found in the garlic powder must work together to augment the anti-cancer effect regardless of the content of the individual compound.
In the study of liver cancer induced by injections of 0.025 mg/kg body weight aflatoxin B1 (AFB1) in rats, researchers garlic powder decreased the appearance and size of hepatic GST-P foci associated with early markers of the liver cancer.
However, garlic containing the highest level of alliin showed a stronger effect in the protection of liver against the forming hepatic GST-P foci compared to the normal garlic powders.
Levels of alliin showed an inverse associated with the number and area of preneoplastic foci.
Garlic powder ingestion increased the activity of hepatic detoxified enzymes such as glutathione S-transferase and UDP glucuronosyltransferase with no modification of nifedipine oxidase activity.
Dr. Bergès R, the lead researchers said, "It is suggested that garlic partly exerts its anticarcinogenic effects through increasing enzymes involved in AFB1 detoxification. This study highlights the possibility of controlling the cultivation conditions to improve the chemopreventive efficacy of garlic".
Taken altogether, alliin may be considered supplements for the prevention and treatment of cancer with no side effect, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats by Bergès R1, Siess MH, Arnault I, Auger J, Kahane R, Pinnert MF, Vernevaut MF, le Bon AM. (PubMed)
Most cancers at the early stage, due to the small size of the tumor are asymptomatic, However, as the cells continue to proliferation, at some points, the tumor may affect the nearby blood vessels and nerve cell leading to symptoms of severe pain and bleeding accompanied by the general symptoms shared by all cancers.
Most primary cancers at the advanced stage can also travel a distance away from the original site to infect other healthy tissues, leading to a secondary metastasis.
According to the statistics provided by the National Cancer Institute, based on 2011–2015 statistics. approximately, 439.2 per 100,000 men and women per year are diagnosed with cancer. The number of cancer deaths is 163.5 per 100,000 men and women per year, also based on 2011–2015 statistics.
Cancers are classified depending on the types of cells alternation
* Carcinoma
Carcinoma is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands.
* Sarcoma
Sarcoma is a type of cancer that arises from malignantly connective tissue cells originated from embryonic germ cells or bone, cartilage, and fat tissues and cells.
* Lymphoma and leukemia
Hematopoietic cells are multipotent stem cells that give rise to all types of the blood cell, including red blood cells, white blood cells, and platelets become cancerous.
* Germ cell tumor
The cancer is derived from pluripotent cells. In adults, these are most often found in the testicle and ovary, However, the cancer is more common in babies and young children.
* Blastoma
The cancer is derived from immature "precursor" or embryonic tissue. These are also most common in children.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential treatment of cancer with no side effect, researchers examined the protective effect of three garlic powder compared to that alliin.
Rat selected to the study were administered for 2 weeks with 5% garlic powder diet.
According to the comet assay, consumption of the different garlic powders induced a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.
Compared to the other garlic powders increased alliin content of the garlic powder was associated strongly with a proportional decrease in NDMA induced DNA alteration.
In other words, alliin increased anti-liver cancer activity of garlic powder proportionally compared to normal garlic powders.
Interestingly, DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon were also decreased strongly by the three garlic powders but these decreases were not correlated to the alliin content of the garlic powder.
In other words, all phytochemical compounds found in the garlic powder must work together to augment the anti-cancer effect regardless of the content of the individual compound.
In the study of liver cancer induced by injections of 0.025 mg/kg body weight aflatoxin B1 (AFB1) in rats, researchers garlic powder decreased the appearance and size of hepatic GST-P foci associated with early markers of the liver cancer.
However, garlic containing the highest level of alliin showed a stronger effect in the protection of liver against the forming hepatic GST-P foci compared to the normal garlic powders.
Levels of alliin showed an inverse associated with the number and area of preneoplastic foci.
Garlic powder ingestion increased the activity of hepatic detoxified enzymes such as glutathione S-transferase and UDP glucuronosyltransferase with no modification of nifedipine oxidase activity.
Dr. Bergès R, the lead researchers said, "It is suggested that garlic partly exerts its anticarcinogenic effects through increasing enzymes involved in AFB1 detoxification. This study highlights the possibility of controlling the cultivation conditions to improve the chemopreventive efficacy of garlic".
Taken altogether, alliin may be considered supplements for the prevention and treatment of cancer with no side effect, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats by Bergès R1, Siess MH, Arnault I, Auger J, Kahane R, Pinnert MF, Vernevaut MF, le Bon AM. (PubMed)
Friday, May 10, 2019
Ginger, the Potential Remedy for the Prevention and Treatment of Head and Neck Cancer, According to Studies
Head and neck cancer is a class of cancer including the mouth, nose, throat, larynx, sinuses, or salivary glands.
Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organ, leading to secondary metastasis.
The exact causes of head and neck cancer are unknown. However, certain risk factors have been found to associate with the onset of the disease, including, excessive alcohol intake, smoking, infected by the HPV virus, poor oral health, race, long-term exposure to wood dust.
Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.
According to the statistics, in the US, HPV is the most common sexually transmitted virus.
Dr. Ankit Shah, the lead scientist in the examination of oral sex and human papillomavirus-related head and neck squamous cell cancer, wrote, "Unprotected sexual behaviors with the HPV carrier plays an important role in the transmission of this virus".
And, "The global incidence of head and neck cancers is declining, but the incidence of HPV related head and neck cancers is rapidly increasing over the last few decades".
Unfortunately, the doctor team continued, "However, most institutions do not mandate documentation of sexual history or counseling of patients regarding sexual practices like they do for tobacco and alcohol addictions in HNSCC patients".
The results strongly suggested that HPV can transmit and cause head and neck cancer.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural remedy for the treatment of head and neck cancer examined the two major pharmacologically active compounds of ginger, 6-gingerol, and 6-shogaol on head and neck cancer cell lines.
According to assays, injection of 6-gingerol, and 6-shogaol showed a dose-dependent reduction of cancer cell viability and induced cancer cells apoptosis.
Furthermore, according to the Western blot analysis, injection of ginger also suppressed the protein associated with the antiapoptotic activity, namely the survivin.
Combination of 6-shogaol with cisplatin also showed a synergistic reduction of clonogenic survival.
The results strongly suggested that ginger inhibits head and neck cancer cells through degradation and apoptosis.
Moreover, in order to reveal more information about ginger anti-cancer effects, researchers evaluated
the 1'-Acetoxychavicol acetate (ACA), extracted from rhizomes of tropical ginger against human head and neck squamous cell carcinoma cell line HN4.
Application of ACA exerted significantly inhibited activity against the growth of human head and neck squamous cell carcinoma cell line HN4 and induced cell apoptosis.
The efficacy of ACA was associated with the inhibition of the expression of miR-23a, which has been found to promote growth and suppress apoptosis in HN4 cells.
Under the transfection process, ginger demonstrated a strong anti-miR-23a activity by stimulating the inhibition of the proliferation of HN4 cells and inducing cell apoptosis.
Where miR-23a is an RNA gene which can repress tumor suppressor phosphatase and tensin homolog (PTEN) for the growth of the tumor.
Taken altogether, ginger processed major active compounds may be considered a functional remedy for the prevention and treatment of head and neck cancer, pending to the confirmation of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) 6-shogaol induces apoptosis and enhances radiosensitivity in head and necksquamous cell carcinoma cell lines by Kotowski U1, Kadletz L1, Schneider S1, Foki E1, Schmid R2, Seemann R3, Thurnher D4, Heiduschka G. (PubMed)
(2) MicroRNAs contribute to the anticancer effect of 1'-acetoxychavicol acetate in human head and neck squamous cell carcinoma cell line HN4 byWang H1, Shen L, Li X, Sun M. (PubMed)
(3) Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature by Ankit Shah, Akshat Malik, Apurva Garg, Manish Mair, Sudhir Nair, and Pankaj Chaturvedi. (BMJ Journal)
Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organ, leading to secondary metastasis.
The exact causes of head and neck cancer are unknown. However, certain risk factors have been found to associate with the onset of the disease, including, excessive alcohol intake, smoking, infected by the HPV virus, poor oral health, race, long-term exposure to wood dust.
Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.
According to the statistics, in the US, HPV is the most common sexually transmitted virus.
Dr. Ankit Shah, the lead scientist in the examination of oral sex and human papillomavirus-related head and neck squamous cell cancer, wrote, "Unprotected sexual behaviors with the HPV carrier plays an important role in the transmission of this virus".
And, "The global incidence of head and neck cancers is declining, but the incidence of HPV related head and neck cancers is rapidly increasing over the last few decades".
Unfortunately, the doctor team continued, "However, most institutions do not mandate documentation of sexual history or counseling of patients regarding sexual practices like they do for tobacco and alcohol addictions in HNSCC patients".
The results strongly suggested that HPV can transmit and cause head and neck cancer.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural remedy for the treatment of head and neck cancer examined the two major pharmacologically active compounds of ginger, 6-gingerol, and 6-shogaol on head and neck cancer cell lines.
According to assays, injection of 6-gingerol, and 6-shogaol showed a dose-dependent reduction of cancer cell viability and induced cancer cells apoptosis.
Furthermore, according to the Western blot analysis, injection of ginger also suppressed the protein associated with the antiapoptotic activity, namely the survivin.
Combination of 6-shogaol with cisplatin also showed a synergistic reduction of clonogenic survival.
The results strongly suggested that ginger inhibits head and neck cancer cells through degradation and apoptosis.
Moreover, in order to reveal more information about ginger anti-cancer effects, researchers evaluated
the 1'-Acetoxychavicol acetate (ACA), extracted from rhizomes of tropical ginger against human head and neck squamous cell carcinoma cell line HN4.
Application of ACA exerted significantly inhibited activity against the growth of human head and neck squamous cell carcinoma cell line HN4 and induced cell apoptosis.
The efficacy of ACA was associated with the inhibition of the expression of miR-23a, which has been found to promote growth and suppress apoptosis in HN4 cells.
Under the transfection process, ginger demonstrated a strong anti-miR-23a activity by stimulating the inhibition of the proliferation of HN4 cells and inducing cell apoptosis.
Where miR-23a is an RNA gene which can repress tumor suppressor phosphatase and tensin homolog (PTEN) for the growth of the tumor.
Taken altogether, ginger processed major active compounds may be considered a functional remedy for the prevention and treatment of head and neck cancer, pending to the confirmation of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) 6-shogaol induces apoptosis and enhances radiosensitivity in head and necksquamous cell carcinoma cell lines by Kotowski U1, Kadletz L1, Schneider S1, Foki E1, Schmid R2, Seemann R3, Thurnher D4, Heiduschka G. (PubMed)
(2) MicroRNAs contribute to the anticancer effect of 1'-acetoxychavicol acetate in human head and neck squamous cell carcinoma cell line HN4 byWang H1, Shen L, Li X, Sun M. (PubMed)
(3) Oral sex and human papilloma virus-related head and neck squamous cell cancer: a review of the literature by Ankit Shah, Akshat Malik, Apurva Garg, Manish Mair, Sudhir Nair, and Pankaj Chaturvedi. (BMJ Journal)
Bioactive Compound 3,3'-Diindolylmethane Protects the Neurons Integrityand Viability Against Autoimmune Encephalomyelitis
Autoimmune encephalitis is a group of conditions caused by the body's immune system mistakenly attacks healthy brain cells.
Autoimmune encephalitis has been found to induce neurologic symptoms such as impaired memory and cognition, abnormal movements, seizures, and/or psychiatric symptoms such as aggression, inappropriate sexual behaviors, panic attacks.
Autoimmune encephalitis can be classified into
* Post-infectious encephalitis or acute disseminated encephalomyelitis (ADEM) are the conditions caused by an infection. In these cases, the immune system not only attacks the pathogens which cause infection it also destroys mistakenly the healthy cells in the brain.
Methylprednisolone is the first line of drug for the treatment of post-infectious encephalitis, if it failures, plasma exchange or intravenous immunoglobulin may be used.
* Other forms of autoimmune encephalitis are caused by the specific antibodies in the blood produced by the immune system that attack the brain cells.
According to the Autoimmune Encephalitis Alliance, a number of options are available to treat AE, the first line option include including medication that decreases the inflammatory response to antibodies, and intravenous immunoglobulin (IVIG); to increase removal of antibodies, inhibit binding of the harmful antibodies.
If the first line option failure, immune suppressive medicine may be used as a second line of treatment, including Rituximab, CellCept, and Cytoxan (Cyclophosphamide).
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
With an aim to find a potential ingredient for the treatment of autoimmune encephalomyelitis, researchers evaluated the 3,3'-Diindolylmethane (DIM) effects on the regulation of activated T cells during the development of experimental autoimmune encephalomyelitis (EAE).
During the experiment, administration of DIM 10 days after EAE was effective in ameliorating disease parameters, including inflammation and central nervous system cellular infiltration.
According to the microRNA (miRNA) microarray analysis, post-treatment of DIM alter the expression of miRNA profile in brain infiltrating CD4(+) T cells, an indication of autoimmune dysfunction on EAE mice.
Observed by the bioinformatics analysis, the efficacy of DIM-altered the miRNAs expression associated with pathways that halt cell cycle progression and promote apoptosis.
Particularly, DIM impacted these cellular processes in activated T cells.
More precisely, DIM protected the brain against the immune dysfunction in attacking the brain cell in the forming of autoimmune encephalomyelitis, by activating and suppressing the micro genes- induced immune dysfunction of EAE.
Dr. the lead scientist, after taking into account co and confounders wrote, "these studies demonstrate that DIM post-treatment leads to the amelioration of EAE development by suppressing T-cell responses through the induction of select miRNAs that control cell cycle progression and mediate apoptosis".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of autoimmune encephalomyelitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways by Rouse M1, Rao R1, Nagarkatti M1, Nagarkatti PS. (PubMed)
(2) Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells by Rouse M1, Singh NP, Nagarkatti PS, Nagarkatti M. (PubMed)
Autoimmune encephalitis has been found to induce neurologic symptoms such as impaired memory and cognition, abnormal movements, seizures, and/or psychiatric symptoms such as aggression, inappropriate sexual behaviors, panic attacks.
Autoimmune encephalitis can be classified into
* Post-infectious encephalitis or acute disseminated encephalomyelitis (ADEM) are the conditions caused by an infection. In these cases, the immune system not only attacks the pathogens which cause infection it also destroys mistakenly the healthy cells in the brain.
Methylprednisolone is the first line of drug for the treatment of post-infectious encephalitis, if it failures, plasma exchange or intravenous immunoglobulin may be used.
* Other forms of autoimmune encephalitis are caused by the specific antibodies in the blood produced by the immune system that attack the brain cells.
According to the Autoimmune Encephalitis Alliance, a number of options are available to treat AE, the first line option include including medication that decreases the inflammatory response to antibodies, and intravenous immunoglobulin (IVIG); to increase removal of antibodies, inhibit binding of the harmful antibodies.
If the first line option failure, immune suppressive medicine may be used as a second line of treatment, including Rituximab, CellCept, and Cytoxan (Cyclophosphamide).
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
With an aim to find a potential ingredient for the treatment of autoimmune encephalomyelitis, researchers evaluated the 3,3'-Diindolylmethane (DIM) effects on the regulation of activated T cells during the development of experimental autoimmune encephalomyelitis (EAE).
During the experiment, administration of DIM 10 days after EAE was effective in ameliorating disease parameters, including inflammation and central nervous system cellular infiltration.
According to the microRNA (miRNA) microarray analysis, post-treatment of DIM alter the expression of miRNA profile in brain infiltrating CD4(+) T cells, an indication of autoimmune dysfunction on EAE mice.
Observed by the bioinformatics analysis, the efficacy of DIM-altered the miRNAs expression associated with pathways that halt cell cycle progression and promote apoptosis.
Particularly, DIM impacted these cellular processes in activated T cells.
More precisely, DIM protected the brain against the immune dysfunction in attacking the brain cell in the forming of autoimmune encephalomyelitis, by activating and suppressing the micro genes- induced immune dysfunction of EAE.
Dr. the lead scientist, after taking into account co and confounders wrote, "these studies demonstrate that DIM post-treatment leads to the amelioration of EAE development by suppressing T-cell responses through the induction of select miRNAs that control cell cycle progression and mediate apoptosis".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of autoimmune encephalomyelitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane ameliorates experimental autoimmune encephalomyelitis by promoting cell cycle arrest and apoptosis in activated T cells through microRNA signaling pathways by Rouse M1, Rao R1, Nagarkatti M1, Nagarkatti PS. (PubMed)
(2) Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells by Rouse M1, Singh NP, Nagarkatti PS, Nagarkatti M. (PubMed)
Plant-based Chemical Betanin Kills Cancer Cells in Vitro
Cancer is the class of diseases associated with cell growth, disorderly and uncontrollably due to the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved the onset of cancer.
However, most people with some of the aforementioned risk factors have never developed cancer.
Some researchers suggested that the rise of cancers in the obese individual may correlate to the promotion of the Western diet over the past few decades.
Dr.Timothy J Key, the lead scientist wrote, "Diet-related factors are thought to account for about 30% of cancers in developed countries. Obesity increases the risk of cancers in the esophagus, colorectum, breast, endometrium, and kidney. Alcohol causes cancers of the oral cavity, pharynx, larynx, esophagus, and liver, and causes a small increase in the risk of breast cancer".
And, "Adequate intakes of fruit and vegetables probably lower the risk for several types of cancer, especially cancers of the gastrointestinal tract".
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a natural ingredient which reduces the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues, researchers examined betanin (BET) effect in the co-administration with them.
In the study to overcome the restrictions of BET, researchers designed a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) for the DOX and BET loading capacity of 20.5% and 16.25%, respectively).
Injection of DOX@BET loaded PGNPs decreased the significant cell viability amount of breast cancer cells (MCF-7) compared to the treatment of the free form of DOX or BET.
In other words, the newly designed combination kills induce a higher percentage of cell death compared to the use of DOX or BET individually.
Sadly, the study did not confirm the combination reduced the side effect caused by DOX during the experiment.
Dr. Javadi B in the examination of herbal plants for the treatment of breast cancer showed that beetroot (Beta vulgris) induced cancer death by cytotoxicity without affecting the nearby healthy cells.
He continued, "additional pharmacological studies and clinical trials are needed to elucidate their molecular and cellular mechanisms of actions, frequency, and amount of consumption, possible adverse effects, and optimum preparation methods.".
Taken altogether, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine by Javadi B. (PubMed)
(3) The effect of diet on risk of cancer by Dr. Timothy J Key, Naomi E Allen, Elizabeth A Spencer,
Ruth C Travis. (The Lancet)
Most cases of cancer begin in the cells on the surface of the inner lining tissues of organ or gland. At the early stage, most cancers are asymptomatic.
However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.
Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.
According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.
The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormones therapy, use of immunosuppression are some of the prevalent factors involved the onset of cancer.
However, most people with some of the aforementioned risk factors have never developed cancer.
Some researchers suggested that the rise of cancers in the obese individual may correlate to the promotion of the Western diet over the past few decades.
Dr.Timothy J Key, the lead scientist wrote, "Diet-related factors are thought to account for about 30% of cancers in developed countries. Obesity increases the risk of cancers in the esophagus, colorectum, breast, endometrium, and kidney. Alcohol causes cancers of the oral cavity, pharynx, larynx, esophagus, and liver, and causes a small increase in the risk of breast cancer".
And, "Adequate intakes of fruit and vegetables probably lower the risk for several types of cancer, especially cancers of the gastrointestinal tract".
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a natural ingredient which reduces the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues, researchers examined betanin (BET) effect in the co-administration with them.
In the study to overcome the restrictions of BET, researchers designed a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) by (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) for the DOX and BET loading capacity of 20.5% and 16.25%, respectively).
Injection of DOX@BET loaded PGNPs decreased the significant cell viability amount of breast cancer cells (MCF-7) compared to the treatment of the free form of DOX or BET.
In other words, the newly designed combination kills induce a higher percentage of cell death compared to the use of DOX or BET individually.
Sadly, the study did not confirm the combination reduced the side effect caused by DOX during the experiment.
Dr. Javadi B in the examination of herbal plants for the treatment of breast cancer showed that beetroot (Beta vulgris) induced cancer death by cytotoxicity without affecting the nearby healthy cells.
He continued, "additional pharmacological studies and clinical trials are needed to elucidate their molecular and cellular mechanisms of actions, frequency, and amount of consumption, possible adverse effects, and optimum preparation methods.".
Taken altogether, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Diet Therapy for Cancer Prevention and Treatment Based on Traditional Persian Medicine by Javadi B. (PubMed)
(3) The effect of diet on risk of cancer by Dr. Timothy J Key, Naomi E Allen, Elizabeth A Spencer,
Ruth C Travis. (The Lancet)
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