Regular Walking, The Easy Way for age 50 plus to Diseases Free of Age

Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but regular walking in the younger elderly with contribution to longevity, diseases free and successful aging have not been studied.


According to the Hokkaido University Graduate School of Medicine, in the assessment of 1239 community-dwelling men aged 64/65 years, moderated walking showed to induce longevity and happy aging(1) with or without major critical diseases such as heart disease, cerebrovascular disease, or cancer.
In fact, in the 1990 study of 20,004 men and 21,159 women in Miyagi Prefecture in rural northern Japan (40-64 year of age) regular walking reduces the risk for all-cause mortality, particular among nonsmoking men and women(2).

Dr. Fortes C and colleagues at the joint study led by London School of Hygiene & Tropical Medicine said, " elderly people walking at open air for four times weekly had 40% decreased the risk of mortality" and " supports the encouragement of physical activity in advanced age for increasing longevity"(3). And high levels of walking activity are associated with better survival insisted by the Catholic University of Sacred Heart(4).

There is always a concern of elderly and caregivers regarded to the degeneration of cartilage in the advanced age in contribution to arthritic-inflammatory diseases(5). As the degeneration of cartilage due to aging may make cartilage more brittle, less elastic and less wearable. leading to the disease of bone and injuring the bone easily(6).

Over weight and obesity are found to associate the risk factors and risks of rapid progression of the disease(7)(8). In the discussion of obesity versus osteoarthritis, Dr. Sartori-Cintra AR and the research team at Universidade Estadual de Campinas, indicated that obesity is associated to wide range of diseases, such as osteometabolic diseases, including osteoporosis and osteoarthritis and suggested that physical activity combined with changes in diet composition can reverse the inflammatory and leptin resistance, reducing progression or preventing the onset of osteoarthritis(9).

Glucosamine, a compound of the simple sugar glucose and the amino acid glutamine, is a precursor for glycosaminoglycans(10), a major component of joint cartilage(11). Intake of glucosamine sulfate, chondroitin sulfate, hyaluronic acid, collagen hydrolysate, or nutrients, such as antioxidants and omega-3 fatty acids showed to prevent cartilage degeneration and treat arthritis, according to study(11).

Without the concern of further damage to the cartilage, regular walking may lead you to a golden retirement with Diseases Free, passing Age of 100+.
For convenience, you may want to buy joint cartilage supplements from your local drug store to prevent cartilage degeneration

Kyle J. Norton does not receive a financial benefit from any nutritional supplement company,


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Health Benefits of Daily Walking on Mortality Among Younger-Elderly Men With or Without Major Critical Diseases in the New Integrated Suburban Seniority Investigation Project: A Prospective Cohort Study by Zhao W1, Ukawa S, Kawamura T, Wakai K, Ando M, Tsushita K, Tamakoshi A.(PubMed)
(2) Walking and mortality in Japan: the Miyagi Cohort Study by Fujita K1, Takahashi H, Miura C, Ohkubo T, Sato Y, Ugajin T, Kurashima K, Tsubono Y, Tsuji I, Fukao A, Hisamichi S.(PubMed)
(3) Walking four times weekly for at least 15 min is associated with longevity in a cohort of very elderly people by Fortes C1, Mastroeni S2, Sperati A3, Pacifici R4, Zuccaro P4, Francesco F5, Agabiti N5, Piras G5, Amleto D6, Ebrahim S7.(PubMed)
(4) Walking one hour or more per day prevented mortality among older persons: results from ilSIRENTE study. by Landi F1, Russo A, Cesari M, Pahor M, Liperoti R, Danese P, Bernabei R, Onder G(PubMed)
(5) Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis by Houard X1, Goldring MB, Berenbaum F.(PubMed)
(6) [FTIR spectroscopic investigations on the difference in cartilage composition between youth and elder].[Article in Chinese] by Chen W1, Zhou M, Zuo J, Wang LN, Gao SQ, Lu GH, Li ZL, Li ZW.(PubMed)
(7) Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis by Messier SP1, Gutekunst DJ, Davis C, DeVita P.(PubMed)
(8) Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis by Christensen R1, Bartels EM, Astrup A, Bliddal H.(PubMed)
(9) Obesity versus osteoarthritis: beyond the mechanical overload.[Article in English, Portuguese] by Sartori-Cintra AR1, Aikawa P2, Cintra DE3.(PubMed)
(10) Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP by Little PJ1, Drennon KD, Tannock LR.(PubMed)
(11) Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acid by Jörg Jerosch(PubMed)

Herbal Aloe Vera, the Anti Skin Aging Functional Remedy with NO Side Effects, According to Studies

Scientists may have found a natural and potent herbal plant used for the delay of skin aging, according to the studies.

Skin aging is a natural and biological process of the human which can be stopped.

Long-term free radical damage to the skin through oxidative stress is the major cause of skin aging.

Exposure to the sun (photoaging) and pollution, and loss of subcutaneous support (fatty tissue between your skin and muscle) are some of the risk factors associated with the skin aging.

Some researchers suggested that skin expression may be considered as a refect of the general health of an individual. An unhealthy skin due to skin nutritional deficiency has been a target by the dermatology and cosmetic industries.

Dr.Silke K. Schagen in the study that links between nutrition and skin aging, said, "Vitamins, carotenoids, tocopherols, flavonoids and a variety of plant extracts have been reported to possess potent antioxidant properties and have been widely used in the skin care industry either as topically applied agents or oral supplements in an attempt to prolong youthful skin appearance".

The results strongly suggested that by providing enough nutrition to the skin needs, extrinsic causes of skin aging can be delayed

In skin wrinkle, according to the results of the studies by the Monash University, Melbourne, a high intake of certain food groups are associated with the speeding up of wrinkle, including meat, dairy, and butter. High intake of vegetables, legumes and olive oil appeared to be protective against cutaneous actinic damage.


Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.

The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.


The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

With an aim to find a natural ingredient or whole food for the delay of skin aging researchers at the Seoul National University Boramae Hospital examined the effect of aloe gel on the clinical signs and biochemical changes of aging skin.

The experiment included 30 healthy female subjects over the age of 45 given 2 different doses (low-dose: 1,200 mg/d, high-dose: 3,600 mg/d) of aloe vera gel supplementation for 90 days with their baseline status as a control.


Aloe gel intake, the facial wrinkles improved significantly (p<0.05) in both groups, and facial elasticity improved in the lower-dose group.

The injection of the gel also increased the skin photoprotection and the type I procollagen mRNA levels in controlling the rate of procollagen synthesis.


The results were accompanied by the matrix (MMP-1) mRNA levels associated with the breaking down the interstitial collagens, types I, II, and III, particularly in the higher-dose group.


Type I procollagen was substantially increased throughout the dermis in Aloe treatment of the group.

Dr. Cho S, the lead scientist said, "Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression".

The Kyung Hee University Global Campus in the investigation of the effects of Aloe vera on ultraviolet (UV) irradiation induces photo-damage of the skin, which in turn causes depletion of the dermal extracellular matrix and chronic alterations in skin structure.


By the comparison of the baby Aloe shoot extract (BAE, immature aloe extract), which is from the one-month-old shoots of Aloe vera, and adult aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, protective effect on UVB-induced skin photoaging in normal human dermal fibroblasts (NHDFs). researchers found that NHDF cells treated UVB-irradiation suppressed the matrixes associated with the breaking down the interstitial collagens, types I, II, and III, and the levels of inflammatory cytokines similar to that of the above study, compared to the AE-treated cells.
BAE treatment elevated type I procollagen which was reduced in photodamaged skin. mediated by the increasing levels of TGF-β1 levels which is a multifunctional cytokine.


The findings clearly suggested that herbal Aloe vera may be considered an anti-aging functional remedy with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.




References
(1) Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. by Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH. (PubMed)
(2) A Comparative Study of Baby Immature and Adult Shoots of Aloe Veraon UVB-Induced Skin Photoaging in vitro. by Hwang E, Kim SH, Lee S, Lee CH, Do SG, Kim J, Kim SY. (PubMed)
(3) Innovations in natural ingredients and their use in skin care.
(4) Discovering the link between nutrition and skin aging by Silke K. Schagen, † Vasiliki A. Zampeli, † Evgenia Makrantonaki, and Christos C. Zouboulis. (PMC)
(5) Skin wrinkling: can food make a difference? by Purba MB1, Kouris-Blazos A, Wattanapenpaiboon N, Lukito W, Rothenberg EM, Steen BC, Wahlqvist ML. (PubMed)
(6) Prevalence of Helicobacter pylori Infection in Patients with Peptic Ulcer Diseases and Non-Ulcer Dyspepsia by Hyo Rang Lee, M.D., Ki Soo Han, M.D., Byung Chul Yoo, M.D., and Sill Moo Park, M.D. (PMC)

Phytochemical 3,3'-Diindolylmethane Processes Hepatic Protective Activity

Scientists may have found a bioactive ingredient which processes liver protective activity with no side effects, according to studies.

Hepatic protection is an action in which substances including medicine and herbal remedy were used to protect the liver against damage.

The liver is the largest internal organ with a function which filters the blood from the intestinal tract before passing them to the heart and other parts of the body.

Additonally, the liver also produces bile to aid digestion and cholesterol to build strong cell membranes, production of vitamin D and steroid hormones.

Liver disease is a broad term included any problems that cause the reduced function of the liver.

There are many risk factors that liver problems. Most cases of liver disease are diagnosed in the advanced stage, it takes years to develop.

In other words, symptoms of liver disease can be felt only after more than 75% liver is damage.

Most common risk factors are a genetic preposition, viruses, and long-term excessive alcohol drinking.

Non-alcoholic fatty disease (NAFLD), a leading cause of cirrhosis, is one of the most common liver disease found in the Western world, affecting up to 25% of people in the United States.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

In the urgency of finding a natural compound with liver protective activity, researchers examined the pharmacokinetics of I3C and its derivatives, including 3,3'-Diindolylmethane or DIM multiple protective roles in the processes of chronic liver diseases.

Administration of I3C and its derivatives relieved liver oxidative stress by regulating transcriptional factors and their respective signaling pathways associated with the synthesis of DNA to influence the activation, proliferation, and apoptosis of target cells.

Furthermore, indoles not only modulated the enzymes that are relevant to hepatitis viral replication, lipogenesis, and the metabolism associated with liver function but also protected the liver against hepatotoxicity (ethanol and some hepatotoxic substances).

In other words, the indoles exerted hepatoprotection by inhibiting pro-inflammatory cytokines and chemokines against microbial-induced liver injuries.

Based on the findings, Dr. Wang SQ, the lead scientist said, "Indoles, especially I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".

And, " I3C and DIM as phytochemicals, exert anti-fibrosis, anti-tumor, anti-oxidant, immunomodulatory, detoxification and anti-inflammation effects on hepatic protection through pleiotropic mechanism".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of liver diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection by Wang SQ, Cheng LS, Liu Y, Wang JY, Jiang W. (PubMed)
(2) Induction of hepatic CYP1A by indole-3-carbinol in protection against aflatoxin B1 hepatocarcinogenesis in rainbow trout by Takahashi N1, Stresser DM, Williams DE, Bailey GS. (PubMed)

Herbal Artichoke Normalizes the Levels of Serum Cholesterol in Vivo and Human Study

Hyperlipidemia is a chronic condition of abnormally high blood cholesterol in the bloodstream.

Cholesterol is a waxy substance produced by the liver or dietary intake that processes a significant activity in the improvement of the digestive system by breaking down food, in the production of vitamin D and steroid hormone, particularly in the building of strong cell membranes.

There are 2 types of cholesterol. The low-density lipoprotein is also known as bad cholesterol which performs the aforementioned activity in the right levels and high-density lipoprotein which returns cholesterol back to the liver for reuse.

However, overexpression of cholesterol can cause plaque building up on the arterial wall, leading to arterial narrowing, wall stiffness, and hardening, some major causes of heart disease and stroke.

According to the free radical theory, overexpression of cholesterol also increases the risk of lipid peroxidation, leading to the onset of various diseases.

Dr, Yagi K, at the Institute of Applied Biochemistry in the analysis of the lipid peroxides and human diseases, said, "The lipid peroxidation (LPO) products are highly reactive and display marked biological effects, which, depending upon their concentration, cause selective alterations in cell signaling, protein and DNA damage, and cytotoxicity"

And. "Increased formation of lipid peroxides and aldehydes has been observed in atherosclerosis, ischemia-reperfusion, heart failure, Alzheimer’s disease, rheumatic arthritis, cancer, and other immunological disorders".

The findings clearly suggested that your risk of diseases is increased substantially if you have abnormally high blood cholesterol.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on the finding a natural therapeutics for the treatment of abnormal blood cholesterol, researchers examined artichoke leaf extract (ALE) activity in lowering the plasma total and non-HDL cholesterol by increasing fecal excretion of neutral bile acids and sterols.

The study included 64 Golden Syrian hamsters (8 weeks old) fed control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.

There were no significant changes for total cholesterol, HDL, non-HDL cholesterol triglycerides or fecal neutral sterols and bile acids were after 21 days for ALE-fed animals compared with controls.

However, ALE-fed male hamsters had significantly lower total cholesterol (15%), non-HDL cholesterol (30%) and triglycerides (22%) and female hamsters fed ALE showed reductions of 15% for total cholesterol, 29% for non-HDL cholesterol and 29% for triglycerides compared with controls after 42 days.


Furthermore, the total neutral sterol and bile acids concentrations also increased significantly by 50% and 53% in fecal samples of ALE fed males, and 82.4% and 25% in ALE fed females compared with controls.

Dr. Qiang Z, after taking into account other factors, said, "he ALE lowered hamster plasma cholesterol levels by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days".

In order to reveal more information about artichoke anti-high blood cholesterol property, researchers evaluated the effects of artichoke leaf extract (ALE) supplementation (250 mg, 2 b.i.d.) on the lipid pattern,

The randomized, double-blind, placebo-controlled clinical trial included 92 overweight subjects with primary mild hypercholesterolemia for 8 weeks.

46 subjects were randomized to supplementation (age: 54.2 ± 6.6 years, body mass index (BMI): 25.8 ± 3.9 kg/m(2), male/female: 20/26) and 46 subjects to placebo (age: 53.8 ± 9.0 years, BMI: 24.8 ± 1.6 kg/m(2), male/female: 21/25).


Artichoke leaf extract (ALE) supplementation was associated with a significant increase in mean high-density lipoprotein (HDL)-cholesterol (p < 0.001) and in mean change in HDL-cholesterol (HDL-C) (p = 0.004).


Moreover, ALE also significantly decreased the mean change in total cholesterol (p = 0.033), low-density lipoprotein (LDL)-cholesterol (p < 0.001), total cholesterol/HDL ratio (p < 0.001) and LDL/HDL ratio (p < 0.001) comapred to control.


The findings clearly supported the use of artichoke leaf extract ALE for the treatment of patients with mild high blood cholesterol.

Taken altogether, artichoke may be considered a functional formula for the treatment of patients with high blood cholesterol with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S.(PubMed)
(2) Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial by Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E. (PubMed)
(3) Lipid Peroxidation Products in Human Health and Disease by Kota V. Ramana,1 Sanjay Srivastava,2 and Sharad S. Singha. (Hindawi)

Bioactive Compound Sinigrin, the Dietary Source of Antioxidants

Antioxidants are stable molecules which inhibit oxidation. Antioxidants are either produced by the host or from the dietary sources.

Under normal condition, antioxidants produced by the body are good enough to counter the presence of free radicals in the body of a healthy individual.

However, in people with the weakened immune system or medical condition, intake of dietary antioxidants may be necessary due to depletion of the antioxidant enzymes.

Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order for them to maintain stable, they must either donate or intercept an electron from other molecules, leading a chain reaction that can not be stopped until they are either inhibited by antioxidant or electrons are paired.

Oxidative stress is an imbalance of the ratio of free radicals and antioxidant in the body caused by either overexpression of free radicals or depletion of antioxidant enzymes produced by the host.

Epidemiological studies suggested that oxidative stress has been found to cause lipid and protein and cellular damage, leading to the onset of chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

Out of many risk factors associated with the onset of oxidative stress, widespread obesity may be one of the major factors that contribute to the severity of the disease due to oxidative stress.


Dr. Keaney JF Jr said, "Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease".

Researchers on finding a natural ingredient which processes a strong antioxidant activity for the treatment of diseases associated with oxidative stress investigated the antioxidant property of sinigrin.

Injection of sinigrin suppressed the nitric oxide (NO) production, a free radical although is found to process many health benefits such as increased blood flow and blood vessel relaxation, reduced risk of CVD, and side effects such as induced oxidative stress causing neuro, kidney and liver toxicity by reducing the levels of nitric oxide synthase.

In rat study. oral administration of the compound also showed reduced the levels of urinary nitrate + nitrite and allyl isothiocyanate. In other words, sinigrin inhibited the production of free radicals expression through its antioxidant activity.

In non-alcoholic fatty liver disease (NAFLD), sinigrin exerted antioxidative stress potency by inhibiting lipid peroxidation, mitochondrial dysfunction and oxidative balance impairment (oxidative stress) in facilitating the progression of hepatic steatosis.

Mitochondrial dysfunction is found to interfere with the function of cells in the production of energy for cell or organ needs.

Oxidative balance impairment is another term of oxidative stress.

More precisely, it is caused by either overexpression of reactive oxygen species and/or depletion of antioxidant enzymes produced the host.

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of large sample size and multicenter human study.


However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant dietary approach in treatment of fatty liver: New insights and updates by Alessandra Ferramosca, Mariangela Di Giacomo, and Vincenzo Zara. (PMC)
(2) (1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (PubMed)
(3) Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study by Keaney JF Jr1, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ; Framingham Study. (PubMed)

Herbal Bilberry the Best for the Prevention and Treatment of Eye Disease

Eye disease is a general term of conditions associated with the damage of the optic nerve and impaired vision, including disease of the cornea and macular degeneration.

People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, people with eye disease at the advanced stage may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots.

If you have some of the aforementioned symptoms, you may have eye disease. Please make sure that you check with your doctor to rule out the possibility.

Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.

According to the statistics, the financial burden of vision loss and eye diseases and vision disorders in the U.S. has taken a toll on health care costs. Approximately, over $130 billion a year are spent to treat eye disease.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the urgency to find a natural source of the compound for the treatment of eye disease, particularly in the older population, researchers investigated the effects of bilberry anthocyanosides (Vaccinium myrtillus L.).

Bilberry anthocyanosides were found to promote rhodopsin, a biological pigment found in the rods of the retina synthesis and regeneration.


Moreover, the compounds increased retinal sensitivity to changes in light intensity and improved the visual acuity and dark adaptation and blood supply of the retina.

The findings support the regular use of bilberry anthocyanosides as a dietary source against the age-related macular degeneration, diabetic retinopathy, primary open-angle glaucoma, and other diseases.

Additionally, in order to reveal more information about bilberry bioactive compound property, researchers evaluated the effect of Ginkgo biloba extract (GBE) and anthocyanins on visual function in patients with normal tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage.

332 subjects data (209 men and 123 women) treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97) were reviewed.

According to the tested assays, the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months.


After anthocyanin treatment, the mean best-corrected visual acuity (BCVA) for all eyes improved from 0.16 logMAR units, and Humphrey Visual Field (HVF) mean deviation improved from -6.44.


Dr. Shim SH, the lead scientist said, "These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG".

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of eye diseases, pending to the validation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(2) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma by Shim SH1, Kim JM, Choi CY, Kim CY, Park KH. (PubMed)

3,3'-Diindolylmethane, the Best Anti-inflammatory Bioactive Compound

Inflammation is a natural response of the immune system which tries to protect our body by destroying the harmful pathogens before they cause damage.

In the acute phase of infection, the immune system white blood cells in the first line defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.

Overproduction of proinflammatory cytokines in some cases have been found to damage nearby healthy cells and tissues, causing the formation of scars.

In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal condition also switch to produce pro-inflammatory cytokines.

Most harmful pathogens are stopped at the acute phase of infection. However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.

Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.

Conventional treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.


3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

In the urgency of finding a potential compound which processes a strong anti-inflammatory activity, researchers examined the effects of 3,3'-Diindolylmethane (DIM), a condensation product of indole-3-carbinol, and a glucosinolate naturally occurring in Brassica genus vegetables.


The study carried out by differentiated the 3T3-L1 adipocytes in the co-cultured with RAW 264.7 macrophages and exposed to 20 µM, 40 µM and 60 µM DIM for 24 h followed by 100 nM insulin for 20 min.


According to the tested assays, DIM significantly (p<0.05) reduced the production and mRNA expression of proinflammatory cytokines (MCP-1, IL-6, and TNFα) in a concentration-dependent manner.

Injection of DIM was found to increase the expression of proteins involved in the positive regulation of metabolism and proliferation (IRS-1 pY612 and Akt-1/PKB pT308) through its anti-inflammatory properties.

In other words, DIM influences the glucose metabolic pathway by exerting an anti-inflammatory effect.

Dr.Lopez-Vazquez A, the lead scientist said, "The potential therapeutic benefits of DIM in the treatment of glucose metabolic disorders deserve further studies".

In order to reveal more information about DIM anti-inflammatory effects, researchers examined the dietary components found in cruciferous vegetables, on brain inflammation.

Administration of DIM suppressed lipopolysaccharide (LPS)-induced expression of reactive oxygen species and promoted the production of antioxidant enzymes in the host through inhibiting the microglial hyperactivation by attenuating inflammatory transcription factor NF-κB.

Furthermore, DIM protected primary cortical neurons from inflammatory toxicity induced by LPS.

In vivo model of neuroinflammation, DIM also suppressed LPS-induced brain inflammation in mouse hippocampus.

Based on the findings, Dr. Kim HW, the lead researchers said, "DIM may have beneficial potential against brain inflammation and neurodegenerative diseases through the negative regulation of the NF-κB signal pathway in microglia".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages by Lopez-Vazquez A1, Garcia-Banuelos JJ2, Gonzalez-Garibay AS1, Urzua-Lozano PE1, Del Toro-Arreola S1, Bueno-Topete MR1, Sanchez-Enriquez S3, Munoz-Valle JF4, Jave-Suarez LF5, Armendariz-Borunda J6, Bastidas-Ramirez BE. (PubMed)
(2) 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation by Kim HW1, Kim J, Kim J, Lee S, Choi BR, Han JS, Lee KW, Lee HJ. (PubMed)