Regular Walking Reduces Symptoms and Early Onset of Osteoarthritis(OA) in Population of 50Plus

Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but the regular walking contribution of health benefits of reduced risk of osteoarthritis in the younger and older elderly have been controversial.

Osteoarthritis (OA), a form of arthritis, is a condition or as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone. University of Porto Medical School indicated that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip and hand joints.

The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. The pain usually gets worse in a change of weather, at night and in the advanced diseases, the pain can occur even at rest(8). Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(10).

Moderate physical activity and walking programs had a positive effect on the quality of life of elderly individuals with knee OA, a new study suggested(5), through reduction of pain and improvement of physical function(6).

According to Dr. Evcik D and Dr. Sonel B., simple home-based exercise therapy and a regular walking program are effective in treating the symptoms of OA(7).

In older other with the preexisted condition of hip/knee OA, PA may reduce the risk of hip/knee OA, especially among women with no association between hip/knee OA and low joint stress(1).

In support to the effectiveness of physical exercise without increasing the risk of hip/knee OA and joint stress, Dr. Hootman JM and colleagues at the National Center for Chronic Disease Prevention and Health Promotion, said, "The joint stress PA score was not associated with an increased risk of hip/knee OA. Also, among walkers and runners, there was no association between the frequency, pace, or weekly training mileage and hip/knee OA"(2).


In fact, the 4316 people originally interviewed, 216 eligible cases (66 men, 150 women) were identified (mean age 57.1) insisted, there was little evidence to suggest that increased levels of regular physical activity throughout life lead to an increased risk of knee OA later in life(3) with exception to those of overweight(4).

Indeed, regular walking at one own pace is associated with a reduced risk of hip and knee osteoarthritis (OA)(8). Exercise and sport may probably be also a preventive tool against osteoarthritis, due to its positive effect on weight, muscle strength and possibly synovial inflammation(9).

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) The association between joint stress from physical activity and self-reported osteoarthritis: an analysis of the Cooper Clinic data by Rogers LQ1, Macera CA, Hootman JM, Ainsworth BE, Blairi SN.(PubMed)
(2) Influence of physical activity-related joint stress on the risk of self-reported hip/kneeosteoarthritis: a new method to quantify physical activity by Hootman JM1, Macera CA, Helmick CG, Blair SN.(PubMed)
(3) A case-control study to investigate the relation between low and moderate levels of physical activity and osteoarthritis of the knee using data collected as part of the Allied Dunbar National Fitness Survey by Sutton AJ1, Muir KR, Mockett S, Fentem P.(PubMed)
(4) A case-control study to investigate the relation between low and moderate levels of physical activity and osteoarthritis of the knee using data collected as part of the Allied Dunbar National Fitness Survey by Sutton AJ1, Muir KR, Mockett S, Fentem P.(PubMed)
(5) Impact of an exercise and walking protocol on quality of life for elderly people with OA of the knee by Dias RC1, Dias JM, Ramos LR.(PubMed)
(6) Exercise for osteoarthritis of the knee by Fransen M1, McConnell S, Harmer AR, Van der Esch M, Simic M, Bennell KL.(PubMed)
(7) Effectiveness of a home-based exercise therapy and walking program on osteoarthritis of the knee by Evcik D1, Sonel B.(PubMed)
(8) Exercise and osteoarthritis by David J Hunter1,2 and Felix Eckstein3,4(PMC)
(9) [Exercise--sports and osteoarthritis].[Article in French] by Ziltener JL1, Leal S, Borloz S.(PubMed)
(10) Most Common diseases of elder: The Clinical Trials and Studies of Osteoarthritis Back by Respectable Institutions by Kyle J. Norton

Phytochemical 3,3'-Diindolylmethane Kills Triple Negative Breast Cancer Cells in Vivo and Vitro

Unlike general breast cancer which processes either receptors for estrogen or progesterone and/or receptors with a protein called HER2, triple-negative breast cancer is a form of breast cancer that does not share the aforementioned characteristics.

In other words, triple-negative breast cancer does not have receptors of estrogen or progesterone or genetic preposition.

More importantly, triple negative breast cancer was found to infect women under the age of 40 and women of African or Asian ancestry in the US, compared to breast cancer in the White.

Particularly, according to the epidemiological study, younger women and in women of African ancestry are susceptible to a higher risk of basal-like triple negative breast cancers.

Compared to the malignant nature, triple-negative and basal-like breast cancers are highly invasive which can grow and spread quickly to other tissues and organs through lymph and blood.

Also compared to other breast cancer, with decreased risk after 5 years, triple-negative breast cancers have a substantial higher recurrent rate within 5 years after treatment.

Triple negative breast cancer shares the symptoms similar to those of breast cancer and risk factor except in the form of the genetic preposition.

According to Dr. Shimelis H, the lead scientist in the joint study led by the Mayo Clinic, said, "Pathogenic variants in BRIP1, RAD51C, and TP53 were associated with moderate risk (odds ratio > 2) of TNBC. Similar trends were observed for the African American population. Pathogenic variants in these TNBC genes were detected in 12.0% (3.7% non-BRCA1/2) of all participants".

And, "Multigene hereditary cancer panel testing can identify women with an elevated risk of TNBC due to mutations in BARD1, BRCA1, BRCA2, PALB2, and RAD51D".

In other words, if you carry the mutated genes BARD1, BRCA1, BRCA2, PALB2, and RAD51D, you are at a higher risk of triple negative breast cancer.

In seeking a potential compound for the treatment of breast cancer, researchers reexamined the promising anticancer effects of novel C-substituted diindolylmethane (DIM) derivatives DIM-10 and DIM-14 in aggressive triple negative breast cancer (TNBC, MDA-MB-231) models.

In vitro studies, novel C-substituted diindolylmethane (DIM) derivatives DIM-10 and DIM-14 demonstrated strong anticancer effects.

NLC formulations. including DIM-10 and DIM-14 extended significant increase in oral bioavailability compared to poor permeability and poor oral bioavailability of DIM-10 and DIM-14 used alone in pharmacokinetic studies.

Futhermore, compared to DIM-10, DIM-10 used alone, the NLC formulation showed an increase in Cmax and AUC values by 4.73 and 11.19-folds.

Similar increased anti-aggressive triple negative breast cancer (TNBC) efficacy was also found in the DIM-14 NLC formulations.

In dogs, the DIM-10 NLC formulations showed an increase of 2.65 and 2.94-fold in Cmax and AUC, against triple negative breast cancer (TNBC) respectively.

Moreover, DIM-10 or DIM-14 NLC formulations demonstrated significant a reduction in tumor volumes TNBC models and treated animals.

Dr. Godugu C, the lead scientist after taking into account co and confounders wrote, "NLC formulation of both DIM-10 and 14 is effective in TNBC models".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of triple negative breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer by Godugu C1, Doddapaneni R2, Safe SH3, Singh M. (PubMed)
(2) Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing by Shimelis H1, LaDuca H2, Hu C1, Hart SN3, Na J3, Thomas A3, Akinhanmi M1, Moore RM3, Brauch H4,5,6, Cox A7, Eccles DM8, Ewart-Toland A9, Fasching PA10,11,12, Fostira F13, Garber J14, Godwin AK15, Konstantopoulou I13, Nevanlinna H16, Sharma P15, Yannoukakos D13, Yao S17, Feng BJ18, Tippin Davis B2, Lilyquist J3, Pesaran T2, Goldgar DE18, Polley EC3, Dolinsky JS2, Couch. (PubMed)

Regular Walking Reduces Symptoms and Risk of Low Back Pain

Chronic back pain is a significant problem worldwide. According to statistic, Low back pain is a Musculoskeletal disorder (MSDs, affecting over 80% of the population in the US alone some points in their life. Chronic LBP (pain has persisted for longer than 3 months(5) prevalence in older adults was significantly higher than the 21-to-44-year age group

Regular physical activity has long been found to associate with the prevention of cancer, cardiovascular disease, and other chronic diseases, but regular walking contribution of health benefits of low back pain in the younger and older elderly have been lacking, probably due to body height and weight and other parameters(1), such as psychosocial factors(4).As available evidence on the association between physical activity (i.e. occupational load and non-occupational physical activities) and low back pain (LBP)(3).


But according to the review of the 2583 initially identified articles, 121 articles analyzed conducted by Fédération hospitals-Universitaire de médecine physique et de réadaptation Montpellier-Nîmes, suggested, " Moderate but regular physical activity( included walking) helps to improve fitness and does not increase the risk of acute pain in chronic LBP patients"(2).
In fact, in a systematic review of studies using pedometers, Dr. Mansi S and colleagues at the University of Otago said, ".....strong evidence for the effectiveness of pedometer walking interventions in increasing PA levels for patients with MSDs", using 11 electronic databases up to 20 February 2014(7).
In support of the effect of exercise, including walking the VA Ann Arbor Healthcare System insisted that exercise is an integral part of managing chronic back pain but to be effective requires that patients actively participate in the management process(6).


Does regular walking reduce risk of low back pain? the Cooper River Bridge Run Study said, "runners and walkers may have a lower relative risk for significant LBP" and " Prevalence of LBP at the time of survey completion was 13.6%"(9)in this population in comparison to the general statistic.

Indeed, walking 4 to 7 days per week is found to reduce the risk of LB disability onset by 50% to 80% on the older Black adults and 50% on older White adults(8), respectively.


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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Physical activity and low-back pain in schoolchildren by Skoffer B1, Foldspang A.(PubMed)
(2) Which physical activities and sports can be recommended to chronic low back pain patients after rehabilitation? by Ribaud A1, Tavares I, Viollet E, Julia M, Hérisson C, Dupeyron A.(PubMed)
(3) Physical activity and low back pain: a systematic review of recent literature by Heneweer H1, Staes F, Aufdemkampe G, van Rijn M, Vanhees L.(PubMed)
(4) Low back pain in schoolchildren: the role of mechanical and psychosocial factors by Watson KD1, Papageorgiou AC, Jones GT, Taylor S, Symmons DP, Silman AJ, Macfarlane GJ.(PubMed)
(5) Management of chronic low back pain by Nikolai Bogduk
(6) Veterans walk to beat back pain: study rationale, design and protocol of a randomized trial of a pedometer-based internet mediated intervention for patients with chronic low back pain by Krein SL1, Metreger T, Kadri R, Hughes M, Kerr EA, Piette JD, Kim HM, Richardson CR.(PubMed)
(7) A systematic review of studies using pedometers as an intervention for musculoskeletal diseases by Mansi S1, Milosavljevic S, Baxter GD, Tumilty S, Hendrick P.(PubMed)
(8) The effect of walking on lower body disability among older blacks and whites by Clark DO1.(PubMed)
(9) The Cooper River Bridge Run Study of low back pain in runners and walkers by Woolf SK1, Barfield WR, Nietert PJ, Mainous AG 3rd, Glaser JA.(PubMed)

Herbal Bilberry, A Natural Treatment for Peyronie's disease

Peyronie's disease is a rare condition caused by plaque, that forms inside the penis, leading to a bent erect penis, depending on where the plaque is located.

Patients with Peyronie's disease has been found to affect sexual desire due to a physical condition associated with painful sexual intercourse and erectile dysfunction.

Researchers do not know the exact causes of Peyronie's disease. However, according to the epidemiological studies, researchers suggested that injury that causes bleeding inside the penis may induce the built-up of scars, particularly in men with the genetic preposition of certain genes.

Most cases of pain in Peyronie’s disease are mild and often do not require treatment, however, over counter medicine may be needed occasionally.


Believe or not, most mild cases of men with Peyronie's disease do not require treatment as the condition has been found to go away within a year. In severe cases, surgery may be necessary to remove the scar tissues in the penis that cause the condition.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of Peyronie's disease investigated various antioxidants, including bilberry in PD treatment with significantly increase the likelihood of therapeutic success.

By comparing the effects of silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX) in patients with PD, researchers found that by administration of a single oral antioxidant; two oral antioxidants; three oral antioxidants; five oral antioxidants + local diclofenac; and five oral antioxidants + local diclofenac + PTX achieve better results when combining more than one agent.

According to the tested assays, the combination of more than a single compound reduced the symptoms in patients with PD, including the improvement and disappearance of penile pain; percentage of reduction in the volume of penile plaque; reduction in penile curvature; recovery of erectile function in patients with erectile dysfunction; increase in the International Index of Erectile Function score; and reduction of psychosexual impact.

Particularly, treatment of combined therapy including oral treatment with more than one antioxidant is greater when topical use of diclofenac gel and perilesional injection of PTX, compared to those of single conventional medicine.

In other words, combined natural or dietary antioxidants such as bilberry into the diet of patients with PD are more effective in inhibiting the symptoms compared to the use alone of any single ingredient therapy.

The final outcome of 6 months of treatment showed that combined antioxidant therapy is effective in treating PD.

Dr. Paulis G, the lead scientist, after taking other factors into account wrote in the final report, " Although several articles have already been published reporting the effectiveness of combined treatment in PD, this is the first study clearly proving how, as the number of substances used in treatment rises, a proportionally greater therapeutic effect is achieved."

Taken altogether, bilberry combined with other antioxidants or conventional medicines may be considered function remedies for the treatment of Peyronie's disease (PD), pending to the validation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Rationale of combination therapy with antioxidants in medical management of Peyronie's disease: results of clinical application by Paulis G1,2, Paulis A3, Romano G4, Barletta D5, Fabiani A. (PubMed)

Herbal Turmeric, A Natural And Potential Treatment of Chagas Heart Disease

Chagas disease (CD) is a medical condition caused by the protozoan parasite Trypanosoma cruzi.

According to the statistics, approximately 6 million people worldwide are living Chagas disease. The majority of patients reside in Mexico, Central America, and South America,

Chagas heart disease can be classified into
* Acute Chagas heart disease is characterized by the inflammation of the heart, gastrointestinal tract (mainly esophagus and colon), meninges, and central and peripheral nervous tissues. Untreated symptomatic patients in this phase may face a roughly 1% chance of death in the acute period, usually the result of severe myocarditis or meningoencephalitis


* The indeterminate form of Chagas heart disease is characterized by small foci of mild chronic myocarditis, with interstitial edema, early fibrosis, and infiltration by lymphocytes, macrophages, and plasma cells. Most patients with the indeterminate form will progress to the chronic form of Chagas heart disease such as dilated cardiomyopathy, at a rate of 1.85% to 7% annually.

* The chronic form of Chagas heart disease is characterized by cardiomegaly and increased cardiac mass, thinning of the ventricular walls, and aneurysmal lesions in various regions of the LV and right ventricle (RV).

Dr. Edimar Alcides Bocchi, the lead scientist in the treatment of Chagas heart disease wrote, "Pharmacological treatment and antiarrhythmic therapy for ChHD is mostly based on results for other etiologies. Heart transplantation is an established, valuable therapeutic option in refractory ChHD".

And, "Implantable cardioverter-defibrillators are indicated for the prevention of secondary sudden cardiac death. Specific etiological treatments should be revisited and reserved for select patients. Understanding and management of ChHD need improvement, including the development of randomized trials".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential compound for the treatment of Chagas heart disease, caused by the protozoan parasite Trypanosoma cruzi., researchers examined the anti-inflammatory and cardioprotective properties of curcumin (Cur).

The study included oral therapy with Cur on T. cruzi-mediated cardio-vasculopathy in acutely infected mice and in vitro, the response of parasite-infected human microvascular endothelial cells treated with this phytochemical.

According to the tested assays, oral Cur therapy showed a reduced inflammatory cell infiltration of myocardial arteries without lowering parasite levels in the tested infected mice.

Furthermore, mice treated with Cur showed significantly decreased vessel inflammation scores (p < 0.001), vascular permeabilities compared to mice treated with the phosphate-buffered saline-receiving group.

Moreover, levels of pro-inflammatory cytokines and ET-1 secretion involved in vascular constriction was also inhibited by the treatment of Cur.

Additionally, proteins and signaling pathways that promote the generation of inflammatory agents also inhibited by the injection of Cur.

In other words, curcumin (Cur) exerted the anti-inflammatory and cardioprotective properties against parasite-induced the onset of Chagas heart disease.

Based on the findings researchers wrote, "These findings identify new perspectives for exploring the potential of Cur-based interventions to ameliorate Chagas heart disease".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of Chagas heart disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-κ B signaling by Cai Y1, Li W1, Tu H1, Chen N1, Zhong Z1, Yan P1, Dong J. (PubMed)
(2) Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy by Hernández M1, Wicz S1, Santamaría MH2, Corral RS. (PubMed)
(3) Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management A Scientific Statement From the American Heart Association. (Circulation)
(4) Chronic Chagas Heart Disease Management
From Etiology to Cardiomyopathy Treatment by Edimar Alcides Bocchi, Reinaldo Bulgarelli Bestetti, Mauricio Ibrahim Scanavacca, Edecio Cunha Neto and Victor Sarli Issa. (JACC)

Regular Walking Reduces risk of Osteoporosis

Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but the regular walking contribution of health benefits of the younger elderly have not been explored.

Osteoporosis is defined as a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time. It is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries(1).

Regular walking has shown to reduce the prevalence of osteoporosis in older adult by keeping older people mobile and independent(2). According to the joint study led by Manchester Metropolitan University, osteoporosis and muscular weakness are decreased by regularly completing activities ranging from low-intensity walking(2).
The American College of Sports Medicine in the study of physical activity for older adults, suggested "(physical activity)improved bone health and, thus, reduction in risk for osteoporosis; improved postural stability, thereby reducing the risk of falling and associated injuries and fractures" and "The benefits associated with regular exercise and physical activity contribute to a more healthy, independent lifestyle, greatly improving the functional capacity and quality of life in this population"(3).

Dr. Buchner DM at the University of Washington School of Medicine said, "Epidemiologic evidence strongly supports a role of regular physical activity in successful aging by preserving muscle performance, promoting mobility, and reducing fall risk"(4).

In fact, exercisers with distance walked in six minutes, not only improved (p < .05) scores on an observational gait scale, Isokinetic strength in knee flexion(5), but also promoted suppression of bone turnover and reduced risk of osteoporosis, according to the study of 50 postmenopausal women, aged 49-75 years, with osteopenia/osteoporosis recruited: 32 women enter the exercise program (the exercise group) and 18 served as controls (the control group)(6).
Unfortunately, University Department of Primary Care and Population Sciences after intensive studying of brisk walking in the prevention of postmenopausal osteoporosis. insisted that brisk walking in the older adult, although reduces risk bone turn over, it is associated to risk of falling, according to the result of an investigation of 165 women drawn from the local accident and emergency departments with a history of fracture of an upper limb in the previous 2 years(7).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) GH and bone--experimental and clinical studies by Isaksson OG1, Ohlsson C, Bengtsson BA, Johannsson G.(PubMed)
(2) Physical activity in older age: perspectives for healthy ageing and frailty by McPhee JS1, French DP2, Jackson D3, Nazroo J4, Pendleton N5, Degens H6,7.(PubMed)
(3) American College of Sports Medicine Position Stand. Exercise and physical activity for older adults.[No authors listed](PubMed)
(4) Preserving mobility in older adults by Buchner DM1.(PubMed)
(5) Effects of a group exercise program on strength, mobility, and falls among fall-prone elderly men. by Rubenstein LZ1, Josephson KR, Trueblood PR, Loy S, Harker JO, Pietruszka FM, Robbins AS(PubMed)
(6) Effect of walking exercise on bone metabolism in postmenopausal women with osteopenia/osteoporosis by Yamazaki S1, Ichimura S, Iwamoto J, Takeda T, Toyama Y.(PubMed)
(7) Randomized placebo-controlled trial of brisk walking in the prevention of postmenopausal osteoporosis by Ebrahim S1, Thompson PW, Baskaran V, Evans K.(PubMed)

Phytochemical Lycopene Kills Head and Neck Cancer Cells, According to Study

Cancer is a group of disease caused by cell growth irregularly in the affected tissue caused by DNA alternation.

Head and neck cancer is a group of cancers originated from the mouth, nose, throat, larynx, sinuses, or salivary glands.

According to the statistics provided by the Canadian Cancer Society, approximately 4,300 Canadians are diagnosed with cancer of the head and neck every year. Head and neck cancer also cause the death of nearly 1,610 of Canadian.

The overall survival rate of 5 years after diagnosis is 62% tobacco use, alcohol consumption and viral infection including human papillomavirus (HPV) infection (for oropharyngeal cancer), and Epstein-Barr virus (EBV) infection (for nasopharyngeal cancer).
Some researchers suggested that diet pattern may have a strong impact on the onset of the disease.

Dr. Shu-Chun Chuang, the lead scientist wrote, "A dietary pattern score combining high fruit and vegetable intake and low red meat intake, was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random effects logistic regression model".

And, "Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR=0.90, 95% CI=0.84–0.97)".

In other words, if you are Western diet follower, you risk of head and neck cancer increased substantially compared to those who follow a traditional diet.

Most common symptoms of head and neck cancer are totally depending on the location of cancer including a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in the voice.

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

In the urgency to find a potential compound for the treatment of head and neck cancer, researchers examined the lycopene overload and cytotoxic effects on HNSCC cells.

According to the cell analysis, lycopene at a dose of >10 µM for >24 h inhibited the growth of FaDu and Cal27 cells in a time‑ and dose‑dependent manner.

Furthermore, injection of lycopene not only provided the clearest increase in growth inhibition by cell apoptosis but also limited the cancer cell invasive activity at a dose of 25 µM.

More precisely, lycopene killed cancer cell by exhibiting the protein associated with cell death programming and apoptosis.

Dr. Ye M, the lead scientist after taking other factors into account wrote, " lycopene induced the upregulation of the pro‑apoptotic protein, B‑cell lymphoma‑associated X protein".

Taken altogether, lycopene may be considered supplements for the prevention and treatment of head and neck cancer, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene inhibits the cell proliferation and invasion of human head and necksquamous cell carcinoma by Ye M1, Wu Q1, Zhang M1, Huang J. (PubMed)
(2) Levels of fat-soluble micronutrients and 2,6-cyclolycopene-1,5-diol in head and neck cancer patients by Djuric Z1, Ronis DL, Fowler KE, Ren J, Duffy SA. (PubMed)
(3) Diet and the Risk of Head and Neck Cancer: A Pooled Analysis in the INHANCE Consortium by
Shu-Chun Chuang,1,2 Mazda Jenab,2 Julia E. Heck,3 Cristina Bosetti,4 Renato Talamini,5Keitaro Matsuo,6 Xavier Castellsague,7 Silvia Franceschi,2 Rolando Herrero,8Deborah M. Winn,9 Carlo La Vecchia,4,10 Hal Morgenstern,11 Zuo-Feng Zhang,3 Fabio Levi,12Luigino Dal Maso,5 Karl Kelsey,13 Michael D. McClean,14 Thomas Vaughan,15Philip Lazarus,16 Joshua Muscat,16 Heribert Ramroth,17 Chu Chen,15 Stephen M. Schwartz,15Jose Eluf-Neto,18 Richard B. Hayes,19 Mark Purdue,9 Stefania Boccia,20,21 Gabriella Cadoni,22David Zaridze,23 Sergio Koifman,24 Maria Paula Curado,2 Wolfgang Ahrens,25Simone Benhamou,26 Elena Matos,27 Pagona Lagiou,28 Neonilla Szeszenia-Dabrowska,29Andrew F. Olshan,30 Leticia Fernandez,31 Ana Menezes,32 Antonio Agudo,33Alexander W. Daudt,34 Franco Merletti,35 Gary J. Macfarlane,36 Kristina Kjaerheim,37Dana Mates,38 Ivana Holcatova,39 Stimson Schantz,40 Guo-Pei Yu,40 Lorenzo Simonato,41Hermann Brenner,42 Heiko Mueller,42 David I. Conway,43 Peter Thomson,44Eleonora Fabianova,45 Ariana Znaor,46 Peter Rudnai,47 Claire M. Healy,48 Gilles Ferro,2Paul Brennan,2 Paolo Boffetta,49,50 and Mia Hashibe. (PMC)