Regular physical activity has long been found to associate with the prevention of cancer, cardiovascular disease, and other chronic diseases, the joint study led by Universidade Federal de Minas Gerais, showed that regular physical activity (PA) induces desirable changes in plasma levels of high- and low-density lipoproteins (HDL and LDL, respectively) and triglycerides (TG), important risk factors for cardiometabolic diseases(4).
But the regular walking contribution of reduced risk of high triglyceride level in the younger and older elderly have been lacking, probably due to the effectiveness of modern diet restriction(2)(3) in syndrome controlling.
High Levels of Triglyceride is a condition of high levels of fat found in the blood. The University of South Carolina study blood lipid and lipoprotein adaptations to exercise suggested, exercise, including brisk walking or jogging, induced energy expenditure is also associated with TC and LDL-C reductions(1).
Regular walking showed to benefit a reduction of body fat stores, endogenous insulin requirements, and food intake and improved the ability to eliminate cholesterol and triglyceride concentrations by increasing the plasma high-density lipoprotein fraction(6).
Dr. Durstine JL and colleagues at the University of South Carolina, said, "Plasma triglycerides reductions are often observed after exercise training regimens requiring energy expenditure" but the health issues would fair better with "a comprehensive medical management plan that optimizes pharmacologic, reduced dietary fat intake, weight loss, and exercise interventions"(5).
Cardiovascular disease, a complication of high blood cholesterol and triglyceride kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease, according to statistic and literature, hyperlipidemia is a good document risk factor for Cardiovascular Disease(7).
Regular Walking also is found to Reduces Risk of Complication of Heart Disease in patients high triglyceride level. A study of 14 obese middle-aged women, after 24 weeks in the exercise program, exhibited a significant reduction of weight, body fat, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, and triglycerides, whereas HDLC, a metabolic improvement factor, increased significantly(8).
Stanford University School of Medicine study of one hundred nineteen of the men and 112 of the women showed that regular exercise in overweight men and women is the best way to enhance the improvement in plasma lipoprotein levels, together with the adoption of a low-saturated-fat, low-cholesterol diet(9).
In support the effectiveness of regular walking in reduced levels of cholesterol and triglycerides, the study of a 10-week Nordic walking training program on the level of GH and LH in elderly women, insisted, regular walking significantly decrease total cholesterol, LDL cholesterol and triglycerides (all on a similar average by between 0.1 and 0.2%), creatine kinase (on average by 14%), lactate dehydrogenase (on average by 4%), C-reactive protein (on average by 24%), and body mass (on average by 5.7%) of that protect against menopause-related catabolic processes(10).
Taking all together, regular walking when used in conjunction with low-saturated-fat, low-cholesterol diet may promote a better result in a reduced level of triglycerides, and total cholesterol in compared with the baseline of all testing subjects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. by Durstine JL1, Grandjean PW, Davis PG, Ferguson MA, Alderson NL, DuBose KD(PubMed)
(2) [Effects of intrauterine growth restriction and high-fat diet on serum lipid and transcriptional levels of related hepatic genes in rats].[Article in Chinese] by Chen LH1, Liang L, Zhu WF, Wang YM, Zhu JF.(PubMed)
(3) Dietary Interventions and Changes in Cardio-Metabolic Parameters in Metabolically Healthy Obese Subjects: A Systematic Review with Meta-Analysis by Stelmach-Mardas M1,2, Walkowiak J3.(PubMed)
(4) Physical Activity and Lipid Profile in the ELSA- Brasil Study.[Article in English, Portuguese] by Silva RC1, Diniz MF1, Alvim S2, Vidigal PG1, Fedeli LM3, Barreto SM1.(PubMed)
(5) Lipids, lipoproteins, and exercise by Durstine JL1, Grandjean PW, Cox CA, Thompson PD.(PubMed)
(6) Effects of a vigorous walking program on body composition, and carbohydrate and lipid metabolism of obese young men by Leon AS, Conrad J, Hunninghake DB, Serfass R.(PubMed)
(7) Hyperlipidemia as a Risk Factor for Cardiovascular Disease by Robert H. Nelson, MDa,b,(PMC)
(8) Effect of Walking Exercise on Changes in Cardiorespiratory Fitness, Metabolic Syndrome Markers, and High-molecular-weight Adiponectin in Obese Middle-aged Women by Kim DY1, Seo BD2, Kim DJ1.(PubMed)
(9) The effects on plasma lipoproteins of a prudent weight-reducing diet, with or without exercise, in overweight men and women by Wood PD1, Stefanick ML, Williams PT, Haskell WL.(PubMed)
(10) The effect of a 10-week Nordic walking training program on the level of GH and LH in elderly women by Hagner-Derengowska M1, Kałużny K2, Hagner W2, Plaskiewicz A2, Bronisz A3, Borkowska A1, Budzyński J4.(PubMed)
Tuesday, June 11, 2019
Tomatoes Normalize the Blood Glucose Against Hyperglycemia on Diabetes
Hyperglycemia found in patients with diabetes is a condition of abnormally high blood glucose in the bloodstream.
Most cases of hyperglycemia is a result of poor diabetic control including unhealthy food and physical activity choices, medical conditions, nondiabetes medications, particularly in people who frequent skipping or not taking enough glucose-lowering medication.
* Foot Complications are the condition caused by nerves damage that controls the leg, leading to numbness and severe pain in the feet. in the blood but also can cause kidney failure.
* Kidney disease is a condition that can reduce the function of the kidney in filtering the waste in the blood.
* Hypertension is a condition of high blood pressure that can lead to an increase in the risk heart attack, stroke, eye problems.
* Stroke caused by abnormally high blood pressure and high blood glucose.
* Gastroparesis is a condition caused by the reduced function of vagus nerves that control the movement of food.
Some researchers suggested by the change of lifestyle and moderate exercise accompanied by taking your medicine daily, hyperglycemia is preventable in diabetes.
The Mayo Clinic Staff in the article " Diabetes management: How lifestyle, daily routine affect blood sugar", wrote "Healthy eating is a cornerstone of healthy living — with or without diabetes. But if you have diabetes, you need to know how foods affect your blood sugar levels".
"Physical activity is another important part of your diabetes management plan. When you exercise, your muscles use sugar (glucose) for energy. Regular physical activity also helps your body use insulin more efficiently".
And, "Insulin and other diabetes medications are designed to lower your blood sugar levels when diet and exercise alone aren't sufficient for managing diabetes. But the effectiveness of these medications depends on the timing and size of the dose. Medications you take for conditions other than diabetes also can affect your blood sugar levels".
In other words, by following a healthy lifestyle including diet, moderate exercise, taking the required medicines hyperglycemia is controllable.
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound or whole food for the treatment of hyperglycemia, researchers examined the relationship between hyperglycemia and both serum carotenoids and intake of vegetables and fruits.
The study induced 133 subjects with a history of diabetes mellitus or hyperglycemia diagnosed using a 5.6% cutoff value for hemoglobin A1c (High HbA1c group, n = 151) recruited from among inhabitants of a rural area in Hokkaido, Japan.
High HbA1c between 5.7% and 6.4% is an indication of a higher risk of diabetes.
According to the returned of a questionnaire administered by public health nurses on the Intake frequencies of vegetables and fruits,* The odds ratio (OR) for high HbA1c was 0.49 on high intake frequency of carrot and pumpkin and the OR for DM was 1.21 (95% Cl: 0.79-1.84)
* There are no significant relationships between high HbA1c and intake frequencies of other vegetables and fruits.
* The ORs on high serum levels of alpha- and beta-carotenes, lycopene, beta-cryptoxanthin and zeaxanthin and lutein were 0.38 (0.22-0.65), 0.35 (0.21-0.59), 0.57 (0.35-0.93), 0.35 (0.20-0.59), and 0.88 (0.54-1.46) for high HbA1c, respectively.
In other words, tomatoes may have a strong effect against the onset of hyperglycemia by normalizing the levels of HbA1c.
Based on the finding, researchers said, "Intake of vegetables and fruits rich in carotenoids might be a protective factor against hyperglycemia".
Taken altogether, tomatoes may be considered functional foods for the prevention and treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Relationship between serum carotenoids and hyperglycemia: a population-based cross-sectional study by Suzuki K1, Ito Y, Nakamura S, Ochiai J, Aoki K. (PubMed)
(2) Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer's Disease by Li R1, Zhang Y1, Rasool S1, Geetha T1, Babu JR. (PubMed)
Most cases of hyperglycemia is a result of poor diabetic control including unhealthy food and physical activity choices, medical conditions, nondiabetes medications, particularly in people who frequent skipping or not taking enough glucose-lowering medication.
* Foot Complications are the condition caused by nerves damage that controls the leg, leading to numbness and severe pain in the feet. in the blood but also can cause kidney failure.
* Kidney disease is a condition that can reduce the function of the kidney in filtering the waste in the blood.
* Hypertension is a condition of high blood pressure that can lead to an increase in the risk heart attack, stroke, eye problems.
* Stroke caused by abnormally high blood pressure and high blood glucose.
* Gastroparesis is a condition caused by the reduced function of vagus nerves that control the movement of food.
Some researchers suggested by the change of lifestyle and moderate exercise accompanied by taking your medicine daily, hyperglycemia is preventable in diabetes.
The Mayo Clinic Staff in the article " Diabetes management: How lifestyle, daily routine affect blood sugar", wrote "Healthy eating is a cornerstone of healthy living — with or without diabetes. But if you have diabetes, you need to know how foods affect your blood sugar levels".
"Physical activity is another important part of your diabetes management plan. When you exercise, your muscles use sugar (glucose) for energy. Regular physical activity also helps your body use insulin more efficiently".
And, "Insulin and other diabetes medications are designed to lower your blood sugar levels when diet and exercise alone aren't sufficient for managing diabetes. But the effectiveness of these medications depends on the timing and size of the dose. Medications you take for conditions other than diabetes also can affect your blood sugar levels".
In other words, by following a healthy lifestyle including diet, moderate exercise, taking the required medicines hyperglycemia is controllable.
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound or whole food for the treatment of hyperglycemia, researchers examined the relationship between hyperglycemia and both serum carotenoids and intake of vegetables and fruits.
The study induced 133 subjects with a history of diabetes mellitus or hyperglycemia diagnosed using a 5.6% cutoff value for hemoglobin A1c (High HbA1c group, n = 151) recruited from among inhabitants of a rural area in Hokkaido, Japan.
High HbA1c between 5.7% and 6.4% is an indication of a higher risk of diabetes.
According to the returned of a questionnaire administered by public health nurses on the Intake frequencies of vegetables and fruits,* The odds ratio (OR) for high HbA1c was 0.49 on high intake frequency of carrot and pumpkin and the OR for DM was 1.21 (95% Cl: 0.79-1.84)
* There are no significant relationships between high HbA1c and intake frequencies of other vegetables and fruits.
* The ORs on high serum levels of alpha- and beta-carotenes, lycopene, beta-cryptoxanthin and zeaxanthin and lutein were 0.38 (0.22-0.65), 0.35 (0.21-0.59), 0.57 (0.35-0.93), 0.35 (0.20-0.59), and 0.88 (0.54-1.46) for high HbA1c, respectively.
In other words, tomatoes may have a strong effect against the onset of hyperglycemia by normalizing the levels of HbA1c.
Based on the finding, researchers said, "Intake of vegetables and fruits rich in carotenoids might be a protective factor against hyperglycemia".
Taken altogether, tomatoes may be considered functional foods for the prevention and treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Relationship between serum carotenoids and hyperglycemia: a population-based cross-sectional study by Suzuki K1, Ito Y, Nakamura S, Ochiai J, Aoki K. (PubMed)
(2) Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer's Disease by Li R1, Zhang Y1, Rasool S1, Geetha T1, Babu JR. (PubMed)
Monday, June 10, 2019
Bioactive Ingredient Alliin Protects the Heart Against Cardiomyocyte Hypertrophy
Cardiomyocyte hypertrophy is a medical condition of thickening of the heart muscle, leading to reduced function of the heart in pumping blood throughout the body.
The heart muscles made up the bulk of the heart’s mass control the heartbeat with high contractile strength and endurance.
Cardiac muscle also has a unique function to regulate the heart performance by spreading electrochemical signals all cells in the heart.
Damage of heart muscle has bee found to induce blood vessel diseases, such as coronary artery disease; heart rhythm problems (arrhythmias).
In some cases, head muscles associated disease also are found in patients with congenital heart defects.
Symptoms of include breathlessness with exertion or at rest, legs, ankles, and feet swelling. persistent fatigue, dizziness, lightheadedness, and fainting, particularly, in the symptoms of irregular heartbeats.
Conventionally, treatment of diseases associated with cardiomyocyte hypertrophy depending on the types of heart disease, including lowering blood pressure medication such as ACE inhibitors; lowing the heart rate, such as beta blockers, normalizing heart beating and balancing electrolytes in the body.
Making a healthy lifestyle change and moderate exercise may also recommend by your doctor.
Out of many risk factors associated with the onset of cardiomyocyte hypertrophy, smoking can be considered one of the major prevalent factor.
Dr. Moustafa Al Hariri,, the lead scientist wrote, "Cardiovascular diseases are the leading causes of morbidity and mortality worldwide. Cigarette smoking remains a global health epidemic with associated detrimental effects on the cardiovascular system".
And, "(According to the results of the study) cigarette smoking exposure is associated with significant cardiovascular pathology such as cardiac hypertrophy, inflammation, pro-fibrotic, and atherogenic markers and aortic calcification in an animal model as assessed 1-month post exposure".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In the urgency to discover a natural compound for the treatment of heart disease, researchers examined alliin, the main constituent found in garlic in the prevention of cardiomyocyte hypertrophy and cell death.
The study included adult rat cardiomyocytes induce hypertrophy by Norepinephrine (NE) was pretreated with garlic skin and flesh extracts.
Before treatment of garlic skin and flesh extracts, exposure of cardiomyocytes to NE induced an increase in cell size and cell death, an indication of cardiomyocyte hypertrophy.
This increase of cardiomyocyte hypertrophy and cell death was prevented significantly upon treatment with garlic skin and flesh extracts.
Furthermore, the increased cells apoptosis and oxidative stress in cardiomyocytes by norepinephrine were also inhibited by the presence of the extract.
In the constituent analysis, the efficacy of anti cardiomyocyte hypertrophy and cell death may be attributed to the concentration of allicin and alliin.
In order to reveal more information about the alliin anti cardiomyocyte hypertrophy, the team from the SASTRA-Deemed University investigated the preventive effect of S-allyl cysteine sulfoxide (SACS) in isoproterenol (ISO)-induced myocardial ischemia in male Wistar rats.
The selected rat was were pretreated with SACS (40 and 80 mg kg(-1) body-weight) for 5 weeks. After the treatment period, followed by the ISO (150 mg kg(-1) body-weight) administered subcutaneously at intervals of 24 h for 2 days.
According to the tested assays, oral pretreatment with SACS significantly decreased the activity of HMG CoA reductase associated with the production of cholesterol and other isoprenoids and significantly increased the activity of LCAT involved converting free cholesterol into cholesteryl ester in ISO-induced rats.
Futhermore, pretreatment with SACS significantly decreased the levels of lipid peroxides in ISO-treated rats.
In concentration perspective, at a dose of 80 mg kg(-1) body-weight was more effective in normalizing all the biochemical parameters compared to the dose of 40 mg kg(-1) body-weight.
In other words, alliin inhibited the onset of myocardial ischemia caused by isoproterenol (ISO) in a doses dependent manner, in vitro and vivo.
Taken altogether, alliin may be considered supplements for the prevention and treatment of cardiomyocyte hypertrophy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide by Louis XL1, Murphy R, Thandapilly SJ, Yu L, Netticadan T. (PubMed)
(2) Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury by Sangeetha T1, Darlin Quine S. (PubMed)
(3) Cigarette Smoking-Induced Cardiac Hypertrophy, Vascular Inflammation and Injury Are Attenuated by Antioxidant Supplementation in an Animal Model by Moustafa Al Hariri,1,† Kazem Zibara,2,3,† Wissam Farhat,2,† Yasmine Hashem,4Nadia Soudani,4,5 Farah Al Ibrahim,3 Eva Hamade,2,3 Asad Zeidan,4 Ahmad Husari,6,* andFiras Kobeissy. (PMC)
The heart muscles made up the bulk of the heart’s mass control the heartbeat with high contractile strength and endurance.
Cardiac muscle also has a unique function to regulate the heart performance by spreading electrochemical signals all cells in the heart.
Damage of heart muscle has bee found to induce blood vessel diseases, such as coronary artery disease; heart rhythm problems (arrhythmias).
In some cases, head muscles associated disease also are found in patients with congenital heart defects.
Symptoms of include breathlessness with exertion or at rest, legs, ankles, and feet swelling. persistent fatigue, dizziness, lightheadedness, and fainting, particularly, in the symptoms of irregular heartbeats.
Conventionally, treatment of diseases associated with cardiomyocyte hypertrophy depending on the types of heart disease, including lowering blood pressure medication such as ACE inhibitors; lowing the heart rate, such as beta blockers, normalizing heart beating and balancing electrolytes in the body.
Making a healthy lifestyle change and moderate exercise may also recommend by your doctor.
Out of many risk factors associated with the onset of cardiomyocyte hypertrophy, smoking can be considered one of the major prevalent factor.
Dr. Moustafa Al Hariri,, the lead scientist wrote, "Cardiovascular diseases are the leading causes of morbidity and mortality worldwide. Cigarette smoking remains a global health epidemic with associated detrimental effects on the cardiovascular system".
And, "(According to the results of the study) cigarette smoking exposure is associated with significant cardiovascular pathology such as cardiac hypertrophy, inflammation, pro-fibrotic, and atherogenic markers and aortic calcification in an animal model as assessed 1-month post exposure".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In the urgency to discover a natural compound for the treatment of heart disease, researchers examined alliin, the main constituent found in garlic in the prevention of cardiomyocyte hypertrophy and cell death.
The study included adult rat cardiomyocytes induce hypertrophy by Norepinephrine (NE) was pretreated with garlic skin and flesh extracts.
Before treatment of garlic skin and flesh extracts, exposure of cardiomyocytes to NE induced an increase in cell size and cell death, an indication of cardiomyocyte hypertrophy.
This increase of cardiomyocyte hypertrophy and cell death was prevented significantly upon treatment with garlic skin and flesh extracts.
Furthermore, the increased cells apoptosis and oxidative stress in cardiomyocytes by norepinephrine were also inhibited by the presence of the extract.
In the constituent analysis, the efficacy of anti cardiomyocyte hypertrophy and cell death may be attributed to the concentration of allicin and alliin.
In order to reveal more information about the alliin anti cardiomyocyte hypertrophy, the team from the SASTRA-Deemed University investigated the preventive effect of S-allyl cysteine sulfoxide (SACS) in isoproterenol (ISO)-induced myocardial ischemia in male Wistar rats.
The selected rat was were pretreated with SACS (40 and 80 mg kg(-1) body-weight) for 5 weeks. After the treatment period, followed by the ISO (150 mg kg(-1) body-weight) administered subcutaneously at intervals of 24 h for 2 days.
According to the tested assays, oral pretreatment with SACS significantly decreased the activity of HMG CoA reductase associated with the production of cholesterol and other isoprenoids and significantly increased the activity of LCAT involved converting free cholesterol into cholesteryl ester in ISO-induced rats.
Futhermore, pretreatment with SACS significantly decreased the levels of lipid peroxides in ISO-treated rats.
In concentration perspective, at a dose of 80 mg kg(-1) body-weight was more effective in normalizing all the biochemical parameters compared to the dose of 40 mg kg(-1) body-weight.
In other words, alliin inhibited the onset of myocardial ischemia caused by isoproterenol (ISO) in a doses dependent manner, in vitro and vivo.
Taken altogether, alliin may be considered supplements for the prevention and treatment of cardiomyocyte hypertrophy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide by Louis XL1, Murphy R, Thandapilly SJ, Yu L, Netticadan T. (PubMed)
(2) Preventive effect of S-allyl cysteine sulfoxide (alliin) on cardiac marker enzymes and lipids in isoproterenol-induced myocardial injury by Sangeetha T1, Darlin Quine S. (PubMed)
(3) Cigarette Smoking-Induced Cardiac Hypertrophy, Vascular Inflammation and Injury Are Attenuated by Antioxidant Supplementation in an Animal Model by Moustafa Al Hariri,1,† Kazem Zibara,2,3,† Wissam Farhat,2,† Yasmine Hashem,4Nadia Soudani,4,5 Farah Al Ibrahim,3 Eva Hamade,2,3 Asad Zeidan,4 Ahmad Husari,6,* andFiras Kobeissy. (PMC)
Regular Walking Reduces Symptoms and Risk of Gout
Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but regular walking contribution of health benefits of reduced symptoms of Gout in the younger and older elderly have been lacking, due to caregivers and physicians prefer to emphasize, in most cases in reduced intake of foods with rich of purines(4).
A Delphi exercise conducted by the University of Otago suggested that both physicians and patients agreed upon several key features of gout, including severity, functional results, and idiographic perception and patterns of symptoms(1).
Dr. Stewart S and colleagues at the joint study led by the Auckland University of Technology indicated the importance of footwear worn as walking shoes with good footwear characteristics can influence plantar pressure values and encourage a more efficient heel to toe gait pattern in people with gout(2)
The National Kidney foundation reminds "some people with gout do not have high uric acid levels, so it is very important to maintain a healthy lifestyle no matter the level. Do not smoke, follow a well-balanced diet, maintain a healthy weight, and exercise"(5).
In fact, according to 2008 American Society for Clinical Nutrition, the risk of gout is lower in men who are more physically active, maintain ideal body weight, and consume diets enriched in fruit and limited in meat and alcohol(3). Unfortunately, exercise, including walking during a gout attack will worsen the condition by inducing more pain and lengthening the inflammation.
“Exercises to relieve gout should be done steady and cautiously as to avoid further irritation to the joints. The best exercises for gout are a range of motion types: strength training, stretching and building endurance. Yoga is an exercise that incorporates all four; however, there are other exercises that can be done individually also” According to the article of How to Exercise If You Have Gout(6).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A delphi exercise to identify characteristic features of gout - opinions from patients and physicians, the first stage in developing new classification criteria by Prowse RL1, Dalbeth N, Kavanaugh A, Adebajo AO, Gaffo AL, Terkeltaub R, Mandell BF, Suryana BP, Goldenstein-Schainberg C, Diaz-Torne C, Khanna D, Lioté F, Mccarthy G, Kerr GS, Yamanaka H, Janssens H, Baraf HF, Chen JH, Vazquez-Mellado J, Harrold LR, Stamp LK, Van De Laar MA, Janssen M, Doherty M, Boers M, Edwards NL, Gow P, Chapman P, Khanna P, Helliwell PS, Grainger R,Schumacher HR, Neogi T, Jansen TL, Louthrenoo W, Sivera F, Taylor WJ, Alten R.(PubMed)
(2) The effect of good and poor walking shoe characteristics on plantar pressure and gait in people with gout by Stewart S1, Dalbeth N2, McNair P3, Parmar P4, Gow P5, Rome K3.(PubMed)
(3) Effects of diet, physical activity and performance, and body weight on incident gout in ostensibly healthy, vigorously active men1,2,3 by Paul T Williams(American Society for Clinical Nutrition)
(4)A case-control study of the association of diet and obesity with gout in Taiwan1,2,3 by Li-Ching Lyu, Chi-Yin Hsu, Ching-Ying Yeh, Meei-Shyuan Lee, Su-Hua Huang, and Ching-Lan Chen(American Society for Clinical Nutrition)
(5) GOUT AND HYPERURICEMIA(The national Kidney foundation)
(6) How to Exercise If You Have Gout(3fc)
A Delphi exercise conducted by the University of Otago suggested that both physicians and patients agreed upon several key features of gout, including severity, functional results, and idiographic perception and patterns of symptoms(1).
Dr. Stewart S and colleagues at the joint study led by the Auckland University of Technology indicated the importance of footwear worn as walking shoes with good footwear characteristics can influence plantar pressure values and encourage a more efficient heel to toe gait pattern in people with gout(2)
The National Kidney foundation reminds "some people with gout do not have high uric acid levels, so it is very important to maintain a healthy lifestyle no matter the level. Do not smoke, follow a well-balanced diet, maintain a healthy weight, and exercise"(5).
In fact, according to 2008 American Society for Clinical Nutrition, the risk of gout is lower in men who are more physically active, maintain ideal body weight, and consume diets enriched in fruit and limited in meat and alcohol(3). Unfortunately, exercise, including walking during a gout attack will worsen the condition by inducing more pain and lengthening the inflammation.
“Exercises to relieve gout should be done steady and cautiously as to avoid further irritation to the joints. The best exercises for gout are a range of motion types: strength training, stretching and building endurance. Yoga is an exercise that incorporates all four; however, there are other exercises that can be done individually also” According to the article of How to Exercise If You Have Gout(6).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A delphi exercise to identify characteristic features of gout - opinions from patients and physicians, the first stage in developing new classification criteria by Prowse RL1, Dalbeth N, Kavanaugh A, Adebajo AO, Gaffo AL, Terkeltaub R, Mandell BF, Suryana BP, Goldenstein-Schainberg C, Diaz-Torne C, Khanna D, Lioté F, Mccarthy G, Kerr GS, Yamanaka H, Janssens H, Baraf HF, Chen JH, Vazquez-Mellado J, Harrold LR, Stamp LK, Van De Laar MA, Janssen M, Doherty M, Boers M, Edwards NL, Gow P, Chapman P, Khanna P, Helliwell PS, Grainger R,Schumacher HR, Neogi T, Jansen TL, Louthrenoo W, Sivera F, Taylor WJ, Alten R.(PubMed)
(2) The effect of good and poor walking shoe characteristics on plantar pressure and gait in people with gout by Stewart S1, Dalbeth N2, McNair P3, Parmar P4, Gow P5, Rome K3.(PubMed)
(3) Effects of diet, physical activity and performance, and body weight on incident gout in ostensibly healthy, vigorously active men1,2,3 by Paul T Williams(American Society for Clinical Nutrition)
(4)A case-control study of the association of diet and obesity with gout in Taiwan1,2,3 by Li-Ching Lyu, Chi-Yin Hsu, Ching-Ying Yeh, Meei-Shyuan Lee, Su-Hua Huang, and Ching-Lan Chen(American Society for Clinical Nutrition)
(5) GOUT AND HYPERURICEMIA(The national Kidney foundation)
(6) How to Exercise If You Have Gout(3fc)
Sunday, June 9, 2019
The 46 Amazing Health Benefits of Fennel, According to Medical Literature
Fennel is a species of Foeniculum Vulgare, belonging to the family Apiaceae (Umbelliferae), native to the shores of the Mediterranean. It is now widely cultivated all around the globe to use as food and herb.
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
Chemical constituents
1. 1,3-benzenediol
2. 1-methoxycyclohexene
3. O-cymene
4. Sorbic acid,
5. 2-hydroxy-3-methyl-2-cyclopenten-1-one
6. Estragole
7. Limonene-10-ol
8. 3-methyl-2-cyclopenten-1-one
9. Linoleic acid
10. Oleic acid
11. Undecanal
12. 2,4-undecadienal
13. trans-Anethole
14. Fenchone
15. Limonene
1. Infectious Diseases: The Natural Antibiotics Alternative With No Side Effects
2. Food therapy - Fennel as antioxidants
3. Food Therapy: Fennel In Attenuated Risk, Progression and Treatment of Irritable Bowel Syndrome
4. Food Therapy: Fennel and it's Bioactive Anethole in Attenuated Risk, Progression and Treatment of Periodontitis (PD)
5. Food Therapy: Fennel or Its Composition as Laxative Agent for Treatment of Chronic Constipation
6. Food Therapy: Fennel In Attenuated Risk, Progression and Treatment of Intestinal Dysbiosis
7. Food Therapy: Fennel In Ameliorated Risk, Progression and Treatment of Breast Cancer
8. Herbal Therapy: Fennel, A Potent Functional Food for Treatment of Infantile Colic
9. Herbal Therapy: The Best of Perennially Herbal.Fennel In Ameliorated Risk, Progression and Treatment of Prostate cancer
10. Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period
11. Food Therapy; Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period
12. Herbal Therapy: Fennel In Reduced Symptoms and Treatment of Estrogenic Deficiency Related Diseases
13. Eat Fennel to Inhibit Daily Stress in the Workplaces, Scientists Suggested
14. Women’s Health: Protect DNA Integrity Against Breast Cancer with This Single Herb, Online Medical Literature Revealed
15. Food Therapy: Intake Fennel to Optimize the Digestive Functioning in absorbed Nutrients and Fluids
16. Food Therapy: Fennel The Potent Food With Cytoprotection and Antitumor Activity
17. Food Therapy: Fennel and Its Extracts in Detoxed Body Toxins, According to PubMed Online Literature
18. Herbal Therapy: Fennel, A Potent Chemo-Preventive and Modulatory Functional Herb
19. Fennel May Improve Your Heart Functioning Naturally and Permanently, Studies Showed
20. How to Treat Painful Primary Dysmenorrhea Quickly and Permanently, According to PubMed
21. 325. Fennel Seed Extracts That Gobble Up Toxins Caused by Drug Interaction and Toxicity, Scientists Show
22. Fennel, The Best Herbal Remedy Which Detoxes Your Kidneys Through Promoting Excess Fluids Secretion, Public Medical Library Reveal
23. Fennel, The Herbal Remedy Which Protects Our Body Against The Onset of Acute Inflammation and Chronic Inflammatory Diseases, Scientists Find
34. Fennel, A Potent Neurons Protective and Memory Enhancing Functional Herb
35. Fennel, The Reliable and Less Expensive Functional Food For Treatment of Hirsutism
36. Detoxification: Fennel, The Potent and Functional Food Which Protects the Liver Against Toxicity
37. Fennel, The Functional Herb Which Processes Anti Anxiolytic Property Similar to Those of Diazepam with No Adverse Effects, Scientists Find
38. Fennel, The Natural Remedy Which Protects the Brain Neurons Against The Onset of Cognitive Impairment, Scientists Suggest
39. Fennel, the Functional Herb Which Processes Anti-antispasmodic Activity, Scientists Find
40. Fennel, the Best Functional Food Which Processes Anti Hypolipidemic Activity
41. Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find
42. Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find
43. Fennel, a Natural Anti Fever Functional Food
44. Fennel, The Natural Free Radical Scavenger, Scientists Find
45. Fennel Essential Oil and Extract, The Potent Anti Hypoglycemic Remedies, Scientists Reveal
46. Fennel, the Function Food Which Balances the Ratio of the Levels Free Radicals and Antioxidants in Our Body
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
Chemical constituents
1. 1,3-benzenediol
2. 1-methoxycyclohexene
3. O-cymene
4. Sorbic acid,
5. 2-hydroxy-3-methyl-2-cyclopenten-1-one
6. Estragole
7. Limonene-10-ol
8. 3-methyl-2-cyclopenten-1-one
9. Linoleic acid
10. Oleic acid
11. Undecanal
12. 2,4-undecadienal
13. trans-Anethole
14. Fenchone
15. Limonene
1. Infectious Diseases: The Natural Antibiotics Alternative With No Side Effects
2. Food therapy - Fennel as antioxidants
3. Food Therapy: Fennel In Attenuated Risk, Progression and Treatment of Irritable Bowel Syndrome
4. Food Therapy: Fennel and it's Bioactive Anethole in Attenuated Risk, Progression and Treatment of Periodontitis (PD)
5. Food Therapy: Fennel or Its Composition as Laxative Agent for Treatment of Chronic Constipation
6. Food Therapy: Fennel In Attenuated Risk, Progression and Treatment of Intestinal Dysbiosis
7. Food Therapy: Fennel In Ameliorated Risk, Progression and Treatment of Breast Cancer
8. Herbal Therapy: Fennel, A Potent Functional Food for Treatment of Infantile Colic
9. Herbal Therapy: The Best of Perennially Herbal.Fennel In Ameliorated Risk, Progression and Treatment of Prostate cancer
10. Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period
11. Food Therapy; Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period
12. Herbal Therapy: Fennel In Reduced Symptoms and Treatment of Estrogenic Deficiency Related Diseases
13. Eat Fennel to Inhibit Daily Stress in the Workplaces, Scientists Suggested
14. Women’s Health: Protect DNA Integrity Against Breast Cancer with This Single Herb, Online Medical Literature Revealed
15. Food Therapy: Intake Fennel to Optimize the Digestive Functioning in absorbed Nutrients and Fluids
16. Food Therapy: Fennel The Potent Food With Cytoprotection and Antitumor Activity
17. Food Therapy: Fennel and Its Extracts in Detoxed Body Toxins, According to PubMed Online Literature
18. Herbal Therapy: Fennel, A Potent Chemo-Preventive and Modulatory Functional Herb
19. Fennel May Improve Your Heart Functioning Naturally and Permanently, Studies Showed
20. How to Treat Painful Primary Dysmenorrhea Quickly and Permanently, According to PubMed
21. 325. Fennel Seed Extracts That Gobble Up Toxins Caused by Drug Interaction and Toxicity, Scientists Show
22. Fennel, The Best Herbal Remedy Which Detoxes Your Kidneys Through Promoting Excess Fluids Secretion, Public Medical Library Reveal
23. Fennel, The Herbal Remedy Which Protects Our Body Against The Onset of Acute Inflammation and Chronic Inflammatory Diseases, Scientists Find
34. Fennel, A Potent Neurons Protective and Memory Enhancing Functional Herb
35. Fennel, The Reliable and Less Expensive Functional Food For Treatment of Hirsutism
36. Detoxification: Fennel, The Potent and Functional Food Which Protects the Liver Against Toxicity
37. Fennel, The Functional Herb Which Processes Anti Anxiolytic Property Similar to Those of Diazepam with No Adverse Effects, Scientists Find
38. Fennel, The Natural Remedy Which Protects the Brain Neurons Against The Onset of Cognitive Impairment, Scientists Suggest
39. Fennel, the Functional Herb Which Processes Anti-antispasmodic Activity, Scientists Find
40. Fennel, the Best Functional Food Which Processes Anti Hypolipidemic Activity
41. Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find
42. Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find
43. Fennel, a Natural Anti Fever Functional Food
44. Fennel, The Natural Free Radical Scavenger, Scientists Find
45. Fennel Essential Oil and Extract, The Potent Anti Hypoglycemic Remedies, Scientists Reveal
46. Fennel, the Function Food Which Balances the Ratio of the Levels Free Radicals and Antioxidants in Our Body
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Phytochemical 3,3'-Diindolylmethane, a Natural Prevention and Treatment of Delayed-Type Hypersensitivity
Delayed-type hypersensitivity is also known as type 4 hypersensitivity because the reaction takes several days to develop, including contact dermatitis.
Believe it or not, type IV hypersensitivity mediated by antigen-specific effector T cells is associated with the infection induced by slow-growing intracellular organisms, such as M. tuberculosis (tuberculosis), M. leprae (leprosy) and H. capsulatum.
Some researchers suggested that the delayed hypersensitivity is dependent on the presence of a significant number of primed, antigen-specific T cells response which typically reaches its peak 24 to 48 hours after exposure to antigen.
Type IV hypersensitivity diseases although are common, but ranges second to type 1 hypersensitivity.
Many diseases are found to associate with delayed-type hypersensitivity include leprosy, tuberculosis, schistosomiasis, sarcoidosis and Crohn's disease.
* Leprosy is divided clinically into three essential types: tuberculoid, borderline, and lepromatous.
* Schistosomiasis caused by schistosomes, once the body is sensitized by a granulomatous reaction developed in the parasitized tissue mediated by Th2 lymphocytes.
* Tuberculosis in the lungs caused by a granulomatous reaction that leads to cavitation and the spread of bacteria
* Sarcoidosis is a chronic and idiopathic disease caused by the activated macrophage and granuloma accumulation in many tissues along with fibrosis.
* Crohn's disease is a granulomatous disease that is not caused by a microorganism.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
On finding a potential ingredients for the prevention and treatment of the delayed-type hypersensitivity, researchers tested the ability of dietary AhR ligands (indole-3-carbinol [I3C] and 3,3'-diindolylmethane [DIM]) and an endogenous AhR ligand, 6-formylindolo(3,2-b)carbazole (FICZ), on the differentiation and functions of Tregs and Th17 cells.
Administration of indoles (I3C or DIM) in tested mice attenuated delayed-type hypersensitivity (DTH) response to methylated BSA, an antigen-specific inflammation in targeted organs and generation of Th17 cells which play a critical role in the induction of the tissue inflammation and tissue destruction while promoting Tregs in the suppression of immune response.
Interestingly, the indoles inhibited the delayed-type hypersensitivity by causing the reciprocal induction of Tregs and Th17 cells only in wild-type (AhR(+/+)) but not in AhR knockout (AhR(-/-)) mice.
Additional analysis of the indoles anti-delayed-type hypersensitivity activity, researchers found that the efficacy of the indoles was associated with the promotion of protein (FoxP3) involved in immune system responses of the Tregs while decreasing the protein associated with pro-inflammatory expression.
In order to reveal more anti-inflammation about indole-3-carbinol (I3C) and diindolylmethane (DIM), researchers investigated the compounds in the exhibition of the characteristics of aryl hydrocarbon receptor (AhR) ligands, that was found to regulate the T cell differentiation.
In a murine model of multiple sclerosis (MS), retreatment with I3C or DIM completely prevented the clinical symptoms and cellular infiltration into the CNS through induction of inflammation.
Particularly, post-treatment of EAE with I3C or DIM proved highly effective in curtailing the overall severity of the disease.
Similar to that of aforementioned protection against delayed-type hypersensitivity, I3C or DIM promoted the generation of T-regs, while inhibited the induction of MOG-specific Th17 cells.
In other words, I3C or DIM inhibited delayed type hypersensitivity through the promotion of T-regs and suppression of Th17 cells in vivo and in vitro were found to be AhR-dependent.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of delayed type hypersensitivity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory T Cells through Regulation of MicroRNA by Singh NP1, Singh UP1, Rouse M1, Zhang J2, Chatterjee S3, Nagarkatti PS1, Nagarkatti M. (PubMed)
(2) Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells by Rouse M1, Singh NP, Nagarkatti PS, Nagarkatti M. (PubMed)
(3) Delayed Hypersensitivity Reactions by Angel A. Justiz Vaillant; Kamleshun Ramphul.(NCBI)
Believe it or not, type IV hypersensitivity mediated by antigen-specific effector T cells is associated with the infection induced by slow-growing intracellular organisms, such as M. tuberculosis (tuberculosis), M. leprae (leprosy) and H. capsulatum.
Some researchers suggested that the delayed hypersensitivity is dependent on the presence of a significant number of primed, antigen-specific T cells response which typically reaches its peak 24 to 48 hours after exposure to antigen.
Type IV hypersensitivity diseases although are common, but ranges second to type 1 hypersensitivity.
Many diseases are found to associate with delayed-type hypersensitivity include leprosy, tuberculosis, schistosomiasis, sarcoidosis and Crohn's disease.
* Leprosy is divided clinically into three essential types: tuberculoid, borderline, and lepromatous.
* Schistosomiasis caused by schistosomes, once the body is sensitized by a granulomatous reaction developed in the parasitized tissue mediated by Th2 lymphocytes.
* Tuberculosis in the lungs caused by a granulomatous reaction that leads to cavitation and the spread of bacteria
* Sarcoidosis is a chronic and idiopathic disease caused by the activated macrophage and granuloma accumulation in many tissues along with fibrosis.
* Crohn's disease is a granulomatous disease that is not caused by a microorganism.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
On finding a potential ingredients for the prevention and treatment of the delayed-type hypersensitivity, researchers tested the ability of dietary AhR ligands (indole-3-carbinol [I3C] and 3,3'-diindolylmethane [DIM]) and an endogenous AhR ligand, 6-formylindolo(3,2-b)carbazole (FICZ), on the differentiation and functions of Tregs and Th17 cells.
Administration of indoles (I3C or DIM) in tested mice attenuated delayed-type hypersensitivity (DTH) response to methylated BSA, an antigen-specific inflammation in targeted organs and generation of Th17 cells which play a critical role in the induction of the tissue inflammation and tissue destruction while promoting Tregs in the suppression of immune response.
Interestingly, the indoles inhibited the delayed-type hypersensitivity by causing the reciprocal induction of Tregs and Th17 cells only in wild-type (AhR(+/+)) but not in AhR knockout (AhR(-/-)) mice.
Additional analysis of the indoles anti-delayed-type hypersensitivity activity, researchers found that the efficacy of the indoles was associated with the promotion of protein (FoxP3) involved in immune system responses of the Tregs while decreasing the protein associated with pro-inflammatory expression.
In order to reveal more anti-inflammation about indole-3-carbinol (I3C) and diindolylmethane (DIM), researchers investigated the compounds in the exhibition of the characteristics of aryl hydrocarbon receptor (AhR) ligands, that was found to regulate the T cell differentiation.
In a murine model of multiple sclerosis (MS), retreatment with I3C or DIM completely prevented the clinical symptoms and cellular infiltration into the CNS through induction of inflammation.
Particularly, post-treatment of EAE with I3C or DIM proved highly effective in curtailing the overall severity of the disease.
Similar to that of aforementioned protection against delayed-type hypersensitivity, I3C or DIM promoted the generation of T-regs, while inhibited the induction of MOG-specific Th17 cells.
In other words, I3C or DIM inhibited delayed type hypersensitivity through the promotion of T-regs and suppression of Th17 cells in vivo and in vitro were found to be AhR-dependent.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of delayed type hypersensitivity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Indoles Suppress Delayed-Type Hypersensitivity by Inducing a Switch from Proinflammatory Th17 Cells to Anti-Inflammatory Regulatory T Cells through Regulation of MicroRNA by Singh NP1, Singh UP1, Rouse M1, Zhang J2, Chatterjee S3, Nagarkatti PS1, Nagarkatti M. (PubMed)
(2) Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells by Rouse M1, Singh NP, Nagarkatti PS, Nagarkatti M. (PubMed)
(3) Delayed Hypersensitivity Reactions by Angel A. Justiz Vaillant; Kamleshun Ramphul.(NCBI)
Saturday, June 8, 2019
Regular Walking Reduces Risk of Over Weight and visceral or subcutaneous fat accumulation in Older Adults
Visceral or subcutaneous fat accumulation is fat accumulated in the abdominal area, leading to a higher risk of insulin resistance, and its concomitant metabolic disorders (the metabolic syndrome) including atherogenic dyslipidemia(1), in comparison to those with less visceral fat accumulation.
Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but the regular walking contribution of reduced risk of visceral or subcutaneous fat accumulation in the younger and older elderly have been lacking, probably due to its association to the complication of obesity(2).
The study of a total of 173 sedentary, overweight (body mass index > or =24.0 and >33% body fat), postmenopausal women aged 50 to 75 years who were living in the Seattle, Wash, area, suggested, Walking reduced body weight and body fat among overweight and obese postmenopausal women, as it was the most frequently reported activity in the group(3).
Dr. Lynch NA and colleagues at the University of Maryland School of Medicine insisted that walking not only is associated with greater reductions in visceral adiposity in obese postmenopausal women but also improved in maximal O(2) uptake (VO(2 max)(4) of that is said to significantly improve the metabolic profile(5).
In fact, regular walking is found to reduce the risk of visceral or subcutaneous fat accumulation as it prevents the early state of weight gain.
The Okayama Southern Institute of Health in the study of Thirty one obese Japanese males (body mass index (BMI) > or = 25) ranging in age from 32 to 59, participated in a 1-year follow up study said, " intra-abdominal visceral adipose tissue is critically involved in insulin resistance and daily walking rather than improvement of exercise capacity correlated with the reduction of visceral adipose tissue in obese Japanese males."(6). As walking significantly lowers serum leptin concentrations(8), and thus it may improve the leptin resistance observed in overweight adults(7).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Obesity and dyslipidemia in South Asians by Misra A1, Shrivastava U.(PubMed)
(2) [Systolic pressure, abdominal obesity and body fat, metabolic syndrome predictors in Spanish preschoolers].[Article in Spanish] by Gutiérrez Hervás AI1, Rizo Baeza MM2, Martínez Amorós N3, Cortés Castell E4.(PubMed)
(3) Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial by Irwin ML1, Yasui Y, Ulrich CM, Bowen D, Rudolph RE, Schwartz RS, Yukawa M, Aiello E, Potter JD, McTiernan A.(PubMed)
(4) Reductions in visceral fat during weight loss and walking are associated with improvements in VO(2 max) by Lynch NA1, Nicklas BJ, Berman DM, Dennis KE, Goldberg AP.(PubMed)
(5) Is there a threshold of visceral fat loss that improves the metabolic profile in obese postmenopausal women? by Brochu M1, Tchernof A, Turner AN, Ades PA, Poehlman ET.(PubMed)
(6) Daily walking reduces visceral adipose tissue areas and improves insulin resistance in Japanese obese subjects by Miyatake N1, Nishikawa H, Morishita A, Kunitomi M, Wada J, Suzuki H, Takahashi K, Makino H, Kira S, Fujii M.(PubMed)
(7) Physical activity is associated with risk factors for chronic disease across adult women's life cycle by Woolf K1, Reese CE, Mason MP, Beaird LC, Tudor-Locke C, Vaughan LA.(PubMed)
(8) Moderate physical activity permits acute coupling between serum leptin and appetite-satiety measures in obese women by Tsofliou F1, Pitsiladis YP, Malkova D, Wallace AM, Lean ME.(PubMed)
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