Soy and Cancers in Japanese

Soybean is the genus Glycine, belonging to the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein

I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).

A6. Soy and cancers in Japan population
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, become progressively worse and damaged other healthy tissues and sometimes spread to other organs in the body via lymph or blood and results may be in death.

Epidemiological studies, linking soy and soy products in reduced risk and treatment have been contradictive(1)(2)(3)(4), but in Japanese population, soy and its products have been found effective in reduced risks of and treatment of cancers, it may be a result of equol-producer status or long term exposure since childhoods. Some researchers suggested that it may be a result of the traditional Japanese diet with high in soy, vegetables, fish.

1. Breast cancer
Breast cancer (malignant breast neoplasm) is cancer started in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) which supply the ducts with milk. There are also rare cases that breast cancer starts in other areas of the breast.
According to the evaluation based on a systematic review of epidemiologic evidence among the Japanese population, there is no associated of intakes of individual soy foods with the risk of breast cancer but evidence supported the biological plausibility of a protective effect of isoflavones on breast cancer risk(5). The study in the testing of oral administration of IF-rich tablet (20 and 40 mg/day) on climacteric women, showed the product not only reduced risk of breast cancer but also improved of bone density, hypertension, and climacteric symptoms, cardiovascular diseases, gynecological problems and possible immune potentiation(6)
Japanese women have a lower incidence of and mortality from breast cancer, compared to Caucasians, it may be a result of large amount intake soy protein and isoflavones, as high dietary intake of phytoestrogens, mainly in the form of soy products, can produce circulating levels of phytoestrogens that are known experimentally to have oestrogenic effects(7).

2. Lung cancer
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers is derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.
Soy intakes are associated to a reduced risk of lung cancer with epidermal growth factor receptor (EGFR) mutations which play substantial roles in genesis and proliferation of non-small-cell lung cancers (NSCLCs), according to the Aichi Cancer Center Research Institute. (8). In Asian populations, not only Japanese, in the review of total of 11 epidemiological studies that consisted of 8 case-control and 3 prospective cohort studies, although consumption of soy food is associated with lower lung cancer risk, intervention studies that use unified measures of soy intake are needed to fully characterize such an association due to different methods used to assess soy consumption across reviewed studies(9).
Indeed, isoflavone intake was associated with a decreased risk of lung cancer in never smokers, but not in current or past smokers, according to a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999, conducted by the National Cancer Center Tokyo Japan(10).

3. Bowel (Colorectal ) Cancer
Bowel cancer also is known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided into 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progresses cancer and in a predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the Research Center for Cancer Prevention and Screening, National Cancer Center in Japan, in investigated association between dietary soy and isoflavone intake and incidence of colorectal cancer in a prospective cohort study of 83,063 Japanese men and women, ages 45 to 74 years, intake of isoflavones, miso soup, and soy food was not associated with colorectal cancer in either men or women. By colorectal cancer subsite, the risk of proximal colon cancer in men decreased with increasing consumption of isoflavones, miso soup, and soy food in Compared with men in the lowest quartiles of isoflavones(11) and high isoflavone intake was associated with reduced risk of CI and MI in Japanese women, especially in postmenopausal women(12).
But for patients with Acromegaly, a syndrome that results when the anterior pituitary gland produces excess growth hormone (GH), the risk of colorectal cancer is increased substantially(13)(14).

4. Gastric cancer
Stomach cancer is defined as a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
According to the National Cancer Center, Goyang, Korea, high level of consumption of non-fermented soy foods, rather than fermented soyfoods, is associated to reducing GC risk, in the reviews of 20 studies assessing the effect of the consumption of fermented soy food on GC risk(15).
4-hydroxy-2 (or 5)-ethyl-5 (or 2)-methyl-3(2H)-furanone (HEMF), a chemical constituent from of Japanese-style fermented soy sauce, reduced hydrogen peroxide concentration in human polymorphonuclear leucocytes stimulated by arachidonic acid or 12-O-tetradecanoylphorbol-13-acetate,through inhibition of carcinogenesis in this system by acting at the post-initiation stage, in female rats(16). The long-term effect of shoyu (Japanese soy sauce), in the rat study, did not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity but with mild gastritis(17).

5. Cancer of Endometrium/Endometrial Cancer
The endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to the menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of the uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
Greater consumption of isoflavone-containing foods is associated with a reduced risk of endometrial cancer in this population of non-hysterectomized postmenopausal women(18).
In support to the above, the University of Hawaii, in the study of Endometrial cancer cases (n = 332) diagnosed between 1985 and 1993 which were identified from the five main ethnic groups in the state (Japanese, Caucasian, Native Hawaiian, Filipino, and Chinese) through the rapid-reporting system of the Hawaii Tumor Registry, showed that plant-based diets low in calories from fat, high in fiber, and rich in legumes (especially soybeans), whole grain foods, vegetables, and fruits reduce the risk of endometrial cancer(20). According to the National Cancer Center, Tokyo, Japan, in the study of Forty-nine thousand one hundred and twenty-one women of age 45-74 years who responded to a 5-year follow-up survey, researchers found that there was no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk(19).

6. Cervical Cancer
The cervix is the lower part of the uterus that opens at the top of the vagina. The cervix acts a transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus. Cervical cancer is malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.
According to the study by, there was a marginally significant inverse association between CIN3 and tofu and green leafy vegetables among Japanese women(21).

7. Prostate cancer
See The Science of Soy - The East Viewpoints: Part A3 - Soy and Prostate Cancer in Japanese Men

8. Thyroid Cancer
The thyroid is one of the largest endocrine glands found in the neck, below the Adam's Apple with the function of regulating the body use of energy, make of proteins by producing its hormones as a result of the stimulation of thyroid-stimulating hormone (TSH) produced by the anterior pituitary.
Thyroid cancer is defined as a condition in which the cells in the thyroid gland have become cancerous.
According to the National Institute of Health Sciences, Tokyo, Japan, in the evaluation of the proliferating cell nuclear antigen labeling indices elevated in the ID diet(iodine-deficient diet) Female F344 rat groups suggest that isoflavones may not be involved in the mechanisms underlying the synergistic goitrogenic effect of soybean with iodine deficiency(22) but the study by showed the positive effect of dietary defatted soybean in synergistically stimulated the growth of rat thyroid with iodine deficiency, partly through a pituitary-dependent pathway(23). No study was found in the search of the keyword - soy and thyroid cancer in the Japanese population" in PubMed).

Taken altogether, Soy and its by-products may be an association to reduce risk and for treating certain cancers in the Japanese population, including breast, lung, bowel, gastric, prostate, endometrial, cervical cancers, etc. Due to the lack of qualities of the studies found in PubMed, further study may be necessary to improve its validation even in the Japanese population.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model by Andrade JE1, Ju YH, Baker C, Doerge DR, HelferichWG.(PubMed)
(2) Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations by Ju YH1, Allred KF, Allred CD, Helferich WG.(PubMed)
(3) Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth by Gaete L1, Tchernitchin AN, Bustamante R, Villena J, Lemus I, Gidekel M, Cabrera G, Astorga P.(PubMed)
(4) The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein by Pabona JM1, Dave B, Su Y, Montales MT, de Lumen BO, de Mejia EG, Rahal OM, Simmen RC.(PubMed)
(5) Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population by Nagata C1, Mizoue T, Tanaka K, Tsuji I, Tamakoshi A, Matsuo K, Wakai K, Inoue M, Tsugane S, Sasazuki S; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan(PubMed)
(6) Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation by Watanabe S1, Uesugi S, Kikuchi Y.(PubMed)
(7) Phytoestrogens and breast cancer--promoters or protectors? by Rice S1, Whitehead SA.(PubMed)
(8) Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese by Matsuo K1, Hiraki A, Ito H, Kosaka T, Suzuki T, Hirose K, Wakai K, Yatabe Y, Mitsudomi T, Tajima K.(PubMed)
(9) Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies by Yang WS1, Va P, Wong MY, Zhang HL, Xiang YB.(PubMed)
(10) Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan by Shimazu T1, Inoue M, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S; Japan Public Health Center-based Prospective Study Group.(PubMed)
(11) Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study by Akhter M1, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S; Japan Public Health Center-Based Prospective Study Group(PubMed)
(12) Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I by Kokubo Y1, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S; JPHC Study Group.(PubMed)
(13) The prevalence and associated factors of colorectal neoplasms in acromegaly: a single center based study by Yamamoto M1, Fukuoka H, Iguchi G, Matsumoto R, Takahashi M, Nishizawa H, Suda K, Bando H, Takahashi Y.(PubMed)
(14) Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels by Matano Y1, Okada T, Suzuki A, Yoneda T, Takeda Y, Mabuchi H(PubMed)
(15) Fermented and non-fermented soy food consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies by Kim J1, Kang M, Lee JS, Inoue M, Sasazuki S, Tsugane S.(PubMed)
(16) Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia and reduction of H2O2 concentration in human polymorphonuclear leucocytes by flavour components of Japanese-style fermented soy sauce by Kataoka S1, Liu W, Albright K, Storkson J, Pariza M.(PubMed)
(17) Long-term effect of shoyu (Japanese soy sauce) on the gastricmucosa of the rat by MacDonald WC, Dueck JW.(PubMed)
(18) Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study by Ollberding NJ1, Lim U, Wilkens LR, Setiawan VW, Shvetsov YB, Henderson BE, Kolonel LN, Goodman MT.(PubMed)
(19) Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study by Budhathoki S1, Iwasaki M, Sawada N, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S; JPHC Study Group(PubMed)
(20) Association of soy and fiber consumption with the risk of endometrial cancer by Goodman MT1, Wilkens LR, Hankin JH, Lyu LC, Wu AH, Kolonel LN.(PubMed)
(21) Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women by Hosono S1, Matsuo K, Kajiyama H, Hirose K, Suzuki T, Kawase T, Kidokoro K, Nakanishi T, Hamajima N, Kikkawa F, Tajima K, Tanaka H.(PubMed)
(22) Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet by Son HY1, Nishikawa A, Ikeda T, Imazawa T, Kimura S, Hirose M.(PubMed)
(23) Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia by Ikeda T1, Nishikawa A, Imazawa T, Kimura S, Hirose M.(PubMed)

Phytochemical Carotenoids Blocks the Liver cancer Onset and Progression

Liver cancer is a medical condition casued by irregular cell growth in the liver tissue due to the alternation of the cells DNA.

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

Since the organ is a soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

According to the statistic, approximately 42,030 adults (29,480 men and 12,550 women) in the United States will be diagnosed with primary liver cancer in 2019 in the US.

Believe it or not, since 1980, the incidence of liver cancer has tripled. Between 2006 and 2015, the number of people diagnosed with the disease increased by approximately 3% annually.


The exact causes of liver cancer are not identified. However, epidemiologically, age, gender, geography, cirrhosis (severe scarring in the liver) and medical conditions such as diabetes and obesity are some of the most common prevalent factor associated with liver cancer developing.


Some researchers suggested the increased liver cancer incidence may be associated with the promotion of a high-fat diet over the past few decades.

Dr. VanSaun MN, the lead scientist wrote, "Chronic changes induced by the prolonged consumption of a high-fat diet alone culminate in the development of primary liver dysplasias".

And, "High fat diet-induced steatosis, coupled with a splenic injection model of experimental liver metastasis using syngeneic MC38 colon cancer cells, resulted in an increased number of secondary tumor nodules and metastatic burden in steatotic livers. Metastatic nodules were associated with focal peritumoral areas of infiltrating inflammatory cells and associated apoptotic cell populations".

Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

On finding a potential ingredient for the treatment of liver cancer researchers examined the carotenoids effects on hepatocellular carcinoma (HCC) progression.

According to the tested results of the delivery of siFOXC1 using novel carotenoid functionalized dendritic nanoparticles (CDN), the CDN not only displayed a markedly reduced toxicity profile but also achieved ∼90% FOXC1 knockdown.

In other words, the established delivery CDN inhibited the expression of transcription factor FOXC1 which has been found to induce hepatocellular carcinoma (HCC) progression.

Including carotenoids, the CDN achieve the ∼18% greater delivery efficiency compared to treatments of particles with no carotenoid tagging.

Researchers after taking other factors into account said, "thereby emphasizing the role of carotenoid mediated cell internalization in the efficient delivery of CDN-siFOXC1 complex in liver cancer cells".

More precisely, using the aforementioned delivery system, carotenoids are more effective in the inhibition of liver cancer compared to oral injection.

Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Carotenoid Nanovector for Efficient Therapeutic Gene Knockdown of Transcription Factor FOXC1 in Liver Cancer by Misra SK1, Ray T2, Ostadhossein F1, Kim B2, Ray PS2, Pan D. (PubMed)
(2) High fat diet-induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model by VanSaun MN1, Lee IK, Washington MK, Matrisian L, Gorden DL. (PubMed)

Fermented Cucumber, the Natural probiotics With No Side Effects

Probiotics are good bacteria that not only balance the ratio of gut microbiota in the intestine but also react with other body systems to provide optimal health in the human.

Most common types of probiotics are lactobacilli (like Lactobacillus acidophilus and Lactobacillus GG), bifidobacteria (like Bifidobacterium bifidus) and some yeasts (like Saccharomyces boulardii).

Although all probiotics shared the same functions to improve the gastrointestinal microbiome community, different probiotics have different effects.

Most common probiotic foods are
* Yogurt, a dairy product made by fermenting milk is one of the best sources of probiotics. Epidemiologically, yogurt not only provides protein and calcium for the body but also enhance healthy gut bacteria.

Additionally, the fermented products also protect against osteoporosis, irritable bowel disease, and aids digestion.

* Kefir
Kefir is a fermented probiotic milk drink made from kefir grains Kefir or kephir similar to those of thin yogurt.

According to the article by By Megan Ware RDN LD, Kefir as probiotic has been found to process a number of health benefits, including lowering blood pressure, cholesterol, and glucose, improved lactose tolerance, and stomach health, weight control and promoted wound healing.

More precisely,
* In immunity, probiotics stimulate the immune function against inflammatory immune disorders.

* In the digestive system, probiotics protect the gut against gastrointestinal diseases and non-gastrointestinal diseases.caused by overexpression of bad bacteria.

* In metabolism, probiotics influence the nutrient extraction from the diet, thus reducing the risk of obesity and obese complication.

* Neurologically, probiotics control brain insulin signaling and metabolite levels that play a critical role in neurobehaviors.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound with probiotic potential, researchers investigated 3 bacterial strains designated as 437F, 1630F and 1020G were isolated from a traditional pickle.

According to the tested results, all strains showed high acid and bile tolerance and exhibited antagonistic activity against various pathogens.


The straits also demonstrated the antioxidant activity, auto- and co-aggregation ability on the surface hydrophobicity and attachment capacity in the range of other well-known probiotic strains without inducing toxicity.

Dr.Talebi S, the lead scientist wrote at the end of the experiment, "With respect to their characteristics and safety aspect, these Bacillus species may have potential to consider as probiotics for animal and/or human applications".

Additional differentiation of the effect of fermented cucumber activity as probiotics, researchers examined a total of 38 strains which were isolated from the pickled samples.

According to the tested assays, all strain showed a significant resistance after incubation at pH 2.5 did not change markedly, above 90 % (10(9) CFU/mL) survival rate was observed.

More precisely, the strains also exhibited a high survival rate at pH 3.5 (>90 %), compared to all dead at pH 1.5 except four strains that could survive 90 min.

In bile salt solution incubation, at 0.2 %, the survival rates were 81-94 % after 24 h, compared to 59-94 % in 2 and 4 %.

Similar to the aforementioned study, the tested strains also exerted the auto- and co-aggregation ability on the surface hydrophobicity and attachment capacity.

Only four of tested strains were excluded due to safety precautions, according to antibiotic resistance patterns and certain metabolic activities.

In other words, most tested strains isolated from the fermented cucumber process the ability to improve the ratio of microbiota composition in the gut.

Taken altogether, fermented cucumber may be used as probiotics to improve the human digestive health, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Three novel Bacillus strains from a traditional lacto-fermented pickle as potential probiotics by Talebi S1, Makhdoumi A1, Bahreini M1, Matin MM1,2, Moradi HS. (PubMed)
(2) In vitro screening of selected probiotic properties of Lactobacillus strains isolated from traditional fermented cabbage and cucumber by Zielińska D1, Rzepkowska A, Radawska A, Zieliński K. (PubMed)
(3) Seven benefits of kefir By Megan Ware RDN LD. (Medical News Today)

Whole Food Onion Kills Renal Cancer Cells in Vitro

The kidney is an essential organ that not only filters out blood but also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin,

Formed part of the urinary system, kidney filters blood with billions of glomeruli by separating the cells of blood from plasma. During the process, some necessary substances are reabsorbed back into the blood, while others wastes, such as urea and ammonium are stored into pelvis then into the ureter to the bladder.

Kidney cancer is a medical condition caused by malignant cells of the lining of the tubules in the kidney.

At the advanced stage, cancer kidney cells can travel a distance away to infect other healthy tissue and organ through the circulation of blood and fluid, leading to secondary metastasis.

Kidney cancer epidemiologically has been found to spread to the lung.

The exact causes of kidney cancer are not identified. However, the below prevalent factors have been found to induce a higher risk of the disease.
* Gender
Men are twice at risk to develop renal cell carcinoma than women.

* Aging
The onset of renal cell carcinoma has a peak incidence in the 50 but today, the disease has a tendency to affect the younger age population.

* Smoking
Smoking increases the risk of renal cell carcinoma.

* Obesity
Obesity has been associated with an increased risk of renal cell cancer among women, and increased BMI is equally strongly associated with an increased risk of renal cell cancer among men and women.

* Family history
If one of your direct family members has it, your risk of developing renal cell carcinoma increases.

* Chemical toxins
Exposure to certain environment chemical toxins may increase the risk of renal cell carcinoma.

* Cystic kidney disease
This type of genetic disorder of the kidneys accompanied by a renal deficiency can increase the risk of developing kidney cancer.

Because of less nervous in the kidney and location, the early stage of renal cell carcinoma is very hard to detect. In some case, the tumor can grow without causing any pain and discomfort. Most common symptoms are abdominal pain, back pain, blood in the urine, flank pain, anemia, varicocele enlargement, and hypertension.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of kidney cancer

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste, onion is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a natural ingredient for the treatment of renal cancer, researchers examined the effects of fisetin, a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions in human renal carcinoma (Caki) cells.

According to the tested assays, Fisetin induced cancer cell apoptosis by causing cell cycle arrest on the sub-G1 phase.

Futhermore, Fisetin also induced cancer cell apoptosis by activating the proteins (cleavage of poly (ADP-ribose) polymerase (PARP) associated with cell death programming.

Moreover, caspases, the major effectors of apoptosis were also activated by the injection of Fisetin.

Additionally, the efficacy of Fisetin in the inhibition of the renal cancer cell line was also attributed by inducing death receptor 5 (DR5) expression and promoting the gene expression of tumor suppressor (p53).

However, in the differentiation of the effect of another gene (CHOP expression) associated with cellular stress and involved in mediating apoptosis and expression of ROS cytotoxicity, researchers found that fisetin-induced apoptosis without the assistance of CHOP and ROS.

Based on the finding, researchers said, " fisetin induced apoptosis through p53 mediated up-regulation of DR5 expression at the transcriptional level"


Taken altogether, onion used alone or combined with remedies may be considered a remedy for the prevention and treatment of renal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells by Min KJ1, Nam JO2, Kwon TK. (PubMed)
(2) Most common Types of Cancer -Kidney Cancer (Renal Cell Carcinoma) by Kyle J. Norton

Phytochemical Lycopene Gobbles Up Breast Cancer Cells in Vitro

Breast Cancer is a chronic condition associated with the growth of the irregular cells in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.

The 5 years survival rate of the early and localized stage of breast cancer is 100%

Most common signs and symptoms of breast cancer at the early stage include, a painless lump in the breast or armpit and most often discovered by you or your partner may discover the lump or your doctor during a routine physical exam, lump (mass) in the breast, lump in the armpit (lymph nodes), nipple discharge (clear or bloody), inverted or retracted nipple, scaly skin on nipple persistent tenderness of the breast and unusual breast pain or discomfort.

If you have experienced some of the aforementioned symptoms that do not recede in a short period of time, please check with your doctor to rule out the possibility of breast cancer.

In the advanced stage of breast cancer, the cancerous cell not only can travel a distance ways from the breast to infect other healthy tissues and organ, but also induce symptoms of bone pain (Secondary tumors in the bone), shortness of breath (secondary tumors in lung), unintentional weight loss and drop in appetite (Secondary tumors in liver) and headaches, neurological pain or weakness (secondary tumors in the nervous system).


Out of many prevalent factors that cause the onset of breast cancer, some researchers suggested that the promotion of Western diet over the past few decades that cause overweight and obesity in the US may have a strong and negative impact on the breast cancer risk.

Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".

And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women and with worse disease outcome for women of all ages".

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

With an aim to find a plant-based secondary metabolite for the treatment of breast cancer with no side effects, scientists examined lycopene found abundantly in cooked tomato alleviated biological cell oxidative injury and inhibited tumor growth activity.

The study included. MCF-7 cells were treated with different lycopene concentrations for the duration of 24, 48, and 72 h.

According to the tested assays used in the experiment, the application of lycopene showed a significant in cancer cell shrinkage and breakage at a dose and duration-dependent manner compared to untreated breast cancer cells.

Furthermore, lycopene also reduced cell proliferation and increased apoptosis, according to the MTT and Flow cytometry assay.

The cancer cell inhibition was also found by the secondary metabolite in the stimulation of the expression of tumor-suppressive gene p53 and a protein associated with cell apoptosis.


Based on the findings, researchers said, "lycopene inhibits proliferation and facilitates apoptosis of MCF-7 cells in vitro, possibly by regulating the expression of p53 and Bax".


Moreover, breast cancer cell treated by carotenoids (lycopene and beta-carotene) at (0.5-10 μM) for 48 and 96 h, showed a significant decrease in the number of viable breast cancer cells.

In other words, the phytochemical reduced the numbers of active cells compared to the untreated cell line.

Additonally, carotenoids injection also promoted cell-cycle arrest and apoptosis in the majority of cell lines after 96 h, compared to controls.
Dr. Gloria NF, the lead researcher wrote, "These findings indicate that the effect was cell type-dependent and that carotenoids are potential agents for biological interference with cancer".

Taken altogether, lycopene used alone or combined with another phytochemical may be considered supplements for the prevention and treatment of breast cancer, pending on the confirmation of the larger sample size and multicenter human study.


Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro effects and mechanisms of lycopene in MCF-7 human breast cancer cells by Peng SJ1, Li J1, Zhou Y2, Tuo M2, Qin XX2, Yu Q2, Cheng H2, Li YM. (PubMed)
(2) Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines by Gloria NF1, Soares N, Brand C, Oliveira FL, Borojevic R, Teodoro AJ. (PubMed)
(3) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, Ph.D., 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)

Bromelain Blocks the Onset of Endometriosis

Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else instead of the inside of the uterus.

More precisely, on the last stage of the menstrual cycle, instead of a layer of endometriosis lining on the inside of the uterus expelled, known as menstruation blood, some of the endometriosis tissues grow somewhere in the body.

Most endometriosis tissues do not travel far. Most cases of endometriosis are diagnosed within the pelvic region, on the lining of peritoneum, in the ovaries, and on the surface of the uterus's an outside wall, however, the condition can also be found anywhere in the body such as well as fallopian tubes, the cervix, the vagina, and even the vulva.

Believe it or not, about
* 20% of reproductive age women with endometriosis present without symptoms.

*55% of women who have developed the new onset of severe menstrual cramps.

* 25% of women with sub-fertility (less fertile than a normal couple)

Endometriosis can be classified into different stages, depending on the severity of the disease
* Minimal stage:
Commonly they are found on the top surface, of the inside wall of uterus, ligaments, and ovary with a few in numbers.

* Mild stage:
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.

* Moderate stage:
Many implants, endometrial cysts present, affecting ovary function, causing scar tissues and adhesion are also present.

* Severe stage:
Intensive peritoneal implants, large endometromas present and dense adhesion.
Each woman experiences differently to endometriosis. Some women may have extensive endometrial tissues in their body but feel little or no pain at all, compared to other women in the early stage of endometriosis with excessive pain.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the treatment of endometriosis, researchers evaluated the efficacy of an association of N-acetyl cysteine, alpha-lipoic acid, and bromelain (NAC/LA/Br) in vivo murine model and in vitro human endometriotic endothelial cells (EECs) and on endothelial cells isolated from the normal uterus (UtMECs.

In endometrial cells EECs preincubated with NAC/LA/Br, levels of pro-inflammatory cytokines associated with TNF-α were significant reduced observed by lower expression of the inflammatory "marker" VCAM1.

On human endometriotic cysts intraperitoneally into SCID mice, NAC/LA/Br exerted a strong apoptotic activity against EECs without affecting the endothelial cells isolated from the normal uterus (UtMECs).

Furthermore, compared to untreated mice, mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size.

Based on the findings, researchers said, "these dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis".

Moreover, in order to reveal more information about NAC/LA/Br on symptoms of endometriosis, researchers examined the effect of N-acetyl cysteine, alpha lipoic acid, and bromelain on endometriosis- pelvic pain.

In a total, 398 patients with a mean age of 34.6 ± 7.2 years, treatment of the combination of N-acetyl cysteine, alpha lipoic acid, and bromelain for 6 months showed a significant improvement in endometriosis-associated pelvic pain compared to the baseline.

More precisely, compared to the baseline of 92.7% of the patients had pain intensity > 4 on the visual analog scale (VAS); treatment of NAC/LA/Br at 3 months decreased the percentage of patients to 87.2% (p = 0.074) and at 6 months to 82.7%, respectively.

Dr. Lete I, the lead scientist said, "Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics".

Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of endometriosis and endometrial symptoms, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study by Lete I1, Mendoza N2, de la Viuda E3, Carmona F. (PubMed)
(2) The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis by Agostinis C1, Zorzet S2, De Leo R1, Zauli G1, De Seta F3, Bulla R. (PubMed)
(3) Endometriosis part I - Definition, Stages, Symptoms, Causes, and Effects Of Endometriosis by Kyle J. Norton

Herbal Turmeric the Natural Prevention and treatment of Cholecystitis

Cholecystitis is the most common condition caused by the gallbladder stones blockage of the cystic duct, which carries bile from the gallbladder, leading to the inflammation of the gallbladder.

Most common symptoms of cholecystitis are severe pain in your upper right or center abdomen, pain that spreads to your right shoulder or back and tenderness over your abdomen when it's touched.

Some patients may also experience symptoms of nausea, vomiting, and fever due to inflammation.

Cholecystitis can be classified into
* Acute cholecystitis is an inflammation of gallbladders that occurs within hours caused by the obstruction of the stone in the bile duct. Calculous cholecystitis is the most common, and less serious, type of acute cholecystitis. accounting 95% of all cases.

* Chronic cholecystitis is a gallbladder inflammation caused by blockage of gallstone that lasts longer than 12 weeks. Most cases of chronic cholecystitis are associated with prior episodes of acute cholecystitis.

Most common risk factors associated with chronic are cholecystitis, infection of the bile duct drainage system, bile duct blockage and excessive cholesterol in the gallbladder that facilitates the onset of gallstone, and decreased blood supply to the gallbladder due to diabetes.

Conventionally, treatment of chronic cholecystitis totally depending on the severity of the condition such as antibiotics for the infection, medicine to dissolve gallstones and pain relief and surgery.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of cholecystitis, researchers examined the effect of turmeric on cholestasis, a clinically significant symptom and widely associated with liver diseases.


Danning tablet (DNT, a Chinese patent medicine preparation) selected to the study has been clinically used to treat human liver and gallbladder diseases for more than 20 years in China, not only showed significant benefits for the treatment for patients with cholecystitis after cholecystectomy surgery, clinically but also showed protective effect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis model in rodent.

Additional differentiation of the efficacy of DNT in patients with cholecystitis, researchers found that curcumin, the major compound derived from DNT, demonstrated the protective effect against cholestasis through farnesoid X receptor (FXR), which plays a pivotal role in regulating bile acid, lipid, and glucose homeostasis.

Furthermore, curcumin also inhibited the production of pro-inflammatory cytokines that cause gallbladder inflammation by restoring the bile acid homeostasis.

In other words, curcumin protected the gallbladder against the onset of cholecystitis by inhibiting the proteins and signaling pathways in the activation of inflammation of the gallbladder tissues.

Based on the findings, researchers wrote, "Collectively, curcumin can be served as a potential treatment option for liver injury with cholestasis".

Taken altogether, turmeric processed abundantly n=bioactive compound may be used alone or combined with other remedies for the prevention and treatment of cholecystitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation by Fan Yang,1,* Xiaowen Tang,1,* Lili Ding,1 Yue zhou,1 Qiaoling Yang,1 Junting Gong,1Guangyun Wang,1 Zhengtao Wang,a,1 and Li Yang. (PMC)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)