Tuesday, June 25, 2019
Soy and Obesity in Japanese
Soybean is the genus Glycine, belonging to the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A4. Soy and Obesity in Japanese
Soy foods intake is well known for it estrogenic effects because it binds the estrogen receptor with relatively high affinity, but effects induced risk of obesity are inconclusive in the West(1)(2)(3).
It may be results of most Westerner are nonequol producers(4)(5). Some researchers suggested that the prevalence of obesity in the West may be a result of a typical American diet with high in saturated and trans-fat and less in fruits and vegetables. Other blamed the epidemic obesity is a result of an economic environment which make healthy foods more expensive than junks and suggested of taxes on foods with the low nutritional value could nudge behavior toward healthier diets, as could subsidies/discounts for healthier(8). According to a report on NBC by Melissa Dhal, just 10.8 percent of Asians in America are considered obese, a slim percentage when compared with the 33 percent of whites, 42 percent of Hispanics and 48 percent of blacks with a BMI of 30 or higher(7).
In fact, the traditional Japanese diet with a high amount of soy products is associated with a lower BMI in adulthood(9).
According to the Dr. Ma J and the research team, the early exposure to a high-fat diet diminished the abundance of non-pathogenic Campylobacter in the juvenile gut of that may enhance the risk of obesity(10). In fact, DR. Sakata T. said that a very-low-calorie conventional Japanese diet of 370 kcal/day has been shown to be useful for weight reduction and its long-term maintenance(11). and dietary content and food patterns used in management among Japanese patients with type 2 diabetes are quite close to those reported as suitable for prevention of obesity, type 2 diabetes, cardiovascular disease, and total mortality in Europe and America, according to the study of 1,516 patients with type 2 diabetes aged 40-70 years from outpatient clinics in 59 university and general hospitals(12). Regarded to diet habit of the West and Japanese working women, the proportion of eating problems is low in comparison with Western adult populations(15).
Study of Occupational Class Differences in Body Mass Index and Weight Gain in Japan and Finland may provide us with interesting result "BMI was higher at baseline and BMI gain was more rapid in Finland than in Japan, it may be results of clear socioeconomic gradients in obesity in Finland compared to the Japanese environment is less obesogenic than the Finnish environment, or factors such as easy access to fast-food restaurants and limited possibilities for physical exercise are suggested characteristics of an obesogenic environment or due to the Japanese diet has traditionally been very healthy, with high consumption of vegetables, soy protein, and fish, with the general nutritional status of the Japanese population is still healthier than that in many Western countries" (13).
Unfortunately, due to the influence of the West, many Japanese have abandoned the traditional Japanese diet but opted for a quick, high-fat diet with lots of junk foods. According to the Kagawa Nutrition University, Japanese traditional and Western, were all independently and significantly related to the risk of obesity even among a relatively lean young Japanese female population(14).
Other study suggested that adapting maternal Western-style diet consumption may lead to increased susceptibility to type 2 diabetes in the offspring(16), and Western diet increased the risk for atherosclerosis and promoted the progression of preclinical atherosclerosis, in correspondence with the extent of westernization(17). As undergoing rapid "Westernization," , change in Japanese dietary patterns continued, with high intake of butter & margarine, cheese, bread and ham & sausage, etc.(18), the Westernized chronic illness may rise to a level currently found in the "Western" countries in the coming few decades, including diverticular disease, mammary cancers(19)(20).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats by Strakovsky RS1, Lezmi S, Flaws JA, Schantz SL, Pan YX, Helferich WG.(PubMed)
(2) Arginine, soy isoflavone and hydroxypropylmethylcellulose have protective effects against obesity in broiler breeder hens fed on high-energy diets by Khalaji S1, Zaghari M, Ganjkhanloo M, Ghaziani F.(PubMed)
(3) Effects of voluntary running and soy supplementation on diet-induced metabolic disturbance and inflammation in mice by Yan L1, Graef GL, Claycombe KJ, Johnson LK.(PubMed)
(4) Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status by Usui T1, Tochiya M, Sasaki Y, Muranaka K, Yamakage H, Himeno A, Shimatsu A, Inaguma A, Ueno T, Uchiyama S, Satoh-Asahara N.(PubMed)
(5) Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein by Frankenfeld CL1, Atkinson C2, Wähälä K3, Lampe JW4.(PubMed)
(6) Family-focused physical activity, diet and obesity interventions in African-American girls: a systematic review by Barr-Anderson DJ1, Adams-Wynn AW, DiSantis KI, Kumanyika S.(PubMed)
(7). What's actually behind the low Asian-American obesity rate? by Melissa Dahl
(8) Obesity and economic environments by Sturm R1, An R.(PubMed)
(9) Soy intake is related to a lower body mass index in adult women by Maskarinec G1, Aylward AG, Erber E, Takata Y, Kolonel LN.(PubMed)
(10) High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model by Ma J1, Prince AL2, Bader D3, Hu M4, Ganu R4, Baquero K5, Blundell P5, Alan Harris R6, Frias AE5, Grove KL5, Aagaard KM(PubMed)
(11) A very-low-calorie conventional Japanese diet: its implications for prevention of obesity by Sakata T.(PubMed)
(12) Dietary intake in Japanese patients with type 2 diabetes: Analysis from Japan Diabetes Complications Study by Horikawa C1, Yoshimura Y2, Kamada C2, Tanaka S3, Tanaka S4, Takahashi A5, Hanyu O6, Araki A7, Ito H7, Tanaka A8, Ohashi Y5, Akanuma Y9, Yamada N10, Sone H6.(PubMed)
(13) ccupational Class Differences in Body Mass Index and Weight Gain in Japan and Finland
Karri Silventoinen,1 Takashi Tatsuse,2 Pekka Martikainen,1 Ossi Rahkonen,3 Eero Lahelma,3 Michikazu Sekine,2 and Tea Lallukka3,4by PubMed)
(14) Three major dietary patterns are all independently related to the risk of obesity among 3760 Japanese women aged 18-20 years by Okubo H1, Sasaki S, Murakami K, Kim MK, Takahashi Y, Hosoi Y, Itabashi M; Freshmen in Dietetic Courses Study II group.(PubMed)
(15) Eating problems and related weight control behaviour in adult Japanese women by Nakamura K1, Hoshino Y, Watanabe A, Honda K, Niwa S, Yamamoto M.(PubMed)
(16) Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese Macaque model by Pound LD1, Comstock SM2, Grove KL2.(PubMed)
(17) Influence of the extent of westernization of lifestyle on the progression of preclinical atherosclerosis in Japanese subjects by Egusa G1, Watanabe H, Ohshita K, Fujikawa R, Yamane K, Okubo M, Kohno N.(PubMed)
(18) Dietary factors related to higher plasma fibrinogen levels of Japanese-americans in hawaii compared with Japanese in Japan by Miura K1, Nakagawa H, Ueshima H, Okayama A, Saitoh S, Curb JD, Rodriguez BL, Sakata K, Okuda N, Yoshita K, Stamler J; INTERMAP Research Group; INTERLIPID Research Group.(PubMed)
(19) Changes in dietary fiber intake among Japanese in the 20th century: a relationship to the prevalence of diverticular disease by Ohi G, Minowa K, Oyama T, Nagahashi M, Yamazaki N, Yamamoto S, Nagasako K, Hayakawa K, Kimura K, Mori B.(PubMed).
(20) Relationship between westernization of dietary habits and mortality from breast and ovarian cancers in Japan. Kato I, Tominaga S, Kuroishi T.(PubMed)
Herbal Turmeric Reduces the Risk of Diabetic Nephropathy in Diabetes, According to Researchers
Diabetic nephropathy (diabetic kidney disease) is a complication of kidney damage caused by diabetes.
Long-term unmanaged hyperglycemia can damage the part of the kidneys thus reducing the kidney function in filter waste from the blood filters, leading to 'leaky' syndrome that allows protein into your urine.
Diabetic nephropathy is the 3 stage of kidney change in patients with diabetes. In this stage, patients may experience symptoms of abnormally elevated urinary albumin excretion, compared to the 15 and 300 μg/min in the baseline situation.
The progression of diabetic nephropathy that leads to an increased rate in albumin excretion is higher in patients with increased blood pressure.
More importantly, if high blood pressure is left untreated, diabetic nephropathy can induce persistent proteinuria >0.5 g/ 24 h that furtherly decline the renal function with the mean fall rate being around 1 ml/min/mo.
In other words, by treating hypertension and hyperglycemia in patients with diabetes, the progression of diabetics kidney disease may be slowed or preventable.
Some researchers suggested that
* By maintaining a healthy blood glucose levels and keeping them within the target range.
* By a change of healthful diet.
* By getting moderate and regular exercise
* By maintaining a healthy weight
* Particularly, by following a treatment plan, including the use of insulin or other medications.
Most common symptoms of diabetic nephropathy are worsening blood pressure control, protein in the urine, swelling of feet, ankles, hands or eyes, frequent urination, confusion or difficulty concentrating.
If you are diabetes associated with the aforementioned symptoms, please check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential and natural source for the treatment of diabetic complications, researchers examined the effects of bioactive compound curcumin anti-diabetic nephropathy (DN), the most common cause of end-stage renal disease in most parts of the world.
40 patients in the Diabetes Clinic of the Outpatient Department of Shiraz University of Medical Sciences on with overt type 2 diabetic nephropathy were randomized into a trial group (n = 20) and a control group (n = 20).
The treatment group received one capsule with each meal containing 500 mg turmeric, of which 22.1 mg was the active ingredient curcumin (three capsules daily) compared to the control group received three capsules identical in color and size containing starch for the period of 2 months.
Compared to the control group. patients treated with turmeric showed significantly reduced serum levels of transforming growth factor-β (TGF-β) and IL-8 associated with the production of pro-inflammatory cytokine and urinary protein excretion, the indications of kidney dysfunction.
The same results were also found in the comparison of the pre- and post-turmeric supplementation values.
Furthermore, there is no side effect reported in patients of the treatment group.
In other words, turmeric containing curcumin used in the experiment protects the kidney cells against the onset of diabetic nephropathy without inducing any adverse effects.
Dr. Khajehdehi P, the lead scientist based on the finding wrote, "Short-term turmeric supplementation can attenuate proteinuria, TGF-β, and IL-8 in patients with overt type 2 diabetic nephropathy and can be administered as safe adjuvant therapy for these patients".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of diabetic nephropathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of curcumin in experimental diabetic nephropathy by Prabhakar SS. (PubMed)
(2) Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study by Khajehdehi P1, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh G. (PubMed)
(3) The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy by C E Mogensen, C K Christensen and E Vittinghus(The Diabetes Association)
Long-term unmanaged hyperglycemia can damage the part of the kidneys thus reducing the kidney function in filter waste from the blood filters, leading to 'leaky' syndrome that allows protein into your urine.
Diabetic nephropathy is the 3 stage of kidney change in patients with diabetes. In this stage, patients may experience symptoms of abnormally elevated urinary albumin excretion, compared to the 15 and 300 μg/min in the baseline situation.
The progression of diabetic nephropathy that leads to an increased rate in albumin excretion is higher in patients with increased blood pressure.
More importantly, if high blood pressure is left untreated, diabetic nephropathy can induce persistent proteinuria >0.5 g/ 24 h that furtherly decline the renal function with the mean fall rate being around 1 ml/min/mo.
In other words, by treating hypertension and hyperglycemia in patients with diabetes, the progression of diabetics kidney disease may be slowed or preventable.
Some researchers suggested that
* By maintaining a healthy blood glucose levels and keeping them within the target range.
* By a change of healthful diet.
* By getting moderate and regular exercise
* By maintaining a healthy weight
* Particularly, by following a treatment plan, including the use of insulin or other medications.
Most common symptoms of diabetic nephropathy are worsening blood pressure control, protein in the urine, swelling of feet, ankles, hands or eyes, frequent urination, confusion or difficulty concentrating.
If you are diabetes associated with the aforementioned symptoms, please check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential and natural source for the treatment of diabetic complications, researchers examined the effects of bioactive compound curcumin anti-diabetic nephropathy (DN), the most common cause of end-stage renal disease in most parts of the world.
40 patients in the Diabetes Clinic of the Outpatient Department of Shiraz University of Medical Sciences on with overt type 2 diabetic nephropathy were randomized into a trial group (n = 20) and a control group (n = 20).
The treatment group received one capsule with each meal containing 500 mg turmeric, of which 22.1 mg was the active ingredient curcumin (three capsules daily) compared to the control group received three capsules identical in color and size containing starch for the period of 2 months.
Compared to the control group. patients treated with turmeric showed significantly reduced serum levels of transforming growth factor-β (TGF-β) and IL-8 associated with the production of pro-inflammatory cytokine and urinary protein excretion, the indications of kidney dysfunction.
The same results were also found in the comparison of the pre- and post-turmeric supplementation values.
Furthermore, there is no side effect reported in patients of the treatment group.
In other words, turmeric containing curcumin used in the experiment protects the kidney cells against the onset of diabetic nephropathy without inducing any adverse effects.
Dr. Khajehdehi P, the lead scientist based on the finding wrote, "Short-term turmeric supplementation can attenuate proteinuria, TGF-β, and IL-8 in patients with overt type 2 diabetic nephropathy and can be administered as safe adjuvant therapy for these patients".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of diabetic nephropathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of curcumin in experimental diabetic nephropathy by Prabhakar SS. (PubMed)
(2) Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study by Khajehdehi P1, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh G. (PubMed)
(3) The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy by C E Mogensen, C K Christensen and E Vittinghus(The Diabetes Association)
Monday, June 24, 2019
Soy and Menopause Symptoms in Japanese
Soybean, the genus Glycine, belonging to the family Fabaceae, one of the legumes contains twice as much protein per acre than any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A5. Soy and menopause symptom in Japan
Menopause is defined as a condition in which women have not had a menstrual period in a minimum of 12 months period as a result of the inactive ovaries, assuming the women are not pregnant and experience the ease of visible symptoms of menopause such as hot flashes and night sweats but not the invisible effects of menopause. During postmenopause, any bleeding or spotting should be reported to your doctor immediately, because it may be caused by tumors rarely but it is possible. Symptoms may include Bleeding or spotting, Vagina itching and dryness, Hot flash, Bone pain, and fracture, Bladder infection, Skin wrinkle, Hypertension, Bone density loss, etc.
Epidemiological studies, linking soy effects on menopause symptoms have been inconclusive(1)(2)(3)(4). In Japanese women, phytochemicals in soy found effectively in reduced vasomotor symptoms of menopause. In the study of a supplement containing equol on the menopausal symptoms in Japanese, researchers at the Tokyo Medical and Dental University, showed that the equol-ingesting group, not only significantly reduces severity and frequency of hot flashes, neck or shoulder but also exhibited trends of improvement in sweating and irritability and a significant improvement in the somatic category symptoms(5). Administration of 10-mg natural S-(-)equol supplement consumed daily for 12 weeks also indicated a reduction of hot flushes and neck or shoulder muscle stiffness, in postmenopausal Japanese women(6). And fermented soy products have been also showed to alleviate the severity of hot flushes(14).
Some researchers suggested that the effectiveness of soy isoflavone in relieving symptoms of menopause may link to equol-producing status. In a 1-year double-blind, randomized trial in comparison of the effects of isoflavone (75 mg of isoflavone conjugates/day) in early postmenopausal equol-producer phenotype Japanese women, found that isoflavones exhibit the preventive effects on bone loss and fat accumulation in early postmenopausal women, depending on an individual's equol-producing capacity(7) and S-equol supplement improved mood-related symptoms in perimenopausal/postmenopausal even in equol nonproducers in Japan women, in total of 127 participants completed the trial(8).
Soy isoflavone extracts on testing on the lumbar spine or hip BMD in menopausal women of controlled trials published in English, Japanese, or Chinese, showed a result of varying effects on spine BMD(9). In comparing the symptom of hot flash and chilliness in menopause women, Dr. Melby MK. suggested that Japanese women experience important vasomotor symptom than hot flushes and sweats, it may be a result of dietary high in soy(10).
In Osteoporosis, menaquinone-7, the major chemical compound found in Japanese fermented soybeans, showed to prevent postmenopausal bone loss(11) and promote bone formation(13)(15) as well alleviating early postmenopausal women symptoms, such as in palpitation and backaches(15). Another study also suggested that intake of supplementation of isoflavones (ISO) regular associates to risk reduction of osteoporosis in middle-aged Japanese and menopausal Japanese women(12).
In fact, according to the study of cross-sectional relationships of dietary and other lifestyle variables to menopause by the Gifu University School of Medicine, such as smoking, calcium, and soy product intakes, intakes of fat, cholesterol, and coffee were significantly associated with the onset menopause in Japanese women(16).
Taken altogether, High soy food intakes are associated to reduce symptoms of menopause in Japanese women, especially in the major menopausal symptom of chilliness. Intake of a supplement containing equol is effective in symptom reduction even in nonequol producers in these population as well. According to the Royal Hospital for Women, the highest soy consumption in Japan lowered the rates of diseases, including breast, endometrial, colon and prostatic cancers atherosclerotic, etc. The induced extremely high urinary levels of phytoestrogen metabolites may be a result of isoflavones in exhibited bioactivity when intake of high concentrations. (17)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) The Science of Soy: What Do We Really Know? by Julia R. Barrett
(b) Guideline for healthy soy intake(the Unite Soybean board)
(1c) Japan, Wikipedia
(1a) Erdman JW Jr. AHA Science Advisory: soy protein and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation. 2000; 102: 2555–2559
(Soy protein and cardiovascular disease)
(1b) van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation. 2005; 111: 465–471(Cardiovascular diseases in women)
(1) S-equol and the fermented soy product SE5-OH containing S-equol similarly decrease ovariectomy-induced increase in rat tail skin temperature in an animal model of hot flushes by Yoneda T1, Ueno T, Uchiyama S.(PubMed)
(2) A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency by Jenks BH1, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson WH, Ueno T, Uchiyama S.(PubMed)
(3) Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials by Taku K1, Melby MK, Kronenberg F, Kurzer MS, Messina M.(PubMed)
(4) Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial by Newton KM1, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J.(PubMed)
(5) Equol improves menopausal symptoms in Japanese women by Aso T.(PubMed)
(6) A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women by Aso T1, Uchiyama S, Matsumura Y, Taguchi M, Nozaki M, Takamatsu K, Ishizuka B, Kubota T, Mizunuma H, Ohta H.(PubMed)
(7) Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial by Wu J1, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y.(PubMed)
(8) New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women by Ishiwata N1, Melby MK, Mizuno S, Watanabe S.(PubMed)
(9) Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials by Taku K1, Melby MK, Takebayashi J, Mizuno S, Ishimi Y, Omori T, Watanabe S.(PubMed)
(10) Chilliness: a vasomotor symptom in Japan by Melby MK.(PubMed)
(11) Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study by Ikeda Y1, Iki M, Morita A, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H.(PubMed)
(12) Soy isoflavone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women by Mori M1, Aizawa T, Tokoro M, Miki T, Yamori Y.(PubMed)
(13) Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women by Katsuyama H1, Ideguchi S, Fukunaga M, Fukunaga T, Saijoh K, Sunami S.(PubMed)
(14) Hot flushes and other menopausal symptoms in relation to soyproduct intake in Japanese women by Nagata C1, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.(PubMed)
(15) Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women by Somekawa Y1, Chiguchi M, Ishibashi T, Aso T.(PubMed)
(16) Association of diet and other lifestyle with onset of menopause in Japanese women by Nagata C1, Takatsuka N, Inaba S, Kawakami N, Shimizu H.(PubMed)
(17) Phytoestrogens and the menopause by Mackey R1, Eden J.(PubMed)
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A5. Soy and menopause symptom in Japan
Menopause is defined as a condition in which women have not had a menstrual period in a minimum of 12 months period as a result of the inactive ovaries, assuming the women are not pregnant and experience the ease of visible symptoms of menopause such as hot flashes and night sweats but not the invisible effects of menopause. During postmenopause, any bleeding or spotting should be reported to your doctor immediately, because it may be caused by tumors rarely but it is possible. Symptoms may include Bleeding or spotting, Vagina itching and dryness, Hot flash, Bone pain, and fracture, Bladder infection, Skin wrinkle, Hypertension, Bone density loss, etc.
Epidemiological studies, linking soy effects on menopause symptoms have been inconclusive(1)(2)(3)(4). In Japanese women, phytochemicals in soy found effectively in reduced vasomotor symptoms of menopause. In the study of a supplement containing equol on the menopausal symptoms in Japanese, researchers at the Tokyo Medical and Dental University, showed that the equol-ingesting group, not only significantly reduces severity and frequency of hot flashes, neck or shoulder but also exhibited trends of improvement in sweating and irritability and a significant improvement in the somatic category symptoms(5). Administration of 10-mg natural S-(-)equol supplement consumed daily for 12 weeks also indicated a reduction of hot flushes and neck or shoulder muscle stiffness, in postmenopausal Japanese women(6). And fermented soy products have been also showed to alleviate the severity of hot flushes(14).
Some researchers suggested that the effectiveness of soy isoflavone in relieving symptoms of menopause may link to equol-producing status. In a 1-year double-blind, randomized trial in comparison of the effects of isoflavone (75 mg of isoflavone conjugates/day) in early postmenopausal equol-producer phenotype Japanese women, found that isoflavones exhibit the preventive effects on bone loss and fat accumulation in early postmenopausal women, depending on an individual's equol-producing capacity(7) and S-equol supplement improved mood-related symptoms in perimenopausal/postmenopausal even in equol nonproducers in Japan women, in total of 127 participants completed the trial(8).
Soy isoflavone extracts on testing on the lumbar spine or hip BMD in menopausal women of controlled trials published in English, Japanese, or Chinese, showed a result of varying effects on spine BMD(9). In comparing the symptom of hot flash and chilliness in menopause women, Dr. Melby MK. suggested that Japanese women experience important vasomotor symptom than hot flushes and sweats, it may be a result of dietary high in soy(10).
In Osteoporosis, menaquinone-7, the major chemical compound found in Japanese fermented soybeans, showed to prevent postmenopausal bone loss(11) and promote bone formation(13)(15) as well alleviating early postmenopausal women symptoms, such as in palpitation and backaches(15). Another study also suggested that intake of supplementation of isoflavones (ISO) regular associates to risk reduction of osteoporosis in middle-aged Japanese and menopausal Japanese women(12).
In fact, according to the study of cross-sectional relationships of dietary and other lifestyle variables to menopause by the Gifu University School of Medicine, such as smoking, calcium, and soy product intakes, intakes of fat, cholesterol, and coffee were significantly associated with the onset menopause in Japanese women(16).
Taken altogether, High soy food intakes are associated to reduce symptoms of menopause in Japanese women, especially in the major menopausal symptom of chilliness. Intake of a supplement containing equol is effective in symptom reduction even in nonequol producers in these population as well. According to the Royal Hospital for Women, the highest soy consumption in Japan lowered the rates of diseases, including breast, endometrial, colon and prostatic cancers atherosclerotic, etc. The induced extremely high urinary levels of phytoestrogen metabolites may be a result of isoflavones in exhibited bioactivity when intake of high concentrations. (17)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) The Science of Soy: What Do We Really Know? by Julia R. Barrett
(b) Guideline for healthy soy intake(the Unite Soybean board)
(1c) Japan, Wikipedia
(1a) Erdman JW Jr. AHA Science Advisory: soy protein and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation. 2000; 102: 2555–2559
(Soy protein and cardiovascular disease)
(1b) van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation. 2005; 111: 465–471(Cardiovascular diseases in women)
(1) S-equol and the fermented soy product SE5-OH containing S-equol similarly decrease ovariectomy-induced increase in rat tail skin temperature in an animal model of hot flushes by Yoneda T1, Ueno T, Uchiyama S.(PubMed)
(2) A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency by Jenks BH1, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson WH, Ueno T, Uchiyama S.(PubMed)
(3) Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials by Taku K1, Melby MK, Kronenberg F, Kurzer MS, Messina M.(PubMed)
(4) Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial by Newton KM1, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J.(PubMed)
(5) Equol improves menopausal symptoms in Japanese women by Aso T.(PubMed)
(6) A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women by Aso T1, Uchiyama S, Matsumura Y, Taguchi M, Nozaki M, Takamatsu K, Ishizuka B, Kubota T, Mizunuma H, Ohta H.(PubMed)
(7) Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial by Wu J1, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y.(PubMed)
(8) New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women by Ishiwata N1, Melby MK, Mizuno S, Watanabe S.(PubMed)
(9) Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials by Taku K1, Melby MK, Takebayashi J, Mizuno S, Ishimi Y, Omori T, Watanabe S.(PubMed)
(10) Chilliness: a vasomotor symptom in Japan by Melby MK.(PubMed)
(11) Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study by Ikeda Y1, Iki M, Morita A, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H.(PubMed)
(12) Soy isoflavone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women by Mori M1, Aizawa T, Tokoro M, Miki T, Yamori Y.(PubMed)
(13) Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women by Katsuyama H1, Ideguchi S, Fukunaga M, Fukunaga T, Saijoh K, Sunami S.(PubMed)
(14) Hot flushes and other menopausal symptoms in relation to soyproduct intake in Japanese women by Nagata C1, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.(PubMed)
(15) Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women by Somekawa Y1, Chiguchi M, Ishibashi T, Aso T.(PubMed)
(16) Association of diet and other lifestyle with onset of menopause in Japanese women by Nagata C1, Takatsuka N, Inaba S, Kawakami N, Shimizu H.(PubMed)
(17) Phytoestrogens and the menopause by Mackey R1, Eden J.(PubMed)
Onion Blocks the Initiation of Prostate Cancer
The prostate warped around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.
The prostate gland is considered a reproductive organ in men.
Prostate cancer is a medical condition caused by cell growth disorderly in the prostate tissue due to the alternation of DNA.
At the advanced stage, the cancerous cell in the prostate can spread to the distance away to inject other healthy tissue and organ, leading to a secondary metastasis through lymph and blood.
Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.
According to the statistics provided by the American Cancer Society, approximately 174,650 cases of prostate cancer will be diagnosed in 2019. Prostate cancer will cause the death of 31620 Americans.
The exact causes of prostate cancer are not known. However, epidemiologically, below are some of the most prevalent factors associated with prostate cancer risk
*Age
The risk of developing prostate cancer increases with the age of over 45
* Family history
Statistic showed that if one of your directed family members has prostate cancer, you are twice at risk to develop it as well.
*Race
Prostate cancer is more likely to strike black and white or Hispanic men in the US.
* Heredity
Certain genes mutation is associated in promoting the growth of prostate cancer, including hereditary prostate cancer gene 1 (HPC1), transmembrane protease, serine 2-ERG or transmembrane protease, serine 2-ETV1/4, etc.
Researchers found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are a late event in pathology of prostate cancer.
* Low levels of vitamin D in the blood
Researchers found that men with a deficiency of level of vitamin D in the blood are at higher risk to develop prostate cancer.
* Excessive drinking
Excessive drink not only increases the risk of liver cancer but also associated with a higher risk of prostate cancer as it interferes with folate metabolism. Risk of prostate cancer is much high for men with excessive drinking habit and folate deficiency.
* Enlarged prostate
Men with an enlarged prostate are at high risk in developing prostate cancer.
* Sexual transmitting diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with a higher risk of the diseases.
*Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the promotion of prostate health, researchers examined the effect of onion on prostate cancer in vivo and vitro.
According to a population-based case-control study in Shanghai, Hsing et. al. participants in the highest of 3 intake categories of total Allium vegetables, including onion showed a significant effect in reducing the risk of prostate cancer with the relative odds ratio risk of .53 compared to those with the lowest intake.
In the Italian and Swiss case-control networks study, researchers surprisingly showed that participants with the highest intake of both onions do not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, according to the differentiation, there was evidence of a trend of decreased odds with increasing intake.
In other words, over time, increased intake of onion may have significant activity in reducing the prostate cancer risk.
The results strongly suggested, over time, regular consumption may decrease the risk of prostate cancer, depending on the amount of onion intake daily.
Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Prostate Cancer by Kyle J. Norton
The prostate gland is considered a reproductive organ in men.
Prostate cancer is a medical condition caused by cell growth disorderly in the prostate tissue due to the alternation of DNA.
At the advanced stage, the cancerous cell in the prostate can spread to the distance away to inject other healthy tissue and organ, leading to a secondary metastasis through lymph and blood.
Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.
According to the statistics provided by the American Cancer Society, approximately 174,650 cases of prostate cancer will be diagnosed in 2019. Prostate cancer will cause the death of 31620 Americans.
The exact causes of prostate cancer are not known. However, epidemiologically, below are some of the most prevalent factors associated with prostate cancer risk
*Age
The risk of developing prostate cancer increases with the age of over 45
* Family history
Statistic showed that if one of your directed family members has prostate cancer, you are twice at risk to develop it as well.
*Race
Prostate cancer is more likely to strike black and white or Hispanic men in the US.
* Heredity
Certain genes mutation is associated in promoting the growth of prostate cancer, including hereditary prostate cancer gene 1 (HPC1), transmembrane protease, serine 2-ERG or transmembrane protease, serine 2-ETV1/4, etc.
Researchers found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are a late event in pathology of prostate cancer.
* Low levels of vitamin D in the blood
Researchers found that men with a deficiency of level of vitamin D in the blood are at higher risk to develop prostate cancer.
* Excessive drinking
Excessive drink not only increases the risk of liver cancer but also associated with a higher risk of prostate cancer as it interferes with folate metabolism. Risk of prostate cancer is much high for men with excessive drinking habit and folate deficiency.
* Enlarged prostate
Men with an enlarged prostate are at high risk in developing prostate cancer.
* Sexual transmitting diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with a higher risk of the diseases.
*Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the promotion of prostate health, researchers examined the effect of onion on prostate cancer in vivo and vitro.
According to a population-based case-control study in Shanghai, Hsing et. al. participants in the highest of 3 intake categories of total Allium vegetables, including onion showed a significant effect in reducing the risk of prostate cancer with the relative odds ratio risk of .53 compared to those with the lowest intake.
In the Italian and Swiss case-control networks study, researchers surprisingly showed that participants with the highest intake of both onions do not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, according to the differentiation, there was evidence of a trend of decreased odds with increasing intake.
In other words, over time, increased intake of onion may have significant activity in reducing the prostate cancer risk.
The results strongly suggested, over time, regular consumption may decrease the risk of prostate cancer, depending on the amount of onion intake daily.
Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Prostate Cancer by Kyle J. Norton
Sunday, June 23, 2019
Herbal Turmeric Ameliorates Symptoms of Biliary Dyskinesia, Researchers Say
Biliary dyskinesia is a medical disorder associated with the gallbladder and sphincter of oddi affecting the biliary system to facilitate the normal flow of the bile.
Some researchers suggested that the condition is a symptom of bladder disease such as cholecystitis, gallstone or pancreatitis, rather than being a disease itself.
Mose common symptom is pain on the right upper quadrant where the gallbladder located.
However, some patients may also experience the symptom of pain that does not stop with medication, including pain in the under the ribs and in the back right shoulder blade.
Other patients may also experience symptoms of nausea and vomiting, indigestion, bloating and belching.
If you have experience persistently aforementioned pain that can be relieved by medication, please check with your doctor to rule out the possibility.
The cause of biliary dyskinesia is unknown. However, researchers do know that people who are in older age, obesity group, and female gender are at a higher risk of the condition.
Believe it or not, women who are or who have been pregnant, taking birth control pills or in their menopausal years are at substantial risk of biliary dyskinesia developing compared to others.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the treatment of biliary dyskinesia, researchers investigated the turmeric effect on the right upper abdominal pain in biliary dyskinesia patients.
74 patients with the condition were selected into the trial, randomly assigned to either received Cholagogum (dried extracts from Schöllkraut and Curcuma) (39 patients) or placebo (37 patients) for 3 weeks.
According to the tested assays, dumpy and colicky pain was more rapid during the first treatment week in Cholagogum F group compared to placebo.
However, both groups exerted similar effects in reducing the feeling of being filled up, food intolerance, nausea, vomiting, meteorism, during the whole treatment period.
There are no side-effects in the treatment group.
In other words, dried extracts from Schöllkraut and Curcuma inhibited the symptoms of biliary dyskinesia, without inducing any side effects.
Dr. Niederau C the lead scientist after taking into account co and confounders said, "The study presents the first solid indication that extracts from Schöllkraut/Curcuma (Cholagogum F Nattermann) which have widely been used in daily practice for many decades have beneficial effects on pain due to biliary dyskinesia".
Taken altogether, turmeric used alone or combined with another remedy may be considered supplements for the treatment of the symptoms of biliary dyskinesia,, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [The effect of chelidonium- and turmeric root extract on upper abdominal pain due to functional disorders of the biliary system. Results from a placebo-controlled double-blind study].[Article in German] by Niederau C1, Göpfert E. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
Some researchers suggested that the condition is a symptom of bladder disease such as cholecystitis, gallstone or pancreatitis, rather than being a disease itself.
Mose common symptom is pain on the right upper quadrant where the gallbladder located.
However, some patients may also experience the symptom of pain that does not stop with medication, including pain in the under the ribs and in the back right shoulder blade.
Other patients may also experience symptoms of nausea and vomiting, indigestion, bloating and belching.
If you have experience persistently aforementioned pain that can be relieved by medication, please check with your doctor to rule out the possibility.
The cause of biliary dyskinesia is unknown. However, researchers do know that people who are in older age, obesity group, and female gender are at a higher risk of the condition.
Believe it or not, women who are or who have been pregnant, taking birth control pills or in their menopausal years are at substantial risk of biliary dyskinesia developing compared to others.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the treatment of biliary dyskinesia, researchers investigated the turmeric effect on the right upper abdominal pain in biliary dyskinesia patients.
74 patients with the condition were selected into the trial, randomly assigned to either received Cholagogum (dried extracts from Schöllkraut and Curcuma) (39 patients) or placebo (37 patients) for 3 weeks.
According to the tested assays, dumpy and colicky pain was more rapid during the first treatment week in Cholagogum F group compared to placebo.
However, both groups exerted similar effects in reducing the feeling of being filled up, food intolerance, nausea, vomiting, meteorism, during the whole treatment period.
There are no side-effects in the treatment group.
In other words, dried extracts from Schöllkraut and Curcuma inhibited the symptoms of biliary dyskinesia, without inducing any side effects.
Dr. Niederau C the lead scientist after taking into account co and confounders said, "The study presents the first solid indication that extracts from Schöllkraut/Curcuma (Cholagogum F Nattermann) which have widely been used in daily practice for many decades have beneficial effects on pain due to biliary dyskinesia".
Taken altogether, turmeric used alone or combined with another remedy may be considered supplements for the treatment of the symptoms of biliary dyskinesia,, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [The effect of chelidonium- and turmeric root extract on upper abdominal pain due to functional disorders of the biliary system. Results from a placebo-controlled double-blind study].[Article in German] by Niederau C1, Göpfert E. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
Healthy Food Tomato Promotes Immunomodulatory Activity Against the Onset of Colitis In Vivo
Colitis is chronic a condition associated with the inflammation of the large intestine, including the colon, caecum, and rectum.
Colitis can be classified into the microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis and Behcet's colitis(a), according to the Catholic University of the Sacred Heart.
Most common symptoms of colitis are totally depending on the types. However, the general symptoms include
* Adnominal pain and diarrhea
There is a report of a 25-year-old Iranian gentleman was admitted to hospital with severe bloody diarrhea and abdominal pain as a result of herbal-induced weight loss adverse effects. On flexible sigmoidoscopy, a continuous length of congested mucosa with multiple small ulcers was seen extending up to the mid-transverse colon, in keeping with ulcerative colitis, according to the study by
Homerton University Hospital NHS Foundation Trust(1)
2. Bleeding per rectum
Acute ischaemic colitis (AIC) is being increasingly recognized as an uncommon cause of abdominal pain associated with fresh bleeding per rectum and diarrhea, according to the study by University Central Hospital(2).
3. Distention with bloody diarrhea
The typical clinical presentation is acute sudden abdominal pain and distention with bloody diarrhea(3).
4. Abdominal bloating and flatulence
In the study to estimate the prevalence of microscopic colitis and SIBO in patients with IBS, to evaluate the symptoms and the efficacy of treatment found that out of the 132 patients initially diagnosed with IBS 3% (n=4) had microscopic colitis and 43.9% (n=58) had SIBO. Diarrhea was the main symptom in patients with microscopic colitis and SIBO (p=0.041), while abdominal pain, abdominal bloating and flatulence were prominent in IBS patients (p=0.042; p=0.039; p=0.048)(4).
5. Changes in bowel habits
Abdominal pain, bloating, early satiety, and changes in bowel habits are common presenting symptoms in individuals with functional GI disorders(5).
6. Fever and severe dehydration
There is a report of a 19-year-old man with a 1-year history of ulcerative colitis presented with fever, bloody diarrhea, and severe dehydration. He was on po.48 mg methylprednisolone and 3 g mesalazine daily and has recently finished taking clarithromycin for Campylobacter jejuni infection(6).
7. Urgency
The study to examine the differing perspectives and perceptual gaps relating to ulcerative colitis (UC) symptoms and their management between patients and healthcare professionals (HCPs), indicated that fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life over the same period. Patients ranked urgency and pain as the most bothersome symptoms(7)
8. Other symptoms
There is a report of a case of a 51-year-old Caucasian male who was evaluated for abdominal pain, elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea as a result of granulomatous enterocolitis. due to Sarcoidosis(8). Other study conducted by Anhui University of Traditional Chinese Medicine, with rats in the model group, showed lethargy, poor appetite, loss of energy, diarrhea and bloody stool(9).
If you have experienced some of the aforementioned symptoms persistently with no signs of stopping, please make sure you check with your doctor to rule out the possibility of colitis.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding healthy foods for the treatment of colitis, researchers examined the impact of tomato lycopene extract (TLE) on intestinal inflammation.
The study included mice lipopolysaccharide (LPS)-induced innate signaling and experimental colitis fed a diet containing 0.5 and 2% TLE or isoflavone free control (AIN-76).
According to the tested assays, TLE blocked LPS-induced IkappaBalpha degradation and RelA translocation associated with the onset of colitis by blocking the inhibition of the protein involved in cytokine production.
Futhermore, MIP-2, a small cytokine mRNA accumulation in IEC-18 cells and pro-inflammatory cytokine Interleukin 12 (IL-12) induced by LPS were inhibited by the injection of TLE.
Moreover, application of TLE also increased the expression of anti-inflammatory cytokines IL-6, TNF-alpha, a regulator of inflammation and MCP-1 mRNA associated with macrophage recruitment in the colon of TLE-fed subjects.
The results strongly suggested that tomato extract inhibited the colitis in mice through its modulatory of immune and inflammatory activity.
Taken altogether, tomato may be considered a dietary supplements for the prevention and treatment of colitis, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice by Joo YE1, Karrasch T, Mühlbauer M, Allard B, Narula A, Herfarth HH, Jobin C. (PubMed)
(2) Colitis - Types and Symptoms by Kyle J. Norton
Colitis can be classified into the microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis and Behcet's colitis(a), according to the Catholic University of the Sacred Heart.
Most common symptoms of colitis are totally depending on the types. However, the general symptoms include
* Adnominal pain and diarrhea
There is a report of a 25-year-old Iranian gentleman was admitted to hospital with severe bloody diarrhea and abdominal pain as a result of herbal-induced weight loss adverse effects. On flexible sigmoidoscopy, a continuous length of congested mucosa with multiple small ulcers was seen extending up to the mid-transverse colon, in keeping with ulcerative colitis, according to the study by
Homerton University Hospital NHS Foundation Trust(1)
2. Bleeding per rectum
Acute ischaemic colitis (AIC) is being increasingly recognized as an uncommon cause of abdominal pain associated with fresh bleeding per rectum and diarrhea, according to the study by University Central Hospital(2).
3. Distention with bloody diarrhea
The typical clinical presentation is acute sudden abdominal pain and distention with bloody diarrhea(3).
4. Abdominal bloating and flatulence
In the study to estimate the prevalence of microscopic colitis and SIBO in patients with IBS, to evaluate the symptoms and the efficacy of treatment found that out of the 132 patients initially diagnosed with IBS 3% (n=4) had microscopic colitis and 43.9% (n=58) had SIBO. Diarrhea was the main symptom in patients with microscopic colitis and SIBO (p=0.041), while abdominal pain, abdominal bloating and flatulence were prominent in IBS patients (p=0.042; p=0.039; p=0.048)(4).
5. Changes in bowel habits
Abdominal pain, bloating, early satiety, and changes in bowel habits are common presenting symptoms in individuals with functional GI disorders(5).
6. Fever and severe dehydration
There is a report of a 19-year-old man with a 1-year history of ulcerative colitis presented with fever, bloody diarrhea, and severe dehydration. He was on po.48 mg methylprednisolone and 3 g mesalazine daily and has recently finished taking clarithromycin for Campylobacter jejuni infection(6).
7. Urgency
The study to examine the differing perspectives and perceptual gaps relating to ulcerative colitis (UC) symptoms and their management between patients and healthcare professionals (HCPs), indicated that fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life over the same period. Patients ranked urgency and pain as the most bothersome symptoms(7)
8. Other symptoms
There is a report of a case of a 51-year-old Caucasian male who was evaluated for abdominal pain, elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea as a result of granulomatous enterocolitis. due to Sarcoidosis(8). Other study conducted by Anhui University of Traditional Chinese Medicine, with rats in the model group, showed lethargy, poor appetite, loss of energy, diarrhea and bloody stool(9).
If you have experienced some of the aforementioned symptoms persistently with no signs of stopping, please make sure you check with your doctor to rule out the possibility of colitis.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding healthy foods for the treatment of colitis, researchers examined the impact of tomato lycopene extract (TLE) on intestinal inflammation.
The study included mice lipopolysaccharide (LPS)-induced innate signaling and experimental colitis fed a diet containing 0.5 and 2% TLE or isoflavone free control (AIN-76).
According to the tested assays, TLE blocked LPS-induced IkappaBalpha degradation and RelA translocation associated with the onset of colitis by blocking the inhibition of the protein involved in cytokine production.
Futhermore, MIP-2, a small cytokine mRNA accumulation in IEC-18 cells and pro-inflammatory cytokine Interleukin 12 (IL-12) induced by LPS were inhibited by the injection of TLE.
Moreover, application of TLE also increased the expression of anti-inflammatory cytokines IL-6, TNF-alpha, a regulator of inflammation and MCP-1 mRNA associated with macrophage recruitment in the colon of TLE-fed subjects.
The results strongly suggested that tomato extract inhibited the colitis in mice through its modulatory of immune and inflammatory activity.
Taken altogether, tomato may be considered a dietary supplements for the prevention and treatment of colitis, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice by Joo YE1, Karrasch T, Mühlbauer M, Allard B, Narula A, Herfarth HH, Jobin C. (PubMed)
(2) Colitis - Types and Symptoms by Kyle J. Norton
Saturday, June 22, 2019
Soy and Cancers in Japanese
Soybean is the genus Glycine, belonging to the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A6. Soy and cancers in Japan population
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, become progressively worse and damaged other healthy tissues and sometimes spread to other organs in the body via lymph or blood and results may be in death.
Epidemiological studies, linking soy and soy products in reduced risk and treatment have been contradictive(1)(2)(3)(4), but in Japanese population, soy and its products have been found effective in reduced risks of and treatment of cancers, it may be a result of equol-producer status or long term exposure since childhoods. Some researchers suggested that it may be a result of the traditional Japanese diet with high in soy, vegetables, fish.
1. Breast cancer
Breast cancer (malignant breast neoplasm) is cancer started in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) which supply the ducts with milk. There are also rare cases that breast cancer starts in other areas of the breast.
According to the evaluation based on a systematic review of epidemiologic evidence among the Japanese population, there is no associated of intakes of individual soy foods with the risk of breast cancer but evidence supported the biological plausibility of a protective effect of isoflavones on breast cancer risk(5). The study in the testing of oral administration of IF-rich tablet (20 and 40 mg/day) on climacteric women, showed the product not only reduced risk of breast cancer but also improved of bone density, hypertension, and climacteric symptoms, cardiovascular diseases, gynecological problems and possible immune potentiation(6)
Japanese women have a lower incidence of and mortality from breast cancer, compared to Caucasians, it may be a result of large amount intake soy protein and isoflavones, as high dietary intake of phytoestrogens, mainly in the form of soy products, can produce circulating levels of phytoestrogens that are known experimentally to have oestrogenic effects(7).
2. Lung cancer
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers is derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.
Soy intakes are associated to a reduced risk of lung cancer with epidermal growth factor receptor (EGFR) mutations which play substantial roles in genesis and proliferation of non-small-cell lung cancers (NSCLCs), according to the Aichi Cancer Center Research Institute. (8). In Asian populations, not only Japanese, in the review of total of 11 epidemiological studies that consisted of 8 case-control and 3 prospective cohort studies, although consumption of soy food is associated with lower lung cancer risk, intervention studies that use unified measures of soy intake are needed to fully characterize such an association due to different methods used to assess soy consumption across reviewed studies(9).
Indeed, isoflavone intake was associated with a decreased risk of lung cancer in never smokers, but not in current or past smokers, according to a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999, conducted by the National Cancer Center Tokyo Japan(10).
3. Bowel (Colorectal ) Cancer
Bowel cancer also is known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided into 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progresses cancer and in a predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the Research Center for Cancer Prevention and Screening, National Cancer Center in Japan, in investigated association between dietary soy and isoflavone intake and incidence of colorectal cancer in a prospective cohort study of 83,063 Japanese men and women, ages 45 to 74 years, intake of isoflavones, miso soup, and soy food was not associated with colorectal cancer in either men or women. By colorectal cancer subsite, the risk of proximal colon cancer in men decreased with increasing consumption of isoflavones, miso soup, and soy food in Compared with men in the lowest quartiles of isoflavones(11) and high isoflavone intake was associated with reduced risk of CI and MI in Japanese women, especially in postmenopausal women(12).
But for patients with Acromegaly, a syndrome that results when the anterior pituitary gland produces excess growth hormone (GH), the risk of colorectal cancer is increased substantially(13)(14).
4. Gastric cancer
Stomach cancer is defined as a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
According to the National Cancer Center, Goyang, Korea, high level of consumption of non-fermented soy foods, rather than fermented soyfoods, is associated to reducing GC risk, in the reviews of 20 studies assessing the effect of the consumption of fermented soy food on GC risk(15).
4-hydroxy-2 (or 5)-ethyl-5 (or 2)-methyl-3(2H)-furanone (HEMF), a chemical constituent from of Japanese-style fermented soy sauce, reduced hydrogen peroxide concentration in human polymorphonuclear leucocytes stimulated by arachidonic acid or 12-O-tetradecanoylphorbol-13-acetate,through inhibition of carcinogenesis in this system by acting at the post-initiation stage, in female rats(16). The long-term effect of shoyu (Japanese soy sauce), in the rat study, did not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity but with mild gastritis(17).
5. Cancer of Endometrium/Endometrial Cancer
The endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to the menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of the uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
Greater consumption of isoflavone-containing foods is associated with a reduced risk of endometrial cancer in this population of non-hysterectomized postmenopausal women(18).
In support to the above, the University of Hawaii, in the study of Endometrial cancer cases (n = 332) diagnosed between 1985 and 1993 which were identified from the five main ethnic groups in the state (Japanese, Caucasian, Native Hawaiian, Filipino, and Chinese) through the rapid-reporting system of the Hawaii Tumor Registry, showed that plant-based diets low in calories from fat, high in fiber, and rich in legumes (especially soybeans), whole grain foods, vegetables, and fruits reduce the risk of endometrial cancer(20). According to the National Cancer Center, Tokyo, Japan, in the study of Forty-nine thousand one hundred and twenty-one women of age 45-74 years who responded to a 5-year follow-up survey, researchers found that there was no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk(19).
6. Cervical Cancer
The cervix is the lower part of the uterus that opens at the top of the vagina. The cervix acts a transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus. Cervical cancer is malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.
According to the study by, there was a marginally significant inverse association between CIN3 and tofu and green leafy vegetables among Japanese women(21).
7. Prostate cancer
See The Science of Soy - The East Viewpoints: Part A3 - Soy and Prostate Cancer in Japanese Men
8. Thyroid Cancer
The thyroid is one of the largest endocrine glands found in the neck, below the Adam's Apple with the function of regulating the body use of energy, make of proteins by producing its hormones as a result of the stimulation of thyroid-stimulating hormone (TSH) produced by the anterior pituitary.
Thyroid cancer is defined as a condition in which the cells in the thyroid gland have become cancerous.
According to the National Institute of Health Sciences, Tokyo, Japan, in the evaluation of the proliferating cell nuclear antigen labeling indices elevated in the ID diet(iodine-deficient diet) Female F344 rat groups suggest that isoflavones may not be involved in the mechanisms underlying the synergistic goitrogenic effect of soybean with iodine deficiency(22) but the study by showed the positive effect of dietary defatted soybean in synergistically stimulated the growth of rat thyroid with iodine deficiency, partly through a pituitary-dependent pathway(23). No study was found in the search of the keyword - soy and thyroid cancer in the Japanese population" in PubMed).
Taken altogether, Soy and its by-products may be an association to reduce risk and for treating certain cancers in the Japanese population, including breast, lung, bowel, gastric, prostate, endometrial, cervical cancers, etc. Due to the lack of qualities of the studies found in PubMed, further study may be necessary to improve its validation even in the Japanese population.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A6. Soy and cancers in Japan population
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, become progressively worse and damaged other healthy tissues and sometimes spread to other organs in the body via lymph or blood and results may be in death.
Epidemiological studies, linking soy and soy products in reduced risk and treatment have been contradictive(1)(2)(3)(4), but in Japanese population, soy and its products have been found effective in reduced risks of and treatment of cancers, it may be a result of equol-producer status or long term exposure since childhoods. Some researchers suggested that it may be a result of the traditional Japanese diet with high in soy, vegetables, fish.
1. Breast cancer
Breast cancer (malignant breast neoplasm) is cancer started in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) which supply the ducts with milk. There are also rare cases that breast cancer starts in other areas of the breast.
According to the evaluation based on a systematic review of epidemiologic evidence among the Japanese population, there is no associated of intakes of individual soy foods with the risk of breast cancer but evidence supported the biological plausibility of a protective effect of isoflavones on breast cancer risk(5). The study in the testing of oral administration of IF-rich tablet (20 and 40 mg/day) on climacteric women, showed the product not only reduced risk of breast cancer but also improved of bone density, hypertension, and climacteric symptoms, cardiovascular diseases, gynecological problems and possible immune potentiation(6)
Japanese women have a lower incidence of and mortality from breast cancer, compared to Caucasians, it may be a result of large amount intake soy protein and isoflavones, as high dietary intake of phytoestrogens, mainly in the form of soy products, can produce circulating levels of phytoestrogens that are known experimentally to have oestrogenic effects(7).
2. Lung cancer
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers is derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.
Soy intakes are associated to a reduced risk of lung cancer with epidermal growth factor receptor (EGFR) mutations which play substantial roles in genesis and proliferation of non-small-cell lung cancers (NSCLCs), according to the Aichi Cancer Center Research Institute. (8). In Asian populations, not only Japanese, in the review of total of 11 epidemiological studies that consisted of 8 case-control and 3 prospective cohort studies, although consumption of soy food is associated with lower lung cancer risk, intervention studies that use unified measures of soy intake are needed to fully characterize such an association due to different methods used to assess soy consumption across reviewed studies(9).
Indeed, isoflavone intake was associated with a decreased risk of lung cancer in never smokers, but not in current or past smokers, according to a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999, conducted by the National Cancer Center Tokyo Japan(10).
3. Bowel (Colorectal ) Cancer
Bowel cancer also is known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided into 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progresses cancer and in a predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the Research Center for Cancer Prevention and Screening, National Cancer Center in Japan, in investigated association between dietary soy and isoflavone intake and incidence of colorectal cancer in a prospective cohort study of 83,063 Japanese men and women, ages 45 to 74 years, intake of isoflavones, miso soup, and soy food was not associated with colorectal cancer in either men or women. By colorectal cancer subsite, the risk of proximal colon cancer in men decreased with increasing consumption of isoflavones, miso soup, and soy food in Compared with men in the lowest quartiles of isoflavones(11) and high isoflavone intake was associated with reduced risk of CI and MI in Japanese women, especially in postmenopausal women(12).
But for patients with Acromegaly, a syndrome that results when the anterior pituitary gland produces excess growth hormone (GH), the risk of colorectal cancer is increased substantially(13)(14).
4. Gastric cancer
Stomach cancer is defined as a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
According to the National Cancer Center, Goyang, Korea, high level of consumption of non-fermented soy foods, rather than fermented soyfoods, is associated to reducing GC risk, in the reviews of 20 studies assessing the effect of the consumption of fermented soy food on GC risk(15).
4-hydroxy-2 (or 5)-ethyl-5 (or 2)-methyl-3(2H)-furanone (HEMF), a chemical constituent from of Japanese-style fermented soy sauce, reduced hydrogen peroxide concentration in human polymorphonuclear leucocytes stimulated by arachidonic acid or 12-O-tetradecanoylphorbol-13-acetate,through inhibition of carcinogenesis in this system by acting at the post-initiation stage, in female rats(16). The long-term effect of shoyu (Japanese soy sauce), in the rat study, did not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity but with mild gastritis(17).
5. Cancer of Endometrium/Endometrial Cancer
The endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to the menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of the uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
Greater consumption of isoflavone-containing foods is associated with a reduced risk of endometrial cancer in this population of non-hysterectomized postmenopausal women(18).
In support to the above, the University of Hawaii, in the study of Endometrial cancer cases (n = 332) diagnosed between 1985 and 1993 which were identified from the five main ethnic groups in the state (Japanese, Caucasian, Native Hawaiian, Filipino, and Chinese) through the rapid-reporting system of the Hawaii Tumor Registry, showed that plant-based diets low in calories from fat, high in fiber, and rich in legumes (especially soybeans), whole grain foods, vegetables, and fruits reduce the risk of endometrial cancer(20). According to the National Cancer Center, Tokyo, Japan, in the study of Forty-nine thousand one hundred and twenty-one women of age 45-74 years who responded to a 5-year follow-up survey, researchers found that there was no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk(19).
6. Cervical Cancer
The cervix is the lower part of the uterus that opens at the top of the vagina. The cervix acts a transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus. Cervical cancer is malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.
According to the study by, there was a marginally significant inverse association between CIN3 and tofu and green leafy vegetables among Japanese women(21).
7. Prostate cancer
See The Science of Soy - The East Viewpoints: Part A3 - Soy and Prostate Cancer in Japanese Men
8. Thyroid Cancer
The thyroid is one of the largest endocrine glands found in the neck, below the Adam's Apple with the function of regulating the body use of energy, make of proteins by producing its hormones as a result of the stimulation of thyroid-stimulating hormone (TSH) produced by the anterior pituitary.
Thyroid cancer is defined as a condition in which the cells in the thyroid gland have become cancerous.
According to the National Institute of Health Sciences, Tokyo, Japan, in the evaluation of the proliferating cell nuclear antigen labeling indices elevated in the ID diet(iodine-deficient diet) Female F344 rat groups suggest that isoflavones may not be involved in the mechanisms underlying the synergistic goitrogenic effect of soybean with iodine deficiency(22) but the study by showed the positive effect of dietary defatted soybean in synergistically stimulated the growth of rat thyroid with iodine deficiency, partly through a pituitary-dependent pathway(23). No study was found in the search of the keyword - soy and thyroid cancer in the Japanese population" in PubMed).
Taken altogether, Soy and its by-products may be an association to reduce risk and for treating certain cancers in the Japanese population, including breast, lung, bowel, gastric, prostate, endometrial, cervical cancers, etc. Due to the lack of qualities of the studies found in PubMed, further study may be necessary to improve its validation even in the Japanese population.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model by Andrade JE1, Ju YH, Baker C, Doerge DR, HelferichWG.(PubMed)
(2) Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations by Ju YH1, Allred KF, Allred CD, Helferich WG.(PubMed)
(3) Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth by Gaete L1, Tchernitchin AN, Bustamante R, Villena J, Lemus I, Gidekel M, Cabrera G, Astorga P.(PubMed)
(4) The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein by Pabona JM1, Dave B, Su Y, Montales MT, de Lumen BO, de Mejia EG, Rahal OM, Simmen RC.(PubMed)
(5) Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population by Nagata C1, Mizoue T, Tanaka K, Tsuji I, Tamakoshi A, Matsuo K, Wakai K, Inoue M, Tsugane S, Sasazuki S; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan(PubMed)
(6) Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation by Watanabe S1, Uesugi S, Kikuchi Y.(PubMed)
(7) Phytoestrogens and breast cancer--promoters or protectors? by Rice S1, Whitehead SA.(PubMed)
(8) Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese by Matsuo K1, Hiraki A, Ito H, Kosaka T, Suzuki T, Hirose K, Wakai K, Yatabe Y, Mitsudomi T, Tajima K.(PubMed)
(9) Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies by Yang WS1, Va P, Wong MY, Zhang HL, Xiang YB.(PubMed)
(10) Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan by Shimazu T1, Inoue M, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S; Japan Public Health Center-based Prospective Study Group.(PubMed)
(11) Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study by Akhter M1, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S; Japan Public Health Center-Based Prospective Study Group(PubMed)
(12) Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I by Kokubo Y1, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S; JPHC Study Group.(PubMed)
(13) The prevalence and associated factors of colorectal neoplasms in acromegaly: a single center based study by Yamamoto M1, Fukuoka H, Iguchi G, Matsumoto R, Takahashi M, Nishizawa H, Suda K, Bando H, Takahashi Y.(PubMed)
(14) Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels by Matano Y1, Okada T, Suzuki A, Yoneda T, Takeda Y, Mabuchi H(PubMed)
(15) Fermented and non-fermented soy food consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies by Kim J1, Kang M, Lee JS, Inoue M, Sasazuki S, Tsugane S.(PubMed)
(16) Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia and reduction of H2O2 concentration in human polymorphonuclear leucocytes by flavour components of Japanese-style fermented soy sauce by Kataoka S1, Liu W, Albright K, Storkson J, Pariza M.(PubMed)
(17) Long-term effect of shoyu (Japanese soy sauce) on the gastricmucosa of the rat by MacDonald WC, Dueck JW.(PubMed)
(18) Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study by Ollberding NJ1, Lim U, Wilkens LR, Setiawan VW, Shvetsov YB, Henderson BE, Kolonel LN, Goodman MT.(PubMed)
(19) Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study by Budhathoki S1, Iwasaki M, Sawada N, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S; JPHC Study Group(PubMed)
(20) Association of soy and fiber consumption with the risk of endometrial cancer by Goodman MT1, Wilkens LR, Hankin JH, Lyu LC, Wu AH, Kolonel LN.(PubMed)
(21) Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women by Hosono S1, Matsuo K, Kajiyama H, Hirose K, Suzuki T, Kawase T, Kidokoro K, Nakanishi T, Hamajima N, Kikkawa F, Tajima K, Tanaka H.(PubMed)
(22) Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet by Son HY1, Nishikawa A, Ikeda T, Imazawa T, Kimura S, Hirose M.(PubMed)
(23) Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia by Ikeda T1, Nishikawa A, Imazawa T, Kimura S, Hirose M.(PubMed)
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model by Andrade JE1, Ju YH, Baker C, Doerge DR, HelferichWG.(PubMed)
(2) Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations by Ju YH1, Allred KF, Allred CD, Helferich WG.(PubMed)
(3) Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth by Gaete L1, Tchernitchin AN, Bustamante R, Villena J, Lemus I, Gidekel M, Cabrera G, Astorga P.(PubMed)
(4) The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein by Pabona JM1, Dave B, Su Y, Montales MT, de Lumen BO, de Mejia EG, Rahal OM, Simmen RC.(PubMed)
(5) Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population by Nagata C1, Mizoue T, Tanaka K, Tsuji I, Tamakoshi A, Matsuo K, Wakai K, Inoue M, Tsugane S, Sasazuki S; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan(PubMed)
(6) Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation by Watanabe S1, Uesugi S, Kikuchi Y.(PubMed)
(7) Phytoestrogens and breast cancer--promoters or protectors? by Rice S1, Whitehead SA.(PubMed)
(8) Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese by Matsuo K1, Hiraki A, Ito H, Kosaka T, Suzuki T, Hirose K, Wakai K, Yatabe Y, Mitsudomi T, Tajima K.(PubMed)
(9) Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies by Yang WS1, Va P, Wong MY, Zhang HL, Xiang YB.(PubMed)
(10) Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan by Shimazu T1, Inoue M, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S; Japan Public Health Center-based Prospective Study Group.(PubMed)
(11) Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study by Akhter M1, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S; Japan Public Health Center-Based Prospective Study Group(PubMed)
(12) Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I by Kokubo Y1, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S; JPHC Study Group.(PubMed)
(13) The prevalence and associated factors of colorectal neoplasms in acromegaly: a single center based study by Yamamoto M1, Fukuoka H, Iguchi G, Matsumoto R, Takahashi M, Nishizawa H, Suda K, Bando H, Takahashi Y.(PubMed)
(14) Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels by Matano Y1, Okada T, Suzuki A, Yoneda T, Takeda Y, Mabuchi H(PubMed)
(15) Fermented and non-fermented soy food consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies by Kim J1, Kang M, Lee JS, Inoue M, Sasazuki S, Tsugane S.(PubMed)
(16) Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia and reduction of H2O2 concentration in human polymorphonuclear leucocytes by flavour components of Japanese-style fermented soy sauce by Kataoka S1, Liu W, Albright K, Storkson J, Pariza M.(PubMed)
(17) Long-term effect of shoyu (Japanese soy sauce) on the gastricmucosa of the rat by MacDonald WC, Dueck JW.(PubMed)
(18) Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study by Ollberding NJ1, Lim U, Wilkens LR, Setiawan VW, Shvetsov YB, Henderson BE, Kolonel LN, Goodman MT.(PubMed)
(19) Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study by Budhathoki S1, Iwasaki M, Sawada N, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S; JPHC Study Group(PubMed)
(20) Association of soy and fiber consumption with the risk of endometrial cancer by Goodman MT1, Wilkens LR, Hankin JH, Lyu LC, Wu AH, Kolonel LN.(PubMed)
(21) Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women by Hosono S1, Matsuo K, Kajiyama H, Hirose K, Suzuki T, Kawase T, Kidokoro K, Nakanishi T, Hamajima N, Kikkawa F, Tajima K, Tanaka H.(PubMed)
(22) Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet by Son HY1, Nishikawa A, Ikeda T, Imazawa T, Kimura S, Hirose M.(PubMed)
(23) Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia by Ikeda T1, Nishikawa A, Imazawa T, Kimura S, Hirose M.(PubMed)
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