"Let foods be your medicine and let medicines be your food", using foods as medication has been a dream of many scholars and scientists over past many centuries. In order to achieve these, consumption of whole food medicine must accompany with moderated exercise, change of diet and life style.
Evidence from laboratory studies opinionated, regular drinking of green tea improved bone health and reduced risk of osteoporosis and fractures.
Bone health is measured by bone mineral density which has an direct influence in risk of osteoporosis and fractures.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine ,or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But adding a slice of ginger will benign the problem.
According to Texas Tech University Health Sciences Center, green tea lovers have a reduced risk of lower bone mineral density due to its bioactive components with bone-protective properties.
The study also found that, regular green tea drinking promotes bone health in bone mineral loss menopausal women through increased bone mass, thus reducing risk of osteoporosis, a common disease in aging population.
Furthermore, intake of green also protected early onset of bone mineral loss in obese subjects.
Other study conducted by the same group of researchers also stated, the bone density protective effect of green tea may involve the bioactive components' effects in decreased risk of fracture by supporting osteoblastic activities while suppressing osteoclastic activities as well as attenuating oxidative stress in promoted healthy levels of bone mineral density.
In postmenopausal osteopenic women study, green tea with optimized dose of polyphenols showed an enhanced osteoprotective efficacy in improved bone mass, microarchitecture integrity, and bone strength observed through the advanced imaging technology.
Dr, Shen CL, the lead author in the studies said, " Tea polyphenols enhance osteoblastogenesis and suppress osteoclastogenesis in vitro" and "Animal studies reveal that intake of tea polyphenols have pronounced positive effects on bone as shown by higher bonemass and trabecular bone volume, number, and thickness and lower trabecular separation via increasing boneformation and inhibition of bone resorption, resulting in greater bone strength".
Promisingly, in a total study of 171 postmenopausal osteopenic women to compare the efficacy of green tea polyphenols (GTP) supplement and/or Tai Chi in risk of osteoporosis, randomly assigned to four groups: (1) placebo (500 mg starch/day), (2) GTP (500 mg GTP/day), (3) placebo + TC (placebo plus TC training at 60 min/session, three sessions/week), and (4) GTP + TC (GTP plus TC training).for 6 months, intake of green and tai chi exercise groups increased bone-specific alkaline phosphatase(bone protective glycoprotein found on the surface of osteoblasts) and improved BAP/(tartrate-resistant acid phosphatase, osteoclast increased risk of bone turnover)/TRAP ratio.
Additionally, group received also green tea showed a significant improved muscle strength in postmenopausal women with osteopenia.
Taking together, green tea may be served as functional food to protect bone mineral density in all people with/ without risk of osteoporosis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS.(PubMed)
(2) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS.(PubMed)
(3) Tea and bone health: steps forward in translational nutrition by Shen CL1, Chyu MC, Wang JS.(PubMed)
(4) Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial by Shen CL1, Chyu MC, Yeh JK, Zhang Y, Pence BC, Felton CK, Brismée JM, Arjmandi BH, Doctolero S, Wang JS.(PubMed)
Thursday, June 27, 2019
Soy and the risk of cerebral infarction (CI) and myocardial infarction (MI) in Japan population
Soy foods, including tofu, have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in the Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes, and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with a large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experiencing symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in an older adult in Japan.(b)
The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over the past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidence could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.
Today, the promotion of soy no longer exists, it may be results of the discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce the risk of certain mammary cancers and infertility. The publication of the result has drawn many criticisms. According to Thomas Badger, director, and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a). Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by the University of Goettingen may be interesting, as researchers said" Most importantly, there is a dispute as to whether isoflavones derived from soy or red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancer-preventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".
Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b)
A.1. Soy and the risk of cerebral infarction (CI) and myocardial infarction (MI) in Japan population
The searching of the Keywords in PubMed, soy and heart diseases and stroke in Japan found 3 studies, all showed the positive effect of soy in reduced risk heart disease and stroke.
Cerebral infarction (CI) is defined as a type of ischemic stroke due to blockage in the blood vessels supplying blood to the brain.
Myocardial infarction (MI) is also known as a heart attack. It is defined as a condition of blood stops flowing properly to part of the heart as a result of not receiving enough oxygen.
According to the National Cardiovascular Center, Japan, the studied 40,462 Japanese (40 to 59 years old, without cardiovascular disease or cancer at baseline), yields interest results.
People who consume more soy are less likely to be current smokers but more likely to be hypertensive, with men are more likely to have diabetes mellitus. The frequency of soy intake was positively related to a daily intake of rice, vegetables, fruits, fish, potassium, calcium, carbohydrate, polyunsaturated fatty acid, saturated fatty acid, fiber, and isoflavones for both sexes.
The study started in 1990 with a food-frequency questionnaire included 44 foods with 3 questions to assess soy, bean, and miso consumption. The 1995 follow-up questionnaire covered 147 foods with 8 questions on soy products.
The result is astonishing, during a follow-up period that averaged 12.5 years, 1230 strokes were documented, of which 1137 were confirmed through imaging or autopsy. even through high isoflavone intake was associated with reduced risk of CI and MI in middle-aged Japanese subjects, but not in men and dietary isoflavones and may be beneficial to postmenopausal women for the prevention of ischemic CVD(2). Intake of miso soup showed to reduce risk of hypertension but did not contribute to ischemic CVD mortality in neither men or women.
Strong evidence of epidemiological studies from the East and West have shown that hyperlipidemia is a major risk factor in contributing to heart diseases, notably on intermediate endpoints(3)(4). Soy foods intake has been known to contain lowering cholesterol and blood pressure effects. According to the Veterans Affairs Medical Center, daily soy protein showed significantly decreased serum concentrations of total cholesterol, LDL cholesterol, and triglycerides without significantly affecting serum HDL cholesterol concentrations.(4). But the study suggested that the mechanism of reduced risk of cerebral infarction (CI) and myocardial infarction (MI) for postmenopausal Japanese women may not be through reduction of lipid profile but through exposure to a large number of isoflavones, which act as estrogen agonist because estrogen receptors are not occupied with plasma estradiol in postmenopausal women.
In case of hypertension in the subject of study, although the disease has been shown to contribute to the early risk factor for the progression heat disease and stroke(6)(7)(8)(9). Consumption of soy has no effect in reducing risk of the development of cerebral infarction (CI) and myocardial infarction for people with histories of hypertension and diabetes mellitus and medication use for hypercholesterolemia, even soy has shown effectively in reduced high blood pressure(12)
In support to the above, the dietary intervention study targeting female students by using cake containing soybean protein and isoflavone at the Mukogawa Women's University, 4 weeks dietary intake of soy protein found to reduce CHD risk among Japanese female students with a high plasma cholesterol level(10) and Dr. Nagata C. at the Gifu University School of Medicine, Gifu, Japan, in the study of association between soy product intake and mortality from cancer and heart disease in Japan, suggested that soy foods intake showed a preventive role in against stomach cancer and heart disease death(11).
Dr. Yoshihiro Kokubo and the research team also acknowledged the limitation of the study such as ethnic group, measurement errors with nutrient intake or due to it self report, but insisted that nationwide annual health screenings may ease the self-report concern.
They also clarified that the result of the study of dietary intake of isoflavones is not relevant to the association of isoflavone supplement use with ischemic CVD.
Indeed, the effectiveness of soy isoflavone in reduced risk of cerebral infarction (CI) and myocardial infarction, in this case, yields some questions due to its ethnicity.
a. If soy is found to be effective in reducing risk of hypertension and hyperlipidemia, why it does not contribute to the reduce risk of cerebral infarction (CI) and myocardial infarction in men with histories of hypertension and diabetes mellitus and medication use for hypercholesterolemia.
Would the medication be the cause? As epidemiological study insisted on the lowering effect of blood pressure and cholesterol are associated to reduce risk heart disease and stroke.
b. Although soy isoflavone showed effectiveness in reduce risk of cerebral infarction (CI) and myocardial infarction and mortality, would dietary with high in fruit and vegetable also best known for the reduced risk of heart disease and stroke be also taken into account?
c. The effectiveness of the study may only be true for equol producers population as 90% of the subjects' study are equol producers?
d. Would the "Japanese Phenomenon" interfere with the study, as the administration of isoflavone "inexperienced" women at the time of menopause, the phytoestrogens appear to share the same effects as estrogen used in classical preparations for hormone replacement therapy?
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) The Science of Soy: What Do We Really Know? by Julia R. Barrett
(b) Guideline for healthy soy intake(the Unite Soybean board)
(1) Japan, Wikipedia
(1a) Erdman JW Jr. AHA Science Advisory: soy protein and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation. 2000; 102: 2555–2559
(Soy protein and cardiovascular disease)
(1b) van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation. 2005; 111: 465–471(Cardiovascular diseases in women)
(5) Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population by Nagata C1, Mizoue T, Tanaka K, Tsuji I, Tamakoshi A, Matsuo K, Wakai K, Inoue M, Tsugane S, Sasazuki S; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.(PubMed)
(6) Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study by Toi M1, Hirota S, Tomotaki A, Sato N, Hozumi Y, Anan K, Nagashima T, Tokuda Y, Masuda N, Ohsumi S, Ohno S, Takahashi M, Hayashi H, Yamamoto S, Ohashi Y.(PubMed)
(7) Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanesewomen by Tsuji M1, Tamai Y, Wada K, Nakamura K, Hayashi M, Takeda N, Yasuda K, Nagata C.(PubMed)
(8) Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group by Iwasaki M1, Inoue M, Otani T, Sasazuki S, Kurahashi N, Miura T, Yamamoto S, Tsugane S; Japan Public Health Center-based prospective study group.(PubMed)
(9) Isoflavones--safe food additives or dangerous drugs? by Wuttke W1, Jarry H, Seidlová-Wuttke D.(PubMed)
(10) Effect of a soybean product on serum lipid levels in female universitystudents by Takahashi K1, Kamada Y, Hiraoka-Yamamoto J, Mori M, Nagata R, Hashimoto K, Aizawa T, Matsuda K, Kometani T, Ikeda K, Yamori Y.(PubMed)
(11) Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan by Nagata C.(PubMed)
(12) Association of blood pressure with intake of soy products and other food groups in Japanese men and women by Nagata C1, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.(PubMed)
(13) Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland by Sagara M1, Kanda T, NJelekera M, Teramoto T, Armitage L, Birt N, Birt C, Yamori Y.(PubMed)
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in an older adult in Japan.(b)
The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over the past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidence could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.
Today, the promotion of soy no longer exists, it may be results of the discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce the risk of certain mammary cancers and infertility. The publication of the result has drawn many criticisms. According to Thomas Badger, director, and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a). Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.
The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by the University of Goettingen may be interesting, as researchers said" Most importantly, there is a dispute as to whether isoflavones derived from soy or red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancer-preventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".
Soybean is genus Glycine, the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b)
A.1. Soy and the risk of cerebral infarction (CI) and myocardial infarction (MI) in Japan population
The searching of the Keywords in PubMed, soy and heart diseases and stroke in Japan found 3 studies, all showed the positive effect of soy in reduced risk heart disease and stroke.
Cerebral infarction (CI) is defined as a type of ischemic stroke due to blockage in the blood vessels supplying blood to the brain.
Myocardial infarction (MI) is also known as a heart attack. It is defined as a condition of blood stops flowing properly to part of the heart as a result of not receiving enough oxygen.
According to the National Cardiovascular Center, Japan, the studied 40,462 Japanese (40 to 59 years old, without cardiovascular disease or cancer at baseline), yields interest results.
People who consume more soy are less likely to be current smokers but more likely to be hypertensive, with men are more likely to have diabetes mellitus. The frequency of soy intake was positively related to a daily intake of rice, vegetables, fruits, fish, potassium, calcium, carbohydrate, polyunsaturated fatty acid, saturated fatty acid, fiber, and isoflavones for both sexes.
The study started in 1990 with a food-frequency questionnaire included 44 foods with 3 questions to assess soy, bean, and miso consumption. The 1995 follow-up questionnaire covered 147 foods with 8 questions on soy products.
The result is astonishing, during a follow-up period that averaged 12.5 years, 1230 strokes were documented, of which 1137 were confirmed through imaging or autopsy. even through high isoflavone intake was associated with reduced risk of CI and MI in middle-aged Japanese subjects, but not in men and dietary isoflavones and may be beneficial to postmenopausal women for the prevention of ischemic CVD(2). Intake of miso soup showed to reduce risk of hypertension but did not contribute to ischemic CVD mortality in neither men or women.
Strong evidence of epidemiological studies from the East and West have shown that hyperlipidemia is a major risk factor in contributing to heart diseases, notably on intermediate endpoints(3)(4). Soy foods intake has been known to contain lowering cholesterol and blood pressure effects. According to the Veterans Affairs Medical Center, daily soy protein showed significantly decreased serum concentrations of total cholesterol, LDL cholesterol, and triglycerides without significantly affecting serum HDL cholesterol concentrations.(4). But the study suggested that the mechanism of reduced risk of cerebral infarction (CI) and myocardial infarction (MI) for postmenopausal Japanese women may not be through reduction of lipid profile but through exposure to a large number of isoflavones, which act as estrogen agonist because estrogen receptors are not occupied with plasma estradiol in postmenopausal women.
In case of hypertension in the subject of study, although the disease has been shown to contribute to the early risk factor for the progression heat disease and stroke(6)(7)(8)(9). Consumption of soy has no effect in reducing risk of the development of cerebral infarction (CI) and myocardial infarction for people with histories of hypertension and diabetes mellitus and medication use for hypercholesterolemia, even soy has shown effectively in reduced high blood pressure(12)
In support to the above, the dietary intervention study targeting female students by using cake containing soybean protein and isoflavone at the Mukogawa Women's University, 4 weeks dietary intake of soy protein found to reduce CHD risk among Japanese female students with a high plasma cholesterol level(10) and Dr. Nagata C. at the Gifu University School of Medicine, Gifu, Japan, in the study of association between soy product intake and mortality from cancer and heart disease in Japan, suggested that soy foods intake showed a preventive role in against stomach cancer and heart disease death(11).
Dr. Yoshihiro Kokubo and the research team also acknowledged the limitation of the study such as ethnic group, measurement errors with nutrient intake or due to it self report, but insisted that nationwide annual health screenings may ease the self-report concern.
They also clarified that the result of the study of dietary intake of isoflavones is not relevant to the association of isoflavone supplement use with ischemic CVD.
Indeed, the effectiveness of soy isoflavone in reduced risk of cerebral infarction (CI) and myocardial infarction, in this case, yields some questions due to its ethnicity.
a. If soy is found to be effective in reducing risk of hypertension and hyperlipidemia, why it does not contribute to the reduce risk of cerebral infarction (CI) and myocardial infarction in men with histories of hypertension and diabetes mellitus and medication use for hypercholesterolemia.
Would the medication be the cause? As epidemiological study insisted on the lowering effect of blood pressure and cholesterol are associated to reduce risk heart disease and stroke.
b. Although soy isoflavone showed effectiveness in reduce risk of cerebral infarction (CI) and myocardial infarction and mortality, would dietary with high in fruit and vegetable also best known for the reduced risk of heart disease and stroke be also taken into account?
c. The effectiveness of the study may only be true for equol producers population as 90% of the subjects' study are equol producers?
d. Would the "Japanese Phenomenon" interfere with the study, as the administration of isoflavone "inexperienced" women at the time of menopause, the phytoestrogens appear to share the same effects as estrogen used in classical preparations for hormone replacement therapy?
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) The Science of Soy: What Do We Really Know? by Julia R. Barrett
(b) Guideline for healthy soy intake(the Unite Soybean board)
(1) Japan, Wikipedia
(1a) Erdman JW Jr. AHA Science Advisory: soy protein and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation. 2000; 102: 2555–2559
(Soy protein and cardiovascular disease)
(1b) van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation. 2005; 111: 465–471(Cardiovascular diseases in women)
(5) Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population by Nagata C1, Mizoue T, Tanaka K, Tsuji I, Tamakoshi A, Matsuo K, Wakai K, Inoue M, Tsugane S, Sasazuki S; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.(PubMed)
(6) Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study by Toi M1, Hirota S, Tomotaki A, Sato N, Hozumi Y, Anan K, Nagashima T, Tokuda Y, Masuda N, Ohsumi S, Ohno S, Takahashi M, Hayashi H, Yamamoto S, Ohashi Y.(PubMed)
(7) Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanesewomen by Tsuji M1, Tamai Y, Wada K, Nakamura K, Hayashi M, Takeda N, Yasuda K, Nagata C.(PubMed)
(8) Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group by Iwasaki M1, Inoue M, Otani T, Sasazuki S, Kurahashi N, Miura T, Yamamoto S, Tsugane S; Japan Public Health Center-based prospective study group.(PubMed)
(9) Isoflavones--safe food additives or dangerous drugs? by Wuttke W1, Jarry H, Seidlová-Wuttke D.(PubMed)
(10) Effect of a soybean product on serum lipid levels in female universitystudents by Takahashi K1, Kamada Y, Hiraoka-Yamamoto J, Mori M, Nagata R, Hashimoto K, Aizawa T, Matsuda K, Kometani T, Ikeda K, Yamori Y.(PubMed)
(11) Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan by Nagata C.(PubMed)
(12) Association of blood pressure with intake of soy products and other food groups in Japanese men and women by Nagata C1, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.(PubMed)
(13) Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland by Sagara M1, Kanda T, NJelekera M, Teramoto T, Armitage L, Birt N, Birt C, Yamori Y.(PubMed)
Wednesday, June 26, 2019
Bilberry Protects the Arteries Against the Risk of Atherosclerosis in Vivo
Atherosclerosis, one of the major cause of the cardiovascular disease is a medical condition caused by the accumulation of plaque on the arterial wall. Over time, the condition can lead to narrowing the arteries or blocked arteries, leading to reduce oxygenated blood flow to the heart and other parts of the body.
Arteries are blood vessels carried the oxygen-rich blood to the heart before passing them to the tissues and organs.
Plague is made up of fat, cholesterol, calcium, and other substances found in the blood. In other words, cholesterol that cannot be returned to the liver for reuse may have a strong impact to induce plaque accumulation.
People at the early stage of atherosclerosis are asymptomatic. However, over time, the continued buildup of plaque on the arterial wall can cause symptoms of chest pain or angina shortness of breath. fatigue. confusion, due to a blockage or reduce blood flow.
Although there are many risk factors associated with the onset of atherosclerosis, an unhealthy lifestyle, particularly in people who follow the pattern of the Western diet has been found in many patients with the disease.
Dr. Matthias Nahrendorf, the lead scientist wrote, "Diet, exercise, stress, and sleep are receiving attention as environmental modifiers of chronic inflammatory diseases, including atherosclerosis, the culprit condition of myocardial infarction and stroke".
And, "Accumulating data indicate that psychosocial stress and a high-fat, high-cholesterol diet aggravate the cardiovascular disease, whereas regular physical activity and healthy sleeping habits help prevent it".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding a potential compound for the treatment of atherosclerosis researchers evaluated a nutritional supplementation with a bilberry anthocyanin-rich extract (BE) in the atherosclerotic lesion development in apolipoprotein E-deficient (apoE⁻/⁻) mice.
On the early stage of atherosclerosis development in tested mice, BE significantly improved hypercholesterolemia associated with plaques built-up without affecting the plasmatic antioxidant status.
According to the nutrigenomic analysis, BE modulated the expression of the gene involved in different cellular processes such as oxidative stress, inflammation, transendothelial migration, and angiogenesis, that lead to atherosclerosis development/protection.
In other words, BE enhanced the mechanisms involved in the preventive action of bilberry anthocyanin-rich extract against atherosclerosis.
On the development of atherosclerosis in apolipoprotein E-deficient mice (apo E(-/-)). Apo E(-/-) mice, researchers compared the efficacy of two bilberry extracts, one rich in anthocyanins extracted from untreated bilberries (BE) and a second one extracted from yeast-fermented bilberries (FBE).
According to the 16 weeks a diet supplemented with 0.02% of either BE or FBE, both bilberry extracts led to significant inhibition of plaque development, without affecting the levels of oxidative stress parameters or lipid profiles.
These results strongly suggested that bilberry extract inhibited plaque development through other unknown mechanisms.
By comparative tests, fermentation generates new bioactive compounds FBE are more effective in attenuating progression of the atherosclerotic lesions compared to those of BE.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of atherosclerosis, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice by Mauray A1, Felgines C, Morand C, Mazur A, Scalbert A, Milenkovic D. (PubMed)
(2) Atheroprotective effects of bilberry extracts in apo E-deficient mice by Mauray A1, Milenkovic D, Besson C, Caccia N, Morand C, Michel F, Mazur A, Scalbert A, Felgines C. (PubMed)
(3) Lifestyle effects on hematopoiesis and atherosclerosis by Matthias Nahrendorf and Filip K. Swirski. (PMC)
Arteries are blood vessels carried the oxygen-rich blood to the heart before passing them to the tissues and organs.
Plague is made up of fat, cholesterol, calcium, and other substances found in the blood. In other words, cholesterol that cannot be returned to the liver for reuse may have a strong impact to induce plaque accumulation.
People at the early stage of atherosclerosis are asymptomatic. However, over time, the continued buildup of plaque on the arterial wall can cause symptoms of chest pain or angina shortness of breath. fatigue. confusion, due to a blockage or reduce blood flow.
Although there are many risk factors associated with the onset of atherosclerosis, an unhealthy lifestyle, particularly in people who follow the pattern of the Western diet has been found in many patients with the disease.
Dr. Matthias Nahrendorf, the lead scientist wrote, "Diet, exercise, stress, and sleep are receiving attention as environmental modifiers of chronic inflammatory diseases, including atherosclerosis, the culprit condition of myocardial infarction and stroke".
And, "Accumulating data indicate that psychosocial stress and a high-fat, high-cholesterol diet aggravate the cardiovascular disease, whereas regular physical activity and healthy sleeping habits help prevent it".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding a potential compound for the treatment of atherosclerosis researchers evaluated a nutritional supplementation with a bilberry anthocyanin-rich extract (BE) in the atherosclerotic lesion development in apolipoprotein E-deficient (apoE⁻/⁻) mice.
On the early stage of atherosclerosis development in tested mice, BE significantly improved hypercholesterolemia associated with plaques built-up without affecting the plasmatic antioxidant status.
According to the nutrigenomic analysis, BE modulated the expression of the gene involved in different cellular processes such as oxidative stress, inflammation, transendothelial migration, and angiogenesis, that lead to atherosclerosis development/protection.
In other words, BE enhanced the mechanisms involved in the preventive action of bilberry anthocyanin-rich extract against atherosclerosis.
On the development of atherosclerosis in apolipoprotein E-deficient mice (apo E(-/-)). Apo E(-/-) mice, researchers compared the efficacy of two bilberry extracts, one rich in anthocyanins extracted from untreated bilberries (BE) and a second one extracted from yeast-fermented bilberries (FBE).
According to the 16 weeks a diet supplemented with 0.02% of either BE or FBE, both bilberry extracts led to significant inhibition of plaque development, without affecting the levels of oxidative stress parameters or lipid profiles.
These results strongly suggested that bilberry extract inhibited plaque development through other unknown mechanisms.
By comparative tests, fermentation generates new bioactive compounds FBE are more effective in attenuating progression of the atherosclerotic lesions compared to those of BE.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of atherosclerosis, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice by Mauray A1, Felgines C, Morand C, Mazur A, Scalbert A, Milenkovic D. (PubMed)
(2) Atheroprotective effects of bilberry extracts in apo E-deficient mice by Mauray A1, Milenkovic D, Besson C, Caccia N, Morand C, Michel F, Mazur A, Scalbert A, Felgines C. (PubMed)
(3) Lifestyle effects on hematopoiesis and atherosclerosis by Matthias Nahrendorf and Filip K. Swirski. (PMC)
Green Tea, the Best Functional Food for Oral Health
Green tea is found to consist a potential effect in the promotion of oral health against bacterial-induced tooth decay or cavities, a renowned institute suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including lack of energy, weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
According to the Technion-Israel Institute of Technology, Polyphenols including epigallocatechin 3 gallate (EGCG) isolated from green tea ameliorated oral cavity oxidative stress and inflammation, cigarette smoking and cigarettes' deleterious compounds nicotine and acrolein.
Dr. Narotzki B, the lead author of the study said, " Generally, green tea defends healthy cells from malignant transformation and locally has the ability to induce apoptosis in oral cancer cells. All together, there is an increasing interest in the health benefits of green tea in the field of oral health".
In the review of beneficial effects of green tea on oral disease, researchers found that green tea not only reduced the bacterial activity in the oral cavity in expression of the aforementioned oral afflictions but also attenuated risk of oral cancer through the antioxidant activities.
EGCG, in Solobacterium moorei, a volatile sulfide compound (VSC)-producing Gram-positive anaerobic bacterium study, displayed a significant effect in inhibited the growth of S. moorei, with MIC values of 500 and 250 μg/ml resulting in reduced the adherence of S. moorei to oral epithelial cells.
The study also suggested, the efficacy of green tea extract and EGCG protected oral health by inhibited the progression of Solobacterium moorei probably through the ameliorated S. moorei's β-galactosidase activity in production of volatile sulfide compound (VSC) in doses dependent manner.
Green tea with abundant natural compounds may be the next generation of whole food used a therapeutic supplement in promoted oral healthcare.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea: a promising natural product in oral health by Narotzki B1, Reznick AZ, Aizenbud D, Levy Y.(PubMed)
(2) Green Tea (Camellia Sinensis): Chemistry and Oral Health by Khurshid Z1, Zafar MS2, Zohaib S3, Najeeb S4, Naseem M5.(PubMed)
(3) Green tea extract and its major constituent epigallocatechin-3-gallate inhibit growth and halitosis-related properties of Solobacterium moorei by Morin MP1, Bedran TB2, Fournier-Larente J3, Haas B4, Azelmat J5, Grenier D6.(PubMed)
Tuesday, June 25, 2019
Soy and Obesity in Japanese
Soybean is the genus Glycine, belonging to the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A4. Soy and Obesity in Japanese
Soy foods intake is well known for it estrogenic effects because it binds the estrogen receptor with relatively high affinity, but effects induced risk of obesity are inconclusive in the West(1)(2)(3).
It may be results of most Westerner are nonequol producers(4)(5). Some researchers suggested that the prevalence of obesity in the West may be a result of a typical American diet with high in saturated and trans-fat and less in fruits and vegetables. Other blamed the epidemic obesity is a result of an economic environment which make healthy foods more expensive than junks and suggested of taxes on foods with the low nutritional value could nudge behavior toward healthier diets, as could subsidies/discounts for healthier(8). According to a report on NBC by Melissa Dhal, just 10.8 percent of Asians in America are considered obese, a slim percentage when compared with the 33 percent of whites, 42 percent of Hispanics and 48 percent of blacks with a BMI of 30 or higher(7).
In fact, the traditional Japanese diet with a high amount of soy products is associated with a lower BMI in adulthood(9).
According to the Dr. Ma J and the research team, the early exposure to a high-fat diet diminished the abundance of non-pathogenic Campylobacter in the juvenile gut of that may enhance the risk of obesity(10). In fact, DR. Sakata T. said that a very-low-calorie conventional Japanese diet of 370 kcal/day has been shown to be useful for weight reduction and its long-term maintenance(11). and dietary content and food patterns used in management among Japanese patients with type 2 diabetes are quite close to those reported as suitable for prevention of obesity, type 2 diabetes, cardiovascular disease, and total mortality in Europe and America, according to the study of 1,516 patients with type 2 diabetes aged 40-70 years from outpatient clinics in 59 university and general hospitals(12). Regarded to diet habit of the West and Japanese working women, the proportion of eating problems is low in comparison with Western adult populations(15).
Study of Occupational Class Differences in Body Mass Index and Weight Gain in Japan and Finland may provide us with interesting result "BMI was higher at baseline and BMI gain was more rapid in Finland than in Japan, it may be results of clear socioeconomic gradients in obesity in Finland compared to the Japanese environment is less obesogenic than the Finnish environment, or factors such as easy access to fast-food restaurants and limited possibilities for physical exercise are suggested characteristics of an obesogenic environment or due to the Japanese diet has traditionally been very healthy, with high consumption of vegetables, soy protein, and fish, with the general nutritional status of the Japanese population is still healthier than that in many Western countries" (13).
Unfortunately, due to the influence of the West, many Japanese have abandoned the traditional Japanese diet but opted for a quick, high-fat diet with lots of junk foods. According to the Kagawa Nutrition University, Japanese traditional and Western, were all independently and significantly related to the risk of obesity even among a relatively lean young Japanese female population(14).
Other study suggested that adapting maternal Western-style diet consumption may lead to increased susceptibility to type 2 diabetes in the offspring(16), and Western diet increased the risk for atherosclerosis and promoted the progression of preclinical atherosclerosis, in correspondence with the extent of westernization(17). As undergoing rapid "Westernization," , change in Japanese dietary patterns continued, with high intake of butter & margarine, cheese, bread and ham & sausage, etc.(18), the Westernized chronic illness may rise to a level currently found in the "Western" countries in the coming few decades, including diverticular disease, mammary cancers(19)(20).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats by Strakovsky RS1, Lezmi S, Flaws JA, Schantz SL, Pan YX, Helferich WG.(PubMed)
(2) Arginine, soy isoflavone and hydroxypropylmethylcellulose have protective effects against obesity in broiler breeder hens fed on high-energy diets by Khalaji S1, Zaghari M, Ganjkhanloo M, Ghaziani F.(PubMed)
(3) Effects of voluntary running and soy supplementation on diet-induced metabolic disturbance and inflammation in mice by Yan L1, Graef GL, Claycombe KJ, Johnson LK.(PubMed)
(4) Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status by Usui T1, Tochiya M, Sasaki Y, Muranaka K, Yamakage H, Himeno A, Shimatsu A, Inaguma A, Ueno T, Uchiyama S, Satoh-Asahara N.(PubMed)
(5) Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein by Frankenfeld CL1, Atkinson C2, Wähälä K3, Lampe JW4.(PubMed)
(6) Family-focused physical activity, diet and obesity interventions in African-American girls: a systematic review by Barr-Anderson DJ1, Adams-Wynn AW, DiSantis KI, Kumanyika S.(PubMed)
(7). What's actually behind the low Asian-American obesity rate? by Melissa Dahl
(8) Obesity and economic environments by Sturm R1, An R.(PubMed)
(9) Soy intake is related to a lower body mass index in adult women by Maskarinec G1, Aylward AG, Erber E, Takata Y, Kolonel LN.(PubMed)
(10) High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model by Ma J1, Prince AL2, Bader D3, Hu M4, Ganu R4, Baquero K5, Blundell P5, Alan Harris R6, Frias AE5, Grove KL5, Aagaard KM(PubMed)
(11) A very-low-calorie conventional Japanese diet: its implications for prevention of obesity by Sakata T.(PubMed)
(12) Dietary intake in Japanese patients with type 2 diabetes: Analysis from Japan Diabetes Complications Study by Horikawa C1, Yoshimura Y2, Kamada C2, Tanaka S3, Tanaka S4, Takahashi A5, Hanyu O6, Araki A7, Ito H7, Tanaka A8, Ohashi Y5, Akanuma Y9, Yamada N10, Sone H6.(PubMed)
(13) ccupational Class Differences in Body Mass Index and Weight Gain in Japan and Finland
Karri Silventoinen,1 Takashi Tatsuse,2 Pekka Martikainen,1 Ossi Rahkonen,3 Eero Lahelma,3 Michikazu Sekine,2 and Tea Lallukka3,4by PubMed)
(14) Three major dietary patterns are all independently related to the risk of obesity among 3760 Japanese women aged 18-20 years by Okubo H1, Sasaki S, Murakami K, Kim MK, Takahashi Y, Hosoi Y, Itabashi M; Freshmen in Dietetic Courses Study II group.(PubMed)
(15) Eating problems and related weight control behaviour in adult Japanese women by Nakamura K1, Hoshino Y, Watanabe A, Honda K, Niwa S, Yamamoto M.(PubMed)
(16) Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese Macaque model by Pound LD1, Comstock SM2, Grove KL2.(PubMed)
(17) Influence of the extent of westernization of lifestyle on the progression of preclinical atherosclerosis in Japanese subjects by Egusa G1, Watanabe H, Ohshita K, Fujikawa R, Yamane K, Okubo M, Kohno N.(PubMed)
(18) Dietary factors related to higher plasma fibrinogen levels of Japanese-americans in hawaii compared with Japanese in Japan by Miura K1, Nakagawa H, Ueshima H, Okayama A, Saitoh S, Curb JD, Rodriguez BL, Sakata K, Okuda N, Yoshita K, Stamler J; INTERMAP Research Group; INTERLIPID Research Group.(PubMed)
(19) Changes in dietary fiber intake among Japanese in the 20th century: a relationship to the prevalence of diverticular disease by Ohi G, Minowa K, Oyama T, Nagahashi M, Yamazaki N, Yamamoto S, Nagasako K, Hayakawa K, Kimura K, Mori B.(PubMed).
(20) Relationship between westernization of dietary habits and mortality from breast and ovarian cancers in Japan. Kato I, Tominaga S, Kuroishi T.(PubMed)
Herbal Turmeric Reduces the Risk of Diabetic Nephropathy in Diabetes, According to Researchers
Diabetic nephropathy (diabetic kidney disease) is a complication of kidney damage caused by diabetes.
Long-term unmanaged hyperglycemia can damage the part of the kidneys thus reducing the kidney function in filter waste from the blood filters, leading to 'leaky' syndrome that allows protein into your urine.
Diabetic nephropathy is the 3 stage of kidney change in patients with diabetes. In this stage, patients may experience symptoms of abnormally elevated urinary albumin excretion, compared to the 15 and 300 μg/min in the baseline situation.
The progression of diabetic nephropathy that leads to an increased rate in albumin excretion is higher in patients with increased blood pressure.
More importantly, if high blood pressure is left untreated, diabetic nephropathy can induce persistent proteinuria >0.5 g/ 24 h that furtherly decline the renal function with the mean fall rate being around 1 ml/min/mo.
In other words, by treating hypertension and hyperglycemia in patients with diabetes, the progression of diabetics kidney disease may be slowed or preventable.
Some researchers suggested that
* By maintaining a healthy blood glucose levels and keeping them within the target range.
* By a change of healthful diet.
* By getting moderate and regular exercise
* By maintaining a healthy weight
* Particularly, by following a treatment plan, including the use of insulin or other medications.
Most common symptoms of diabetic nephropathy are worsening blood pressure control, protein in the urine, swelling of feet, ankles, hands or eyes, frequent urination, confusion or difficulty concentrating.
If you are diabetes associated with the aforementioned symptoms, please check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential and natural source for the treatment of diabetic complications, researchers examined the effects of bioactive compound curcumin anti-diabetic nephropathy (DN), the most common cause of end-stage renal disease in most parts of the world.
40 patients in the Diabetes Clinic of the Outpatient Department of Shiraz University of Medical Sciences on with overt type 2 diabetic nephropathy were randomized into a trial group (n = 20) and a control group (n = 20).
The treatment group received one capsule with each meal containing 500 mg turmeric, of which 22.1 mg was the active ingredient curcumin (three capsules daily) compared to the control group received three capsules identical in color and size containing starch for the period of 2 months.
Compared to the control group. patients treated with turmeric showed significantly reduced serum levels of transforming growth factor-β (TGF-β) and IL-8 associated with the production of pro-inflammatory cytokine and urinary protein excretion, the indications of kidney dysfunction.
The same results were also found in the comparison of the pre- and post-turmeric supplementation values.
Furthermore, there is no side effect reported in patients of the treatment group.
In other words, turmeric containing curcumin used in the experiment protects the kidney cells against the onset of diabetic nephropathy without inducing any adverse effects.
Dr. Khajehdehi P, the lead scientist based on the finding wrote, "Short-term turmeric supplementation can attenuate proteinuria, TGF-β, and IL-8 in patients with overt type 2 diabetic nephropathy and can be administered as safe adjuvant therapy for these patients".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of diabetic nephropathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of curcumin in experimental diabetic nephropathy by Prabhakar SS. (PubMed)
(2) Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study by Khajehdehi P1, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh G. (PubMed)
(3) The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy by C E Mogensen, C K Christensen and E Vittinghus(The Diabetes Association)
Long-term unmanaged hyperglycemia can damage the part of the kidneys thus reducing the kidney function in filter waste from the blood filters, leading to 'leaky' syndrome that allows protein into your urine.
Diabetic nephropathy is the 3 stage of kidney change in patients with diabetes. In this stage, patients may experience symptoms of abnormally elevated urinary albumin excretion, compared to the 15 and 300 μg/min in the baseline situation.
The progression of diabetic nephropathy that leads to an increased rate in albumin excretion is higher in patients with increased blood pressure.
More importantly, if high blood pressure is left untreated, diabetic nephropathy can induce persistent proteinuria >0.5 g/ 24 h that furtherly decline the renal function with the mean fall rate being around 1 ml/min/mo.
In other words, by treating hypertension and hyperglycemia in patients with diabetes, the progression of diabetics kidney disease may be slowed or preventable.
Some researchers suggested that
* By maintaining a healthy blood glucose levels and keeping them within the target range.
* By a change of healthful diet.
* By getting moderate and regular exercise
* By maintaining a healthy weight
* Particularly, by following a treatment plan, including the use of insulin or other medications.
Most common symptoms of diabetic nephropathy are worsening blood pressure control, protein in the urine, swelling of feet, ankles, hands or eyes, frequent urination, confusion or difficulty concentrating.
If you are diabetes associated with the aforementioned symptoms, please check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential and natural source for the treatment of diabetic complications, researchers examined the effects of bioactive compound curcumin anti-diabetic nephropathy (DN), the most common cause of end-stage renal disease in most parts of the world.
40 patients in the Diabetes Clinic of the Outpatient Department of Shiraz University of Medical Sciences on with overt type 2 diabetic nephropathy were randomized into a trial group (n = 20) and a control group (n = 20).
The treatment group received one capsule with each meal containing 500 mg turmeric, of which 22.1 mg was the active ingredient curcumin (three capsules daily) compared to the control group received three capsules identical in color and size containing starch for the period of 2 months.
Compared to the control group. patients treated with turmeric showed significantly reduced serum levels of transforming growth factor-β (TGF-β) and IL-8 associated with the production of pro-inflammatory cytokine and urinary protein excretion, the indications of kidney dysfunction.
The same results were also found in the comparison of the pre- and post-turmeric supplementation values.
Furthermore, there is no side effect reported in patients of the treatment group.
In other words, turmeric containing curcumin used in the experiment protects the kidney cells against the onset of diabetic nephropathy without inducing any adverse effects.
Dr. Khajehdehi P, the lead scientist based on the finding wrote, "Short-term turmeric supplementation can attenuate proteinuria, TGF-β, and IL-8 in patients with overt type 2 diabetic nephropathy and can be administered as safe adjuvant therapy for these patients".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of diabetic nephropathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of curcumin in experimental diabetic nephropathy by Prabhakar SS. (PubMed)
(2) Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study by Khajehdehi P1, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh G. (PubMed)
(3) The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy by C E Mogensen, C K Christensen and E Vittinghus(The Diabetes Association)
Monday, June 24, 2019
Soy and Menopause Symptoms in Japanese
Soybean, the genus Glycine, belonging to the family Fabaceae, one of the legumes contains twice as much protein per acre than any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A5. Soy and menopause symptom in Japan
Menopause is defined as a condition in which women have not had a menstrual period in a minimum of 12 months period as a result of the inactive ovaries, assuming the women are not pregnant and experience the ease of visible symptoms of menopause such as hot flashes and night sweats but not the invisible effects of menopause. During postmenopause, any bleeding or spotting should be reported to your doctor immediately, because it may be caused by tumors rarely but it is possible. Symptoms may include Bleeding or spotting, Vagina itching and dryness, Hot flash, Bone pain, and fracture, Bladder infection, Skin wrinkle, Hypertension, Bone density loss, etc.
Epidemiological studies, linking soy effects on menopause symptoms have been inconclusive(1)(2)(3)(4). In Japanese women, phytochemicals in soy found effectively in reduced vasomotor symptoms of menopause. In the study of a supplement containing equol on the menopausal symptoms in Japanese, researchers at the Tokyo Medical and Dental University, showed that the equol-ingesting group, not only significantly reduces severity and frequency of hot flashes, neck or shoulder but also exhibited trends of improvement in sweating and irritability and a significant improvement in the somatic category symptoms(5). Administration of 10-mg natural S-(-)equol supplement consumed daily for 12 weeks also indicated a reduction of hot flushes and neck or shoulder muscle stiffness, in postmenopausal Japanese women(6). And fermented soy products have been also showed to alleviate the severity of hot flushes(14).
Some researchers suggested that the effectiveness of soy isoflavone in relieving symptoms of menopause may link to equol-producing status. In a 1-year double-blind, randomized trial in comparison of the effects of isoflavone (75 mg of isoflavone conjugates/day) in early postmenopausal equol-producer phenotype Japanese women, found that isoflavones exhibit the preventive effects on bone loss and fat accumulation in early postmenopausal women, depending on an individual's equol-producing capacity(7) and S-equol supplement improved mood-related symptoms in perimenopausal/postmenopausal even in equol nonproducers in Japan women, in total of 127 participants completed the trial(8).
Soy isoflavone extracts on testing on the lumbar spine or hip BMD in menopausal women of controlled trials published in English, Japanese, or Chinese, showed a result of varying effects on spine BMD(9). In comparing the symptom of hot flash and chilliness in menopause women, Dr. Melby MK. suggested that Japanese women experience important vasomotor symptom than hot flushes and sweats, it may be a result of dietary high in soy(10).
In Osteoporosis, menaquinone-7, the major chemical compound found in Japanese fermented soybeans, showed to prevent postmenopausal bone loss(11) and promote bone formation(13)(15) as well alleviating early postmenopausal women symptoms, such as in palpitation and backaches(15). Another study also suggested that intake of supplementation of isoflavones (ISO) regular associates to risk reduction of osteoporosis in middle-aged Japanese and menopausal Japanese women(12).
In fact, according to the study of cross-sectional relationships of dietary and other lifestyle variables to menopause by the Gifu University School of Medicine, such as smoking, calcium, and soy product intakes, intakes of fat, cholesterol, and coffee were significantly associated with the onset menopause in Japanese women(16).
Taken altogether, High soy food intakes are associated to reduce symptoms of menopause in Japanese women, especially in the major menopausal symptom of chilliness. Intake of a supplement containing equol is effective in symptom reduction even in nonequol producers in these population as well. According to the Royal Hospital for Women, the highest soy consumption in Japan lowered the rates of diseases, including breast, endometrial, colon and prostatic cancers atherosclerotic, etc. The induced extremely high urinary levels of phytoestrogen metabolites may be a result of isoflavones in exhibited bioactivity when intake of high concentrations. (17)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) The Science of Soy: What Do We Really Know? by Julia R. Barrett
(b) Guideline for healthy soy intake(the Unite Soybean board)
(1c) Japan, Wikipedia
(1a) Erdman JW Jr. AHA Science Advisory: soy protein and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation. 2000; 102: 2555–2559
(Soy protein and cardiovascular disease)
(1b) van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation. 2005; 111: 465–471(Cardiovascular diseases in women)
(1) S-equol and the fermented soy product SE5-OH containing S-equol similarly decrease ovariectomy-induced increase in rat tail skin temperature in an animal model of hot flushes by Yoneda T1, Ueno T, Uchiyama S.(PubMed)
(2) A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency by Jenks BH1, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson WH, Ueno T, Uchiyama S.(PubMed)
(3) Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials by Taku K1, Melby MK, Kronenberg F, Kurzer MS, Messina M.(PubMed)
(4) Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial by Newton KM1, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J.(PubMed)
(5) Equol improves menopausal symptoms in Japanese women by Aso T.(PubMed)
(6) A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women by Aso T1, Uchiyama S, Matsumura Y, Taguchi M, Nozaki M, Takamatsu K, Ishizuka B, Kubota T, Mizunuma H, Ohta H.(PubMed)
(7) Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial by Wu J1, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y.(PubMed)
(8) New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women by Ishiwata N1, Melby MK, Mizuno S, Watanabe S.(PubMed)
(9) Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials by Taku K1, Melby MK, Takebayashi J, Mizuno S, Ishimi Y, Omori T, Watanabe S.(PubMed)
(10) Chilliness: a vasomotor symptom in Japan by Melby MK.(PubMed)
(11) Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study by Ikeda Y1, Iki M, Morita A, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H.(PubMed)
(12) Soy isoflavone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women by Mori M1, Aizawa T, Tokoro M, Miki T, Yamori Y.(PubMed)
(13) Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women by Katsuyama H1, Ideguchi S, Fukunaga M, Fukunaga T, Saijoh K, Sunami S.(PubMed)
(14) Hot flushes and other menopausal symptoms in relation to soyproduct intake in Japanese women by Nagata C1, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.(PubMed)
(15) Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women by Somekawa Y1, Chiguchi M, Ishibashi T, Aso T.(PubMed)
(16) Association of diet and other lifestyle with onset of menopause in Japanese women by Nagata C1, Takatsuka N, Inaba S, Kawakami N, Shimizu H.(PubMed)
(17) Phytoestrogens and the menopause by Mackey R1, Eden J.(PubMed)
Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.
Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).
A5. Soy and menopause symptom in Japan
Menopause is defined as a condition in which women have not had a menstrual period in a minimum of 12 months period as a result of the inactive ovaries, assuming the women are not pregnant and experience the ease of visible symptoms of menopause such as hot flashes and night sweats but not the invisible effects of menopause. During postmenopause, any bleeding or spotting should be reported to your doctor immediately, because it may be caused by tumors rarely but it is possible. Symptoms may include Bleeding or spotting, Vagina itching and dryness, Hot flash, Bone pain, and fracture, Bladder infection, Skin wrinkle, Hypertension, Bone density loss, etc.
Epidemiological studies, linking soy effects on menopause symptoms have been inconclusive(1)(2)(3)(4). In Japanese women, phytochemicals in soy found effectively in reduced vasomotor symptoms of menopause. In the study of a supplement containing equol on the menopausal symptoms in Japanese, researchers at the Tokyo Medical and Dental University, showed that the equol-ingesting group, not only significantly reduces severity and frequency of hot flashes, neck or shoulder but also exhibited trends of improvement in sweating and irritability and a significant improvement in the somatic category symptoms(5). Administration of 10-mg natural S-(-)equol supplement consumed daily for 12 weeks also indicated a reduction of hot flushes and neck or shoulder muscle stiffness, in postmenopausal Japanese women(6). And fermented soy products have been also showed to alleviate the severity of hot flushes(14).
Some researchers suggested that the effectiveness of soy isoflavone in relieving symptoms of menopause may link to equol-producing status. In a 1-year double-blind, randomized trial in comparison of the effects of isoflavone (75 mg of isoflavone conjugates/day) in early postmenopausal equol-producer phenotype Japanese women, found that isoflavones exhibit the preventive effects on bone loss and fat accumulation in early postmenopausal women, depending on an individual's equol-producing capacity(7) and S-equol supplement improved mood-related symptoms in perimenopausal/postmenopausal even in equol nonproducers in Japan women, in total of 127 participants completed the trial(8).
Soy isoflavone extracts on testing on the lumbar spine or hip BMD in menopausal women of controlled trials published in English, Japanese, or Chinese, showed a result of varying effects on spine BMD(9). In comparing the symptom of hot flash and chilliness in menopause women, Dr. Melby MK. suggested that Japanese women experience important vasomotor symptom than hot flushes and sweats, it may be a result of dietary high in soy(10).
In Osteoporosis, menaquinone-7, the major chemical compound found in Japanese fermented soybeans, showed to prevent postmenopausal bone loss(11) and promote bone formation(13)(15) as well alleviating early postmenopausal women symptoms, such as in palpitation and backaches(15). Another study also suggested that intake of supplementation of isoflavones (ISO) regular associates to risk reduction of osteoporosis in middle-aged Japanese and menopausal Japanese women(12).
In fact, according to the study of cross-sectional relationships of dietary and other lifestyle variables to menopause by the Gifu University School of Medicine, such as smoking, calcium, and soy product intakes, intakes of fat, cholesterol, and coffee were significantly associated with the onset menopause in Japanese women(16).
Taken altogether, High soy food intakes are associated to reduce symptoms of menopause in Japanese women, especially in the major menopausal symptom of chilliness. Intake of a supplement containing equol is effective in symptom reduction even in nonequol producers in these population as well. According to the Royal Hospital for Women, the highest soy consumption in Japan lowered the rates of diseases, including breast, endometrial, colon and prostatic cancers atherosclerotic, etc. The induced extremely high urinary levels of phytoestrogen metabolites may be a result of isoflavones in exhibited bioactivity when intake of high concentrations. (17)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) The Science of Soy: What Do We Really Know? by Julia R. Barrett
(b) Guideline for healthy soy intake(the Unite Soybean board)
(1c) Japan, Wikipedia
(1a) Erdman JW Jr. AHA Science Advisory: soy protein and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation. 2000; 102: 2555–2559
(Soy protein and cardiovascular disease)
(1b) van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation. 2005; 111: 465–471(Cardiovascular diseases in women)
(1) S-equol and the fermented soy product SE5-OH containing S-equol similarly decrease ovariectomy-induced increase in rat tail skin temperature in an animal model of hot flushes by Yoneda T1, Ueno T, Uchiyama S.(PubMed)
(2) A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency by Jenks BH1, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson WH, Ueno T, Uchiyama S.(PubMed)
(3) Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials by Taku K1, Melby MK, Kronenberg F, Kurzer MS, Messina M.(PubMed)
(4) Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial by Newton KM1, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J.(PubMed)
(5) Equol improves menopausal symptoms in Japanese women by Aso T.(PubMed)
(6) A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women by Aso T1, Uchiyama S, Matsumura Y, Taguchi M, Nozaki M, Takamatsu K, Ishizuka B, Kubota T, Mizunuma H, Ohta H.(PubMed)
(7) Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial by Wu J1, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y.(PubMed)
(8) New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women by Ishiwata N1, Melby MK, Mizuno S, Watanabe S.(PubMed)
(9) Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials by Taku K1, Melby MK, Takebayashi J, Mizuno S, Ishimi Y, Omori T, Watanabe S.(PubMed)
(10) Chilliness: a vasomotor symptom in Japan by Melby MK.(PubMed)
(11) Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study by Ikeda Y1, Iki M, Morita A, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H.(PubMed)
(12) Soy isoflavone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women by Mori M1, Aizawa T, Tokoro M, Miki T, Yamori Y.(PubMed)
(13) Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women by Katsuyama H1, Ideguchi S, Fukunaga M, Fukunaga T, Saijoh K, Sunami S.(PubMed)
(14) Hot flushes and other menopausal symptoms in relation to soyproduct intake in Japanese women by Nagata C1, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.(PubMed)
(15) Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women by Somekawa Y1, Chiguchi M, Ishibashi T, Aso T.(PubMed)
(16) Association of diet and other lifestyle with onset of menopause in Japanese women by Nagata C1, Takatsuka N, Inaba S, Kawakami N, Shimizu H.(PubMed)
(17) Phytoestrogens and the menopause by Mackey R1, Eden J.(PubMed)
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