Green tea, the Best in Prevention and Treatment of Chronic Inflammatory Diseases

Good news for people with chronic inflammatory diseases, green tea polyphenols (GrTPs) is found to reduced risk and progression of the diseases through the exhibition of potent antioxidants in regulating vital signaling pathways involved the production of inflammatory cytokines. a renowned institute study suggested

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger in each drink will attenuate the expression.

Chronic inflammation diseases are medical conditions caused by over reaction of the immune system in protection against microbial invasion and damage to organs due to injuring, affecting the tissue healing process, which can lead to life-long debilitation and loss of tissue function and organ failure.

According to the University of Kentucky Medical Center, green tea phytochemical polyphenols protected our body against inflammation through actions in intercepted the surge of inflammatory markers like cytokines and production of cyclooxygenase-2 in innate anti-inflammatory cytokines.

In chronic Inflammatory Bowel Disease patients, catechin isolated from green tea enhanced the antioxidant production such as glutathione peroxidases (GPO) and glutathione (GSH), in significantly inhibited excessive oxidative stress through direct or indirect in reducing the oxidative damages to the colon.

Dr. Fan FY, the lead author said, " catechins can exert their significant anti-inflammatory properties by regulating the activation or deactivation of inflammation-related oxidative stress-related cell signaling pathways( involved proinflammation specifically)".

Particularly, the study also specified, the impression of antioxidant catechin in stabilized the structure of the gastrointestinal micro-ecological environment via promoting the proliferation of beneficial intestinal bacteria and regulating the balance of intestinal flora for induction of relief in patients with IBD.

Furthermore, in a psoriasis mouse model, BALB/c mice topically treated with IMQ for 6 consecutive days, displayed a significant alleviated psoriasiform dermatitis, improved the skin pathological structure by reducing the expression of epidermal PCNA(Base cells) and promoted the expression of caspase-14 involved in inflammation.

In fact, according to the study, the efficacy of Epigallocatechin-3-gallate (EGCG), for treatment of
psoriasis-like inflammation is the result of the phytochemical functions in anti-inflammatory, immune regulatory and antioxidant activation.

Taking together, green tea may be used as a protectively functional food in the prevention and treatment of chronic inflammatory diseases, but regularly large amount injection should be avoided to prevent toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chronic Inflammatory Diseases and Green Tea Polyphenols by Oz HS1.(PubMed)
(2) Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease by Fan FY1, Sang LX2, Jiang M3.(PubMed)

Turmeric Protects the Kidney Against Renal Dysfunction

Renal protection is strategies that protect the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.

Kidneys, a pair of the bean-shaped organ in the human body only filters out blood but also balances the body fluids by eliminating them and remove them through urinary secretion.

Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness

In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.

The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.

Kidney damage can be classified into 4 different stages
* Stage 1 with normal or high GFR (GFR > 90 mL/min). In this stage of kidney patients are assymptomatic.

* Stage 2 Mild CKD (GFR = 60-89 mL/min), Patients in this stage also experience no symptoms.

*Stage 3A Moderate CKD (GFR = 45-59 mL/min) and 3B moderate CKD (GFR = 30-44 mL/min.
Most patients are assymptomatic. However, some patients may experience symptoms of mild swelling in the hands and feet, back pain and urinating more or less than normal.

* Stage 4 CKD (GFR = 15-30 mL/min). Most patients in this stage experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function

* Stage 5 EndStage CKD (GFR <15 mL/min). Patients at this advanced stage are very close to renal failure or renal failure. Symptoms are getting worse.

Where eGFR is short for estimated glomerular filtration rate.


Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a potential compound with the kidney protective effect against the side effects of Cisplatin, researchers investigated the protective effect and mechanism of tetrahydrocurcumin on cisplatin-induced kidney damage.

The study included selected rats treated by Tetrahydrocurcumin orally every day at a dose of 80 mg/kg body weight for ten days, and a single dose of cisplatin was administered intraperitoneally (7.5 mg/kg body weight) in 0.9 % saline on day four.

According to the tested assays, Cisplatin-induced renal cell damage was significantly reduced by tetrahydrocurcumin treatment.

Tetrahydrocurcumin also suppressed the cisplatin-treated rat in inducing overexpression of the creatinine clearance levels, an indication of kidney dysfunction.

Proinflammatory protein associated with increased oxidative stress in the kidney caused by cancer medicine was also inhibited by tetrahydrocurcumin administration during the experiment.

After taking into account co and confounders, the researcher wrote, "collectively provide therapeutic evidence that tetrahydrocurcumin ameliorates renal damage by regulating inflammation and apoptosis".

In order to reveal more information about turmeric renal protective activity, researchers evaluated the intervening effects of Curcuma aromatica oil on renal interstitial fibrosis rats induced by unilateral ureteral obstruction.


The study included infected rats treated with Curcuma aromatica oil on 3, 7, 14, and 28 days.
According to the Nuclear magnetic resonance (NMR)-based metabonomics combined with clinical chemistry and histopathology examination, Curcuma aromatica oil demonstrated strong kidney protection by inhibiting some metabolic pathways associated with the onset of renal interstitial fibrosis, including lipids metabolism, glycolysis, and methylamine metabolism,

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the protection of kidneys, pending to the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effect of tetrahydrocurcumin against cisplatin-induced renal damage: in vitro and in vivo studies by Song KI1, Park JY2, Lee S3, Lee D2, Jang HJ4, Kim SN3, Ko H5, Kim HY6, Lee JW3, Hwang GS2, Kang KS2, Yamabe N. (PubMed)
(2) Serum metabonomic analysis of protective effects of Curcuma aromatica oil on renal fibrosis rats by Zhao L1, Zhang H1, Yang Y2, Zheng Y1, Dong M1, Wang Y1, Bai G3, Ye X3, Yan Z3, Gao H. (PubMed)

Green Tea, the Best Anti Asthma Functional Whole Food

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But adding a slice of ginger will solve the problem.

According to the joint study lead by the Ben Gurion University of the Negev, Kaempferol (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), a flavonoid found in green tea exhibited anti-oxidant/anti-inflammatory effects against various diseases, including asthma.



The study also demonstrated the function of Kaempferol in reduced oxidative stress through scavenging free radicals and superoxide radicals effects as well as preserving the activity of various anti-oxidant enzymes in attenuated production of proinflammatory cytokines.

In fact, evidence from in vitro and in vivo assays postulated that aqueous fraction of green tea also exerted anti-asthmatic signaling activity in the ovalbumin-induced asthmatic model.

Furthermore, in the study of mice induced asthma by an ovalbumin, aqueous extract of green tea displayed a potent anti-asthmatic activity by increasing the expression level of tumor necrosis factor-beta, (a protein involved production of one of the inflammatory cytokines in the acute phase) and interferon-gamma in displacement of immune function against microbial infection and decreased expression of anti-asthmatic cytokines in the lung.


More importantly, green tea alleviated asthmatic symptoms by increasing the expression of Th1 cell-in regulated the production of interferon-gamma and interleukin (IL)-2, proinflammatory cytokines and tumor necrosis factor.

Promisingly, another green tea constituent, namely Chafuroside A (CFA), water-soluble flavone C-glycoside, in experimental asthma/chronic obstructive pulmonary disease (COPD)-rat model, treatment with Chafuroside A at 0.5mg/kg, 1.0mg/kg could attenuate inflammatory symptoms and ameliorate antigen-induced airway inflammation, respectively.


Dr, Onoue S, the lead author in the above study said, " A self-assembled micellar (SAM) formulation might be an efficacious approach for enhancing the therapeutic potential of CFA for treatment of inflammatory diseases".

Unfortunately, there are few reports suggested that green tea-induced asthma in tea-sensitive patients, as epigallocatechin gallate induced histamine release through IgE-mediated response.


Taking together, there is no doubt that green tea may be considered as a functional food for prevention and treatment of asthma, but people with tea sensitive syndrome should avoid drinking green tea unless with approval of related field specialist.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Kaempferol, a potential cytostatic and cure for inflammatory disorders by Rajendran P1, Rengarajan T1, Nandakumar N2, Palaniswami R3, Nishigaki Y1, Nishigaki I4.(PubMed)
(2) An aqueous extract of green tea Camellia sinensis increases expression of Th1 cell-specific anti-asthmatic markers by Heo JC1, Rho JR, Kim TH, Kim SY, Lee SH.(PubMed)
(3) Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats by Onoue S1, Matsui T, Aoki Y, Ishida H, Nukaya H, Kou K, Yamada S.(PubMed)

Soy and Risk of Breast cancer in Japanese Population

Soy foods, including tofu, have been in traditional Chinese diet over thousands of year, according to Chinese literature. The reduced risk of chronic disease in the Asian population, including metabolic syndrome such as cardiovascular diseases, obesity and diabetes, and lesser menopause symptoms in advanced age, may be aided by eating a lot of soy food accompanied with a large portion of vegetables and fruits. Indeed, according to the study, only 10% of women in the East are experiencing symptoms of menopause in advanced age compared to over 70% of their Western counterparts.
According to Dr. Mark Messina, Ph.D., Soy foods contributed from 6.5%8 to 12.8%7 of total protein intake in an older adult in Japan. (b)

The approval of cardiovascular benefit of soy by FDA in 1999 accompanied with the discovery of health benefits in clinical studies over the past decade, prompted the promotion and advertisement of soy's health benefits in every aspect in Western society. Evidence could be seen by walking through the supermarkets and drug stores. Soy supplements and products such as tofu, soy milk, soy-based infant formula, and meatless “texturized vegetable protein” burgers were widely available. According to the United Soybean Board’s 2004–2005, 25% of Americans consumed soy foods or beverages at least once per week, and 74% viewed soy products as healthy.

Today, the promotion of soy no longer exists, it may be results of the discovery of adverse effects in single ingredient and animal studies, as intake of soy is associated to induce the risk of certain mammary cancers and infertility. The publication of the result has drawn many criticisms. According to Thomas Badger, director, and senior investigator at the Arkansas Children’s Nutrition Center in Little Rock, these effects are seen only under certain experimental conditions that are not likely to occur in humans—and therein lies the crux of the debate(a). Equol (4',7-isoflavandiol), an isoflavandiol metabolized from daidzein may be the causes, as 90% of Eastern population are equol producers but only 30% in the West.

The explanation of the positive effect of soy isoflavones in reduced risk of mammary cancers by the University of Goettingen may be interesting, as researchers said" Most importantly, there is a dispute as to whether isoflavones derived from soy or red clover have negative, positive or any effect at all on the mammary gland or endometrium. It is beyond any doubt that soy products may have cancer-preventing properties in a variety of organs including the mammary gland. However, these properties may only be exerted if the developing organ was under the influence of isoflavones during childhood and puberty".

Soybean is a genus Glycine, belonging to the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Essential amino acid
6. Vitamin A
7. Vitamin B6
8. Vitamin B12
9. Vitamin C
10. Vitamin K
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc
18. Etc.

Phytochemicals
1. Isoflavones
2. Genistein
3. Saponins
4. Beta-sitosterol
5. Daidzein

I. Soy in Eastern population
A. The Japanese population
Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years healthy living with disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(d)(e).
A.2. Soy and Risk of Breast cancer in Japanese Population
Breast cancer (malignant breast neoplasm) is cancer started in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. There are also rare cases that breast cancer started in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the life time of a woman is 1/8.
The searching of the keyword in PubMed with keywords, soy and breast cancer in Japanese women, found 15 related studies.
Epidemiologic evidence suggesting a high intake of soy in the Japanese population is associated to reduce risk of breast cancer(1) and regular consumption of probiotic beverage and isoflavones since adolescence was inversely associated with the incidence of breast cancer in Japanese women(2)(2a).

The study in the testing of oral administration of IF-rich tablet (20 and 40 mg/day) on climacteric women, showed the product not only reduced risk of breast cancer but also improved of bone density, hypertension, and climacteric symptoms, cardiovascular diseases, gynecological problems and possible immune potentiation(3)

Japanese women have a lower incidence of and mortality from breast cancer, compared to Caucasians, it may be a result of large amount intake soy protein and isoflavones, as high dietary intake of phytoestrogens, mainly in the form of soy products, can produce circulating levels of phytoestrogens that are known experimentally to have oestrogenic effects(4).

According to the Loma Linda University, Asian population consumes as much as 25 g of soy protein or 100 mg of isoflavones per day(5).
Epidemiological Western studies have linked levels of Genistein and daidzein in stimulating breast tumor growth and antagonize the effects of tamoxifen have been inclusive. Some researchers suggested that women with current or past breast cancer should be aware of the risks of potential tumor growth when taking soy products(6).

In the Japanese population, the serum of isoflavones and insulin levels were not associated with breast cancer risk, in a case-control study of 63 histologically confirmed breast cancer patients and 76 controls, of serum isoflavone, insulin and adiponectin levels with breast cancer risk(7).

The review of Soy for breast cancer survivors also rejected the above claim of adult consumption of soy affecting the risk of developing breast cancer or that soy consumption affects the survival of breast cancer patients(8). Indeed, in Japanese study in testing the serum concentrations of genistein and daidzein, showed urinary excretion in 10 women and 9 men who consumed a typical low-fat diet with much rice and soy products, fish, and vegetables, in a rural village south of Kyoto, Japan, indicated a co-related to isoflavonoids intake and serum concentrations of genistein and daidzein and suggested that these may be a result of low mortality in breast and prostate cancer of Japanese women and men, respectively(9). In fact, tofu is found to be associated with the serum concentrations of genistein and daidzein but the fermented product, such as miso showed a slight association with serum concentrations of these phytoestrogens with serum concentrations of equol showed associated with dietary intake of tofu and miso soup(10).

Soymilk, a flavored drink on breakfast in the Asian diet, when combined with combination with probiotic Lactobacillus casei Shirota (LcS) also showed to prevent the development of mammary tumors through suppression of tumor growth and might be a beneficial dietary style for breast cancer prevention(11). Intake of soy combined with seaweed in equol producers, showed seaweed favorably alters estrogen and phytoestrogen metabolism and these changes likely include modulation of colonic bacteria, in healthy postmenopausal women(12). In premenopausal Japanese women study with randomly assigned to receive either a soymilk-supplemented diet (n = 31) or a normal (control) diet (n = 29), involved three consecutive menstrual cycles showed the estrone and estradiol levels were decreased by 23% and 27%, respectively, in the soymilk-supplemented group but insisted that larger studies will be required to confirm the ability of soy products to reduce serum estrogen levels(12a). Another study in 50 healthy premenopausal Japanese women, also showed a similar result as blood samples drawn from each subject on Days 11 and 22 of her menstrual cycle, suggested that the consumption of soy products lowers the risk of developing breast cancer risk in modifying estrogen metabolism(12b).

In postmenopausal Japanese women, according to the study from the Takayama, with participants members aged 35 years or older in 1992 with follow-up was conducted from the time of the baseline study (September 1, 1992) to the end of March 2008, concluded that soy and isoflavone intakes may have a protective effect on postmenopausal breast cancer. Risks of breast cancer were decreased among women with a moderate intake of soy and isoflavone(13).

In a total of 678 breast cancer cases and 3,390 age- and menopausal status-matched noncancer controls, soy showed a protective effect against breast cancer risk differs by receptor status, including with ER-positive (ER+) and HER2-negative (HER2-)(14). Genistein a major component of soybean isoflavone, has been found to induce breast cancer in some Western study, also exerted its anti-breast cancer preventive effect in a breast cancer cell overexpressing HER-2, as genistein enhances necrotic-like cell death of the breast cancer cells through the inactivation of the HER-2 receptor and Akt which plays a key role in multiple cellular processes in combined with chemotherapeutic agent (15).

Unfortunately, report on a Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 30,454 women aged 40-79 years, completed a questionnaire on diet and other lifestyle features, suggested that consumption of soy food has no protective effects against breast cancer, but insisted that further large-scale investigations eliciting genetic factors may clarify different roles of various soybean-ingredient foods on the risk of breast cancer(16).

According to DR. Nagata C. the protective risk against breast cancer only found in Asian but not Western populations with the intake of soy, may be due to consuming levels of soy typical in Asian diets. Researchers should also take account of the amount of soy isoflavones consumed, the form and food source of isoflavones, the timing of isoflavone exposure, estrogen receptor status of tumors, and equol-producer status and hormonal profile of individuals. These factors might explain the heterogeneity of results from studies(17).


Conclusion
Dr, Rice S. Dr. Whitehead SA., in the differentiation of phytoestrogens and breast cancer--promoters or protectors? said "a paradox concerning the epidemiology of breast cancer and the dietary intake of phytoestrogens that bind weakly to estrogen receptors and initiate estrogen-dependent transcription. In Eastern countries, such as Japan, the incidence of breast cancer is approximately one-third that of Western countries whilst their high dietary intake of phytoestrogens, mainly in the form of soy products, can produce circulating levels of phytoestrogens that are known experimentally to have oestrogenic effects. The actions of phytoestrogens on estrogen receptors and key enzymes that convert androgens to estrogens in relation to the growth of breast cancer cells. In addition, it compares the experimental and epidemiological evidence pertinent to the potential beneficial or harmful effects of phytoestrogens in relation to the incidence/progression of breast cancer and their efficacy as natural alternatives to conventional HRT"(18).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(a) The Science of Soy: What Do We Really Know? by Julia R. Barrett
(b) Guideline for healthy soy intake(the Unite Soybean board)
(c) Japan, Wikipedia
(d) Erdman JW Jr. AHA Science Advisory: soy protein and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation. 2000; 102: 2555–2559
(Soy protein and cardiovascular disease)
(e) van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation. 2005; 111: 465–471(Cardiovascular diseases in women)
(1) Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population(PubMed)
(2) Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study by Toi M1, Hirota S, Tomotaki A, Sato N, Hozumi Y, Anan K, Nagashima T, Tokuda Y, Masuda N, Ohsumi S, Ohno S, Takahashi M, Hayashi H, Yamamoto S, Ohashi Y.(PubMed)
(2a) Yamamoto S1, Sobue T, Kobayashi M, Sasaki S, Tsugane S; JapanPublic Health Center-Based Prospective Study on Cancer Cardiovascular Diseases Group.(PubMed)
(3) Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation by Watanabe S1, Uesugi S, Kikuchi Y.(PubMed)
(4) Phytoestrogens and breast cancer--promoters or protectors? by Rice S1, Whitehead SA.(PubMed)
(5) Estimated Asian adult soy protein and isoflavone intakes, by Messina M1, Nagata C, Wu AH.(PubMed).
(6) Effects of soy phytoestrogens genistein and daidzein on breast cancergrowth by de Lemos ML.(PubMed)
(7) Minatoya M1, Kutomi G, Asakura S, Otokozawa S, Sugiyama Y, Ohnishi H, Akasaka H, Miura T, Mori M, Hirata K.(PubMed)
(8) Soy for breast cancer survivors: a critical review of the literature by Messina MJ1, Loprinzi CL.(PubMed)
(9) Association of serum phytoestrogen concentration and dietary habits in a sample set of the JACC Study by Ozasa K1, Nakao M, Watanabe Y, Hayashi K, Miki T, Mikami K, Mori M, Sakauchi F, Washio M, Ito Y, Suzuki K, Kubo T, Wakai K, Tamakoshi A; JACC Study Group.(PubMed)
(10) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet by Adlercreutz H1, Honjo H, Higashi A, Fotsis T, Hämäläinen E, Hasegawa T, Okada H.(PubMed)
(11) Lactobacillus casei Shirota enhances the preventive efficacy of soymilk in chemically induced breast cancer by Kaga C1, Takagi A, Kano M, Kado S, Kato I, Sakai M, Miyazaki K, Nanno M, Ishikawa F, Ohashi Y, Toi M.(PubMed)
(12) Dietary seaweed modifies estrogen and phytoestrogen metabolism in healthy postmenopausal women by Teas J1, Hurley TG, Hebert JR, Franke AA, Sepkovic DW, Kurzer MS.(PubMed)
(12a) Effect of soymilk consumption on serum estrogen concentrations in premenopausal Japanese women by Nagata C1, Takatsuka N, Inaba S, Kawakami N, Shimizu H.(PubMed)
(12b) Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women by Nagata C1, Kabuto M, Kurisu Y, Shimizu H.(PubMed)
(13) Soy isoflavone intake and breast cancer risk in Japan: from the Takayama study by Wada K1, Nakamura K, Tamai Y, Tsuji M, Kawachi T, Hori A, Takeyama N, Tanabashi S, Matsushita S, Tokimitsu N, Nagata C.(PubMed)
(14) Effect of soybean on breast cancer according to receptor status: a case-control study in Japan by Suzuki T1, Matsuo K, Tsunoda N, Hirose K, Hiraki A, Kawase T, Yamashita T, Iwata H, Tanaka H, Tajima K.(PubMed)
(15) Genistein, a soy isoflavone, enhances necrotic-like cell death in a breast cancer cell treated with a chemotherapeutic agent by Satoh H1, Nishikawa K, Suzuki K, Asano R, Virgona N, Ichikawa T, Hagiwara K, Yano T.(PubMed)
(16) Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study by Nishio K1, Niwa Y, Toyoshima H, Tamakoshi K, Kondo T, Yatsuya H, Yamamoto A, Suzuki S, Tokudome S, Lin Y, Wakai K, Hamajima N, Tamakoshi A(PubMed)
(17) Factors to consider in the association between soy isoflavone intake and breast cancer risk.
PubMed)
(18) Phytoestrogens and breast cancer--promoters or protectors? by Rice S1, Whitehead SA.(PubMed)

Green Tea Reduce Symptoms Expression and Complications of Rheumatoid Arthritis

Green tea exhibited anti-inflammatory effect in reduced symptoms and progression of
Rheumatoid Arthritis, a renowned institute study suggested

Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body after the ages of 40 and causing the diminished quality of life of many elders.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including dizziness, low energy, weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the joint study led by Washington State University College of Pharmacy, green tea (EGCG, EGC, and EC) showed to ameliorate the expression of pro-inflammatory mediators including (IL-6 and IL-8) and Cox-2 in primary human rheumatoid arthritis synovial fibroblasts (RASFs), through the effects of its phytochemical compounds of EGCG and EGC antioxidant activities.

Dr. Fechtner S, the lead researcher said," EGCG is the most effective catechin at inhibiting downstream inflammatory signaling, its effectiveness could be hindered by the presence of (epicatechin) EC".


In the investigation of the anti-inflammatory activity of green versus black tea aqueous extract in a rat model with orally/daily distilled water as placebo, indomethacin (1.0 mg/kg body weight; a non-steroidal/anti-inflammatory drug), or tea aqueous extracts (for 28 or 14 consecutive days administrated from day 0 or 14 of arthritis induction, respectively), group treated with high dose of GTE (from day 0) significantly alleviated (P < 0.05-0.001) the progression and all complications induced by rheumatoid arthritis in compared placebo.


More importantly, Researchers also found that the expression of anti-arthritic activity of the high dose of GTE (from day 0) mediated by significantly decreasing the systemic production of pro-inflammatory cytokines and the expression of chemokine receptor-5, a protein in activated immune activities in the in synovial tissues, was comparable (P > 0.05) with that of indomethacin (12.9-53.8 vs. 9.5-48.4%, respectively).
Furthermore, the anti-arthritic potency of tea aqueous extracts was dosed dependent in the order of high dose of GTE > low dose of GTE ≥ high dose of BTE > low dose of BTE.

Other study suggested that green tea extract in reduced symptoms and risk of complication probably are the result in regulating chemokine(a family of cytokines secreted by cells) production in an immune reaction and chemokine receptor expression in interaction with proinflammatory cytokines of human RA synovial fibroblasts in rat adjuvant-induced arthritis (AIA).

Taking together, green tea nay be served as a functional food to reduce symptoms and risk of complication for patients with rheumatoid arthritis.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts by Fechtner S1, Singh A1, Chourasia M2, Ahmed S3.(PubMed)
(2) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)
(3) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)

Bromelain Protects the Cardiac Muscle in Blood Circulation

Cardiac muscle or heart muscle or myocardium is a type of muscle that helps the heart to pump blood to nourish the entire body by performing the coordinated contractions.


Damage of heart muscle can lead to cardiomyopathy, or heart muscle disease, leading to abnormally heart enlarged, thickened, and/or stiffened.

In other words, cardiomyopathy reduced the heart muscle ability to pump blood, causing heart failure and the backup of blood into the lungs or the rest of the body.


Most common types of cardiomyopathy are
* Dilated cardiomyopathy is a condition caused by the enlarged and weakened the left ventricle.

* Hypertrophic cardiomyopathy is a result of the thickening of the heart muscle, at the septum between the ventricles, below the aortic valve.

* Ischemic cardiomyopathy is the condition caused by narrow arteries that affect the supply blood to the heart muscle.

* Restrictive cardiomyopathy is a condition that the walls of the lower chambers of the ventricles are too rigid to expand


Most common symptoms of cardiomyopathy are associated with reduce blood flow due to reduced function of heart muscle including general weakness and fatigue, shortness of breath, particularly during exertion or exercise, lightheadedness, and dizziness, chest pain, heart palpitations, fainting attacks, high blood pressure, edema, or swelling, of your feet, ankles, and legs.


If you have experienced some of the aforementioned symptoms, please check with your doctor to rule out the possibility of cardiomyopathy.


Out of many factors associated with the risk of cardiomyopathy, some researchers suggested that long-term alcoholism may be the major culprit.


Dr. B. Maisch wrote, " Moderate drinking can reduce the incidence and mortality of coronary artery disease, heart failure, diabetes, ischemic and hemorrhagic stroke".


However, "More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites".

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential ingredient for the improvement of cardiovascular circulation, researchers examined the effect of bromelain on ischemia/reperfusion (IR) injury is characterized by the production of oxygen-free radicals leading to disturbances in vasomotility (microvascular constriction) and microvascular permeability (interstitial edema formation).

The study included a rabbit hindlimb model of I/R (2.5/2 h) were given Phlogenzym, containing rutin, trypsin, and bromelain enterally (60 mg/kg body weight) 30 min prior to ischemia (Ph group).

Before treatment with Phlogenzym, two hours after reperfusion, potassium levels were significantly elevated in IR compared to the Ph group.

Application of Phlogenzym inhibited the enhanced lipid peroxidation, apparent by increased plasma malondialdehyde levels in the Ph group, particularly, in the reduction of blood flow.

Furthermore, Phlogenzym treatment also prevented microvascular constriction and mollified interstitial edema

In other words, Phlogenzym protects the cardiac muscle in blood circulation against damage caused by ischemia/reperfusion (I/R) injury.

Based on the findings, researchers wrote, "Phlogenzym had a protective effect on skeletal muscle during I/R injury expressed by prevention of no-reflow and preservation of muscle tissue".

Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the protection of heart muscle, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
Bromelain Osteoarthritis
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) The result of dosage and individual predisposition. Alcoholic cardiomyopathy by B. Maisch. (PMC)

Green Tea, The Best Functional Food In Reduced Risk and Treatment of Breast Cancer

Green tea may be the next generation of inexpensive herbal medicine for reduced risk and treatment of breast cancer, a renowned institute study suggested

Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that breast cancer starts in other areas of the breast.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

According to the joint study lead by the Xinyang Normal UniversityHenan, Epigallocatechin-3-gallate (EGCG), a bioactive compound in green tea inhibited the risk of breast cancer through many mechanisms involving primarily in cell death and survival.

The study also insisted on the efficacy of Epigallocatechin-3-gallate (EGCG) in reduced risk of breast cancer probably due to the main function in induced cancer cell cycle arrest in interference of cell division.

In MDA-MB-231 breast cancer cell line, Epigallocatechin gallate isolated from green tea-induced apoptosis and inhibited tumorigenesis through the expression of multiple signaling pathways in breast cancer cells.


Also, EGCG decreased MDA-MB-231 cell viability and significantly downregulated the expression of β-catenin in regulated the coordination of cell-cell adhesion and gene transcription, according to Western blot analysis as patients with breast cancer is found to associate to high levels of β-catenin in breast cancer tissue than in normal tissue.

Dr. Hong OY, the lead author said, "EGCG inhibits the growth of MDA-MB-231 cells through the inactivation of the β-catenin signaling pathway. Based on these promising results, EGCG may be a potential treatment for triple negative breast cancer patients.".


In polychlorinated biphenyls (PCBs) accumulated in human breast cancer tissue induced the growth of estrogen-sensitive tumors, EGCG inhibited the early onset of breast cancer through modifying estrogenic activity against cell proliferation in a dose-dependent manner.


Furthermore, at a dose of at 25 μM, EGCG also exerted antiproliferative and pro-apoptotic action in the activation of the ERβ receptor.

With all the information collected above, green tea, containing rich sources of anti malignant and nonmalignant tumors phytochemicals, may be considered as a functional food in reduced risk and treatment of breast cancer.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bioinformatic Prediction of Possible Targets and Mechanisms of Action of the Green TeaCompound Epigallocatechin-3-Gallate Against Breast Cancer by Song X1,2, Zhang M3, Chen L1, Lin Q2.(PubMed)
(2) Epigallocatechin gallate inhibits the growth of MDA-MB-231 breast cancer cells via inactivation of the β-catenin signaling pathway by Hong OY1, Noh EM2, Jang HY1, Lee YR2, Lee BK3, Jung SH3, Kim JS1, Youn HJ3.(PubMed)
(3) Green Tea Catechin, EGCG, Suppresses PCB 102-Induced Proliferation in Estrogen-Sensitive Breast Cancer Cells by Baker KM1, Bauer AC2.(PubMed)