Green tea may have a substantial and profound effect in reduced risk of ischemic related diseases, some scientists postulated.
Ischemic related diseases are the class of disease caused overexpression of free radicals in the induction of lipid peroxidation including atherosclerosis, ischemia-reperfusion, heart failure, Alzheimer's disease, rheumatic arthritis, cancer, and other immunological disorders.
The investigation of green tea effect and risk ischemic related diseases in a total of 9 studies selected from medical literature published through October 2014, satisfied the criteria and guideline, including 259,267 individuals showed that people who do not consume green tea express a higher risks of CVD of 1.19, intracerebral hemorrhage of 1.24, and cerebral infarction of 1.15 in compared to those drinking <1 cup green tea per day.
For those who drank 1-3 cups of green tea per day, risk of myocardial infarction and stroke are reduced to risk ratio of 0.81 and 0.64, respectively, in compared to those who drank <1 cup/day.
Not surprisingly, those who drank ≥4 cups/day had a reduced risk ratio of 0.68 of myocardial infarction in compared to those who drank <1 cup/day.
And finally, people consumed ≥10 cups/day of green tea were also found to lower LDL with risk ratio of 0.90 in compared to the <3 cups/day group.
The findings of meta-study indicated a strong implication of green tea intake linearly associated to reduce risk ischemic related diseases.
People who are at higher risk of ischemic related diseases may want to add a cup or 2 of green tea as a beverage in their diet for preventive measure.
Further illustration of the effect of green tea in reduced risk of ischemic related diseases researchers at the Second Affiliated Hospital of Zhengzhou University conducted a study to investigate the EGCG activity in the acute phase of ischemic stroke, indicated that pretreatment of EGCG displays a significant effect in reduced risk ischemic stroke via nuclear factor erythroid 2-related factor 2 (Nfr2) signaling pathway, the expression of antioxidant proteins that protect against oxidative damage triggered by ROS in induction of injury and inflammation.
In a rat model of transient middle cerebral artery occlusion, EGCG treatment demonstrated a significant effect on the expression of the neurologic outcome, with less infarct volume, more number of Ki67/CD31-positive vessels, higher expression of the number of microvessels in tissue, thus increasing blood flow in the brain, compared to mice group treated only with MCAO.
Furthermore, the application of green tea also exerted a significant antioxidant effect in inhibited the overproduction of ROS in the induction of chain reactive through activated Nrf2 expression, thus decreasing oxidative stress in compared to MCAO+vehicle-treated mice.
Interestingly, EGCG also up regulated the VEGF-VEGFR2 signaling pathway which plays important roles in the development and function of the circulatory and nervous systems, involved providing nutrients and oxygen and induced protective effects on brain neurons.
After taking into account of other con founders, Dr. the lead researcher concluded, "EGCG treatment in the early stage of ischemic stroke can promote angiogenesis in MCAO mice, possibly via upregulation of Nrf2 signaling pathway".
Taken together, green tea with abundant bioactive polyphenols such as Epigallocatechin-3-gallate (EGCG) may be considered as a functional food in reduced risk and treatment of ischemic related diseases, particularly in the high-risk population. Intake of green tea extract should be taken exceptional care as overdose can induce acute liver toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke by Bai Q1, Lyu Z2, Yang X1, Pan Z3, Lou J4, Dong T5.(PubMed)
(2) Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis by Pang J1, Zhang Z2, Zheng TZ3, Bassig BA4, Mao C5, Liu X5, Zhu Y4, Shi K6, Ge J7, Yang YJ8, Dejia-Huang5, Bai M9, Peng Y9.(PubMed)
Thursday, August 22, 2019
Wednesday, August 21, 2019
Green tea and Its Polyphenols in Reduced Risk, Progression, Complications and Treatment of Liver Cirrhosis
Green tea may have a therapeutic and positive effect in reduced risk and treatment of liver cirrhosis, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Liver cirrhosis is a condition of abnormal function of the liver due to damage liver tissue replaced by scar tissue.
According to statistic, the risk of liver cirrhosis is 1.6% in the adult population.
Green tea polyphenols in reduced risk and treatment of patients with liver cirrhosis were found to associate to numbers of implication, involving various mechanisms.
In male SD rats model induced liver cirrhosis through carbon tetrachloride(CCL4), randomly assigned to 3 groups, including normal group, green tea extract (GTE) group and cirrhosis group, with GTE group and the cirrhosis group were injected subcutaneously 2 times/wk over 9 weeks with 40% Carbon tetrachloride (CCl4), researcher found that green tea treatment groups displayed a significant reduction of concentration of hydroxyproline, an amino acid produced during the hydrolysis of collagen initiate scar accumulation in the liver damage tissue caused by CCl4) in compared to cirrhosis group.
Further analysis, also indicated that green tea exhibited antioxidant activities in decreased expression of malondialdehyde (MDA), a highly toxic reactive species in precipitated liver damage induced by application of carbon tetrachloride(CCL4).
Additionally, the green tea extract ameliorated the liver damage cell in the formation of cirrhosis through attenuating the expression of transforming growth factor-beta 1 or TGF-β1 in initiated cell growth, cell proliferation.
In differentiation of 11 patients with hepatitis C and detectable viremia of 4 Child-Pugh (CP) class A cirrhosis, 4 Child-Pugh class B cirrhosis, and 3 noncirrhotic, researchers at the Thomas Jefferson University indicated that injection of a single oral dose of green tea extract 400 mg containing 94% pure EGCG demonstrated a strong effect in reduced cirrhosis overexpression in induction of liver tumor growth by inhibiting the virus hepatitis in facilitate the production of ROS species through chronic liver inflammation, according to the blood sample withdrawn from the patients without inducing liver toxicity.
Dr. Halegoua-De Marzio D, after taking into account of other confounders said, "A single 400-mg oral dose of EGCG was safe and well-tolerated by all of the patients in the study" and disposition of EGCG was not significantly altered in these patients with cirrhosis".
Interestingly, in the concern of abnormal angiogenesis in patients with liver cirrhosis in induction of severe complications such as variceal haemorrhage and encephalopathy, Dr. Hsu SJ and colleges conducted a study to investigate the effect of green tea extract in Sprague-Dawley rats liver induced in by common BDL (bile duct ligation) in compared to control given distill water for 28 days and found that group treated with green tea extract expressed a strong implication in ameliorated the severity of portosystemic shunting, a rare malformation of the vessels supplying blood to the liver caused by excessive shunting of blood from the liver portal vein to the lower and middle body into the right atrium of the heart due to liver cirrhosis in induction portal hypertension and one of complication of variceal haemorrhage in patient with chronic liver cirrhosis and mesenteric angiogenesis in development of new blood vessels to supply oxygen and nutrients to initiate liver cancer.
Moreover, the effect of green tea GTP extract in reduced progression of liver cirrhosis was attributed to the suppression of hypoxia-inducible factor 1-alpha (HIF-1α) in expression of liver disease of diverse etiologies, including chronic liver diseases caused by viral infection, excessive alcohol consumption and activation of protein kinase B (Akt) in regulated infectious liver cell survival, cell-cycle progression,... and levels of VEGF in reflection of increased portal hypertension or decreased hepatic regenerative activity or the combination of both.
Dr.Hsu SJ, the lead author said after the conclusion, "GTP appears to be an appropriate agent in controlling portal hypertension-related complications via anti-angiogenesis.
Taken together, Green tea extract containing major polyphenols such as EGCG may be considered as a functional food in reduced risk, progression, complications and treatment of liver cirrhosis. Intake of green tea supplement should be taken with special care to prevent acute toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis by Hsu SJ, Wang SS, Hsin IF, Lee FY, Huang HC, Huo TI, Lee WS, Lin HC, Lee SD.(PubMed)
(2) [Green tea extracts protected against carbon tetrachloride-induced chronic liver damage and cirrhosis].[Article in Chinese] by Xiao J1, Lu R, Shen X, Wu M.(PubMed)
(3) Limited sampling estimates of epigallocatechin gallate exposures in cirrhotic and noncirrhotic patients with hepatitis C after single oral doses of green tea extract by Halegoua-De Marzio D1, Kraft WK, Daskalakis C, Ying X, Hawke RL, Navarro VJ.(PubMed)
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Liver cirrhosis is a condition of abnormal function of the liver due to damage liver tissue replaced by scar tissue.
According to statistic, the risk of liver cirrhosis is 1.6% in the adult population.
Green tea polyphenols in reduced risk and treatment of patients with liver cirrhosis were found to associate to numbers of implication, involving various mechanisms.
In male SD rats model induced liver cirrhosis through carbon tetrachloride(CCL4), randomly assigned to 3 groups, including normal group, green tea extract (GTE) group and cirrhosis group, with GTE group and the cirrhosis group were injected subcutaneously 2 times/wk over 9 weeks with 40% Carbon tetrachloride (CCl4), researcher found that green tea treatment groups displayed a significant reduction of concentration of hydroxyproline, an amino acid produced during the hydrolysis of collagen initiate scar accumulation in the liver damage tissue caused by CCl4) in compared to cirrhosis group.
Further analysis, also indicated that green tea exhibited antioxidant activities in decreased expression of malondialdehyde (MDA), a highly toxic reactive species in precipitated liver damage induced by application of carbon tetrachloride(CCL4).
Additionally, the green tea extract ameliorated the liver damage cell in the formation of cirrhosis through attenuating the expression of transforming growth factor-beta 1 or TGF-β1 in initiated cell growth, cell proliferation.
In differentiation of 11 patients with hepatitis C and detectable viremia of 4 Child-Pugh (CP) class A cirrhosis, 4 Child-Pugh class B cirrhosis, and 3 noncirrhotic, researchers at the Thomas Jefferson University indicated that injection of a single oral dose of green tea extract 400 mg containing 94% pure EGCG demonstrated a strong effect in reduced cirrhosis overexpression in induction of liver tumor growth by inhibiting the virus hepatitis in facilitate the production of ROS species through chronic liver inflammation, according to the blood sample withdrawn from the patients without inducing liver toxicity.
Dr. Halegoua-De Marzio D, after taking into account of other confounders said, "A single 400-mg oral dose of EGCG was safe and well-tolerated by all of the patients in the study" and disposition of EGCG was not significantly altered in these patients with cirrhosis".
Interestingly, in the concern of abnormal angiogenesis in patients with liver cirrhosis in induction of severe complications such as variceal haemorrhage and encephalopathy, Dr. Hsu SJ and colleges conducted a study to investigate the effect of green tea extract in Sprague-Dawley rats liver induced in by common BDL (bile duct ligation) in compared to control given distill water for 28 days and found that group treated with green tea extract expressed a strong implication in ameliorated the severity of portosystemic shunting, a rare malformation of the vessels supplying blood to the liver caused by excessive shunting of blood from the liver portal vein to the lower and middle body into the right atrium of the heart due to liver cirrhosis in induction portal hypertension and one of complication of variceal haemorrhage in patient with chronic liver cirrhosis and mesenteric angiogenesis in development of new blood vessels to supply oxygen and nutrients to initiate liver cancer.
Moreover, the effect of green tea GTP extract in reduced progression of liver cirrhosis was attributed to the suppression of hypoxia-inducible factor 1-alpha (HIF-1α) in expression of liver disease of diverse etiologies, including chronic liver diseases caused by viral infection, excessive alcohol consumption and activation of protein kinase B (Akt) in regulated infectious liver cell survival, cell-cycle progression,... and levels of VEGF in reflection of increased portal hypertension or decreased hepatic regenerative activity or the combination of both.
Dr.Hsu SJ, the lead author said after the conclusion, "GTP appears to be an appropriate agent in controlling portal hypertension-related complications via anti-angiogenesis.
Taken together, Green tea extract containing major polyphenols such as EGCG may be considered as a functional food in reduced risk, progression, complications and treatment of liver cirrhosis. Intake of green tea supplement should be taken with special care to prevent acute toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis by Hsu SJ, Wang SS, Hsin IF, Lee FY, Huang HC, Huo TI, Lee WS, Lin HC, Lee SD.(PubMed)
(2) [Green tea extracts protected against carbon tetrachloride-induced chronic liver damage and cirrhosis].[Article in Chinese] by Xiao J1, Lu R, Shen X, Wu M.(PubMed)
(3) Limited sampling estimates of epigallocatechin gallate exposures in cirrhotic and noncirrhotic patients with hepatitis C after single oral doses of green tea extract by Halegoua-De Marzio D1, Kraft WK, Daskalakis C, Ying X, Hawke RL, Navarro VJ.(PubMed)
Betacyanins Inhibits Inflammatory Bowel Disease (IBD) in Vitro
Inflammation is a natural reaction of the immune system against the invasion of the foreign stimuli and pathogens with an aim to protect our body from infection.
In the acute phase of tissue damage or injury, after receiving the information from the neurotransmitters, the white blood cells that response for the first line of defense activate the production of blood platelets and the inflammatory cytokines to the site of infection to destroy the invasive agents.
However, in most cases, overproduction of inflammatory cytokines can damage the nearby cells that lead to improper healing with the formation of scars.
Inflammatory bowel disease (IBD), a class of chronic conditions associated with the inflammation of the digestive tract, can be classified into
* Ulcerative colitis is found in the innermost lining of the colon and rectum.
* Crohn's disease is a type of IBD that causes inflammation of the lining of the digestive tract, other than the colon and rectum.
Epidemiological studies suggested that patients with IBD are associated with the symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss. Long-term persistent symptoms such as weight loss may be life-threatening.
If you have experienced some of the aforementioned symptoms, please make sure to check with your doctor to rule out the possibility.
The causes of IBD are unknown. The alternation of the ratio of gut microbiota may be the major culprit in facilitating the onset of IBD.
Dr. Becker C, the lead scientist wrote, "The intestinal microbiota has important metabolic and host-protective functions. Conversely, to these beneficial functions, the intestinal microbiota is thought to play a central role in the etiopathogenesis of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis), chronic inflammation of the gut mucosa".
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural pigment for the prevention and treatment of colonic inflammation, researchers examined the effects of beetroot (Beta vulgaris var. Rubra) products and their major component betanin found in betacyanins in patients with inflammatory bowel disease (IBD).
According to the tested assays,
* Betanin at the concentration of 100 μM for 24 h increased DNA damage in IBD patients' neutrophils. In other words, betanin exhibited cytotoxic activity against the neutrophils isolated from the blood of patients with inflammatory bowel disease--ulcerative colitis (UC) and Crohn's disease (CD), compared to those obtained in colon carcinoma-derived Caco-2 cells.
* Furthermore, betanin treatment in Caco-2 cells with H2O2 also caused a 4-fold increase of DNA strand breaks compared to untreated cells. More precisely, betanin elevated the expression of free radical H2O2 to cause cancer cell death.
* Moreover, pre-treatment with betanin was found to reduce DNA damage in healthy normal cells.
* Additonally, betanin also promoted the activity of procaspase and caspase pro-apoptotic activity to induce cancer cells apoptosis.
Based on the findings, Dr. the lead scientist said, "These results suggest that betanin may support mechanisms that lead to the release of ROS and apoptotic cell death. In this way, betanin may exert anti-inflammatory and potentially cancer-preventive activity".
Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) The Intestinal Microbiota in Inflammatory Bowel Disease by Becker C1, Neurath MF1, Wirtz S. (PubMed)
In the acute phase of tissue damage or injury, after receiving the information from the neurotransmitters, the white blood cells that response for the first line of defense activate the production of blood platelets and the inflammatory cytokines to the site of infection to destroy the invasive agents.
However, in most cases, overproduction of inflammatory cytokines can damage the nearby cells that lead to improper healing with the formation of scars.
Inflammatory bowel disease (IBD), a class of chronic conditions associated with the inflammation of the digestive tract, can be classified into
* Ulcerative colitis is found in the innermost lining of the colon and rectum.
* Crohn's disease is a type of IBD that causes inflammation of the lining of the digestive tract, other than the colon and rectum.
Epidemiological studies suggested that patients with IBD are associated with the symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss. Long-term persistent symptoms such as weight loss may be life-threatening.
If you have experienced some of the aforementioned symptoms, please make sure to check with your doctor to rule out the possibility.
The causes of IBD are unknown. The alternation of the ratio of gut microbiota may be the major culprit in facilitating the onset of IBD.
Dr. Becker C, the lead scientist wrote, "The intestinal microbiota has important metabolic and host-protective functions. Conversely, to these beneficial functions, the intestinal microbiota is thought to play a central role in the etiopathogenesis of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis), chronic inflammation of the gut mucosa".
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural pigment for the prevention and treatment of colonic inflammation, researchers examined the effects of beetroot (Beta vulgaris var. Rubra) products and their major component betanin found in betacyanins in patients with inflammatory bowel disease (IBD).
According to the tested assays,
* Betanin at the concentration of 100 μM for 24 h increased DNA damage in IBD patients' neutrophils. In other words, betanin exhibited cytotoxic activity against the neutrophils isolated from the blood of patients with inflammatory bowel disease--ulcerative colitis (UC) and Crohn's disease (CD), compared to those obtained in colon carcinoma-derived Caco-2 cells.
* Furthermore, betanin treatment in Caco-2 cells with H2O2 also caused a 4-fold increase of DNA strand breaks compared to untreated cells. More precisely, betanin elevated the expression of free radical H2O2 to cause cancer cell death.
* Moreover, pre-treatment with betanin was found to reduce DNA damage in healthy normal cells.
* Additonally, betanin also promoted the activity of procaspase and caspase pro-apoptotic activity to induce cancer cells apoptosis.
Based on the findings, Dr. the lead scientist said, "These results suggest that betanin may support mechanisms that lead to the release of ROS and apoptotic cell death. In this way, betanin may exert anti-inflammatory and potentially cancer-preventive activity".
Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) The Intestinal Microbiota in Inflammatory Bowel Disease by Becker C1, Neurath MF1, Wirtz S. (PubMed)
Tuesday, August 20, 2019
Green Tea and Bioactive Polyphenols Epigallocatechin gallate (EGCG) in Protection Against Memory Deficits
Green tea may have a therapeutic and positive effect in protecting against memory deficits, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.ore
Memory deficit is a medical condition characterized lost of the ability in-store and recall past information, such as knowledge, sensation, thoughts,......
Lost of memory function is not only associated with normal aging progression in the adult population but considered as a feature of neurodegenerative diseases, including psychiatric and neurological disorders.
According to the Harvard neuro discovery center, today, approximately 5 million Americans suffer from Alzheimer's disease; 1 million from Parkinson's; 400,000 from multiple sclerosis (MS); 30,000 from amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), and 30,000 from Huntington's disease.
The evaluate green tea extract (GTex) and its major functional polyphenol (−)-epigallocatechin gallate (EGCG) effect on memory of cerebral ischemic rats showed that green tea EGCG and pentoxifylline (PTX), a methylxanthine derivative with anti-inflammatory function, application after 1 hour demonstrates a strong efficacy in improved ishemic-induced memory impairment, according to Morris water maze test.
Long term treatment of green tea EGCG also displayed a significant increase level of antioxidant such as malondialdehyde (MDA) levels, glutathione (GSH), and superoxide dismutase (SOD) activity in the cerebral cortex and hippocampus, through prevented cerebral infraction breakdown of MDA and GSH in the hippocampus, in protected against damage to cellular components caused by reactive oxygen species (ROS) including free radicals, peroxides, lipid peroxides....
Further analysis, green tea EGCG inhibited BV-2 microglial cells in the induction of brain inflammatory effect in precipitated neurodegeneration and neurotoxicology to facilitate memory impairment, through ameliorated the expression of lipopolysaccharide- (LPS-) in exhibited free radical nitric oxide production which is associated to in initiated neurotoxicity.
Additionally, the application also ameliorated the cyclooxygenase-2 (COX-2) expression associated with pro-inflammatory activities in mediated neurodegenerative processes of several acute and chronic diseases and expression of the inducible nitric oxide synthase (iNOS), one of the direct consequences of an inflammatory process in the BV-2 cells.
In short, the experiment of cerebral ischemia animal model indicated that green extract and its active polyphenol EGCG improved learning and memory deficits through exhibited antioxidant activity in the reduction of oxidative stress and neuroinflammation.
Moreover, green tea Epigallocatechin gallate (EGCG) with beneficial effects on the impairment in learning and memory also demonstrated in increased autophagic activation in getting rid of damaged and dysfunctional cell accumulation to protect healthy neuron from stressful conditions, such as overexpression of ROS presentation, according to the experiment of chronic unpredictable mild stress (CUMS)-induced cognitive impairment in rats and observed through the elevated LC3-II, a reliable method for monitoring autophagy and autophagy-related processes, including autophagic cell death. and p62 protein level, a useful marker for the induction of autophagy,
At the same time, the green tea EGCG also displayed a strong inhibition of increased neuronal loss and activated mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6k) signaling caused by implication of chronic unpredictable mild stress (CUMS) in the CA1 regions in the hippocampal circuit in initiation of the pathophysiology of memory deficits, thus reducing amyloid beta1-42 (Aβ1-42) deposit, and restored autophagic degradation activity.
Mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6k) signaling pathway is an essential cellular signaling pathway involved a number of important physiological functions, including cell growth, proliferation, metabolism, protein synthesis, and autophagy.
Taken together, green tea and its bioactive polyphenols Epigallocatechin gallate (EGCG) may be considered an adjunct therapy in reduced risk and enhanced standard medicine for the treatment of memory deficits.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation by Kuo-Jen Wu,1 Ming-Tsuen Hsieh,1 Chi-Rei Wu,1 W. Gibson Wood,2 and Yuh-Fung Chen(Hindawi)
(2) Epigallocatechin-3-Gallate Attenuates Impairment of Learning and Memory in Chronic Unpredictable Mild Stress-Treated Rats by Restoring Hippocampal Autophagic Flux by Hong-Feng Gu1,2., Ya-Xiong Nie3., Qiao-Zhen Tong2., Ya-Ling Tang1 , Yang Zeng3 , Kai-Quan Jing3 , XiLong Zheng2,4, Duan-Fang Liao4(PLOS 1)
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.ore
Memory deficit is a medical condition characterized lost of the ability in-store and recall past information, such as knowledge, sensation, thoughts,......
Lost of memory function is not only associated with normal aging progression in the adult population but considered as a feature of neurodegenerative diseases, including psychiatric and neurological disorders.
According to the Harvard neuro discovery center, today, approximately 5 million Americans suffer from Alzheimer's disease; 1 million from Parkinson's; 400,000 from multiple sclerosis (MS); 30,000 from amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), and 30,000 from Huntington's disease.
The evaluate green tea extract (GTex) and its major functional polyphenol (−)-epigallocatechin gallate (EGCG) effect on memory of cerebral ischemic rats showed that green tea EGCG and pentoxifylline (PTX), a methylxanthine derivative with anti-inflammatory function, application after 1 hour demonstrates a strong efficacy in improved ishemic-induced memory impairment, according to Morris water maze test.
Long term treatment of green tea EGCG also displayed a significant increase level of antioxidant such as malondialdehyde (MDA) levels, glutathione (GSH), and superoxide dismutase (SOD) activity in the cerebral cortex and hippocampus, through prevented cerebral infraction breakdown of MDA and GSH in the hippocampus, in protected against damage to cellular components caused by reactive oxygen species (ROS) including free radicals, peroxides, lipid peroxides....
Further analysis, green tea EGCG inhibited BV-2 microglial cells in the induction of brain inflammatory effect in precipitated neurodegeneration and neurotoxicology to facilitate memory impairment, through ameliorated the expression of lipopolysaccharide- (LPS-) in exhibited free radical nitric oxide production which is associated to in initiated neurotoxicity.
Additionally, the application also ameliorated the cyclooxygenase-2 (COX-2) expression associated with pro-inflammatory activities in mediated neurodegenerative processes of several acute and chronic diseases and expression of the inducible nitric oxide synthase (iNOS), one of the direct consequences of an inflammatory process in the BV-2 cells.
In short, the experiment of cerebral ischemia animal model indicated that green extract and its active polyphenol EGCG improved learning and memory deficits through exhibited antioxidant activity in the reduction of oxidative stress and neuroinflammation.
Moreover, green tea Epigallocatechin gallate (EGCG) with beneficial effects on the impairment in learning and memory also demonstrated in increased autophagic activation in getting rid of damaged and dysfunctional cell accumulation to protect healthy neuron from stressful conditions, such as overexpression of ROS presentation, according to the experiment of chronic unpredictable mild stress (CUMS)-induced cognitive impairment in rats and observed through the elevated LC3-II, a reliable method for monitoring autophagy and autophagy-related processes, including autophagic cell death. and p62 protein level, a useful marker for the induction of autophagy,
At the same time, the green tea EGCG also displayed a strong inhibition of increased neuronal loss and activated mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6k) signaling caused by implication of chronic unpredictable mild stress (CUMS) in the CA1 regions in the hippocampal circuit in initiation of the pathophysiology of memory deficits, thus reducing amyloid beta1-42 (Aβ1-42) deposit, and restored autophagic degradation activity.
Mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6k) signaling pathway is an essential cellular signaling pathway involved a number of important physiological functions, including cell growth, proliferation, metabolism, protein synthesis, and autophagy.
Taken together, green tea and its bioactive polyphenols Epigallocatechin gallate (EGCG) may be considered an adjunct therapy in reduced risk and enhanced standard medicine for the treatment of memory deficits.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation by Kuo-Jen Wu,1 Ming-Tsuen Hsieh,1 Chi-Rei Wu,1 W. Gibson Wood,2 and Yuh-Fung Chen(Hindawi)
(2) Epigallocatechin-3-Gallate Attenuates Impairment of Learning and Memory in Chronic Unpredictable Mild Stress-Treated Rats by Restoring Hippocampal Autophagic Flux by Hong-Feng Gu1,2., Ya-Xiong Nie3., Qiao-Zhen Tong2., Ya-Ling Tang1 , Yang Zeng3 , Kai-Quan Jing3 , XiLong Zheng2,4, Duan-Fang Liao4(PLOS 1)
Whole Food Tomatoes prostate (PC3) Protects The Cells of Prostate Gland Against Prostate Cancer, Studies Show
Prostate cancer is a medical condition caused by irregular cell growth in the tissues of the prostate.
The prostate is a male reproductive gland that plays a critical role in the contribution of nutrients and fluid to sperm.
Most cases of prostate cancer start in the cells on the surface in the inner lining of the prostate tissue before penetrating into deeper prostate gland layers to induce metastasis via blood and lymph.
At the early stage, due to the very small size of the tumor, prostate cancer is asymptomatic.
Most common symptoms of the prostate at the later stage are frequent urination, weak or interrupted urine flow due to the tumor that affects the tube surrounded by the prostate.
In some case, patients may experience symptoms of blood in the urine and pain due to the oversize tumor that has pressed on the nearby blood vessels and nerve cells.
The new onset of erectile dysfunction is also common in patients with prostate cancer.
The causes of prostate cancer are not identified. However, the increase in aging is one of the most common risk factors as most cases of the condition are diagnosed in older adults. Approximately, 60% of all cases are diagnosed in men over 65.c
According to the statistics, in 2017, 21,300 men were diagnosed with prostate cancer and the disease cause the death of 4,100 men in the same year.
The 5-year survival rate for most men with local or regional prostate cancer is nearly 100% compared to only 30% in patients diagnosed with prostate cancer that has spread to other parts of the body,
Some researchers in the concern that the risk of prostate cancer in the younger population suggested that the promotion of a high-fat diet over the past few decades may be correlated to the rise of the disease.
Dr. Colleen Pelser, the lead scientist wrote, "Total fat and mono- and polyunsaturated fat INTAKES were not associated with the incidence of prostate cancer. Saturated fat intake was related to increased risk of advanced prostate cancer (HRQuintile 5 vs. Quintile 1 (Q1 vs. Q5)1.21; 95% CI 1.00–1.46; p-for-trend=0.03) and fatal prostate cancer".
And. "Our study suggests that the associations of fat and fatty acids differ by prostate cancer severity. Saturated fat, ALA and EPA intakes were related to the risk of advanced or fatal prostate cancer, but not to non-advanced prostate cancer".
The results strongly suggested that if you are a high-fat diet follower, your risk of prostate cancer is increased substantially compared to a traditional diet.
Tomato is red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a natural compound for the treatment of prostate cancer, researchers investigated the effects of lycopene-rich tomato on prostate-specific antigen (PSA) in prostate cancer patients.
The study included 79 patients with prostate cancer randomized to a nutritional intervention with either 1) tomato products containing 30 mg lycopene per day; 2) tomato products plus selenium, omega-3 fatty acids, soy isoflavones, grape/pomegranate juice, and green/black tea (tomato-plus); or 3) control diet for 3 weeks.
According to the results of the tested, the tomato group showed a significant PSA decrease compared to controls.
Compared to other groups, median PSA-values decreased by 1% in patients with the highest increases in plasma lycopene, selenium, and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium, and C20:5 n-3 fatty acid.
In other words, PSA decreased the most in patients with the highest increase in lycopene alone.
Based on the findings, researchers said, "Three-week nutritional interventions with tomato-products alone or in combination with selenium and n-3 fatty acids lower PSA in patients with non-metastatic prostate cancer".
Moreover, in the investigation of the association between tomato consumption and prostate cancer risk, researchers at Zhejiang University performed a meta-analysis to comprehensively evaluate this relationship.
Geographically, tomato intake showed significant protective effects in patients with Asian origin and Oceania populations compared to other regions.
According to the total of 24 published studies with 15,099 cases, tomato intake was associated with a reduced risk of prostate cancer with the RRs of 0.76 found in the case-control and cohort studies.
Taken altogether, tomatoes may be considered supplements for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA by Paur I1, Lilleby W2, Bøhn SK3, Hulander E4, Klein W5, Vlatkovic L6, Axcrona K7, Bolstad N8, Bjøro T9, Laake P10, Taskén KA11, Svindland A12, Eri LM13, Brennhovd B14, Carlsen MH15, Fosså SD16, Smeland SS17, Karlsen AS18, Blomhoff R. (PubMed)
(2) Tomato consumption and prostate cancer risk: a systematic review and meta-analysis by Xu X1, Li J1, Wang X1, Wang S1, Meng S1, Zhu Y1, Liang Z1, Zheng X1, Xie L. (PubMed)
(3). Dietary Fat, Fatty Acids and Risk of Prostate Cancer in the NIH-AARP Diet and Health Study
Colleen Pelser,1 Alison M. Mondul,2 Albert R. Hollenbeck,3 and Yikyung Park. (PMC)
The prostate is a male reproductive gland that plays a critical role in the contribution of nutrients and fluid to sperm.
Most cases of prostate cancer start in the cells on the surface in the inner lining of the prostate tissue before penetrating into deeper prostate gland layers to induce metastasis via blood and lymph.
At the early stage, due to the very small size of the tumor, prostate cancer is asymptomatic.
Most common symptoms of the prostate at the later stage are frequent urination, weak or interrupted urine flow due to the tumor that affects the tube surrounded by the prostate.
In some case, patients may experience symptoms of blood in the urine and pain due to the oversize tumor that has pressed on the nearby blood vessels and nerve cells.
The new onset of erectile dysfunction is also common in patients with prostate cancer.
The causes of prostate cancer are not identified. However, the increase in aging is one of the most common risk factors as most cases of the condition are diagnosed in older adults. Approximately, 60% of all cases are diagnosed in men over 65.c
According to the statistics, in 2017, 21,300 men were diagnosed with prostate cancer and the disease cause the death of 4,100 men in the same year.
The 5-year survival rate for most men with local or regional prostate cancer is nearly 100% compared to only 30% in patients diagnosed with prostate cancer that has spread to other parts of the body,
Some researchers in the concern that the risk of prostate cancer in the younger population suggested that the promotion of a high-fat diet over the past few decades may be correlated to the rise of the disease.
Dr. Colleen Pelser, the lead scientist wrote, "Total fat and mono- and polyunsaturated fat INTAKES were not associated with the incidence of prostate cancer. Saturated fat intake was related to increased risk of advanced prostate cancer (HRQuintile 5 vs. Quintile 1 (Q1 vs. Q5)1.21; 95% CI 1.00–1.46; p-for-trend=0.03) and fatal prostate cancer".
And. "Our study suggests that the associations of fat and fatty acids differ by prostate cancer severity. Saturated fat, ALA and EPA intakes were related to the risk of advanced or fatal prostate cancer, but not to non-advanced prostate cancer".
The results strongly suggested that if you are a high-fat diet follower, your risk of prostate cancer is increased substantially compared to a traditional diet.
Tomato is red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a natural compound for the treatment of prostate cancer, researchers investigated the effects of lycopene-rich tomato on prostate-specific antigen (PSA) in prostate cancer patients.
The study included 79 patients with prostate cancer randomized to a nutritional intervention with either 1) tomato products containing 30 mg lycopene per day; 2) tomato products plus selenium, omega-3 fatty acids, soy isoflavones, grape/pomegranate juice, and green/black tea (tomato-plus); or 3) control diet for 3 weeks.
According to the results of the tested, the tomato group showed a significant PSA decrease compared to controls.
Compared to other groups, median PSA-values decreased by 1% in patients with the highest increases in plasma lycopene, selenium, and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium, and C20:5 n-3 fatty acid.
In other words, PSA decreased the most in patients with the highest increase in lycopene alone.
Based on the findings, researchers said, "Three-week nutritional interventions with tomato-products alone or in combination with selenium and n-3 fatty acids lower PSA in patients with non-metastatic prostate cancer".
Moreover, in the investigation of the association between tomato consumption and prostate cancer risk, researchers at Zhejiang University performed a meta-analysis to comprehensively evaluate this relationship.
Geographically, tomato intake showed significant protective effects in patients with Asian origin and Oceania populations compared to other regions.
According to the total of 24 published studies with 15,099 cases, tomato intake was associated with a reduced risk of prostate cancer with the RRs of 0.76 found in the case-control and cohort studies.
Taken altogether, tomatoes may be considered supplements for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato-based randomized controlled trial in prostate cancer patients: Effect on PSA by Paur I1, Lilleby W2, Bøhn SK3, Hulander E4, Klein W5, Vlatkovic L6, Axcrona K7, Bolstad N8, Bjøro T9, Laake P10, Taskén KA11, Svindland A12, Eri LM13, Brennhovd B14, Carlsen MH15, Fosså SD16, Smeland SS17, Karlsen AS18, Blomhoff R. (PubMed)
(2) Tomato consumption and prostate cancer risk: a systematic review and meta-analysis by Xu X1, Li J1, Wang X1, Wang S1, Meng S1, Zhu Y1, Liang Z1, Zheng X1, Xie L. (PubMed)
(3). Dietary Fat, Fatty Acids and Risk of Prostate Cancer in the NIH-AARP Diet and Health Study
Colleen Pelser,1 Alison M. Mondul,2 Albert R. Hollenbeck,3 and Yikyung Park. (PMC)
Monday, August 19, 2019
Green tea and Its Bioactive Polyphenols in Ameliorated Risk Human Immunodeficiency Virus -1 (HIV-1) Infection
Green and black tea may have a therapeutic and positive effect in reduced risk of HIV 1 infection, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated of acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...
According to statistic, approximately 36.7 million people worldwide living with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.
According to the investigation of Theaflavins, the major components of tea polyphenols extracted from brewed black tea and green tea inhibited HIV-1 entry by targeting gp41 which is a transmembrane protein with function in embedded with an outer coat of HIV to enter and infected host cells.
However, due to the unstable and purified of the individual theaflavins, natural preparation containing 90% of theaflavins (TFmix) in the most study was used to experiment of its effect against HIV-1 microbicide for preventing HIV sexual transmission.
In vitro using p24 production and luciferase assays, TFmix exhibited potent anti-HIV-1 activity on lab-adapted and primary HIV-1 strains with IC(50), the concentration of an application that gives half-maximal response in dose of less than 1.20 μM, through targeting the gp41 in inhibited virus-host membrane fusion during infection mediated by the formation of six-helix bundle (6HB).
In other words, theaflavins administration was found to initiate potent anti-HIV-1 activity by targeting the viral entry step through the disruption of gp41 6-HB core structure,
Furthermore, application of theaflavins (TFmix) also inhibited reverse transcriptase (RT) activity, an RNA-dependent DNA, which is the process in replication of RNA from a DNA template through polymerase (DNAP) enzyme in forming new copies of DNA, in the form of nucleic acid molecules, with the IC(50) about 8-fold higher of theaflavins (TFmix) concentration than that for inhibiting gp41 6-HB formation.
In peptide fragments, derived from prostatic acidic phosphatase secreted in large amounts into human semen to form amyloid fibrils plaques with function to induced viral infection (SEVI), through capturing the HIV virions and direct them to target cells into liver cell to initiated entry step, during sexual activity, injection of green tea epigallocatechin-3-gallate (EGCG) inhibited the expression of SEVI and revoked semen in mediated enhancement of HIV-1 infection through precipitated viral degradation without induced healthy cell toxicity.
Further analysis of green tea EGCG activity using HIV-1 infectivity on human CD4+ T cells, at a physiologic concentration of 6μM, EGCG significantly inhibited HIV-1 p24 antigen production in the expression of acute infection in both HIV-1 clinical isolates and laboratory-adapted subtypes B C, D, and G.
Particularly, EGCG-induced inhibition of HV-1 infectivity was not due to cytotoxicity, cell growth inhibition, nor apoptosis but blocking the HIV activity in the attachment of HIV-1-gp120, a glycoprotein exposed on the surface of the HIV envelope to the CD4 molecule in the entry point in initiated infectivity.Dr. Christina L., the lead author concluded, "(by) preventing the attachment of HIV-1-gp120 to the CD4 molecule, EGCG inhibits HIV-1 infectivity. As this inhibition can be achieved at physiologic concentrations, the natural anti-HIV agent, EGCG, is a candidate as an alternative therapy in HIV-1 therapy".
The information findings suggested that green tea with abundant bioactive polyphenols Theaflavins including epigallocatechin-3-gallate (EGCG) may be considered as a functional food to the ameliorated risk of HIV 1 infection by blocking the complex process in initiation.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection by Hauber I1, Hohenberg H, Holstermann B, Hunstein W, Hauber J.(PubMed)
(2) A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection by Yang J1, Li L, Tan S, Jin H, Qiu J, Mao Q, Li R, Xia C, Jiang ZH, Jiang S, Liu S.(PubMed)
(3) Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41 by Liu S1, Lu H, Zhao Q, He Y, Niu J, Debnath AK, Wu S, Jiang S.(PubMed)
(4) Preclinical Development of the Green Tea Catechin, Epigallocatechin Gallate, as an HIV-1 Therapy by Christina L. Nance, Ph.D.,a Edward B. Siwak, Ph.D.,b and William T. Shearer, MD, Ph.Da(PMC)
(5) The HIV-1 gp41 N-terminal heptad repeat plays an essential role in membrane fusion by Sackett K1, Shai Y.(PubMed)
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated of acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...
According to statistic, approximately 36.7 million people worldwide living with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.
According to the investigation of Theaflavins, the major components of tea polyphenols extracted from brewed black tea and green tea inhibited HIV-1 entry by targeting gp41 which is a transmembrane protein with function in embedded with an outer coat of HIV to enter and infected host cells.
However, due to the unstable and purified of the individual theaflavins, natural preparation containing 90% of theaflavins (TFmix) in the most study was used to experiment of its effect against HIV-1 microbicide for preventing HIV sexual transmission.
In vitro using p24 production and luciferase assays, TFmix exhibited potent anti-HIV-1 activity on lab-adapted and primary HIV-1 strains with IC(50), the concentration of an application that gives half-maximal response in dose of less than 1.20 μM, through targeting the gp41 in inhibited virus-host membrane fusion during infection mediated by the formation of six-helix bundle (6HB).
In other words, theaflavins administration was found to initiate potent anti-HIV-1 activity by targeting the viral entry step through the disruption of gp41 6-HB core structure,
Furthermore, application of theaflavins (TFmix) also inhibited reverse transcriptase (RT) activity, an RNA-dependent DNA, which is the process in replication of RNA from a DNA template through polymerase (DNAP) enzyme in forming new copies of DNA, in the form of nucleic acid molecules, with the IC(50) about 8-fold higher of theaflavins (TFmix) concentration than that for inhibiting gp41 6-HB formation.
In peptide fragments, derived from prostatic acidic phosphatase secreted in large amounts into human semen to form amyloid fibrils plaques with function to induced viral infection (SEVI), through capturing the HIV virions and direct them to target cells into liver cell to initiated entry step, during sexual activity, injection of green tea epigallocatechin-3-gallate (EGCG) inhibited the expression of SEVI and revoked semen in mediated enhancement of HIV-1 infection through precipitated viral degradation without induced healthy cell toxicity.
Further analysis of green tea EGCG activity using HIV-1 infectivity on human CD4+ T cells, at a physiologic concentration of 6μM, EGCG significantly inhibited HIV-1 p24 antigen production in the expression of acute infection in both HIV-1 clinical isolates and laboratory-adapted subtypes B C, D, and G.
Particularly, EGCG-induced inhibition of HV-1 infectivity was not due to cytotoxicity, cell growth inhibition, nor apoptosis but blocking the HIV activity in the attachment of HIV-1-gp120, a glycoprotein exposed on the surface of the HIV envelope to the CD4 molecule in the entry point in initiated infectivity.Dr. Christina L., the lead author concluded, "(by) preventing the attachment of HIV-1-gp120 to the CD4 molecule, EGCG inhibits HIV-1 infectivity. As this inhibition can be achieved at physiologic concentrations, the natural anti-HIV agent, EGCG, is a candidate as an alternative therapy in HIV-1 therapy".
The information findings suggested that green tea with abundant bioactive polyphenols Theaflavins including epigallocatechin-3-gallate (EGCG) may be considered as a functional food to the ameliorated risk of HIV 1 infection by blocking the complex process in initiation.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection by Hauber I1, Hohenberg H, Holstermann B, Hunstein W, Hauber J.(PubMed)
(2) A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection by Yang J1, Li L, Tan S, Jin H, Qiu J, Mao Q, Li R, Xia C, Jiang ZH, Jiang S, Liu S.(PubMed)
(3) Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41 by Liu S1, Lu H, Zhao Q, He Y, Niu J, Debnath AK, Wu S, Jiang S.(PubMed)
(4) Preclinical Development of the Green Tea Catechin, Epigallocatechin Gallate, as an HIV-1 Therapy by Christina L. Nance, Ph.D.,a Edward B. Siwak, Ph.D.,b and William T. Shearer, MD, Ph.Da(PMC)
(5) The HIV-1 gp41 N-terminal heptad repeat plays an essential role in membrane fusion by Sackett K1, Shai Y.(PubMed)
Healthy Food Navy Bean Promotes Colon Health through Modulating Microbiome Metabolism
The colon formed part of the digestive system plays a critical role to absorb water from the small bowel contents and break down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colon health is the process to enhance the function of the colon through many mechanisms, particularly, in the improvement of the ratio of gut microbiota.
Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.
Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.
In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.
Epidemiological studies suggested overweight and obese people show a dysbiosis characterized by a lower diversity. Imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.
Some researchers suggested that we can optimize our colon health by manipulating the gut microbiota through diet by increasing the intake fiber, prebiotic and probiotic foods.
Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".
And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.
On finding a natural compound for the improvement of colon health, researchers evaluated the effect of navy beans in the modulation of the host-microbiome metabolism.
The 4-week, randomized controlled trial with overweight and obese CRC survivors involved consumption of 1 meal and 1 snack daily, containing 35 g of cooked navy bean or macronutrient matched meals and snacks with 0 g of navy beans for the control group (n = 18).
According to the assessment of the impact on the human stool metabolome, which includes the presence of navy bean metabolites, * 26 significantly different metabolites were found at day 28 in navy bean group compared to the participants' baseline (p ≤ 0.05) and to the control group.
* Additionally, of the 560 total metabolites identified from the cooked navy beans, there were 237 possible navy bean-derived metabolites identified in the stool of participants consuming navy beans.
* Most importantly, the stool relative abundance of ophthalmic increased 5.25-fold for navy bean consumers strongly suggested that navy bean in the glutathione regulation and cancer control were attributed to detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis.
More precisely, navy-bean protects the colon cells integrity by exciting detoxed, antioxidant, anti-proliferation, and anti-apoptotic activity.
Based on the findings, researchers said, "These metabolites and metabolic pathways represent an acute response to increased navy bean intake, which merits further investigation for improving colonic health after long-term consumption".
Taken altogether, navy-bean may be considered a remedy for the improvement of colon health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(2) Dysbiosis of the gut microbiota in disease by Simon Carding,1,2 Kristin Verbeke,3 Daniel T. Vipond,1,2 Bernard M. Corfe,4,5,* andLauren J. Owen. (PMC)
Colon health is the process to enhance the function of the colon through many mechanisms, particularly, in the improvement of the ratio of gut microbiota.
Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.
Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.
In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.
Epidemiological studies suggested overweight and obese people show a dysbiosis characterized by a lower diversity. Imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.
Some researchers suggested that we can optimize our colon health by manipulating the gut microbiota through diet by increasing the intake fiber, prebiotic and probiotic foods.
Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".
And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.
On finding a natural compound for the improvement of colon health, researchers evaluated the effect of navy beans in the modulation of the host-microbiome metabolism.
The 4-week, randomized controlled trial with overweight and obese CRC survivors involved consumption of 1 meal and 1 snack daily, containing 35 g of cooked navy bean or macronutrient matched meals and snacks with 0 g of navy beans for the control group (n = 18).
According to the assessment of the impact on the human stool metabolome, which includes the presence of navy bean metabolites, * 26 significantly different metabolites were found at day 28 in navy bean group compared to the participants' baseline (p ≤ 0.05) and to the control group.
* Additionally, of the 560 total metabolites identified from the cooked navy beans, there were 237 possible navy bean-derived metabolites identified in the stool of participants consuming navy beans.
* Most importantly, the stool relative abundance of ophthalmic increased 5.25-fold for navy bean consumers strongly suggested that navy bean in the glutathione regulation and cancer control were attributed to detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis.
More precisely, navy-bean protects the colon cells integrity by exciting detoxed, antioxidant, anti-proliferation, and anti-apoptotic activity.
Based on the findings, researchers said, "These metabolites and metabolic pathways represent an acute response to increased navy bean intake, which merits further investigation for improving colonic health after long-term consumption".
Taken altogether, navy-bean may be considered a remedy for the improvement of colon health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(2) Dysbiosis of the gut microbiota in disease by Simon Carding,1,2 Kristin Verbeke,3 Daniel T. Vipond,1,2 Bernard M. Corfe,4,5,* andLauren J. Owen. (PMC)
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