Green tea may have a therapeutic and positive effect in reduced risk and treatment of hepatitis B, some scientists suggested.
Hepatitis B is a viral infection of acute and chronic liver disease, caused by a double-stranded DNA virus HBV transmitted through infected blood, semen, or other body fluid.
According to the statistic, positive carriers among Canadian is estimated to be 0.5% to 1.0%., depending on ethnicity.
According to the evaluation of the effect of green tea bioactive polyphenols epigallocatechin-3 gallate (EGCG) and risk of hepatitis B, application of the phytochemical inhibited HBV replication in the testing Hep3B2.1-7 hepatocellular carcinoma cell line, through a significant effect in reduced prevalence of liver damage caused by hepatitis B virus.
Interesting, injection of EGCG at the dose of less than 100 μM in the observed liver cancer cell line showed no effect in induced cell apoptosis and decreased proliferation but exhibited a strong effect in ameliorated expression of surface antigen of the hepatitis B virus (HBsAg) and antigen of hepatitis B virus circulated in infected blood (HBeAg) levels found by the ELISA method and the polymerase chain reaction (PCR)assay.
Further differentiation in different HepG2 2.2.15 cells to compare the effects of green tea with standard antiretroviral medication lamivudine (3TC), researchers indicated that administration of EGCG shows significant inhibition of viral proliferation through the attenuated expression of levels of HBsAg and HBeAg in the supernatant and extracellular HBV DNA in a dose- and time-dependent manner. At doses of 50-200 μg/ml EGCG displayed strong effects in compared to lamivudine (3TC) at a dose of 200 μg/ml.
More importantly, the application of EGCG also suppressed the extracellular HBV DNA, a nutrient source for viral cell proliferation and survival through attachment, aggregation, and stabilization of microcolonies.
The results of the experiments pointed out that green tea EGCG consists of a potential anti-HBV activity with low toxicity.
Additional investigation of green tea EGCG effect in the early stages of infection caused by four different Hepatitis B virus genotypes A and D also found that at dose of more than 80%, the phytochemical inhibited both DMSO-differentiated HuS-E/2 cells and HA-NTCP-expressing Huh7 cells involved cancer cell process in early stage of proliferation through induced protein degradation and ameliorated serum of transferrin.(the iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids)which is considered as a liver fibrosis biomarker in patients with chronic hepatitis B.
However, Treatment of cells with EGCG had no effect on HBV genome replication or virion secretion and the characteristic of HBV virion and the expression of known HBV entry factors were unaltered outside of the host before attacking the liver tissue.
All these results suggested that the green tea-derived molecule EGCG potently inhibits HBV entry and could be used in prevention and treatment of Hepatitis B. Intake of green tea supplement should be taken with to prevent overdoses cause of acute liver toxicity.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) (-)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes by Huang HC1, Tao MH2, Hung TM3, Chen JC4, Lin ZJ5, Huang C6.(PubMed)
(2) Preventive effects of a major component of green tea, epigallocathechin-3-gallate, on hepatitis-B virus DNA replication by Karamese M1, Aydogdu S, Karamese SA, Altoparlak U, Gundogdu C.(PubMed)
(3) Green tea polyphenol, epigallocatechin-3-gallate, possesses the antiviral activity necessary to fight against the hepatitis B virus replication in vitro by Pang JY1, Zhao KJ, Wang JB, Ma ZJ, Xiao XH.(PubMed)
Monday, August 26, 2019
Phytochemical Betanin Modulates the Production of Reactive Oxidative Species (ROS)
Reactive oxidative species or ROS are chemically reactive atoms containing oxygen
In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.
Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stable, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading a domino's effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid and cellular damage.
Believe it or not, free radical levels in a moderate amount are necessary to enhance the body functioning, including vascular relaxation.
By balancing the ratio of free radicals and antioxidant may be the best way to avoid the development of chronic illness associated with oxidative stress.
However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.
Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of irregular hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".
And, "Further, at adequate free-radical concentrations a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".
The result clearly suggested developing free-radical inhibitor may some days be used for the medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation and also aging.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot major components, on ROS production.
In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.
Furthermore, betanin did not affect the activity of caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.
In other words, betanin inhibited the free radical activity in the initiation of cytotoxicity through its antioxidant activity.
Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".
In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO, restored cellular GSH reservoirs.
Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues through stimulating the production of the antioxidant enzyme from the host.
Dr. Ahmadian E, the lead scientist wrote, "the potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered supplements for the prevention of the overexpression ROS, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The beetroot component betanin modulates ROS production, DNA damage and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)
In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.
Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stable, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading a domino's effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid and cellular damage.
Believe it or not, free radical levels in a moderate amount are necessary to enhance the body functioning, including vascular relaxation.
By balancing the ratio of free radicals and antioxidant may be the best way to avoid the development of chronic illness associated with oxidative stress.
However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.
Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of irregular hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".
And, "Further, at adequate free-radical concentrations a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".
The result clearly suggested developing free-radical inhibitor may some days be used for the medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation and also aging.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot major components, on ROS production.
In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.
Furthermore, betanin did not affect the activity of caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.
In other words, betanin inhibited the free radical activity in the initiation of cytotoxicity through its antioxidant activity.
Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".
In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.
According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO, restored cellular GSH reservoirs.
Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues through stimulating the production of the antioxidant enzyme from the host.
Dr. Ahmadian E, the lead scientist wrote, "the potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".
Taken altogether, betanin may be considered supplements for the prevention of the overexpression ROS, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The beetroot component betanin modulates ROS production, DNA damage and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)
Sunday, August 25, 2019
Green tea In Modulated Fat Metabolism
Green tea may have a therapeutic and positive effect in reduced abnormal fat metabolism, some scientists suggested.
Fat metabolism is a biological process converted lipid intake to energy for the body needs through breaking down fat into glycerol and fatty acids before being absorbed by the intestines.
In the evaluation of the mechanisms of actions of EGCG on bile acid homeostasis and lipid metabolism of green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), researchers conducted a study included male C57BL/6J mice fed with a low-fat diet, a high-fat western-style diet or a high-fat Western-style diet containing 0.32% green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), found that at 17 weeks of experiment, mice group fed with EGCG exhibits a strong effect in reduced body weight gain, mesenteric fat mass, serum cholesterol and severity of fatty liver.
Additional analysis indicated that green tea reduced expression above parameters was a result of significantly elevated the mRNA levels of cholesterol 7α-hydroxylase initiated by cholesterol in inhibition of bile acid synthesis in cholesterol metabolism, thus attenuated absorption of lipid.
Injection of green tea EGCG also increased the level of HMG-CoA reductase in inhibited cholesterol synthesis, biliary lipid secretion, and elevated blood cholesterol through activation of low-density lipoprotein receptors which play an important role of limiting step in lipid synthesis.
Moreover, green tea EGCG also elevated scavenger receptor class B type 1 (SRB1) with functions as a receptor for high-density lipoprotein in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver as well as modulating and regulating certain pathways and networks involved cellular lipids in biological systems.
Dr. Huang J, the lead scientist in the joint study at the State University of New Jersey, said, "The intestinal bile acid content was significantly decreased by EGCG, while fecal excretion of bile acids, cholesterol, and total lipids were increased" and "EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreased the absorption of lipids".
Further differentiation of the green tea effect to examine the on lipid levels associated with obesity in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks, group with green tea extract and HFD expression a significant alternation of levels of several lipid metabolites observed by the partial least squares discriminant analysis score plot.
Mice group fed with high-fat diet demonstrated decreased levels of lysophospholipids (LPLs) (lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine) which show a negative correlation with triglyceride hydrolysis and increased fat absorption in compared to normal diet group. These alternations were not found in mice group fed with HFD plus green tea.
Alternation of lysophospholipid was associated with a substantial impact on lysophospholipid metabolism, in the contribution of the onset or progression of obesity.
The restoration of lysophospholipids (LPLs) by green tea extract caused by long term high-fat diet may be an indication of how green tea reduced expression of inflammation, insulin resistance, and fatty liver disease in obesity.
Interestingly, in the observation of injection of green tea extract in the regulation of hepatic fat metabolism in 36 male chickens fed GTPs at a daily dose of 0, 80 or 160 mg/kg of body weight for 4 weeks, researchers at the joint study lead by the Anhui Agricultural University, suggested that oral administration of green tea polyphenols (GTPs) significantly improves lipid metabolism through reduced hepatic lipid content and abdominal fat mass and abdominal fat mass accumulation which were correlated to onset and progression of overweight and obesity.
Additionally, the application also expressed a strong effect in the phosphorylation levels of AMP-activated protein kinase α (AMPKα) which play an important role in skeletal muscle fatty acid utilization and in regulating growth and reprogramming metabolism, and Acetyl-CoA carboxylase 1 (ACACA) in modulation of fat cell cycle stages and cytokinesis, thus reducing fat synthesis and production of pro-inflammatory cytokines.
More importantly, green tea polyphenol also altered the mRNA levels and enzymatic activities in the suppressed expression of enzymes involved PUFA in the liver in stimulated lipid synthesis and fat oxidation.
Taken together, green tea containing a high amount of bioactive polyphenols, such as catechins may be considered as a functional food to reduce the onset and progression of overweight and obesity. However, the intake of green tea extract should be taken with care as acute liver toxicity has been reported in some cases.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice by Huang J1,2, Feng S1,3, Liu A1, Dai Z1,4, Wang H1, Reuhl K5, Lu W6, Yang CS1,2.(PubMed)
(2) Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet by Nam M1, Choi MS2, Choi JY2, Kim N3, Kim MS3, Jung S1, Kim J1, Ryu DH4, Hwang GS5.(PubMed)
(3) Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase by Huang J1,2, Zhou Y1, Wan B1, Wang Q1, Wan X1,2.(PubMed)
(4) Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats by Yamauchi S1, Linscheer WG, Beach DH.(PubMed)
Fat metabolism is a biological process converted lipid intake to energy for the body needs through breaking down fat into glycerol and fatty acids before being absorbed by the intestines.
In the evaluation of the mechanisms of actions of EGCG on bile acid homeostasis and lipid metabolism of green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), researchers conducted a study included male C57BL/6J mice fed with a low-fat diet, a high-fat western-style diet or a high-fat Western-style diet containing 0.32% green tea bioactive polyphenol (-)-epigallocatechin-3-gallate (EGCG), found that at 17 weeks of experiment, mice group fed with EGCG exhibits a strong effect in reduced body weight gain, mesenteric fat mass, serum cholesterol and severity of fatty liver.
Additional analysis indicated that green tea reduced expression above parameters was a result of significantly elevated the mRNA levels of cholesterol 7α-hydroxylase initiated by cholesterol in inhibition of bile acid synthesis in cholesterol metabolism, thus attenuated absorption of lipid.
Injection of green tea EGCG also increased the level of HMG-CoA reductase in inhibited cholesterol synthesis, biliary lipid secretion, and elevated blood cholesterol through activation of low-density lipoprotein receptors which play an important role of limiting step in lipid synthesis.
Moreover, green tea EGCG also elevated scavenger receptor class B type 1 (SRB1) with functions as a receptor for high-density lipoprotein in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver as well as modulating and regulating certain pathways and networks involved cellular lipids in biological systems.
Dr. Huang J, the lead scientist in the joint study at the State University of New Jersey, said, "The intestinal bile acid content was significantly decreased by EGCG, while fecal excretion of bile acids, cholesterol, and total lipids were increased" and "EGCG decreases bile acid reabsorption, results in lower intestinal bile acid levels, which further decreased the absorption of lipids".
Further differentiation of the green tea effect to examine the on lipid levels associated with obesity in C57BL/6J mice fed a normal diet (ND), HFD and HFD with GT for 12 weeks, group with green tea extract and HFD expression a significant alternation of levels of several lipid metabolites observed by the partial least squares discriminant analysis score plot.
Mice group fed with high-fat diet demonstrated decreased levels of lysophospholipids (LPLs) (lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine) which show a negative correlation with triglyceride hydrolysis and increased fat absorption in compared to normal diet group. These alternations were not found in mice group fed with HFD plus green tea.
Alternation of lysophospholipid was associated with a substantial impact on lysophospholipid metabolism, in the contribution of the onset or progression of obesity.
The restoration of lysophospholipids (LPLs) by green tea extract caused by long term high-fat diet may be an indication of how green tea reduced expression of inflammation, insulin resistance, and fatty liver disease in obesity.
Interestingly, in the observation of injection of green tea extract in the regulation of hepatic fat metabolism in 36 male chickens fed GTPs at a daily dose of 0, 80 or 160 mg/kg of body weight for 4 weeks, researchers at the joint study lead by the Anhui Agricultural University, suggested that oral administration of green tea polyphenols (GTPs) significantly improves lipid metabolism through reduced hepatic lipid content and abdominal fat mass and abdominal fat mass accumulation which were correlated to onset and progression of overweight and obesity.
Additionally, the application also expressed a strong effect in the phosphorylation levels of AMP-activated protein kinase α (AMPKα) which play an important role in skeletal muscle fatty acid utilization and in regulating growth and reprogramming metabolism, and Acetyl-CoA carboxylase 1 (ACACA) in modulation of fat cell cycle stages and cytokinesis, thus reducing fat synthesis and production of pro-inflammatory cytokines.
More importantly, green tea polyphenol also altered the mRNA levels and enzymatic activities in the suppressed expression of enzymes involved PUFA in the liver in stimulated lipid synthesis and fat oxidation.
Taken together, green tea containing a high amount of bioactive polyphenols, such as catechins may be considered as a functional food to reduce the onset and progression of overweight and obesity. However, the intake of green tea extract should be taken with care as acute liver toxicity has been reported in some cases.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice by Huang J1,2, Feng S1,3, Liu A1, Dai Z1,4, Wang H1, Reuhl K5, Lu W6, Yang CS1,2.(PubMed)
(2) Effect of green tea on hepatic lipid metabolism in mice fed a high-fat diet by Nam M1, Choi MS2, Choi JY2, Kim N3, Kim MS3, Jung S1, Kim J1, Ryu DH4, Hwang GS5.(PubMed)
(3) Green tea polyphenols alter lipid metabolism in the livers of broiler chickens through increased phosphorylation of AMP-activated protein kinase by Huang J1,2, Zhou Y1, Wan B1, Wang Q1, Wan X1,2.(PubMed)
(4) Increase in serum and bile cholesterol and HMG-CoA reductase by lovastatin in rats by Yamauchi S1, Linscheer WG, Beach DH.(PubMed)
Healthy Food Tomato Protects The Integrity of Neurons Against Neurological Disorders in Vivo
Neurological disorders are class of diseases associated with the brain, the spinal cord including the nerves that connect them.
Most common diseases of neurological disorders are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.
Back pain associated with the related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen on post-stroke patients, difficulty reading and writing and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient for the treatment of neurological inflammatory disease, researchers examined phytochemical lycopene isolated from tomatoes against experimental Parkinson's disease (PD).
The study included PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oral administration of different doses (5, 10 and 20 mg/kg/day).
All doses showed a strong effect in protecting MPTP induced depletion of striatal dopamine (DA) and its metabolites in a dose-dependent manner.
Application of all doses also attenuated MPTP-induced oxidative stress and motor abnormalities in mice treated with MPTP.
Furthermore, according to the western blot assay, lycopene protected the neurons against MPTP induced apoptosis through its antioxidant and antiapoptotic properties.
In other words, lycopene in different doses exerted a PD protective activity by restoring the neurochemicals, neuron apoptosis caused by overexpression of free radicals.
Based on the findings, researchers said, " lycopene reverses neurochemical deficits, oxidative stress, apoptosis and physiological abnormalities in PD mice and offers promise strategy in the treatment of this neurodegenerative disease".
Moreover, in Alzheimer's disease (AD), associated with neuroinflammation characterized by glial activation and release of proinflammatory mediators, researchers examined the efficacy of lycopene against β-Amyloid1-42 (Aβ1-42)-induced learning and memory impairment in an animal model.
In selected induced Aβ1-42 bilaterally followed by treatment with lycopene or rivastigmine for 14 days, lycopene remediated Aβ-induced learning and memory deficits in a dose-dependent manner.
Additionally, lycopene treated group showed to ameliorate the side effects of Aβ1-42-induced mitochondrial dysfunction along with a surge of proinflammatory cytokines (TNF-α, TGF-β, and IL-1β) and protein associated with inflammatory signaling and neuron apoptosis.
Dr. Sachdeva AK, the lead scientist after taking other factors into account, wrote, "The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment".
Taken altogether, tomatoes processed abundantly bioactive ingredient lycopene may be considered supplements for the prevention and treatment of angiotensin caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice by Prema A1, Janakiraman U1, Manivasagam T2, Thenmozhi AJ. (PubMed)
(2) Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease by Sachdeva AK1, Chopra K. (PubMed)
(3) Neurological Problem Symptoms, Causes, and Effects by the American Addiction Center
Most common diseases of neurological disorders are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.
Back pain associated with the related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen on post-stroke patients, difficulty reading and writing and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient for the treatment of neurological inflammatory disease, researchers examined phytochemical lycopene isolated from tomatoes against experimental Parkinson's disease (PD).
The study included PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oral administration of different doses (5, 10 and 20 mg/kg/day).
All doses showed a strong effect in protecting MPTP induced depletion of striatal dopamine (DA) and its metabolites in a dose-dependent manner.
Application of all doses also attenuated MPTP-induced oxidative stress and motor abnormalities in mice treated with MPTP.
Furthermore, according to the western blot assay, lycopene protected the neurons against MPTP induced apoptosis through its antioxidant and antiapoptotic properties.
In other words, lycopene in different doses exerted a PD protective activity by restoring the neurochemicals, neuron apoptosis caused by overexpression of free radicals.
Based on the findings, researchers said, " lycopene reverses neurochemical deficits, oxidative stress, apoptosis and physiological abnormalities in PD mice and offers promise strategy in the treatment of this neurodegenerative disease".
Moreover, in Alzheimer's disease (AD), associated with neuroinflammation characterized by glial activation and release of proinflammatory mediators, researchers examined the efficacy of lycopene against β-Amyloid1-42 (Aβ1-42)-induced learning and memory impairment in an animal model.
In selected induced Aβ1-42 bilaterally followed by treatment with lycopene or rivastigmine for 14 days, lycopene remediated Aβ-induced learning and memory deficits in a dose-dependent manner.
Additionally, lycopene treated group showed to ameliorate the side effects of Aβ1-42-induced mitochondrial dysfunction along with a surge of proinflammatory cytokines (TNF-α, TGF-β, and IL-1β) and protein associated with inflammatory signaling and neuron apoptosis.
Dr. Sachdeva AK, the lead scientist after taking other factors into account, wrote, "The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment".
Taken altogether, tomatoes processed abundantly bioactive ingredient lycopene may be considered supplements for the prevention and treatment of angiotensin caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice by Prema A1, Janakiraman U1, Manivasagam T2, Thenmozhi AJ. (PubMed)
(2) Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease by Sachdeva AK1, Chopra K. (PubMed)
(3) Neurological Problem Symptoms, Causes, and Effects by the American Addiction Center
Saturday, August 24, 2019
Phytochemical Alliin Inhibits the Onset of Neuro-Degenerative Diseases in Vitro
Neuroprotection is an action induced the preservation of neuronal structure and/or function, including the use of medicines and herbs.
In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time, particularly in neurodegenerative disease.
Neurodegenerative disease is the class of condition associated with the progressive loss of neuron occurred mostly in older adults, including dementia, with the most common being Alzheimer`s disease (AD).
According to the statistic, dementia affects over 47.5 million people worldwide, approximately 58 percent are living within low and middle-income countries.
Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019 and two-thirds of people with Alzheimer's disease are women.
Conventionally, there is no cure for dementia. The purpose of the medications that are used for the treatment of dementia is to improve dementia symptoms and slow down the progression of the disease.
Some researchers concern that Alzheimer's disease in people younger than the age of 60 was up 5 percent over the past few decades may be correlated to the promotion of a high-fat diet in the US.
Dr. Ruan Y, the lead scientist wrote, "A higher dietary saturated fat intake was significantly associated with an increased risk of 39% and 105% for AD (RR: 1.39; 95% CI: 1.00, 1.94) and dementia (RR: 2.05; 95% CI: 1.06, 3.98), respectively".
And, "Dose-response analysis indicated a 4 g/day increment of saturated fat intake was related to 15% higher risk of AD (RR: 1.15; 95% CI: 1.01, 1.31)".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In the urgency to discover a natural and potential compound for the treatment of neurodegenerative disease, scientists examined the alliin neuroprotective activity.
In vitro, alliin exerted a significant effect to protect neuronal cells integrity and viability against beta-amyloid (A) toxicity and apoptosis.
Furthermore, also in vitro, alliin inhibited oxidative stress caused by overexpression of reactive oxygen species (ROS) in cells in facilitating several neurodegenerative diseases including Alzheimer's disease (AD).
In lipopolysaccharide- (LPS-) stimulated 3T3-L1 used in biological research on adipose tissue, incubation in a period of 24 h together with 100 μmol/L alliin, alliin prevented the increase of proinflammatory cytokines in the liver, muscle, heart and brain cells through its antioxidant activity.
The inhibition of inflammation of alliin was attributed to the decreased expression of the ERK1/2 pathway involved in the expression of oxidative stress and inflammation.
In other words, alliin protects the brain cells by suppressing the LPS inflammatory signals by generating an anti-inflammatory gene expression.
Taken altogether, alliin may be considered supplements for the neuroprotection, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective Effects of Garlic A Review by BC Mathew and RS Biju. (PubMed)
(2) Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes by Quintero-Fabián S1, Ortuño-Sahagún D2, Vázquez-Carrera M3, López-Roa RI. (PubMed)
(3) Dietary Fat Intake and Risk of Alzheimer's Disease and Dementia: A Meta-Analysis of Cohort Studies by bRuan Y1, Tang J1, Guo X1, Li K2, Li D. (PubMed)
In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time, particularly in neurodegenerative disease.
Neurodegenerative disease is the class of condition associated with the progressive loss of neuron occurred mostly in older adults, including dementia, with the most common being Alzheimer`s disease (AD).
According to the statistic, dementia affects over 47.5 million people worldwide, approximately 58 percent are living within low and middle-income countries.
Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019 and two-thirds of people with Alzheimer's disease are women.
Conventionally, there is no cure for dementia. The purpose of the medications that are used for the treatment of dementia is to improve dementia symptoms and slow down the progression of the disease.
Some researchers concern that Alzheimer's disease in people younger than the age of 60 was up 5 percent over the past few decades may be correlated to the promotion of a high-fat diet in the US.
Dr. Ruan Y, the lead scientist wrote, "A higher dietary saturated fat intake was significantly associated with an increased risk of 39% and 105% for AD (RR: 1.39; 95% CI: 1.00, 1.94) and dementia (RR: 2.05; 95% CI: 1.06, 3.98), respectively".
And, "Dose-response analysis indicated a 4 g/day increment of saturated fat intake was related to 15% higher risk of AD (RR: 1.15; 95% CI: 1.01, 1.31)".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In the urgency to discover a natural and potential compound for the treatment of neurodegenerative disease, scientists examined the alliin neuroprotective activity.
In vitro, alliin exerted a significant effect to protect neuronal cells integrity and viability against beta-amyloid (A) toxicity and apoptosis.
Furthermore, also in vitro, alliin inhibited oxidative stress caused by overexpression of reactive oxygen species (ROS) in cells in facilitating several neurodegenerative diseases including Alzheimer's disease (AD).
In lipopolysaccharide- (LPS-) stimulated 3T3-L1 used in biological research on adipose tissue, incubation in a period of 24 h together with 100 μmol/L alliin, alliin prevented the increase of proinflammatory cytokines in the liver, muscle, heart and brain cells through its antioxidant activity.
The inhibition of inflammation of alliin was attributed to the decreased expression of the ERK1/2 pathway involved in the expression of oxidative stress and inflammation.
In other words, alliin protects the brain cells by suppressing the LPS inflammatory signals by generating an anti-inflammatory gene expression.
Taken altogether, alliin may be considered supplements for the neuroprotection, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective Effects of Garlic A Review by BC Mathew and RS Biju. (PubMed)
(2) Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes by Quintero-Fabián S1, Ortuño-Sahagún D2, Vázquez-Carrera M3, López-Roa RI. (PubMed)
(3) Dietary Fat Intake and Risk of Alzheimer's Disease and Dementia: A Meta-Analysis of Cohort Studies by bRuan Y1, Tang J1, Guo X1, Li K2, Li D. (PubMed)
Green Tea In Ameliorated Risk, Progression and Treatment of Liver Fibrosis
Green tea may have a therapeutic and positive effect in reduced risk and treatment of Liver Fibrosis, some scientists suggested.
Green tea containing more amount of antioxidants than any drink or food with the same volume is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Liver fibrosis is a liver disease with excessive accumulation of scar tissue as a result of inflammation and liver cell death
According to Fibro Test, approximately, the prevalence of advanced fibrosis was 2.8% in a general population aged 40 years or older.
According to the application of a novel bio-nano particle named 'Chitosan nano-encapsulated green tea extract' at the ultrastructural level on 25 adult rats induced liver toxicity by injection of carbon-tetrachloride and ethanol doses for 3 weeks, rats treated with novel substance expressed a significant reduction of nearly 25% of the sub-cellular area infected with hepatic fibrosis.
The efficacy of Chitosan nano-encapsulated green tea extract in decreased liver fibroids was attributed to the antioxidant activity in inhibited the expression of the injected chemicals in induction overproduction of reactive oxygen species (ROS) in a chain reaction to elevated oxidative stress in the initiation of liver cell apoptosis.
Observed by scanning electron microscopy, oral administration of novel bio-nano particle also exerted a strong free radical scavengers effect in protected against changes of cell surface structure and surrounding area between the hepatocytes, thus ameliorated risk of collagen deposit to cause liver fibroids.
Moreover, in carbon tetrachloride CCL4 induced fibrotic liver tissues in rat models, treatment of Green Tea Extract (GTE) encapsulated into Chitosan Nanoparties (CS-NPs) revealed that collagen fibers of 250 to 300 nm widths found in the fibrotic liver samples of the control group with no treatment were cleared in the green tea treatment group.
The effectiveness of GTE is a reduced expression of collagen fibers in the liver a was found to correlate to the antioxidant expression in reduced CCL4 in the induction of overproduction of free radicals in precipitated liver tissue damage.
Interestingly, in the evaluation of the protective effect of green tea extract (GT) on hepatic fibrosis in vitro and in vivo in dimethylnitrosamine (DMN)-induced rats, researchers at the Korea University, indicated that application of GT inhibited activated HSC-T6, a rat hepatic stellate cell line which is considered as the major cell type involved in liver fibrosis.
The application also attenuated the collagen deposition which are elevated and acted as a biomaker for progression of liver fibrosis, particularly, in expression of collagen type 1 formation of scar tissue in response to liver damage, found in the early event in the development of hepatic fibrosis, confirmed both by liver histology and by quantitative measurement of hepatic hydroxyproline content.
Dr. Kim HK, the lead author said, "green tea administration can effectively improve liver fibrosis caused by DMN, and may be used as a therapeutic option and preventive measure against hepatic fibrosis".
Taken together, green tea with abundant bioactive polyphenols may have a therapeutic and pharmaceutical effect in reduced risk, progression, and treatment of liver fibroid caused by forming of scars as a result of liver damage through antioxidant activity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Green Tea Extract Encapsulated Into Chitosan Nanoparticles on Hepatic FibrosisCollagen Fibers Assessed by Atomic Force Microscopy in Rat Hepatic Fibrosis Model by Safer AM, Hanafy NA, Bharali DJ, Cui H, Mousa SA.(PubMed)
(2) Quantification of the Healing Effect in Hepatic Fibrosis Induced by Chitosan Nano-Encapsulated Green Tea in Rat Model by Safer AM, Sen A, Hanafy NA, Mousa SA.(PubMed)
(3) Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis by Kim HK1, Yang TH, Cho HY.(PubMed)
Green tea containing more amount of antioxidants than any drink or food with the same volume is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Liver fibrosis is a liver disease with excessive accumulation of scar tissue as a result of inflammation and liver cell death
According to Fibro Test, approximately, the prevalence of advanced fibrosis was 2.8% in a general population aged 40 years or older.
According to the application of a novel bio-nano particle named 'Chitosan nano-encapsulated green tea extract' at the ultrastructural level on 25 adult rats induced liver toxicity by injection of carbon-tetrachloride and ethanol doses for 3 weeks, rats treated with novel substance expressed a significant reduction of nearly 25% of the sub-cellular area infected with hepatic fibrosis.
The efficacy of Chitosan nano-encapsulated green tea extract in decreased liver fibroids was attributed to the antioxidant activity in inhibited the expression of the injected chemicals in induction overproduction of reactive oxygen species (ROS) in a chain reaction to elevated oxidative stress in the initiation of liver cell apoptosis.
Observed by scanning electron microscopy, oral administration of novel bio-nano particle also exerted a strong free radical scavengers effect in protected against changes of cell surface structure and surrounding area between the hepatocytes, thus ameliorated risk of collagen deposit to cause liver fibroids.
Moreover, in carbon tetrachloride CCL4 induced fibrotic liver tissues in rat models, treatment of Green Tea Extract (GTE) encapsulated into Chitosan Nanoparties (CS-NPs) revealed that collagen fibers of 250 to 300 nm widths found in the fibrotic liver samples of the control group with no treatment were cleared in the green tea treatment group.
The effectiveness of GTE is a reduced expression of collagen fibers in the liver a was found to correlate to the antioxidant expression in reduced CCL4 in the induction of overproduction of free radicals in precipitated liver tissue damage.
Interestingly, in the evaluation of the protective effect of green tea extract (GT) on hepatic fibrosis in vitro and in vivo in dimethylnitrosamine (DMN)-induced rats, researchers at the Korea University, indicated that application of GT inhibited activated HSC-T6, a rat hepatic stellate cell line which is considered as the major cell type involved in liver fibrosis.
The application also attenuated the collagen deposition which are elevated and acted as a biomaker for progression of liver fibrosis, particularly, in expression of collagen type 1 formation of scar tissue in response to liver damage, found in the early event in the development of hepatic fibrosis, confirmed both by liver histology and by quantitative measurement of hepatic hydroxyproline content.
Dr. Kim HK, the lead author said, "green tea administration can effectively improve liver fibrosis caused by DMN, and may be used as a therapeutic option and preventive measure against hepatic fibrosis".
Taken together, green tea with abundant bioactive polyphenols may have a therapeutic and pharmaceutical effect in reduced risk, progression, and treatment of liver fibroid caused by forming of scars as a result of liver damage through antioxidant activity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Green Tea Extract Encapsulated Into Chitosan Nanoparticles on Hepatic FibrosisCollagen Fibers Assessed by Atomic Force Microscopy in Rat Hepatic Fibrosis Model by Safer AM, Hanafy NA, Bharali DJ, Cui H, Mousa SA.(PubMed)
(2) Quantification of the Healing Effect in Hepatic Fibrosis Induced by Chitosan Nano-Encapsulated Green Tea in Rat Model by Safer AM, Sen A, Hanafy NA, Mousa SA.(PubMed)
(3) Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis by Kim HK1, Yang TH, Cho HY.(PubMed)
Friday, August 23, 2019
Green Tea in Reduced Risk of Gut Microbiota Imbalance in Induction of Obesity and Gastrointestinal Diseases
Green tea may have a therapeutic and positive effect in improved microbiota imbalance in Induction of obesity and gastrointestinal diseases, some scientists suggested.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Gut microbiota is microorganisms that lived in the digestive tracts in humans and animals.
According to the evaluation of obesity-induced of C57BL/6 J male mice by feeding a high fat (HF) diet for 8 weeks, followed by treatment with oral tea saponin (0.5%) mixed in HF diet for a further 6 weeks, injection of tea saponin (0.5%) mice demonstrated a impressive activity in ameliorated endotoxemia which cause by accumulation of endotoxins in the blood, an indication of overproduction of gram-negative rod-shaped bacteria, reduced numbers of pro-inflammatory macrophage accumulation in the colon in exhibited colon inflammation and gut microbiota alterations in reduced expression of good bacteria, such as Bifidobacteria, Lactobacillus,... and overexpression of harmful bacteria Escherichia Coli and Enterobacter caused by HF diet.
Patients with digestive disorders have been found to associate to an imbalance of gut microbiota and dysbiosis of the gut bacteria communities that can lead to many chronic issues and diseases, including irritable bowel syndrome (IBS), coeliac disease, inflammatory bowel disease, obesity, colon cancer, and autism......,
In fact, balancing of gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet and dysfunction of the community is associated various causes in the induction of obesity and malnutrition.
According to the study, tea saponin also improved glucose tolerance and reduced body weight gain in HF diet-induced obese mice that may be an expression of green tea extract in limit unfavorable gut microbiota alterations in HF diet-induced obesity.
Additional analysis of oral administration of three types of tea infusions for 13 weeks in high-fat-diet-induced obese C57BL/6J mice to examine their anti-obesity and gut microbiota modulatory effects. suggested that the application of the tea infusion showed a strong effect in the prevention of the development of obesity with no significant differences and expressed a substantially increased diversity and altered the structure of gut microbiota in tested mice.
According to the high-throughput MiSeq sequencing, multivariate statistical and linear discriminant assays, Dr. Liu Z, the lead author at the Fuzhou University said, "tea infusion consumption substantially increased diversity and altered the structure of gut microbiota" and "(Some) key phylotypes (such as Alistipes, Rikenella, Lachnospiraceae, Akkermansia, Bacteroides,...) might have a close association with the obesity-related indexes of the host".
Interestingly, in male Swiss albino mice were fed with HFD (58% fat kcal) induced alterations of gut microbiota for 12 weeks, green tea extract (GTE) and isomalto-oligosaccharide (IMOs), a naturally occurring plant-based dietary injection, significantly improved liver metabolome associated with lipid metabolism and prevented imbalance of gut microbiota in damage of the lining of the small intestine (leaky gut), through reduced expression of lipopolysaccharides(LPS) in the bloodstream(an indication of serve inflammation) and pro-inflammatory cytokines (e.g. resistin, TNF-α, and IL-1β).
Dr. Singh DP, the lead scientist at the University Institute of Pharmaceutical Sciences (UIPS) after differentiating above illustration said, " Combination (of GTE and IMOs restores the balance of gut microbiota through), improved beneficial gut microbiota (Lactobacillus sp., Bifidobacteria, Akkermansia muciniphila, Roseburia spp.) abundances, restored Firmicutes/Bacteriodetes and improved Prevotella/Bacteroides proportions".
Taking all together, green tea and its phytochemical constituents expressed strongly improved beneficial effects on multiple parameters in maintaining the favorable gut microbiota ratio in reduced risk of the onset of certain diseases, including obesity, celiac disease, inflammatory bowel disease.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice by Wang S1,2, Huang XF3,4, Zhang P1,5, Newell KA1, Wang H1, Zheng K5, Yu Y6,7.(PubMed)
(2) The modulatory effect of infusions of green tea, oolong tea, and black tea on gut microbiota in high-fat-induced obese mice by Liu Z1, Chen Z1, Guo H1, He D1, Zhao H1, Wang Z1, Zhang W1, Liao L1, Zhang C1, Ni L1.(PubMed)
(3) Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice by Singh DP1, Singh J2, Boparai RK3, Zhu J4, Mantri S2, Khare P1, Khardori R5, Kondepudi KK6, Chopra K7, Bishnoi M8.(PubMed)
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Gut microbiota is microorganisms that lived in the digestive tracts in humans and animals.
According to the evaluation of obesity-induced of C57BL/6 J male mice by feeding a high fat (HF) diet for 8 weeks, followed by treatment with oral tea saponin (0.5%) mixed in HF diet for a further 6 weeks, injection of tea saponin (0.5%) mice demonstrated a impressive activity in ameliorated endotoxemia which cause by accumulation of endotoxins in the blood, an indication of overproduction of gram-negative rod-shaped bacteria, reduced numbers of pro-inflammatory macrophage accumulation in the colon in exhibited colon inflammation and gut microbiota alterations in reduced expression of good bacteria, such as Bifidobacteria, Lactobacillus,... and overexpression of harmful bacteria Escherichia Coli and Enterobacter caused by HF diet.
Patients with digestive disorders have been found to associate to an imbalance of gut microbiota and dysbiosis of the gut bacteria communities that can lead to many chronic issues and diseases, including irritable bowel syndrome (IBS), coeliac disease, inflammatory bowel disease, obesity, colon cancer, and autism......,
In fact, balancing of gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet and dysfunction of the community is associated various causes in the induction of obesity and malnutrition.
According to the study, tea saponin also improved glucose tolerance and reduced body weight gain in HF diet-induced obese mice that may be an expression of green tea extract in limit unfavorable gut microbiota alterations in HF diet-induced obesity.
Additional analysis of oral administration of three types of tea infusions for 13 weeks in high-fat-diet-induced obese C57BL/6J mice to examine their anti-obesity and gut microbiota modulatory effects. suggested that the application of the tea infusion showed a strong effect in the prevention of the development of obesity with no significant differences and expressed a substantially increased diversity and altered the structure of gut microbiota in tested mice.
According to the high-throughput MiSeq sequencing, multivariate statistical and linear discriminant assays, Dr. Liu Z, the lead author at the Fuzhou University said, "tea infusion consumption substantially increased diversity and altered the structure of gut microbiota" and "(Some) key phylotypes (such as Alistipes, Rikenella, Lachnospiraceae, Akkermansia, Bacteroides,...) might have a close association with the obesity-related indexes of the host".
Interestingly, in male Swiss albino mice were fed with HFD (58% fat kcal) induced alterations of gut microbiota for 12 weeks, green tea extract (GTE) and isomalto-oligosaccharide (IMOs), a naturally occurring plant-based dietary injection, significantly improved liver metabolome associated with lipid metabolism and prevented imbalance of gut microbiota in damage of the lining of the small intestine (leaky gut), through reduced expression of lipopolysaccharides(LPS) in the bloodstream(an indication of serve inflammation) and pro-inflammatory cytokines (e.g. resistin, TNF-α, and IL-1β).
Dr. Singh DP, the lead scientist at the University Institute of Pharmaceutical Sciences (UIPS) after differentiating above illustration said, " Combination (of GTE and IMOs restores the balance of gut microbiota through), improved beneficial gut microbiota (Lactobacillus sp., Bifidobacteria, Akkermansia muciniphila, Roseburia spp.) abundances, restored Firmicutes/Bacteriodetes and improved Prevotella/Bacteroides proportions".
Taking all together, green tea and its phytochemical constituents expressed strongly improved beneficial effects on multiple parameters in maintaining the favorable gut microbiota ratio in reduced risk of the onset of certain diseases, including obesity, celiac disease, inflammatory bowel disease.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice by Wang S1,2, Huang XF3,4, Zhang P1,5, Newell KA1, Wang H1, Zheng K5, Yu Y6,7.(PubMed)
(2) The modulatory effect of infusions of green tea, oolong tea, and black tea on gut microbiota in high-fat-induced obese mice by Liu Z1, Chen Z1, Guo H1, He D1, Zhao H1, Wang Z1, Zhang W1, Liao L1, Zhang C1, Ni L1.(PubMed)
(3) Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice by Singh DP1, Singh J2, Boparai RK3, Zhu J4, Mantri S2, Khare P1, Khardori R5, Kondepudi KK6, Chopra K7, Bishnoi M8.(PubMed)
Subscribe to:
Posts (Atom)