Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle. Depending on the location of heart muscle damage or the blood vessel blockage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart.
Heart failure, a major health problem associated with the reduced function of the heart, is a leading cause of hospitalization in people older than age 65. Believe it or not, more than 6.5 million Americans are living with the condition of heart failure.
According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the US. More precisely, 1 in every 4 deaths in the US every year are caused by heart disease.
Furthermore, every year about 735,000 Americans has a heart attack including the first attack of 525,000 patients.
The exact causes of cardiovascular disease are not cleared. However, epidemiologically family history, age ethnicity, gender, medical conditions such as cholesterol high blood pressure and diabetes has been found in most patients with CVD.
Some researchers in the examined the correlation between a high-fat diet and cardiovascular disease in obese patients suggested that the promotion of a high-fat diet over the past few decades may be one major culprit that causes the onset of CVD.
Dr. Jane E Freedman wrote, " According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease.".
And, " clearly established diseases associated with high-fat or high-calorie diets can be offset by the use of nutritional supplements. Although these findings beckon us to draw broader implications, even if proven true in larger studies, it is doubtful that this will lead to a recommendation of high-calorie, high-fat diets".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
On finding a natural compound for the prevention of cardiovascular disease, researchers examined the effect of lycopene by a meta-analysis.
According to the 14 studies identified by the search in the medical literature of the database of Pubmed, Embase, and Web of Science from inception to October 2016,* Lycopene exerted a significant inverse association with a pooled risk ratio (RR) of 0.83 in the risk of CVD.
* Furthermore, dietary lycopene intake was statistically significant in the reduction of risk of coronary heart disease (CHD) with an RR of 0.87 and stroke with an RR of 0.83.
* Lycopene biomarker concentrations were also inversely associated with the risk CVD.
Based on the findings, researchers wrote in the final report, "Higher lycopene exposure is inversely associated with a lower risk of CVD".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of CVD, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Deficiency in Ageing and Cardiovascular Disease by Petyaev IM. (PubMed)
(2) Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies by Song B1, Liu K1, Gao Y1, Zhao L1, Fang H1, Li Y1, Pei L1, Xu Y. (PubMed)
(2) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (JACC Journals)
Sunday, September 1, 2019
Saturday, August 31, 2019
Healthy Food Onion Inhibits the Initiation and Progression of Gastrointestinal Tract Cancer
Digestive cancer is a group of medical conditions associated with irregular cell growth in the tissue on the gastrointestinal tract.
Most cases of gastrointestinal cancer begin in the cells on the surface of the inner lining in a specific organ, before penetrating into deeper layers to form a solid tumor through proliferation.
Most common cancers of the gastrointestinal tract are
*Esophagus
The esophagus or gullet is the tube that leads foods from the pharynx to the stomach.
Esophageal cancer is caused by abnormal cell growth in the cells that line the upper part of the esophagus or glandular cells in the lower part of the esophagus that connected with the stomach.
Esophageal cancer starts from the lining of the esophagus, then later penetrate in the wall of the esophagus and spread to the lymph node around the bottom of the esophagus, stomach and the chest.
* Gallbladder cancer
The gallbladder is a small organ under the liver with a function that aids the digestive system in fat metabolism with storing bile produced by the liver.
Gallbladder cancer arises from the cells of the tissue of the gallbladder. It is common cancer in central and South America, central and eastern Europe, Japan and northern India, but rare in North America.
*Liver cancer
The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above the stomach.
Liver cancer is a condition caused by the uncontrolled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most cases of liver cancer are diagnosed in the later stage of cancer.
According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
*Pancreas cancer pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen.
By secreting pancreatic juice to the small intestine, pancreas helps to break down carbohydrates, proteins, and lipids.
Cancer of pancreas or pancreatic cancer is a chronic condition associated with irregular cell growth in the ducts (an exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue which accounts for over 75 - 90% of all cases of exocrine cancers.
*Stomach cancer
Stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.
Stomach cancer is a condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
* Bowel cancer
Human Bowl is divided into 2 parts, the small bowel, is associated with the digestion and absorption of food. large bowel including the colon and rectum that involve absorption of water from the small bowel contents and break down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Bowel cancer is a condition caused by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix.
Bowel cancer is relatively very common and slowly growing and progressing in a predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including the US and Canada.
Besides some of the symptoms associated with specific types of cancer, most gastrointestinal cancers shared the general symptoms of unintended weight loss, loss of appetite, fatigue, nausea, and vomiting.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the treatment of cancer in the digestive system, researchers examined the relationship between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).
According to the results of data of published observational studies (21 case-control and four cohort studies), using a meta-analytic approach and random effects models, onion exerted the relative risk of 0.72 compared to 0.79 for total allium, 0.74 for garlic for the highest versus the lowest consumption.
Total allium including onion consumption showed an inverse relation apparently stronger in case-control studies.
These results suggested that onion has a moderate inverse association with the risk of squamous cell carcinoma of the UADT.
Additionally, according to the University Laboratories of Medical Research (LURM) in the examination of the effects of dietary components on cancer of the digestive system, onion contains active components that can influence the initiation and progression of cancer.
Furthermore, these chemical compounds have also been found to inhibit cell proliferation and metastasis, induce apoptosis.
More precisely, onion protected the integrity and viability of the cells in the digestive system through it's antioxidant, cytotoxic, and pro-apoptotic properties.
Taken altogether, onion may be considered a remedy for the prevention and treatment of cancer of the digestive system, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of dietary components on cancer of the digestive system by Zanini S1, Marzotto M, Giovinazzo F, Bassi C, Bellavite P. (PubMed)
(2) Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies by Guercio V1, Turati F2, La Vecchia C1, Galeone C2, Tavani A. (PubMed)
Most cases of gastrointestinal cancer begin in the cells on the surface of the inner lining in a specific organ, before penetrating into deeper layers to form a solid tumor through proliferation.
Most common cancers of the gastrointestinal tract are
*Esophagus
The esophagus or gullet is the tube that leads foods from the pharynx to the stomach.
Esophageal cancer is caused by abnormal cell growth in the cells that line the upper part of the esophagus or glandular cells in the lower part of the esophagus that connected with the stomach.
Esophageal cancer starts from the lining of the esophagus, then later penetrate in the wall of the esophagus and spread to the lymph node around the bottom of the esophagus, stomach and the chest.
* Gallbladder cancer
The gallbladder is a small organ under the liver with a function that aids the digestive system in fat metabolism with storing bile produced by the liver.
Gallbladder cancer arises from the cells of the tissue of the gallbladder. It is common cancer in central and South America, central and eastern Europe, Japan and northern India, but rare in North America.
*Liver cancer
The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above the stomach.
Liver cancer is a condition caused by the uncontrolled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most cases of liver cancer are diagnosed in the later stage of cancer.
According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
*Pancreas cancer pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen.
By secreting pancreatic juice to the small intestine, pancreas helps to break down carbohydrates, proteins, and lipids.
Cancer of pancreas or pancreatic cancer is a chronic condition associated with irregular cell growth in the ducts (an exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue which accounts for over 75 - 90% of all cases of exocrine cancers.
*Stomach cancer
Stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.
Stomach cancer is a condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
* Bowel cancer
Human Bowl is divided into 2 parts, the small bowel, is associated with the digestion and absorption of food. large bowel including the colon and rectum that involve absorption of water from the small bowel contents and break down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Bowel cancer is a condition caused by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix.
Bowel cancer is relatively very common and slowly growing and progressing in a predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including the US and Canada.
Besides some of the symptoms associated with specific types of cancer, most gastrointestinal cancers shared the general symptoms of unintended weight loss, loss of appetite, fatigue, nausea, and vomiting.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the treatment of cancer in the digestive system, researchers examined the relationship between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).
According to the results of data of published observational studies (21 case-control and four cohort studies), using a meta-analytic approach and random effects models, onion exerted the relative risk of 0.72 compared to 0.79 for total allium, 0.74 for garlic for the highest versus the lowest consumption.
Total allium including onion consumption showed an inverse relation apparently stronger in case-control studies.
These results suggested that onion has a moderate inverse association with the risk of squamous cell carcinoma of the UADT.
Additionally, according to the University Laboratories of Medical Research (LURM) in the examination of the effects of dietary components on cancer of the digestive system, onion contains active components that can influence the initiation and progression of cancer.
Furthermore, these chemical compounds have also been found to inhibit cell proliferation and metastasis, induce apoptosis.
More precisely, onion protected the integrity and viability of the cells in the digestive system through it's antioxidant, cytotoxic, and pro-apoptotic properties.
Taken altogether, onion may be considered a remedy for the prevention and treatment of cancer of the digestive system, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of dietary components on cancer of the digestive system by Zanini S1, Marzotto M, Giovinazzo F, Bassi C, Bellavite P. (PubMed)
(2) Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies by Guercio V1, Turati F2, La Vecchia C1, Galeone C2, Tavani A. (PubMed)
Phytochemical Betacyanins Protects the Liver Against Injury in Vivo
The liver is the largest internal organ not only plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body but also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Liver disease is a class of medical condition characterized by reducing partly or completely the function of the liver, including liver injury.
Most common symptoms of liver injury are totally depending on the severity of the injury that affects the liver function. In serious cases of liver injury, symptoms may include jaundice, pain in your upper right abdomen, abdominal swelling, gastrointestinal symptoms such as nausea and vomiting, disorientation or confusion and sleepiness.
Most common causes of liver injury include
* Overdose of certain medication, especially acetaminophen overdose. Believer, it or not, taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the US.
* Overdose of some prescription medications, including antibiotics, nonsteroidal anti-inflammatory drugs, and anticonvulsants is also associated with liver injury.
* Overdose of herbal extracts such as green tea ECG
* Toxins
Exposure to toxic chemicals such as refrigerants and solvents for waxes and eating toxic food such as wild mushroom may cause liver injury.
Out of many risk factors involved in liver injury, some researchers suggested alcohol intoxication, a condition of alcohol poisoning caused by excessively high levels of the recent drinking of ethanol in the blood (alcohol) may be one of the major culprits that cause the long-term injury to the liver.
Over time, excessive alcohol drinking can lead to fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis.
The Canadian Liver Association wrote, "When the liver has too much alcohol to handle, normal liver function may be interrupted leading to a chemical imbalance. If the liver is required to detoxify alcohol continuously, liver cells may be destroyed or altered resulting in fat deposits (fatty liver), and more seriously, either inflammation (alcoholic hepatitis), and/or permanent scarring (cirrhosis).
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the prevention of liver injury, researchers examined the protective effect of betanin, a chemical compound found in the class of betacyanins on the liver.
In fish pretreated with 1, 2, and 4 % betanin in fodder throughout the experiment for 20 days before intraperitoneally injected with 20 % (v/v in peanut oil) CCl4 at a volume of 0.5 mL/kg body weight, researchers showed that* Injection of CCl4 induced liver injury by promoting the expression of liver CYP2E1 which has been found to increased in patient with liver disease, and oxidative stress.
* Elevated serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) activities and liver histological damage in CCl4 fish were also decreased in the treatment group.
More precisely, compared with the CCl4 control group, the betanin-treated groups exhibited reduced CYP2E1 activity, decreased malondialdehyde level, increased liver antioxidative capacity (increased glutathione level and superoxide dismutase and catalase activities).
In other words, all parameters associated with liver injury in the CCl4 group are inhibited by the administration of betanin.
Based on the finding, researchers said, " In conclusion, betanin attenuates CCl4-induced liver damage in common carp. Moreover, the inhibition of CYP2E1 activity and oxidative stress may have significant roles in the protective effect of betanin".
Taken altogether, betacyanins processed abundantly bioactive compound betanin may be considered a remedy for the prevention and treatment of liver injury, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.) by Han J1, Gao C, Yang S, Wang J, Tan D. (PubMed)
(2) Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury by Galati EM1, Mondello MR, Lauriano ER, Taviano MF, Galluzzo M, Miceli N.(PubMed)
(3) Alcohol-Related Complications by the Canadian Liver Association
Liver disease is a class of medical condition characterized by reducing partly or completely the function of the liver, including liver injury.
Most common symptoms of liver injury are totally depending on the severity of the injury that affects the liver function. In serious cases of liver injury, symptoms may include jaundice, pain in your upper right abdomen, abdominal swelling, gastrointestinal symptoms such as nausea and vomiting, disorientation or confusion and sleepiness.
Most common causes of liver injury include
* Overdose of certain medication, especially acetaminophen overdose. Believer, it or not, taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the US.
* Overdose of some prescription medications, including antibiotics, nonsteroidal anti-inflammatory drugs, and anticonvulsants is also associated with liver injury.
* Overdose of herbal extracts such as green tea ECG
* Toxins
Exposure to toxic chemicals such as refrigerants and solvents for waxes and eating toxic food such as wild mushroom may cause liver injury.
Out of many risk factors involved in liver injury, some researchers suggested alcohol intoxication, a condition of alcohol poisoning caused by excessively high levels of the recent drinking of ethanol in the blood (alcohol) may be one of the major culprits that cause the long-term injury to the liver.
Over time, excessive alcohol drinking can lead to fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis.
The Canadian Liver Association wrote, "When the liver has too much alcohol to handle, normal liver function may be interrupted leading to a chemical imbalance. If the liver is required to detoxify alcohol continuously, liver cells may be destroyed or altered resulting in fat deposits (fatty liver), and more seriously, either inflammation (alcoholic hepatitis), and/or permanent scarring (cirrhosis).
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the prevention of liver injury, researchers examined the protective effect of betanin, a chemical compound found in the class of betacyanins on the liver.
In fish pretreated with 1, 2, and 4 % betanin in fodder throughout the experiment for 20 days before intraperitoneally injected with 20 % (v/v in peanut oil) CCl4 at a volume of 0.5 mL/kg body weight, researchers showed that* Injection of CCl4 induced liver injury by promoting the expression of liver CYP2E1 which has been found to increased in patient with liver disease, and oxidative stress.
* Elevated serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) activities and liver histological damage in CCl4 fish were also decreased in the treatment group.
More precisely, compared with the CCl4 control group, the betanin-treated groups exhibited reduced CYP2E1 activity, decreased malondialdehyde level, increased liver antioxidative capacity (increased glutathione level and superoxide dismutase and catalase activities).
In other words, all parameters associated with liver injury in the CCl4 group are inhibited by the administration of betanin.
Based on the finding, researchers said, " In conclusion, betanin attenuates CCl4-induced liver damage in common carp. Moreover, the inhibition of CYP2E1 activity and oxidative stress may have significant roles in the protective effect of betanin".
Taken altogether, betacyanins processed abundantly bioactive compound betanin may be considered a remedy for the prevention and treatment of liver injury, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.) by Han J1, Gao C, Yang S, Wang J, Tan D. (PubMed)
(2) Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury by Galati EM1, Mondello MR, Lauriano ER, Taviano MF, Galluzzo M, Miceli N.(PubMed)
(3) Alcohol-Related Complications by the Canadian Liver Association
Friday, August 30, 2019
Phytochemical Alliin Promotes Balanced Ratio of Gut Microbiota
Inflammation is a natural response of the immune system with an aim to protect our body against the foreign micro pathogens which may infect the body tissue.
In the early phase of infection, after receiving the message from the central nervous system, the white blood cells of the immune first-line defense macrophages stimulate the production of blood palette to the cover the site of tissue damage and injury and inflammatory cytokines to destroy the microorganisms which try to enter the body through the wound.
Depending on the size of the injury, most small tissues damage are healed by itself within a day or weeks. In some cases, stitches may be needed.
However, if the immune system can not drive out all the invader in a period of 3-8 weeks, it will compromise, leading to low-grade inflammation.
Over time, long-term low-grade inflammation may cause tissue damage and alternation of cell DNA, leading to chronic diseases such as cardiovascular disease, diabetes, and cancer.
Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.
Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.
In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the protection of gut microbiota, researchers examined the effect of alliin (S-allyl-L-cysteine sulfoxide (ACSO)) on plasma ethanol concentration due to alcohol intake by accelerating ethanol metabolism and preventing ethanol absorption from the gut in rats.
Injection of high ACSO content (Garlic-H) suppressed elevation in concentrations of ethanol and acetaldehyde in plasma in the experimental rats without affecting much of the plasma acetate.
Furthermore, the inhibition of alcohol ethanol was attributed to the activity of alliin in the promotion of the activities of alcohol dehydrogenase and aldehyde dehydrogenase, a group of enzymes that catalyze the oxidation of aldehydes.
Compared to the absorption of ethanol from the stomach and jejunum, alliin ACSO and Garlic-H suppressed the absorption of ethanol from the stomach and jejunum, but the suppression in the jejunum was less than in the stomach.
In other words, alliin protects the gut microbiota by inhibiting ethanol absorption and accelerating ethanol metabolism.
In dextran sulfate sodium (DSS)-induced colitis mice and lipopolysaccharide-stimulated RAW264.7 cell model, oral administration of alliin at 500 mg/kg significantly inhibited the decrease of body weight, improved the DAI and decreased the infiltration of inflammatory cells in colonic tissues.
The levels of pro-inflammatory expressions and pro-inflammation activation proteins in the gut and content of NO, MDA, and MPO of gut stress markers were also inhibited by the injection alliin.
Based on the findings, researchers wrote, "Our results show that alliin ameliorates DSS-induced ulcerative colitis and inhibits the inflammatory responses in LPS-stimulated RAW264.7 cells partly".
Taken altogether, alliin may be considered supplements for the prevention and treatment of gut microbiota imbalanced as seen in colitis patients, pending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) S-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from gut by Uto-Kondo H1, Hase A2, Yamaguchi Y2, Sakurai A2, Akao M2, Saito T3, Kumagai H. (PubMed)
(2) Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation by Shi L1, Lin Q1, Li X2, Nie Y1, Sun S1, Deng X3, Wang L1, Lu J1, Tang Y1, Luo F. (PubMed)
In the early phase of infection, after receiving the message from the central nervous system, the white blood cells of the immune first-line defense macrophages stimulate the production of blood palette to the cover the site of tissue damage and injury and inflammatory cytokines to destroy the microorganisms which try to enter the body through the wound.
Depending on the size of the injury, most small tissues damage are healed by itself within a day or weeks. In some cases, stitches may be needed.
However, if the immune system can not drive out all the invader in a period of 3-8 weeks, it will compromise, leading to low-grade inflammation.
Over time, long-term low-grade inflammation may cause tissue damage and alternation of cell DNA, leading to chronic diseases such as cardiovascular disease, diabetes, and cancer.
Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.
Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.
In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the protection of gut microbiota, researchers examined the effect of alliin (S-allyl-L-cysteine sulfoxide (ACSO)) on plasma ethanol concentration due to alcohol intake by accelerating ethanol metabolism and preventing ethanol absorption from the gut in rats.
Injection of high ACSO content (Garlic-H) suppressed elevation in concentrations of ethanol and acetaldehyde in plasma in the experimental rats without affecting much of the plasma acetate.
Furthermore, the inhibition of alcohol ethanol was attributed to the activity of alliin in the promotion of the activities of alcohol dehydrogenase and aldehyde dehydrogenase, a group of enzymes that catalyze the oxidation of aldehydes.
Compared to the absorption of ethanol from the stomach and jejunum, alliin ACSO and Garlic-H suppressed the absorption of ethanol from the stomach and jejunum, but the suppression in the jejunum was less than in the stomach.
In other words, alliin protects the gut microbiota by inhibiting ethanol absorption and accelerating ethanol metabolism.
In dextran sulfate sodium (DSS)-induced colitis mice and lipopolysaccharide-stimulated RAW264.7 cell model, oral administration of alliin at 500 mg/kg significantly inhibited the decrease of body weight, improved the DAI and decreased the infiltration of inflammatory cells in colonic tissues.
The levels of pro-inflammatory expressions and pro-inflammation activation proteins in the gut and content of NO, MDA, and MPO of gut stress markers were also inhibited by the injection alliin.
Based on the findings, researchers wrote, "Our results show that alliin ameliorates DSS-induced ulcerative colitis and inhibits the inflammatory responses in LPS-stimulated RAW264.7 cells partly".
Taken altogether, alliin may be considered supplements for the prevention and treatment of gut microbiota imbalanced as seen in colitis patients, pending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) S-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from gut by Uto-Kondo H1, Hase A2, Yamaguchi Y2, Sakurai A2, Akao M2, Saito T3, Kumagai H. (PubMed)
(2) Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation by Shi L1, Lin Q1, Li X2, Nie Y1, Sun S1, Deng X3, Wang L1, Lu J1, Tang Y1, Luo F. (PubMed)
Green Tea in Alleviated Symptoms and Treatment of Chronic Back Pain
Green tea may have a therapeutic and positive effect in ameliorated symptoms and treatment of chronic back pain, some scientists suggested.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Back pain is a condition of musculoskeletal disorders(MSDs) of the spine caused by various factors, including bone fractures, muscle or ligament injury, arthritis, herniated discs. aging,..
Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through facilitating anti-inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in the induction of back pain.
According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributed to the inflammatory pain hypersensitivity in the site of infection observed by the reverse transcription-polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.
Furthermore, the application also displayed a strong effect in reduced expression of
p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.
Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.
Moreover, in the radiculopathy pain component, researchers also indicated that EGCG inhibited the inflammation in the precipitated back pain through modulation of the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in responded to stress stimuli in mediated production of pain-related pro-inflammatory cytokines such as IL-1β.
Some researchers postulated that back pain may also be induced by muscle degeneration and impairment nerve injury, leading to increased levels of reactive oxygen species in induced tissue apoptosis.
In crushing of the sciatic nerve induced back pain in a tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gain in the percentage motor deficit.
More importantly, EGCG expressed a significant effect on the recovery of sensory innervation in neuropathic pain-like syndrome and improvement of muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.
According to the RT-PCR assay, EGCG treatment also normalizing the Bax/Bcl-2 ratio, the abnormal ratio of the Bax/Bcl-2 ratio has been found to associate in the induction of nerve cell apoptosis as well as inhibited levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.
These results demonstrated an important effect of green tea EGCG in enhanced functional recovery, protected muscle fibers from cellular death, and improved morphological recovery in skeletal muscle after nerve injuries.
However, in the study of caffeine activity in the modulation of pain perception in chronic pain states of 131 patients with chronic low back pain (64 men and 67 women; mean age = 42.1 years; mean duration of pain = 6.1 years) referred to a multidisciplinary pain clinic over a 2-year period, researchers found that in compared to caffeine intake regardless concentration, caffeine is not related to the global experience of pain and disability in patients with chronic low back pain, although high caffeine use may be embedded in a context of other unhealthy lifestyle behaviors.
Taken together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered as a functional food in reduced back pain caused by physical damage of the spine and injured nerve cells. Intake of green tea supplement should be taken exceptional care as some cases of liver acute toxicity have been reported in the medical literature.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST.(PubMed)
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Back pain is a condition of musculoskeletal disorders(MSDs) of the spine caused by various factors, including bone fractures, muscle or ligament injury, arthritis, herniated discs. aging,..
Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through facilitating anti-inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in the induction of back pain.
According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributed to the inflammatory pain hypersensitivity in the site of infection observed by the reverse transcription-polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.
Furthermore, the application also displayed a strong effect in reduced expression of
p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.
Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.
Moreover, in the radiculopathy pain component, researchers also indicated that EGCG inhibited the inflammation in the precipitated back pain through modulation of the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in responded to stress stimuli in mediated production of pain-related pro-inflammatory cytokines such as IL-1β.
Some researchers postulated that back pain may also be induced by muscle degeneration and impairment nerve injury, leading to increased levels of reactive oxygen species in induced tissue apoptosis.
In crushing of the sciatic nerve induced back pain in a tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gain in the percentage motor deficit.
More importantly, EGCG expressed a significant effect on the recovery of sensory innervation in neuropathic pain-like syndrome and improvement of muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.
According to the RT-PCR assay, EGCG treatment also normalizing the Bax/Bcl-2 ratio, the abnormal ratio of the Bax/Bcl-2 ratio has been found to associate in the induction of nerve cell apoptosis as well as inhibited levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.
These results demonstrated an important effect of green tea EGCG in enhanced functional recovery, protected muscle fibers from cellular death, and improved morphological recovery in skeletal muscle after nerve injuries.
However, in the study of caffeine activity in the modulation of pain perception in chronic pain states of 131 patients with chronic low back pain (64 men and 67 women; mean age = 42.1 years; mean duration of pain = 6.1 years) referred to a multidisciplinary pain clinic over a 2-year period, researchers found that in compared to caffeine intake regardless concentration, caffeine is not related to the global experience of pain and disability in patients with chronic low back pain, although high caffeine use may be embedded in a context of other unhealthy lifestyle behaviors.
Taken together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered as a functional food in reduced back pain caused by physical damage of the spine and injured nerve cells. Intake of green tea supplement should be taken exceptional care as some cases of liver acute toxicity have been reported in the medical literature.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST.(PubMed)
Thursday, August 29, 2019
Phytochemical indicaxanthin, the Best Natural Promotion of Myeloperoxidase Function Against Microbial Infection
Myeloperoxidase (MPO) is a peroxidase enzyme found most abundantly in white blood cells neutrophil granulocytes.
Myeloperoxidase (MPO) processes a critical role that protects our body against the invasion of microorganisms.
In cellular levels, myeloperoxidase (MPO) demonstrated to be a local mediator of tissue damage by stimulating the production of proinflammatory cytokines with an aim to protect the cell against the invasion of pathogens which may enter the body to induce the acute phase of infection.
In other words, MPO deficiency that induces the exaggerates of the inflammatory response and affects neutrophil functions including cytokine production has been found to reduce the immune function in the acute phase of infection that leads to chronic low-grade inflammatory disease.
MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.
However, genetic preposition may be the primary condition that causes the onset of PMO deficiency.
Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degree of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in primary form. Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".
And, " Most of the mutations associated with the hereditary form are R569W (the commonest), Y173C, M251T, G501S, and R499C and a deletion of 14 bases (D14) within exon 9. It is noteworthy that eosinophils are never involved in MPO deficiency since eosinophil peroxidase is encoded by another gene than MPO".
Isobetanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...
With an aim to find a potent compound for the prevention and treatment of bacterial infection, researchers examiend the effects of phytochemical indicaxanthin on enzyme myeloperoxidase.
The kinetic study conducted by the University of Palermo was to examine the interaction between the betalains, betanin, and indicaxanthin as redox intermediates of compound I and compound II of MPO.
Based on the tested differentiation, both compound I and compound II exhibited significant antioxidant activity was found to associate with the concentration of betanin and indicaxanthin.
The presence of betalains and indicaxanthin exhibited the function of MPO in scavenging hypochlorous acid at pH 7.0 and 25 degrees C.
At neutral pH and depending on their concentration, both betalains and indicaxanthin.can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO.
However, at pH 5.0 both betalains and can only exhibit a stimulating and inhibitory effect on the chlorination activity of MPO in the micromolar concentrations.
Taken altogether, indicaxanthin may be considered a remedy for the promotion of the antibacterial activity of myeloperoxidase, pending to the confirmation of the larger sample size and multicenter human study.
Intake of isobetanin and betalains in the form of supplement should be taken with extreme care to prevent liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) "Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid" by Allegra M, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C.(PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(3) Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function by Aratani Y. (PubMed)
Myeloperoxidase (MPO) processes a critical role that protects our body against the invasion of microorganisms.
In cellular levels, myeloperoxidase (MPO) demonstrated to be a local mediator of tissue damage by stimulating the production of proinflammatory cytokines with an aim to protect the cell against the invasion of pathogens which may enter the body to induce the acute phase of infection.
In other words, MPO deficiency that induces the exaggerates of the inflammatory response and affects neutrophil functions including cytokine production has been found to reduce the immune function in the acute phase of infection that leads to chronic low-grade inflammatory disease.
MPO deficiency has been found in patients with diabetes mellitus, pregnancy, iron deficiency, renal transplantation, thrombotic diseases, lead poisoning, obstructive jaundice, disseminated cancers, hematologic disorders, and neoplasms.
However, genetic preposition may be the primary condition that causes the onset of PMO deficiency.
Dr. Roma Pahwa wrote, "Primary MPO deficiency is inherited as an autosomal recessive disorder and is generally present with varying degree of severity and clinical features. A number of point germline mutations resulting in MPO deficiency have been detected in primary form. Some of these mutations are associated with the defective posttranslational processing of the MPO precursor protein and others with pre-translational defects caused by mutations in the regulatory portion of the MPO gene".
And, " Most of the mutations associated with the hereditary form are R569W (the commonest), Y173C, M251T, G501S, and R499C and a deletion of 14 bases (D14) within exon 9. It is noteworthy that eosinophils are never involved in MPO deficiency since eosinophil peroxidase is encoded by another gene than MPO".
Isobetanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard,...
With an aim to find a potent compound for the prevention and treatment of bacterial infection, researchers examiend the effects of phytochemical indicaxanthin on enzyme myeloperoxidase.
The kinetic study conducted by the University of Palermo was to examine the interaction between the betalains, betanin, and indicaxanthin as redox intermediates of compound I and compound II of MPO.
Based on the tested differentiation, both compound I and compound II exhibited significant antioxidant activity was found to associate with the concentration of betanin and indicaxanthin.
The presence of betalains and indicaxanthin exhibited the function of MPO in scavenging hypochlorous acid at pH 7.0 and 25 degrees C.
At neutral pH and depending on their concentration, both betalains and indicaxanthin.can exhibit a stimulating and inhibitory effect on the chlorination activity of MPO.
However, at pH 5.0 both betalains and can only exhibit a stimulating and inhibitory effect on the chlorination activity of MPO in the micromolar concentrations.
Taken altogether, indicaxanthin may be considered a remedy for the promotion of the antibacterial activity of myeloperoxidase, pending to the confirmation of the larger sample size and multicenter human study.
Intake of isobetanin and betalains in the form of supplement should be taken with extreme care to prevent liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) "Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid" by Allegra M, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C.(PubMed)
(2) Myeloperoxidase Deficiency by Roma Pahwa; Ishwarlal Jialal. (NCBI)
(3) Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function by Aratani Y. (PubMed)
Green Tea and its Bioactive Polyphenols in Attenuated Early Onset, Progression and Treatment of Osteoporosis
Green tea may have a therapeutic and positive effect in reduced onset. progression and treatment of osteoporosis, some scientists suggested.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Osteoporosis is a chronic condition characterized by progression in reduced bone mass and deterioration of bone tissue and considered as a major health problem in both elderly men and women.
In the study to evaluate the effects of ingestion of green tea and green tea bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that application of green tea and its bioactive compounds exert significant activities in reduced onset of osteoporosis, through its antioxidants and its initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibited the levels of ROS in facilitated the chain reaction.
Truly, the overexpression of free radicals has been associated with the change in the balance between activities of osteoblasts and osteoclasts, leading to osteoclasts in destroyed the calcified tissue and induced bone remodeling.
These results demonstrated a significant decrease of risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.
Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that ingestion of green and its bioactive compound display an impressive osteo-protective impact on bone mass and microarchitecture in various bone loss models associated to aging, sex hormone deficiency, and chronic inflammation.
The implication of reduced onset and progression of osteoporosis in aging population due to sex hormone deficiency of the study may be attributed to green tea and its bioactive compound in increased the levels of osteocalcin, a bone formation marker, decreased serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improved the body in absorption of calcium.
In fact, the serum of serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) is considered as an effective measurement in the rate of bone turn over in patients with osteoporosis.
Interestingly, application of green tea and its bioactive compound also found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, through inhibited the production of C-reactive protein (CRP) production in the liver in demonstrated of inflammation by reduced levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.
These differentiation were supported by the study in evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.
At the end of experiment, researchers found that rats treated with GTP demonstrate an increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; increased trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft; decreased eroded surface in the proximal tibia and endocortical tibial shaft; and increased liver glutathione peroxidase activity.
These results indicated a strong implication of green tea polyphenols in decreased cortical and trabecular bone loss and increased both bone density by stimulated overexpression of bone formation and reduced bone resorption via antioxidant capacity.
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated early-onset, progression and combined with standard medicine for the treatment of osteoporosis. However, the intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS.(PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS.(PubMed)
(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK.(PubMed)
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Osteoporosis is a chronic condition characterized by progression in reduced bone mass and deterioration of bone tissue and considered as a major health problem in both elderly men and women.
In the study to evaluate the effects of ingestion of green tea and green tea bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that application of green tea and its bioactive compounds exert significant activities in reduced onset of osteoporosis, through its antioxidants and its initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibited the levels of ROS in facilitated the chain reaction.
Truly, the overexpression of free radicals has been associated with the change in the balance between activities of osteoblasts and osteoclasts, leading to osteoclasts in destroyed the calcified tissue and induced bone remodeling.
These results demonstrated a significant decrease of risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.
Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that ingestion of green and its bioactive compound display an impressive osteo-protective impact on bone mass and microarchitecture in various bone loss models associated to aging, sex hormone deficiency, and chronic inflammation.
The implication of reduced onset and progression of osteoporosis in aging population due to sex hormone deficiency of the study may be attributed to green tea and its bioactive compound in increased the levels of osteocalcin, a bone formation marker, decreased serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improved the body in absorption of calcium.
In fact, the serum of serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) is considered as an effective measurement in the rate of bone turn over in patients with osteoporosis.
Interestingly, application of green tea and its bioactive compound also found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, through inhibited the production of C-reactive protein (CRP) production in the liver in demonstrated of inflammation by reduced levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.
These differentiation were supported by the study in evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.
At the end of experiment, researchers found that rats treated with GTP demonstrate an increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; increased trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft; decreased eroded surface in the proximal tibia and endocortical tibial shaft; and increased liver glutathione peroxidase activity.
These results indicated a strong implication of green tea polyphenols in decreased cortical and trabecular bone loss and increased both bone density by stimulated overexpression of bone formation and reduced bone resorption via antioxidant capacity.
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated early-onset, progression and combined with standard medicine for the treatment of osteoporosis. However, the intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS.(PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS.(PubMed)
(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK.(PubMed)
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