Cancer is a group of a medical and chronic condition characterized by irregular cells growth in the tissue of the specific organ in the body.
Most cases of cancer start in the cell on the surface of the inner lining tissue of an organ. After penetrating into deeper layers and colonizing the entire organ, the cancerous cells can spread to healthy tissue of other organs through lymph and blood.
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.
Bladder cancer occurs when cells mass in the inner lining of the bladder forms a malignant growth or tumor. Bladder cancer developed in the bladder lining has also been found to spread through the bladder wall to nearby organs such as the prostate gland in men or the uterus in women.
Bladder cancer can be classified depending on its proliferation
* Superficial types of bladder cancer
The most recurrent type of bladder cancers has a characteristic by noninvasive. These types of bladder cancer can be controlled or removed by regular cystoscopy.
* Invasive types of bladder cancer
Invasive types of bladder cancer tend to spread after beginning in cells in the lining of the bladder. These types of cancer often require surgery by removing part or the whole bladder.
The exact causes of bladder cancer are not identified. However, smoking has been found to induce a substantial risk of bladder cancer incidence.
Dr. Neal D Freedman, the lead scientist wrote, "...the population attributable risk of bladder cancer for tobacco smoking is 50–65% in men and 20–30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking".
And, "Compared to a pooled estimate of US data from cohorts initiated between 1963 and 1987, relative risks for smoking in the more recent NIH-AARP cohort were higher, with population attributable risks for women compared to those for men".
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural pigment for the prevention and treatment of cancer, researchers examined Betacyanins (BC) purified from beetroot (Beta vulgaris var. Rubra L.) tested, alone or in combination with vitexin-2-O-xyloside (XVX) from Beta vulgaris var. cicla L. in the proliferation rate in T24 bladder cancer cells.
According to the tested analysis,* Combination of BC and XVX exhibited a synergistic effect that inhibits proliferation in T24 cancer cells at 24 and 48 h but not after 72 h of incubation.
* The combination induced apoptosis of T24 bladder cancer cells observed by means of fluorescence-activated cell sorting (FACS) analysis by increasing the expression in caspases associated with cell death programming.
The inhibition of bladder cancer cell line was found to enhance the expression levels of the pro-apoptotic gene and inhibit anti-apoptotic and survival proteins.
Extrinsically, administration of BC increase of the activity of caspase 8, a protein associated with the induction of apoptosis.
Interestingly, the XVX, BC, and their combination induced cancer cell death without exhibiting a cytotoxic effect on normal and healthy human cells.
Based on the findings, Dr. Scarpa ES, the lead scientist said, "the efficacy and the mechanisms of the action of BC and XVX, extracted from edible plants, and suggested that a diet or a nutrition supplement, enriched with these bioactive molecules, could be used in the prevention of human bladder cancer".
Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of bladder cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
(2) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Scarpa ES1, Emanuelli M2, Frati A1, Pozzi V2, Antonini E1, Diamantini G1, Di Ruscio G3, Sartini D3, Armeni T3, Palma F1, Ninfali P. (PubMed)
(3) Bladder Cancer by Kyle J, Norton
(4) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)
Monday, September 2, 2019
Green Tea and its Bioactive Polyphenols Epigallocatechin-3-gallate in Attenuated Risk and Treatment of Autoimmune Hepatitis
Green tea may have a therapeutic and positive effect in reduced risk and treatment of autoimmune hepatitis, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Autoimmune hepatitis is a medical condition characterized by the immune system attacking the liver cells in the induction of liver cirrhosis as a result of long term liver cellular inflammation and necrosis.
The study of concanavalin A (ConA) (25 mg/kg) induced autoimmune hepatitis in mice, pretreatment of green tea exerted a strong inhibition of inflammatory cytokines through increased Bcl-2 expression with function of blocking the apoptotic death of some cells and deceased activity of protein Bax in activating p53 a tumor suppressor to induce cell death and caspase-3, and Caspase-9 proteins in signaling molecules in responsible for executing cell death in compared to ConA-treated group within 8 hours of applications, according to observation of TUNEL assay by detecting apoptotic cells that undergo extensive DNA degradation.
In other words, green tea EGCG administration reduced the expression of ConA in the induction of decreased numbers of infectious cells being attacked by the immune system, thus ameliorated the risk of liver cell damage.
Further differentiation indicated that application of green tea bioactive polyphenols Epigallocatechin-3-gallate (10 or 30 mg/kg) orally twice daily for 10 days before ConA injection demonstrates a significant activity in reduced activation of BNIP3, a member of the apoptotic Bcl-2 protein family in mediated infectious cell apoptosis through autophagy in induced destruction of damaged or redundant cellular components in compared to lectin ConA.
The result of green tea EGCG efficacy in induction of BNIP3 to decrease expression of concanavalin A (ConA) in reduction of numbers infectious cell proliferation was attributed to the IL-6/JAK/STAT3 signaling pathway which plays an important role in the mechanisms in exhibited green tea EGCG antioxidant activity in blocking infectious cells migration and invasion in exhibited hepatoprotective effect.
In other words, said, Dr. Li S, the lead scientist "EGCG attenuated liver injury in ConA-induced hepatitis by down-regulating IL-6/JAKs/STAT3/BNIP3-mediated apoptosis and autophagy".
Further differentiation also found that green tea EGCG administration inhibited the immune overreaction and pathological damage by decreased expression of inflammatory cytokines induced by Tumor necrosis factor (TNF), tumor necrosis factor-alpha, a cell-signaling protein (cytokine) in the activated systemic inflammation in the acute phase infection.
Additionally, green tea also modulated the inflammatory factors, interleukin 6 (IL-6), the pro-inflammatory cytokines and anti-inflammatory cytokines promptly and transiently produced in response to infections and tissue injuries and interferon-gamma (IFN-γ), a cytokine that plays an important role in inducing and modulating immune responses to the infectious tissue, as well as cytokine interleukin-1β (IL-1β), a key mediator of the inflammatory response in protected body against pathological invasion.
Taken together, green tea and its bioactive Epigallocatechin-3-gallate EGCG may be considered a functional food to reduced risk and used a combination with standard therapy for the treatment of autoimmune hepatitis.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3. by Li S1, Xia Y1, Chen K1, Li J1, Liu T1, Wang F1, Lu J1, Zhou Y1, Guo C1.(PMC)
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Autoimmune hepatitis is a medical condition characterized by the immune system attacking the liver cells in the induction of liver cirrhosis as a result of long term liver cellular inflammation and necrosis.
The study of concanavalin A (ConA) (25 mg/kg) induced autoimmune hepatitis in mice, pretreatment of green tea exerted a strong inhibition of inflammatory cytokines through increased Bcl-2 expression with function of blocking the apoptotic death of some cells and deceased activity of protein Bax in activating p53 a tumor suppressor to induce cell death and caspase-3, and Caspase-9 proteins in signaling molecules in responsible for executing cell death in compared to ConA-treated group within 8 hours of applications, according to observation of TUNEL assay by detecting apoptotic cells that undergo extensive DNA degradation.
In other words, green tea EGCG administration reduced the expression of ConA in the induction of decreased numbers of infectious cells being attacked by the immune system, thus ameliorated the risk of liver cell damage.
Further differentiation indicated that application of green tea bioactive polyphenols Epigallocatechin-3-gallate (10 or 30 mg/kg) orally twice daily for 10 days before ConA injection demonstrates a significant activity in reduced activation of BNIP3, a member of the apoptotic Bcl-2 protein family in mediated infectious cell apoptosis through autophagy in induced destruction of damaged or redundant cellular components in compared to lectin ConA.
The result of green tea EGCG efficacy in induction of BNIP3 to decrease expression of concanavalin A (ConA) in reduction of numbers infectious cell proliferation was attributed to the IL-6/JAK/STAT3 signaling pathway which plays an important role in the mechanisms in exhibited green tea EGCG antioxidant activity in blocking infectious cells migration and invasion in exhibited hepatoprotective effect.
In other words, said, Dr. Li S, the lead scientist "EGCG attenuated liver injury in ConA-induced hepatitis by down-regulating IL-6/JAKs/STAT3/BNIP3-mediated apoptosis and autophagy".
Further differentiation also found that green tea EGCG administration inhibited the immune overreaction and pathological damage by decreased expression of inflammatory cytokines induced by Tumor necrosis factor (TNF), tumor necrosis factor-alpha, a cell-signaling protein (cytokine) in the activated systemic inflammation in the acute phase infection.
Additionally, green tea also modulated the inflammatory factors, interleukin 6 (IL-6), the pro-inflammatory cytokines and anti-inflammatory cytokines promptly and transiently produced in response to infections and tissue injuries and interferon-gamma (IFN-γ), a cytokine that plays an important role in inducing and modulating immune responses to the infectious tissue, as well as cytokine interleukin-1β (IL-1β), a key mediator of the inflammatory response in protected body against pathological invasion.
Taken together, green tea and its bioactive Epigallocatechin-3-gallate EGCG may be considered a functional food to reduced risk and used a combination with standard therapy for the treatment of autoimmune hepatitis.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3. by Li S1, Xia Y1, Chen K1, Li J1, Liu T1, Wang F1, Lu J1, Zhou Y1, Guo C1.(PMC)
Sunday, September 1, 2019
Green Tea in Ameliorated Symptoms, Progression and Treatment of Tendinitis
Green tea may have a therapeutic and positive effect in reduced symptoms, progression and treatment of tendinitis, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Tendinitis is a condition characterized by inflammation of a tendon as a result of overuse, infection or rheumatic disease.
According to the study of the effect of GT and/or glycine in the diet on tendinitis on Wistar rats, randomly divided into seven groups (G): control group (C); G1 and G4, tendinitis; G2 and G5, tendinitis supplied with GT; and G3 and G6, tendinitis supplied with GT and a glycine diet for 7 or 21 days, respectively, group with tendinitis treated with green tea demonstrated a significant effect in enhanced collagen stability through expression of hydroxyproline in compared to other groups.
Furthermore, GT and glycine alone treated groups showed an increased activity of metalloproteinase-2 MMP-2 levels which has been associated to the healing process of the fibrous connective tissue in tendinitis patients.
In compared to control and non GT treatment groups, application of green tea or GT+ glycine group displayed a statistical significance in the decreased muscle retardation.
After taking into account of other co-founders, Dr. Vieira CP, the lead author said, " GT + a glycine diet has beneficial effects that aid in the recovery process of the tendon after tendinitis".
Interestingly, in the study investigated the remodeling effects of green tea and glycine in the myotendinous junction (MTJ) of male Wistar rats with tendinitis, randomly divided into five groups: animals without tendinitis and animals with tendinitis; animals with tendinitis supplied with green tea; animals with tendinitis supplied with a glycine diet; animals with tendinitis supplied with a green tea and glycine diet, researcher found that all treatment groups exerted a profound effect in regulated the activity of metalloproteinases (MMP)-2 with function in remodeling the tendon after tendinitis, MMP-8 and -9 which are associated to remodeling tissue expression in the disease progression and induced the synthesis of type I collagen regulation by cell spreading, platelet-derived growth factor and interactions with collagen fibers.
Moreover, rats groups treated above application also demonstrated an increase of glycosaminoglycans, in stimulated the regenerative processes, while maintaining host cell characteristics and function and non-collagenous proteins in modulated the development of fine fibrils presented in collagen fibers of connective tissue
Additionally, the combination of green tea and glycine also modulated the inflammatory process through stimulated production of anti-inflammatory factors and induced the synthesis of the elements, such as extracellular matrix involved in the post-lesion recovery of the tissue.
These results indicated an important recovery from injured tendon through improving the compaction of the collagen molecules and inducing the assembly of early collagen fibers, in green tea and glycin treated groups.
After considering of all cofounders, researchers and colleagues at the Anat Rec said, " each region of the inflamed tendon can exhibit different responses during the treatment and therefore, modify its extracellular matrix components to facilitate recovery and repair".
The information findings suggested that green tea may be considered as a functional food for reduced symptoms, progression and used with glycin and conventional standard medicine for the treatment of
tendinitis. However, intake of supplement for treatment of tendinitis should be taken with exceptional care in prevented toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea and Glycine Modulate the Activity of Metalloproteinases and Collagen in the Tendinitis of the Myotendinous Junction of the Achilles Tendon by Vieira CP1, De Oliveira LP2, Da Ré Guerra F3, Marcondes MC2, Pimentel ER2.(PubMed)
(2) Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats by Vieira CP1, Guerra Fda R, de Oliveira LP, Almeida MS, Marcondes MC, Pimentell ER.(PubMed)
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Tendinitis is a condition characterized by inflammation of a tendon as a result of overuse, infection or rheumatic disease.
According to the study of the effect of GT and/or glycine in the diet on tendinitis on Wistar rats, randomly divided into seven groups (G): control group (C); G1 and G4, tendinitis; G2 and G5, tendinitis supplied with GT; and G3 and G6, tendinitis supplied with GT and a glycine diet for 7 or 21 days, respectively, group with tendinitis treated with green tea demonstrated a significant effect in enhanced collagen stability through expression of hydroxyproline in compared to other groups.
Furthermore, GT and glycine alone treated groups showed an increased activity of metalloproteinase-2 MMP-2 levels which has been associated to the healing process of the fibrous connective tissue in tendinitis patients.
In compared to control and non GT treatment groups, application of green tea or GT+ glycine group displayed a statistical significance in the decreased muscle retardation.
After taking into account of other co-founders, Dr. Vieira CP, the lead author said, " GT + a glycine diet has beneficial effects that aid in the recovery process of the tendon after tendinitis".
Interestingly, in the study investigated the remodeling effects of green tea and glycine in the myotendinous junction (MTJ) of male Wistar rats with tendinitis, randomly divided into five groups: animals without tendinitis and animals with tendinitis; animals with tendinitis supplied with green tea; animals with tendinitis supplied with a glycine diet; animals with tendinitis supplied with a green tea and glycine diet, researcher found that all treatment groups exerted a profound effect in regulated the activity of metalloproteinases (MMP)-2 with function in remodeling the tendon after tendinitis, MMP-8 and -9 which are associated to remodeling tissue expression in the disease progression and induced the synthesis of type I collagen regulation by cell spreading, platelet-derived growth factor and interactions with collagen fibers.
Moreover, rats groups treated above application also demonstrated an increase of glycosaminoglycans, in stimulated the regenerative processes, while maintaining host cell characteristics and function and non-collagenous proteins in modulated the development of fine fibrils presented in collagen fibers of connective tissue
Additionally, the combination of green tea and glycine also modulated the inflammatory process through stimulated production of anti-inflammatory factors and induced the synthesis of the elements, such as extracellular matrix involved in the post-lesion recovery of the tissue.
These results indicated an important recovery from injured tendon through improving the compaction of the collagen molecules and inducing the assembly of early collagen fibers, in green tea and glycin treated groups.
After considering of all cofounders, researchers and colleagues at the Anat Rec said, " each region of the inflamed tendon can exhibit different responses during the treatment and therefore, modify its extracellular matrix components to facilitate recovery and repair".
The information findings suggested that green tea may be considered as a functional food for reduced symptoms, progression and used with glycin and conventional standard medicine for the treatment of
tendinitis. However, intake of supplement for treatment of tendinitis should be taken with exceptional care in prevented toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea and Glycine Modulate the Activity of Metalloproteinases and Collagen in the Tendinitis of the Myotendinous Junction of the Achilles Tendon by Vieira CP1, De Oliveira LP2, Da Ré Guerra F3, Marcondes MC2, Pimentel ER2.(PubMed)
(2) Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats by Vieira CP1, Guerra Fda R, de Oliveira LP, Almeida MS, Marcondes MC, Pimentell ER.(PubMed)
Lycopene the Best Anti Cardiovascular Disease Phytochemical
Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle. Depending on the location of heart muscle damage or the blood vessel blockage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart.
Heart failure, a major health problem associated with the reduced function of the heart, is a leading cause of hospitalization in people older than age 65. Believe it or not, more than 6.5 million Americans are living with the condition of heart failure.
According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the US. More precisely, 1 in every 4 deaths in the US every year are caused by heart disease.
Furthermore, every year about 735,000 Americans has a heart attack including the first attack of 525,000 patients.
The exact causes of cardiovascular disease are not cleared. However, epidemiologically family history, age ethnicity, gender, medical conditions such as cholesterol high blood pressure and diabetes has been found in most patients with CVD.
Some researchers in the examined the correlation between a high-fat diet and cardiovascular disease in obese patients suggested that the promotion of a high-fat diet over the past few decades may be one major culprit that causes the onset of CVD.
Dr. Jane E Freedman wrote, " According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease.".
And, " clearly established diseases associated with high-fat or high-calorie diets can be offset by the use of nutritional supplements. Although these findings beckon us to draw broader implications, even if proven true in larger studies, it is doubtful that this will lead to a recommendation of high-calorie, high-fat diets".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
On finding a natural compound for the prevention of cardiovascular disease, researchers examined the effect of lycopene by a meta-analysis.
According to the 14 studies identified by the search in the medical literature of the database of Pubmed, Embase, and Web of Science from inception to October 2016,* Lycopene exerted a significant inverse association with a pooled risk ratio (RR) of 0.83 in the risk of CVD.
* Furthermore, dietary lycopene intake was statistically significant in the reduction of risk of coronary heart disease (CHD) with an RR of 0.87 and stroke with an RR of 0.83.
* Lycopene biomarker concentrations were also inversely associated with the risk CVD.
Based on the findings, researchers wrote in the final report, "Higher lycopene exposure is inversely associated with a lower risk of CVD".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of CVD, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Deficiency in Ageing and Cardiovascular Disease by Petyaev IM. (PubMed)
(2) Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies by Song B1, Liu K1, Gao Y1, Zhao L1, Fang H1, Li Y1, Pei L1, Xu Y. (PubMed)
(2) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (JACC Journals)
Heart failure, a major health problem associated with the reduced function of the heart, is a leading cause of hospitalization in people older than age 65. Believe it or not, more than 6.5 million Americans are living with the condition of heart failure.
According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the US. More precisely, 1 in every 4 deaths in the US every year are caused by heart disease.
Furthermore, every year about 735,000 Americans has a heart attack including the first attack of 525,000 patients.
The exact causes of cardiovascular disease are not cleared. However, epidemiologically family history, age ethnicity, gender, medical conditions such as cholesterol high blood pressure and diabetes has been found in most patients with CVD.
Some researchers in the examined the correlation between a high-fat diet and cardiovascular disease in obese patients suggested that the promotion of a high-fat diet over the past few decades may be one major culprit that causes the onset of CVD.
Dr. Jane E Freedman wrote, " According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease.".
And, " clearly established diseases associated with high-fat or high-calorie diets can be offset by the use of nutritional supplements. Although these findings beckon us to draw broader implications, even if proven true in larger studies, it is doubtful that this will lead to a recommendation of high-calorie, high-fat diets".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
On finding a natural compound for the prevention of cardiovascular disease, researchers examined the effect of lycopene by a meta-analysis.
According to the 14 studies identified by the search in the medical literature of the database of Pubmed, Embase, and Web of Science from inception to October 2016,* Lycopene exerted a significant inverse association with a pooled risk ratio (RR) of 0.83 in the risk of CVD.
* Furthermore, dietary lycopene intake was statistically significant in the reduction of risk of coronary heart disease (CHD) with an RR of 0.87 and stroke with an RR of 0.83.
* Lycopene biomarker concentrations were also inversely associated with the risk CVD.
Based on the findings, researchers wrote in the final report, "Higher lycopene exposure is inversely associated with a lower risk of CVD".
Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of CVD, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Deficiency in Ageing and Cardiovascular Disease by Petyaev IM. (PubMed)
(2) Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies by Song B1, Liu K1, Gao Y1, Zhao L1, Fang H1, Li Y1, Pei L1, Xu Y. (PubMed)
(2) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (JACC Journals)
Saturday, August 31, 2019
Healthy Food Onion Inhibits the Initiation and Progression of Gastrointestinal Tract Cancer
Digestive cancer is a group of medical conditions associated with irregular cell growth in the tissue on the gastrointestinal tract.
Most cases of gastrointestinal cancer begin in the cells on the surface of the inner lining in a specific organ, before penetrating into deeper layers to form a solid tumor through proliferation.
Most common cancers of the gastrointestinal tract are
*Esophagus
The esophagus or gullet is the tube that leads foods from the pharynx to the stomach.
Esophageal cancer is caused by abnormal cell growth in the cells that line the upper part of the esophagus or glandular cells in the lower part of the esophagus that connected with the stomach.
Esophageal cancer starts from the lining of the esophagus, then later penetrate in the wall of the esophagus and spread to the lymph node around the bottom of the esophagus, stomach and the chest.
* Gallbladder cancer
The gallbladder is a small organ under the liver with a function that aids the digestive system in fat metabolism with storing bile produced by the liver.
Gallbladder cancer arises from the cells of the tissue of the gallbladder. It is common cancer in central and South America, central and eastern Europe, Japan and northern India, but rare in North America.
*Liver cancer
The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above the stomach.
Liver cancer is a condition caused by the uncontrolled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most cases of liver cancer are diagnosed in the later stage of cancer.
According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
*Pancreas cancer pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen.
By secreting pancreatic juice to the small intestine, pancreas helps to break down carbohydrates, proteins, and lipids.
Cancer of pancreas or pancreatic cancer is a chronic condition associated with irregular cell growth in the ducts (an exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue which accounts for over 75 - 90% of all cases of exocrine cancers.
*Stomach cancer
Stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.
Stomach cancer is a condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
* Bowel cancer
Human Bowl is divided into 2 parts, the small bowel, is associated with the digestion and absorption of food. large bowel including the colon and rectum that involve absorption of water from the small bowel contents and break down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Bowel cancer is a condition caused by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix.
Bowel cancer is relatively very common and slowly growing and progressing in a predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including the US and Canada.
Besides some of the symptoms associated with specific types of cancer, most gastrointestinal cancers shared the general symptoms of unintended weight loss, loss of appetite, fatigue, nausea, and vomiting.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the treatment of cancer in the digestive system, researchers examined the relationship between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).
According to the results of data of published observational studies (21 case-control and four cohort studies), using a meta-analytic approach and random effects models, onion exerted the relative risk of 0.72 compared to 0.79 for total allium, 0.74 for garlic for the highest versus the lowest consumption.
Total allium including onion consumption showed an inverse relation apparently stronger in case-control studies.
These results suggested that onion has a moderate inverse association with the risk of squamous cell carcinoma of the UADT.
Additionally, according to the University Laboratories of Medical Research (LURM) in the examination of the effects of dietary components on cancer of the digestive system, onion contains active components that can influence the initiation and progression of cancer.
Furthermore, these chemical compounds have also been found to inhibit cell proliferation and metastasis, induce apoptosis.
More precisely, onion protected the integrity and viability of the cells in the digestive system through it's antioxidant, cytotoxic, and pro-apoptotic properties.
Taken altogether, onion may be considered a remedy for the prevention and treatment of cancer of the digestive system, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of dietary components on cancer of the digestive system by Zanini S1, Marzotto M, Giovinazzo F, Bassi C, Bellavite P. (PubMed)
(2) Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies by Guercio V1, Turati F2, La Vecchia C1, Galeone C2, Tavani A. (PubMed)
Most cases of gastrointestinal cancer begin in the cells on the surface of the inner lining in a specific organ, before penetrating into deeper layers to form a solid tumor through proliferation.
Most common cancers of the gastrointestinal tract are
*Esophagus
The esophagus or gullet is the tube that leads foods from the pharynx to the stomach.
Esophageal cancer is caused by abnormal cell growth in the cells that line the upper part of the esophagus or glandular cells in the lower part of the esophagus that connected with the stomach.
Esophageal cancer starts from the lining of the esophagus, then later penetrate in the wall of the esophagus and spread to the lymph node around the bottom of the esophagus, stomach and the chest.
* Gallbladder cancer
The gallbladder is a small organ under the liver with a function that aids the digestive system in fat metabolism with storing bile produced by the liver.
Gallbladder cancer arises from the cells of the tissue of the gallbladder. It is common cancer in central and South America, central and eastern Europe, Japan and northern India, but rare in North America.
*Liver cancer
The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above the stomach.
Liver cancer is a condition caused by the uncontrolled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most cases of liver cancer are diagnosed in the later stage of cancer.
According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
*Pancreas cancer pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen.
By secreting pancreatic juice to the small intestine, pancreas helps to break down carbohydrates, proteins, and lipids.
Cancer of pancreas or pancreatic cancer is a chronic condition associated with irregular cell growth in the ducts (an exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue which accounts for over 75 - 90% of all cases of exocrine cancers.
*Stomach cancer
Stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.
Stomach cancer is a condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
* Bowel cancer
Human Bowl is divided into 2 parts, the small bowel, is associated with the digestion and absorption of food. large bowel including the colon and rectum that involve absorption of water from the small bowel contents and break down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Bowel cancer is a condition caused by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix.
Bowel cancer is relatively very common and slowly growing and progressing in a predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including the US and Canada.
Besides some of the symptoms associated with specific types of cancer, most gastrointestinal cancers shared the general symptoms of unintended weight loss, loss of appetite, fatigue, nausea, and vomiting.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the treatment of cancer in the digestive system, researchers examined the relationship between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).
According to the results of data of published observational studies (21 case-control and four cohort studies), using a meta-analytic approach and random effects models, onion exerted the relative risk of 0.72 compared to 0.79 for total allium, 0.74 for garlic for the highest versus the lowest consumption.
Total allium including onion consumption showed an inverse relation apparently stronger in case-control studies.
These results suggested that onion has a moderate inverse association with the risk of squamous cell carcinoma of the UADT.
Additionally, according to the University Laboratories of Medical Research (LURM) in the examination of the effects of dietary components on cancer of the digestive system, onion contains active components that can influence the initiation and progression of cancer.
Furthermore, these chemical compounds have also been found to inhibit cell proliferation and metastasis, induce apoptosis.
More precisely, onion protected the integrity and viability of the cells in the digestive system through it's antioxidant, cytotoxic, and pro-apoptotic properties.
Taken altogether, onion may be considered a remedy for the prevention and treatment of cancer of the digestive system, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of dietary components on cancer of the digestive system by Zanini S1, Marzotto M, Giovinazzo F, Bassi C, Bellavite P. (PubMed)
(2) Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies by Guercio V1, Turati F2, La Vecchia C1, Galeone C2, Tavani A. (PubMed)
Phytochemical Betacyanins Protects the Liver Against Injury in Vivo
The liver is the largest internal organ not only plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body but also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Liver disease is a class of medical condition characterized by reducing partly or completely the function of the liver, including liver injury.
Most common symptoms of liver injury are totally depending on the severity of the injury that affects the liver function. In serious cases of liver injury, symptoms may include jaundice, pain in your upper right abdomen, abdominal swelling, gastrointestinal symptoms such as nausea and vomiting, disorientation or confusion and sleepiness.
Most common causes of liver injury include
* Overdose of certain medication, especially acetaminophen overdose. Believer, it or not, taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the US.
* Overdose of some prescription medications, including antibiotics, nonsteroidal anti-inflammatory drugs, and anticonvulsants is also associated with liver injury.
* Overdose of herbal extracts such as green tea ECG
* Toxins
Exposure to toxic chemicals such as refrigerants and solvents for waxes and eating toxic food such as wild mushroom may cause liver injury.
Out of many risk factors involved in liver injury, some researchers suggested alcohol intoxication, a condition of alcohol poisoning caused by excessively high levels of the recent drinking of ethanol in the blood (alcohol) may be one of the major culprits that cause the long-term injury to the liver.
Over time, excessive alcohol drinking can lead to fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis.
The Canadian Liver Association wrote, "When the liver has too much alcohol to handle, normal liver function may be interrupted leading to a chemical imbalance. If the liver is required to detoxify alcohol continuously, liver cells may be destroyed or altered resulting in fat deposits (fatty liver), and more seriously, either inflammation (alcoholic hepatitis), and/or permanent scarring (cirrhosis).
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the prevention of liver injury, researchers examined the protective effect of betanin, a chemical compound found in the class of betacyanins on the liver.
In fish pretreated with 1, 2, and 4 % betanin in fodder throughout the experiment for 20 days before intraperitoneally injected with 20 % (v/v in peanut oil) CCl4 at a volume of 0.5 mL/kg body weight, researchers showed that* Injection of CCl4 induced liver injury by promoting the expression of liver CYP2E1 which has been found to increased in patient with liver disease, and oxidative stress.
* Elevated serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) activities and liver histological damage in CCl4 fish were also decreased in the treatment group.
More precisely, compared with the CCl4 control group, the betanin-treated groups exhibited reduced CYP2E1 activity, decreased malondialdehyde level, increased liver antioxidative capacity (increased glutathione level and superoxide dismutase and catalase activities).
In other words, all parameters associated with liver injury in the CCl4 group are inhibited by the administration of betanin.
Based on the finding, researchers said, " In conclusion, betanin attenuates CCl4-induced liver damage in common carp. Moreover, the inhibition of CYP2E1 activity and oxidative stress may have significant roles in the protective effect of betanin".
Taken altogether, betacyanins processed abundantly bioactive compound betanin may be considered a remedy for the prevention and treatment of liver injury, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.) by Han J1, Gao C, Yang S, Wang J, Tan D. (PubMed)
(2) Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury by Galati EM1, Mondello MR, Lauriano ER, Taviano MF, Galluzzo M, Miceli N.(PubMed)
(3) Alcohol-Related Complications by the Canadian Liver Association
Liver disease is a class of medical condition characterized by reducing partly or completely the function of the liver, including liver injury.
Most common symptoms of liver injury are totally depending on the severity of the injury that affects the liver function. In serious cases of liver injury, symptoms may include jaundice, pain in your upper right abdomen, abdominal swelling, gastrointestinal symptoms such as nausea and vomiting, disorientation or confusion and sleepiness.
Most common causes of liver injury include
* Overdose of certain medication, especially acetaminophen overdose. Believer, it or not, taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the US.
* Overdose of some prescription medications, including antibiotics, nonsteroidal anti-inflammatory drugs, and anticonvulsants is also associated with liver injury.
* Overdose of herbal extracts such as green tea ECG
* Toxins
Exposure to toxic chemicals such as refrigerants and solvents for waxes and eating toxic food such as wild mushroom may cause liver injury.
Out of many risk factors involved in liver injury, some researchers suggested alcohol intoxication, a condition of alcohol poisoning caused by excessively high levels of the recent drinking of ethanol in the blood (alcohol) may be one of the major culprits that cause the long-term injury to the liver.
Over time, excessive alcohol drinking can lead to fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis.
The Canadian Liver Association wrote, "When the liver has too much alcohol to handle, normal liver function may be interrupted leading to a chemical imbalance. If the liver is required to detoxify alcohol continuously, liver cells may be destroyed or altered resulting in fat deposits (fatty liver), and more seriously, either inflammation (alcoholic hepatitis), and/or permanent scarring (cirrhosis).
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the prevention of liver injury, researchers examined the protective effect of betanin, a chemical compound found in the class of betacyanins on the liver.
In fish pretreated with 1, 2, and 4 % betanin in fodder throughout the experiment for 20 days before intraperitoneally injected with 20 % (v/v in peanut oil) CCl4 at a volume of 0.5 mL/kg body weight, researchers showed that* Injection of CCl4 induced liver injury by promoting the expression of liver CYP2E1 which has been found to increased in patient with liver disease, and oxidative stress.
* Elevated serum aspartate aminotransferase (AST)/alanine aminotransferase (ALT) activities and liver histological damage in CCl4 fish were also decreased in the treatment group.
More precisely, compared with the CCl4 control group, the betanin-treated groups exhibited reduced CYP2E1 activity, decreased malondialdehyde level, increased liver antioxidative capacity (increased glutathione level and superoxide dismutase and catalase activities).
In other words, all parameters associated with liver injury in the CCl4 group are inhibited by the administration of betanin.
Based on the finding, researchers said, " In conclusion, betanin attenuates CCl4-induced liver damage in common carp. Moreover, the inhibition of CYP2E1 activity and oxidative stress may have significant roles in the protective effect of betanin".
Taken altogether, betacyanins processed abundantly bioactive compound betanin may be considered a remedy for the prevention and treatment of liver injury, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.) by Han J1, Gao C, Yang S, Wang J, Tan D. (PubMed)
(2) Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury by Galati EM1, Mondello MR, Lauriano ER, Taviano MF, Galluzzo M, Miceli N.(PubMed)
(3) Alcohol-Related Complications by the Canadian Liver Association
Friday, August 30, 2019
Phytochemical Alliin Promotes Balanced Ratio of Gut Microbiota
Inflammation is a natural response of the immune system with an aim to protect our body against the foreign micro pathogens which may infect the body tissue.
In the early phase of infection, after receiving the message from the central nervous system, the white blood cells of the immune first-line defense macrophages stimulate the production of blood palette to the cover the site of tissue damage and injury and inflammatory cytokines to destroy the microorganisms which try to enter the body through the wound.
Depending on the size of the injury, most small tissues damage are healed by itself within a day or weeks. In some cases, stitches may be needed.
However, if the immune system can not drive out all the invader in a period of 3-8 weeks, it will compromise, leading to low-grade inflammation.
Over time, long-term low-grade inflammation may cause tissue damage and alternation of cell DNA, leading to chronic diseases such as cardiovascular disease, diabetes, and cancer.
Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.
Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.
In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the protection of gut microbiota, researchers examined the effect of alliin (S-allyl-L-cysteine sulfoxide (ACSO)) on plasma ethanol concentration due to alcohol intake by accelerating ethanol metabolism and preventing ethanol absorption from the gut in rats.
Injection of high ACSO content (Garlic-H) suppressed elevation in concentrations of ethanol and acetaldehyde in plasma in the experimental rats without affecting much of the plasma acetate.
Furthermore, the inhibition of alcohol ethanol was attributed to the activity of alliin in the promotion of the activities of alcohol dehydrogenase and aldehyde dehydrogenase, a group of enzymes that catalyze the oxidation of aldehydes.
Compared to the absorption of ethanol from the stomach and jejunum, alliin ACSO and Garlic-H suppressed the absorption of ethanol from the stomach and jejunum, but the suppression in the jejunum was less than in the stomach.
In other words, alliin protects the gut microbiota by inhibiting ethanol absorption and accelerating ethanol metabolism.
In dextran sulfate sodium (DSS)-induced colitis mice and lipopolysaccharide-stimulated RAW264.7 cell model, oral administration of alliin at 500 mg/kg significantly inhibited the decrease of body weight, improved the DAI and decreased the infiltration of inflammatory cells in colonic tissues.
The levels of pro-inflammatory expressions and pro-inflammation activation proteins in the gut and content of NO, MDA, and MPO of gut stress markers were also inhibited by the injection alliin.
Based on the findings, researchers wrote, "Our results show that alliin ameliorates DSS-induced ulcerative colitis and inhibits the inflammatory responses in LPS-stimulated RAW264.7 cells partly".
Taken altogether, alliin may be considered supplements for the prevention and treatment of gut microbiota imbalanced as seen in colitis patients, pending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) S-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from gut by Uto-Kondo H1, Hase A2, Yamaguchi Y2, Sakurai A2, Akao M2, Saito T3, Kumagai H. (PubMed)
(2) Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation by Shi L1, Lin Q1, Li X2, Nie Y1, Sun S1, Deng X3, Wang L1, Lu J1, Tang Y1, Luo F. (PubMed)
In the early phase of infection, after receiving the message from the central nervous system, the white blood cells of the immune first-line defense macrophages stimulate the production of blood palette to the cover the site of tissue damage and injury and inflammatory cytokines to destroy the microorganisms which try to enter the body through the wound.
Depending on the size of the injury, most small tissues damage are healed by itself within a day or weeks. In some cases, stitches may be needed.
However, if the immune system can not drive out all the invader in a period of 3-8 weeks, it will compromise, leading to low-grade inflammation.
Over time, long-term low-grade inflammation may cause tissue damage and alternation of cell DNA, leading to chronic diseases such as cardiovascular disease, diabetes, and cancer.
Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.
Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.
In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the protection of gut microbiota, researchers examined the effect of alliin (S-allyl-L-cysteine sulfoxide (ACSO)) on plasma ethanol concentration due to alcohol intake by accelerating ethanol metabolism and preventing ethanol absorption from the gut in rats.
Injection of high ACSO content (Garlic-H) suppressed elevation in concentrations of ethanol and acetaldehyde in plasma in the experimental rats without affecting much of the plasma acetate.
Furthermore, the inhibition of alcohol ethanol was attributed to the activity of alliin in the promotion of the activities of alcohol dehydrogenase and aldehyde dehydrogenase, a group of enzymes that catalyze the oxidation of aldehydes.
Compared to the absorption of ethanol from the stomach and jejunum, alliin ACSO and Garlic-H suppressed the absorption of ethanol from the stomach and jejunum, but the suppression in the jejunum was less than in the stomach.
In other words, alliin protects the gut microbiota by inhibiting ethanol absorption and accelerating ethanol metabolism.
In dextran sulfate sodium (DSS)-induced colitis mice and lipopolysaccharide-stimulated RAW264.7 cell model, oral administration of alliin at 500 mg/kg significantly inhibited the decrease of body weight, improved the DAI and decreased the infiltration of inflammatory cells in colonic tissues.
The levels of pro-inflammatory expressions and pro-inflammation activation proteins in the gut and content of NO, MDA, and MPO of gut stress markers were also inhibited by the injection alliin.
Based on the findings, researchers wrote, "Our results show that alliin ameliorates DSS-induced ulcerative colitis and inhibits the inflammatory responses in LPS-stimulated RAW264.7 cells partly".
Taken altogether, alliin may be considered supplements for the prevention and treatment of gut microbiota imbalanced as seen in colitis patients, pending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) S-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from gut by Uto-Kondo H1, Hase A2, Yamaguchi Y2, Sakurai A2, Akao M2, Saito T3, Kumagai H. (PubMed)
(2) Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation by Shi L1, Lin Q1, Li X2, Nie Y1, Sun S1, Deng X3, Wang L1, Lu J1, Tang Y1, Luo F. (PubMed)
Subscribe to:
Posts (Atom)