Gastric, stomach ulcer is an oval sore found on the lining of the stomach.
A gastric ulcer is one of the most common types of peptic ulcer disease which affects both the stomach and small intestines.
According to the epidemiological studies, gastric ulcer is caused either by the infection of bacterium Helicobacter pylori (H. pylori) or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin.
Most common symptoms are burning sensation or pain in the stomach. Most patients with gastric ulcer have pain that intensifies on empty stomach, depending on the severity of the condition.
Some patients with gastric ulcer also experience persistent dull pain in the stomach, unintended weight loss, nausea or vomiting and bloating and acid reflux.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of a gastric ulcer.
Conventionally, most cases of gastric ulcer can be treated successfully depending on the cause, including medicine or surgery if the medicine failed.
Out of many risk factors that cause a gastric ulcer, some researchers suggested there is a correlation between obesity and gastritis as well as gastric ulcers.
Dr. Nadia B. Pietrzykowska said, "Excess body weight has been linked to various abdominal ailments. These may include abdominal pain, bloating, vomiting, heartburn, diarrhea or constipation".
And, "Scientific studies are also increasingly reporting a correlation between obesity and gastritis as well as gastric ulcers. A recent, large study that specifically focused on analyzing gastric and duodenal ulcers confirmed that excess weight predisposed individuals to gastric ulcers when compared to their normal-weight counterparts".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the testing of the effect of Vaccinium myrtillus L. anthocyanoside (VMA) used as a folk medicine to treat diseases related to gastric ulcers in northern Europe, researchers investigated the protective effects of VMA on gastric mucosal damage in a murine gastric ulcer model.
During the experiment, oral administration of VMA (10, 30 and 100 mg/kg) significantly protected gastric mucosa against HCl/ethanol-induced gastric ulcers.
VMA protected the stomach by inhibiting lipid peroxide levels in a concentration-dependent manner and exhibiting the high scavenging activity against the superoxide anion radical (·O(2) (-) ) and the hydroxyl radical (·OH).
The antioxidant activity in VMA was found to be attributed by the presence of anthocyanidins and delphinidin.
Based on the findings, Dr. Ogawa K, the lead scientist said, "These findings indicate that the protective effects of VMA on HCl/ethanol-induced gastric mucosal injury may be partially due to the antiperoxidative effects of anthocyanidins".
In order to provide more information about VMA gastric protective effects, researchers examined the antiulcer effects of 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-1-benzopyrylium chloride (IdB 1027,
an anthocyanidin from Vaccinium myrtillus) in various experimental models.
Orally, IdB 1027 inhibited all parameters associated with the onset of gastric ulcerations including anti-inflammatory drugs, ethanol, reserpine, histamine and duodenal ulceration induced by mercaptamine.
Furthermore, IdB 1027 also protected the stomach against chronic gastric ulcers induced by acetic acid.
Moreover, IdB 1027 in rat model did not affect gastric secretion in pylorus-ligated rats and increased gastric mucus in normal animals both in the absence and in the presence of indomethacin treatment.
In other words, IdB 1027 possessed a promising antiulcer activity, probably by potentiating the defensive barriers of the gastrointestinal mucosa.
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of gastric ulcer, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice by Ogawa K1, Oyagi A, Tanaka J, Kobayashi S, Hara H. (PubMed)
(2) Antiulcer activity of an anthocyanidin from Vaccinium myrtillus by Magistretti MJ1, Conti M, Cristoni A. (PubMed)
(3) Obesity and Gastric Ulcers by Dr. Nadia B. Pietrzykowska. (OMC community)
Monday, September 9, 2019
Sunday, September 8, 2019
Green Tea In Alleviated Symptoms, Risk, Progression and Treatment of Polymyalgia Arthritis (Rheumatica)
Green tea may have a therapeutic and positive effect in reduced symptoms, risk, progression and treatment of polymyalgia arthritis (rheumatica), some scientists suggested.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
Polymyalgia rheumatica is an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.
In an animal study of inflammatory diseases induced by injection of LPS, application of green tea bioactive polyphenols EGCG improved the antioxidant status of the host and decreased the production of inflammatory factors, including PMR through its antioxidant properties.
Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, swelling of the infectious site without affecting the function of the immune system in protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.
The bioactive compound also inhibited reactive oxygen species (ROS) in stimulated production of inflammatory cytokines through free radicals chain reactions in facilitated inflammation and precipitated skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue or activating catabolic signaling.
In fact, overproduction of ROS increased continuously expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases caused an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.
The further evaluation suggested that green tea EGCG reduced expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.
Long term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complication of several chronic inflammatory diseases through generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,
Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in regulated innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor-alpha (TNF-α) in promoted muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.
Importantly, the application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.
These actions together with antioxidant initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues and prevented muscle tension to precipitate polymyalgia arthritis.
Deficiency of glutathione levels was found to associate to the early development of Polymyalgia Arthritis in facilitated symptoms of pain, stiffness, achiness, fatigue, and fever.
Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drugs with function to target pro-inflammation cytokines in relieving stiffness and pain in patients with polymyalgia arthritis.
Taken together, Green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression and treatment of polymyalgia arthritis (rheumatica). However, ingestion green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
Polymyalgia rheumatica is an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.
In an animal study of inflammatory diseases induced by injection of LPS, application of green tea bioactive polyphenols EGCG improved the antioxidant status of the host and decreased the production of inflammatory factors, including PMR through its antioxidant properties.
Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, swelling of the infectious site without affecting the function of the immune system in protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.
The bioactive compound also inhibited reactive oxygen species (ROS) in stimulated production of inflammatory cytokines through free radicals chain reactions in facilitated inflammation and precipitated skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue or activating catabolic signaling.
In fact, overproduction of ROS increased continuously expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases caused an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.
The further evaluation suggested that green tea EGCG reduced expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.
Long term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complication of several chronic inflammatory diseases through generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,
Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in regulated innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor-alpha (TNF-α) in promoted muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.
Importantly, the application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.
These actions together with antioxidant initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues and prevented muscle tension to precipitate polymyalgia arthritis.
Deficiency of glutathione levels was found to associate to the early development of Polymyalgia Arthritis in facilitated symptoms of pain, stiffness, achiness, fatigue, and fever.
Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drugs with function to target pro-inflammation cytokines in relieving stiffness and pain in patients with polymyalgia arthritis.
Taken together, Green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression and treatment of polymyalgia arthritis (rheumatica). However, ingestion green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)
Lycopene Inhibits Skin Cancer Cells Spreading in Vitro
Skin cancer is a medical condition associated with irregular cell growth in the skin tissues.
Most cases of skin cancer start in the cells on the surface of the outermost inner lining tissue before penetrating into deeper layers.
After growing in size at the advanced stage, the cells of the tumor may travel a distance away to infect other healthy tissue and organs through blood and fluids circulation.
Most common secondary metastasis of skin cancer is breast, lung, and colon.
Believe it or not, more people are diagnosed with skin cancer each year in the U.S. than all other cancers combined. As of today, there are 58 million American are living with skin cancer.
Approximately, 1 in 5 Americans will develop skin cancer by the age of 70.
If you have experienced some of the symptoms such as a sore that doesn't heal or comes back after healing, a pale white or yellow flat areas that look like scars, raised and scaly red patches, small, smooth and shiny lumps that are pearly white, pink or red, a pink growth with raised edges and indents in the center and a growth that has small blood vessels on the surface of the skin, you may be on the early stage of skin cancer, please check with your doctor immediately.
The 5-year survival of among all people with melanoma of the skin is 92% compared to 100% of the localized skin cancer.
Out of many prevalent factors that cause skin cancer, some researchers suggested exposure to UVB are one most risk associated with skin cancer onset in the US.
Dr. Calzavara-Pinton P, the lead scientist said, "BCC is much more strongly related to measures of intermittent ultraviolet exposure (particularly those of childhood or adolescence) than to measures of cumulative exposure".
And, " In contrast, SCC is more strongly related to constant or cumulative sun exposure. Photobiological studies have clarified that sunlight and UVB radiation are complete carcinogens for AK and SCC although the relationship with UVA exposure is much less known".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
In the urgency to find a natural compound for the treatment of skin cancer without side effects, researchers evaluated the effect of lycopene, a kind of carotenoid inhibitory function on skin tumor cell migration.
In the human sSCC cell line COLO-16 selected to the study, administration of lycopene inhibited the cell proliferation and migration of COLO-16 cells without affecting the normal keratinocytes.
Furthermore, the inhibitory activity was found by exhibiting Zonula occludens (ZO)-1, inhibition of ZO-1 expression and its failure to accumulate at cell junctions (ZO-1 and claudin-1) have been found to induce cancer progression.
In other words, lycopene inhibited the SCC cell line COLO-16 proliferation by enhancing the expression of the tight junction complexes that regulate the permeability of epithelial against cancer cells.
Additionally, cell cycle division proteins (JNK and ERK ) in the induction of mitogen associated with the decreasing levels of ZO-1 and claudin-1 were also inhibited by the injection of lycopene.
More precisely, lycopene inhibited the progression of human sSCC cell line COLO-16 by reducing the proteins involved in promoting cell cycle division and increasing cancer cell permeability and autophagy,
Based on the findings researchers said, "This study indicates that lycopene might be a useful chemopreventive agent against cSCC".
Taken altogether, lycopene may be considered supplements for the prevention and treatment of skin cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16 by Bi S1,2, Li L1, Gu H1, Li M1, Xu S1, Bu W1, Zhang M1, Zhou Z2, Chen X. (PubMed)
(2) Suppressive effects of lycopene and β-carotene on the viability of the human esophageal squamous carcinoma cell line EC109 by Ngoc NB1,2, Lv P1,3, Zhao WE1. (PubMed)
Most cases of skin cancer start in the cells on the surface of the outermost inner lining tissue before penetrating into deeper layers.
After growing in size at the advanced stage, the cells of the tumor may travel a distance away to infect other healthy tissue and organs through blood and fluids circulation.
Most common secondary metastasis of skin cancer is breast, lung, and colon.
Believe it or not, more people are diagnosed with skin cancer each year in the U.S. than all other cancers combined. As of today, there are 58 million American are living with skin cancer.
Approximately, 1 in 5 Americans will develop skin cancer by the age of 70.
If you have experienced some of the symptoms such as a sore that doesn't heal or comes back after healing, a pale white or yellow flat areas that look like scars, raised and scaly red patches, small, smooth and shiny lumps that are pearly white, pink or red, a pink growth with raised edges and indents in the center and a growth that has small blood vessels on the surface of the skin, you may be on the early stage of skin cancer, please check with your doctor immediately.
The 5-year survival of among all people with melanoma of the skin is 92% compared to 100% of the localized skin cancer.
Out of many prevalent factors that cause skin cancer, some researchers suggested exposure to UVB are one most risk associated with skin cancer onset in the US.
Dr. Calzavara-Pinton P, the lead scientist said, "BCC is much more strongly related to measures of intermittent ultraviolet exposure (particularly those of childhood or adolescence) than to measures of cumulative exposure".
And, " In contrast, SCC is more strongly related to constant or cumulative sun exposure. Photobiological studies have clarified that sunlight and UVB radiation are complete carcinogens for AK and SCC although the relationship with UVA exposure is much less known".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
In the urgency to find a natural compound for the treatment of skin cancer without side effects, researchers evaluated the effect of lycopene, a kind of carotenoid inhibitory function on skin tumor cell migration.
In the human sSCC cell line COLO-16 selected to the study, administration of lycopene inhibited the cell proliferation and migration of COLO-16 cells without affecting the normal keratinocytes.
Furthermore, the inhibitory activity was found by exhibiting Zonula occludens (ZO)-1, inhibition of ZO-1 expression and its failure to accumulate at cell junctions (ZO-1 and claudin-1) have been found to induce cancer progression.
In other words, lycopene inhibited the SCC cell line COLO-16 proliferation by enhancing the expression of the tight junction complexes that regulate the permeability of epithelial against cancer cells.
Additionally, cell cycle division proteins (JNK and ERK ) in the induction of mitogen associated with the decreasing levels of ZO-1 and claudin-1 were also inhibited by the injection of lycopene.
More precisely, lycopene inhibited the progression of human sSCC cell line COLO-16 by reducing the proteins involved in promoting cell cycle division and increasing cancer cell permeability and autophagy,
Based on the findings researchers said, "This study indicates that lycopene might be a useful chemopreventive agent against cSCC".
Taken altogether, lycopene may be considered supplements for the prevention and treatment of skin cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16 by Bi S1,2, Li L1, Gu H1, Li M1, Xu S1, Bu W1, Zhang M1, Zhou Z2, Chen X. (PubMed)
(2) Suppressive effects of lycopene and β-carotene on the viability of the human esophageal squamous carcinoma cell line EC109 by Ngoc NB1,2, Lv P1,3, Zhao WE1. (PubMed)
Saturday, September 7, 2019
Bromelain Protects the Cell DNA Against Genotoxicity
Genotoxicity is a process of destruction on a cell's genetic material (DNA, RNA), leading to gene mutation.
In other words, genotoxins are mutagens, the substances which have been found to induce cancer. Most common genotoxins are radiation and toxic chemicals.
Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage the germ cell.
Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.
Most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.
By regulating the levels of free radicals in the body through the increased antioxidant enzyme inside the host or from the dietary sources, oxidative stress induced by ROS may be controlled. Thereby, reducing the risk of gene damage.
Dr. Mohamed SAKS, the lead scientist wrote in the article published in the Global Journal of Pharmacy & Pharmaceutical Sciences, "There are mainly two mechanisms of anti-mutagenesis:
a. Desmutagenesis in which the factors on the mutagens are somehow inactivated,
b. Bio-antimutagenesis, in which the factors act on the process of mutagenesis or by repairing the damaged DNA that results in the decreased frequency of DNA mutation [15]. a number of cells have a DNA repair system by which they try to control the DNA mutations naturally".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential treatment cancer, researchers examined the genotoxic effect of
pineapple extract on oral cancer cell line by DNA fragmentation.
According to the DNA fragmentation assay, bromelain showed a significantly genotoxic activity by invading the cancer nucleus and causes damage to the nucleic acid.
In the examine 3 different doses of bromelain incubated with oral cancer cells, DNA fragmentation occurred in all three concentrations.
In other words, bromelain inhibited oral cancer cell progression through genotoxic properties.
Furthermore, bromelain also inhibited the expression of MUC1, a glycoprotein associated with tumor cells invasive, metastatic, and chemo-resistant properties in breast and pancreatic cancer cells.
Moreover, bromelain used a combination with either cisplatin and 5-FU also enhanced conventional medicine efficacy.
Additionally, in malignant peritoneal mesothelioma (MPM) expressed MUC1, administration of bromelain also affected the viability of MPM cells adversely.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of cancer through its genotoxic activity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Genotoxicity analysis of pineapple extract on oral cancer cell line by DNA fragmentation by A.A. Mahtani, R. Gayathri, and V. Vishnu Priya. (Research Gate)
(2) Anticancer Property of Bromelain With Therapeutic Potential in Malignant Peritoneal Mesothelioma by Krishna Pillai, Javed Akhter, Terence C Chua & David Lawson Morris. (Taylor and Francis Online)
(3) Genotoxicity: Mechanisms, Testing Guidelines and Methods by Mohamed SAKS, Sabita Upreti, Rajendra SV* and Raman Dang. (the Global Journal of Pharmacy & Pharmaceutical Sciences)
In other words, genotoxins are mutagens, the substances which have been found to induce cancer. Most common genotoxins are radiation and toxic chemicals.
Believe it or not, besides causing cancer, genotoxins are found to induce various types of genetic diseases, by the damage the germ cell.
Some researchers suggested that the damage of DNA may be controlled if the genotoxins are identified through the use of anti antimutagens /anti-clastogens that suppress or inhibit the mutagenesis process.
Most common causes of genetic damage or alternation are reactive oxygen species (ROS), the unstable and genotoxic molecules that exist everywhere in the environment and inside the human body.
By regulating the levels of free radicals in the body through the increased antioxidant enzyme inside the host or from the dietary sources, oxidative stress induced by ROS may be controlled. Thereby, reducing the risk of gene damage.
Dr. Mohamed SAKS, the lead scientist wrote in the article published in the Global Journal of Pharmacy & Pharmaceutical Sciences, "There are mainly two mechanisms of anti-mutagenesis:
a. Desmutagenesis in which the factors on the mutagens are somehow inactivated,
b. Bio-antimutagenesis, in which the factors act on the process of mutagenesis or by repairing the damaged DNA that results in the decreased frequency of DNA mutation [15]. a number of cells have a DNA repair system by which they try to control the DNA mutations naturally".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential treatment cancer, researchers examined the genotoxic effect of
pineapple extract on oral cancer cell line by DNA fragmentation.
According to the DNA fragmentation assay, bromelain showed a significantly genotoxic activity by invading the cancer nucleus and causes damage to the nucleic acid.
In the examine 3 different doses of bromelain incubated with oral cancer cells, DNA fragmentation occurred in all three concentrations.
In other words, bromelain inhibited oral cancer cell progression through genotoxic properties.
Furthermore, bromelain also inhibited the expression of MUC1, a glycoprotein associated with tumor cells invasive, metastatic, and chemo-resistant properties in breast and pancreatic cancer cells.
Moreover, bromelain used a combination with either cisplatin and 5-FU also enhanced conventional medicine efficacy.
Additionally, in malignant peritoneal mesothelioma (MPM) expressed MUC1, administration of bromelain also affected the viability of MPM cells adversely.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of cancer through its genotoxic activity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Genotoxicity analysis of pineapple extract on oral cancer cell line by DNA fragmentation by A.A. Mahtani, R. Gayathri, and V. Vishnu Priya. (Research Gate)
(2) Anticancer Property of Bromelain With Therapeutic Potential in Malignant Peritoneal Mesothelioma by Krishna Pillai, Javed Akhter, Terence C Chua & David Lawson Morris. (Taylor and Francis Online)
(3) Genotoxicity: Mechanisms, Testing Guidelines and Methods by Mohamed SAKS, Sabita Upreti, Rajendra SV* and Raman Dang. (the Global Journal of Pharmacy & Pharmaceutical Sciences)
Carotenoids, Inhibits the Risk and Progression of Prostate Cancer
The prostate warped around the urethra is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.
Prostate cancer is a medical and chronic condition caused by cells growth irregular in the prostate gland. Most cases of prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Most cases of prostate cancer begin in the cells on the surface of the inner lining of the prostate tissue before penetrating into deeper layers to induce colonization.
At the advanced stage, the prostate cancer cells can spread to the distant parts of the body, leading to secondary metastasis.
Prostate cancer can be diagnosed by* Blood tests
* Digital Rectal Examination (DRE)
In DRE, your doctor inserts a lubricated, gloved finger into the rectum to feel the surface of the prostate gland to check for any abnormality of the prostate.
* Transrectal Ultrasound (TRUS)
Ultrasound allows your doctor to visualize and assess the size of your prostate and to check for any abnormality and surrounding area with an image taken from the test. In transrectal ultrasound, a probe is inserted into the rectum to emit ultrasonic impulses against the prostate.
* Prostate-specific antigen (PSA) test
The test is to measure the levels of prostate-specific antigen (PSA), a protein produced by the prostate. The high levels of PSA may be an indication of higher risk of the presence of prostate cancer.
* Prostatic Acid Phosphatase (PAP) test
Prostatic acid phosphatase (PAP) is a test to measure the level of prostatic acid phosphatase, an enzyme produced by the prostate. The higher the levels of PAP is an indication of the disease progression.
* Prostate biopsy
In a prostate biopsy, samples of the prostate are taken by a thin, tube-like instrument to examine under microscopy to review the stage of cancer.
According to the statistics, prostate cancer is the most common cancer among men particularly in older over 65, after skin cancer. in 2019, approximately 174,650 men in the US will be diagnosed with prostate cancer.
The average age of diagnosis is 66.
Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the prevention and treatment of prostate cancer, researchers examined the effect of carotenoid levels on the risk of high-grade prostate cancer.
The study included the measurement of plasma levels of carotenoids and genotyped 20 single nucleotide polymorphisms (SNP) in SOD1, SOD2, SOD3, XRCC1, and OGG1 in 559 men with non-metastatic prostate cancer undergoing radical prostatectomy.
According to the results from tested assays, the serum of circulated carotenoid levels was inversely associated with the risk of high-grade prostate cancer, odds ratios (OR) of 0.34 compared to the highest versus lowest quartiles.
In chemical analysis, the relative odds ratio of α-carotene,β-carotene, lycopene, and total carotenoids.was 0.31, .55, 34, and 0.37 respectively.
In other words, all major phytochemicals found in carotenoid work synergistically to enhance the efficacy of carotenoid against the risk of high-grade prostate cancer.
Furthermore, the presence of the SNPs rs25489 in XRCC1, rs699473 in SOD3 and rs1052133 in OGG1 genotypes also was found to modify the activity of α-carotene, β-carotene, and lycopene, respectively.
Believe it or not, the high serum of lycopene was found among men with Gleason score ≤ 3 + 4 and lower FGA (P = 0.04).
More precisely, the efficacy of carotenoid reduced the risk of prostate cancer, however, the risk of high-grade invasive prostate cancer are depending on the levels of lycopene.
Dr. Nordström T, the lead scientist said, " higher lycopene level was associated with less genomic instability among men with the low-grade disease which is novel and supports the hypothesis that lycopene may inhibit the progression of prostate cancer early in its natural history".
Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoid in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer by Nordström T1,2,3, Van Blarigan EL1,2, Ngo V1, Roy R4, Weinberg V5, Song X6, Simko J1,7, Carroll PR1, Chan JM1,2, Paris PL. (PubMed)
(2) Anticancer properties of carotenoids in prostate cancer. A review by Soares Nda C1, Teodoro AJ2, Lotsch PF3, Granjeiro JM3, Borojevic R. (PubMed)
(3) Prostate Cancer by Kyle J, Norton
Prostate cancer is a medical and chronic condition caused by cells growth irregular in the prostate gland. Most cases of prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Most cases of prostate cancer begin in the cells on the surface of the inner lining of the prostate tissue before penetrating into deeper layers to induce colonization.
At the advanced stage, the prostate cancer cells can spread to the distant parts of the body, leading to secondary metastasis.
Prostate cancer can be diagnosed by* Blood tests
* Digital Rectal Examination (DRE)
In DRE, your doctor inserts a lubricated, gloved finger into the rectum to feel the surface of the prostate gland to check for any abnormality of the prostate.
* Transrectal Ultrasound (TRUS)
Ultrasound allows your doctor to visualize and assess the size of your prostate and to check for any abnormality and surrounding area with an image taken from the test. In transrectal ultrasound, a probe is inserted into the rectum to emit ultrasonic impulses against the prostate.
* Prostate-specific antigen (PSA) test
The test is to measure the levels of prostate-specific antigen (PSA), a protein produced by the prostate. The high levels of PSA may be an indication of higher risk of the presence of prostate cancer.
* Prostatic Acid Phosphatase (PAP) test
Prostatic acid phosphatase (PAP) is a test to measure the level of prostatic acid phosphatase, an enzyme produced by the prostate. The higher the levels of PAP is an indication of the disease progression.
* Prostate biopsy
In a prostate biopsy, samples of the prostate are taken by a thin, tube-like instrument to examine under microscopy to review the stage of cancer.
According to the statistics, prostate cancer is the most common cancer among men particularly in older over 65, after skin cancer. in 2019, approximately 174,650 men in the US will be diagnosed with prostate cancer.
The average age of diagnosis is 66.
Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the prevention and treatment of prostate cancer, researchers examined the effect of carotenoid levels on the risk of high-grade prostate cancer.
The study included the measurement of plasma levels of carotenoids and genotyped 20 single nucleotide polymorphisms (SNP) in SOD1, SOD2, SOD3, XRCC1, and OGG1 in 559 men with non-metastatic prostate cancer undergoing radical prostatectomy.
According to the results from tested assays, the serum of circulated carotenoid levels was inversely associated with the risk of high-grade prostate cancer, odds ratios (OR) of 0.34 compared to the highest versus lowest quartiles.
In chemical analysis, the relative odds ratio of α-carotene,β-carotene, lycopene, and total carotenoids.was 0.31, .55, 34, and 0.37 respectively.
In other words, all major phytochemicals found in carotenoid work synergistically to enhance the efficacy of carotenoid against the risk of high-grade prostate cancer.
Furthermore, the presence of the SNPs rs25489 in XRCC1, rs699473 in SOD3 and rs1052133 in OGG1 genotypes also was found to modify the activity of α-carotene, β-carotene, and lycopene, respectively.
Believe it or not, the high serum of lycopene was found among men with Gleason score ≤ 3 + 4 and lower FGA (P = 0.04).
More precisely, the efficacy of carotenoid reduced the risk of prostate cancer, however, the risk of high-grade invasive prostate cancer are depending on the levels of lycopene.
Dr. Nordström T, the lead scientist said, " higher lycopene level was associated with less genomic instability among men with the low-grade disease which is novel and supports the hypothesis that lycopene may inhibit the progression of prostate cancer early in its natural history".
Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of prostate cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoid in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer by Nordström T1,2,3, Van Blarigan EL1,2, Ngo V1, Roy R4, Weinberg V5, Song X6, Simko J1,7, Carroll PR1, Chan JM1,2, Paris PL. (PubMed)
(2) Anticancer properties of carotenoids in prostate cancer. A review by Soares Nda C1, Teodoro AJ2, Lotsch PF3, Granjeiro JM3, Borojevic R. (PubMed)
(3) Prostate Cancer by Kyle J, Norton
Friday, September 6, 2019
Whole Food Tomato Balances the Ratio of Intestinal Microbiomes in the Gut
Intestinal microbiome is the community of bacteria living in the gut. Under normal conditions, the ratio of good and bad microbiomes are balanced.
Believe it or not, our GI-tract harbors one of the most complex and abundant ecosystems colonized by more than 100 trillion microorganisms, including Firmicutes and Bacteroidetes.
The composition and functions of the microbiome also have been found to influence by a number of factors including genetics, diet, age, and medical treatments such as antibiotics.
Epidemiological studies suggested that unbalanced of the ratio of bacterias in the GI tract due to the aforementioned factors also induce changes in microbiome structure, that links to inflammatory, functional and metabolic disorders such as IBD, IBS, and obesity.
Dr. Ana M Valdes, the lead scientist in the examined the health benefits associated with intestinal microbiome suggested that gut microbes have a strong effect on human health including immune, metabolic and neurobehavioral traits.
More precisely, the intestinal microbiomes
* Interact with the immune function against inflammatory immune disorders.
* Reduce the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
* Increase nutrient absorption from the diet, thus reducing the risk of obesity and obese complications.
* Control brain insulin signaling and metabolite levels against neurobehaviors.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to discover healthy food for the treatment of intestinal microbiome imbalance, researchers investigated the possibility of a dietary-induced switch to the gut microbiota composition.
The study included Winnie mice induced ulcerative colitis by treatment of chow enriched with 1% Bronze tomato.
According to the tested results, Bronze-enriched chow showed no macroscopic effect on the IBD symptoms after 2 weeks of administration. However, injection of bronze tomato exerted a significant effect on the production of anti-inflammatory cytokines and reduced levels of pro-inflammatory production in the same periods in ulcerative colitis mice.
Furthermore, the analysis of the microbial composition suggested that Bronze enriched diet demonstrated a strong effect on the microbial composition of Winnie and control mice by increasing levels of good bacteria in the gut.
According to the chemical analysis, the effect bronze tomato in improving the ratio of intestinal microbiome composition was attributed to the polyphenol-enriched diets in creating unfavorable conditions for bad bacterial species.
Another study conducted by the University of Arkansas at Little Rock to examined the effect of tomato fruits derived from plants exposed to multi-walled carbon nanotubes (CNTs) on gastrointestinal epithelial barrier integrity and their impact on the human commensal intestinal microbiota, in vitro cell culture and batch human fecal suspension models also suggested that
* At 0.001 μg ml-1 concentration, CNT-containing fruits showed insignificantly activity on the model T-84 human intestinal epithelial cells.
* However, at 10 μg ml-1 concentration, CNTs showed a strong effect in penetrating the cell membrane and change the gene expression profile of exposed tested cells.
Taken altogether, tomato processed multi-walled carbon nanotubes (CNTs) may be considered a dietary supplements for balancing the ratio of intestinal microbiota, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions by Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(2) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
Believe it or not, our GI-tract harbors one of the most complex and abundant ecosystems colonized by more than 100 trillion microorganisms, including Firmicutes and Bacteroidetes.
The composition and functions of the microbiome also have been found to influence by a number of factors including genetics, diet, age, and medical treatments such as antibiotics.
Epidemiological studies suggested that unbalanced of the ratio of bacterias in the GI tract due to the aforementioned factors also induce changes in microbiome structure, that links to inflammatory, functional and metabolic disorders such as IBD, IBS, and obesity.
Dr. Ana M Valdes, the lead scientist in the examined the health benefits associated with intestinal microbiome suggested that gut microbes have a strong effect on human health including immune, metabolic and neurobehavioral traits.
More precisely, the intestinal microbiomes
* Interact with the immune function against inflammatory immune disorders.
* Reduce the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
* Increase nutrient absorption from the diet, thus reducing the risk of obesity and obese complications.
* Control brain insulin signaling and metabolite levels against neurobehaviors.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to discover healthy food for the treatment of intestinal microbiome imbalance, researchers investigated the possibility of a dietary-induced switch to the gut microbiota composition.
The study included Winnie mice induced ulcerative colitis by treatment of chow enriched with 1% Bronze tomato.
According to the tested results, Bronze-enriched chow showed no macroscopic effect on the IBD symptoms after 2 weeks of administration. However, injection of bronze tomato exerted a significant effect on the production of anti-inflammatory cytokines and reduced levels of pro-inflammatory production in the same periods in ulcerative colitis mice.
Furthermore, the analysis of the microbial composition suggested that Bronze enriched diet demonstrated a strong effect on the microbial composition of Winnie and control mice by increasing levels of good bacteria in the gut.
According to the chemical analysis, the effect bronze tomato in improving the ratio of intestinal microbiome composition was attributed to the polyphenol-enriched diets in creating unfavorable conditions for bad bacterial species.
Another study conducted by the University of Arkansas at Little Rock to examined the effect of tomato fruits derived from plants exposed to multi-walled carbon nanotubes (CNTs) on gastrointestinal epithelial barrier integrity and their impact on the human commensal intestinal microbiota, in vitro cell culture and batch human fecal suspension models also suggested that
* At 0.001 μg ml-1 concentration, CNT-containing fruits showed insignificantly activity on the model T-84 human intestinal epithelial cells.
* However, at 10 μg ml-1 concentration, CNTs showed a strong effect in penetrating the cell membrane and change the gene expression profile of exposed tested cells.
Taken altogether, tomato processed multi-walled carbon nanotubes (CNTs) may be considered a dietary supplements for balancing the ratio of intestinal microbiota, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions by Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(2) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
Betacyanins, the Anti Liver Steatosis Phytochemical
The liver is the largest internal organ that not only filters the blood coming from the intestinal system but also protects our body against chemical and drug toxicity.
Additionally, the liver also produces cholesterol that plays an essential role to aid digestion, produce vitamin D and steroid hormone and build strong cell membranes.
Believe it or not, the liver also produces antioxidant enzymes which inhibit free radical oxidation and interact with the hormone insulin to store glucose in the form of glycogen.
Hepatic steatosis is a condition caused by the accumulation of fat in the liver. Liver steatosis can be classified into 2 types
* Alcoholic liver steatosis is caused by over-consumption of alcohol over time.
* Non-Alcohol Steatosis (NASH) is a condition of accumulation of excess fat in the liver in people who drink little or no alcohol. ... Non-Alcohol Steatosis is considered a major cause of liver scarring and cirrhosis.
Most common symptoms of liver steatosis are jaundice, abdominal swelling (ascites), enlarged blood vessels just beneath the skin's surface, enlarged breasts in men, enlarged spleen and red palms.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Conventionally, there is no effective treatment for liver steatosis. Weight loss and weight management through a combination of a healthy diet and exercise are the most recommendations.
Some researchers suggested that the rise of liver steatosis in the US may be correlated to the promotion of a high-fat diet over the past few decades.
Dr. Arisqueta L, the lead scientist wrote, "High-fat diet (HFD) feeding or leptin-deficient mice are extensively used as models resembling features of human nonalcoholic fatty liver disease (NAFLD)".
And, "The concurrence of experimental factors as fat content and source or total caloric intake leads to prominent differences in the development of the hepatic steatosis and related disturbances".
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural pigment for the prevention and treatment of liver steatosis, researchers examined whether betanin (from natural pigments, a member of betacyanins) anti-oxidant properties against paraquat-induced liver injury in Sprague-Dawley rats.
Paraquat injected intraperitoneally into rats to induce liver toxicity randomly assigned to 4 groups: a control group, a paraquat group, and two groups received betanin at doses of 25 and 100mg/kg/day three days before and two days after administered paraquat.
Administration of betanin inhibited the elevated serum aspartate aminotransferase and alanine aminotransferase levels of the paraquat rats.
Betanin treated group also enhanced the production of antioxidant enzymes that counter the overexpression of free radicals induced oxidative stress.
Furthermore, betanin treated group also increased the expression of an enzyme associated with detoxification.
Moreover, liver mitochondrial damage caused by paraquat injection also was reduced by the administration of betanin.
In other words, all parameters associated with the onset of liver damage that causes steatosis developing were decreased substantially in the animals treated with betanin than in those who received paraquat alone.
Based on the results, researchers after taking other factors into account wrote, "Betanin had a protective effect against paraquat-induced liver damage in rats. The mechanism of the protection appears to be the inhibition of CYP 3A2 expression and protection of mitochondria".
Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Red pitaya betacyanins protect from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice by Song H1,2, Chu Q1, Yan F1, Yang Y1, Han W1, Zheng X. (PubMed)
(2) White Pitaya (Hylocereus undatus) Juice Attenuates Insulin Resistance and Hepatic Steatosis in Diet-Induced Obese Mice by Song H1,2, Zheng Z1, Wu J1, Lai J1, Chu Q1, Zheng X. (PubMed)
(3) High-fat diet overfeeding promotes nondetrimental liver steatosis in female mice by Arisqueta L1, Navarro-Imaz H2, Labiano I3, Rueda Y2, Fresnedo O. (PubMed)
Additionally, the liver also produces cholesterol that plays an essential role to aid digestion, produce vitamin D and steroid hormone and build strong cell membranes.
Believe it or not, the liver also produces antioxidant enzymes which inhibit free radical oxidation and interact with the hormone insulin to store glucose in the form of glycogen.
Hepatic steatosis is a condition caused by the accumulation of fat in the liver. Liver steatosis can be classified into 2 types
* Alcoholic liver steatosis is caused by over-consumption of alcohol over time.
* Non-Alcohol Steatosis (NASH) is a condition of accumulation of excess fat in the liver in people who drink little or no alcohol. ... Non-Alcohol Steatosis is considered a major cause of liver scarring and cirrhosis.
Most common symptoms of liver steatosis are jaundice, abdominal swelling (ascites), enlarged blood vessels just beneath the skin's surface, enlarged breasts in men, enlarged spleen and red palms.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Conventionally, there is no effective treatment for liver steatosis. Weight loss and weight management through a combination of a healthy diet and exercise are the most recommendations.
Some researchers suggested that the rise of liver steatosis in the US may be correlated to the promotion of a high-fat diet over the past few decades.
Dr. Arisqueta L, the lead scientist wrote, "High-fat diet (HFD) feeding or leptin-deficient mice are extensively used as models resembling features of human nonalcoholic fatty liver disease (NAFLD)".
And, "The concurrence of experimental factors as fat content and source or total caloric intake leads to prominent differences in the development of the hepatic steatosis and related disturbances".
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural pigment for the prevention and treatment of liver steatosis, researchers examined whether betanin (from natural pigments, a member of betacyanins) anti-oxidant properties against paraquat-induced liver injury in Sprague-Dawley rats.
Paraquat injected intraperitoneally into rats to induce liver toxicity randomly assigned to 4 groups: a control group, a paraquat group, and two groups received betanin at doses of 25 and 100mg/kg/day three days before and two days after administered paraquat.
Administration of betanin inhibited the elevated serum aspartate aminotransferase and alanine aminotransferase levels of the paraquat rats.
Betanin treated group also enhanced the production of antioxidant enzymes that counter the overexpression of free radicals induced oxidative stress.
Furthermore, betanin treated group also increased the expression of an enzyme associated with detoxification.
Moreover, liver mitochondrial damage caused by paraquat injection also was reduced by the administration of betanin.
In other words, all parameters associated with the onset of liver damage that causes steatosis developing were decreased substantially in the animals treated with betanin than in those who received paraquat alone.
Based on the results, researchers after taking other factors into account wrote, "Betanin had a protective effect against paraquat-induced liver damage in rats. The mechanism of the protection appears to be the inhibition of CYP 3A2 expression and protection of mitochondria".
Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Red pitaya betacyanins protect from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice by Song H1,2, Chu Q1, Yan F1, Yang Y1, Han W1, Zheng X. (PubMed)
(2) White Pitaya (Hylocereus undatus) Juice Attenuates Insulin Resistance and Hepatic Steatosis in Diet-Induced Obese Mice by Song H1,2, Zheng Z1, Wu J1, Lai J1, Chu Q1, Zheng X. (PubMed)
(3) High-fat diet overfeeding promotes nondetrimental liver steatosis in female mice by Arisqueta L1, Navarro-Imaz H2, Labiano I3, Rueda Y2, Fresnedo O. (PubMed)
Subscribe to:
Posts (Atom)