Obesity is a chronic condition characterized by excess body fat has accumulated over time. People with a BMI of over 30 is considered obese.
Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is considered overweight.
According to the statistics, 68% of the American population is either overweight or obese. Obesity has been found to induce adverse effects nearly every system of the human body, leading to increased risk of numerous diseases, including diabetes and cardiovascular disease.
Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country economy and health care system.
Epidemiologically, most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation
According to the CDC, most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of breast, colon, endometrial, gallbladder, kidney, and liver and sleep apnea.
Currently, there is no effective treatment of the disease. However, some researchers suggested that combat the powerful environmental factors that influence eating and physical activity may be the best approach to reduce the risk of obesity.
Bariatric surgery is used as an option for management that causes a reduction in the amount of food you are or a reduction in the absorption of calories from the food you eat, or both.
The surgery has been proposed to patients with extreme obesity (BMI of 40 or higher) due to weight-induced a serious weight-related health problem, such as diabetes or high blood pressure.
Furthermore, this type of surgery has posed a serious risk of many patients if the commitment of making lifelong changes in eating and exercise habits cannot be followed through.
Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.
With an aim to find a natural food for the prevention and treatment of obesity, researchers examined the effect of sulforaphane found abundantly in collard greens.
In a high-fat diet (HFD)-induced obesity in C57BL/6N mice which were fed a normal diet (ND), HFD or HFD plus 0.1% sulforaphane (SFN) for 6 weeks, researchers found that SFN administration not only attenuated HFD-induced visceral adiposity that stored around a number of important internal organs such as the liver, pancreas and intestines, adipocyte hypertrophy associated with an enlargement of adipose tissue but also ameliorated fat accumulation in the liver.
Furthermore, SFN decreased the elevated levels of serum total cholesterol and leptin, and liver triglyceride in HFD-SFN-fed mice compared to HFD-fed mice.
SFN also inhibited the expression of a gene associated with the promotion of inflammation in the adipose tissue of HFD-SFN mice and increased the adiponectin function in regulating glucose levels and fatty acid breakdown.
Moreover, reductase expression associated with the production of cholesterol was decreased and an antibody associated with fatty acid utilization was increased in lycopene treat group compared with HFD-fed mice.
Taken altogether, collard green processed abundantly SFN may be considered supplements for the prevention and treatment of obesity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential effects of sulforaphane to fight obesity by Martins T1, Colaço B1,2, Venâncio C1,2, Pires MJ1,3, Oliveira PA1,3, Rosa E1, Antunes LM. (PubMed)
(2) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Kyeong-Mi Choi, Youn-Sun Lee, Wonkyun Kima, Seung Jung Kimb, Kyong-Oh Shina, Ji-YeonYuc, Mi Kyeong Lee, Yong-Moon Lee, Jin Tae Honga, Yeo-PyoYuna, Hwan-SooYooa. (Science Direct)
Wednesday, September 18, 2019
Tuesday, September 17, 2019
Herbal Bilberry, the Best in the Prevention and treatment of Type 2 Diabetes
On seeking natural therapy with no side effects, scientists may have a whole berry for the treatment of type 2 diabetes, according to studies.
Type 2 diabetes is a medical condition caused by not enough insulin entering the bloodstream to convert blood glucose into energy. Insulin resistance is a hallmark of patients with the disease.
Insulin is a hormone with a function to regulate the movement of sugar into your cells. In other words, insulin converts sugar to energy to fuel the body needs.
Most cases of type 2 diabetes is a result of not enough insulin produced by the pancreas due to reduced numbers of healthy beta cells or the insulin produced was not used properly due to the clogged up of the insulin receptor sites.
Type 2 diabetes is an acquired disease in adulthood. In the Western world, most cases of type 2 diabetes are associated with obesity induced by a long-term poor diet and lack of exercise.
Truly enough, over 68% of the population in the US are either overweight or obese.
According to the statistics in the US, in 2015, 30.3 million Americans or 9.4 percent of the U.S. population and another 84.1 million had confirmed diabetes and prediabetes, respectively.
Sadly, the majority of people with prediabetes don't know they had it.
Therefore, losing weight, eating well and moderate exercise daily can help to manage the disease against the onset of hyperglycemia, a major cause of the diabetic complication.
People with type 2 diabetes who can not manage the disease through weight loss, healthy diet and exercise are commonly treated with medications or insulin therapy.
Please make sure you know all the side effects if you are currently taking any form of therapies for diabetic treatment.
Most common symptoms of type 2 diabetes depending on the severity of the stages include increased thirst, frequent urination, unintended weight loss, and fatigue,
In severe cases, patients may also experience symptoms wound that does heal, blurred vision and frequent infections and areas of darkened skin.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding potential ingredients from the treatment of type 2 diabetes, researchers examined the bilberry content of anthocyanins and polyphenols which have been proven to process antidiabetic activity in several studies.
Injection of anthocyanins and polyphenols exhibited an increase in insulin secretion (anthocyanin pelargonidin), reduction of insulin resistance (anthocyanin cyanidin-3-glucoside), and glucose resorption from the GIT (polyphenols) and enhancement of beta-cells regeneration associated with the diabetics.
In the examination of the single ingredient anthocyanins, researchers found the compounds also contribute to the improvement of the lipid spectrum compared to that of acarbose and atorvastatin, according to many preclinical and clinical studies.
Furthermore, the compound derivatives anthocyanin cyanidin-3-galactoside also have antioxidant, anti-inflammatory and cardioprotective activities.
In order to reveal more information about bilberry antidiabetic effects, researchers at the joint study led by the University of Eastern Finland differentiated the serum hippuric acid changes after intake of bilberry.
In a total of 47 individuals with features of the metabolic syndrome, randomly assigned to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12).comapred to from fasting serum samples at baseline and after an 8-week intervention, researchers showed that fasting serum hippuric acid increased significantly (3.5-fold) only in the BB group and correlated with changes in fasting plasma glucose concentration and insulin secretion.
These results suggested bilberry anti-diabetic property not only confirms the Finnish Diabetes Prevention Study but also improves glycemic control and pancreas β-cell function which is reduced in patients with type 2 diabetes.
Dr. the lead scientist wrote after taking into account co and confounders in the final report, "Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the treatment of type 2 diabetes with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes by de Mello VD1, Lankinen MA1, Lindström J2, Puupponen-Pimiä R3, Laaksonen DE4, Pihlajamäki J1,5, Lehtonen M6,7, Uusitupa M1,8, Tuomilehto J2,9,10, Kolehmainen M1, Törrönen R1, Hanhineva K. (PubMed)
(2) [Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitusBillberry (Vaccinium myrtillus)].[Article in Czech] by Koupý D, Kotolová H, Kučerová J. (PubMed)
Type 2 diabetes is a medical condition caused by not enough insulin entering the bloodstream to convert blood glucose into energy. Insulin resistance is a hallmark of patients with the disease.
Insulin is a hormone with a function to regulate the movement of sugar into your cells. In other words, insulin converts sugar to energy to fuel the body needs.
Most cases of type 2 diabetes is a result of not enough insulin produced by the pancreas due to reduced numbers of healthy beta cells or the insulin produced was not used properly due to the clogged up of the insulin receptor sites.
Type 2 diabetes is an acquired disease in adulthood. In the Western world, most cases of type 2 diabetes are associated with obesity induced by a long-term poor diet and lack of exercise.
Truly enough, over 68% of the population in the US are either overweight or obese.
According to the statistics in the US, in 2015, 30.3 million Americans or 9.4 percent of the U.S. population and another 84.1 million had confirmed diabetes and prediabetes, respectively.
Sadly, the majority of people with prediabetes don't know they had it.
Therefore, losing weight, eating well and moderate exercise daily can help to manage the disease against the onset of hyperglycemia, a major cause of the diabetic complication.
People with type 2 diabetes who can not manage the disease through weight loss, healthy diet and exercise are commonly treated with medications or insulin therapy.
Please make sure you know all the side effects if you are currently taking any form of therapies for diabetic treatment.
Most common symptoms of type 2 diabetes depending on the severity of the stages include increased thirst, frequent urination, unintended weight loss, and fatigue,
In severe cases, patients may also experience symptoms wound that does heal, blurred vision and frequent infections and areas of darkened skin.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding potential ingredients from the treatment of type 2 diabetes, researchers examined the bilberry content of anthocyanins and polyphenols which have been proven to process antidiabetic activity in several studies.
Injection of anthocyanins and polyphenols exhibited an increase in insulin secretion (anthocyanin pelargonidin), reduction of insulin resistance (anthocyanin cyanidin-3-glucoside), and glucose resorption from the GIT (polyphenols) and enhancement of beta-cells regeneration associated with the diabetics.
In the examination of the single ingredient anthocyanins, researchers found the compounds also contribute to the improvement of the lipid spectrum compared to that of acarbose and atorvastatin, according to many preclinical and clinical studies.
Furthermore, the compound derivatives anthocyanin cyanidin-3-galactoside also have antioxidant, anti-inflammatory and cardioprotective activities.
In order to reveal more information about bilberry antidiabetic effects, researchers at the joint study led by the University of Eastern Finland differentiated the serum hippuric acid changes after intake of bilberry.
In a total of 47 individuals with features of the metabolic syndrome, randomly assigned to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12).comapred to from fasting serum samples at baseline and after an 8-week intervention, researchers showed that fasting serum hippuric acid increased significantly (3.5-fold) only in the BB group and correlated with changes in fasting plasma glucose concentration and insulin secretion.
These results suggested bilberry anti-diabetic property not only confirms the Finnish Diabetes Prevention Study but also improves glycemic control and pancreas β-cell function which is reduced in patients with type 2 diabetes.
Dr. the lead scientist wrote after taking into account co and confounders in the final report, "Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the treatment of type 2 diabetes with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes by de Mello VD1, Lankinen MA1, Lindström J2, Puupponen-Pimiä R3, Laaksonen DE4, Pihlajamäki J1,5, Lehtonen M6,7, Uusitupa M1,8, Tuomilehto J2,9,10, Kolehmainen M1, Törrönen R1, Hanhineva K. (PubMed)
(2) [Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitusBillberry (Vaccinium myrtillus)].[Article in Czech] by Koupý D, Kotolová H, Kučerová J. (PubMed)
Betacyanins Inhibits Inflammatory Bowel Disease (IBD) in Vitro
Inflammation is a natural reaction of the immune system against the invasion of the foreign stimuli and pathogens with an aim to protect our body from infection.
In the acute phase of tissue damage or injury, after receiving the information from the neurotransmitters, the white blood cells that response for the first line of defense activate the production of blood platelets and the inflammatory cytokines to the site of infection to destroy the invasive agents.
However, in most cases, overproduction of inflammatory cytokines can damage the nearby cells that lead to improper healing with the formation of scars.
Inflammatory bowel disease (IBD), a class of chronic conditions associated with the inflammation of the digestive tract, can be classified into
* Ulcerative colitis is found in the innermost lining of the colon and rectum.
* Crohn's disease is a type of IBD that causes inflammation of the lining of the digestive tract, other than the colon and rectum.
Epidemiological studies suggested that patients with IBD are associated with the symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss. Long-term persistent symptoms such as weight loss may be life-threatening.
If you have experienced some of the aforementioned symptoms, please make sure to check with your doctor to rule out the possibility.
The causes of IBD are unknown. The alternation of the ratio of gut microbiota may be the major culprit in facilitating the onset of IBD.
Dr. Becker C, the lead scientist wrote, "The intestinal microbiota has important metabolic and host-protective functions. Conversely, to these beneficial functions, the intestinal microbiota is thought to play a central role in the etiopathogenesis of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis), chronic inflammation of the gut mucosa".
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural pigment for the prevention and treatment of colonic inflammation, researchers examined the effects of beetroot (Beta vulgaris var. Rubra) products and their major component betanin found in betacyanins in patients with inflammatory bowel disease (IBD).
According to the tested assays,
* Betanin at the concentration of 100 μM for 24 h increased DNA damage in IBD patients' neutrophils. In other words, betanin exhibited cytotoxic activity against the neutrophils isolated from the blood of patients with inflammatory bowel disease--ulcerative colitis (UC) and Crohn's disease (CD), compared to those obtained in colon carcinoma-derived Caco-2 cells.
* Furthermore, betanin treatment in Caco-2 cells with H2O2 also caused a 4-fold increase of DNA strand breaks compared to untreated cells. More precisely, betanin elevated the expression of free radical H2O2 to cause cancer cell death.
* Moreover, pre-treatment with betanin was found to reduce DNA damage in healthy normal cells.
* Additonally, betanin also promoted the activity of procaspase and caspase pro-apoptotic activity to induce cancer cells apoptosis.
Based on the findings, Dr. the lead scientist said, "These results suggest that betanin may support mechanisms that lead to the release of ROS and apoptotic cell death. In this way, betanin may exert anti-inflammatory and potentially cancer-preventive activity".
Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) The Intestinal Microbiota in Inflammatory Bowel Disease by Becker C1, Neurath MF1, Wirtz S. (PubMed)
In the acute phase of tissue damage or injury, after receiving the information from the neurotransmitters, the white blood cells that response for the first line of defense activate the production of blood platelets and the inflammatory cytokines to the site of infection to destroy the invasive agents.
However, in most cases, overproduction of inflammatory cytokines can damage the nearby cells that lead to improper healing with the formation of scars.
Inflammatory bowel disease (IBD), a class of chronic conditions associated with the inflammation of the digestive tract, can be classified into
* Ulcerative colitis is found in the innermost lining of the colon and rectum.
* Crohn's disease is a type of IBD that causes inflammation of the lining of the digestive tract, other than the colon and rectum.
Epidemiological studies suggested that patients with IBD are associated with the symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss. Long-term persistent symptoms such as weight loss may be life-threatening.
If you have experienced some of the aforementioned symptoms, please make sure to check with your doctor to rule out the possibility.
The causes of IBD are unknown. The alternation of the ratio of gut microbiota may be the major culprit in facilitating the onset of IBD.
Dr. Becker C, the lead scientist wrote, "The intestinal microbiota has important metabolic and host-protective functions. Conversely, to these beneficial functions, the intestinal microbiota is thought to play a central role in the etiopathogenesis of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis), chronic inflammation of the gut mucosa".
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural pigment for the prevention and treatment of colonic inflammation, researchers examined the effects of beetroot (Beta vulgaris var. Rubra) products and their major component betanin found in betacyanins in patients with inflammatory bowel disease (IBD).
According to the tested assays,
* Betanin at the concentration of 100 μM for 24 h increased DNA damage in IBD patients' neutrophils. In other words, betanin exhibited cytotoxic activity against the neutrophils isolated from the blood of patients with inflammatory bowel disease--ulcerative colitis (UC) and Crohn's disease (CD), compared to those obtained in colon carcinoma-derived Caco-2 cells.
* Furthermore, betanin treatment in Caco-2 cells with H2O2 also caused a 4-fold increase of DNA strand breaks compared to untreated cells. More precisely, betanin elevated the expression of free radical H2O2 to cause cancer cell death.
* Moreover, pre-treatment with betanin was found to reduce DNA damage in healthy normal cells.
* Additonally, betanin also promoted the activity of procaspase and caspase pro-apoptotic activity to induce cancer cells apoptosis.
Based on the findings, Dr. the lead scientist said, "These results suggest that betanin may support mechanisms that lead to the release of ROS and apoptotic cell death. In this way, betanin may exert anti-inflammatory and potentially cancer-preventive activity".
Taken altogether, betacyanins processed abundantly bioactive ingredient betanin may be considered a remedy for the prevention and treatment of liver steatosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) The Intestinal Microbiota in Inflammatory Bowel Disease by Becker C1, Neurath MF1, Wirtz S. (PubMed)
Monday, September 16, 2019
Artichoke, the Potential Anti Mesothelioma Remedy, According to Researchers
Mesothelioma is a type of cancer that develops from the thin layer of tissue known as the mesothelium.
Most cases of mesothelioma are found on the lining of the lungs and chest wall, compared to other organs. Pleural mesothelioma is a cancer of the pleural lining of the lung.
Exposure to asbestos which has been banned is one of the most common causes of the disease. Some researchers suggested that inhaling asbestos can cause mesothelioma in many ways, including
* Induced chronic low-grade inflammation of mesothelial cells as the immune system can not completely drive out the fibers that cause damage to the lung, leading to the compromise.
* Long-term exposure of the asbestos can suppress the genes associated with limited cell cycle division and tumor suppression
* Long-term exposure are also found to alter the cell DNA, leading to cancer.
According to statistic, 2000 to 3,000 people are diagnosed with mesothelioma each year in the United States. The asbestos risk of pleural mesothelioma is in the range of 2 to 10 percent.
Most cases of malignant mesothelioma are closely associated with past occupational exposure.
However, asbestos is found persistently in our natural and built environments.
Besides most common cancer symptoms, patients with pleural mesothelioma at the advanced stage may also experience symptoms of dry cough or wheezing, shortness of breath (dyspnea), respiratory complications and pain in the chest or abdomen.
Some patients may also develop pleural effusion (fluid around the lungs), fever or night sweats, fatigue, and muscle weakness
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
In the concern of the malignant pleural mesothelioma, a poorly treated neoplasia by conventional medicine, arising from the pleural mesothelial lining, researchers examined leaf extract of Cynara scolymus in vitro and in vivo.
The study included tMSTO-211H, MPP-89 and NCI-H28 mesothelioma cell lines and untransformed mesothelial cells HMC, treated with increasing concentrations (ranging from 3 to 200 μg/ml) of artichoke leaf extract for 72 hrs.
Injection of the leaf extract not only inhibited strongly the cell proliferation but also affected the migration and tumor engraftment in the mesothelioma cell lines.
More precisely, MSTO-211H cells treated with the artichoke extract showed a change in the cellular morphology both in a short-term assay, compared to more resistant more resistance in the HMC cells.
In MSTO-211H, MPP-89 and NCI-H28 cells, injection of artichoke leaf extract inhibited the formation of cancer cell colony.
Astonishingly, dietary feeding with Cynara scolymus leaf extract showed a similar inhibition against the growth of mesothelioma xenografted tumors comparable to those of pemetrexed.
Where pemetrexed is a chemo medicine used for the treatment of cancer, including mesothelioma.
Dr. Claudio Pulito and colleagues suggested, "leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma".
Taken altogether, artichoke leaf extract may be considered a functioning remedy for the prevention and treatment of mesothelioma, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion by Pulito C1, Mori F1, Sacconi A2, Casadei L3, Ferraiuolo M2, Valerio MC3, Santoro R1, Goeman F2, Maidecchi A4, Mattoli L4, Manetti C3, Di Agostino S2, Muti P5, Blandino G2,5, Strano S. (PMC)
Most cases of mesothelioma are found on the lining of the lungs and chest wall, compared to other organs. Pleural mesothelioma is a cancer of the pleural lining of the lung.
Exposure to asbestos which has been banned is one of the most common causes of the disease. Some researchers suggested that inhaling asbestos can cause mesothelioma in many ways, including
* Induced chronic low-grade inflammation of mesothelial cells as the immune system can not completely drive out the fibers that cause damage to the lung, leading to the compromise.
* Long-term exposure of the asbestos can suppress the genes associated with limited cell cycle division and tumor suppression
* Long-term exposure are also found to alter the cell DNA, leading to cancer.
According to statistic, 2000 to 3,000 people are diagnosed with mesothelioma each year in the United States. The asbestos risk of pleural mesothelioma is in the range of 2 to 10 percent.
Most cases of malignant mesothelioma are closely associated with past occupational exposure.
However, asbestos is found persistently in our natural and built environments.
Besides most common cancer symptoms, patients with pleural mesothelioma at the advanced stage may also experience symptoms of dry cough or wheezing, shortness of breath (dyspnea), respiratory complications and pain in the chest or abdomen.
Some patients may also develop pleural effusion (fluid around the lungs), fever or night sweats, fatigue, and muscle weakness
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
In the concern of the malignant pleural mesothelioma, a poorly treated neoplasia by conventional medicine, arising from the pleural mesothelial lining, researchers examined leaf extract of Cynara scolymus in vitro and in vivo.
The study included tMSTO-211H, MPP-89 and NCI-H28 mesothelioma cell lines and untransformed mesothelial cells HMC, treated with increasing concentrations (ranging from 3 to 200 μg/ml) of artichoke leaf extract for 72 hrs.
Injection of the leaf extract not only inhibited strongly the cell proliferation but also affected the migration and tumor engraftment in the mesothelioma cell lines.
More precisely, MSTO-211H cells treated with the artichoke extract showed a change in the cellular morphology both in a short-term assay, compared to more resistant more resistance in the HMC cells.
In MSTO-211H, MPP-89 and NCI-H28 cells, injection of artichoke leaf extract inhibited the formation of cancer cell colony.
Astonishingly, dietary feeding with Cynara scolymus leaf extract showed a similar inhibition against the growth of mesothelioma xenografted tumors comparable to those of pemetrexed.
Where pemetrexed is a chemo medicine used for the treatment of cancer, including mesothelioma.
Dr. Claudio Pulito and colleagues suggested, "leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma".
Taken altogether, artichoke leaf extract may be considered a functioning remedy for the prevention and treatment of mesothelioma, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion by Pulito C1, Mori F1, Sacconi A2, Casadei L3, Ferraiuolo M2, Valerio MC3, Santoro R1, Goeman F2, Maidecchi A4, Mattoli L4, Manetti C3, Di Agostino S2, Muti P5, Blandino G2,5, Strano S. (PMC)
Green Tea and Its Bioactive Polyphenol in Reduced Risk and Treatment of All Forms of Acne
Green tea may have a therapeutic and positive effect in the prevention and treatment of acne, some scientists suggested.
Green tea is a precious drink with numbers of health benefit known to almost everyone in Asia and the Western world.
Acne is a condition of skin diseases characterized by the occurrence of inflamed or infected sebaceous glands in the skin.
In the examined the effects of EGCG, the bioactive major polyphenol of green tea on human SEB-1 sebocytes with function in secreted sebum in patients with acne, researchers found that EGCG exerted a significant antioxidant activity in reduced sebum secretion by modulating the AMPK -SREBP-1 signaling pathway through AMPK expression in stimulated EGCG effect in regulated the interaction of phosphorylates sterol regulatory element-binding proteins SREBP-1.
Application of green tea EGCG also demonstrated a strong effect in reduced sebum in induction of inflammation of sebaceous glands by suppressing the NF-κB in induced transcription of proinflammatory genes in cellular response to stress and pathogens and AP-1 pathway, a transcription factor with function in regulated gene expression of inflammation factors in response to a variety of stimuli, including bacterial and viral infections.
Furthermore, administration of EGCG also found to have a huge effect in targeting almost all the pathogenic features of acne through exhibited significant cytotoxicity of SEB-1 sebocytes in the induction of viability of P. acnes,
Dr. Yoon JY, the lead author at the Seoul National University Hospital, after taking into account of all findings said, " EGCG significantly improved acne in an 8-week randomized, split-face, clinical trial, and was well tolerated".
Amazingly, the randomized, double-blind, placebo-controlled clinical trial conducted from May 2012 through October 2013. of a total of 64 of 80 women, from 25 to 45 years of age with moderate-to-severe acne randomly assigned to receive either 1500 mg of decaffeinated GTE or placebo (cellulose) daily for 4 weeks indicated that there were statistically significant differences in inflammatory lesion counts found on the nose, and on the chin between the two groups but no significant differences of total lesion counts.
Within-group, green tea application displayed significant reductions in inflammatory lesions distributed on the forehead and cheek with no difference in total lesion counts.
Moreover, the green tea group also resulted in a significant reduction of total cholesterol levels in compared to the cellulose group.
However, due to limitation of the small sample and short time period, researchers postulated that more research is required to determine whether a decaffeinated GTE standardized for EGCG content will provide clinical benefits in women with post-adolescent acne.
Additionally, in selected 59 studies with eight met the inclusion criteria to evaluate the effect of tea polyphenols in reduced sebum production in the skin and for treatment of acne vulgaris by reviewing the literature published on PubMed, researchers suggested that application of tea polyphenols topically may have a beneficial effect in reducing sebum secretion and in treatment of acne through inhibited lipid synthesis by the sebaceous glands.
Truly, according to the University of Miami, in the examine 12 patients with mild-to-moderate acne vulgaris received green tea application twice daily for a period of 6 weeks, topical injection of 2% green tea lotion was found to be effective in treatment with statistically significant in mean total lesion count (TLC) decreased from 24 measured at the baseline to 10 after 6 weeks treatment, a reduction of 58.33%.
The mean severity index (SI) from all patients also decreased from 2.05 before treatment to 1.25 after 6 weeks of treatment, a decrease of 39.02%.
Dr. Elsaie ML, the lead scientists said, "Topical 2% green tea lotion is an effective, cost-effective treatment for mild-to-moderate acne vulgaris".
Taking all together, green tea and its bioactive major polyphenol may be used safely in reduced risk, progression, and treatment of all form of acne pending to a large sample size and multi centers clinical trial. Oral administration of green tea should be taken with exceptional care as some cases of acute liver toxicity were reported.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea and Other Tea Polyphenols: Effects on Sebum Production and Acne Vulgaris by Saric S1, Notay M2, Sivamani RK(PubMed)
(2) Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial by Lu PH1, Hsu CH2.(PubMed)
(3) Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes by Yoon JY1, Kwon HH, Min SU, Thiboutot DM, Suh DH.(PubMed)
(4) The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris by Elsaie ML1, Abdelhamid MF, Elsaaiee LT, Emam HM.(PubMed)
Green tea is a precious drink with numbers of health benefit known to almost everyone in Asia and the Western world.
Acne is a condition of skin diseases characterized by the occurrence of inflamed or infected sebaceous glands in the skin.
In the examined the effects of EGCG, the bioactive major polyphenol of green tea on human SEB-1 sebocytes with function in secreted sebum in patients with acne, researchers found that EGCG exerted a significant antioxidant activity in reduced sebum secretion by modulating the AMPK -SREBP-1 signaling pathway through AMPK expression in stimulated EGCG effect in regulated the interaction of phosphorylates sterol regulatory element-binding proteins SREBP-1.
Application of green tea EGCG also demonstrated a strong effect in reduced sebum in induction of inflammation of sebaceous glands by suppressing the NF-κB in induced transcription of proinflammatory genes in cellular response to stress and pathogens and AP-1 pathway, a transcription factor with function in regulated gene expression of inflammation factors in response to a variety of stimuli, including bacterial and viral infections.
Furthermore, administration of EGCG also found to have a huge effect in targeting almost all the pathogenic features of acne through exhibited significant cytotoxicity of SEB-1 sebocytes in the induction of viability of P. acnes,
Dr. Yoon JY, the lead author at the Seoul National University Hospital, after taking into account of all findings said, " EGCG significantly improved acne in an 8-week randomized, split-face, clinical trial, and was well tolerated".
Amazingly, the randomized, double-blind, placebo-controlled clinical trial conducted from May 2012 through October 2013. of a total of 64 of 80 women, from 25 to 45 years of age with moderate-to-severe acne randomly assigned to receive either 1500 mg of decaffeinated GTE or placebo (cellulose) daily for 4 weeks indicated that there were statistically significant differences in inflammatory lesion counts found on the nose, and on the chin between the two groups but no significant differences of total lesion counts.
Within-group, green tea application displayed significant reductions in inflammatory lesions distributed on the forehead and cheek with no difference in total lesion counts.
Moreover, the green tea group also resulted in a significant reduction of total cholesterol levels in compared to the cellulose group.
However, due to limitation of the small sample and short time period, researchers postulated that more research is required to determine whether a decaffeinated GTE standardized for EGCG content will provide clinical benefits in women with post-adolescent acne.
Additionally, in selected 59 studies with eight met the inclusion criteria to evaluate the effect of tea polyphenols in reduced sebum production in the skin and for treatment of acne vulgaris by reviewing the literature published on PubMed, researchers suggested that application of tea polyphenols topically may have a beneficial effect in reducing sebum secretion and in treatment of acne through inhibited lipid synthesis by the sebaceous glands.
Truly, according to the University of Miami, in the examine 12 patients with mild-to-moderate acne vulgaris received green tea application twice daily for a period of 6 weeks, topical injection of 2% green tea lotion was found to be effective in treatment with statistically significant in mean total lesion count (TLC) decreased from 24 measured at the baseline to 10 after 6 weeks treatment, a reduction of 58.33%.
The mean severity index (SI) from all patients also decreased from 2.05 before treatment to 1.25 after 6 weeks of treatment, a decrease of 39.02%.
Dr. Elsaie ML, the lead scientists said, "Topical 2% green tea lotion is an effective, cost-effective treatment for mild-to-moderate acne vulgaris".
Taking all together, green tea and its bioactive major polyphenol may be used safely in reduced risk, progression, and treatment of all form of acne pending to a large sample size and multi centers clinical trial. Oral administration of green tea should be taken with exceptional care as some cases of acute liver toxicity were reported.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea and Other Tea Polyphenols: Effects on Sebum Production and Acne Vulgaris by Saric S1, Notay M2, Sivamani RK(PubMed)
(2) Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial by Lu PH1, Hsu CH2.(PubMed)
(3) Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes by Yoon JY1, Kwon HH, Min SU, Thiboutot DM, Suh DH.(PubMed)
(4) The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris by Elsaie ML1, Abdelhamid MF, Elsaaiee LT, Emam HM.(PubMed)
Sunday, September 15, 2019
Phytochemical Alliin Balances the Ratio of Free Radicals and Antioxidants Levels
Oxidative stress is a medical condition caused by a long-term imbalance of the ratio of free radicals and antioxidants in the body.
In other words, overexpression of free radicals and depletion of antioxidant enzymes produced by the host body are the most common cause of oxidative stress.
Oxidative stress occurs when the abundant and unstable free radicals start a chain reaction by stealing or donating their unpaired electrons in the outermost ring to stable atoms, leading to a cascade that cannot be stopped until all electrons are paired or inhibited by antioxidant.
Oxidative stress is dealy to oxidized protein, lipid and cause cell damage that have been linking to chronic diseases such as cardiovascular disease, diabetes, and cancer.
Certain risk factors such as unhealthy lifestyle such as smoking, an unhealthy diet with fewer fruits and vegetables, certain medical conditions such as chronic inflammatory disease and environmental factors such as pollution and radiation have linked to the onset of oxidative stress.
Believe it or not, people with a weakened immune system are more prone to oxidative stress compared to a healthy individual. Therefore, intake of antioxidants from the dietary sources may be necessary.
Dr. JA Knight in the investigation of free radicals, antioxidants, and immune system wrote, " oxidative stress may be detrimental in acquired immunity by activation of nuclear factor kappa B, which governs gene expression involving various cytokines, chemokines, and cell adhesion molecules, among others"
And "antioxidant supplementation essentially reverses several age-associated immune deficiencies, resulting in increased levels of interleukin-2, elevated numbers of total lymphocytes and T-cell subsets, enhanced mitogen responsiveness, increased killer cell activity, augmented antibody response to antigen stimulation, decreased lipid peroxidation, and decreased prostaglandin synthesis".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, scientists investigated the effects of garlic active compounds, diallyl disulfide (DADS), diallyl sulfide (DAS) and alliin against Dengue virus (DENV).
Based on the tested assays, alliin reduced inflammation and affected the oxidative stress response by blocking the immune system response involved in the production of pro-inflammatory cytokines against the oxidative stress.
Furthermore, in cancer cells, pretreatment of alliin exerted a toxic effect on several mammalian cells in vitro in a dose-dependent manner.
In other words, alliin demonstrated significant cytotoxicity against cancer cells by killing them before they can reproduce.
More precisely, alliin-induced cancer cell apoptosis by increasing caspase-3 expression, DNA fragmentation, cell cycle arrest, ROS generation, GSH depletion.
The findings suggested that alliin modulated oxidative stress (the production of antioxidant and free radicals) depending on the body needs without causing harm to the healthy cells.
Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression by Chhabria SV1, Akbarsha MA, Li AP, Kharkar PS, Desai KB. (PubMed)
(2) Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stressduring Dengue Virus Infection by Hall A1, Troupin A2, Londono-Renteria B3, Colpitts TM4. (PubMed)
(3) Review: Free radicals, antioxidants, and the immune system by JA Knight. (Annual of Clinical & Laboratory Science)
In other words, overexpression of free radicals and depletion of antioxidant enzymes produced by the host body are the most common cause of oxidative stress.
Oxidative stress occurs when the abundant and unstable free radicals start a chain reaction by stealing or donating their unpaired electrons in the outermost ring to stable atoms, leading to a cascade that cannot be stopped until all electrons are paired or inhibited by antioxidant.
Oxidative stress is dealy to oxidized protein, lipid and cause cell damage that have been linking to chronic diseases such as cardiovascular disease, diabetes, and cancer.
Certain risk factors such as unhealthy lifestyle such as smoking, an unhealthy diet with fewer fruits and vegetables, certain medical conditions such as chronic inflammatory disease and environmental factors such as pollution and radiation have linked to the onset of oxidative stress.
Believe it or not, people with a weakened immune system are more prone to oxidative stress compared to a healthy individual. Therefore, intake of antioxidants from the dietary sources may be necessary.
Dr. JA Knight in the investigation of free radicals, antioxidants, and immune system wrote, " oxidative stress may be detrimental in acquired immunity by activation of nuclear factor kappa B, which governs gene expression involving various cytokines, chemokines, and cell adhesion molecules, among others"
And "antioxidant supplementation essentially reverses several age-associated immune deficiencies, resulting in increased levels of interleukin-2, elevated numbers of total lymphocytes and T-cell subsets, enhanced mitogen responsiveness, increased killer cell activity, augmented antibody response to antigen stimulation, decreased lipid peroxidation, and decreased prostaglandin synthesis".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, scientists investigated the effects of garlic active compounds, diallyl disulfide (DADS), diallyl sulfide (DAS) and alliin against Dengue virus (DENV).
Based on the tested assays, alliin reduced inflammation and affected the oxidative stress response by blocking the immune system response involved in the production of pro-inflammatory cytokines against the oxidative stress.
Furthermore, in cancer cells, pretreatment of alliin exerted a toxic effect on several mammalian cells in vitro in a dose-dependent manner.
In other words, alliin demonstrated significant cytotoxicity against cancer cells by killing them before they can reproduce.
More precisely, alliin-induced cancer cell apoptosis by increasing caspase-3 expression, DNA fragmentation, cell cycle arrest, ROS generation, GSH depletion.
The findings suggested that alliin modulated oxidative stress (the production of antioxidant and free radicals) depending on the body needs without causing harm to the healthy cells.
Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression by Chhabria SV1, Akbarsha MA, Li AP, Kharkar PS, Desai KB. (PubMed)
(2) Garlic Organosulfur Compounds Reduce Inflammation and Oxidative Stressduring Dengue Virus Infection by Hall A1, Troupin A2, Londono-Renteria B3, Colpitts TM4. (PubMed)
(3) Review: Free radicals, antioxidants, and the immune system by JA Knight. (Annual of Clinical & Laboratory Science)
Herbal Ginger, the Best Chemo Preventive Functional Food
Scientists may have found a natural ingredient which processed chemopreventive effects, with no side effects, according to study.
Chemoprevention is a general term used to describe the use of nontoxic natural chemicals and supplements for the treatment of cancer without inducing side effects.
The subjects of chemoprevention have under intensive studies over the last many years due to the side effects of chemo drugs. Natural chemopreventive agents have emerged as a promising and pragmatic medical approach to reduce the risk of cancer.
Most natural chemical compounds have been found to process the activity similar to those of conventional medicines for the treatment of cancer such as antioxidative, anti-inflammatory activity, induction of phase II enzymes, apoptosis, and cell cycle arrest.
For example: Curcumin found in turmeric in animal models has been shown to protect against skin, oral, intestinal, and colon carcinogenesis and also to suppress angiogenesis and metastasis.
Furthermore, the administration also found that the chemical compound process the ability to cancer proliferation by cell cycle arrest, induced apoptosis and activated the phase carcinogen-detoxifying enzymes.
Moreover, curcumin has a capability to inhibit carcinogen bioactivation via suppression of specific cytochrome P450 isozymes associated with the biotransformation of medication that causes drug toxicities, reduced pharmacological effect, and adverse drug reactions.
Dr. Pan MH the lead scientist in the cancer team at the National Kaohsiung Marine University wrote, "Many mechanisms have been shown to account for the anticarcinogenic actions of natural dietary compounds; attention has recently been focused on intracellular-signaling cascades as common molecular targets for various chemopreventive natural dietary compounds".
And, "In this critical review, we will summarize current knowledge on natural dietary compounds that act through the signaling pathways and modulate gene expression to induce detoxifying enzymes, programmed cell death, anti-inflammatory, and anti-proliferative effects, thus providing evidence for these substances in cancer chemopreventive action".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural ingredient which processes chemopreventive effects with no side effects, researchers examined the ginger effect on cancer prevention.
Ginger exerted a significant activity against cancer onset through several mechanisms, including free radical scavenging, antioxidant pathways, alteration of gene expressions, and induction of apoptosis.
Ginger protects the integrity and viability of the cell by decreasing tumor initiation, promotion, and progression.
Dr. Baliga MS, the lead scientist,. after taking other factors into accounts wrote, "The above-mentioned mechanisms of ginger seem to be promising for cancer prevention; however, further clinical studies are warranted to assess the efficacy and safety of ginger".
In order to reveal more information about the ginger anticancer activity, researchers evaluated the effects of [6]-gingerol aspirinate (GAS) against colorectal cancers.
GAS exerts enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice by inhibiting the protein associated with the production of proinflammatory cytokines.
More importantly, GAS was also able to survive stomach acid and decomposed in intestinal linings or after absorption to simultaneously release of [6]-gingerol.
Dr. Zhu Y, the lead researcher said, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".
Take all together, ginger processed high amounts of the bioactive compound may be considered a functional alternative for chemoprevention, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Update on the chemopreventive effects of ginger and its phytochemicals by Baliga MS1, Haniadka R, Pereira MM, D'Souza JJ, Pallaty PL, Bhat HP, Popuri S. (PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Zhu Y1, Wang F1,2, Zhao Y1, Wang P1, Sang S. (PubMed)
(3) Chemopreventive effects of natural dietary compounds on cancer development by Pan MH1, Ho CT. (PubMed)
(4) Cancer chemopreventive effects of curcumin by Surh YJ1, Chun KS. (PubMed)
Chemoprevention is a general term used to describe the use of nontoxic natural chemicals and supplements for the treatment of cancer without inducing side effects.
The subjects of chemoprevention have under intensive studies over the last many years due to the side effects of chemo drugs. Natural chemopreventive agents have emerged as a promising and pragmatic medical approach to reduce the risk of cancer.
Most natural chemical compounds have been found to process the activity similar to those of conventional medicines for the treatment of cancer such as antioxidative, anti-inflammatory activity, induction of phase II enzymes, apoptosis, and cell cycle arrest.
For example: Curcumin found in turmeric in animal models has been shown to protect against skin, oral, intestinal, and colon carcinogenesis and also to suppress angiogenesis and metastasis.
Furthermore, the administration also found that the chemical compound process the ability to cancer proliferation by cell cycle arrest, induced apoptosis and activated the phase carcinogen-detoxifying enzymes.
Moreover, curcumin has a capability to inhibit carcinogen bioactivation via suppression of specific cytochrome P450 isozymes associated with the biotransformation of medication that causes drug toxicities, reduced pharmacological effect, and adverse drug reactions.
Dr. Pan MH the lead scientist in the cancer team at the National Kaohsiung Marine University wrote, "Many mechanisms have been shown to account for the anticarcinogenic actions of natural dietary compounds; attention has recently been focused on intracellular-signaling cascades as common molecular targets for various chemopreventive natural dietary compounds".
And, "In this critical review, we will summarize current knowledge on natural dietary compounds that act through the signaling pathways and modulate gene expression to induce detoxifying enzymes, programmed cell death, anti-inflammatory, and anti-proliferative effects, thus providing evidence for these substances in cancer chemopreventive action".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural ingredient which processes chemopreventive effects with no side effects, researchers examined the ginger effect on cancer prevention.
Ginger exerted a significant activity against cancer onset through several mechanisms, including free radical scavenging, antioxidant pathways, alteration of gene expressions, and induction of apoptosis.
Ginger protects the integrity and viability of the cell by decreasing tumor initiation, promotion, and progression.
Dr. Baliga MS, the lead scientist,. after taking other factors into accounts wrote, "The above-mentioned mechanisms of ginger seem to be promising for cancer prevention; however, further clinical studies are warranted to assess the efficacy and safety of ginger".
In order to reveal more information about the ginger anticancer activity, researchers evaluated the effects of [6]-gingerol aspirinate (GAS) against colorectal cancers.
GAS exerts enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice by inhibiting the protein associated with the production of proinflammatory cytokines.
More importantly, GAS was also able to survive stomach acid and decomposed in intestinal linings or after absorption to simultaneously release of [6]-gingerol.
Dr. Zhu Y, the lead researcher said, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".
Take all together, ginger processed high amounts of the bioactive compound may be considered a functional alternative for chemoprevention, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Update on the chemopreventive effects of ginger and its phytochemicals by Baliga MS1, Haniadka R, Pereira MM, D'Souza JJ, Pallaty PL, Bhat HP, Popuri S. (PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Zhu Y1, Wang F1,2, Zhao Y1, Wang P1, Sang S. (PubMed)
(3) Chemopreventive effects of natural dietary compounds on cancer development by Pan MH1, Ho CT. (PubMed)
(4) Cancer chemopreventive effects of curcumin by Surh YJ1, Chun KS. (PubMed)
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