Green tea may have a therapeutic and positive effect in reduced risk and and treatment of cold sore (herpes simplex labialis infection), some scientists suggested.
Cold sore is a common skin disease characterized by tiny blisters that develop on the lips or around the mouth caused by the infection of herpes simplex virus strain HSV-1 mostly.
Believe it or not, over 80% of the North American population have herpes 1 virus living permanently in their body without causing any health problem. However, the dormant virus can quickly multiple to affect the skin on the lips if the immune system is weakened or triggered by certain conditions such as prolonged stress, a digestive disorder.
The virus is very contagious, anyone who comes to direct contact with an infected person can easily be infected.
Most common symptoms of cold sore include sensations, tingling,,...... pain, or numbness on the lip and skin surround the lip.
Cold sore that appears inside the mouth may be troublesome, as the condition interferes with food injection and speech.
In a number of severe cases, herpes 1 virus may infect the eye, brain, leading to vision loss and certain brain infectious diseases.
Conventional antiviral medicine used for the treatment of cold sore may be effective such as Zovirax, Famvir,..... and valacyclovir, but they can induce certain side effects including digestive discomforts,..., headache, dizziness,.... and tiredness.
In the reaffirmed the efficacy of catechins from the tea plant (Camellia sinensis) therapeutic effect on herpes simplex virus infections in vitro and in vivo, researchers conducted a double-blind, placebo-controlled, randomized trial with 40 participants.
The aim of the joint study is to clinically evaluate a topical proprietary formulation containing lipophilic catechins (AverTeaX, Camellix, LLC, Evans, GA, USA) on recurrent herpes labialis.
In compared to vehicle group treated with 100% glycerin USP, CVS Pharmacies, Inc., Woonsocket, RI, USA), topical application of AverTeaX applied six to eight times daily showed a strong reduction in clinical episode duration (median 4.5 days vs. 9 days) and shortened blistering and ulceration stages within an episode from a median of 3 days to 1 day.
According to the median quality-of-life scores, AverTeaX treated group demonstrated in respect to duration of itching, from a median of 4 days to 1 day, and duration until symptom-free, from a median of 8 days to 4 days.
Interestingly, both groups displayed similar in median scores for itching, pain, burning, swelling, bleeding, and stress.
No adverse effects were found in both groups, during the term of study.
Based on these results, Dr. Zhao M, after taking into account of other co-founders, said, "AverTeaX formulation containing lipophilic catechins effectively inhibited herpes simplex labialis infection with clinical significance".
Additionally, in further analysis to address the green tea extract in reduced expression of HSV in precipitated risk of skin infection, including cold sore and reconfirmed EGCG anti-oxidant activity in inhibited number of plaques in HIV-infected cultured cells, a study to evaluate the efficacy of modified EGCG palmitoyl-EGCG (p-EGCG), as a topical antiviral agent for Herpes Simplex Virus (HSV-1) infections was conducted.
p-EGCG is not toxic to cultured Vero cells, according to the cell viability and cell proliferation assays
According to the results, the application of p-EGCG increased the effectiveness of EGCG as an antiviral agent.
In compared to EGCG topically applied to the skin, one of the primary tissues infected by HSV, green tea polyphenol epigallocatechin gallate (EGCG) with palmitate was a more potent inhibitor of Herpes Simplex Virus 1 (HSV-1).
Observation of other assays used in the experiment, p-EGCG concentrations of 50 µM or higher exerted linearly in blocking the production of infectious HSV-1 particles.
This efficacy suggested that p-EGCG may be considered as a potent and natural ingredient in inhibited HSV-1 adsorption to Vero cells.
Thus, p-EGCG may provide a novel treatment for HSV-1 infections, including cold sore.
The findings suggested that topically green tea used a combination of other herbal ingredients or green tea extract used alone may have a therapeutic potential in the treatment of cold sore caused by herpes simplex virus HSV-1 infection)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula by Zhao M1, Zheng R1, Jiang J1, Dickinson D2, Fu B1, Chu TC3, Lee LH4, Pearl H5, Hsu S6.(PubMed)
(2) Inhibition of Herpes Simplex Virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate by Aline de Oliveira,a Sandra D. Adams,b Lee H. Lee,b Sean R. Murray,c Stephen D. Hsu,d Jeffrey R. Hammond,cDouglas Dickinson,d Ping Chen,e and Tin-Chun Chua(PMC)
Thursday, October 10, 2019
Wednesday, October 9, 2019
Cooked Tomato's Lycopene Protects Protein, Lipid and Cell Damage Against Oxidative Stress in Human Studies
Oxidative stress is a condition characterized by overexpression of free radicals in the body.
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.
Free radical is an unstable atom with a single electron on the outermost ring. Given to its nature, free radical readily donate or intercept an electron from another atom, leading a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.
The antioxidant is a stable atom with a function to inhibit oxidation, come either from dietary sources or produced by the body.
Contrast to general belief, free radical is also needed in moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.
According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.
However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.
Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, pollution are some of the risk factors associated with the increased risk of oxidative stress.
Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributed to aging in humans.
Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.
In a total of 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael 's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin and glutathione peroxidase (GPx).
Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.
In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.
After a month, the participants were randomly divided into groups with 15 members each consumed either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.
According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.
Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation were found to increase substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.
Taken altogether, tomatoes and its major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.
Free radical is an unstable atom with a single electron on the outermost ring. Given to its nature, free radical readily donate or intercept an electron from another atom, leading a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.
The antioxidant is a stable atom with a function to inhibit oxidation, come either from dietary sources or produced by the body.
Contrast to general belief, free radical is also needed in moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.
According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.
However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.
Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, pollution are some of the risk factors associated with the increased risk of oxidative stress.
Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributed to aging in humans.
Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.
In a total of 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael 's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin and glutathione peroxidase (GPx).
Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.
In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.
After a month, the participants were randomly divided into groups with 15 members each consumed either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.
According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.
Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation were found to increase substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.
Taken altogether, tomatoes and its major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)
Green tea and Its Polyphenols for Prevention and Treatment of Colitis
Green tea may have a therapeutic and profound effect on reduced risk and treatment of colitis, some scientists suggested.
Green tea, a precious drink processes a numbers of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Colitis is a medical condition characterized by inflammation of the inner lining of the colon as a result of infection, inflammation caused by other bowel diseases.
In the comparison of the effects of green tea extract epigallocatechin-3-gallate, EGCG and
Piper nigrum (L.) alkaloid piperine in mice colitis induced by oral administration of dextran sodium sulfate randomly assigned to a daily oral administration of 6.9 mg/kg body weight EGCG or Piper nigrum (L.) piperine (2.9 mg/kg body weight) or the combination of the both with piperine used in the combination to enhance the bioavailability of EGCG and untreated controls, researchers at the Münster University Hospital showed that mice group treated with the combination demonstrated a significant effect in reduced weight loss and improved overall survival in compared to non treatment group through inducing lesser histological damages to the colon and reduction of tissue concentrations of malondialdehyde, an indication of decreased oxidative stress.
According to neutrophils accumulation assay, the application of green tea EGCG and piperine displayed a strong activity in reduced ROS expression in the induction of lipid peroxidation through activation of overexpression of antioxidant enzymes such as superoxide dismutase(SOD) and glutathione peroxidase(GPO).
Further examining also found that the combined ingredients induced an also reduced the production of proinflammatory cytokines.
Dr. Brückner M, after taking into account of other con-founders suggested, "the concept of anti-inflammatory properties of EGCG being generally beneficial in the DSS-model of colitis".
Interestingly, in dextran sulfate sodium (DSS)-induced mouse model of colitis, application of green tea EGCG (3.2 mg/g) as a source of drinking fluid for 3 days exerted a significant effect in ameliorated of colon shortening and spleen enlargement caused by injection of DSS and modulated the production of levels inflammatory cytokines of of interleukin 1 beta (IL-1β) and
Interleukin 6 (IL-6), which plays an important role in the regulation of immune and inflammatory responses to acute and chronic infections.
Furthermore, green tea oral administration also decreased levels of tumor necrosis factor-α, a cell-signaling protein in activated systemic inflammation and pro-inflammatory cytokines in the acute phase of reaction and inhibited ROS expression colonic lipid peroxides through antioxidant activity.
Moreover, the bioactive polyphenol EGCG also improved the small intestinal function in reduced leaky gut, associated with the risk of increasing the number of harmful compounds entering the bloodstream.
Further analysis of green tea efficacy in the treatment of colitis, researchers discovered that green tea EGCG also induced weight loss through the binding on the surface of the small intestine in decreased protein and lipid digestion.
In additional evaluation of green tea polyphenols (GrTP, EGCG) and sulfasalazine activity in colitis induced by injection of Dextran sodium sulfate (DSS) to cause deficiency of IL-10 in BALB/c mice, researchers at the University of Kentucky, postulated that the combined administration significantly ameliorates colonic damage and histological scores in a similar manner (GrTP vs. DSS p < 0.05; EGCG, sulfasalazine vs. DSS p < 0.01) and decrease expression of the inflammatory markers TNFα (3-fold), IL-6 (14-fold) as mentioned above.
Importantly, treated mice with both green tea polyphenols (GrTP, EGCG) and sulfasalazine also expressed a huge improvement in antioxidant capacity in inhibition of ROS in an initiated chain reaction to facilitate of plagues formation and inflammation, observed by the activity of bio maker lectin levels.
The information findings insisted that green tea with abundantly selective bioactive polyphenols may be considered as a functional food for the prevention and treatment of colitis. However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity was reported in numbers of cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis by Brückner M1, Westphal S, Domschke W, Kucharzik T, Lügering A.(PubMed)
(2) (-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss by Bitzer ZT1, Elias RJ1, Vijay-Kumar M2, Lambert JD3,4.(PubMed)
(3) Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in ColitisModels by Oz HS1, Chen T, de Villiers WJ.(PubMed)
Green tea, a precious drink processes a numbers of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Colitis is a medical condition characterized by inflammation of the inner lining of the colon as a result of infection, inflammation caused by other bowel diseases.
In the comparison of the effects of green tea extract epigallocatechin-3-gallate, EGCG and
Piper nigrum (L.) alkaloid piperine in mice colitis induced by oral administration of dextran sodium sulfate randomly assigned to a daily oral administration of 6.9 mg/kg body weight EGCG or Piper nigrum (L.) piperine (2.9 mg/kg body weight) or the combination of the both with piperine used in the combination to enhance the bioavailability of EGCG and untreated controls, researchers at the Münster University Hospital showed that mice group treated with the combination demonstrated a significant effect in reduced weight loss and improved overall survival in compared to non treatment group through inducing lesser histological damages to the colon and reduction of tissue concentrations of malondialdehyde, an indication of decreased oxidative stress.
According to neutrophils accumulation assay, the application of green tea EGCG and piperine displayed a strong activity in reduced ROS expression in the induction of lipid peroxidation through activation of overexpression of antioxidant enzymes such as superoxide dismutase(SOD) and glutathione peroxidase(GPO).
Further examining also found that the combined ingredients induced an also reduced the production of proinflammatory cytokines.
Dr. Brückner M, after taking into account of other con-founders suggested, "the concept of anti-inflammatory properties of EGCG being generally beneficial in the DSS-model of colitis".
Interestingly, in dextran sulfate sodium (DSS)-induced mouse model of colitis, application of green tea EGCG (3.2 mg/g) as a source of drinking fluid for 3 days exerted a significant effect in ameliorated of colon shortening and spleen enlargement caused by injection of DSS and modulated the production of levels inflammatory cytokines of of interleukin 1 beta (IL-1β) and
Interleukin 6 (IL-6), which plays an important role in the regulation of immune and inflammatory responses to acute and chronic infections.
Furthermore, green tea oral administration also decreased levels of tumor necrosis factor-α, a cell-signaling protein in activated systemic inflammation and pro-inflammatory cytokines in the acute phase of reaction and inhibited ROS expression colonic lipid peroxides through antioxidant activity.
Moreover, the bioactive polyphenol EGCG also improved the small intestinal function in reduced leaky gut, associated with the risk of increasing the number of harmful compounds entering the bloodstream.
Further analysis of green tea efficacy in the treatment of colitis, researchers discovered that green tea EGCG also induced weight loss through the binding on the surface of the small intestine in decreased protein and lipid digestion.
In additional evaluation of green tea polyphenols (GrTP, EGCG) and sulfasalazine activity in colitis induced by injection of Dextran sodium sulfate (DSS) to cause deficiency of IL-10 in BALB/c mice, researchers at the University of Kentucky, postulated that the combined administration significantly ameliorates colonic damage and histological scores in a similar manner (GrTP vs. DSS p < 0.05; EGCG, sulfasalazine vs. DSS p < 0.01) and decrease expression of the inflammatory markers TNFα (3-fold), IL-6 (14-fold) as mentioned above.
Importantly, treated mice with both green tea polyphenols (GrTP, EGCG) and sulfasalazine also expressed a huge improvement in antioxidant capacity in inhibition of ROS in an initiated chain reaction to facilitate of plagues formation and inflammation, observed by the activity of bio maker lectin levels.
The information findings insisted that green tea with abundantly selective bioactive polyphenols may be considered as a functional food for the prevention and treatment of colitis. However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity was reported in numbers of cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis by Brückner M1, Westphal S, Domschke W, Kucharzik T, Lügering A.(PubMed)
(2) (-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss by Bitzer ZT1, Elias RJ1, Vijay-Kumar M2, Lambert JD3,4.(PubMed)
(3) Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in ColitisModels by Oz HS1, Chen T, de Villiers WJ.(PubMed)
Tuesday, October 8, 2019
How to Prevent Over Expression of Melanin in Induction of Age Spots Naturally, US National Library of Medicine Studies Reveal
Green tea may have a therapeutic and positive effect in reduced age spots caused by overexpression of melanin, some scientists suggested.
People with a light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.
The results of this investigation were carried out by some worldwide institutes, including the Chongqing Institute of Forensic Science.
You can view the publication through some online medical literature if you want to know more about these subjects.
An age spot is the overexpression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,...
Age spots may also be caused by a hormone imbalance in the induction of increased production of melanin, which is responsible for darkening the skin.
Green tea is a precious drink processed number of health benefits and known to almost everyone in Asia and the Western world.
In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that application EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.
Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of the natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.
HA synthase enzymes (HAS) a molecule with the function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environmental stress exposure.
Hyaluronidase ((HYAL) is an enzyme that cleaves HA.
In UVB irradiation conditions, the application of EGCG protected the expression of decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cell's information of free radicals and decreased in cell viability.
Melanin produced in melanocytes, underexposure UVB irradiation with an aim to protect skin cells against UVB radiation damage.
Years of frequent and prolonged sun exposure and overexpression of melanin may induce aging spot
In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of the aging spots due to exposure UVB irradiation
HaCaT widely used in scientific research of epidermis is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.
Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".
Furthermore, in confirmation of green tea efficacy in reduced overexpression of skin pigment by evaluating the fatty acids contents in the green tea oil, researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.
A single application of each fatty acid demonstrated strong protection of the cell viabilities through their antioxidant activity.
Moreover, the antioxidant activity of 3% tea seed oil exerted greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.
Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.
Taking all together, green tea and its bioactive compound such as EGCG may be used as a natural and functional food for reduced overexpression of melanin and skin pigment in the induction of age spots.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1.(PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)
People with a light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.
The results of this investigation were carried out by some worldwide institutes, including the Chongqing Institute of Forensic Science.
You can view the publication through some online medical literature if you want to know more about these subjects.
An age spot is the overexpression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,...
Age spots may also be caused by a hormone imbalance in the induction of increased production of melanin, which is responsible for darkening the skin.
Green tea is a precious drink processed number of health benefits and known to almost everyone in Asia and the Western world.
In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that application EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.
Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of the natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.
HA synthase enzymes (HAS) a molecule with the function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environmental stress exposure.
Hyaluronidase ((HYAL) is an enzyme that cleaves HA.
In UVB irradiation conditions, the application of EGCG protected the expression of decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cell's information of free radicals and decreased in cell viability.
Melanin produced in melanocytes, underexposure UVB irradiation with an aim to protect skin cells against UVB radiation damage.
Years of frequent and prolonged sun exposure and overexpression of melanin may induce aging spot
In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of the aging spots due to exposure UVB irradiation
HaCaT widely used in scientific research of epidermis is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.
Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".
Furthermore, in confirmation of green tea efficacy in reduced overexpression of skin pigment by evaluating the fatty acids contents in the green tea oil, researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.
A single application of each fatty acid demonstrated strong protection of the cell viabilities through their antioxidant activity.
Moreover, the antioxidant activity of 3% tea seed oil exerted greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.
Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.
Taking all together, green tea and its bioactive compound such as EGCG may be used as a natural and functional food for reduced overexpression of melanin and skin pigment in the induction of age spots.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1.(PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)
Navy Bean Promotes the Gut Health
The colon formed part of the digestive system is also called the large intestine which plays a critical role in removing water, salt, and forming a stool through its muscles lines.
There are over 100 trillion live in the colon that maintains a healthy balance with the body.
In a normal or healthy individual, gut microbiota besides protecting the host against pathogens that cause infectious disease, it also has strong imparts in some specific function in the host, including
* Nutrient metabolism is a process that absorbs end products of food digestion such as monosaccharides, glucose from carbohydrates, monoacylglycerol and long-chain fatty acids from lipids, and small peptides and amino acids from protein.
* Xenobiotic metabolism is the action that protects the host against chemicals that affect normal metabolism.
* Drug metabolism is the process to alter chemical of a drug that may cause harm to the body
* Gut microbiota also has been found to protect gut mucosal barrier in preserving the ability to absorb nutrients.
* Gut microbiota immunomodulatory activity reduced the risk of disease associated with chronic inflammation of the digestive tract, such as bowel inflammatory disease.
However, there are several factors that may have strong impacts on gut microbiota. Dr. Sai Manasa Jandhyala, the lead scientist wrote, " (1) the mode of delivery (vaginal or cesarean); (2) diet during infancy (breast milk or formula feeds) and adulthood (vegan-based or meat-based); and (3) use of antibiotics or antibiotic like molecules that are derived from the environment of the gut commensal community.
And "A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in the reservoir of organisms with a multidrug-resistant gene pool".
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
On finding a natural compound for the improvement of colon health, researchers examined the effect of cooked navy bean (NB) or black bean (BB) flours on the colonic microenvironment in the gut.
The study included C57Bl/6 mice were fed diets supplemented with 20% cooked navy bean (NB) or black bean (BB) flours or an isocaloric basal diet control (BD) for 3 weeks.
According to the tested analysis* Both NB and BB similarly altered the fecal microbiota community structure by increasing the abundance of carbohydrate fermenting bacteria such as Prevotella, S24-7, and Ruminococcus flavefaciens.
* Both beans also enhanced short-chain fatty acid (SCFA) production (microbial-derived carbohydrate fermentation products) by activating the colonic expression of the SCFA receptors GPR-41/-43/-109a associated with reduced colonic inflammation.
* Furthermore, parameters associated with the improvement of the colon health were also enhanced by the administration of black and navy beans, including the biomarkers of colon barrier integrity such as crypt height, mucus content, cell proliferation, and goblet cell number.
The results strongly suggested that the navy bean improves colon health by increasing the expression of gut "good" microorganisms.
Based on the findings, researchers said, " Overall, NB and BB improved baseline colonic microenvironment function by altering the microbial community structure and activity and promoting colon barrier integrity and function; effects which may prove beneficial in attenuating gut-associated diseases".
Taken altogether, the cooked navy bean may be considered a remedy for the improvement of the colon health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(2) White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate by Monk JM1, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Liu R2, Pauls KP3, Wood GA4, Tsao R2, Robinson LE5, Power KA. (PubMed)
(3) Role of the normal gut microbiota by Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, and D Nageshwar Reddy. (PMC)
There are over 100 trillion live in the colon that maintains a healthy balance with the body.
In a normal or healthy individual, gut microbiota besides protecting the host against pathogens that cause infectious disease, it also has strong imparts in some specific function in the host, including
* Nutrient metabolism is a process that absorbs end products of food digestion such as monosaccharides, glucose from carbohydrates, monoacylglycerol and long-chain fatty acids from lipids, and small peptides and amino acids from protein.
* Xenobiotic metabolism is the action that protects the host against chemicals that affect normal metabolism.
* Drug metabolism is the process to alter chemical of a drug that may cause harm to the body
* Gut microbiota also has been found to protect gut mucosal barrier in preserving the ability to absorb nutrients.
* Gut microbiota immunomodulatory activity reduced the risk of disease associated with chronic inflammation of the digestive tract, such as bowel inflammatory disease.
However, there are several factors that may have strong impacts on gut microbiota. Dr. Sai Manasa Jandhyala, the lead scientist wrote, " (1) the mode of delivery (vaginal or cesarean); (2) diet during infancy (breast milk or formula feeds) and adulthood (vegan-based or meat-based); and (3) use of antibiotics or antibiotic like molecules that are derived from the environment of the gut commensal community.
And "A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in the reservoir of organisms with a multidrug-resistant gene pool".
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
On finding a natural compound for the improvement of colon health, researchers examined the effect of cooked navy bean (NB) or black bean (BB) flours on the colonic microenvironment in the gut.
The study included C57Bl/6 mice were fed diets supplemented with 20% cooked navy bean (NB) or black bean (BB) flours or an isocaloric basal diet control (BD) for 3 weeks.
According to the tested analysis* Both NB and BB similarly altered the fecal microbiota community structure by increasing the abundance of carbohydrate fermenting bacteria such as Prevotella, S24-7, and Ruminococcus flavefaciens.
* Both beans also enhanced short-chain fatty acid (SCFA) production (microbial-derived carbohydrate fermentation products) by activating the colonic expression of the SCFA receptors GPR-41/-43/-109a associated with reduced colonic inflammation.
* Furthermore, parameters associated with the improvement of the colon health were also enhanced by the administration of black and navy beans, including the biomarkers of colon barrier integrity such as crypt height, mucus content, cell proliferation, and goblet cell number.
The results strongly suggested that the navy bean improves colon health by increasing the expression of gut "good" microorganisms.
Based on the findings, researchers said, " Overall, NB and BB improved baseline colonic microenvironment function by altering the microbial community structure and activity and promoting colon barrier integrity and function; effects which may prove beneficial in attenuating gut-associated diseases".
Taken altogether, the cooked navy bean may be considered a remedy for the improvement of the colon health, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(2) White and dark kidney beans reduce colonic mucosal damage and inflammation in response to dextran sodium sulfate by Monk JM1, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Liu R2, Pauls KP3, Wood GA4, Tsao R2, Robinson LE5, Power KA. (PubMed)
(3) Role of the normal gut microbiota by Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, and D Nageshwar Reddy. (PMC)
Monday, October 7, 2019
Carotenoids Block the Onset of Colorectal Cancer in Patients with DICER1 rs3742330 Genotypeancer
Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.
The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colorectal cancer is cancer located in the colon or rectum caused alternation of cell DNA. Most cases of colorectal cancer begin in the cells on the surface of inner ling tissue in either the colon or rectum, before multiplying to form a tumor.
Colorectal cancer is relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the statistics provided by the American Cancer Society, in the US,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in 2019.
Additionally, colorectal cancer will also cause the death of 51,020 Americans in 2019.
Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.
Besides adenocarcinomas, the common type of colorectal cancer originated in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, other types of colorectal tumors include
* Carcinoid
Carcinoid is an unusual type of slow growth neuroendocrine tumor in the hormone-producing tissue in the digestive system. the condition may look benign but can spread to other parts of the body as they grow
* Leiomyosarcomas
Leiomyosarcomas are the rare and resistant types of colorectal cancer and generally not very responsive to chemotherapy or radiation. They are a malignant abnormal mass of tissue of smooth muscles of the colon, comprising between 5–10% of soft tissue sarcomas.
* Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.
* Melanomas
Melanomas are a rare malignant tumor of cells that produce the dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.
Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the treatment of colorectal cancer, researchers investigated whether dietary lutein/zeaxanthin, the major compounds found in carotenoid intake affect colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism.
The experiment included 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, that answered the semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype.
Based on the returned questionnaire differentiation, the highest quartile of lutein/zeaxanthin consumption was inversely associated with colorectal cancer risk.
In genotype analysis, patients who carry G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared to that of AA carriers.
Furthermore, patients with G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk, particularly in rectal cancer compared to that of AA carriers with low lutein/zeaxanthin intakes.
The results strongly suggested that carotenoids major compounds lutein/zeaxanthin has a strong implication on the colorectal cancer risk in patients with DICER1 rs3742330 genotype.
Dr. Kim J, the lead scientist after taking into account co and confounders wrote in the final report, " colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism".
Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells by Cha KH1, Koo SY, Lee DU. (PubMed)
Rectal cancer
(1) (1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk by Kim J1, Lee J1, Oh JH2, Chang HJ2, Sohn DK2, Kwon O3, Shin A4, Kim J. (PubMed)
(3) Bowel (Colorectal ) Cancer by Kyle J. Norton
The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colorectal cancer is cancer located in the colon or rectum caused alternation of cell DNA. Most cases of colorectal cancer begin in the cells on the surface of inner ling tissue in either the colon or rectum, before multiplying to form a tumor.
Colorectal cancer is relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the statistics provided by the American Cancer Society, in the US,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in 2019.
Additionally, colorectal cancer will also cause the death of 51,020 Americans in 2019.
Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.
Besides adenocarcinomas, the common type of colorectal cancer originated in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, other types of colorectal tumors include
* Carcinoid
Carcinoid is an unusual type of slow growth neuroendocrine tumor in the hormone-producing tissue in the digestive system. the condition may look benign but can spread to other parts of the body as they grow
* Leiomyosarcomas
Leiomyosarcomas are the rare and resistant types of colorectal cancer and generally not very responsive to chemotherapy or radiation. They are a malignant abnormal mass of tissue of smooth muscles of the colon, comprising between 5–10% of soft tissue sarcomas.
* Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.
* Melanomas
Melanomas are a rare malignant tumor of cells that produce the dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.
Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the treatment of colorectal cancer, researchers investigated whether dietary lutein/zeaxanthin, the major compounds found in carotenoid intake affect colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism.
The experiment included 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, that answered the semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype.
Based on the returned questionnaire differentiation, the highest quartile of lutein/zeaxanthin consumption was inversely associated with colorectal cancer risk.
In genotype analysis, patients who carry G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared to that of AA carriers.
Furthermore, patients with G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk, particularly in rectal cancer compared to that of AA carriers with low lutein/zeaxanthin intakes.
The results strongly suggested that carotenoids major compounds lutein/zeaxanthin has a strong implication on the colorectal cancer risk in patients with DICER1 rs3742330 genotype.
Dr. Kim J, the lead scientist after taking into account co and confounders wrote in the final report, " colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism".
Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells by Cha KH1, Koo SY, Lee DU. (PubMed)
Rectal cancer
(1) (1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk by Kim J1, Lee J1, Oh JH2, Chang HJ2, Sohn DK2, Kwon O3, Shin A4, Kim J. (PubMed)
(3) Bowel (Colorectal ) Cancer by Kyle J. Norton
Green Tea, A Potent Ingredient in Inhibited Athlete's Foot (Tinea Pedis)
Green tea may have a therapeutic and positive effect in reduced risk and and treatment of athlete's foot( tinea pedis,), some scientists suggested.
The results of the investigation were reported by several institutes, including the Tokyo Medical and Dental University and published online at medical literature.
Green tea is a precious drink processed a number of health benefits known to almost everyone in Asia and the Western world.
Athlete's foot( tinea pedis) is a common skin disease characterized by a fungal infection.
Uncontrolled proliferation of yeast-fungi not only produces pungent odor but also facilitates the risks of small vesicles, fissures, scaling, and maceration.
Green tea is not one of the favorite natural ingredient used for treatment of athlete's foot (tinea pedis) in compared to the formula of aromatic oil powder-compound consisting of arrowroot, baking soda, basil oil, tea tree oil, sage oil, and clove oil which has been proven effective in 48 hours injection with enclosed feet in shoes and socks.
In the reaffirmed green tea polyphenols (GTP) in inhibited Trichophyton in vitro, researchers at the Tokyo Medical and Dental University launched an evaluation of the effects of GTP on interdigital tinea pedis in a total of 94 infected patients.
The enrolled patients were assigned either to a lukewarm water foot bath containing GTP(0.1% green tea polyphenol solution: 89.5% catechins) or placebo.
The foot baths were given once daily with feet cleaned with mild soap and rinsed with warm water before submerging into the warm GTP foot bath for 15 minutes up to the ankles.
Patients were also given instruction not to dry off the liquids after 15 minutes to ensure further skin penetration of green tea concentration.
At the end of 12 experiments, researchers found that either GTP or placebo exerted a significant reduction in the size of the affected area, the recurrence rate, and the microscopy findings.
In the overall assessment, after taking into account other co and confounders, the green tea treatment group demonstrated significant improvements compared to the placebo group.
These results suggested that green tea (GTP) may process a strong antifungal activity in reduced the symptoms expression of an athlete's foot (tinea pedis), including redness, skin peeling, softening of the tissue.
Therefore, people with long term of athlete's foot (tinea pedis) may be beneficiary by applying the extract in practical use without inducing any adverse effects.
Taken together, green tea polyphenols may be considered as a natural treatment of athlete's foot (tinea pedis), however, due to the small sample size, researchers suggested that large sample size and multi centers investigation are necessary to reaffirm this viability.
Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Effects of a foot bath containing green tea polyphenols on interdigital tinea pedis by Ikeda S1, Kanoya Y, Nagata S.(PubMed)
(2) Athlete’s Foot (tinea pedis) by Centers for Disease Control and Prevention
The results of the investigation were reported by several institutes, including the Tokyo Medical and Dental University and published online at medical literature.
Green tea is a precious drink processed a number of health benefits known to almost everyone in Asia and the Western world.
Athlete's foot( tinea pedis) is a common skin disease characterized by a fungal infection.
Uncontrolled proliferation of yeast-fungi not only produces pungent odor but also facilitates the risks of small vesicles, fissures, scaling, and maceration.
Green tea is not one of the favorite natural ingredient used for treatment of athlete's foot (tinea pedis) in compared to the formula of aromatic oil powder-compound consisting of arrowroot, baking soda, basil oil, tea tree oil, sage oil, and clove oil which has been proven effective in 48 hours injection with enclosed feet in shoes and socks.
In the reaffirmed green tea polyphenols (GTP) in inhibited Trichophyton in vitro, researchers at the Tokyo Medical and Dental University launched an evaluation of the effects of GTP on interdigital tinea pedis in a total of 94 infected patients.
The enrolled patients were assigned either to a lukewarm water foot bath containing GTP(0.1% green tea polyphenol solution: 89.5% catechins) or placebo.
The foot baths were given once daily with feet cleaned with mild soap and rinsed with warm water before submerging into the warm GTP foot bath for 15 minutes up to the ankles.
Patients were also given instruction not to dry off the liquids after 15 minutes to ensure further skin penetration of green tea concentration.
At the end of 12 experiments, researchers found that either GTP or placebo exerted a significant reduction in the size of the affected area, the recurrence rate, and the microscopy findings.
In the overall assessment, after taking into account other co and confounders, the green tea treatment group demonstrated significant improvements compared to the placebo group.
These results suggested that green tea (GTP) may process a strong antifungal activity in reduced the symptoms expression of an athlete's foot (tinea pedis), including redness, skin peeling, softening of the tissue.
Therefore, people with long term of athlete's foot (tinea pedis) may be beneficiary by applying the extract in practical use without inducing any adverse effects.
Taken together, green tea polyphenols may be considered as a natural treatment of athlete's foot (tinea pedis), however, due to the small sample size, researchers suggested that large sample size and multi centers investigation are necessary to reaffirm this viability.
Reprint of this article is welcome with author name and link to the article sources intact https://kylejnorton.blogspot.ca/
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Effects of a foot bath containing green tea polyphenols on interdigital tinea pedis by Ikeda S1, Kanoya Y, Nagata S.(PubMed)
(2) Athlete’s Foot (tinea pedis) by Centers for Disease Control and Prevention
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