Cancer is a group of chronic diseases caused by irregular cell growth in the tissue of a specific organ due to the alternation of cell DNA.
Colon cancer is a chronic condition characterized by uncontrolled cell growth in the colon tissue.
Most cases of colon cancer start with the alternation of cells DNA in the cells on the surface of the inner lining colon tissue before proliferating into deeper tissues to form a tumor through abnormal cell cycle division.
The colon formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colon cancer is relatively very common, slowly growing and progressing cancer.
According to the statistics provided by the American Cancer Society, in 2019, colorectal cancer including colon and rectal cancer is the third most common cancer diagnosed in both men and women in the United States.
In 2019, 101,420 people in the US will be diagnosed with colon cancer.
Most common symptoms of colon cancer are a persistent change in your bowel habits, including diarrhea or constipation, blood in your stool, persistent abdominal discomforts, such feeling that your bowel doesn't empty completely accompanied by some general symptoms shared by other types of cancer.
The exact causes of colon cancer are unknown. However, out of many risk factors associated with the onset of the disease, aging may have a strong implication involved in cancer, as most cases of the colon are found in the older population.
Dr. O Ng and colleagues in a joint study led by the University of Nottingham wrote, "The prevalence of colorectal cancer is increasing in the elderly. We examined the treatment and outcomes in our institution of patients aged over 85 years with proven colorectal adenocarcinoma".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potential compound for the treatment of colon cancer with no side effect, researchers examined the effects of Withaferin-A, a withanolide derived from the leaf extract of W. somnifera, anti-colon tumor activity.
On human colorectal cancer (HCT116) cells, the phytochemical not only inhibited the proliferation but also the migration of the tested cancer cells in a concentration-dependent manner.
In other words, Withaferin-A exhibited cell cycle arrest and blocking cancer cell spreading.
Furthermore, the administration of withaferin-A attenuated the expression of pro-inflammatory cytokines activated by protein (STAT3) associated with the development and progression of colon cancer.
On HCT116 cells xenograft tumors and generated in Balb/c nude mice, withaferin-A showed a strong activity in which a significant decrease in the volume and weight of tumors, compared to untreated controls.
Based on the finding, researchers said, "The present study suggests that withaferin-A holds the potential to be developed as a small molecule inhibitor of STAT3 for the treatment of HCT116".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of colon cancer in vitro and vivo.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity by Choi BY1, Kim BW. (PubMed)
(2) Immunomodulatory effects of Withania somnifera on azoxymethane-induced experimental colon cancer in mice by Muralikrishnan G1, Dinda AK, Shakeel F. (PubMed)
(3) Colorectal cancer outcomes in patients aged over 85 years by O Ng,1 E Watts,2 CA Bull,2 R Morris,3 A Acheson,2 and A Banerjea. (PMC)
Friday, October 11, 2019
Green Tea and Its Bioactive Polyphenol EGCG Kill Bacteria That Cause Carbuncle
Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of carbuncle, a skin disease, some scientists suggested.
Carbuncle is a collection of boils developed under the skin caused by bacterial infection of hair follicles in the induction of swelling.
Although the infections are most likely developing on the follicles of the hair, they can also appear on other areas of the body such as the buttocks, thighs, groin, and armpits.
Researchers suggested that people who are older age, obesity, poor hygiene, and poor health are most likely associated with increased risk of carbuncles.
However, chronic skin conditions, chronic kidney disease,.... and liver disease are also increased the prevalent risk of the infection.
According to University of Miami School of Medicine, "Skin infections account for a significant portion of dermatologic disease, often resulting in or as a consequence of a disruption in the skin's integrity" and " The infections presented herein include impetigo, ecthyma, folliculitis, carbuncles/furuncles, cellulitis, toxic shock syndrome, and ecthyma gangrenosum"(4).
The differentiation hinted that people with carbuncle are also susceptible to the onset of skin disease.
Green tea is a precious drink processed number of health benefits known to almost everyone in Asia and the Western world.
In the searching of the natural ingredient to replace the use of antibiotics in the treatment of bacterial infection of carbuncle, researchers at the J the Rockefeller University found that epigallocatechin-3-gallate isolated from green tea extracts exerts a significant effect in inhibiting the activity of Staphylococcus aureus (S. aureus), a leading candidate in exhibited risk of carbuncle.
Further analysis also suggested that application EGCG inhibited the Typhimurium type III protein effectors in restriction of bacterial invasion into tested cells.
The type III secretion system of Salmonella typhimurium is found to have a direct effect in the translocation of proteins into host cells in initiated infection.
Dr. Tsou LK, the lead authors said, "These results reveal additional dietary plant metabolites that can attenuate bacterial virulence and infection of host cells".
Some researchers at the Mashhad University of Medical Sciences, after lengthy searching for effective agent without inducing intolerant adverse effect for treatment of bacterial infection, found that green tea catechins, the major green tea polyphenols, shows antimicrobial activity against resistant pathogens, including Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa).
In compared of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates, inhibited bacterial activities by a minimum inhibitory concentration (MICs) of gentamicin in the range of 0.312 - 320 μg/mL and The MIC values of both types of catechins were 62.5 - 250 μg/ mL. in compared to no effect in methylxanthines application.
Interestingly, the dose of gentamicin was reduced substantially if adding doses of green tea extract and catechin according to the MICs.
These results indicated that green extract and major bioactive polyphenol catechin may be used alone or combined with gentamicin for treatment of bacterial infection, including carbuncle without inducing the g adverse effect.
Dr. Fazly Bazzaz BS, the lead scientist after taking into account of other co and confounders said, "green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains" and "combinations of gentamicin with these natural compounds might be a promising approach to combat microbial resistance".
Additionally, the evaluate the antibacterial activity of the Indonesian water-soluble green tea extract, Camellia sinensis, against clinical isolates of methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA) and multi-drug resistant Pseudomonas aeruginosa (MDR-P. aeruginosa conducted by theUniversity of Indonesia suggested
* The inhibition zone diameters of green tea extracts for S. aureus ATCC 25923 and MRSA were 18.970 ± 0.287 mm, and (19.130 ± 0.250) mm respectively.
* The inhibition zone diameter for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were (17.550 ± 0.393) mm and (17.670 ± 0.398) mm respectively.
*The MIC of green tea extracts against S. aureus ATCC 25923 and MRSA were 400 µg/mL and 400 µg/mL, respectively.
And
* The MIC for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa was 800 µg/mL, and 800 µg/mL, respectively.
Taking all together, green tea extract and its bioactive polyphenol catechin may be considered as a functional food in reduced risk and treatment of carbuncle caused by Staphylococcus aureus (S. aureus).
Howvwer, intake of green tea extract should be taken with extreme care as acute liver toxicity has been reported by numbers of medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells by Tsou LK1, Yount JS2, Hang HC3.(PubMed)
(2) Effect of Catechins, Green tea Extract and Methylxanthines in Combination with Gentamicin Against Staphylococcus aureus and Pseudomonas aeruginosa: - Combination therapy against resistant bacteria by Fazly Bazzaz BS1, Sarabandi S2, Khameneh B3, Hosseinzadeh H4.(PubMed)
(3) Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa by Radji M1, Agustama RA, Elya B, Tjampakasari CR.(PubMed)
(4) Common bacterial skin infections by Trent JT1, Federman D, Kirsner RS(PubMed)
Carbuncle is a collection of boils developed under the skin caused by bacterial infection of hair follicles in the induction of swelling.
Although the infections are most likely developing on the follicles of the hair, they can also appear on other areas of the body such as the buttocks, thighs, groin, and armpits.
Researchers suggested that people who are older age, obesity, poor hygiene, and poor health are most likely associated with increased risk of carbuncles.
However, chronic skin conditions, chronic kidney disease,.... and liver disease are also increased the prevalent risk of the infection.
According to University of Miami School of Medicine, "Skin infections account for a significant portion of dermatologic disease, often resulting in or as a consequence of a disruption in the skin's integrity" and " The infections presented herein include impetigo, ecthyma, folliculitis, carbuncles/furuncles, cellulitis, toxic shock syndrome, and ecthyma gangrenosum"(4).
The differentiation hinted that people with carbuncle are also susceptible to the onset of skin disease.
Green tea is a precious drink processed number of health benefits known to almost everyone in Asia and the Western world.
In the searching of the natural ingredient to replace the use of antibiotics in the treatment of bacterial infection of carbuncle, researchers at the J the Rockefeller University found that epigallocatechin-3-gallate isolated from green tea extracts exerts a significant effect in inhibiting the activity of Staphylococcus aureus (S. aureus), a leading candidate in exhibited risk of carbuncle.
Further analysis also suggested that application EGCG inhibited the Typhimurium type III protein effectors in restriction of bacterial invasion into tested cells.
The type III secretion system of Salmonella typhimurium is found to have a direct effect in the translocation of proteins into host cells in initiated infection.
Dr. Tsou LK, the lead authors said, "These results reveal additional dietary plant metabolites that can attenuate bacterial virulence and infection of host cells".
Some researchers at the Mashhad University of Medical Sciences, after lengthy searching for effective agent without inducing intolerant adverse effect for treatment of bacterial infection, found that green tea catechins, the major green tea polyphenols, shows antimicrobial activity against resistant pathogens, including Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa).
In compared of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates, inhibited bacterial activities by a minimum inhibitory concentration (MICs) of gentamicin in the range of 0.312 - 320 μg/mL and The MIC values of both types of catechins were 62.5 - 250 μg/ mL. in compared to no effect in methylxanthines application.
Interestingly, the dose of gentamicin was reduced substantially if adding doses of green tea extract and catechin according to the MICs.
These results indicated that green extract and major bioactive polyphenol catechin may be used alone or combined with gentamicin for treatment of bacterial infection, including carbuncle without inducing the g adverse effect.
Dr. Fazly Bazzaz BS, the lead scientist after taking into account of other co and confounders said, "green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains" and "combinations of gentamicin with these natural compounds might be a promising approach to combat microbial resistance".
Additionally, the evaluate the antibacterial activity of the Indonesian water-soluble green tea extract, Camellia sinensis, against clinical isolates of methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA) and multi-drug resistant Pseudomonas aeruginosa (MDR-P. aeruginosa conducted by theUniversity of Indonesia suggested
* The inhibition zone diameters of green tea extracts for S. aureus ATCC 25923 and MRSA were 18.970 ± 0.287 mm, and (19.130 ± 0.250) mm respectively.
* The inhibition zone diameter for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were (17.550 ± 0.393) mm and (17.670 ± 0.398) mm respectively.
*The MIC of green tea extracts against S. aureus ATCC 25923 and MRSA were 400 µg/mL and 400 µg/mL, respectively.
And
* The MIC for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa was 800 µg/mL, and 800 µg/mL, respectively.
Taking all together, green tea extract and its bioactive polyphenol catechin may be considered as a functional food in reduced risk and treatment of carbuncle caused by Staphylococcus aureus (S. aureus).
Howvwer, intake of green tea extract should be taken with extreme care as acute liver toxicity has been reported by numbers of medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells by Tsou LK1, Yount JS2, Hang HC3.(PubMed)
(2) Effect of Catechins, Green tea Extract and Methylxanthines in Combination with Gentamicin Against Staphylococcus aureus and Pseudomonas aeruginosa: - Combination therapy against resistant bacteria by Fazly Bazzaz BS1, Sarabandi S2, Khameneh B3, Hosseinzadeh H4.(PubMed)
(3) Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa by Radji M1, Agustama RA, Elya B, Tjampakasari CR.(PubMed)
(4) Common bacterial skin infections by Trent JT1, Federman D, Kirsner RS(PubMed)
Thursday, October 10, 2019
Lycopene, Protects the Liver Cells Against the Risk of Hepatic Steatosis
The liver is the largest internal organ that filters the blood from the digestive tract, before passing them to the rest of the body.
The liver also plays an essential role to produce cholesterol to build a strong cell wall, produce steroid hormones and vitamin D and aid the digestive function in food absorption and detoxify chemicals and metabolizes drugs.
Hepatic steatosis is a medical condition that reduces the function of the liver caused by the accumulation of fat in the liver.
In other words, if the intrahepatic fat of your liver is more than 5% of liver weight, you are considered to have hepatic steatosis. Epidemiologically, over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease.
Hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication and/or hepatic disorders.
Most common risk factors associated with the onset of hepatic steatosis are insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, using hepatotoxic medications total parenteral nutrition (TPN).
The increased flux of fatty acids to the liver, de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion are some mechanisms that cause the accumulation of intrahepatic fat.
Out of many prevalent factors involved in the onset of hepatic steatosis, some researchers suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that accelerates the incidence onset.
Dr. Michael D. Roberts, the lead scientist said, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content,...in adult Brown Norway rats".
And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the prevention of liver disease, researchers examined the effects of lycopene on hepatic steatosis in an animal model.
In a model of high-fat diet rats, lycopene not only showed a significant effect against the development of steatohepatitis but also inhibited nonalcoholic steatohepatitis (NASH) in the promotion of the early stage of liver cancer through its antioxidant activity.
In rats induced NAFLD by a hypercholesterolemic and high-fat diet, according to the tested analysis, after 7 weeks, there are clear differences in the classical antioxidant biomarkers and metabolic pattern associated with the inhibition of NAFLD between the diet and intake of lycopene from tomato juice.
Interestingly, tomato juice administration partially reverted the metabolic pattern from a high-fat diet to a normal diet in metabolites without exhibiting the redox state.
Taken altogether, lycopene found in tomato may be considered supplements for the improvement of liver metabolism against the risk liver disease, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months)
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(2) Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice by Ip BC1, Liu C2, Lichtenstein AH3, von Lintig J4, Wang XD. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins,Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)
The liver also plays an essential role to produce cholesterol to build a strong cell wall, produce steroid hormones and vitamin D and aid the digestive function in food absorption and detoxify chemicals and metabolizes drugs.
Hepatic steatosis is a medical condition that reduces the function of the liver caused by the accumulation of fat in the liver.
In other words, if the intrahepatic fat of your liver is more than 5% of liver weight, you are considered to have hepatic steatosis. Epidemiologically, over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease.
Hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication and/or hepatic disorders.
Most common risk factors associated with the onset of hepatic steatosis are insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, using hepatotoxic medications total parenteral nutrition (TPN).
The increased flux of fatty acids to the liver, de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion are some mechanisms that cause the accumulation of intrahepatic fat.
Out of many prevalent factors involved in the onset of hepatic steatosis, some researchers suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that accelerates the incidence onset.
Dr. Michael D. Roberts, the lead scientist said, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content,...in adult Brown Norway rats".
And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the prevention of liver disease, researchers examined the effects of lycopene on hepatic steatosis in an animal model.
In a model of high-fat diet rats, lycopene not only showed a significant effect against the development of steatohepatitis but also inhibited nonalcoholic steatohepatitis (NASH) in the promotion of the early stage of liver cancer through its antioxidant activity.
In rats induced NAFLD by a hypercholesterolemic and high-fat diet, according to the tested analysis, after 7 weeks, there are clear differences in the classical antioxidant biomarkers and metabolic pattern associated with the inhibition of NAFLD between the diet and intake of lycopene from tomato juice.
Interestingly, tomato juice administration partially reverted the metabolic pattern from a high-fat diet to a normal diet in metabolites without exhibiting the redox state.
Taken altogether, lycopene found in tomato may be considered supplements for the improvement of liver metabolism against the risk liver disease, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months)
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(2) Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice by Ip BC1, Liu C2, Lichtenstein AH3, von Lintig J4, Wang XD. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins,Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)
Green Tea Extract EGCG, A Novel Topical Ingredient for Cold Sore, Scientists Found
Green tea may have a therapeutic and positive effect in reduced risk and and treatment of cold sore (herpes simplex labialis infection), some scientists suggested.
Cold sore is a common skin disease characterized by tiny blisters that develop on the lips or around the mouth caused by the infection of herpes simplex virus strain HSV-1 mostly.
Believe it or not, over 80% of the North American population have herpes 1 virus living permanently in their body without causing any health problem. However, the dormant virus can quickly multiple to affect the skin on the lips if the immune system is weakened or triggered by certain conditions such as prolonged stress, a digestive disorder.
The virus is very contagious, anyone who comes to direct contact with an infected person can easily be infected.
Most common symptoms of cold sore include sensations, tingling,,...... pain, or numbness on the lip and skin surround the lip.
Cold sore that appears inside the mouth may be troublesome, as the condition interferes with food injection and speech.
In a number of severe cases, herpes 1 virus may infect the eye, brain, leading to vision loss and certain brain infectious diseases.
Conventional antiviral medicine used for the treatment of cold sore may be effective such as Zovirax, Famvir,..... and valacyclovir, but they can induce certain side effects including digestive discomforts,..., headache, dizziness,.... and tiredness.
In the reaffirmed the efficacy of catechins from the tea plant (Camellia sinensis) therapeutic effect on herpes simplex virus infections in vitro and in vivo, researchers conducted a double-blind, placebo-controlled, randomized trial with 40 participants.
The aim of the joint study is to clinically evaluate a topical proprietary formulation containing lipophilic catechins (AverTeaX, Camellix, LLC, Evans, GA, USA) on recurrent herpes labialis.
In compared to vehicle group treated with 100% glycerin USP, CVS Pharmacies, Inc., Woonsocket, RI, USA), topical application of AverTeaX applied six to eight times daily showed a strong reduction in clinical episode duration (median 4.5 days vs. 9 days) and shortened blistering and ulceration stages within an episode from a median of 3 days to 1 day.
According to the median quality-of-life scores, AverTeaX treated group demonstrated in respect to duration of itching, from a median of 4 days to 1 day, and duration until symptom-free, from a median of 8 days to 4 days.
Interestingly, both groups displayed similar in median scores for itching, pain, burning, swelling, bleeding, and stress.
No adverse effects were found in both groups, during the term of study.
Based on these results, Dr. Zhao M, after taking into account of other co-founders, said, "AverTeaX formulation containing lipophilic catechins effectively inhibited herpes simplex labialis infection with clinical significance".
Additionally, in further analysis to address the green tea extract in reduced expression of HSV in precipitated risk of skin infection, including cold sore and reconfirmed EGCG anti-oxidant activity in inhibited number of plaques in HIV-infected cultured cells, a study to evaluate the efficacy of modified EGCG palmitoyl-EGCG (p-EGCG), as a topical antiviral agent for Herpes Simplex Virus (HSV-1) infections was conducted.
p-EGCG is not toxic to cultured Vero cells, according to the cell viability and cell proliferation assays
According to the results, the application of p-EGCG increased the effectiveness of EGCG as an antiviral agent.
In compared to EGCG topically applied to the skin, one of the primary tissues infected by HSV, green tea polyphenol epigallocatechin gallate (EGCG) with palmitate was a more potent inhibitor of Herpes Simplex Virus 1 (HSV-1).
Observation of other assays used in the experiment, p-EGCG concentrations of 50 µM or higher exerted linearly in blocking the production of infectious HSV-1 particles.
This efficacy suggested that p-EGCG may be considered as a potent and natural ingredient in inhibited HSV-1 adsorption to Vero cells.
Thus, p-EGCG may provide a novel treatment for HSV-1 infections, including cold sore.
The findings suggested that topically green tea used a combination of other herbal ingredients or green tea extract used alone may have a therapeutic potential in the treatment of cold sore caused by herpes simplex virus HSV-1 infection)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula by Zhao M1, Zheng R1, Jiang J1, Dickinson D2, Fu B1, Chu TC3, Lee LH4, Pearl H5, Hsu S6.(PubMed)
(2) Inhibition of Herpes Simplex Virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate by Aline de Oliveira,a Sandra D. Adams,b Lee H. Lee,b Sean R. Murray,c Stephen D. Hsu,d Jeffrey R. Hammond,cDouglas Dickinson,d Ping Chen,e and Tin-Chun Chua(PMC)
Cold sore is a common skin disease characterized by tiny blisters that develop on the lips or around the mouth caused by the infection of herpes simplex virus strain HSV-1 mostly.
Believe it or not, over 80% of the North American population have herpes 1 virus living permanently in their body without causing any health problem. However, the dormant virus can quickly multiple to affect the skin on the lips if the immune system is weakened or triggered by certain conditions such as prolonged stress, a digestive disorder.
The virus is very contagious, anyone who comes to direct contact with an infected person can easily be infected.
Most common symptoms of cold sore include sensations, tingling,,...... pain, or numbness on the lip and skin surround the lip.
Cold sore that appears inside the mouth may be troublesome, as the condition interferes with food injection and speech.
In a number of severe cases, herpes 1 virus may infect the eye, brain, leading to vision loss and certain brain infectious diseases.
Conventional antiviral medicine used for the treatment of cold sore may be effective such as Zovirax, Famvir,..... and valacyclovir, but they can induce certain side effects including digestive discomforts,..., headache, dizziness,.... and tiredness.
In the reaffirmed the efficacy of catechins from the tea plant (Camellia sinensis) therapeutic effect on herpes simplex virus infections in vitro and in vivo, researchers conducted a double-blind, placebo-controlled, randomized trial with 40 participants.
The aim of the joint study is to clinically evaluate a topical proprietary formulation containing lipophilic catechins (AverTeaX, Camellix, LLC, Evans, GA, USA) on recurrent herpes labialis.
In compared to vehicle group treated with 100% glycerin USP, CVS Pharmacies, Inc., Woonsocket, RI, USA), topical application of AverTeaX applied six to eight times daily showed a strong reduction in clinical episode duration (median 4.5 days vs. 9 days) and shortened blistering and ulceration stages within an episode from a median of 3 days to 1 day.
According to the median quality-of-life scores, AverTeaX treated group demonstrated in respect to duration of itching, from a median of 4 days to 1 day, and duration until symptom-free, from a median of 8 days to 4 days.
Interestingly, both groups displayed similar in median scores for itching, pain, burning, swelling, bleeding, and stress.
No adverse effects were found in both groups, during the term of study.
Based on these results, Dr. Zhao M, after taking into account of other co-founders, said, "AverTeaX formulation containing lipophilic catechins effectively inhibited herpes simplex labialis infection with clinical significance".
Additionally, in further analysis to address the green tea extract in reduced expression of HSV in precipitated risk of skin infection, including cold sore and reconfirmed EGCG anti-oxidant activity in inhibited number of plaques in HIV-infected cultured cells, a study to evaluate the efficacy of modified EGCG palmitoyl-EGCG (p-EGCG), as a topical antiviral agent for Herpes Simplex Virus (HSV-1) infections was conducted.
p-EGCG is not toxic to cultured Vero cells, according to the cell viability and cell proliferation assays
According to the results, the application of p-EGCG increased the effectiveness of EGCG as an antiviral agent.
In compared to EGCG topically applied to the skin, one of the primary tissues infected by HSV, green tea polyphenol epigallocatechin gallate (EGCG) with palmitate was a more potent inhibitor of Herpes Simplex Virus 1 (HSV-1).
Observation of other assays used in the experiment, p-EGCG concentrations of 50 µM or higher exerted linearly in blocking the production of infectious HSV-1 particles.
This efficacy suggested that p-EGCG may be considered as a potent and natural ingredient in inhibited HSV-1 adsorption to Vero cells.
Thus, p-EGCG may provide a novel treatment for HSV-1 infections, including cold sore.
The findings suggested that topically green tea used a combination of other herbal ingredients or green tea extract used alone may have a therapeutic potential in the treatment of cold sore caused by herpes simplex virus HSV-1 infection)
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula by Zhao M1, Zheng R1, Jiang J1, Dickinson D2, Fu B1, Chu TC3, Lee LH4, Pearl H5, Hsu S6.(PubMed)
(2) Inhibition of Herpes Simplex Virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate by Aline de Oliveira,a Sandra D. Adams,b Lee H. Lee,b Sean R. Murray,c Stephen D. Hsu,d Jeffrey R. Hammond,cDouglas Dickinson,d Ping Chen,e and Tin-Chun Chua(PMC)
Wednesday, October 9, 2019
Cooked Tomato's Lycopene Protects Protein, Lipid and Cell Damage Against Oxidative Stress in Human Studies
Oxidative stress is a condition characterized by overexpression of free radicals in the body.
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.
Free radical is an unstable atom with a single electron on the outermost ring. Given to its nature, free radical readily donate or intercept an electron from another atom, leading a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.
The antioxidant is a stable atom with a function to inhibit oxidation, come either from dietary sources or produced by the body.
Contrast to general belief, free radical is also needed in moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.
According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.
However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.
Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, pollution are some of the risk factors associated with the increased risk of oxidative stress.
Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributed to aging in humans.
Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.
In a total of 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael 's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin and glutathione peroxidase (GPx).
Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.
In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.
After a month, the participants were randomly divided into groups with 15 members each consumed either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.
According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.
Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation were found to increase substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.
Taken altogether, tomatoes and its major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.
Free radical is an unstable atom with a single electron on the outermost ring. Given to its nature, free radical readily donate or intercept an electron from another atom, leading a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.
The antioxidant is a stable atom with a function to inhibit oxidation, come either from dietary sources or produced by the body.
Contrast to general belief, free radical is also needed in moderated amount for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.
According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.
However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.
Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, pollution are some of the risk factors associated with the increased risk of oxidative stress.
Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributed to aging in humans.
Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".
Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.
In a total of 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael 's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin and glutathione peroxidase (GPx).
Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.
In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.
After a month, the participants were randomly divided into groups with 15 members each consumed either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.
According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.
Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation were found to increase substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.
Taken altogether, tomatoes and its major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)
Green tea and Its Polyphenols for Prevention and Treatment of Colitis
Green tea may have a therapeutic and profound effect on reduced risk and treatment of colitis, some scientists suggested.
Green tea, a precious drink processes a numbers of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Colitis is a medical condition characterized by inflammation of the inner lining of the colon as a result of infection, inflammation caused by other bowel diseases.
In the comparison of the effects of green tea extract epigallocatechin-3-gallate, EGCG and
Piper nigrum (L.) alkaloid piperine in mice colitis induced by oral administration of dextran sodium sulfate randomly assigned to a daily oral administration of 6.9 mg/kg body weight EGCG or Piper nigrum (L.) piperine (2.9 mg/kg body weight) or the combination of the both with piperine used in the combination to enhance the bioavailability of EGCG and untreated controls, researchers at the Münster University Hospital showed that mice group treated with the combination demonstrated a significant effect in reduced weight loss and improved overall survival in compared to non treatment group through inducing lesser histological damages to the colon and reduction of tissue concentrations of malondialdehyde, an indication of decreased oxidative stress.
According to neutrophils accumulation assay, the application of green tea EGCG and piperine displayed a strong activity in reduced ROS expression in the induction of lipid peroxidation through activation of overexpression of antioxidant enzymes such as superoxide dismutase(SOD) and glutathione peroxidase(GPO).
Further examining also found that the combined ingredients induced an also reduced the production of proinflammatory cytokines.
Dr. Brückner M, after taking into account of other con-founders suggested, "the concept of anti-inflammatory properties of EGCG being generally beneficial in the DSS-model of colitis".
Interestingly, in dextran sulfate sodium (DSS)-induced mouse model of colitis, application of green tea EGCG (3.2 mg/g) as a source of drinking fluid for 3 days exerted a significant effect in ameliorated of colon shortening and spleen enlargement caused by injection of DSS and modulated the production of levels inflammatory cytokines of of interleukin 1 beta (IL-1β) and
Interleukin 6 (IL-6), which plays an important role in the regulation of immune and inflammatory responses to acute and chronic infections.
Furthermore, green tea oral administration also decreased levels of tumor necrosis factor-α, a cell-signaling protein in activated systemic inflammation and pro-inflammatory cytokines in the acute phase of reaction and inhibited ROS expression colonic lipid peroxides through antioxidant activity.
Moreover, the bioactive polyphenol EGCG also improved the small intestinal function in reduced leaky gut, associated with the risk of increasing the number of harmful compounds entering the bloodstream.
Further analysis of green tea efficacy in the treatment of colitis, researchers discovered that green tea EGCG also induced weight loss through the binding on the surface of the small intestine in decreased protein and lipid digestion.
In additional evaluation of green tea polyphenols (GrTP, EGCG) and sulfasalazine activity in colitis induced by injection of Dextran sodium sulfate (DSS) to cause deficiency of IL-10 in BALB/c mice, researchers at the University of Kentucky, postulated that the combined administration significantly ameliorates colonic damage and histological scores in a similar manner (GrTP vs. DSS p < 0.05; EGCG, sulfasalazine vs. DSS p < 0.01) and decrease expression of the inflammatory markers TNFα (3-fold), IL-6 (14-fold) as mentioned above.
Importantly, treated mice with both green tea polyphenols (GrTP, EGCG) and sulfasalazine also expressed a huge improvement in antioxidant capacity in inhibition of ROS in an initiated chain reaction to facilitate of plagues formation and inflammation, observed by the activity of bio maker lectin levels.
The information findings insisted that green tea with abundantly selective bioactive polyphenols may be considered as a functional food for the prevention and treatment of colitis. However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity was reported in numbers of cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis by Brückner M1, Westphal S, Domschke W, Kucharzik T, Lügering A.(PubMed)
(2) (-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss by Bitzer ZT1, Elias RJ1, Vijay-Kumar M2, Lambert JD3,4.(PubMed)
(3) Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in ColitisModels by Oz HS1, Chen T, de Villiers WJ.(PubMed)
Green tea, a precious drink processes a numbers of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Colitis is a medical condition characterized by inflammation of the inner lining of the colon as a result of infection, inflammation caused by other bowel diseases.
In the comparison of the effects of green tea extract epigallocatechin-3-gallate, EGCG and
Piper nigrum (L.) alkaloid piperine in mice colitis induced by oral administration of dextran sodium sulfate randomly assigned to a daily oral administration of 6.9 mg/kg body weight EGCG or Piper nigrum (L.) piperine (2.9 mg/kg body weight) or the combination of the both with piperine used in the combination to enhance the bioavailability of EGCG and untreated controls, researchers at the Münster University Hospital showed that mice group treated with the combination demonstrated a significant effect in reduced weight loss and improved overall survival in compared to non treatment group through inducing lesser histological damages to the colon and reduction of tissue concentrations of malondialdehyde, an indication of decreased oxidative stress.
According to neutrophils accumulation assay, the application of green tea EGCG and piperine displayed a strong activity in reduced ROS expression in the induction of lipid peroxidation through activation of overexpression of antioxidant enzymes such as superoxide dismutase(SOD) and glutathione peroxidase(GPO).
Further examining also found that the combined ingredients induced an also reduced the production of proinflammatory cytokines.
Dr. Brückner M, after taking into account of other con-founders suggested, "the concept of anti-inflammatory properties of EGCG being generally beneficial in the DSS-model of colitis".
Interestingly, in dextran sulfate sodium (DSS)-induced mouse model of colitis, application of green tea EGCG (3.2 mg/g) as a source of drinking fluid for 3 days exerted a significant effect in ameliorated of colon shortening and spleen enlargement caused by injection of DSS and modulated the production of levels inflammatory cytokines of of interleukin 1 beta (IL-1β) and
Interleukin 6 (IL-6), which plays an important role in the regulation of immune and inflammatory responses to acute and chronic infections.
Furthermore, green tea oral administration also decreased levels of tumor necrosis factor-α, a cell-signaling protein in activated systemic inflammation and pro-inflammatory cytokines in the acute phase of reaction and inhibited ROS expression colonic lipid peroxides through antioxidant activity.
Moreover, the bioactive polyphenol EGCG also improved the small intestinal function in reduced leaky gut, associated with the risk of increasing the number of harmful compounds entering the bloodstream.
Further analysis of green tea efficacy in the treatment of colitis, researchers discovered that green tea EGCG also induced weight loss through the binding on the surface of the small intestine in decreased protein and lipid digestion.
In additional evaluation of green tea polyphenols (GrTP, EGCG) and sulfasalazine activity in colitis induced by injection of Dextran sodium sulfate (DSS) to cause deficiency of IL-10 in BALB/c mice, researchers at the University of Kentucky, postulated that the combined administration significantly ameliorates colonic damage and histological scores in a similar manner (GrTP vs. DSS p < 0.05; EGCG, sulfasalazine vs. DSS p < 0.01) and decrease expression of the inflammatory markers TNFα (3-fold), IL-6 (14-fold) as mentioned above.
Importantly, treated mice with both green tea polyphenols (GrTP, EGCG) and sulfasalazine also expressed a huge improvement in antioxidant capacity in inhibition of ROS in an initiated chain reaction to facilitate of plagues formation and inflammation, observed by the activity of bio maker lectin levels.
The information findings insisted that green tea with abundantly selective bioactive polyphenols may be considered as a functional food for the prevention and treatment of colitis. However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity was reported in numbers of cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis by Brückner M1, Westphal S, Domschke W, Kucharzik T, Lügering A.(PubMed)
(2) (-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss by Bitzer ZT1, Elias RJ1, Vijay-Kumar M2, Lambert JD3,4.(PubMed)
(3) Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in ColitisModels by Oz HS1, Chen T, de Villiers WJ.(PubMed)
Tuesday, October 8, 2019
How to Prevent Over Expression of Melanin in Induction of Age Spots Naturally, US National Library of Medicine Studies Reveal
Green tea may have a therapeutic and positive effect in reduced age spots caused by overexpression of melanin, some scientists suggested.
People with a light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.
The results of this investigation were carried out by some worldwide institutes, including the Chongqing Institute of Forensic Science.
You can view the publication through some online medical literature if you want to know more about these subjects.
An age spot is the overexpression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,...
Age spots may also be caused by a hormone imbalance in the induction of increased production of melanin, which is responsible for darkening the skin.
Green tea is a precious drink processed number of health benefits and known to almost everyone in Asia and the Western world.
In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that application EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.
Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of the natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.
HA synthase enzymes (HAS) a molecule with the function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environmental stress exposure.
Hyaluronidase ((HYAL) is an enzyme that cleaves HA.
In UVB irradiation conditions, the application of EGCG protected the expression of decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cell's information of free radicals and decreased in cell viability.
Melanin produced in melanocytes, underexposure UVB irradiation with an aim to protect skin cells against UVB radiation damage.
Years of frequent and prolonged sun exposure and overexpression of melanin may induce aging spot
In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of the aging spots due to exposure UVB irradiation
HaCaT widely used in scientific research of epidermis is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.
Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".
Furthermore, in confirmation of green tea efficacy in reduced overexpression of skin pigment by evaluating the fatty acids contents in the green tea oil, researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.
A single application of each fatty acid demonstrated strong protection of the cell viabilities through their antioxidant activity.
Moreover, the antioxidant activity of 3% tea seed oil exerted greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.
Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.
Taking all together, green tea and its bioactive compound such as EGCG may be used as a natural and functional food for reduced overexpression of melanin and skin pigment in the induction of age spots.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1.(PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)
People with a light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.
The results of this investigation were carried out by some worldwide institutes, including the Chongqing Institute of Forensic Science.
You can view the publication through some online medical literature if you want to know more about these subjects.
An age spot is the overexpression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,...
Age spots may also be caused by a hormone imbalance in the induction of increased production of melanin, which is responsible for darkening the skin.
Green tea is a precious drink processed number of health benefits and known to almost everyone in Asia and the Western world.
In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that application EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.
Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of the natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.
HA synthase enzymes (HAS) a molecule with the function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environmental stress exposure.
Hyaluronidase ((HYAL) is an enzyme that cleaves HA.
In UVB irradiation conditions, the application of EGCG protected the expression of decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cell's information of free radicals and decreased in cell viability.
Melanin produced in melanocytes, underexposure UVB irradiation with an aim to protect skin cells against UVB radiation damage.
Years of frequent and prolonged sun exposure and overexpression of melanin may induce aging spot
In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of the aging spots due to exposure UVB irradiation
HaCaT widely used in scientific research of epidermis is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.
Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".
Furthermore, in confirmation of green tea efficacy in reduced overexpression of skin pigment by evaluating the fatty acids contents in the green tea oil, researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.
A single application of each fatty acid demonstrated strong protection of the cell viabilities through their antioxidant activity.
Moreover, the antioxidant activity of 3% tea seed oil exerted greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.
Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.
Taking all together, green tea and its bioactive compound such as EGCG may be used as a natural and functional food for reduced overexpression of melanin and skin pigment in the induction of age spots.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1.(PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)
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