Stroke is the third leading cause of death. Approximate 1/4 of all stroke victims die as a direct result of the stroke or its complications.
Stroke is caused by the accumulation of cholesterol and other substances that build up the arterial walls. In other words, if cholesterol building up in the arteries is blocking the circulation of blood in any part of the body causing oxygen not to be delivered to the brain, leading to the death of some cells in the brain.
According to the statistics, every year, more than 790,000 people suffer a stroke, including 600,000 of these are first attacks, and 185,000 are recurrent attacks. Most cases of stroke occur in people over the age of 65.
Myocardial infarction is the severe and medical emergency characterized by the obstruction of the blood supply to the brain, causing local brain neurons death. Prompt treatment can minimize brain damage and potential post disease complications.
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.
The exact causes of a blood clot to induce acute brain infarction are unknown. Plaques accumulation in the arteries associated with hardening and stiffing arterial walls is a leading cause of cardiovascular disease, including stroke.
The trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm or leg, headache and the trouble with walking are some of the most common symptoms found in patients with post-myocardial infarction.
Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm or leg, trouble with seeing in one or both eyes.
Although, there are many factors associated with the risk of acute infarction. some researchers suggested an unhealthy diet may have a strong and negative implication on the onset of the condition.
Dr. Guo J, the lead scientist at the Peking Union Medical College & Chinese Academy of Medical Sciences wrote, "Several dietary frequencies (serves per week) including vegetables, fruits and tofu were closely associated with a decrease of AMI risk. Carbohydrate pattern showed a weak relationship with AMI. We observed a U-shaped association between frequencies of fat and protein pattern and AMI risk. Excessive fat intake increased the AMI risk".
Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.
In the concerns of elevated homocysteine levels associated with a higher risk of cardiovascular disease, researchers examined the effect of dietary folate found in green leafy vegetables, such as green beans intake against nonfatal myocardial infarction.
In a case a controlled study in three tertiary hospitals of Pamplona, Spain, between 1999 and 2001, researchers examined the study physicians enrolled 171 patients less than 80 years of age with a first nonfatal myocardial infarction and 171 control patients matched by age, sex, hospital and calendar month.
According to the tested differentiation, only 6% of participants were taking folate vitamin supplements and the main sources of folate were found in dietary green leafy vegetables, green beans, oranges, peppers, and lettuces.
More importantly, the top three quartiles of folate intake of above 340 microg/day) had a matched RR of myocardial infarction of 0.57 (CI = 0.35-0.94), compared with the lowest quartile of intake.
In other words, folate intake from green bean showed a linear dose-dependent on the reduced risk of myocardial infarction
Based on the results, researchers suggested. "Our results in a Mediterranean population with natural plant foods as the main source of folate provide further evidence to support the hypothesis that dietary folate intake may be an independent protective factor for myocardial infarction".
Taken altogether, green beans may be considered a functional food for the prevention of myocardial infarction, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary folate and the risk of nonfatal myocardial infarction by Hernández-Díaz S1, Martínez-Losa E, Fernández-Jarne E, Serrano-Martínez M, Martínez-González MA. (PubMed)
(2) Influence of dietary patterns on the risk of acute myocardial infarction in China population: the INTERHEART China study by Guo J1, Li W, Wang Y, Chen T, Teo K, Liu LS, Yusuf S; INTERHEART China study investigators. (PubMed)
Sunday, October 20, 2019
Green Tea and Its' Polyphenols (GTPs) That Protect Our Bodily Skin Against the Onset of Cancer, Scientists Say
Green tea may have a strong and positive effect on reduced risk and treatment of skin cancer, some scientists suggested.
Skin cancer is a medical condition characterized by irregular cell growth in the tissues of the skin.
At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.
According to statistics, approximately, 87,110 new cases of invasive melanoma are diagnosed in the U.S every year.
The exact causes of skin cancer are unknown. Researchers believed that there are a set of factors that can have the substantial effect to initiate the onset of skin cancer.
Truly, according to the studies, people who have fair skin, regardless of skin color, a history of sunburns, excessive sun exposure, including occupations which are required to work outside during Summar months, moles, family history of skin cancer. and previous and personal history of skin cancer is at the increased risk of skin cancer or recurrence of skin cancer.
The American Institute for Cancer Research, certain lifestyle habits can increase the risk of skin cancer, such as drinking too much coffee, excessive alcohol drinking and long-term intake of certain medications in suppressing the immune system.
Green tea a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world.
The evaluation of green tea effect in overexposure to environmental solar ultraviolet (UV) radiation (290-400 nm) which has been found to increase risk of the development of melanoma and non-melanoma skin cancers in mice model showed that oral administration of green tea polyphenols (GTPs) in drinking water or the topical application of EGCG prevents UVB-induced skin tumor development in tested subjects.
Particularly, (-)-Epigallocatechin-3-gallate (EGCG), the major and most photoprotective polyphenolic component of green tea also exhibited a protective activity against UV in induction of skin cancer, through induction of immunoregulatory cytokine interleukin (IL) 12 in differentiation of naive T cells into Th1 cells and acted as T cell-stimulating factor in stimulate the growth and function of T cells.
Moreover, interleukin (IL) 12 also demonstrated a significant effect as an antagonist against immunosuppression induced by solar/ultraviolet (UV) radiation by restoring immune responses and also stimulating DNA repair.
Further analysis also indicated that green tea (-)-Epigallocatechin-3-gallate (EGCG) also inhibited UV in the induction of skin tumors; the angiogenetic effect in the stimulated production of new blood vessels to
provide nutrients and oxygen for cancer cell proliferation and survival and initiated cytotoxic T lymphocyte cells in induced cancer and infectious and damage cell apoptosis.
Interestingly, additional study of green tea polyphenols (GTPs) in prevention of UVB irradiated (80 mJ/cm(2)) 3 times each week for 24 wk in induced skin cancer in mice divided in to group consumed water and group fed with water containing 2 g/L GTPs, showed that group treated with GTPs displayed a significantly reduced UVB-induced tumor incidence by 35%, tumor multiplicity by 63%, and tumor growth by 55% in compared to non treatment group.
Group treated with GTPs+UVB also demonstrated a reduced expression of the matrix metalloproteinases (MMP)-2 and MMP-9, which are activator associated with progression from benign to advanced cancer and enhanced expression of specific endogenous tissue inhibitors of metalloproteinases (TIMPs), tissues inhibitor of MMP in skin tumors in compared to mice treated with UVB alone.
Furthermore, GTPs+UVB group also reduced expressions of CD31 and vascular endothelial growth factor, inactivated development of new blood vessel to nourish skin tumor cells proliferation and site expansion and inhibited expression of proliferating cell nuclear antigen, a key factor in DNA replication and cell cycle regulation in skin cancer in compared to UVB group.
More importantly, mice treated with GTPs+UVB group also showed more cytotoxic CD8(+) T cells in the tumors in compared to the UVB group by exhibited greater activation of caspase-3 expression in induced apoptosis of the tumor cells.
The information findings suggested a potential and therapeutic effect of green tea and its bioactive polyphenols (GTPs) in attenuated risk, progression, and treatment of melanoma and non-melanoma skin cancers.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Prevents Skin Cancer by Two Mechanisms by Navid Bouzari, Yvonne Romagosa, Robert S. Kirsner(PubMed)
(2) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK. (PubMed)
(3) Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors by Mantena SK1, Meeran SM, Elmets CA, Katiyar SK. (PubMed)
Skin cancer is a medical condition characterized by irregular cell growth in the tissues of the skin.
At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.
According to statistics, approximately, 87,110 new cases of invasive melanoma are diagnosed in the U.S every year.
The exact causes of skin cancer are unknown. Researchers believed that there are a set of factors that can have the substantial effect to initiate the onset of skin cancer.
Truly, according to the studies, people who have fair skin, regardless of skin color, a history of sunburns, excessive sun exposure, including occupations which are required to work outside during Summar months, moles, family history of skin cancer. and previous and personal history of skin cancer is at the increased risk of skin cancer or recurrence of skin cancer.
The American Institute for Cancer Research, certain lifestyle habits can increase the risk of skin cancer, such as drinking too much coffee, excessive alcohol drinking and long-term intake of certain medications in suppressing the immune system.
Green tea a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world.
The evaluation of green tea effect in overexposure to environmental solar ultraviolet (UV) radiation (290-400 nm) which has been found to increase risk of the development of melanoma and non-melanoma skin cancers in mice model showed that oral administration of green tea polyphenols (GTPs) in drinking water or the topical application of EGCG prevents UVB-induced skin tumor development in tested subjects.
Particularly, (-)-Epigallocatechin-3-gallate (EGCG), the major and most photoprotective polyphenolic component of green tea also exhibited a protective activity against UV in induction of skin cancer, through induction of immunoregulatory cytokine interleukin (IL) 12 in differentiation of naive T cells into Th1 cells and acted as T cell-stimulating factor in stimulate the growth and function of T cells.
Moreover, interleukin (IL) 12 also demonstrated a significant effect as an antagonist against immunosuppression induced by solar/ultraviolet (UV) radiation by restoring immune responses and also stimulating DNA repair.
Further analysis also indicated that green tea (-)-Epigallocatechin-3-gallate (EGCG) also inhibited UV in the induction of skin tumors; the angiogenetic effect in the stimulated production of new blood vessels to
provide nutrients and oxygen for cancer cell proliferation and survival and initiated cytotoxic T lymphocyte cells in induced cancer and infectious and damage cell apoptosis.
Interestingly, additional study of green tea polyphenols (GTPs) in prevention of UVB irradiated (80 mJ/cm(2)) 3 times each week for 24 wk in induced skin cancer in mice divided in to group consumed water and group fed with water containing 2 g/L GTPs, showed that group treated with GTPs displayed a significantly reduced UVB-induced tumor incidence by 35%, tumor multiplicity by 63%, and tumor growth by 55% in compared to non treatment group.
Group treated with GTPs+UVB also demonstrated a reduced expression of the matrix metalloproteinases (MMP)-2 and MMP-9, which are activator associated with progression from benign to advanced cancer and enhanced expression of specific endogenous tissue inhibitors of metalloproteinases (TIMPs), tissues inhibitor of MMP in skin tumors in compared to mice treated with UVB alone.
Furthermore, GTPs+UVB group also reduced expressions of CD31 and vascular endothelial growth factor, inactivated development of new blood vessel to nourish skin tumor cells proliferation and site expansion and inhibited expression of proliferating cell nuclear antigen, a key factor in DNA replication and cell cycle regulation in skin cancer in compared to UVB group.
More importantly, mice treated with GTPs+UVB group also showed more cytotoxic CD8(+) T cells in the tumors in compared to the UVB group by exhibited greater activation of caspase-3 expression in induced apoptosis of the tumor cells.
The information findings suggested a potential and therapeutic effect of green tea and its bioactive polyphenols (GTPs) in attenuated risk, progression, and treatment of melanoma and non-melanoma skin cancers.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Prevents Skin Cancer by Two Mechanisms by Navid Bouzari, Yvonne Romagosa, Robert S. Kirsner(PubMed)
(2) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK. (PubMed)
(3) Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors by Mantena SK1, Meeran SM, Elmets CA, Katiyar SK. (PubMed)
Saturday, October 19, 2019
Herbal Turmeric, the Best Anti-Neuroinflammatory Remedy
Neuroinflammation is a medical condition characterized by the inflammation of the central nervous tissues, including the brain and spinal cord.
There many risk factors associated with the onset of neuroinflammation similar to other tissues inflammation, including infection, traumatic brain injury, toxic metabolites, or autoimmunity.
Inflammation is a natural response of the immune system in which the macrophages of the first defense stimulates the production of blood palette to cover the wound in case of injury and production of proinflammatory cytokines to the site of infection to fence off the foreign pathogens.
Inflammation also can be triggered by the immune mistakenly attacked the body tissues in cases of autoimmune disease.
Neuroinflammatory disease can be acute or chronic. Chronic neuroinflammation that leads to the activation of glial cells and the recruitment of inflammatory cytokines into the brain is found to associate with neurodegenerative diseases.
Most cases of the neuroinflammatory disease associated with the loss of neuronal structure and function.can be measured by the typical inflammatory markers, including CSF Aβ1-42, tau and p-tau181, and a panel of 37 neuroinflammatory markers in patients with Alzheimer's disease.
Dr. WEI-WEI CHEN, the lead scientist in the investigation of the role of neuroinflammation in neurodegenerative diseases, wrote, "recent data have identified the inflammatory process as being closely linked with multiple neurodegenerative pathways, which are associated with depression, a consequence of neurodegenerative disease".
And, "Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia. These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments".
In other words, an acute neuroinflammatory response that, if unresolved, can lead to chronic neuroinflammation, leading to chronic low-grade neurodegenerative disease.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the treatment of neuroinflammation, researchers examined the neuron protective activity on curcumin, amain curcuminoid present in turmeric.
According to the tested assays, curcumin dose-dependently inhibited Pam3CSK4, the inflammatory mediators induced the release of proinflammatory cytokines such as nitric oxide, PGE2, and TNF-α secretion.
The secretion of inflammatory mediators was stimulated by the increase in the expression of HO-1, a cytoprotective and antiapoptotic enzyme, which plays an important protective role by modulating oxidative stress.
Furthermore, curcumin also inhibited neuroinflammation by decreasing the production of macrophages found in the central nervous system (CNS) induced by the inflammatory mediators.
Based on the findings, researchers said, "The results of the present study suggest that curcumin may be a novel treatment for neuroinflammation-mediated neurodegenerative disorders".
In vivo, curcumin also exerted a significantly anti-nociceptive and anti-neuroinflammatory effect on arthritic pain in rats.
Moreover, repeated intrathecal injection of curcumin reversed CFA-induced pain hypersensitivity with affecting the joint edema.
Levels of proinflammation observed by the presence of glial cells and the production of inflammatory mediators induced by the injection of CFA were reduced by the injection of curcumin.
Additonally, the protein associated with the regulation of the migration and infiltration of monocytes/macrophages in the spinal cord was also inhibited in the curcumin treatment group.
Dr. Chen JJ, the lead scientist said, " intrathecal curcumin attenuates arthritic pain by inhibiting glial activation and the production of inflammatory mediators in the spinal cord, suggesting a new application of curcumin for the treatment of arthritic pain".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of neuroinflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells by Jin M1, Park SY2, Shen Q1, Lai Y1, Ou X1, Mao Z1, Lin D1, Yu Y1, Zhang W. (PubMed)
(2) Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis by Chen JJ1, Dai L2, Zhao LX3, Zhu X4, Cao S4, Gao YJ. (PubMed)
(3) Role of neuroinflammation in neurodegenerative diseases (Review) by WEI-WEI CHEN, XIA ZHANG, and WEN-JUAN HUANG. (PMC)
There many risk factors associated with the onset of neuroinflammation similar to other tissues inflammation, including infection, traumatic brain injury, toxic metabolites, or autoimmunity.
Inflammation is a natural response of the immune system in which the macrophages of the first defense stimulates the production of blood palette to cover the wound in case of injury and production of proinflammatory cytokines to the site of infection to fence off the foreign pathogens.
Inflammation also can be triggered by the immune mistakenly attacked the body tissues in cases of autoimmune disease.
Neuroinflammatory disease can be acute or chronic. Chronic neuroinflammation that leads to the activation of glial cells and the recruitment of inflammatory cytokines into the brain is found to associate with neurodegenerative diseases.
Most cases of the neuroinflammatory disease associated with the loss of neuronal structure and function.can be measured by the typical inflammatory markers, including CSF Aβ1-42, tau and p-tau181, and a panel of 37 neuroinflammatory markers in patients with Alzheimer's disease.
Dr. WEI-WEI CHEN, the lead scientist in the investigation of the role of neuroinflammation in neurodegenerative diseases, wrote, "recent data have identified the inflammatory process as being closely linked with multiple neurodegenerative pathways, which are associated with depression, a consequence of neurodegenerative disease".
And, "Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia. These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments".
In other words, an acute neuroinflammatory response that, if unresolved, can lead to chronic neuroinflammation, leading to chronic low-grade neurodegenerative disease.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the treatment of neuroinflammation, researchers examined the neuron protective activity on curcumin, amain curcuminoid present in turmeric.
According to the tested assays, curcumin dose-dependently inhibited Pam3CSK4, the inflammatory mediators induced the release of proinflammatory cytokines such as nitric oxide, PGE2, and TNF-α secretion.
The secretion of inflammatory mediators was stimulated by the increase in the expression of HO-1, a cytoprotective and antiapoptotic enzyme, which plays an important protective role by modulating oxidative stress.
Furthermore, curcumin also inhibited neuroinflammation by decreasing the production of macrophages found in the central nervous system (CNS) induced by the inflammatory mediators.
Based on the findings, researchers said, "The results of the present study suggest that curcumin may be a novel treatment for neuroinflammation-mediated neurodegenerative disorders".
In vivo, curcumin also exerted a significantly anti-nociceptive and anti-neuroinflammatory effect on arthritic pain in rats.
Moreover, repeated intrathecal injection of curcumin reversed CFA-induced pain hypersensitivity with affecting the joint edema.
Levels of proinflammation observed by the presence of glial cells and the production of inflammatory mediators induced by the injection of CFA were reduced by the injection of curcumin.
Additonally, the protein associated with the regulation of the migration and infiltration of monocytes/macrophages in the spinal cord was also inhibited in the curcumin treatment group.
Dr. Chen JJ, the lead scientist said, " intrathecal curcumin attenuates arthritic pain by inhibiting glial activation and the production of inflammatory mediators in the spinal cord, suggesting a new application of curcumin for the treatment of arthritic pain".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of neuroinflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-neuroinflammatory effect of curcumin on Pam3CSK4-stimulated microglial cells by Jin M1, Park SY2, Shen Q1, Lai Y1, Ou X1, Mao Z1, Lin D1, Yu Y1, Zhang W. (PubMed)
(2) Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis by Chen JJ1, Dai L2, Zhao LX3, Zhu X4, Cao S4, Gao YJ. (PubMed)
(3) Role of neuroinflammation in neurodegenerative diseases (Review) by WEI-WEI CHEN, XIA ZHANG, and WEN-JUAN HUANG. (PMC)
Black Tea, The Beverages That Block and Reverse the Onset of Dyspepsia, Naturally, Researchers Reveal
Black and green tea may have a therapeutic and positive effect on the prevention of dyspepsia, some scientists suggested.
Dyspepsia is a digestive condition of ingestion.
The exact causes of dyspepsia are unknown. However, researchers suggested that patients with the onset of a stomach ulcer or acid reflux disease are most susceptible to the condition.
Certain medication such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics (metronidazole, macrolides) and diseases such as irritable bowel syndrome is associated with the increased risk of dyspepsia.
Some researchers also suggested that unhealthy choices of lifestyle such as smoking, excessive alcohol drinking also have a strong impact on the onset of the disease.
Dr. Umapati C. Baragi, the lead scientist in the study of diet and lifestyle in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia) said, "dietary patterns, lifestyle choices, and physical activities play an important role in the etiopathogenesis of Urdhwaga Amlapitta, and it is important for patients to have access to diet and lifestyle modifications. Currently, research in this area is minimal"
Symptoms of dyspepsia include pain in the chest, stomach burning pain, bloating, heartburn, upset stomach,.... digestive discomforts.
If you experience the above symptoms, please check with your doctor to rule out the possibility.
Black tea is a beverage with more oxidization, compared to other teas such as oolong, green, and white teas.
In the investigation of aqueous extract (BTE) and thearubigins isolated from green tea effects in sildenafnil-induced delay in gastric emptying (GE) and small intestinal transit (SIT) in total of 160 mice, randomly assigned to 20 groups with 8 in each group, treated by different or combination of doses of BTE, thearubigins (TRs), sildenafil (SLD), metoclopramide, L-NAME (hydrochloride) and black tea extract researchers found that pretreatment of certain doses of green tea aqueous extract (BTE) and thearubigins significantly reverse motility-delaying effects caused by injection of sildenafnil.
Further differentiation also indicated that additional injection of black tea at 3% and 4.5% increases the function of thearubigins (50 and 60 mg/kg) dose-dependently in promoted dyspepsia in mice in compared to the insignificant effect of the combination of BTE at 6% and thearubigins 70 mg/kg.
Moreover, combination of metoclopramide, a medicine used mainly for treatment of ingestion in people with delayed stomach emptying, BTE 4.5%, thearubigins 60 or nω -Nitro-l-arginine methyl ester hydrochloride (l-NAME) with sildenafil (5 mg/kg) reversed its motility-delaying effects,
This improvement of dyspepsia was partially blocked by application of l-NAME through reducing function nitric oxide and improving gastrointestinal smooth muscle mobility by observation of the pretreatment of l-NAME followed by application of BTE alone or combination of thearubigins 60, BTE + sildenafil, and thearubigins + sildenafil.
Dr. Murad HA, the lead author, after taking into account of confounders said, "BTE 4.5% or TRs 60 mg/kg solution could be considered a reliever therapy for the sildenafil-induced dyspepsia".
Additional investigate the role of hot water extract of black tea [Camellia sinensis (L) in normalizing the changes in the intestinal transit and gastric emptying induced by various ulcerogenic agents in experimental rats found that application of black tea extract significant promotes the intestinal transit and gastric emptying caused by glutathione (GSH) depleting agents, diethyl maleate (DEM) in decreased mucosal content in aid of digestion, indoacetamide (IDA) in reduced stomach acid secretion, gastritis, and mucus thickness on gastric transfer and N-ethyl maleimide (NEM) with function of in significantly reduced the mucosal SH levels and the lesions.
Oral administration of black tea extract (BTE) at 20 ml/kg of a 10% solution once a day for 7 day also expressed a significantly increased the intestinal transit and gastric emptying similarly to those of conventional succimer (60 mg/kg, i.g.), the standard sulfhydryl containing an antiulcer agent
through the restoration of antioxidant of serum GSH level.
However, such increase of intestinal transit induced by BTE was reversed both by N-omega-nitro-L-arginine methyl ester (L-NAME) (25 mg/kg, i.p.) and N-omega-monomethyl-L-arginine (L-NMMA) (25 mg/kg, i.p.), in reduced levels of NO in the aided stomach in the production of gastric acid for digestive function.
Dr. Maity S, the lead author said, "restoration of intestinal nitric oxide synthase (NOS) activity was found to be associated with BTE treatment" and "These results provide evidence that nitric oxide may play a role in BTE-mediated movement of intestinal motility changes and gastric emptying induced by DEM, IDA, and NEM".
Taken together, black tea with plenty of phytochemicals may be considered as a functional food in reducing the risk and treatment of dyspepsia.
However, the intake of tea supplements should be taken with exceptional care to prevent acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Black tea extract and its thearubigins relieve the sildenafil-induced delayed gut motility in mice: a possible role of nitric oxide by Murad HA1, Abdallah HM. (PubMed)
(2) Role of reduced glutathione and nitric oxide in the black tea extract-mediated protection against ulcerogen-induced changes in motility and gastric emptying in rats by Maity S1, Vedasiromoni JR, Chaudhuri L, Ganguly DK. (PubMed)
(3) Gastrointestinal transit during endotoxemia: the role of nitric oxide by Wirthlin DJ1, Cullen JJ, Spates ST, Conklin JL, Murray J, Caropreso DK, Ephgrave KS. (PubMed)
(4) Evaluation of diet and life style in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia) by Umapati C. Baragi and Mahesh Kumar Vyas. (PubMed)
Dyspepsia is a digestive condition of ingestion.
The exact causes of dyspepsia are unknown. However, researchers suggested that patients with the onset of a stomach ulcer or acid reflux disease are most susceptible to the condition.
Certain medication such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics (metronidazole, macrolides) and diseases such as irritable bowel syndrome is associated with the increased risk of dyspepsia.
Some researchers also suggested that unhealthy choices of lifestyle such as smoking, excessive alcohol drinking also have a strong impact on the onset of the disease.
Dr. Umapati C. Baragi, the lead scientist in the study of diet and lifestyle in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia) said, "dietary patterns, lifestyle choices, and physical activities play an important role in the etiopathogenesis of Urdhwaga Amlapitta, and it is important for patients to have access to diet and lifestyle modifications. Currently, research in this area is minimal"
Symptoms of dyspepsia include pain in the chest, stomach burning pain, bloating, heartburn, upset stomach,.... digestive discomforts.
If you experience the above symptoms, please check with your doctor to rule out the possibility.
Black tea is a beverage with more oxidization, compared to other teas such as oolong, green, and white teas.
In the investigation of aqueous extract (BTE) and thearubigins isolated from green tea effects in sildenafnil-induced delay in gastric emptying (GE) and small intestinal transit (SIT) in total of 160 mice, randomly assigned to 20 groups with 8 in each group, treated by different or combination of doses of BTE, thearubigins (TRs), sildenafil (SLD), metoclopramide, L-NAME (hydrochloride) and black tea extract researchers found that pretreatment of certain doses of green tea aqueous extract (BTE) and thearubigins significantly reverse motility-delaying effects caused by injection of sildenafnil.
Further differentiation also indicated that additional injection of black tea at 3% and 4.5% increases the function of thearubigins (50 and 60 mg/kg) dose-dependently in promoted dyspepsia in mice in compared to the insignificant effect of the combination of BTE at 6% and thearubigins 70 mg/kg.
Moreover, combination of metoclopramide, a medicine used mainly for treatment of ingestion in people with delayed stomach emptying, BTE 4.5%, thearubigins 60 or nω -Nitro-l-arginine methyl ester hydrochloride (l-NAME) with sildenafil (5 mg/kg) reversed its motility-delaying effects,
This improvement of dyspepsia was partially blocked by application of l-NAME through reducing function nitric oxide and improving gastrointestinal smooth muscle mobility by observation of the pretreatment of l-NAME followed by application of BTE alone or combination of thearubigins 60, BTE + sildenafil, and thearubigins + sildenafil.
Dr. Murad HA, the lead author, after taking into account of confounders said, "BTE 4.5% or TRs 60 mg/kg solution could be considered a reliever therapy for the sildenafil-induced dyspepsia".
Additional investigate the role of hot water extract of black tea [Camellia sinensis (L) in normalizing the changes in the intestinal transit and gastric emptying induced by various ulcerogenic agents in experimental rats found that application of black tea extract significant promotes the intestinal transit and gastric emptying caused by glutathione (GSH) depleting agents, diethyl maleate (DEM) in decreased mucosal content in aid of digestion, indoacetamide (IDA) in reduced stomach acid secretion, gastritis, and mucus thickness on gastric transfer and N-ethyl maleimide (NEM) with function of in significantly reduced the mucosal SH levels and the lesions.
Oral administration of black tea extract (BTE) at 20 ml/kg of a 10% solution once a day for 7 day also expressed a significantly increased the intestinal transit and gastric emptying similarly to those of conventional succimer (60 mg/kg, i.g.), the standard sulfhydryl containing an antiulcer agent
through the restoration of antioxidant of serum GSH level.
However, such increase of intestinal transit induced by BTE was reversed both by N-omega-nitro-L-arginine methyl ester (L-NAME) (25 mg/kg, i.p.) and N-omega-monomethyl-L-arginine (L-NMMA) (25 mg/kg, i.p.), in reduced levels of NO in the aided stomach in the production of gastric acid for digestive function.
Dr. Maity S, the lead author said, "restoration of intestinal nitric oxide synthase (NOS) activity was found to be associated with BTE treatment" and "These results provide evidence that nitric oxide may play a role in BTE-mediated movement of intestinal motility changes and gastric emptying induced by DEM, IDA, and NEM".
Taken together, black tea with plenty of phytochemicals may be considered as a functional food in reducing the risk and treatment of dyspepsia.
However, the intake of tea supplements should be taken with exceptional care to prevent acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Black tea extract and its thearubigins relieve the sildenafil-induced delayed gut motility in mice: a possible role of nitric oxide by Murad HA1, Abdallah HM. (PubMed)
(2) Role of reduced glutathione and nitric oxide in the black tea extract-mediated protection against ulcerogen-induced changes in motility and gastric emptying in rats by Maity S1, Vedasiromoni JR, Chaudhuri L, Ganguly DK. (PubMed)
(3) Gastrointestinal transit during endotoxemia: the role of nitric oxide by Wirthlin DJ1, Cullen JJ, Spates ST, Conklin JL, Murray J, Caropreso DK, Ephgrave KS. (PubMed)
(4) Evaluation of diet and life style in the etiopathogenesis of Urdhwaga Amlapitta (non-ulcer dyspepsia) by Umapati C. Baragi and Mahesh Kumar Vyas. (PubMed)
Friday, October 18, 2019
Green Tea, The Potent Functional Beverage Which Protects Your Lung Against The Onset of Pneumonia, Medline Studies Find
Green tea may have a therapeutic and positive effect in inhibiting the onset of pneumonia, some scientists suggested.
Pneumonia is a lung infection caused by bacteria, viruses, or fungi. The disease may be contagious, as it can spread from person to person, depending on types of infectious pathogens.
However, pneumonia induced by fungal passed from the environment to humans is not contagious from person to person.
Bacteria Gram-positive cocci. Streptococcus pneumonia is the most cause of community-acquired pneumonia in adults and Haemophilus influenza is the second most common cause of bacterial pneumonia.
Additionally, people who have a weakened immune system, are hospitalized or being on a ventilator. and smoking is most likely to be infected with the disease.
Certain chronic medical conditions including asthma, chronic obstructive pulmonary disease, structural lung disease, and heart disease are found to associate with an increased risk of pneumonia.
The common symptoms include chest pain when you breathe or cough, persistent coughing, fatigue. fever, sweating and shaking chills. If you over the age of 50, you may also have the symptoms of confusion or changes in mental awareness'
According to the statistic, the disease affects over approximately 450 million people a year, in all parts of the world.
Green tea is a precious drink processed a number of health benefits known to almost everyone in Asia and the Western world.
In the investigation of green tea bioactive polyphenol catechins activity in the inhibition of infectious agents, researchers at the Tohoku University Graduate School of Medicine launched a population-based cohort study, with follow-up from 1995 to 2006, using the database of National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y).
Participants with missing reports of green tea consumption and a history of cancer, myocardial infarction, stroke, and extreme daily energy intake at baseline were excluded.
The comparison of green tea intake and the risk of death in patients with inflammatory pneumonia was analyzed according to the Cox proportional hazards regression analysis.
According to the review, after 12 years of follow up, researchers found that participants who drink <1, 1-2 cups/d, 3-4 and > or =5 cups/d expressed a reduced risk of the hazard of 1, 0.59, 0.55, 0.53, respectively.
These results indicated that green tea intake was associated with the significantly lower risk of death in patients with pneumonia.
Also, the results of the efficacy of green tea increased substantially and linearly to numbers of cup consumed per day.
Further analysis to confirm the inhibitory effects of tea polyphenols on Chlamydia trachomatis and C. pneumonia. In vitro, researchers at the Saitama Medical School, Iruma conducted an experiment of injection of tea polyphenols, Polyphenon 70S into Chlamydial strains including C. trachomatis D/UW-3/Cx and L(2)/434/Bu, and C. pneumonia AR-39 and AC-43 strains cultivated in cells and HL cells.
At the final phase of the experiment, researchers indicated that in the pre-inoculation method, the application of Polyphenon 70S Completely inhibits both straits without inducing any adverse effects.
However, in the post-inoculation method, injection of Polyphenon 70S at a dose of at 0.5 mg/ml demonstrated no inclusive effect against C. trachomatis but induced toxicity to HeLa229 cells and HL cells at a concentration of 0.25 mg/ml.
Additional differentiation concluded that the application of tea polyphenols may be considered as a potential topical usage.
Interestingly, in the study to clarify the in vitro effect of EGCG on C. pneumonia mediated IgE responses by peripheral blood mononuclear cells (PBMC) in asthma by using PBMC from subjects with asthma and non-asthmatic controls incubated with C. pneumonia and cultured for 10 days ±EGCG (0.5, 5.0, 50 ng/mL), with IgE levels of PBMC from non-asthmatics of <2.0 ng/mL) at baseline scientists showed that application of EGCG (0.5-50 ng/mL) displays a significant inhibitory effect of PBMC from the asthma patient, by suppressing the IgE production in a dose-dependent manner (10-30%), compared to no EGCG treatment group.
More importantly, injection of green tea EGCG exerted an insignificant effect against PBMC from non-asthmatics incubated with C. pneumoniae as the IgE levels are undetectable (<2.0 ng/mL).
These results suggest that green tea EGCG demonstrated a cell-protective activity against bacterial invasion through its cytotoxicity without causing harm to nearby healthy cells.
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in amelioration of the risk and treatment of pneumonia. Intake of green tea supplement should be taken with extreme care, as acute liver toxicity was reported in numbers of cases.
However, further data collection on large example size and multi-centers studies performed with human consumption of the beverage during the course of the disease will be necessary to complete the picture of green tea anti-pneumonia possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and death from pneumonia in Japan: the Ohsaki cohort study by Watanabe I1, Kuriyama S, Kakizaki M, Sone T, Ohmori-Matsuda K, Nakaya N, Hozawa A, Tsuji I.(PubMed)
(2) In vitro inhibitory effects of tea polyphenols on the proliferation of Chlamydia trachomatis and Chlamydia pneumoniae by Yamazaki T1, Inoue M, Sasaki N, Hagiwara T, Kishimoto T, Shiga S, Ogawa M, Hara Y, Matsumoto T.(PubMed)
(3) Epigallocatechin gallate suppresses Chlamydia pneumoniae mediated IgE responses in peripheral blood mononuclear cells: a pilot study by Smith-Norowitz TA1, Chotikanatis K, Tam E, Norowitz YM, Joks R, Durkin HG, Hammerschlag MR, Kohlhoff S.(PubMed)
(4) Protective effects of (-)-epigallocatechin-3-gallate against TNF-α-induced lung inflammation via ROS-dependent ICAM-1 inhibition by Lee IT1, Lin CC, Lee CY, Hsieh PW, Yang CM. (PubMed)
Pneumonia is a lung infection caused by bacteria, viruses, or fungi. The disease may be contagious, as it can spread from person to person, depending on types of infectious pathogens.
However, pneumonia induced by fungal passed from the environment to humans is not contagious from person to person.
Bacteria Gram-positive cocci. Streptococcus pneumonia is the most cause of community-acquired pneumonia in adults and Haemophilus influenza is the second most common cause of bacterial pneumonia.
Additionally, people who have a weakened immune system, are hospitalized or being on a ventilator. and smoking is most likely to be infected with the disease.
Certain chronic medical conditions including asthma, chronic obstructive pulmonary disease, structural lung disease, and heart disease are found to associate with an increased risk of pneumonia.
The common symptoms include chest pain when you breathe or cough, persistent coughing, fatigue. fever, sweating and shaking chills. If you over the age of 50, you may also have the symptoms of confusion or changes in mental awareness'
According to the statistic, the disease affects over approximately 450 million people a year, in all parts of the world.
Green tea is a precious drink processed a number of health benefits known to almost everyone in Asia and the Western world.
In the investigation of green tea bioactive polyphenol catechins activity in the inhibition of infectious agents, researchers at the Tohoku University Graduate School of Medicine launched a population-based cohort study, with follow-up from 1995 to 2006, using the database of National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y).
Participants with missing reports of green tea consumption and a history of cancer, myocardial infarction, stroke, and extreme daily energy intake at baseline were excluded.
The comparison of green tea intake and the risk of death in patients with inflammatory pneumonia was analyzed according to the Cox proportional hazards regression analysis.
According to the review, after 12 years of follow up, researchers found that participants who drink <1, 1-2 cups/d, 3-4 and > or =5 cups/d expressed a reduced risk of the hazard of 1, 0.59, 0.55, 0.53, respectively.
These results indicated that green tea intake was associated with the significantly lower risk of death in patients with pneumonia.
Also, the results of the efficacy of green tea increased substantially and linearly to numbers of cup consumed per day.
Further analysis to confirm the inhibitory effects of tea polyphenols on Chlamydia trachomatis and C. pneumonia. In vitro, researchers at the Saitama Medical School, Iruma conducted an experiment of injection of tea polyphenols, Polyphenon 70S into Chlamydial strains including C. trachomatis D/UW-3/Cx and L(2)/434/Bu, and C. pneumonia AR-39 and AC-43 strains cultivated in cells and HL cells.
At the final phase of the experiment, researchers indicated that in the pre-inoculation method, the application of Polyphenon 70S Completely inhibits both straits without inducing any adverse effects.
However, in the post-inoculation method, injection of Polyphenon 70S at a dose of at 0.5 mg/ml demonstrated no inclusive effect against C. trachomatis but induced toxicity to HeLa229 cells and HL cells at a concentration of 0.25 mg/ml.
Additional differentiation concluded that the application of tea polyphenols may be considered as a potential topical usage.
Interestingly, in the study to clarify the in vitro effect of EGCG on C. pneumonia mediated IgE responses by peripheral blood mononuclear cells (PBMC) in asthma by using PBMC from subjects with asthma and non-asthmatic controls incubated with C. pneumonia and cultured for 10 days ±EGCG (0.5, 5.0, 50 ng/mL), with IgE levels of PBMC from non-asthmatics of <2.0 ng/mL) at baseline scientists showed that application of EGCG (0.5-50 ng/mL) displays a significant inhibitory effect of PBMC from the asthma patient, by suppressing the IgE production in a dose-dependent manner (10-30%), compared to no EGCG treatment group.
More importantly, injection of green tea EGCG exerted an insignificant effect against PBMC from non-asthmatics incubated with C. pneumoniae as the IgE levels are undetectable (<2.0 ng/mL).
These results suggest that green tea EGCG demonstrated a cell-protective activity against bacterial invasion through its cytotoxicity without causing harm to nearby healthy cells.
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in amelioration of the risk and treatment of pneumonia. Intake of green tea supplement should be taken with extreme care, as acute liver toxicity was reported in numbers of cases.
However, further data collection on large example size and multi-centers studies performed with human consumption of the beverage during the course of the disease will be necessary to complete the picture of green tea anti-pneumonia possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and death from pneumonia in Japan: the Ohsaki cohort study by Watanabe I1, Kuriyama S, Kakizaki M, Sone T, Ohmori-Matsuda K, Nakaya N, Hozawa A, Tsuji I.(PubMed)
(2) In vitro inhibitory effects of tea polyphenols on the proliferation of Chlamydia trachomatis and Chlamydia pneumoniae by Yamazaki T1, Inoue M, Sasaki N, Hagiwara T, Kishimoto T, Shiga S, Ogawa M, Hara Y, Matsumoto T.(PubMed)
(3) Epigallocatechin gallate suppresses Chlamydia pneumoniae mediated IgE responses in peripheral blood mononuclear cells: a pilot study by Smith-Norowitz TA1, Chotikanatis K, Tam E, Norowitz YM, Joks R, Durkin HG, Hammerschlag MR, Kohlhoff S.(PubMed)
(4) Protective effects of (-)-epigallocatechin-3-gallate against TNF-α-induced lung inflammation via ROS-dependent ICAM-1 inhibition by Lee IT1, Lin CC, Lee CY, Hsieh PW, Yang CM. (PubMed)
Herbal Coltsfoot (Tussilago farfara), the Potent Antibacterial Antibiotic
The bacterial infection is the inflammation caused by the multiplication of bacterias after entering the body successfully.
The process of infection can be divided into many stages. However, most bacterias that try to invade the body were killed in the acute phase of infection by the immune system response through the production of the pro-inflammatory cytokines stimulated by the white blood cell macrophages.
According to the statistic provided by the CDC, each year in the U.S., at least 2 million people get an antibiotic-resistant infection, and at least 23,000 people die due to bacterial infectious disease.
Most people do not experience any symptoms until the microbe multiplication to the peak in its’ population.
Acute infection in most cases is recovered with a week or two. However, if the immune function cannot destroy all the bacterias within 3 to 8 weeks, it will compromise, leading to chronic low-grade inflammatory diseases.
Most common and classical symptoms of acute infection are aches, pains, fever, malaise, and nausea.
The chronic low-grade inflammatory state is a pathological feature of a wide range of chronic conditions, such as metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD), type 2 diabetes.
A most common risk of bacterial infection is a weakened immune system, particularly in the elderly.
The Institute of Medicine (US) Division of Health Promotion and Disease Prevention in examing the risk of infection in elderly, wrote, "The implications of an aging population for health care are being widely discussed but seldom with the understanding that health promotion and disability prevention are workable concepts for people in the “second 50” years of life".
And, "Pneumonia and influenza are among the leading causes of death and morbidity from infection among older people. Safe and effective vaccines to prevent pneumonia and influenza are available and should be universally used in persons over age 50. Nosocomial (institutionally acquired) infections have a major deleterious impact on persons over 50 and require good infection control practices in hospitals and nursing homes".
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belongings to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of bacterial infection, researchers examined the effect of the flower bud extract of Tussilago farfara on Gram-positive and Gram-negative bacteria.
The study is to compare the antibacterial activity of silver and gold nanoparticles of sesquiterpenoids from T. farfara flower bud extract and the use of extract alone.
According to the tested analysis, the silver nanoparticles exerted a two- to the four-fold enhancement of the extract comapred to the extract alone in the treatment of both Gram-positive and Gram-negative bacteria.
The solver nanoparticles also showed the highest antibacterial activity against vancomycin-resistant Enterococci Van-A type Enterococcus faecium, comapred to the extract alone.
Based on the findings, researchers said, " both nanoparticles synthesized with the sesquiterpenoids from T. farfara flower bud extract can be applied as drug delivery vehicles of anticancer or antibacterial agents for future nanomedicine applications.s".
Taken altogether, coltsfoot and silver and gold nanoparticles of sesquiterpenoids from T. farfara flower bud extract may be considered remedies for the treatment of bacterial infection, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemical composition and antibacterial activity of Tussilago farfara (L.) essential oil from Quebec, Canada by Boucher MA1, Côté H1, Pichette A1, Ripoll L1, Legault J. (PubMed)
(2) Sesquiterpenoids from Tussilago farfara Flower Bud Extract for the Eco-Friendly Synthesis of Silver and Gold Nanoparticles Possessing Antibacterial and Anticancer Activities by Lee YJ1, Song K2, Cha SH3, Cho S4, Kim YS5, Park Y. (PubMed)
(3) The Second Fifty Years by Promoting Health and Preventing Disability (1992). (NCBI)
The process of infection can be divided into many stages. However, most bacterias that try to invade the body were killed in the acute phase of infection by the immune system response through the production of the pro-inflammatory cytokines stimulated by the white blood cell macrophages.
According to the statistic provided by the CDC, each year in the U.S., at least 2 million people get an antibiotic-resistant infection, and at least 23,000 people die due to bacterial infectious disease.
Most people do not experience any symptoms until the microbe multiplication to the peak in its’ population.
Acute infection in most cases is recovered with a week or two. However, if the immune function cannot destroy all the bacterias within 3 to 8 weeks, it will compromise, leading to chronic low-grade inflammatory diseases.
Most common and classical symptoms of acute infection are aches, pains, fever, malaise, and nausea.
The chronic low-grade inflammatory state is a pathological feature of a wide range of chronic conditions, such as metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD), type 2 diabetes.
A most common risk of bacterial infection is a weakened immune system, particularly in the elderly.
The Institute of Medicine (US) Division of Health Promotion and Disease Prevention in examing the risk of infection in elderly, wrote, "The implications of an aging population for health care are being widely discussed but seldom with the understanding that health promotion and disability prevention are workable concepts for people in the “second 50” years of life".
And, "Pneumonia and influenza are among the leading causes of death and morbidity from infection among older people. Safe and effective vaccines to prevent pneumonia and influenza are available and should be universally used in persons over age 50. Nosocomial (institutionally acquired) infections have a major deleterious impact on persons over 50 and require good infection control practices in hospitals and nursing homes".
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belongings to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of bacterial infection, researchers examined the effect of the flower bud extract of Tussilago farfara on Gram-positive and Gram-negative bacteria.
The study is to compare the antibacterial activity of silver and gold nanoparticles of sesquiterpenoids from T. farfara flower bud extract and the use of extract alone.
According to the tested analysis, the silver nanoparticles exerted a two- to the four-fold enhancement of the extract comapred to the extract alone in the treatment of both Gram-positive and Gram-negative bacteria.
The solver nanoparticles also showed the highest antibacterial activity against vancomycin-resistant Enterococci Van-A type Enterococcus faecium, comapred to the extract alone.
Based on the findings, researchers said, " both nanoparticles synthesized with the sesquiterpenoids from T. farfara flower bud extract can be applied as drug delivery vehicles of anticancer or antibacterial agents for future nanomedicine applications.s".
Taken altogether, coltsfoot and silver and gold nanoparticles of sesquiterpenoids from T. farfara flower bud extract may be considered remedies for the treatment of bacterial infection, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemical composition and antibacterial activity of Tussilago farfara (L.) essential oil from Quebec, Canada by Boucher MA1, Côté H1, Pichette A1, Ripoll L1, Legault J. (PubMed)
(2) Sesquiterpenoids from Tussilago farfara Flower Bud Extract for the Eco-Friendly Synthesis of Silver and Gold Nanoparticles Possessing Antibacterial and Anticancer Activities by Lee YJ1, Song K2, Cha SH3, Cho S4, Kim YS5, Park Y. (PubMed)
(3) The Second Fifty Years by Promoting Health and Preventing Disability (1992). (NCBI)
Thursday, October 17, 2019
Healthy Food Onion in the Inhibition of Angiogenesis
Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.
In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.
Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumors proliferation and metastasis.
More precisely, the angiogenesis process a function of a double sword, on one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.
Dr. Papetti M continued, "tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"
Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".
Based on the findings some researchers suggested, by inhibiting the process of blood vessels formation of the tumor, cancer may be curable.
Dr. Dai X, the lead researchers in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibits tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potent ingredient that processes anti-cancer activity researchers studied the antiangiogenic activity of quercetin isolated from onion, using ex vivo, in vivo and in vitro models.
According to the tested differentiation, quercetin at non-toxic concentrations significantly inhibited the microvessel sprouting associated with cancer cell proliferation.
Furthermore, the activity of cancer cells migration, invasion and tube formation of endothelial cells involved in the process of angiogenesis.was also significantly decreased by the administration of quercetin.
Quercetin treatment inhibited ex vivo angiogenesis observed by chicken egg chorioallantoic membrane assay (CAM) and matrigel plug assay.
Moreover, quercetin suppressed vascular endothelial growth factor (VEGF) which has been found to induce the formation of a blood vessel for the progression of the tumor.
Additionally, downstream pathways associated with the promotion of survival and growth in response to extracellular signals that induce angiogenesis were also inhibited by quercetin in HUVECs.
Quercetin at the concentration of 20 mg/kg/d significantly reduced the volume and the weight of solid tumors in a prostate xenograft mouse model by targeting angiogenesis.
Quercetin was also found to inhibited the cancer cell viability and induced apoptosis in prostate cancer cells.
In other words, quercetin inhibits tumor growth and angiogenesis by targeting the proteins and signaling pathways that initiate the growth of new blood vessels.
Taken altogether, onion processed a higher mount of quercetin may be considered a remedy for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways by Poyil Pratheeshkumar, Amit Budhraja, Young-Ok Son, Xin Wang, Zhuo Zhang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Mei Xu, Gang Chen, Jia Luo, and Xianglin Shi. (Plos One)
(2) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Dai X1,2, Jiang P2, Ji Y3, Zhu X2, Sun X. (PubMed)
In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.
Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumors proliferation and metastasis.
More precisely, the angiogenesis process a function of a double sword, on one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.
Dr. Papetti M continued, "tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"
Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".
Based on the findings some researchers suggested, by inhibiting the process of blood vessels formation of the tumor, cancer may be curable.
Dr. Dai X, the lead researchers in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibits tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potent ingredient that processes anti-cancer activity researchers studied the antiangiogenic activity of quercetin isolated from onion, using ex vivo, in vivo and in vitro models.
According to the tested differentiation, quercetin at non-toxic concentrations significantly inhibited the microvessel sprouting associated with cancer cell proliferation.
Furthermore, the activity of cancer cells migration, invasion and tube formation of endothelial cells involved in the process of angiogenesis.was also significantly decreased by the administration of quercetin.
Quercetin treatment inhibited ex vivo angiogenesis observed by chicken egg chorioallantoic membrane assay (CAM) and matrigel plug assay.
Moreover, quercetin suppressed vascular endothelial growth factor (VEGF) which has been found to induce the formation of a blood vessel for the progression of the tumor.
Additionally, downstream pathways associated with the promotion of survival and growth in response to extracellular signals that induce angiogenesis were also inhibited by quercetin in HUVECs.
Quercetin at the concentration of 20 mg/kg/d significantly reduced the volume and the weight of solid tumors in a prostate xenograft mouse model by targeting angiogenesis.
Quercetin was also found to inhibited the cancer cell viability and induced apoptosis in prostate cancer cells.
In other words, quercetin inhibits tumor growth and angiogenesis by targeting the proteins and signaling pathways that initiate the growth of new blood vessels.
Taken altogether, onion processed a higher mount of quercetin may be considered a remedy for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways by Poyil Pratheeshkumar, Amit Budhraja, Young-Ok Son, Xin Wang, Zhuo Zhang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Mei Xu, Gang Chen, Jia Luo, and Xianglin Shi. (Plos One)
(2) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Dai X1,2, Jiang P2, Ji Y3, Zhu X2, Sun X. (PubMed)
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