Tropical pancreatitis is a special medical condition of chronic pancreatitis found mainly in tropical countries.
According to the Indian statistics, the prevalence of tropical pancreatitis is about 126/100,000 population in southern India involved mostly in the pancreatic duct in the younger population.
Recently, the disease has been found to increase at an alarming rate in the older population in Southern Indian, due to excessive alcohol consumption and smoking.
Some researchers suggested that dietetic, environmental and socioeconomic factors change over the years, that cause the environment-gene interactions may increase the risk of the onset of the disease.
In other words, diet change from a traditional diet to a high-fat diet, malnutrition, medical condition such as infection and weakened immunity and excessive alcoholism and smoking has been found to facilitate the gene mutation such as SPINK1 in older adults with tropical pancreatitis in the tropical region.
Clinically, symptoms of patients with tropical pancreatitis are severe abdominal pain, leading to the onset of diabetes in 25% of patients who require daily insulin injection.
As of today, there is no cure for the disease. Conventional medicines used for the treatment are focusing on reduced symptoms of pain and improve quality of life.
Dr. Tandon RK, the lead scientist said, " Endotherapy coupled with stone fragmentation by extracorporeal shock wave lithotripsy is an effective therapy for those who fail to respond to medical therapy".
And, "Surgical decompression of the main pancreatic duct by lateral pancreaticojejunostomy is reserved for patients with severe pain non-responsive to other forms of therapy".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a new compound for the treatment of pancreatitis, scientists examined the effect of oral curcumin with piperine on the pain and the markers of oxidative stress in patients with tropical pancreatitis (TP).
The experiment included 20 consecutive patients with tropical pancreatitis randomized to receive 500 mg of curcumin with 5 mg of piperine or placebo for 6 weeks.
The pattern of pain, and on red blood cell levels of malonyldialdehyde (MDA), oxidative stress marker and glutathione (GSH), the antioxidant enzymes produced by the patients were assessed before and after at the end of the study.
Compared to the placebo, patients received 500 mg of curcumin with 5 mg of piperine displayed a significant reduction in oxidative stress observed by the erythrocyte MDA and increased GSH levels.
However, injection of 500 mg of curcumin with 5 mg of piperine did not reduce the pain score.
In other words, oral curcumin with piperine reversed lipid peroxidation in patients with tropical pancreatitis by increasing the production of antioxidant enzymes and inhibiting free radical expression.
Based on the findings, researchers suggested before the composite is used for the treatment of tropical pancreatitis, the effect on the pain and other manifestations of tropical pancreatitis must be reassessed.
Taken altogether, turmeric combined with piperine may be considered supplements for the prevention and treatment of tropical pancreatitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A pilot study of the antioxidant effect of curcumin in tropical pancreatitis by Durgaprasad S1, Pai CG, Vasanthkumar, Alvres JF, Namitha S. (PubMed)
(2) Tropical pancreatitis by Tandon RK1, Garg PK. (PubMed)
Friday, October 25, 2019
Green Tea, The Potent Functional Beverage Inhibits the Pathogens That Cause Pneumonia, Scientists Say
Green tea may have a therapeutic and positive effect in reducing the risk and progression and treatment of pneumonia, some scientists suggested.
Pneumonia is a lung infection caused by bacteria, viruses, or fungi. Bacterial pneumonia is the most common type in adults.
Researchers do not know why people with the same health condition, are susceptible to the onset of the disease while others do not.
However, according to the studies, certain groups of people are at a higher prevalent risk, including babies and toddlers, who have an immature immune system, people who have had a recent viral infection and people with chronic lung conditions such as asthma, bronchitis or bronchiectasis.
Additionally, people with suppressed immune systems, excessive alcohol drinking and smoking habit and the elderly are also associated with the increased risk of lung infection.
Most common symptoms include fever and chill caused overexpression of inflammatory cytokines, shortness of breath and increased breathing rate, caused by reduced lung function.
Some patients with pneumonia also have serious symptoms of persistent coughing with phlegm, that does not disappear itself and chest pain.
If you experience some of the above symptoms, you may have pneumonia. Please check with your doctor to rule out the possibility.
Green tea is a precious drink processed number of health benefits and known to almost everyone in Asia and the Western world.
In a population-based cohort study, with the follow-up from 1995 to 2006 conducted by Tohoku University Graduate School of Medicine using data of participants in National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y), researchers wrote at the end of the experiment,
* Over 12 y of follow-up, 406 deaths from pneumonia, according to the reported documents.
* According to the hazard ratios (HRs), injection of green tea demonstrated a significant reduction of death from pneumonia, (<1 cup/d, HRs
Injection of green tea <1 cup/d, with HRs of 1, 1-2 cups/d with HRs of 0.59, 3-4 cups/d, HRs of 0.55 and > or =5 cups/d with Hrs of .53, respectively in women.
Interestingly, in men, green tea injection regardless of volumes display no significant association in the risk of death from pneumonia.
These results suggested that green tea intake daily and regularly may have a strong effect in reducing risk, progression, treatment of lung infection, particularly, in the reduced rate of motility in women.
Furthermore, in the evaluate epigallocatechin gallate (EGCG) effect in influenza A virus in the induction of pneumonia in Madin-Darby canine kidney (MDCK) cells of BALB/c mice treated with EGCG (10, 20 or 40 mg·kg(-1)·d(-1), po) for 5 days. and on the 3rd day of the treatment, the mice were infected with influenza A virus., researcher indicated that
* EGCG treatment group exerts a significant inhibition of the expression of influenza A virus in elevating the production of reactive oxygen species.
* EGCG also inhibits the influenza A replication at a concentration-dependent manner (the ED(50) value of 8.71±1.11 nmol/L).
* Importantly, oral administration of green tea EGCG dramatically improves the survival rate, decreases the mean virus yields and mitigates viral pneumonia in the lungs, compared to conventional medicine at oseltamivir (40 mg·kg(-1)·d(-1)).
These results were supported by the investigation to examine, whether green tea by-products could function as an alternative to common antivirals in animals, conducted by the Konkuk University.
According to the experiment, both applications demonstrated a significantly inhibited influenza activity with green tea by-products (EC₅₀ = 6.36 µg/mL) to be equivalent to that of original green tea (EC₅₀= 6.72 µg/mL
In against the H1N1 virus A/NWS/33, the anti-influenza activity of green tea by-products (EC₅₀ = 6.36 µg/mL) is equivalent to that of original green tea (EC₅₀= 6.72 µg/mL).
However, in tested mice, oral administration of green tea by-products reduced viral titers in the lungs in the early phase of infection, but they could not protect these animals from disease and death compared to therapeutic administration of green tea by-products via feed or water supplement on a dose-dependent manner and the rate of motility at dose of 10 g/kg of feed.
These results unsurprisingly suggested that green tea bioactive compounds as a single ingredient consist of a strong effect in reducing the death of pneumonia pathogens compared to the intake of green tea whole foods.
After taking into account other co and confounders, Dr. Lee HJ said, "Unidentified hexane-soluble fractions of green tea by-products possessed strong anti-influenza activity, in addition to ethyl acetate-soluble fractions, including catechins".
Taken together, green tea and its bioactive polyphenols catechin may be considered as functional foods in reducing risk, progression and treatment of pneumonia, particularly in the decrease of death ratio.
However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity has been reported in numbers of the case.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and death from pneumonia in Japan: the Ohsaki cohort study by Watanabe I1, Kuriyama S, Kakizaki M, Sone T, Ohmori-Matsuda K, Nakaya N, Hozawa A, Tsuji I.(PubMed)
(2) Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea by Ling JX1, Wei F, Li N, Li JL, Chen LJ, Liu YY, Luo F, Xiong HR, Hou W, Yang ZQ.(PubMed)
(3) Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens by Lee HJ1, Lee YN, Youn HN, Lee DH, Kwak JH, Seong BL, Lee JB, Park SY, Choi IS, Song CS(PubMed).
Pneumonia is a lung infection caused by bacteria, viruses, or fungi. Bacterial pneumonia is the most common type in adults.
Researchers do not know why people with the same health condition, are susceptible to the onset of the disease while others do not.
However, according to the studies, certain groups of people are at a higher prevalent risk, including babies and toddlers, who have an immature immune system, people who have had a recent viral infection and people with chronic lung conditions such as asthma, bronchitis or bronchiectasis.
Additionally, people with suppressed immune systems, excessive alcohol drinking and smoking habit and the elderly are also associated with the increased risk of lung infection.
Most common symptoms include fever and chill caused overexpression of inflammatory cytokines, shortness of breath and increased breathing rate, caused by reduced lung function.
Some patients with pneumonia also have serious symptoms of persistent coughing with phlegm, that does not disappear itself and chest pain.
If you experience some of the above symptoms, you may have pneumonia. Please check with your doctor to rule out the possibility.
Green tea is a precious drink processed number of health benefits and known to almost everyone in Asia and the Western world.
In a population-based cohort study, with the follow-up from 1995 to 2006 conducted by Tohoku University Graduate School of Medicine using data of participants in National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y), researchers wrote at the end of the experiment,
* Over 12 y of follow-up, 406 deaths from pneumonia, according to the reported documents.
* According to the hazard ratios (HRs), injection of green tea demonstrated a significant reduction of death from pneumonia, (<1 cup/d, HRs
Injection of green tea <1 cup/d, with HRs of 1, 1-2 cups/d with HRs of 0.59, 3-4 cups/d, HRs of 0.55 and > or =5 cups/d with Hrs of .53, respectively in women.
Interestingly, in men, green tea injection regardless of volumes display no significant association in the risk of death from pneumonia.
These results suggested that green tea intake daily and regularly may have a strong effect in reducing risk, progression, treatment of lung infection, particularly, in the reduced rate of motility in women.
Furthermore, in the evaluate epigallocatechin gallate (EGCG) effect in influenza A virus in the induction of pneumonia in Madin-Darby canine kidney (MDCK) cells of BALB/c mice treated with EGCG (10, 20 or 40 mg·kg(-1)·d(-1), po) for 5 days. and on the 3rd day of the treatment, the mice were infected with influenza A virus., researcher indicated that
* EGCG treatment group exerts a significant inhibition of the expression of influenza A virus in elevating the production of reactive oxygen species.
* EGCG also inhibits the influenza A replication at a concentration-dependent manner (the ED(50) value of 8.71±1.11 nmol/L).
* Importantly, oral administration of green tea EGCG dramatically improves the survival rate, decreases the mean virus yields and mitigates viral pneumonia in the lungs, compared to conventional medicine at oseltamivir (40 mg·kg(-1)·d(-1)).
These results were supported by the investigation to examine, whether green tea by-products could function as an alternative to common antivirals in animals, conducted by the Konkuk University.
According to the experiment, both applications demonstrated a significantly inhibited influenza activity with green tea by-products (EC₅₀ = 6.36 µg/mL) to be equivalent to that of original green tea (EC₅₀= 6.72 µg/mL
In against the H1N1 virus A/NWS/33, the anti-influenza activity of green tea by-products (EC₅₀ = 6.36 µg/mL) is equivalent to that of original green tea (EC₅₀= 6.72 µg/mL).
However, in tested mice, oral administration of green tea by-products reduced viral titers in the lungs in the early phase of infection, but they could not protect these animals from disease and death compared to therapeutic administration of green tea by-products via feed or water supplement on a dose-dependent manner and the rate of motility at dose of 10 g/kg of feed.
These results unsurprisingly suggested that green tea bioactive compounds as a single ingredient consist of a strong effect in reducing the death of pneumonia pathogens compared to the intake of green tea whole foods.
After taking into account other co and confounders, Dr. Lee HJ said, "Unidentified hexane-soluble fractions of green tea by-products possessed strong anti-influenza activity, in addition to ethyl acetate-soluble fractions, including catechins".
Taken together, green tea and its bioactive polyphenols catechin may be considered as functional foods in reducing risk, progression and treatment of pneumonia, particularly in the decrease of death ratio.
However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity has been reported in numbers of the case.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and death from pneumonia in Japan: the Ohsaki cohort study by Watanabe I1, Kuriyama S, Kakizaki M, Sone T, Ohmori-Matsuda K, Nakaya N, Hozawa A, Tsuji I.(PubMed)
(2) Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea by Ling JX1, Wei F, Li N, Li JL, Chen LJ, Liu YY, Luo F, Xiong HR, Hou W, Yang ZQ.(PubMed)
(3) Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens by Lee HJ1, Lee YN, Youn HN, Lee DH, Kwak JH, Seong BL, Lee JB, Park SY, Choi IS, Song CS(PubMed).
Thursday, October 24, 2019
Green Tea, the Beverage May Speeds Up the Healing of Chronic Back Pain
Green tea may have a therapeutic and positive effect in ameliorated symptoms and treatment of chronic back pain, some scientists suggested.
Chronic back pain is a condition of musculoskeletal disorders(MSDs) of the spine that lasts more than 3 months, caused by various factors, including bone fractures, muscle or ligament injury, arthritis, herniated discs. aging,...
Certain symptoms are associated with patients with chronic back pain, including loss of bowel or bladder control if the condition is on the lower back, numbness, tingling, or weakness in one or both legs and constant pain that gets worse at night.
According to the statistic provided by the Australian Institute of Health and Welfare,
* In 2014–15, an estimated 3.7 million Australians (16%, or 1 in 6 people) had chronic back problems.
* The prevalence of the condition increases with age up to before declining slightly in aged 75 and over.
*More than three-quarters (77%) of people with chronic back problems were of working age (15–64), and
* In 2008–09, around 1.8% of total health-care expenditure in Australia ($1.2 billion) was attributed to back problems, causing a significant burden to the economy in the country.
Some researchers in the finding of mutated genes which have strong influence in the onset of chronic back pain suggested, " ...only a minority of the genetic influences was caused by genes affecting disc degeneration suggesting that genes involved in pain perception, signaling, and psychological processing (Foulkes and Wood 2008), and genetic variants of immune genes (Solovieva et al. 2004b) contribute to the proportion of heritability of chronic back pain".
These results indicated that genetic mutation inherited from the parent may have a minor effect in contributing to the early development of the condition.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through facilitating the anti-inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in the induction of back pain.
According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributing the inflammatory pain hypersensitivity in the site of infection observed by the reverse transcription polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.
Furthermore, the application also displayed a strong effect on reducing expression of
p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.
Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.
Moreover, in the radiculopathy pain component, researchers also indicated that EGCG inhibited the inflammation in the precipitated back pain through modulating the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in response to stress stimuli.
Some researchers indicated that back pain may also be induced by muscle degeneration and impairment nerve injury, leading to increased levels of reactive oxygen species in the induction of tissue apoptosis.
In crushing of the sciatic nerve induced back pain in a tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gained in the percentage motor deficit.
More importantly, EGCG expressed a significant effect on the recovery of sensory innervation in neuropathic pain-like syndrome and improved muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.
According to the RT-PCR assay, EGCG treatment also normalized the Bax/Bcl-2 ratio, the abnormal ratio of the Bax/Bcl-2 ratio has been found to associate with the induction of nerve cell apoptosis as well as inhibiting levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.
These results demonstrated an important effect of green tea EGCG in the enhanced functional recovery, by protecting muscle fibers from cellular death, and improving morphological recovery in the skeletal muscle after nerve injuries.
However, in the study of caffeine activity in the modulation of pain perception in chronic pain states of 131 patients with chronic low back pain (64 men and 67 women; mean age = 42.1 years; mean duration of pain = 6.1 years) referred to a multidisciplinary pain clinic over a 2-year period, researchers found that caffeine is not related to the global experience of pain and disability in patients with chronic low back pain, although high caffeine use may be embedded in the context of other unhealthy lifestyle behaviors.
Taken all together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered functional foods in reduced back pain caused by physical damage of the spine and injured nerve cells.
Intake of green tea supplement should be taken with exceptional care as some cases of liver acute toxicity have been reported in the medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST. (PubMed)
(4) Genetic Factors Modulating Chronic Back Pain by Julia Metzner and Irmgard Tegeder
Chronic back pain is a condition of musculoskeletal disorders(MSDs) of the spine that lasts more than 3 months, caused by various factors, including bone fractures, muscle or ligament injury, arthritis, herniated discs. aging,...
Certain symptoms are associated with patients with chronic back pain, including loss of bowel or bladder control if the condition is on the lower back, numbness, tingling, or weakness in one or both legs and constant pain that gets worse at night.
According to the statistic provided by the Australian Institute of Health and Welfare,
* In 2014–15, an estimated 3.7 million Australians (16%, or 1 in 6 people) had chronic back problems.
* The prevalence of the condition increases with age up to before declining slightly in aged 75 and over.
*More than three-quarters (77%) of people with chronic back problems were of working age (15–64), and
* In 2008–09, around 1.8% of total health-care expenditure in Australia ($1.2 billion) was attributed to back problems, causing a significant burden to the economy in the country.
Some researchers in the finding of mutated genes which have strong influence in the onset of chronic back pain suggested, " ...only a minority of the genetic influences was caused by genes affecting disc degeneration suggesting that genes involved in pain perception, signaling, and psychological processing (Foulkes and Wood 2008), and genetic variants of immune genes (Solovieva et al. 2004b) contribute to the proportion of heritability of chronic back pain".
These results indicated that genetic mutation inherited from the parent may have a minor effect in contributing to the early development of the condition.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Application of biologically active polyphenol epigallocatechin 3-gallate (EGCG) demonstrated a significant effect in reduced back pain through facilitating the anti-inflammatory and anti-catabolic activity in patients with intervertebral disc (IVD) disease due to age-related changes in the adult disc in the induction of back pain.
According to the study by the Institute for Biomechanics (D-HEST), ETH Zurich ingestion of green tea EGCG on back pain patients, human IVD cells isolated from patients undergoing surgery due to degenerative disc disease (n = 34) and cultured in 2D or 3D indicated that the phytochemical inhibited levels of inflammatory response activated by IL-1β, a cytokine protein produced by macrophages, with function in contributing the inflammatory pain hypersensitivity in the site of infection observed by the reverse transcription polymerase chain reaction (qRT-PCR), western blotting, enzyme-linked immunosorbent assay (ELISA), immunofluorescence and transcription factor assay.
Furthermore, the application also displayed a strong effect on reducing expression of
p38 mitogen-activated protein kinases in mediated inflammatory factors of IL-1β in responded to stress stimuli.
Also, according to the Institute for Biomechanics (D-HEST), in the investigation of the analgesic properties of EGCG, by the von Frey filament test in Sprague-Dawley rats (n = 60), green tea EGCG injection also significantly inhibited the expression of pro-inflammatory mediators as expressed in above and reduced matrix metalloproteinases which have been found to associate to pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.
Moreover, in the radiculopathy pain component, researchers also indicated that EGCG inhibited the inflammation in the precipitated back pain through modulating the activity of IRAK-1 in glucose metabolism and insulin sensitivity in skeletal muscle and p38, c-Jun N-terminal kinases (JNK) and nuclear factor NF-κB in response to stress stimuli.
Some researchers indicated that back pain may also be induced by muscle degeneration and impairment nerve injury, leading to increased levels of reactive oxygen species in the induction of tissue apoptosis.
In crushing of the sciatic nerve induced back pain in a tested animal, application of green tea EGCG improved motor function in the toe spread and foot positioning and gained in the percentage motor deficit.
More importantly, EGCG expressed a significant effect on the recovery of sensory innervation in neuropathic pain-like syndrome and improved muscle tissues from injured limb with severe histopathological alterations at the end of week 3 post-surgery in treated animals.
According to the RT-PCR assay, EGCG treatment also normalized the Bax/Bcl-2 ratio, the abnormal ratio of the Bax/Bcl-2 ratio has been found to associate with the induction of nerve cell apoptosis as well as inhibiting levels of p53 with function in regulated the cell death cycle at days 3 and 7 post-surgery.
These results demonstrated an important effect of green tea EGCG in the enhanced functional recovery, by protecting muscle fibers from cellular death, and improving morphological recovery in the skeletal muscle after nerve injuries.
However, in the study of caffeine activity in the modulation of pain perception in chronic pain states of 131 patients with chronic low back pain (64 men and 67 women; mean age = 42.1 years; mean duration of pain = 6.1 years) referred to a multidisciplinary pain clinic over a 2-year period, researchers found that caffeine is not related to the global experience of pain and disability in patients with chronic low back pain, although high caffeine use may be embedded in the context of other unhealthy lifestyle behaviors.
Taken all together, green tea and its bioactive component epigallocatechin 3-gallate (EGCG) may be considered functional foods in reduced back pain caused by physical damage of the spine and injured nerve cells.
Intake of green tea supplement should be taken with exceptional care as some cases of liver acute toxicity have been reported in the medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin 3-gallate suppresses interleukin-1β-induced inflammatory responses in intervertebral disc cells in vitro and reduces radiculopathic pain in rats by Krupkova O1, Sekiguchi M, Klasen J, Hausmann O, Konno S, Ferguson SJ, Wuertz-Kozak K.(PubMed)
(2) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A.(PubMed)
(3) Caffeine and chronic low back pain by Currie SR1, Wilson KG, Gauthier ST. (PubMed)
(4) Genetic Factors Modulating Chronic Back Pain by Julia Metzner and Irmgard Tegeder
Navy Bean Inhibits the Onset and Progression of Diseases Associated with Acute-Inflammation in Vivo
Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.
Acute inflammation is a short-term condition caused by tissue injury, leading to pain, redness, swelling, and heat to the affected area. depending on the size of the injury. Some patients with acute inflammation may also experience the symptom of loss of function.
In acute inflammation, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of platelets to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.
Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.
However, people with the weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.
Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.
Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin) and other prescription NSAIDs.
Holistically, according to the Medical University Innsbruck, the top 5 anti-inflammatory foods are
* Garlic
Recent studies also showed that garlic exhibits its anti-inflammatory effects against chronic inflammatory disease through phytochemical allicin and other mechanisms.
* Ginger
Strong evidence in Western studies suggested that ginger processes anti-inflammatory, antioxidant and immune-modulatory effects.
* Turmeric
Epidemiological studies also found that the efficacy of turmeric for the treatment of diabetes, microbial infection gastrointestinal diseases and irregular cell growth such as cancer through its anti-inflammatory antioxidant and immunomodulatory activities.
* Green tea
Epidemiological studies suggested that green tea consists of many pharmaceutical properties, including anti-cancer, anti-diabetes, anti-allergy, anti-micro-organisms infection, through its antioxidant, anti-inflammatory and immune-modulatory activities.
* Shiitake mushrooms
Recent studies showed that Shiitake mushrooms process the properties of anti-cancer, anti-HIV and hepatitis virus, an enhanced immune system against inflammation.
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
With an aim to find a potential ingredient for diseases associated with acute inflammation, researchers examined the enriched levels of nondigestible fermentable carbohydrates and phenolic compounds found in black and navy beans immunomodulatory effects on severity of colitis-associated inflammatory pathology.
In an animal model, C57Bl/6 mice were pre-fed isocaloric 20% cooked navy bean (NB) or black bean (BB) diets for 3 weeks and switched to control basal diet (BD) 24 h prior to colitis induction via 5-day exposure to dextran sodium sulfate (2% w/v in drinking water)+3 days of fresh water, researchers found that* The severity of the acute colitis phenotype associated with inflammation was inhibited by bean prefeeding, observed by reduced colon tissue inflammatory transcription factor activation such as NFκB, STAT3) and inflammatory mediator levels such as IL-1β, IL-6, IL-18 and MCP-1 compared to control.
* Black and navy beans also stimulated the biomarkers that enhance wound repair responses. including colon tissue protein levels of IL-22, IL-27.
* Furthermore, black and navy beans diet also increases the mRNA expressions of genes involved in the normal colonic epithelial function and the promotion of epithelial barrier integrity, defense and/or restitution and wound closure in acute colonic inflammation.
Based on the findings, researchers concluded, " bean supplementation prior to colitis induction (i.e., mimicking disease relapse) primes the colonic microenvironment to attenuate the severity of the colitis inflammatory phenotype and maintain aspects of epithelial barrier function".
Taken altogether, navy bean may be considered a remedy for the prevention and treatment of acute inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) (1) Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage by Monk JM1, Wu W2, Hutchinson AL3, Pauls P4, Robinson LE3, Power KA. (PMC)
(2) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA. (PubMed)
Acute inflammation is a short-term condition caused by tissue injury, leading to pain, redness, swelling, and heat to the affected area. depending on the size of the injury. Some patients with acute inflammation may also experience the symptom of loss of function.
In acute inflammation, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of platelets to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.
Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.
However, people with the weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.
Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.
Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin) and other prescription NSAIDs.
Holistically, according to the Medical University Innsbruck, the top 5 anti-inflammatory foods are
* Garlic
Recent studies also showed that garlic exhibits its anti-inflammatory effects against chronic inflammatory disease through phytochemical allicin and other mechanisms.
* Ginger
Strong evidence in Western studies suggested that ginger processes anti-inflammatory, antioxidant and immune-modulatory effects.
* Turmeric
Epidemiological studies also found that the efficacy of turmeric for the treatment of diabetes, microbial infection gastrointestinal diseases and irregular cell growth such as cancer through its anti-inflammatory antioxidant and immunomodulatory activities.
* Green tea
Epidemiological studies suggested that green tea consists of many pharmaceutical properties, including anti-cancer, anti-diabetes, anti-allergy, anti-micro-organisms infection, through its antioxidant, anti-inflammatory and immune-modulatory activities.
* Shiitake mushrooms
Recent studies showed that Shiitake mushrooms process the properties of anti-cancer, anti-HIV and hepatitis virus, an enhanced immune system against inflammation.
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
With an aim to find a potential ingredient for diseases associated with acute inflammation, researchers examined the enriched levels of nondigestible fermentable carbohydrates and phenolic compounds found in black and navy beans immunomodulatory effects on severity of colitis-associated inflammatory pathology.
In an animal model, C57Bl/6 mice were pre-fed isocaloric 20% cooked navy bean (NB) or black bean (BB) diets for 3 weeks and switched to control basal diet (BD) 24 h prior to colitis induction via 5-day exposure to dextran sodium sulfate (2% w/v in drinking water)+3 days of fresh water, researchers found that* The severity of the acute colitis phenotype associated with inflammation was inhibited by bean prefeeding, observed by reduced colon tissue inflammatory transcription factor activation such as NFκB, STAT3) and inflammatory mediator levels such as IL-1β, IL-6, IL-18 and MCP-1 compared to control.
* Black and navy beans also stimulated the biomarkers that enhance wound repair responses. including colon tissue protein levels of IL-22, IL-27.
* Furthermore, black and navy beans diet also increases the mRNA expressions of genes involved in the normal colonic epithelial function and the promotion of epithelial barrier integrity, defense and/or restitution and wound closure in acute colonic inflammation.
Based on the findings, researchers concluded, " bean supplementation prior to colitis induction (i.e., mimicking disease relapse) primes the colonic microenvironment to attenuate the severity of the colitis inflammatory phenotype and maintain aspects of epithelial barrier function".
Taken altogether, navy bean may be considered a remedy for the prevention and treatment of acute inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) (1) Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage by Monk JM1, Wu W2, Hutchinson AL3, Pauls P4, Robinson LE3, Power KA. (PMC)
(2) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA. (PubMed)
Wednesday, October 23, 2019
Green Tea and Its Bioactive Polyphenols Inhibit Alpha1-Antitrypsin (AAT) Deficiency Against the Onset of Fibromyalgia
Green tea may have a therapeutic and positive effect on reducing onset. progression and treatment of Alpha1-Antitrypsin (AAT) deficiency in the induced fibromyalgia, some scientists suggested.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in the US alone.
Serum of alpha1-Antitrypsin (AAT) impregnated in most parts of the body circulates in our body in high concentrations with function in the inhibition of the enzymes of inflammatory cells.
Alpha1-Antitrypsin (AAT) deficiency is a genetic disorder inherited from the parent characterized by of the inability of the body to produce a protein called alpha-1 anti-trypsin (AAT), leading to inflammation of fatty tissue under the skin (subcutaneous), and at other parts of the body, including the joints, the major cause of fibromyalgia.
Additionally, deficiency of AAT enynes also can cause liver and lung damage, leading to poor function of the organ and increasing the risk of cirrhosis, COPD, liver and lung cancer.
Although the deficiency is presented since birth, most patients with the mutated gene do not experience any symptoms until the age of 50 or 60.
According to the statistic, AAT deficiency is one of the most common inherited disorders among Caucasians compared to other race groups.
Approximately over 1% of patients diagnosed with chronic obstructive pulmonary disease (COPD) processes the alpha1-antitrypsin deficiency gene
In the study of the effect of serum of alpha1-Antitrypsin (AAT) and risk of fibromyalgia (FM), researchers at the Hospital Valle del Nalón found that deficiency of AAT has been found in numbers of patients with fibromyalgia (FM) with severe hereditary.
Functional magnetic resonance imaging of these patients revealed significantly greater activity in pain-sensitive areas of the brain in response to cutaneous stimuli, which may be another evidence for a physiological explanation for FM pain.
Furthermore, patients with FM also were found to consist of abnormal profiles of inflammation markers in biopsies analysis.
The results suggested that these patients may have an imbalance level of pro-inflammatory and anti-inflammatory substances, in the soft body tissues caused by alpha1-Antitrypsin (AAT) deficiency.
Due to surprising findings, Dr. Blanco LE, the lead author, after taking into account of other confounders, said, "identification of genetic, familial, and environmental risk factors suspected to participate in the FM syndrome development (may be necessary) to determine the gene frequency of AAT deficiency alleles in FM patients".
Green tea, bioactive polyphenols EGCG, according to the Dr Helieh S in animal model induced by alpha1-Antitrypsin (AAT) (α1-antitrypsin) deficiency exerted a significant anti-inflammatory effect in inhibited the PI3K/Akt signalling pathway with function in activated pro-inflammatory factors through the innate immune response involved in pathogen killing, antigen processing and immune cell survival.
Moreover, green tea EGCG application also enhanced antioxidant activity not only through its antioxidant profiles but also stimulated the production of the body's natural antioxidants in reduced inflammatory response through nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression, observed by Griess reagent and western blotting.
The evidence indicated that green tea EGCG may have a profound effect in reducing serum alpha1-Antitrypsin (AAT) deficiency in initiated the onset of fibromyalgia
The above differentiation were supported by the review of Chronic Inflammatory Diseases and Green Tea Polyphenol, by Dr. Helieh S. Oz at the University of Kentucky Medical Center.
According to the authors, green tea polyphenols are potent antioxidants with important roles in regulating vital signaling pathways in activated inflammatory responses by attenuating nuclear factor (NF)-kappaB IKK, NF-κB in facilitated innate- and adaptive immune responses, cell death and inflammation and cytokines like TNFα, inflammatory markers and cyclooxygenase-2 in elevated symptoms of inflammation and pain.
Dr. Helieh S. in the summary said, "green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways" and "these comprise transcription nuclear factor-kappa B mediated I kappa B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 (through regulating the cytochrome c release from the mitochondria) and intervention with the surge of inflammatory markers like cytokines and production of cyclooxygenase-2"".
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated serum alpha1-Antitrypsin (AAT) deficiency effect in initiated the onset of fibromyalgia. However, the intake of green tea supplements should be taken with extreme care due to recent medical reports of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia by Blanco LE1, de Serres FJ, Fernańdez-Bustillo E, Kassam DA, Arbesú D, Rodríguez C, Torre JC. (PubMed)
(3) Chronic Inflammatory Diseases and Green Tea Polyphenols by Helieh S. Oz(PubMed Central Canada)
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in the US alone.
Serum of alpha1-Antitrypsin (AAT) impregnated in most parts of the body circulates in our body in high concentrations with function in the inhibition of the enzymes of inflammatory cells.
Alpha1-Antitrypsin (AAT) deficiency is a genetic disorder inherited from the parent characterized by of the inability of the body to produce a protein called alpha-1 anti-trypsin (AAT), leading to inflammation of fatty tissue under the skin (subcutaneous), and at other parts of the body, including the joints, the major cause of fibromyalgia.
Additionally, deficiency of AAT enynes also can cause liver and lung damage, leading to poor function of the organ and increasing the risk of cirrhosis, COPD, liver and lung cancer.
Although the deficiency is presented since birth, most patients with the mutated gene do not experience any symptoms until the age of 50 or 60.
According to the statistic, AAT deficiency is one of the most common inherited disorders among Caucasians compared to other race groups.
Approximately over 1% of patients diagnosed with chronic obstructive pulmonary disease (COPD) processes the alpha1-antitrypsin deficiency gene
In the study of the effect of serum of alpha1-Antitrypsin (AAT) and risk of fibromyalgia (FM), researchers at the Hospital Valle del Nalón found that deficiency of AAT has been found in numbers of patients with fibromyalgia (FM) with severe hereditary.
Functional magnetic resonance imaging of these patients revealed significantly greater activity in pain-sensitive areas of the brain in response to cutaneous stimuli, which may be another evidence for a physiological explanation for FM pain.
Furthermore, patients with FM also were found to consist of abnormal profiles of inflammation markers in biopsies analysis.
The results suggested that these patients may have an imbalance level of pro-inflammatory and anti-inflammatory substances, in the soft body tissues caused by alpha1-Antitrypsin (AAT) deficiency.
Due to surprising findings, Dr. Blanco LE, the lead author, after taking into account of other confounders, said, "identification of genetic, familial, and environmental risk factors suspected to participate in the FM syndrome development (may be necessary) to determine the gene frequency of AAT deficiency alleles in FM patients".
Green tea, bioactive polyphenols EGCG, according to the Dr Helieh S in animal model induced by alpha1-Antitrypsin (AAT) (α1-antitrypsin) deficiency exerted a significant anti-inflammatory effect in inhibited the PI3K/Akt signalling pathway with function in activated pro-inflammatory factors through the innate immune response involved in pathogen killing, antigen processing and immune cell survival.
Moreover, green tea EGCG application also enhanced antioxidant activity not only through its antioxidant profiles but also stimulated the production of the body's natural antioxidants in reduced inflammatory response through nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression, observed by Griess reagent and western blotting.
The evidence indicated that green tea EGCG may have a profound effect in reducing serum alpha1-Antitrypsin (AAT) deficiency in initiated the onset of fibromyalgia
The above differentiation were supported by the review of Chronic Inflammatory Diseases and Green Tea Polyphenol, by Dr. Helieh S. Oz at the University of Kentucky Medical Center.
According to the authors, green tea polyphenols are potent antioxidants with important roles in regulating vital signaling pathways in activated inflammatory responses by attenuating nuclear factor (NF)-kappaB IKK, NF-κB in facilitated innate- and adaptive immune responses, cell death and inflammation and cytokines like TNFα, inflammatory markers and cyclooxygenase-2 in elevated symptoms of inflammation and pain.
Dr. Helieh S. in the summary said, "green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways" and "these comprise transcription nuclear factor-kappa B mediated I kappa B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 (through regulating the cytochrome c release from the mitochondria) and intervention with the surge of inflammatory markers like cytokines and production of cyclooxygenase-2"".
Taken together, green tea and its bioactive polyphenols may be considered as a functional food in ameliorated serum alpha1-Antitrypsin (AAT) deficiency effect in initiated the onset of fibromyalgia. However, the intake of green tea supplements should be taken with extreme care due to recent medical reports of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia by Blanco LE1, de Serres FJ, Fernańdez-Bustillo E, Kassam DA, Arbesú D, Rodríguez C, Torre JC. (PubMed)
(3) Chronic Inflammatory Diseases and Green Tea Polyphenols by Helieh S. Oz(PubMed Central Canada)
Broccoli Sprout Inhibits Parameters Associated with Sickle Cell Anemia
Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.
Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout your body.
A long-term deficiency of folate and vitamin B-12 plays a critical role in the production of healthy red blood cells associated with the increased risk of Amenia.
Also, people with the mutated gene inherited from the parent are at substantial risk of the disease. The Duliajan College study suggested that certain genes have been found to induce anemia.
Sickle cell anemia (SCD), a genetic preposition form of anemia is a condition associated with not enough healthy red blood cells to carry adequate oxygen throughout your body.
The red blood cells in sickle cell anemia patines are rigid and sticky with the shapes of sickles or crescent moons.
The normal red blood cells live for about 120 days comapred to the sickle cells that die in 10 to 20 days. In other words, the inability of the body to replace the cell that dies rapidly with new blood cells is a cause of sickle cell anemia.
According to the statistics, provided by the CDC, approximately 100,000 Americans are living with SCD. Ethnically, 1 out of every 365 Black or African-American births, 1 out of every 16,300 Hispanic-American births and 1 in 13 Black or African-American birth are sickle cell trait (SCT) carriers.
Conventionally, except for bone marrow transplant, treatments of sickle cell anemia are to improve quality of life, by relieving symptoms and preventing complications.
Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
With an aim to find a potential ingredient for the treatment of inherited blood disorder, researchers examined the effects of broccoli sprout homogenate (BSH) containing sulforaphane and sulforaphane in the activation of NRF2 on sickle cell disease (SCD).
Nrf2 is a protein that processes the function in the regulation of the expression of antioxidant enzymes against oxidative damage triggered by injury and inflammation.
According to the tested analysis, sulforaphane (SFN) significantly increased the expression of NRF2 associated with the increase of antioxidant enzymes that inhibits oxidative stress such as HMOX1, NQO1, and HBG1 in a dose-dependent manner.
In adults with SCD,
* BSH consumption showed no adverse effects.
* BSH consumption increase the mean relative whole blood mRNA levels NRF2 target HMOX1
* Furthermore, BSH injection increased mean relative mRNA levels of the NRF2 target HBG1, compared to the baseline at end of treatment, without affecting the levels of HbF protein.
In other words, BSH displays a similar effect compared to that of sulforaphane in the promotion of the production of antioxidant enzymes against sickle cell disease (SCD).
Based on the findings, researchers said, "BSH, in the provided doses, is safe in stable SCD patients and may induce changes in gene expression levels".
Taken altogether, broccoli sprout processed abundantly SFN may be considered a functional food for the treatment of SCD, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease by Doss JF1,2, Jonassaint JC3, Garrett ME4, Ashley-Koch AE4, Telen MJ3, Chi JT. (PubMed)
Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout your body.
A long-term deficiency of folate and vitamin B-12 plays a critical role in the production of healthy red blood cells associated with the increased risk of Amenia.
Also, people with the mutated gene inherited from the parent are at substantial risk of the disease. The Duliajan College study suggested that certain genes have been found to induce anemia.
Sickle cell anemia (SCD), a genetic preposition form of anemia is a condition associated with not enough healthy red blood cells to carry adequate oxygen throughout your body.
The red blood cells in sickle cell anemia patines are rigid and sticky with the shapes of sickles or crescent moons.
The normal red blood cells live for about 120 days comapred to the sickle cells that die in 10 to 20 days. In other words, the inability of the body to replace the cell that dies rapidly with new blood cells is a cause of sickle cell anemia.
According to the statistics, provided by the CDC, approximately 100,000 Americans are living with SCD. Ethnically, 1 out of every 365 Black or African-American births, 1 out of every 16,300 Hispanic-American births and 1 in 13 Black or African-American birth are sickle cell trait (SCT) carriers.
Conventionally, except for bone marrow transplant, treatments of sickle cell anemia are to improve quality of life, by relieving symptoms and preventing complications.
Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
With an aim to find a potential ingredient for the treatment of inherited blood disorder, researchers examined the effects of broccoli sprout homogenate (BSH) containing sulforaphane and sulforaphane in the activation of NRF2 on sickle cell disease (SCD).
Nrf2 is a protein that processes the function in the regulation of the expression of antioxidant enzymes against oxidative damage triggered by injury and inflammation.
According to the tested analysis, sulforaphane (SFN) significantly increased the expression of NRF2 associated with the increase of antioxidant enzymes that inhibits oxidative stress such as HMOX1, NQO1, and HBG1 in a dose-dependent manner.
In adults with SCD,
* BSH consumption showed no adverse effects.
* BSH consumption increase the mean relative whole blood mRNA levels NRF2 target HMOX1
* Furthermore, BSH injection increased mean relative mRNA levels of the NRF2 target HBG1, compared to the baseline at end of treatment, without affecting the levels of HbF protein.
In other words, BSH displays a similar effect compared to that of sulforaphane in the promotion of the production of antioxidant enzymes against sickle cell disease (SCD).
Based on the findings, researchers said, "BSH, in the provided doses, is safe in stable SCD patients and may induce changes in gene expression levels".
Taken altogether, broccoli sprout processed abundantly SFN may be considered a functional food for the treatment of SCD, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease by Doss JF1,2, Jonassaint JC3, Garrett ME4, Ashley-Koch AE4, Telen MJ3, Chi JT. (PubMed)
Tuesday, October 22, 2019
Green tea, The Beverage Which Ameliorates Symptoms and Treats Depression and Anxiety Disorders
Green tea may have a potential and positive effect in reducing symptoms of depression and anxiety stress, some scientists suggested.
Depression and anxiety disorders are psychological illnesses. Depression disorder is not the same as anxiety disorder however they often share symptoms similar to those of anxiety.
The causes of depression may be attributed to a number of factors such as genetics, changes in hormone levels, certain medical conditions, stress, grief or difficult life circumstances.
In anxiety, risk factors that associated with the early onset of the disease are family history, long-term under stressful situations and excessive alcohol drinking and use of tobacco, particularly in people who had a childhood history of being abused.
The Mayo Clinic in the classification of anxiety suggested that women are twice as likely as men to experience a generalized anxiety disorder (GAD).
In the comparison of the symptoms of depression and anxiety, one may find several overlaps, including symptoms of sleep problems, trouble concentrating, and fatigue.
Dr. Kathleen Smith, Ph.D. in the classification of the different depression and anxiety wrote, "There are, however, some distinguishing features. People with depression move slowly, and their reactions can seem flattened or dulled. People with anxiety tend to be more keyed up, as they struggle to manage their racing thoughts. Another distinguishing feature is the presence of fear about the future in people with anxiety. Depressed people who do not have anxiety are less likely to be fraught with worry about future events, as they are often resigned to believing that things will continue to be bad. In other words, they may predict the future based on how they feel in the moment".
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world.
The National University Health System, Singapore which launched the study to examine the association between long-term tea consumption and depressive and anxiety symptoms in community-living elderly including 614 elderly aged 60 years and above, who were free of dementia and cognitive impairment suggested base on the Information on tea consumption,
* 59% of the subjects who participated in the study had consumed tea for over 15 years.
* Long-term tea consumption was significantly associated with a reduced odds of having depressive and anxiety symptoms, after adjusting for demographics (i.e., age, gender, education, and ethnicity), comorbid conditions (i.e., heart disease, diabetes, stroke, hypertension, and hyperlipidemia) and long-term coffee consumption.
The findings suggested that long-term tea consumption was associated with reduced depressive and anxiety symptoms among community-living elderly. and that may be the reason that tea's bioactive compounds are used in promoting mental health in aging.
Furthermore, in the evaluate the anti-stress effect of green tea with lowered caffeine, low-caffeine green tea, on humans in a single-blind group comparison and participants (n=20) randomly assigned to low-caffeine or placebo tea groups, researchers showed that according to the state-trait anxiety inventory test.
* The subjective stress in participants was significantly lower in the low-caffeine-group than in the placebo-group during pharmacy practice.
* The level of salivary α-amylase activity, a stress marker, increased significantly after daily pharmacy practice in the placebo group but not in the low-caffeine-group.
These results suggested that the ingestion of low-caffeine green tea suppressed the excessive stress response of students.
Moreover, in the review of a systematically searched on PubMed database and selected studies by predefined eligibility criteria, researcher indicated that in out of 21 studies selected, 4 of which were randomized controlled trials, 12 cross-over studies (both assessed with an adapted version of the DELPHI-list), 4 were cross-sectional studies and one was a cohort study
* Green tea intake exerts a significant influence on the psychopathological symptoms (e.g. reduction of anxiety), cognition (e.g. benefits in memory and attention) and brain function (e.g. activation of working memory seen in functional MRI).
* The effects of green tea are not attributed to a single constituent of the beverage, but the combined influence of both caffeine and l-theanine, whereas separate administration of either substance was found to have a lesser impact.
Taken all together, there is no doubt, standard green tea may be considered a functional food in ameliorating the symptoms of depression and anxiety disorders.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Associations of Long-Term Tea Consumption with Depressive and Anxiety Symptoms in Community-Living Elderly: Findings from the Diet and Healthy Aging Study by Chan SP1, Yong PZ, Sun Y, Mahendran R, Wong JCM, Qiu C, Ng TP, Kua EH, Feng L.(PubMed)
(2) Green tea effects on cognition, mood and human brain function: A systematic review by Mancini E1, Beglinger C2, Drewe J2, Zanchi D1, Lang UE1, Borgwardt S3(PubMed)
(3) Anti-stress Effect of Green Tea with Lowered Caffeine on Humans: A Pilot Study by Unno K1,2, Yamada H3, Iguchi K1, Ishida H4, Iwao Y5, Morita A6, Nakamura Y2.(PubMed)
Depression and anxiety disorders are psychological illnesses. Depression disorder is not the same as anxiety disorder however they often share symptoms similar to those of anxiety.
The causes of depression may be attributed to a number of factors such as genetics, changes in hormone levels, certain medical conditions, stress, grief or difficult life circumstances.
In anxiety, risk factors that associated with the early onset of the disease are family history, long-term under stressful situations and excessive alcohol drinking and use of tobacco, particularly in people who had a childhood history of being abused.
The Mayo Clinic in the classification of anxiety suggested that women are twice as likely as men to experience a generalized anxiety disorder (GAD).
In the comparison of the symptoms of depression and anxiety, one may find several overlaps, including symptoms of sleep problems, trouble concentrating, and fatigue.
Dr. Kathleen Smith, Ph.D. in the classification of the different depression and anxiety wrote, "There are, however, some distinguishing features. People with depression move slowly, and their reactions can seem flattened or dulled. People with anxiety tend to be more keyed up, as they struggle to manage their racing thoughts. Another distinguishing feature is the presence of fear about the future in people with anxiety. Depressed people who do not have anxiety are less likely to be fraught with worry about future events, as they are often resigned to believing that things will continue to be bad. In other words, they may predict the future based on how they feel in the moment".
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world.
The National University Health System, Singapore which launched the study to examine the association between long-term tea consumption and depressive and anxiety symptoms in community-living elderly including 614 elderly aged 60 years and above, who were free of dementia and cognitive impairment suggested base on the Information on tea consumption,
* 59% of the subjects who participated in the study had consumed tea for over 15 years.
* Long-term tea consumption was significantly associated with a reduced odds of having depressive and anxiety symptoms, after adjusting for demographics (i.e., age, gender, education, and ethnicity), comorbid conditions (i.e., heart disease, diabetes, stroke, hypertension, and hyperlipidemia) and long-term coffee consumption.
The findings suggested that long-term tea consumption was associated with reduced depressive and anxiety symptoms among community-living elderly. and that may be the reason that tea's bioactive compounds are used in promoting mental health in aging.
Furthermore, in the evaluate the anti-stress effect of green tea with lowered caffeine, low-caffeine green tea, on humans in a single-blind group comparison and participants (n=20) randomly assigned to low-caffeine or placebo tea groups, researchers showed that according to the state-trait anxiety inventory test.
* The subjective stress in participants was significantly lower in the low-caffeine-group than in the placebo-group during pharmacy practice.
* The level of salivary α-amylase activity, a stress marker, increased significantly after daily pharmacy practice in the placebo group but not in the low-caffeine-group.
These results suggested that the ingestion of low-caffeine green tea suppressed the excessive stress response of students.
Moreover, in the review of a systematically searched on PubMed database and selected studies by predefined eligibility criteria, researcher indicated that in out of 21 studies selected, 4 of which were randomized controlled trials, 12 cross-over studies (both assessed with an adapted version of the DELPHI-list), 4 were cross-sectional studies and one was a cohort study
* Green tea intake exerts a significant influence on the psychopathological symptoms (e.g. reduction of anxiety), cognition (e.g. benefits in memory and attention) and brain function (e.g. activation of working memory seen in functional MRI).
* The effects of green tea are not attributed to a single constituent of the beverage, but the combined influence of both caffeine and l-theanine, whereas separate administration of either substance was found to have a lesser impact.
Taken all together, there is no doubt, standard green tea may be considered a functional food in ameliorating the symptoms of depression and anxiety disorders.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Associations of Long-Term Tea Consumption with Depressive and Anxiety Symptoms in Community-Living Elderly: Findings from the Diet and Healthy Aging Study by Chan SP1, Yong PZ, Sun Y, Mahendran R, Wong JCM, Qiu C, Ng TP, Kua EH, Feng L.(PubMed)
(2) Green tea effects on cognition, mood and human brain function: A systematic review by Mancini E1, Beglinger C2, Drewe J2, Zanchi D1, Lang UE1, Borgwardt S3(PubMed)
(3) Anti-stress Effect of Green Tea with Lowered Caffeine on Humans: A Pilot Study by Unno K1,2, Yamada H3, Iguchi K1, Ishida H4, Iwao Y5, Morita A6, Nakamura Y2.(PubMed)
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