Scientists may have found a herbal plant for the prevention and treatment of hepatitis infection with no side effects, according to studies.
Hepatitis is a condition characterized by the destruction of a number of liver cells and the presence of inflammatory cells in the liver tissue.
Mose cases of hepatitis are caused by infection of the hepatitis viruses. However, excessive alcohol drinking, disorders of the gallbladder or pancreas, and long-term use of certain medication are also associated with the onset of the disease.
The term is unfortunately commonly used to refer to a particular group of viruses such as Hepatitis A, B, and C.
If you are experiencing persistent symptoms of fatigue, flu-like symptoms, dark urine, pale stool abdominal pain, and jaundice. please check with your doctor to rule out the possibility of hepatitis.
In some cases, hepatitis can also be caused by to immune disease in which the immune system mistakenly attacks the liver, leading to mild to severe chronic inflammation that hinders the liver function.
Dr. Yoshio Aizawa, the lead author in the liver diseases research team at the Jikei University Katsushika Medical Center in the examination of the complication of autoimmune hepatitis, wrote, "Autoimmune hepatitis (AIH) is a chronic progressive liver disease characterized by high levels of aminotransferases and autoantibodies, hypergammaglobulinemia, and interface hepatitis"
"There is confusion as to the definition of the disease entity and its boundaries in the diagnosis of overlap syndrome, drug-induced autoimmune hepatitis, and AIH with concomitant nonalcoholic fatty liver disease (NAFLD) or chronic hepatitis C" and "Immunologically, disruption of the immune tolerance to autologous liver antigens may be a trigger of AIH".
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The herbal plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, such as neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
With an aim to find a natural compound or remedy for the treatment of hepatitis with no side effects, researchers evaluated the anti-hepatitis C virus (HCV) activity of andrographolide, a diterpenoid lactone extracted from Andrographis paniculata.
In HCV replicon and HCVcc infectious systems, andrographolide time- and dose-dependently suppressed HCV replication.
Combined with anti-hepatitis medicines, such as IFN-α, an inhibitor targeting HCV NS3/4A protease (telaprevir), or NS5B polymerase (PSI-7977), andrographolide exhibited a significant synergistic effect.
The anti antiviral effects of the diterpenoid lactone extracted from Andrographis paniculata.were attenuated by an HO-1-specific inhibitor or the inhibition of HO-1 gene involved the production of oxidative in contributing the anti-HCV activity.
Furthermore, Andrographolide also activated the alternation of the protein (p38 MAPK) associated with the response to stress stimuli.
Additionally, the Banaras Hindu University, study in the evaluation of the anti-hepatitis effects of Kalmegh(Andrographis paniculata Nees) in the decoction form in patients of infective hepatitis.
Injection of the decoction showed a marked symptomatic improvement in the majority of the cases.
The decoction also showed a statistically highly significant decrease in various liver function.
Moreover, the application also increased significantly total serum globulin fraction protein which plays a critical role in liver functioning.
At the final day of the experiment, researchers said, "total assessment 80% cases of this series were cured and 20% of patients were relieved".
Taken altogether, herbal Andrographis may be considered a functional remedy for the prevention of liver infection and combined with primary medicine for the treatment of liver diseases, pending to the confirmation of large sample size and multicenter human study.
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells by Lee JC, Tseng CK, Young KC, Sun HY, Wang SW, Chen WC, Lin CK, Wu YH.(PubMed)
(2) Clinical studies on kalmegh (andrographis paniculata nees) in infective hepatitis by Chturvedi GN, Tomar GS, Tiwari SK, Singh KP.(PubMed)
(3) Autoimmune hepatitis: current challenges and future prospects by Yoshio Aizawa and Atsushi Hokari. (PMC)
Sunday, November 24, 2019
Herbal Ashwagandha Gobbles Up Lung Cancer Cells in Vitro
Cancer is a class of diseases caused by cell growth and multiplication disorderly and uncontrollably due to the alternation of the DNA.
After colonizing the entire tissues of the specific organ, the oversize tumor cell can travel a distance away from the originated site to invade other healthy tissues, via lymph or blood.
The most advanced stage of cancer may result in the death of the patients.
The lung is a vital organ located near the backbone on either side of the heart with major functions to inhale oxygen from the air to the bloodstream that nourishes the body cells and exhale carbon dioxide from the bloodstream.
Other functions of the lung are to maintain the right levels of pH, filter out blood clots, protect the heart against shock, infection, and speech.
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers is derived from epithelial cells.
According to the statistics provided by the American Lung Cancer Association, lung cancer is the leading cancer killer in both men and women in the U.S. in 2018, 154,050 Americans died from lung cancer in 2018, accounting for approximately 25 percent of all cancer deaths.
The exact causes of lung cancer are unknown. However, passive smoking, tobacco smoking are 2 of the most common risk factors were found in patients with the disease.
Other risk factors are
* Exposure to certain chemicals
The risk of lung cancer for people who inhale or exposing certain industrial chemicals such as radon gas, arsenic, chromium, nickel,..in the workplace is substantially higher compared to non-exposures.
* Family history
The risk of lung cancer increased if one of the members of the direct family has lung cancer.
* Lung disease
Risk of lung cancer increases if you have or previously had certain types of lung disease
* Excessive drinking
According to the study by Freudenheim et al., R. Curtis Ellison MD suggested that alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent ingredient for the treatment of lung cancer, researchers examined the effects of Withaferin A (WA) a bioactive lactone, isolated from Withania somnifera on lung tumor cells both in vitro and in vivo.
According to the tested differentiation, WA entered a significant anti lung cancer cell activity by -mediating cytotoxicity involved in reactive oxygen species (ROS) expression.
On NSCLC cell line A549 compared to non-carcinoma WI-38 and PBMC cell lines as controls, WA induced oxidative damage to NSCLC cells without affecting much of normal cells in a dose-dependent manner.
In a comparison of the anti lung cancer effect among a chlorinated steroidal lactone (27-acetoxy-4β,6α-dihydroxy-5β-chloro-1-oxowitha-2,24-dienolide), a diepoxy withanolide (5β,6β,14α,15α-diepoxy-4β,27-dihydroxy-1-oxowitha-2,24-dienolide), and withaferin A, researchers found that all 3 compounds exhibited growth inhibition and cytotoxic activity against human lung cancer cell line (NCI-H460).
Withaferin A was found to have a most effective activity at GI(50)=0.18 μg/mL and LC(50)=0.45 μg/mL) compared to the other 2 chemical constituents.
Taken altogether, Ashwagandha processed abundantly bioactive compounds that may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of lung cancer, pending to the results of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withaferin A induces mitochondrial-dependent apoptosis in non-small cell lung cancer cells via generation of reactive oxygen species by Liu X1, Chen L, Liang T, Tian XD, Liu Y, Zhang T. (PubMed)
(2) Chlorinated and diepoxy withanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line by Choudhary MI1, Hussain S, Yousuf S, Dar A, Mudassar, Atta-ur-Rahman. (PubMed)
After colonizing the entire tissues of the specific organ, the oversize tumor cell can travel a distance away from the originated site to invade other healthy tissues, via lymph or blood.
The most advanced stage of cancer may result in the death of the patients.
The lung is a vital organ located near the backbone on either side of the heart with major functions to inhale oxygen from the air to the bloodstream that nourishes the body cells and exhale carbon dioxide from the bloodstream.
Other functions of the lung are to maintain the right levels of pH, filter out blood clots, protect the heart against shock, infection, and speech.
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers is derived from epithelial cells.
According to the statistics provided by the American Lung Cancer Association, lung cancer is the leading cancer killer in both men and women in the U.S. in 2018, 154,050 Americans died from lung cancer in 2018, accounting for approximately 25 percent of all cancer deaths.
The exact causes of lung cancer are unknown. However, passive smoking, tobacco smoking are 2 of the most common risk factors were found in patients with the disease.
Other risk factors are
* Exposure to certain chemicals
The risk of lung cancer for people who inhale or exposing certain industrial chemicals such as radon gas, arsenic, chromium, nickel,..in the workplace is substantially higher compared to non-exposures.
* Family history
The risk of lung cancer increased if one of the members of the direct family has lung cancer.
* Lung disease
Risk of lung cancer increases if you have or previously had certain types of lung disease
* Excessive drinking
According to the study by Freudenheim et al., R. Curtis Ellison MD suggested that alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent ingredient for the treatment of lung cancer, researchers examined the effects of Withaferin A (WA) a bioactive lactone, isolated from Withania somnifera on lung tumor cells both in vitro and in vivo.
According to the tested differentiation, WA entered a significant anti lung cancer cell activity by -mediating cytotoxicity involved in reactive oxygen species (ROS) expression.
On NSCLC cell line A549 compared to non-carcinoma WI-38 and PBMC cell lines as controls, WA induced oxidative damage to NSCLC cells without affecting much of normal cells in a dose-dependent manner.
In a comparison of the anti lung cancer effect among a chlorinated steroidal lactone (27-acetoxy-4β,6α-dihydroxy-5β-chloro-1-oxowitha-2,24-dienolide), a diepoxy withanolide (5β,6β,14α,15α-diepoxy-4β,27-dihydroxy-1-oxowitha-2,24-dienolide), and withaferin A, researchers found that all 3 compounds exhibited growth inhibition and cytotoxic activity against human lung cancer cell line (NCI-H460).
Withaferin A was found to have a most effective activity at GI(50)=0.18 μg/mL and LC(50)=0.45 μg/mL) compared to the other 2 chemical constituents.
Taken altogether, Ashwagandha processed abundantly bioactive compounds that may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of lung cancer, pending to the results of large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withaferin A induces mitochondrial-dependent apoptosis in non-small cell lung cancer cells via generation of reactive oxygen species by Liu X1, Chen L, Liang T, Tian XD, Liu Y, Zhang T. (PubMed)
(2) Chlorinated and diepoxy withanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line by Choudhary MI1, Hussain S, Yousuf S, Dar A, Mudassar, Atta-ur-Rahman. (PubMed)
Emodin, the Bioactive Ingredient of Herbal Cascara Sagrada (Rhamnus purshiana) which Protects Our Body Against the Onset of Metabolic Syndrome
Emodin, a major bioactive compound found in herbal Cascara Sagrada may be considered an adjunct therapy in the prevention and treatment of metabolic syndrome, some scientists suggested.
Metabolic syndrome is a cluster of conditions associated with the increased risk of diabetes, heart disease and stroke, including high blood pressure and sugar, excess body weight and obesity, abnormally high levels of blood cholesterol or triglyceride levels.
Researchers do not know the exact causes of metabolic syndrome. However, they do know that ethnicity and family history and mutation of genes which causes insulin resistance inherited from the parents are the numbers of risk factors associated with the early onset of the condition.
Certain medical conditions such as polycystic ovarian syndrome and gallstone disease, nonalcoholic fatty livers are also the prevalent risk factors for the development of the metabolic syndrome.
It is misleading that metabolic syndrome can only cause heart disease, diabetes, and stroke. According to the National Heart, Lung and Blood Institute, people with metabolic syndrome are also associated with an increased risk of excessive blood clotting and persistent low-grade inflammation throughout the body.
Treatment of metabolic syndrome should be followed closely to the underlining risk factors of abdominal obesity, physical inactivity, and atherogenic/diabetogenic diet and drug therapy for specific metabolic risk factors should be considered for those at high or moderately high 10-year absolute risk of atherosclerotic cardiovascular disease, according to the American Heart Association and the National Heart, Lung, and Blood Institute slightly modifies and clarifies the diagnostic criteria for the metabolic syndrome.
Medication used to reduce the level of progression of metabolic syndrome-related disorders including thiazolidinediones, GLP-1 agonists, and DPP-4 inhibitors may be effective, however, they can induce serious side effects such as edema, weight gain, macular edema, and heart failure.
Some patients who take the medicine may also experience side effects of hypoglycemia, decrease hematocrit and hemoglobin levels and increased bone fracture risk.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
Cascara sagrada bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
The chemical ingredients
Besides the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, hydroxy anthracene derivatives (HAD).
In the concerns of the side effects of conventional medicine used for the treatment of metabolic syndrome, researchers at the Shanghai Institute of Materia Medica launched an investigation of the effect of emodin, a natural product and active ingredient of various Chinese herbs including Cascara Sagrada in metabolic disorders in diet-induced obese (DIO) mice.
Emodin exerted a significant effect as a potent and selective 11beta-HSD1 inhibitor against insulin resistance and with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively
11β-HSD1, a family of enzymes which have been found to associate with the risk of insulin resistance.
Furthermore, single oral administration of emodin inhibited 11beta-HSD1 activity of liver and fat significantly in mice without reversing the prednisone and dexamethasone-induced insulin resistance.
In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism and lowered blood glucose and hepatic phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase mRNA.
Phosphoenolpyruvate carboxykinase (PEPCK) is associated with the control of hepatic glucose output.
Glucose-6-phosphatase mRNA is increased to some extents in the kidney and liver of diabetic rats.
The findings suggested the potential value of analogs of emodin for the treatment of metabolic syndrome or type 2 diabetes.
Moreover, researchers at the extended study of the effect emodin in metabolic syndrome mice associated with 11beta-HSD1 activity also discovered that emodin inhibited the 11β-HSD1 activity in 3T3-L1 adipocytes in concentration- and time-dependent manners (the IC₅₀ values of 7.237 and 4.204 μmol/L, respectively, after 1 and 24 h treatment, through suppressing the 11-dehydrocorticosterone-in the generation of corticosterone without affecting corticosterone-induced adipogenesis in normal tissues..
3T3-L1 adipocytes are used as a cell culture model of insulin resistance
-
Adipogenesis is the process of cell differentiation from pre-adipocytes to adipocytes.
Moreover, emodin (3 μmol/L) partly reversed the impaired insulin-stimulated glucose uptake and adiponectin secretion induced by 11-dehydrocorticosterone but not those induced by corticosterone.
In ob/ob mice, long-term emodin administration decreased 11β-HSD1 activity in mesenteric adipose tissues, lowered non-fasting and fasting blood glucose levels, and improved glucose tolerance.
Dr. Wang YJ, the lead scientist, after taking into account co and confounders, wrote, "Emodin improves the inactive glucocorticoid-induced adipose tissue dysfunction by selective inhibition on 11β-HSD1 in adipocyte in vitro and improves glycemic control in ob/ob mice".
Taken altogether, Cascara Sagrada bioactive compound emodin may be considered an adjunct supplement used alone for the prevention or combined with other conventional medicine for the treatment of metabolic syndrome without inducing adverse effects.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compound emodin during the course of the disease will be necessary to complete the picture of Cascara sagrada anti-metabolic syndrome possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1). "Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice" by Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y. (PubMed)
(2). Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts the anti-diabetic effect in ob/ob mice. by Wang YJ, Huang SL, Feng Y, Ning MM, Leng Y. (PubMed)
Metabolic syndrome is a cluster of conditions associated with the increased risk of diabetes, heart disease and stroke, including high blood pressure and sugar, excess body weight and obesity, abnormally high levels of blood cholesterol or triglyceride levels.
Researchers do not know the exact causes of metabolic syndrome. However, they do know that ethnicity and family history and mutation of genes which causes insulin resistance inherited from the parents are the numbers of risk factors associated with the early onset of the condition.
Certain medical conditions such as polycystic ovarian syndrome and gallstone disease, nonalcoholic fatty livers are also the prevalent risk factors for the development of the metabolic syndrome.
It is misleading that metabolic syndrome can only cause heart disease, diabetes, and stroke. According to the National Heart, Lung and Blood Institute, people with metabolic syndrome are also associated with an increased risk of excessive blood clotting and persistent low-grade inflammation throughout the body.
Treatment of metabolic syndrome should be followed closely to the underlining risk factors of abdominal obesity, physical inactivity, and atherogenic/diabetogenic diet and drug therapy for specific metabolic risk factors should be considered for those at high or moderately high 10-year absolute risk of atherosclerotic cardiovascular disease, according to the American Heart Association and the National Heart, Lung, and Blood Institute slightly modifies and clarifies the diagnostic criteria for the metabolic syndrome.
Medication used to reduce the level of progression of metabolic syndrome-related disorders including thiazolidinediones, GLP-1 agonists, and DPP-4 inhibitors may be effective, however, they can induce serious side effects such as edema, weight gain, macular edema, and heart failure.
Some patients who take the medicine may also experience side effects of hypoglycemia, decrease hematocrit and hemoglobin levels and increased bone fracture risk.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
Cascara sagrada bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
The chemical ingredients
Besides the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, hydroxy anthracene derivatives (HAD).
In the concerns of the side effects of conventional medicine used for the treatment of metabolic syndrome, researchers at the Shanghai Institute of Materia Medica launched an investigation of the effect of emodin, a natural product and active ingredient of various Chinese herbs including Cascara Sagrada in metabolic disorders in diet-induced obese (DIO) mice.
Emodin exerted a significant effect as a potent and selective 11beta-HSD1 inhibitor against insulin resistance and with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively
11β-HSD1, a family of enzymes which have been found to associate with the risk of insulin resistance.
Furthermore, single oral administration of emodin inhibited 11beta-HSD1 activity of liver and fat significantly in mice without reversing the prednisone and dexamethasone-induced insulin resistance.
In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism and lowered blood glucose and hepatic phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase mRNA.
Phosphoenolpyruvate carboxykinase (PEPCK) is associated with the control of hepatic glucose output.
Glucose-6-phosphatase mRNA is increased to some extents in the kidney and liver of diabetic rats.
The findings suggested the potential value of analogs of emodin for the treatment of metabolic syndrome or type 2 diabetes.
Moreover, researchers at the extended study of the effect emodin in metabolic syndrome mice associated with 11beta-HSD1 activity also discovered that emodin inhibited the 11β-HSD1 activity in 3T3-L1 adipocytes in concentration- and time-dependent manners (the IC₅₀ values of 7.237 and 4.204 μmol/L, respectively, after 1 and 24 h treatment, through suppressing the 11-dehydrocorticosterone-in the generation of corticosterone without affecting corticosterone-induced adipogenesis in normal tissues..
3T3-L1 adipocytes are used as a cell culture model of insulin resistance
-
Adipogenesis is the process of cell differentiation from pre-adipocytes to adipocytes.
Moreover, emodin (3 μmol/L) partly reversed the impaired insulin-stimulated glucose uptake and adiponectin secretion induced by 11-dehydrocorticosterone but not those induced by corticosterone.
In ob/ob mice, long-term emodin administration decreased 11β-HSD1 activity in mesenteric adipose tissues, lowered non-fasting and fasting blood glucose levels, and improved glucose tolerance.
Dr. Wang YJ, the lead scientist, after taking into account co and confounders, wrote, "Emodin improves the inactive glucocorticoid-induced adipose tissue dysfunction by selective inhibition on 11β-HSD1 in adipocyte in vitro and improves glycemic control in ob/ob mice".
Taken altogether, Cascara Sagrada bioactive compound emodin may be considered an adjunct supplement used alone for the prevention or combined with other conventional medicine for the treatment of metabolic syndrome without inducing adverse effects.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compound emodin during the course of the disease will be necessary to complete the picture of Cascara sagrada anti-metabolic syndrome possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1). "Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice" by Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y. (PubMed)
(2). Emodin, an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, regulates adipocyte function in vitro and exerts the anti-diabetic effect in ob/ob mice. by Wang YJ, Huang SL, Feng Y, Ning MM, Leng Y. (PubMed)
Herbal Chamomile on Dermatitis
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Dermatitis or eczema is defined as a condition of inflammation of skin including itchy, erythematous, vesicular, weeping, and crusting patches.
The use of chamomile oil in folk medicine for the treatment of skin disorder may have found to be effective in modern medicine, according to Howon University, application of German chamomile oil to alleviating atopic dermatitis, such as reduced serum IgG1 level and significantly lower serum histamine level through influencing of Th2 cell activation(1).
Dr. Dohil MA. in the study of herbal effects on in atopic dermatitis and another inflammatory skin disease indicated that there may be a positive effect of herbal medicine, including chamomile through the present recent multicenter and international clinical studies that support their efficacy and safety profile for a variety of inflammatory skin conditions(2). and herbs containing anti-inflammatory activity such as chamomile may be particularly well suited as alternatives to pharmacologic therapies in chronic conditions for which long-term use is required,(3), Dr. Wu J. said.
Although, German chamomile may be effective for the treatment of skin disorder, it was found to have an allergic effect in some patients, in external use of chamomile tea or the use of chamomile-containing topical herbal remedies, due to its chemical constituent herniarin(4).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.by Lee SH1, Heo Y, Kim YC.(PubMed)
(2) Natural ingredients in atopic dermatitis and other inflammatory skin disease.
Dohil MA.(PubMed)
(3) Anti-inflammatory ingredients by Wu J.(PubMed)
(4) The coumarin herniarin as a sensitizer in German chamomile[Chamomilla recutita (L.) Rauschert, Compositae] by Paulsen E1, Otkjaer A, Andersen KE.(PubMed)
Dermatitis or eczema is defined as a condition of inflammation of skin including itchy, erythematous, vesicular, weeping, and crusting patches.
The use of chamomile oil in folk medicine for the treatment of skin disorder may have found to be effective in modern medicine, according to Howon University, application of German chamomile oil to alleviating atopic dermatitis, such as reduced serum IgG1 level and significantly lower serum histamine level through influencing of Th2 cell activation(1).
Dr. Dohil MA. in the study of herbal effects on in atopic dermatitis and another inflammatory skin disease indicated that there may be a positive effect of herbal medicine, including chamomile through the present recent multicenter and international clinical studies that support their efficacy and safety profile for a variety of inflammatory skin conditions(2). and herbs containing anti-inflammatory activity such as chamomile may be particularly well suited as alternatives to pharmacologic therapies in chronic conditions for which long-term use is required,(3), Dr. Wu J. said.
Although, German chamomile may be effective for the treatment of skin disorder, it was found to have an allergic effect in some patients, in external use of chamomile tea or the use of chamomile-containing topical herbal remedies, due to its chemical constituent herniarin(4).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.by Lee SH1, Heo Y, Kim YC.(PubMed)
(2) Natural ingredients in atopic dermatitis and other inflammatory skin disease.
Dohil MA.(PubMed)
(3) Anti-inflammatory ingredients by Wu J.(PubMed)
(4) The coumarin herniarin as a sensitizer in German chamomile[Chamomilla recutita (L.) Rauschert, Compositae] by Paulsen E1, Otkjaer A, Andersen KE.(PubMed)
Saturday, November 23, 2019
Herbal Cascara sagrada Kills Pancreatic Cancer Cells in Vivo and Vitro
Herbal Cascara sagrada may process a major bioactive compound targeted by the pharmaceutical companies for the development of conventional medicine in the treatment of pancreatic cancer, some scientists suggested.
Primary pancreatic cancer is cancer that originates in the pancreas as the result of the alternation of DNA of the cell.
Most cases of pancreas cancer start in the cell on the surface of the inner lining tissue. However, as the cancer progress, the malignant cells of the pancreas, although unusual may travel a far distance away to infect other healthy tissue and organs.
The pancreas cancer was found to be the site of metastasis from renal cell cancer, lung, colon and breast cancers.
Scientists do not know the exact causes of pancreatic cancers, but they do know several risk factors that can make a person more likely to get the disease, including the genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4).
Other prevalent risk factors, including long-term use of tobacco, exposure to certain chemicals, overweight, and obesity, and unpreventable risk factors of family history, gender, the increase of age and ethnicity are associated with the early onset of pancreatic cancer.
However, most people with some of the above risk factors do not get the disease.
Researchers at the John Hoskins medical center suggested an unhealthy diet high in meats, cholesterol, fried foods, and nitrosamines may increase risk, while diets high in fruits and vegetables reduce the risk of pancreatic cancer.
In the change of lifestyle in the reduced risk of pancreatic cancer, the research team in the cancer program at the Ústav preventivního lékařství, after analyzing the total of 529 subjects, including 309 cases and 220 control subjects newly diagnosed patients with pancreatic cancer who lived in the region selected in hospitals in three centers (University Hospital Olomouc, University Hospital Ostrava, Hospital Ceske Budejovice) said, "Physical activity, dietary measures that will lead to weight loss and education to non-smoking can have a significant impact on the primary prevention of cancer."
These results suggested that if you follow a healthy diet and lifestyle with moderate exercise, your risk of pancreatic cancer is substantially lower compared to others.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America,
The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, other compounds of Cascara sagrada include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the reassessment of the effects of Emodin in inducing the apoptosis of pancreatic cancer cells and inhibiting the tumor growth, researchers at the Zhejiang University School of Medicine conducted an investigation to examine pathways activated by Emodin during the anti-pancreatic cancer process.
In vivo and vitro, the application of Emodin up-regulated the function of cancers cell death programmer and down-regulated the expression of proteins that are responsible for the production of the new blood vessels to provide energy to the pancreatic cancer tumor.
Emodins also reduced the expression of eNOS phosphorylation in regulating the vascular angiogenesis which was promoted by the tumor observed by both immunohistochemistry and western blot analysis.
However, Emodin had no direct effect on VEGFR expression in vascular angiogenesis, in vivo
These results suggested that Emodin may be a potential anti-tumor effect on pancreatic cancer via apoptosis and suppression of angiogenesis.
Additionally, in the study to explore the role of XIAP and NF-κB in potentiating the antitumor effect of gemcitabine by Emodin in pancreatic cancer, researchers found that
* In Human pancreatic cancer cells SW1990, Emodin or their combination (gemcitabine plus emodin) induces cellular proliferation and apoptosis.
* The combination therapy is more significantly inhibited SW1990 cell growth and induced a higher percentage of apoptosis, compared to those of Emodin treatment.
* Emodin or emodin plus gemcitabine downregulated the expression of XIAP and NF-κB similar to the above study, compared to the control group in vitro
* The combination of emodin and gemcitabine showed the more significant reduction in the T/NT ratio, an indication of the risk of cancer onset, SUV, an indication on the response to cancer treatment and tumor weight compared to monotherapy.
* Emodin enhanced tumor apoptosis induced by gemcitabine in vivo.
These results suggested that Emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo by downregulation of NF-κB expression, thus inhibiting the expression of XIAP.
Where X-linked inhibitor of apoptosis protein (XIAP) plays a key role in the survival and also promotes invasiveness.in cancer cells.
Taken altogether, herbal Cascara sagrada processed high levels of bioactive compound Emodin may be considered a functional herb for the prevention of pancreatic cancer and an adjunct therapy combined with primary medicine for the treatment of pancreatic cancer.
Further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Cascara sagrada anti-pancreatic cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis by Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL. (PubMed)
(2). Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo by Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ.(PubMed)(3). [Pancreatic cancer and lifestyle factors].[Article in Czech] by Azeem K1, Sevčíková J, Tomášková H, Horáková D, Procházka V, Martínek A, Shonová O, Janout V, Kollárová H. (PubMed)
Primary pancreatic cancer is cancer that originates in the pancreas as the result of the alternation of DNA of the cell.
Most cases of pancreas cancer start in the cell on the surface of the inner lining tissue. However, as the cancer progress, the malignant cells of the pancreas, although unusual may travel a far distance away to infect other healthy tissue and organs.
The pancreas cancer was found to be the site of metastasis from renal cell cancer, lung, colon and breast cancers.
Scientists do not know the exact causes of pancreatic cancers, but they do know several risk factors that can make a person more likely to get the disease, including the genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4).
Other prevalent risk factors, including long-term use of tobacco, exposure to certain chemicals, overweight, and obesity, and unpreventable risk factors of family history, gender, the increase of age and ethnicity are associated with the early onset of pancreatic cancer.
However, most people with some of the above risk factors do not get the disease.
Researchers at the John Hoskins medical center suggested an unhealthy diet high in meats, cholesterol, fried foods, and nitrosamines may increase risk, while diets high in fruits and vegetables reduce the risk of pancreatic cancer.
In the change of lifestyle in the reduced risk of pancreatic cancer, the research team in the cancer program at the Ústav preventivního lékařství, after analyzing the total of 529 subjects, including 309 cases and 220 control subjects newly diagnosed patients with pancreatic cancer who lived in the region selected in hospitals in three centers (University Hospital Olomouc, University Hospital Ostrava, Hospital Ceske Budejovice) said, "Physical activity, dietary measures that will lead to weight loss and education to non-smoking can have a significant impact on the primary prevention of cancer."
These results suggested that if you follow a healthy diet and lifestyle with moderate exercise, your risk of pancreatic cancer is substantially lower compared to others.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America,
The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, other compounds of Cascara sagrada include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the reassessment of the effects of Emodin in inducing the apoptosis of pancreatic cancer cells and inhibiting the tumor growth, researchers at the Zhejiang University School of Medicine conducted an investigation to examine pathways activated by Emodin during the anti-pancreatic cancer process.
In vivo and vitro, the application of Emodin up-regulated the function of cancers cell death programmer and down-regulated the expression of proteins that are responsible for the production of the new blood vessels to provide energy to the pancreatic cancer tumor.
Emodins also reduced the expression of eNOS phosphorylation in regulating the vascular angiogenesis which was promoted by the tumor observed by both immunohistochemistry and western blot analysis.
However, Emodin had no direct effect on VEGFR expression in vascular angiogenesis, in vivo
These results suggested that Emodin may be a potential anti-tumor effect on pancreatic cancer via apoptosis and suppression of angiogenesis.
Additionally, in the study to explore the role of XIAP and NF-κB in potentiating the antitumor effect of gemcitabine by Emodin in pancreatic cancer, researchers found that
* In Human pancreatic cancer cells SW1990, Emodin or their combination (gemcitabine plus emodin) induces cellular proliferation and apoptosis.
* The combination therapy is more significantly inhibited SW1990 cell growth and induced a higher percentage of apoptosis, compared to those of Emodin treatment.
* Emodin or emodin plus gemcitabine downregulated the expression of XIAP and NF-κB similar to the above study, compared to the control group in vitro
* The combination of emodin and gemcitabine showed the more significant reduction in the T/NT ratio, an indication of the risk of cancer onset, SUV, an indication on the response to cancer treatment and tumor weight compared to monotherapy.
* Emodin enhanced tumor apoptosis induced by gemcitabine in vivo.
These results suggested that Emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo by downregulation of NF-κB expression, thus inhibiting the expression of XIAP.
Where X-linked inhibitor of apoptosis protein (XIAP) plays a key role in the survival and also promotes invasiveness.in cancer cells.
Taken altogether, herbal Cascara sagrada processed high levels of bioactive compound Emodin may be considered a functional herb for the prevention of pancreatic cancer and an adjunct therapy combined with primary medicine for the treatment of pancreatic cancer.
Further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Cascara sagrada anti-pancreatic cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis by Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL. (PubMed)
(2). Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo by Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ.(PubMed)(3). [Pancreatic cancer and lifestyle factors].[Article in Czech] by Azeem K1, Sevčíková J, Tomášková H, Horáková D, Procházka V, Martínek A, Shonová O, Janout V, Kollárová H. (PubMed)
Herbal Cat's claw, The Anti Cancers Chemotherapeutic Remedy
Cat's claw found in the tropical jungles of South and Central America may have a potential effect in reducing the risk and treatment of the early onset of irregular cell growth, some scientists suggested.
Cancers are a class of chronic diseases associated with cell growth in the tissue and organs. At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.
There are many types of cancer, depending on the location where cancer begins.
As of today, researchers do not know what are the exact cause of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.
Genetic mutation od BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancer and alternation of gene PTEN.that suppress the growth of tumors also increase the risk of cancers.
Dr. N Parsa in the study "Environmental Factors Inducing Human Cancers" wrote, "(Environment toxins cause) genetic mutations that would eventually alter the normal pathway of cellular proliferation and differentiation. Genetic mutations in four groups of genes; (Oncogenes, Tumor suppressor genes, Apoptosis genes, and DNA repair genes) play a vital role in altering the normal cell division" and " Inhibition of carcinogenic exposures wherever possible should be the goal of cancer prevention programs to reduce exposures from all environmental carcinogens".
The statement illustrated that environmentally induced genetic alternation at the cellular levels can initiate the early onset of cancer.
According to the World Cancer Research Fund UK What you eat can have a big impact on your risk of developing cancer. eating too much fat and sugar and less of fruits and vegetables are the most prevalent risk factors of cancers.
Truly, "Cancer is a Preventable Disease that Requires Major Lifestyle Changes", Dr. Preetha Anand, the lead scientist in the medical literature said, "Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle" and "cancer prevention requires smoking cessation, increased ingestion of fruits and vegetables, moderate use of alcohol, caloric restriction, exercise, avoidance of direct exposure to sunlight, minimal meat consumption, use of whole grains, use of vaccinations, and regular check-ups".
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The Chemical Ingredients
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchona, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine.
In the study of anti-cancer effect of the preparation Cat's claw in several cancer cell lines to determine the IC (50) values with different quantitative and qualitative oxindole alkaloid composition: B/W(37) --bark extracted in water at 37 °C, B/W(b)--bark extracted in boiling water, B/50E(37) --bark extracted in 50% ethanol at 37 °C, B/E(b)--bark extracted in boiling 96% ethanol, B/96E(37) --bark extracted in 96% ethanol at 37 °C and B/SRT--bark extracted in water and dichloromethane researchers found that
* A high correlation between the total oxindole alkaloid content (from 0.43% to 50.40% d.m.) and the antiproliferative activity of the preparations (IC(50) from >1000 μg/ml to 23.57 μg/ml).
* B/96E(37) and B/SRT were the most cytotoxic preparations
* B/96E(37) are most active against Lewis lung carcinoma (LL/2) [IC(50) =25.06 μg/ml], cervical carcinoma (KB) [IC(50) =35.69 μg/ml] and colon adenocarcinoma (SW707) [IC(50) =49.06 μg/ml].
* B/SRT was especially effective in inhibiting proliferation of cervical carcinoma (KB) [IC(50) =23.57 μg/ml], breastcarcinoma (MCF-7) [IC(50) =29.86 μg/ml] and lung carcinoma (A-549) [IC(50) =40.03 μg/ml].
* In animal studies on mice bearing Lewis lung carcinoma showed significant inhibition of tumor growth by B/W(37) administered for 21 days at daily doses of 5 and 0.5 mg (p=0.0009).
* There are no adverse effects in all preparations.
The results suggested that Cat's claw is effective against cancer through its cytotoxicity, however, the cancer cells inhibition is totally depending on the dose of concentrations.
Furthermore, in the study to reaffirm the traditional use of the preparations from Uncaria tomentosa, a South American Rubiaceae, for the treatment of infective, inflammatory and tumoral processes, researchers launched an investigation to test whether the pentacyclic oxindole alkaloid mitraphylline isolated from the dried inner bark of this plant species has a similar anti-cancer effect in human Ewing's sarcoma MHH-ES-1 and breast cancer MT-3 cell lines.
Administration at the IC (50) +/- SE values of17.15 +/- 0.82 microM for MHH-ES-1 and 11.80 +/- 1.03 microM for MT-3 for 30 hours exerted a clinically significant inhibition of the human sarcoma and breast cancer cell line in a dose-dependent manner.
The finding suggested that Cat's claw may have a chemotherapeutic effect in the prevention and treatment of cancer without inducing any adverse effects.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the preparations during the course of the disease will be necessary to complete the picture of Cat's claw anti-cancers possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Topical plant database (Rain tree)
(2) Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition by Pilarski R, Filip B, Wietrzyk J, Kuraś M, Gulewicz K.(PubMed)
(3) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines, by García Giménez D, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)
(4) Environmental Factors Inducing Human Cancers by N Parsa. (PMC)
(5) Cancer is a Preventable Disease that Requires Major Lifestyle Changes by Preetha Anand, Ajaikumar B. Kunnumakara, Chitra Sundaram, Kuzhuvelil B. Harikumar,Sheeja T. Tharakan, Oiki S. Lai, Bokyung Sung, and Bharat B. Aggarwal. (PMC)
Cancers are a class of chronic diseases associated with cell growth in the tissue and organs. At the advanced stage, malignant cells can travel a distance away from the original site to infect other healthy cells and tissues.
There are many types of cancer, depending on the location where cancer begins.
As of today, researchers do not know what are the exact cause of cancers. however many researchers believe, exposure to environmental toxins, genetic mutation, and an unhealthy diet and lifestyle are the most common risk factors associated with the onset of the diseases.
Genetic mutation od BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancer and alternation of gene PTEN.that suppress the growth of tumors also increase the risk of cancers.
Dr. N Parsa in the study "Environmental Factors Inducing Human Cancers" wrote, "(Environment toxins cause) genetic mutations that would eventually alter the normal pathway of cellular proliferation and differentiation. Genetic mutations in four groups of genes; (Oncogenes, Tumor suppressor genes, Apoptosis genes, and DNA repair genes) play a vital role in altering the normal cell division" and " Inhibition of carcinogenic exposures wherever possible should be the goal of cancer prevention programs to reduce exposures from all environmental carcinogens".
The statement illustrated that environmentally induced genetic alternation at the cellular levels can initiate the early onset of cancer.
According to the World Cancer Research Fund UK What you eat can have a big impact on your risk of developing cancer. eating too much fat and sugar and less of fruits and vegetables are the most prevalent risk factors of cancers.
Truly, "Cancer is a Preventable Disease that Requires Major Lifestyle Changes", Dr. Preetha Anand, the lead scientist in the medical literature said, "Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle" and "cancer prevention requires smoking cessation, increased ingestion of fruits and vegetables, moderate use of alcohol, caloric restriction, exercise, avoidance of direct exposure to sunlight, minimal meat consumption, use of whole grains, use of vaccinations, and regular check-ups".
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The Chemical Ingredients
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchona, corynantheine, corynoxeine, daucosterol, epicatechin, harman, hirsuteine, hirsutine, iso-pteropodine.
In the study of anti-cancer effect of the preparation Cat's claw in several cancer cell lines to determine the IC (50) values with different quantitative and qualitative oxindole alkaloid composition: B/W(37) --bark extracted in water at 37 °C, B/W(b)--bark extracted in boiling water, B/50E(37) --bark extracted in 50% ethanol at 37 °C, B/E(b)--bark extracted in boiling 96% ethanol, B/96E(37) --bark extracted in 96% ethanol at 37 °C and B/SRT--bark extracted in water and dichloromethane researchers found that
* A high correlation between the total oxindole alkaloid content (from 0.43% to 50.40% d.m.) and the antiproliferative activity of the preparations (IC(50) from >1000 μg/ml to 23.57 μg/ml).
* B/96E(37) and B/SRT were the most cytotoxic preparations
* B/96E(37) are most active against Lewis lung carcinoma (LL/2) [IC(50) =25.06 μg/ml], cervical carcinoma (KB) [IC(50) =35.69 μg/ml] and colon adenocarcinoma (SW707) [IC(50) =49.06 μg/ml].
* B/SRT was especially effective in inhibiting proliferation of cervical carcinoma (KB) [IC(50) =23.57 μg/ml], breastcarcinoma (MCF-7) [IC(50) =29.86 μg/ml] and lung carcinoma (A-549) [IC(50) =40.03 μg/ml].
* In animal studies on mice bearing Lewis lung carcinoma showed significant inhibition of tumor growth by B/W(37) administered for 21 days at daily doses of 5 and 0.5 mg (p=0.0009).
* There are no adverse effects in all preparations.
The results suggested that Cat's claw is effective against cancer through its cytotoxicity, however, the cancer cells inhibition is totally depending on the dose of concentrations.
Furthermore, in the study to reaffirm the traditional use of the preparations from Uncaria tomentosa, a South American Rubiaceae, for the treatment of infective, inflammatory and tumoral processes, researchers launched an investigation to test whether the pentacyclic oxindole alkaloid mitraphylline isolated from the dried inner bark of this plant species has a similar anti-cancer effect in human Ewing's sarcoma MHH-ES-1 and breast cancer MT-3 cell lines.
Administration at the IC (50) +/- SE values of17.15 +/- 0.82 microM for MHH-ES-1 and 11.80 +/- 1.03 microM for MT-3 for 30 hours exerted a clinically significant inhibition of the human sarcoma and breast cancer cell line in a dose-dependent manner.
The finding suggested that Cat's claw may have a chemotherapeutic effect in the prevention and treatment of cancer without inducing any adverse effects.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the preparations during the course of the disease will be necessary to complete the picture of Cat's claw anti-cancers possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Topical plant database (Rain tree)
(2) Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition by Pilarski R, Filip B, Wietrzyk J, Kuraś M, Gulewicz K.(PubMed)
(3) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines, by García Giménez D, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)
(4) Environmental Factors Inducing Human Cancers by N Parsa. (PMC)
(5) Cancer is a Preventable Disease that Requires Major Lifestyle Changes by Preetha Anand, Ajaikumar B. Kunnumakara, Chitra Sundaram, Kuzhuvelil B. Harikumar,Sheeja T. Tharakan, Oiki S. Lai, Bokyung Sung, and Bharat B. Aggarwal. (PMC)
Herbal Catnip (Nepeta cataria) on Memory
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia. It has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, colds and flu, skin irritation stimulates sweating, promotes menstruation, etc..
The central nervous system include is the part of the nervous system of the brain and spinal cord with the function of integrates information it receives from for the entire nervous system, and control all the workings of your body.
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.
The Benefits
Evidence emerged in the research community that certain ingredients plants and vegetables may improve the cognitive function by enhancing their antioxidant activity. Study of the effects of methods aqueous extract on memory retention and retrieval of mice using passive avoidance apparatus, the result showed that the extract has exerted its antioxidant effect by enhancing the memory retention and retrieval, these may be a result of the effects of the herb's rosmarinic acid, caffeic acid, and phenolic acids.
Side effects
1. Overdose of Catnip may cause central nervous system depression.
2. Long-term exposure induced tolerance to stereotypic behavior, catalepsy and sleeping time, and increased susceptibility to seizures.
3. Catnip may interact with other medication if used on a daily basis
4. Etc.
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections by Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi, and Reza Khashei(PubMed)
(2) Effects of Nepeta menthoides aqueous extract on retention and retrieval of memory in mice by Sarahroodi S, Jafari-Najafi R, Nasri S, Rohampour K, Maleki-Jamshid A, Esmaeili S.(PubMed)
(3) Investigation of the chemical composition-antibacterial activityrelationship of essential oils by chemometric methods, by Miladinović DL, Ilić BS, Mihajilov-Krstev TM, Nikolić ND, Miladinović LC, Cvetković OG.(PubMed)
(4) Croton zehntneri: possible central nervous system effects of the essential oil in rodents`by Batatinha MJ, de Souza-Spinosa H, Bernardi MM(PubMed)
(5) `Behavioral effects of acute and long-term administration of catnip (Nepeta cataria) in mice`by Massoco CO, Silva MR, Gorniak SL, Spinosa MS, Bernardi MM(PubMed)
The central nervous system include is the part of the nervous system of the brain and spinal cord with the function of integrates information it receives from for the entire nervous system, and control all the workings of your body.
Ingredients
Besides the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.
The Benefits
Evidence emerged in the research community that certain ingredients plants and vegetables may improve the cognitive function by enhancing their antioxidant activity. Study of the effects of methods aqueous extract on memory retention and retrieval of mice using passive avoidance apparatus, the result showed that the extract has exerted its antioxidant effect by enhancing the memory retention and retrieval, these may be a result of the effects of the herb's rosmarinic acid, caffeic acid, and phenolic acids.
Side effects
1. Overdose of Catnip may cause central nervous system depression.
2. Long-term exposure induced tolerance to stereotypic behavior, catalepsy and sleeping time, and increased susceptibility to seizures.
3. Catnip may interact with other medication if used on a daily basis
4. Etc.
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections by Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi, and Reza Khashei(PubMed)
(2) Effects of Nepeta menthoides aqueous extract on retention and retrieval of memory in mice by Sarahroodi S, Jafari-Najafi R, Nasri S, Rohampour K, Maleki-Jamshid A, Esmaeili S.(PubMed)
(3) Investigation of the chemical composition-antibacterial activityrelationship of essential oils by chemometric methods, by Miladinović DL, Ilić BS, Mihajilov-Krstev TM, Nikolić ND, Miladinović LC, Cvetković OG.(PubMed)
(4) Croton zehntneri: possible central nervous system effects of the essential oil in rodents`by Batatinha MJ, de Souza-Spinosa H, Bernardi MM(PubMed)
(5) `Behavioral effects of acute and long-term administration of catnip (Nepeta cataria) in mice`by Massoco CO, Silva MR, Gorniak SL, Spinosa MS, Bernardi MM(PubMed)
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