Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
Intake of cinnamon may induce an immunomodulatory effect in regular immune function against certain diseases such as autoimmunity. According to the Kyung Hee University, water extract of cinnamon bark (CWE) exerted the effect on cytokine secretion and activation of T cells.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections.
Sodium benzoate (NaB), a metabolite of cinnamon ameliorated clinical symptoms and disease progression of allergic encephalomyelitis caused by immune overreaction induced inflammation, through enriched regulatory T cell population, and down-regulated the expression of various contact molecules in T cells.
Dr. Pahan K said, "Sodium benzoate (NaB), a metabolite of cinnamon and an FDA-approved drug against urea cycle disorders in children, ......, regulates many immune signaling pathways responsible for inflammation, glial cell activation, switching of T-helper cells, modulation of regulatory T cells, cell-to-cell contact, and migration"
Orofacial granulomatosis (OFG) is a chronic inflammatory disorder with symptoms of inflammation such as lip swelling but also affecting gingivae, buccal mucosa, the floor of the mouth,.....
cinnamon- and benzoate-free diet, after 8 weeks of treatment, significantly improve both lips and oral site.
Furthermore, the experiment of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) on human skin cells showed strong anti-proliferative effects on skin cells and significantly inhibited the production of several inflammatory biomarkers expressed by autoimmunity.
Cinnamon may improve immune expression and reduce risk of autoimmune diseases, intake of the whole herb should be taken with care in the prevention of toxicity
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation by Lee BJ1, Kim YJ, Cho DH, Sohn NW, Kang H.(PubMed)
(2) Immunomodulation of experimental allergic encephalomyelitis by cinnamon metabolite sodium benzoate by Pahan K1.(PubMed)
(3) Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis by Brahmachari S1, Pahan K.(PubMed)
(4) Improvement in orofacial granulomatosis on a cinnamon- and benzoate-free diet by White A1, Nunes C, Escudier M, Lomer MC, Barnard K, Shirlaw P, Challacombe SJ, Sanderson JD.(PubMed)
Sunday, December 1, 2019
Herbal Coltsfoot(Tussilago farfara) Protects the Lung Against Tuberculosis (TB)
The lung is a vital organ located near the backbone on either side of the heart with major functions to inhale oxygen from the air to the bloodstream that nourishes the body cells and exhale carbon dioxide from the bloodstream.
Other functions of the lung are to maintain the right levels of pH, filter out blood clots, protect the heart against shock, infection, and speech.
Tuberculosis (TB) is a contagious disease caused by bacteria called Mycobacterium tuberculosis.
The bacteria attacked the lung tissue, leading to the significantly reduced function of the lung in the inhaling and exhaling.
The disease is also found to cause major damage to other parts of the body.
According to statistics, 25% of the world's population is infected with TB. In 2016, 10.4 million people around the world became sick with the disease-inducing the death of 1.7 million people.
The most common signs and symptoms of TB are associated with reduced lung function, including coughing that lasts a long period of time, coughing up blood, chest pain, particularly in breathing or coughing, fatigue, fever, night sweats, and chills.
Some patients may also experience symptoms of unintended weight loss.
Conventionally, the length of treatment of TB depending on the severity of the disease takes longer compared to other infections with at least six months of antibiotics intake, including Isoniazid, Rifampin (Rifadin, Rimactane) and Ethambutol (Myambutol).
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belongings to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound that processes antitubercular activity, researchers examined the effect of Arctium lappa and Tussilago farfara extracts for activity against Mycobacterium tuberculosis.
In Mycobacterium tuberculosis H37Rv, according to the tested analysis, the ethyl acetate extract of Tussilago farfara displayed antitubercular activity with a MIC of 62.5 μg/mL.
The anti-tuberculosis property of Tussilago farfara against the Mycobacterium tuberculosis H37Rv was attributed to the compounds including mixture of β sitosterol/stigmasterol (4), trans-caffeic acid (7), kaempferol (8), quercetin (9), kaempferol-3-O-glucoside (10), loliolide (11), a (4:1) mixture of p-coumaric acid/4-hydroxybenzoic acid (12), p-coumaric acid (13). in the extract.
In compound comparison, the best anti-tuberculosis activity was observed in the p-coumaric acid (13) (MIC 31.3 μg/mL or 190.9 μM) alone and in mixture with 4-hydroxybenzoic acid (12) (MIC 62.5 μg/mL).
Based on the findings, researchers aid, "The above results provide for the first time some scientific evidence to support, to some extent, the ethnomedicinal use of Arctium lappa and Tussilago farfara as traditional antitubercular remedies.".
Taken altogether, coltsfoot may be considered a remedy for the treatment of tuberculosis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents by Zhao J1, Evangelopoulos D2, Bhakta S2, Gray AI1, Seidel V. (PubMed)
Other functions of the lung are to maintain the right levels of pH, filter out blood clots, protect the heart against shock, infection, and speech.
Tuberculosis (TB) is a contagious disease caused by bacteria called Mycobacterium tuberculosis.
The bacteria attacked the lung tissue, leading to the significantly reduced function of the lung in the inhaling and exhaling.
The disease is also found to cause major damage to other parts of the body.
According to statistics, 25% of the world's population is infected with TB. In 2016, 10.4 million people around the world became sick with the disease-inducing the death of 1.7 million people.
The most common signs and symptoms of TB are associated with reduced lung function, including coughing that lasts a long period of time, coughing up blood, chest pain, particularly in breathing or coughing, fatigue, fever, night sweats, and chills.
Some patients may also experience symptoms of unintended weight loss.
Conventionally, the length of treatment of TB depending on the severity of the disease takes longer compared to other infections with at least six months of antibiotics intake, including Isoniazid, Rifampin (Rifadin, Rimactane) and Ethambutol (Myambutol).
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belongings to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound that processes antitubercular activity, researchers examined the effect of Arctium lappa and Tussilago farfara extracts for activity against Mycobacterium tuberculosis.
In Mycobacterium tuberculosis H37Rv, according to the tested analysis, the ethyl acetate extract of Tussilago farfara displayed antitubercular activity with a MIC of 62.5 μg/mL.
The anti-tuberculosis property of Tussilago farfara against the Mycobacterium tuberculosis H37Rv was attributed to the compounds including mixture of β sitosterol/stigmasterol (4), trans-caffeic acid (7), kaempferol (8), quercetin (9), kaempferol-3-O-glucoside (10), loliolide (11), a (4:1) mixture of p-coumaric acid/4-hydroxybenzoic acid (12), p-coumaric acid (13). in the extract.
In compound comparison, the best anti-tuberculosis activity was observed in the p-coumaric acid (13) (MIC 31.3 μg/mL or 190.9 μM) alone and in mixture with 4-hydroxybenzoic acid (12) (MIC 62.5 μg/mL).
Based on the findings, researchers aid, "The above results provide for the first time some scientific evidence to support, to some extent, the ethnomedicinal use of Arctium lappa and Tussilago farfara as traditional antitubercular remedies.".
Taken altogether, coltsfoot may be considered a remedy for the treatment of tuberculosis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents by Zhao J1, Evangelopoulos D2, Bhakta S2, Gray AI1, Seidel V. (PubMed)
Saturday, November 30, 2019
Herbal Catnip Essential Oil, The Natural Antibiotic Alternative with No Side Effects
Herbal catnip was found to process certain chemical compounds that stimulate the immune function against microbial organisms in the acute and chronic phase of infection, some scientists suggested.
In human, anti-microbial activity is a natural reaction in which the macrophages of the immune system in the response to the early phase of infection stimulate the production of inflammatory cytokines which have a unique function in killing off foreign pathogens before they can cause harm to the body.
In plants, antimicrobial substances produced by the plant are served as plant defense mechanisms against predation by microorganisms.
However, overproduction of proinflammatory cytokines in many cases can mistakenly cause damage to healthy cells and tissue in the site of infection, leading to abnormal skin and scars formation.
There are 2 types of inflammatory cytokines: the proinflammatory (Isuch as IL-1β, IL-6. and TNF-α) and anti-inflammatory (such as IL-4, IL-6, IL-10, and IL-11) cytokines. Some cytokines process a duo inflammatory (such as IL-6) functions, under normal conditions, they act as the anti-inflammatory agents to protect against inflammation. Once they sense the danger to the body, they can quickly switch to pro-inflammatory cytokines.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.
The functional herb has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation, stimulate sweating, promote menstruation, etc..
Ingredients
Besides, having the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.
In the finding of the natural alternatives in replacement of traditional antibiotics with no side effects, researchers at the Shiraz University of Medical Sciences launched an evaluation to examine the antimicrobial activity of the essential oil derived from herbal Catnip.
Chemical 4a-α, 7-α, 7a-β-nepetalactone (55-58%), and 4a-α, 7-β, 7a-α-nepetalactone (30-31.2%) isolated from the essential oil were effective in exerting their antimicrobial activity against all tested bacteria at concentrations of 0.125-4 μL/mL and the growth of Candida species at a concentration less than 1 μL/mL.
The essential oil chemical constituent nepetalactones are also found to process anti antibacterial, antifungal, insecticidal and antioxidant activities.
Terpenenes or terpenoids found abundant in Catnip are active against bacteria, fungi, viruses, and protozoa. According to the 1977 report, 60% of essential oil derivatives derived from terpenoids demonstrated inhibition of fungi and while only 30% inhibited bacteria.
Furthermore, the extract of catnip also displayed an inhibitory activity on growth, enzyme production and adhesion of some bacteria.
Moreover, the essential oil extract from Catnip also exhibited the anti bactericidal activity against Gram-positive bacteria at concentrations ranging from 0.5 to 8 μL/mL.
All of the Gram-negative bacteria were susceptible to the Catnip oils at concentrations of 0.25–32 μL/mL
The essential oil of Catnip from different growth stages exhibited bacteriostatic and bactericidal activities against the Shigella and Salmonella species at concentrations of 0.25–2 μL/mL and 0.5–8 μL/mL, respectively.
Additionally, the essential oil inhibited the growth of the standard species of Aspergillus at a concentration of 0.25–1 μL/mL.
In the comparison of the antibacterial effect of some herbs, including Catnip, researchers found that Lavender oil is more effective in the exhibited antibacterial ability than the Catnip essential oil, probably based on the concept of synergistic values of essential oil components.
Nevertheless, only a few published reports are available regarding the antimicrobial effects of the catnip EOs, especially against food-borne and resistant microorganisms, Dr. Zomorodian K, the lead author suggested.
Taken altogether, the essential oil derived from catnip may be considered an adjunct therapy for the treatment of microbial infection.
Today, mainstream medicine antibiotics have become less effective as many viral and bacteria have developed resistance to the application due to being overused.
Secondary metabolites of plants processed antimicrobial properties with no side effects have been promoted by some companies as natural alternatives to antibiotics. The general public must be aware that many of these compounds are currently available as unregulated botanical preparations.
Please make sure that you follow the guideline of the product closely, as acute liver toxicity has been reported in some cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections by Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi, and Reza Khashei(PubMed)
(2) Effects of Nepeta menthoides aqueous extract on retention and retrieval of memory in mice by Sarahroodi S, Jafari-Najafi R, Nasri S, Rohampour K, Maleki-Jamshid A, Esmaeili S.(PubMed)
In human, anti-microbial activity is a natural reaction in which the macrophages of the immune system in the response to the early phase of infection stimulate the production of inflammatory cytokines which have a unique function in killing off foreign pathogens before they can cause harm to the body.
In plants, antimicrobial substances produced by the plant are served as plant defense mechanisms against predation by microorganisms.
However, overproduction of proinflammatory cytokines in many cases can mistakenly cause damage to healthy cells and tissue in the site of infection, leading to abnormal skin and scars formation.
There are 2 types of inflammatory cytokines: the proinflammatory (Isuch as IL-1β, IL-6. and TNF-α) and anti-inflammatory (such as IL-4, IL-6, IL-10, and IL-11) cytokines. Some cytokines process a duo inflammatory (such as IL-6) functions, under normal conditions, they act as the anti-inflammatory agents to protect against inflammation. Once they sense the danger to the body, they can quickly switch to pro-inflammatory cytokines.
Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.
The functional herb has been used in herbal medicine as an insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritation, stimulate sweating, promote menstruation, etc..
Ingredients
Besides, having the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.
In the finding of the natural alternatives in replacement of traditional antibiotics with no side effects, researchers at the Shiraz University of Medical Sciences launched an evaluation to examine the antimicrobial activity of the essential oil derived from herbal Catnip.
Chemical 4a-α, 7-α, 7a-β-nepetalactone (55-58%), and 4a-α, 7-β, 7a-α-nepetalactone (30-31.2%) isolated from the essential oil were effective in exerting their antimicrobial activity against all tested bacteria at concentrations of 0.125-4 μL/mL and the growth of Candida species at a concentration less than 1 μL/mL.
The essential oil chemical constituent nepetalactones are also found to process anti antibacterial, antifungal, insecticidal and antioxidant activities.
Terpenenes or terpenoids found abundant in Catnip are active against bacteria, fungi, viruses, and protozoa. According to the 1977 report, 60% of essential oil derivatives derived from terpenoids demonstrated inhibition of fungi and while only 30% inhibited bacteria.
Furthermore, the extract of catnip also displayed an inhibitory activity on growth, enzyme production and adhesion of some bacteria.
Moreover, the essential oil extract from Catnip also exhibited the anti bactericidal activity against Gram-positive bacteria at concentrations ranging from 0.5 to 8 μL/mL.
All of the Gram-negative bacteria were susceptible to the Catnip oils at concentrations of 0.25–32 μL/mL
The essential oil of Catnip from different growth stages exhibited bacteriostatic and bactericidal activities against the Shigella and Salmonella species at concentrations of 0.25–2 μL/mL and 0.5–8 μL/mL, respectively.
Additionally, the essential oil inhibited the growth of the standard species of Aspergillus at a concentration of 0.25–1 μL/mL.
In the comparison of the antibacterial effect of some herbs, including Catnip, researchers found that Lavender oil is more effective in the exhibited antibacterial ability than the Catnip essential oil, probably based on the concept of synergistic values of essential oil components.
Nevertheless, only a few published reports are available regarding the antimicrobial effects of the catnip EOs, especially against food-borne and resistant microorganisms, Dr. Zomorodian K, the lead author suggested.
Taken altogether, the essential oil derived from catnip may be considered an adjunct therapy for the treatment of microbial infection.
Today, mainstream medicine antibiotics have become less effective as many viral and bacteria have developed resistance to the application due to being overused.
Secondary metabolites of plants processed antimicrobial properties with no side effects have been promoted by some companies as natural alternatives to antibiotics. The general public must be aware that many of these compounds are currently available as unregulated botanical preparations.
Please make sure that you follow the guideline of the product closely, as acute liver toxicity has been reported in some cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections by Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi, and Reza Khashei(PubMed)
(2) Effects of Nepeta menthoides aqueous extract on retention and retrieval of memory in mice by Sarahroodi S, Jafari-Najafi R, Nasri S, Rohampour K, Maleki-Jamshid A, Esmaeili S.(PubMed)
Herbal Cinnamon, The Kitchen Spice in Prevention and Treatment of Alzheimer's Diseases
Adding spicy cinnamon into your diet may have a significant effect of blocking the onset of Alzheimer's Diseases, a new study suggested.
Although cinnamon is best known for its anti-diabetic effect, The spices also consist of certain chemical constituents associated to prevent insulin resistance(2).
The herb has been used in folk medicine as anti-fungal and bacterial agents and to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(3).
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life.
Alzheimer's gets worse over time, and it is fatal.
According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.
The exact causes of Alzheimer's disease are unknown. However, some researchers suggested that certain risk factors such as cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions and psychosocial factors (high education, active social engagement, physical exercise, and mentally stimulating activity) are associated to the onset of the disease(10).
Some researchers suggested that people who are following lifelong intake of Western diet and at higher risk due to family history should be aware of some early signs and symptoms such as memory loss, the difficulty of planning and solving problems, completing familiar tasks, determining time or place, finding the right words, misplacing items often. ... and difficulty making decisions.
If you experience some signs and symptoms above, please make sure to check with your doctor to rule out the possibility.
In insulin resistance Winstar male rats induced by high fat/high fructose (HF/HFr), researchers found that injection of cinnamon (CN) alleviates the increases of mRNA associated with Alzheimer's such as PTEN, Tau, and amyloid precursor protein, through its neuroprotective activity associated with improved whole-body insulin sensitivity and related changes in the brain.(4).
Cinnamon aqueous extract also found to have the ability to inhibit tau aggregation in vitro and even induce dissociation of tangles isolated from AD brain, as well as sequestering highly reactive and toxic byproducts of oxidation, through protecting tau from abnormal modifications, according to the University of California(5).
PTEN, is a tumor suppressor gene involved in the regulation of the cell cycle.
Tau protein found in neurons of the central nervous system, un-stabilize microtubules have been found in patients with Alzheimer's Disease.
Amyloid precursor protein plays an important role in the formation of synapses between neurons in the nervous system, showed to generate beta-amyloid (Aβ) in patients with Alzheimer's diseases
In cognitive impairment in Alzheimer's disease animal models, caused by the accumulation of soluble oligomeric assemblies of the β-amyloid polypeptide (Aβ), oral administration of the cinnamon extract (CEppt), enhanced the decrease of Aβ oligomers, reduction of plaques and improvement in cognitive behavior(6).
Some researchers suggested that the spice may be used as amyloid-beta aggregation blockers as a few approved drugs available to treat Alzheimer's disease(9) due to many potential drugs in the pipeline for the disease and other amyloid-associated illnesses may not be as promising as thought(8).
Taken altogether, cinnamon and its extract may have a protective effect in reduced risk and for treatment of Alzheimer's Diseases, through reduction of the complication causes by metabolic syndromes such as obesity and diabetes.
According to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and burning sensation in the mouth with a large amount. According to traditional Chinese medicine, overdoses of cinnamon can be toxic and damaged to the liver(1)(7).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(2) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats by Bano F1, Ikram H2, Akhtar N3.(PubMed)
(3) @Popular Herbs -Cinnamon
(4) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes by Anderson RA1, Qin B2, Canini F3, Poulet L4, Roussel AM(PubMed)
(5) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis by George RC1, Lew J, Graves DJ. (PubMed)
(6) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(7) Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult by Kim DS1, Kim JY, Han YS. (PubMed)
(8) Amyloid blockers may be a dead end(The scientist)
(9) Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy by Guo JP1, Yu S, McGeer PL. (PubMed)
(10) Alzheimer's disease in Foods Points of View(General health)
Although cinnamon is best known for its anti-diabetic effect, The spices also consist of certain chemical constituents associated to prevent insulin resistance(2).
The herb has been used in folk medicine as anti-fungal and bacterial agents and to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(3).
Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life.
Alzheimer's gets worse over time, and it is fatal.
According to statistic, over 25 million people in the world today are affected by dementia and most are suffering from Alzheimer's disease.
The exact causes of Alzheimer's disease are unknown. However, some researchers suggested that certain risk factors such as cigarette smoking, midlife high blood pressure and obesity, diabetes, and cerebrovascular lesions and psychosocial factors (high education, active social engagement, physical exercise, and mentally stimulating activity) are associated to the onset of the disease(10).
Some researchers suggested that people who are following lifelong intake of Western diet and at higher risk due to family history should be aware of some early signs and symptoms such as memory loss, the difficulty of planning and solving problems, completing familiar tasks, determining time or place, finding the right words, misplacing items often. ... and difficulty making decisions.
If you experience some signs and symptoms above, please make sure to check with your doctor to rule out the possibility.
In insulin resistance Winstar male rats induced by high fat/high fructose (HF/HFr), researchers found that injection of cinnamon (CN) alleviates the increases of mRNA associated with Alzheimer's such as PTEN, Tau, and amyloid precursor protein, through its neuroprotective activity associated with improved whole-body insulin sensitivity and related changes in the brain.(4).
Cinnamon aqueous extract also found to have the ability to inhibit tau aggregation in vitro and even induce dissociation of tangles isolated from AD brain, as well as sequestering highly reactive and toxic byproducts of oxidation, through protecting tau from abnormal modifications, according to the University of California(5).
PTEN, is a tumor suppressor gene involved in the regulation of the cell cycle.
Tau protein found in neurons of the central nervous system, un-stabilize microtubules have been found in patients with Alzheimer's Disease.
Amyloid precursor protein plays an important role in the formation of synapses between neurons in the nervous system, showed to generate beta-amyloid (Aβ) in patients with Alzheimer's diseases
In cognitive impairment in Alzheimer's disease animal models, caused by the accumulation of soluble oligomeric assemblies of the β-amyloid polypeptide (Aβ), oral administration of the cinnamon extract (CEppt), enhanced the decrease of Aβ oligomers, reduction of plaques and improvement in cognitive behavior(6).
Some researchers suggested that the spice may be used as amyloid-beta aggregation blockers as a few approved drugs available to treat Alzheimer's disease(9) due to many potential drugs in the pipeline for the disease and other amyloid-associated illnesses may not be as promising as thought(8).
Taken altogether, cinnamon and its extract may have a protective effect in reduced risk and for treatment of Alzheimer's Diseases, through reduction of the complication causes by metabolic syndromes such as obesity and diabetes.
According to DR. Georgakopoulou EA(7), Oral intake of Cinnamon may cause Stomatitis and burning sensation in the mouth with a large amount. According to traditional Chinese medicine, overdoses of cinnamon can be toxic and damaged to the liver(1)(7).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(2) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats by Bano F1, Ikram H2, Akhtar N3.(PubMed)
(3) @Popular Herbs -Cinnamon
(4) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes by Anderson RA1, Qin B2, Canini F3, Poulet L4, Roussel AM(PubMed)
(5) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis by George RC1, Lew J, Graves DJ. (PubMed)
(6) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)
(7) Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult by Kim DS1, Kim JY, Han YS. (PubMed)
(8) Amyloid blockers may be a dead end(The scientist)
(9) Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy by Guo JP1, Yu S, McGeer PL. (PubMed)
(10) Alzheimer's disease in Foods Points of View(General health)
Herbal Cat's claw Kills 90% of Breast Cancer Cells in Vitro
Scientists may have found a functional herb which has the potential to treat breast cancer without including any side effects, some studies suggested.
Most breast cancer irregular cell growth starts on the surface of the inner linings of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).
At the later stage, after colonizing the most parts of breast tissue, malignant cells can travel a distance far way from the original site to infect other healthy tissue or organs through the fluid and blood circulation.
In Canada, the risk of getting invasive breast cancer during the lifetime before the age of 90 of a woman is 1/11.
The exact causes of breast cancer are unknown. However certain risk factors are found to associate to the early onset of the disease, including an increase in age, gender, early menstrual periods and late menopause, unhealthy diet and lifestyle, dense breast tissue,.. and genetic preposition.
However, women with the genetic mutation BRCA1 and BRCA found in 5-10% of all breast cancer cases in the United States. are at substantial risk to have breast cancer development.
According to the information provided by the University of Cambridge in the United Kingdom, out of the 3,886 women with mutation of gene BRCA1 and BRCA2 eligible for breast cancer risk analysis, 426 developed breast cancer during the study period, representing a odds relative risk ratio of 1.11.
The peak incidence of breast cancer was seen in women 41–50 years old for BRCA1 mutation carriers and those 51–60 years old for BRCA2 mutation carriers.
The cumulative risk estimates for developing breast cancer by age 80 were 72% for BRCA1 carriers and 69% for BRCA2 carriers.
Therefore, women who carry the mutation of gene BRCA1 and BRCA2 may want to take preventive measures such as intensive early surveillance, use of chemoprevention, and prophylactic surgery to the risk of breast cancer onset.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.
In the reaffirming of the use of herbal Cat's claw as anti-cancer activity in South-American folk medicine, researchers at the Istituto Nazionale per lo Studio e la Cura dei Tumori launched an investigation to examine the extract anti-breast cancer effect on a human breast cancer cell line (MCF7).
Application of the exacts display a potency in the inhibition of MCF7 through the cytostatic effects against cell growth and division in the breast cancer cell line
Furthermore, the Cat 's claw extracts a strong in antimutagenic activity by restoring the cell DNA to a healthy level.
Moreover, the extracts and fractions also exert a direct antiproliferative activity at the doses of 10 mg/ml and 20 mg/ml on an IC50 by blocking the cell division through cell cycle arrest.
Moreover, at the concentration of 100 mg/ml of two active fractions isolated from Cat's claw inhibited 90% of breast cancer cells in MCF7.
These results suggested Cat's extract and its active fractions may be considered secondary therapy for the treatment of breast cancer.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of Cat's claw anti-breast cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) The topical plant database (Raintree)
(2) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line bt Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)
Most breast cancer irregular cell growth starts on the surface of the inner linings of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).
At the later stage, after colonizing the most parts of breast tissue, malignant cells can travel a distance far way from the original site to infect other healthy tissue or organs through the fluid and blood circulation.
In Canada, the risk of getting invasive breast cancer during the lifetime before the age of 90 of a woman is 1/11.
The exact causes of breast cancer are unknown. However certain risk factors are found to associate to the early onset of the disease, including an increase in age, gender, early menstrual periods and late menopause, unhealthy diet and lifestyle, dense breast tissue,.. and genetic preposition.
However, women with the genetic mutation BRCA1 and BRCA found in 5-10% of all breast cancer cases in the United States. are at substantial risk to have breast cancer development.
According to the information provided by the University of Cambridge in the United Kingdom, out of the 3,886 women with mutation of gene BRCA1 and BRCA2 eligible for breast cancer risk analysis, 426 developed breast cancer during the study period, representing a odds relative risk ratio of 1.11.
The peak incidence of breast cancer was seen in women 41–50 years old for BRCA1 mutation carriers and those 51–60 years old for BRCA2 mutation carriers.
The cumulative risk estimates for developing breast cancer by age 80 were 72% for BRCA1 carriers and 69% for BRCA2 carriers.
Therefore, women who carry the mutation of gene BRCA1 and BRCA2 may want to take preventive measures such as intensive early surveillance, use of chemoprevention, and prophylactic surgery to the risk of breast cancer onset.
Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc..
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.
In the reaffirming of the use of herbal Cat's claw as anti-cancer activity in South-American folk medicine, researchers at the Istituto Nazionale per lo Studio e la Cura dei Tumori launched an investigation to examine the extract anti-breast cancer effect on a human breast cancer cell line (MCF7).
Application of the exacts display a potency in the inhibition of MCF7 through the cytostatic effects against cell growth and division in the breast cancer cell line
Furthermore, the Cat 's claw extracts a strong in antimutagenic activity by restoring the cell DNA to a healthy level.
Moreover, the extracts and fractions also exert a direct antiproliferative activity at the doses of 10 mg/ml and 20 mg/ml on an IC50 by blocking the cell division through cell cycle arrest.
Moreover, at the concentration of 100 mg/ml of two active fractions isolated from Cat's claw inhibited 90% of breast cancer cells in MCF7.
These results suggested Cat's extract and its active fractions may be considered secondary therapy for the treatment of breast cancer.
However, due to the limitation of the above studies, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of Cat's claw anti-breast cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) The topical plant database (Raintree)
(2) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line bt Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)
Herbal Cascara Sagrada's Emodin, the Anti Breast Cancer Bioactive Compound
Scientists may have found a natural ingredient isolated from a herbal plant which processes a significant effect in reducing the risk and treatment of breast cancer, some studies suggested.
Breast cancer (malignant breast neoplasm) is a medical and chronic condition characterized by irregular cell growth in the breast tissue.
Most cases of breast cancer start either in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases of breast cancer that start in other areas of the breast
The cause of breast cancer is the result of the alternation of DNA of the cells in the breast.
According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Genetic preposition, one of the prevalent risk factor associated with the increased risk of breast cancer has been under intensifying study in scientists over the world over a few decades ago, suggested that women who carry the mutated genes BRCA1 and 2 have 60% most likely risk to develop breast cancer before the age of 70.
Another prevalent and most mentioned risk factor associated with the risk of the disease is obesity.
Dr. Manuel Picon‐Ruiz, the lead author, in the concern of the correlated increased incidence of breast cancer among obese women launched an investigation to examine whether obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages.
After taking into account co and confounder, the doctors wrote, "The Million Women Study followed 1.2 million UK women ages 50 to 64 years for a mean of 5.4 years, including 45,037 with breast cancer, and identified a nearly 30% higher risk of developing postmenopausal breast cancer with obesity". and "(But) a large body of evidence indicates that, although obesity is inversely associated with receptor‐positive breast cancer development before menopause".
Interestingly, the results strongly indicated, obesity is a risk factor of breast cancer in postmenopause but a reduced risk factor before menopause.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal plant bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the finding a natural compound or whole food which process the potency for the treatment of breast cancer with little or no side effects compared to those of conventional chemo drug, researchers conducted a joint study led by the China Medical University to examine the anti-breast cancer effect of Emodin.
Human breast cancer cells Bcap-37 and ZR-75-30.were used in the study
The cell viability following emodin treatment was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Application of Emodin showed a strong effect in the inhibition of the growth and induction of apoptosis of breast cancer cells Bcap-37 and ZR-75-30 in a time- and dose-dependent manner.
The inhibitory activity was attributed to Emodin in reducing the level of a protein associated with inhibiting apoptosis and promoting oncogenesis, and proteins and antibodies associated with programming cell death and enhancing apoptosis.
Dr. CONG ZU the lead scientist, after taking into account co and confounders said, "These findings indicate that emodin induces growth inhibition and apoptosis in human breast cancer cells. Emodin may be a potential therapeutic agent for the treatment of breast cancer".
In mice bearing EO771 or 4T1 breast tumors, researchers at the University of South Carolina School of Medicine examine the effects of Emodin against breast cancer through varied mechanisms.
Application of Emodin showed a significant effect in the attenuation tumor growth by inhibiting macrophage infiltration and M2-like polarization, in promoting cancer cell growth, invasion, metastasis and accompanied by increased immune white blood cells in the host and reduced the new formation of blood vessels for the cancer proliferation.
The inhibition of the promotion of cancer cell growth, invasion, metastasis by emodin was associated with deactivation of genes on the promoters of M2-related genes in tumor-associated macrophages.
Dr. Iwanowycz S, at the final report, "emodin acts on both breast cancer cells and macrophages and effectively blocks the tumor-promoting feed-forward loop between the two cell types, thereby inhibiting breast cancer growth and metastasis".
Taken altogether, Herbal Cascara Sagrada processed abundant bioactive compound Emodin may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin induces apoptosis of human breast cancer cells by modulating the expression of apoptosis-related genes by CONG ZU,1,* MINGDI ZHANG,2,* HUI XUE,3 XIAOPENG CAI,4 LEI ZHAO,5 ANNING HE,1GUANGYUAN QIN,1 CHUNSHU YANG,1 and XINYU ZHENG. (PMC)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
(3) Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages by Iwanowycz S1, Wang J1, Hodge J1, Wang Y1, Yu F2, Fan D. (PubMed).
Breast cancer (malignant breast neoplasm) is a medical and chronic condition characterized by irregular cell growth in the breast tissue.
Most cases of breast cancer start either in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases of breast cancer that start in other areas of the breast
The cause of breast cancer is the result of the alternation of DNA of the cells in the breast.
According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the US alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Genetic preposition, one of the prevalent risk factor associated with the increased risk of breast cancer has been under intensifying study in scientists over the world over a few decades ago, suggested that women who carry the mutated genes BRCA1 and 2 have 60% most likely risk to develop breast cancer before the age of 70.
Another prevalent and most mentioned risk factor associated with the risk of the disease is obesity.
Dr. Manuel Picon‐Ruiz, the lead author, in the concern of the correlated increased incidence of breast cancer among obese women launched an investigation to examine whether obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages.
After taking into account co and confounder, the doctors wrote, "The Million Women Study followed 1.2 million UK women ages 50 to 64 years for a mean of 5.4 years, including 45,037 with breast cancer, and identified a nearly 30% higher risk of developing postmenopausal breast cancer with obesity". and "(But) a large body of evidence indicates that, although obesity is inversely associated with receptor‐positive breast cancer development before menopause".
Interestingly, the results strongly indicated, obesity is a risk factor of breast cancer in postmenopause but a reduced risk factor before menopause.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal plant bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the finding a natural compound or whole food which process the potency for the treatment of breast cancer with little or no side effects compared to those of conventional chemo drug, researchers conducted a joint study led by the China Medical University to examine the anti-breast cancer effect of Emodin.
Human breast cancer cells Bcap-37 and ZR-75-30.were used in the study
The cell viability following emodin treatment was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
Application of Emodin showed a strong effect in the inhibition of the growth and induction of apoptosis of breast cancer cells Bcap-37 and ZR-75-30 in a time- and dose-dependent manner.
The inhibitory activity was attributed to Emodin in reducing the level of a protein associated with inhibiting apoptosis and promoting oncogenesis, and proteins and antibodies associated with programming cell death and enhancing apoptosis.
Dr. CONG ZU the lead scientist, after taking into account co and confounders said, "These findings indicate that emodin induces growth inhibition and apoptosis in human breast cancer cells. Emodin may be a potential therapeutic agent for the treatment of breast cancer".
In mice bearing EO771 or 4T1 breast tumors, researchers at the University of South Carolina School of Medicine examine the effects of Emodin against breast cancer through varied mechanisms.
Application of Emodin showed a significant effect in the attenuation tumor growth by inhibiting macrophage infiltration and M2-like polarization, in promoting cancer cell growth, invasion, metastasis and accompanied by increased immune white blood cells in the host and reduced the new formation of blood vessels for the cancer proliferation.
The inhibition of the promotion of cancer cell growth, invasion, metastasis by emodin was associated with deactivation of genes on the promoters of M2-related genes in tumor-associated macrophages.
Dr. Iwanowycz S, at the final report, "emodin acts on both breast cancer cells and macrophages and effectively blocks the tumor-promoting feed-forward loop between the two cell types, thereby inhibiting breast cancer growth and metastasis".
Taken altogether, Herbal Cascara Sagrada processed abundant bioactive compound Emodin may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin induces apoptosis of human breast cancer cells by modulating the expression of apoptosis-related genes by CONG ZU,1,* MINGDI ZHANG,2,* HUI XUE,3 XIAOPENG CAI,4 LEI ZHAO,5 ANNING HE,1GUANGYUAN QIN,1 CHUNSHU YANG,1 and XINYU ZHENG. (PMC)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
(3) Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages by Iwanowycz S1, Wang J1, Hodge J1, Wang Y1, Yu F2, Fan D. (PubMed).
Herbal Coltsfoot Protects Intestinal Mucosal Barrier Against the Risk of Colitis
Colitis is a condition characterized by the inflammation of the inner lining of the colon.
The disease can be caused by infection, such as inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.
Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.
Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases induced both UC and CD.
The intestinal mucosal barrier is the outermost inner layer of the lining of the intestines which plays an essential role to ensure the adequate containment of undesirable luminal contents within the intestine and preserves the ability to absorb nutrients.
Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.
In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of inflammatory bowel disease (IBD), researchers examined the anti-colitis effect of Tussilagone (TSL), a major component of Tussilago farfara.
On mice subjected to acute colitis induced by dextran sulfate sodium (DSS), tussilagone showed a significant protective effect by ameliorating weight loss, and colonic inflammatory damage.
Proteins associated with pro-inflammatory cytokines such as the expression of tumor necrosis factor-α and interleukin-6 and the activity of myeloperoxidase in colonic tissues were inhibited by tussilagone-treated mice.
Furthermore, tussilagone treatment reduced the numbers of nuclear factor-kappa B (NF-κB) in the induction of cytokines and increased the numbers of nuclear factor erythroid 2-related factor 2 (Nrf2) involved the production of antioxidant enzymes in nuclei of colonic tissues.
Based on the findings, researchers said, " tussilagone treatment attenuated DSS-induced colitis in mice through inhibiting the activation of NF-κB and inducing Nrf2 pathways, indicating that tussilagone is a potent therapeutic candidate for the treatment of intestinal ".
Taken altogether, coltsfoot may be considered a remedy for the treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis by Cheon HJ1, Nam SH1, Kim JK. (PubMed)
The disease can be caused by infection, such as inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.
Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.
Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases induced both UC and CD.
The intestinal mucosal barrier is the outermost inner layer of the lining of the intestines which plays an essential role to ensure the adequate containment of undesirable luminal contents within the intestine and preserves the ability to absorb nutrients.
Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.
In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of year to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of inflammatory bowel disease (IBD), researchers examined the anti-colitis effect of Tussilagone (TSL), a major component of Tussilago farfara.
On mice subjected to acute colitis induced by dextran sulfate sodium (DSS), tussilagone showed a significant protective effect by ameliorating weight loss, and colonic inflammatory damage.
Proteins associated with pro-inflammatory cytokines such as the expression of tumor necrosis factor-α and interleukin-6 and the activity of myeloperoxidase in colonic tissues were inhibited by tussilagone-treated mice.
Furthermore, tussilagone treatment reduced the numbers of nuclear factor-kappa B (NF-κB) in the induction of cytokines and increased the numbers of nuclear factor erythroid 2-related factor 2 (Nrf2) involved the production of antioxidant enzymes in nuclei of colonic tissues.
Based on the findings, researchers said, " tussilagone treatment attenuated DSS-induced colitis in mice through inhibiting the activation of NF-κB and inducing Nrf2 pathways, indicating that tussilagone is a potent therapeutic candidate for the treatment of intestinal ".
Taken altogether, coltsfoot may be considered a remedy for the treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis by Cheon HJ1, Nam SH1, Kim JK. (PubMed)
Subscribe to:
Posts (Atom)