Green tea may have a therapeutic and positive effect in reducing risk, progression, and treatment of juvenile arthritis, some scientists suggested.
Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.
In other words, it is an autoimmune disorder caused by the immune system attacks some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.
Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.
According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.
Juvenile Arthritis shares the common symptoms of adult arthritis, including pain, stiffness, swelling, fever, skin rash and in the serious case. The condition can also cause some complications such as pericarditis, hemolytic anemia, macrophage activation syndrome (MAS), and endarteritis
In the article "Juvenile Arthritis: Early Signs and Symptoms" By Susan Bernstein wrote, "Juvenile arthritis includes many different diseases, but one common thread between them is that they can have serious, even life-threatening impacts on a young child".
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
In the investigation of the effect of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, a model for human rheumatoid arthritis with daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days, researchers at the State University of Maringá, found that treatment group expressed a significant activity in reducing the protein and lipid damage in liver, brain, and plasma, caused by ROS expression in induction of oxidation which has been found with associated to the progression of arthritis.
Injection of green tea extract also enhanced the overexpression of antioxidant defenses, found in low levels in patients with arthritis through restoration of the glutathione (GSH) associated to the important function in preventing damage to important cellular components caused by reactive oxygen species and protein thiol levels in reducing cellular oxidation through chelative and detoxified activities and improved natural antioxidant enzymes, produced by the body.
Furthermore, green tea extract also inhibited the levels of glucose 6-phosphate dehydrogenase, which is increased in the liver in patients with arthritis, one of the major risk factors for the development of arthritis.
These results suggested that the application of green tea exerted a significantly profound effect in the liver and brain of patients suffering from rheumatoid arthritis through reduced overexpression of oxidative stress in precipitated injury to lipids and proteins.
Some researchers suggested that by modifying the metabolic function in lipid and protein, green tea extract exhibited a strong protective effect in reducing the symptoms and progression of arthritis.
According to the study of University of Health System of green tea effect in patients with rheumatoid
arthritis, injection of green tea extract demonstrated a therapeutic effect in patient's synovial fibroblast of the lining tissue which surround the capsule of the joint by inhibiting the production of IL-1B, a prototypic proinflammatory cytokines in response to acute and chronic inflammation. Overexpression of IL-1B is associated with the contribution of joint damage.
Interestingly, in the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), researchers indicated that application of tea significant inhibits the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.
Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.
Due to the limitation of the study, Dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".
More importantly, in the examine some major factors in contributing juvenile arthritis, green tea rich in catechins (Healthy green tea) in animal study, green tea injection restored these biomarkers of cytokine genes (IL-1A, IL-2, IFN-alpha, FGF-alpha, TNF-alpha) to near-normal levels, thus preventing or attenuating the development of a certain type of inflammatory arthritis.
Taken all together, green tea and its bioactive polyphenols may be considered functional food for the reduction of the early onset, progression and combined with standard therapy for the treatment of juvenile and adult arthritis.
However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity has been reported in numbers of medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM. (PubMed)
(2) (Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(3) Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver by Abe K1, Ijiri M, Suzuki T, Taguchi K, Koyama Y, Isemura M.(PubMed)
Thursday, January 16, 2020
Wednesday, January 15, 2020
Herbal Turmeric the Best for the Treatment of Gout and Recurrent Gout
Gout, a painful and recurrent condition mostly effected one joint is a type of arthritis caused by uric acid building up in the blood that induces joint inflammation.
Epidemiologically, high levels of uric acid found in the body that leads to the forming of crystals are the culprit, as a result of the inability of the kidney to get rid of uric acid.
Most cases of gout are found in patients who follow the diet with a high intake of meats and seafood and foods containing higher levels of purine such as alcoholic beverages, especially beer, and drinks sweetened with fruit sugar (fructose).
Reduced intake of the aforementioned products has been found to reduce the onset of recurrence of the condition in many previous patients.
Believe it or not, most patients with gout and recurrent gout also associated with medical conditions of hypertension, renal insufficiency, and hypertriglyceridemia.
Furthermore, the increase of the level of uric acid not only significantly raises the risks of gout, but also the risk of cardiovascular disease, and type 2 diabetes.
Dr. LÁlvarez-Lario B, the lead scientist at the Hospital Universitario de Burgos wrote, "Gout is characterized not only by an increase in uric acid, eventual episodes of arthritis, and chronic joint damage but also by association with several comorbidities and increased cardiovascular risk. The adoption of healthier dietary habits may contribute to better management of uricemia and also to a reduction of associated diseases".
In other words, by a change of lifestyle and moderate exercise, gout may be manageable or preventable.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the treatment of gout with no side effect, researchers examined the effect of turmeric nanoparticles (T-NPs) against gout, in vitro and in vivo.
The T-NPs developed were about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI).
In mice induced gout by monosodium urate crystals, T-NPs administered orally showed a significant effect in the treatment of gout and gout symptoms with 5, 10, and 20 ppm.
All parameters associated with the development of gout were inhibited by the injection T-NPs regardless of doses.
In other words, T-NPs inhibited gout by improving the lipid profile, renal, and liver function involved in the expression of the levels of uric acid, observed by the tested assays.
Dr. the lead scientist said, "Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management".
Taken altogether, turmeric in the form of turmeric nanoparticles (T-NPs) may be used for the treatment of gout, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug.
Kiyani MM1, Sohail MF2,3, Shahnaz G4, Rehman H5, Akhtar MF6, Nawaz I7, Mahmood T8 bt Manzoor M9, Bokhari SAI. (PubMed)
(2) [Hyperuricemia and gout; the role of diet].[Article in Spanish; Abstract available in Spanish from the publisher] by bÁlvarez-Lario B1, Alonso-Valdivielso JL2. (PubMed)
Epidemiologically, high levels of uric acid found in the body that leads to the forming of crystals are the culprit, as a result of the inability of the kidney to get rid of uric acid.
Most cases of gout are found in patients who follow the diet with a high intake of meats and seafood and foods containing higher levels of purine such as alcoholic beverages, especially beer, and drinks sweetened with fruit sugar (fructose).
Reduced intake of the aforementioned products has been found to reduce the onset of recurrence of the condition in many previous patients.
Believe it or not, most patients with gout and recurrent gout also associated with medical conditions of hypertension, renal insufficiency, and hypertriglyceridemia.
Furthermore, the increase of the level of uric acid not only significantly raises the risks of gout, but also the risk of cardiovascular disease, and type 2 diabetes.
Dr. LÁlvarez-Lario B, the lead scientist at the Hospital Universitario de Burgos wrote, "Gout is characterized not only by an increase in uric acid, eventual episodes of arthritis, and chronic joint damage but also by association with several comorbidities and increased cardiovascular risk. The adoption of healthier dietary habits may contribute to better management of uricemia and also to a reduction of associated diseases".
In other words, by a change of lifestyle and moderate exercise, gout may be manageable or preventable.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the treatment of gout with no side effect, researchers examined the effect of turmeric nanoparticles (T-NPs) against gout, in vitro and in vivo.
The T-NPs developed were about 46 nm in size with a positive zeta potential +29.55 ± 3.44 and low polydispersity index (PDI).
In mice induced gout by monosodium urate crystals, T-NPs administered orally showed a significant effect in the treatment of gout and gout symptoms with 5, 10, and 20 ppm.
All parameters associated with the development of gout were inhibited by the injection T-NPs regardless of doses.
In other words, T-NPs inhibited gout by improving the lipid profile, renal, and liver function involved in the expression of the levels of uric acid, observed by the tested assays.
Dr. the lead scientist said, "Uric acid levels were significantly reduced after the treatment with T-NPs. indicating that T-NPs show superior potential against gout management".
Taken altogether, turmeric in the form of turmeric nanoparticles (T-NPs) may be used for the treatment of gout, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug.
Kiyani MM1, Sohail MF2,3, Shahnaz G4, Rehman H5, Akhtar MF6, Nawaz I7, Mahmood T8 bt Manzoor M9, Bokhari SAI. (PubMed)
(2) [Hyperuricemia and gout; the role of diet].[Article in Spanish; Abstract available in Spanish from the publisher] by bÁlvarez-Lario B1, Alonso-Valdivielso JL2. (PubMed)
Green Tea, The Beverage In the Alleviated Symptoms, Reduces Risk and Treatment of Polymyalgia Rheumatica (PMR)
Green tea may have a therapeutic and positive effect in reducing the symptoms, risk, progression, and treatment of
Polymyalgia rheumatica an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.
The exact causes of polymyalgia rheumatica are unknown. However, researchers do know that certain prevalent risk factors are associated with the onset of diseases, such as age, family history, gender, ethnicity and exposure to environmental weather.
Genetic mutations inherited from the parents are also the major risk factor for the development of polymyalgia arthritis such as ICAM-1 (intercellular adhesion molecule 1), RANTES (regulated upon activation, normal T cell expressed, and presumably secreted).
It is important to know that Giant cell arteritis (GCA) (temporal arteritis) and polymyalgia rheumatica (PMR) share the common identity, frequently related conditions in people generally over 50 years of age, according to the Dr. Miguel A Gonzalez-Gay in the study of " Genetic epidemiology: Giant cell arteritis and polymyalgia rheumatica".
Symptoms of PMR are depending on the severity of the condition, including aches or pain shoulders, neck, upper arms, buttocks, hips or thighs, and stiffness in affected areas.
People with PMR also experience pain in the morning or after being inactive for a time, limited range of motion in the affected areas.
If you have some of the above symptoms, please check with your doctor to rule out the PMR possibility.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
In an animal study of inflammatory diseases induced by injection of LPS, researchers found that application of green tea bioactive polyphenols EGCG improves antioxidant status of the host and decreases the production of inflammatory factors, including PMR through its antioxidant properties.
Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, swelling of the infectious site without affecting the function of immune system in the protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.
The bioactive compound also inhibited reactive oxygen species (ROS) in stimulating the production of inflammatory cytokines through stopping the free radicals chain reactions that facilitate inflammation and the precipitate skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue.
In fact, overproduction of ROS increased expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases can cause an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.
The further evaluation suggested that green tea EGCG also reduced expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.
Long-term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complications of several chronic inflammatory diseases through the generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,
Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in the regulation of innate and adaptive immune functions and served as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor alpha (TNF-α) in promoting muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.
Importantly, application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.
These actions together with antioxidant initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues and prevented muscle tension to precipitate polymyalgia arthritis.
Deficiency of glutathione levels was found to associate to the early onset of polymyalgia rheumatica, inducing symptoms of pain, stiffness, achiness, fatigue, and fever.
Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drugs with the function to target pro-inflammation cytokines in the relieved stiffness and pain in patients with polymyalgia arthritis.
Taken all together, green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression and treatment of polymyalgia rheumatica(PMR).
However, ingestion green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3. (PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM. (PubMed)
Healthy Food Tomatoes inhibit the Growth and Progression of Liver Cancer in Vivo
Liver cancer is a chronic condition characterized by irregular cell growth in the liver tissues due to the alternation of cell DNA.
Most cases of primary liver cancer begin in the cells on the surface of the inner lining tissues of the liver.
Patients at the early stage of the liver cancer, due to the small size of the tumor, are asymptomatic. However, at the advanced, after colonizing the deeper layers of the liver, the malignant cells may travel a distance away to infect other nearby tissues, leading to secondary metastasis.
The liver is the largest internal organs with a function that filters out blood coming from the digestive tract before passing them to other parts of the body.
Furthermore, the liver also produces cholesterol that not only aid the gastrointestinal tract in digesting food and absorbing nutrient but also helps to build a strong cell wall, produce vitamin D and steroid hormones.
Also, at the advanced stage, patients with liver cancer may experience upper abdominal pain, abdominal swelling jaundice, and white, chalky stools accompanied by the general symptoms shared by other types of cancer.
According to the statistics provided by the American Cancer Society, in 2019, approximately 42,030 new cases (29,480 in men and 12,550 in women) will be diagnosed in the US.
Liver cancer will also cause death of about 31,780 Americans (21,600 men and 10,180 women) in 2019.
Although there are many risk factors associated with the onset of liver cancer, some researchers suggested that the rise of obesity-induced non-alcoholic liver disease may be a leading cause of liver cancer among Americans.
Dr. György Baffy wrote, "NAFLD is rapidly becoming the most common liver condition, it has been implicated in the worrisome trend of rising HCC incidence in a number of countries, which may offset successful measures in reducing the effect of virus-related liver cancer".
And, "Independently or in synergy with cirrhosis, NAFLD may provide a special oncogenic microenvironment through its pathogenic association with chronic nutrient excess and adipose tissue remodeling, characterized by pro-inflammatory adipokine profiles, lipotoxicity, altered hepatocellular bioenergetics, and insulin resistance".
In other words, you are obese with NAFLD, you are at an increased risk of liver cancer.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of liver cancer, researchers examined the effect of lycopene from tomatoes against NAFLD and hepatocellular carcinoma (HCC).
The study included tobacco carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lesions in both lungs and livers of ferrets with or without lycopene intervention.
More precisely, selected male ferrets (6 groups, n = 8-10) were treated either with NNK (50 mg/kg BW, i.p., once a month for four consecutive months) or saline with or without dietary lycopene supplementation (2.2 and 6.6 mg/kg BW/day, respectively) for 26 weeks.
Before the treatment of lycopene, NNK group showed a higher incidence of lung tumors, HCC, and steatohepatitis and elevations in bilirubin and AST levels.
Administration of lycopene supplementation at two doses not only prevented NNK-induced expressions of α7 nicotinic acetylcholine receptor in the lung associated with liver injury and cells damage but also reduced the expression of a protein associated pro-inflammation, particularly, in the level of CYP2E1 involved in the metabolism of xenobiotics in the body in the liver
Furthermore, lycopene also attenuated the NNK-induced mortality and pathological lesions in the liver of ferrets.
Based on the results, researchers said, "The present study provided strong experimental evidence that the tobacco carcinogen NNK can induce both HCC and steatohepatitis in the ferrets and can be a useful model for studying tobacco carcinogen-associated NAFLD and liver cancer".
Moreover, in the examined the natural whole foods which process anti-liver cancer potential, Dr. Zhou Y, the lead scientist wrote, "..., tomatoes,... These dietary natural products and their active components could affect the development and progression of liver cancer in various ways, such as inhibiting tumor cell growth and metastasis, protecting against liver carcinogens, immunomodulating and enhancing effects of chemotherapeutic drugs".
Taken altogether, tomatoes processed abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Natural Products for Prevention and Treatment of Liver Cancer by Zhou Y1, Li Y2, Zhou T3, Zheng J4, Li S5, Li HB. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention by György Baffy. (PMC)
Most cases of primary liver cancer begin in the cells on the surface of the inner lining tissues of the liver.
Patients at the early stage of the liver cancer, due to the small size of the tumor, are asymptomatic. However, at the advanced, after colonizing the deeper layers of the liver, the malignant cells may travel a distance away to infect other nearby tissues, leading to secondary metastasis.
The liver is the largest internal organs with a function that filters out blood coming from the digestive tract before passing them to other parts of the body.
Furthermore, the liver also produces cholesterol that not only aid the gastrointestinal tract in digesting food and absorbing nutrient but also helps to build a strong cell wall, produce vitamin D and steroid hormones.
Also, at the advanced stage, patients with liver cancer may experience upper abdominal pain, abdominal swelling jaundice, and white, chalky stools accompanied by the general symptoms shared by other types of cancer.
According to the statistics provided by the American Cancer Society, in 2019, approximately 42,030 new cases (29,480 in men and 12,550 in women) will be diagnosed in the US.
Liver cancer will also cause death of about 31,780 Americans (21,600 men and 10,180 women) in 2019.
Although there are many risk factors associated with the onset of liver cancer, some researchers suggested that the rise of obesity-induced non-alcoholic liver disease may be a leading cause of liver cancer among Americans.
Dr. György Baffy wrote, "NAFLD is rapidly becoming the most common liver condition, it has been implicated in the worrisome trend of rising HCC incidence in a number of countries, which may offset successful measures in reducing the effect of virus-related liver cancer".
And, "Independently or in synergy with cirrhosis, NAFLD may provide a special oncogenic microenvironment through its pathogenic association with chronic nutrient excess and adipose tissue remodeling, characterized by pro-inflammatory adipokine profiles, lipotoxicity, altered hepatocellular bioenergetics, and insulin resistance".
In other words, you are obese with NAFLD, you are at an increased risk of liver cancer.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of liver cancer, researchers examined the effect of lycopene from tomatoes against NAFLD and hepatocellular carcinoma (HCC).
The study included tobacco carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lesions in both lungs and livers of ferrets with or without lycopene intervention.
More precisely, selected male ferrets (6 groups, n = 8-10) were treated either with NNK (50 mg/kg BW, i.p., once a month for four consecutive months) or saline with or without dietary lycopene supplementation (2.2 and 6.6 mg/kg BW/day, respectively) for 26 weeks.
Before the treatment of lycopene, NNK group showed a higher incidence of lung tumors, HCC, and steatohepatitis and elevations in bilirubin and AST levels.
Administration of lycopene supplementation at two doses not only prevented NNK-induced expressions of α7 nicotinic acetylcholine receptor in the lung associated with liver injury and cells damage but also reduced the expression of a protein associated pro-inflammation, particularly, in the level of CYP2E1 involved in the metabolism of xenobiotics in the body in the liver
Furthermore, lycopene also attenuated the NNK-induced mortality and pathological lesions in the liver of ferrets.
Based on the results, researchers said, "The present study provided strong experimental evidence that the tobacco carcinogen NNK can induce both HCC and steatohepatitis in the ferrets and can be a useful model for studying tobacco carcinogen-associated NAFLD and liver cancer".
Moreover, in the examined the natural whole foods which process anti-liver cancer potential, Dr. Zhou Y, the lead scientist wrote, "..., tomatoes,... These dietary natural products and their active components could affect the development and progression of liver cancer in various ways, such as inhibiting tumor cell growth and metastasis, protecting against liver carcinogens, immunomodulating and enhancing effects of chemotherapeutic drugs".
Taken altogether, tomatoes processed abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Natural Products for Prevention and Treatment of Liver Cancer by Zhou Y1, Li Y2, Zhou T3, Zheng J4, Li S5, Li HB. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention by György Baffy. (PMC)
Tuesday, January 14, 2020
Dietary Patterns in the Risk of Metabolic Syndrome
A dietary pattern is the measurement of the quantity, variety, or combination of different foods and beverages in a diet as well as the frequency of the foods are habitually consumed.
Most common dietary patterns are
* The traditional diet, Wikipedia wrote, "Traditional foods are foods and dishes that are passed through generations or which have been consumed many generations. Traditional foods and dishes are traditional in nature, and may have a historic precedent in a national dish, regional cuisine or local cuisine".
* The Western diet is a standard American diet (SAD) associated with high intakes of red meat, processed meat, pre-packaged and refined foods, fried foods, high-fat dairy products, high salt, and sugar.foods.
Metabolic syndrome is a cluster of conditions associated with the increased risk of cardiovascular disease and diabetes.
The health problems found in the group include too much fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.
In other words, if you have 3 of the conditions in the group, your risk of CVD and diabetes are increased substantially compared to those who have less.
According to the statistics, approximately 30% of people in the US are living with metabolic syndrome.
Believe it or not, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988–1994 to 2007–2012, increasing from 25.3% to 34.2%.
Besides the aforementioned conditions, risks of metabolic syndrome may include age, family history, physical, inactivity, and women with polycystic ovary syndrome, epidemiologically.
As of today, the treatment of metabolic syndrome commonly is prescribed medications to reduce blood pressure, cholesterol, and/or blood sugar with an aim to reduce the risk of developing further health complications and improve quality of life.
On finding a potent ingredient for the treatment of metabolic syndrome, researchers investigated the association between major dietary patterns, including several eating habits.
The cross-sectional study included a total of 425 subjects 35 to 55 y of age, using a food-frequency questionnaire in 5 dietary patterns.
Five major dietary patterns were examined by the Isfahan University of Medical Sciences, including
* A western pattern (high in sweets, butter, soda, mayonnaise, sugar, cookies, the tail of a lamb, hydrogenated fat, and eggs),
* A prudent pattern (high in fish, peas, honey, nuts, juice, dry fruits, vegetable oil, liver and organic meat, and coconuts and low in hydrogenated fat and non-leafy vegetables),
* A vegetarian pattern (high in potatoes, legumes, fruits rich in vitamin C, rice, green leafy vegetables, and fruits rich in vitamin A),
* A high-fat dairy pattern (high in high-fat yogurt and high-fat milk and low in low-fat yogurt, peas, and bread), and
* A chicken and plant pattern (high in chicken, fruits rich in vitamin A, green leafy vegetables, and mayonnaise and low in the beef, liver, and organic meat).
Based on the tested differentiation and adjusting to other confounders,
* The western pattern has a strong and negative impact on increasing triacylglycerol and blood pressure.
* The prudent pattern was positively associated a low high-density lipoprotein cholesterol levels compared to other dietary patterns.
* However, the vegetarian dietary pattern was inversely associated with a risk of an abnormal fasting blood glucose level.
Collectively, all dietary patterns are associated with positive or negative in increasing or decreasing the risk of metabolic syndrome.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Relationship between major dietary patterns and metabolic syndrome among individuals with impaired glucose tolerance by Amini M1, Esmaillzadeh A, Shafaeizadeh S, Behrooz J, Zare M. (PubMed)
Most common dietary patterns are
* The traditional diet, Wikipedia wrote, "Traditional foods are foods and dishes that are passed through generations or which have been consumed many generations. Traditional foods and dishes are traditional in nature, and may have a historic precedent in a national dish, regional cuisine or local cuisine".
* The Western diet is a standard American diet (SAD) associated with high intakes of red meat, processed meat, pre-packaged and refined foods, fried foods, high-fat dairy products, high salt, and sugar.foods.
Metabolic syndrome is a cluster of conditions associated with the increased risk of cardiovascular disease and diabetes.
The health problems found in the group include too much fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.
In other words, if you have 3 of the conditions in the group, your risk of CVD and diabetes are increased substantially compared to those who have less.
According to the statistics, approximately 30% of people in the US are living with metabolic syndrome.
Believe it or not, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988–1994 to 2007–2012, increasing from 25.3% to 34.2%.
Besides the aforementioned conditions, risks of metabolic syndrome may include age, family history, physical, inactivity, and women with polycystic ovary syndrome, epidemiologically.
As of today, the treatment of metabolic syndrome commonly is prescribed medications to reduce blood pressure, cholesterol, and/or blood sugar with an aim to reduce the risk of developing further health complications and improve quality of life.
On finding a potent ingredient for the treatment of metabolic syndrome, researchers investigated the association between major dietary patterns, including several eating habits.
The cross-sectional study included a total of 425 subjects 35 to 55 y of age, using a food-frequency questionnaire in 5 dietary patterns.
Five major dietary patterns were examined by the Isfahan University of Medical Sciences, including
* A western pattern (high in sweets, butter, soda, mayonnaise, sugar, cookies, the tail of a lamb, hydrogenated fat, and eggs),
* A prudent pattern (high in fish, peas, honey, nuts, juice, dry fruits, vegetable oil, liver and organic meat, and coconuts and low in hydrogenated fat and non-leafy vegetables),
* A vegetarian pattern (high in potatoes, legumes, fruits rich in vitamin C, rice, green leafy vegetables, and fruits rich in vitamin A),
* A high-fat dairy pattern (high in high-fat yogurt and high-fat milk and low in low-fat yogurt, peas, and bread), and
* A chicken and plant pattern (high in chicken, fruits rich in vitamin A, green leafy vegetables, and mayonnaise and low in the beef, liver, and organic meat).
Based on the tested differentiation and adjusting to other confounders,
* The western pattern has a strong and negative impact on increasing triacylglycerol and blood pressure.
* The prudent pattern was positively associated a low high-density lipoprotein cholesterol levels compared to other dietary patterns.
* However, the vegetarian dietary pattern was inversely associated with a risk of an abnormal fasting blood glucose level.
Collectively, all dietary patterns are associated with positive or negative in increasing or decreasing the risk of metabolic syndrome.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Relationship between major dietary patterns and metabolic syndrome among individuals with impaired glucose tolerance by Amini M1, Esmaillzadeh A, Shafaeizadeh S, Behrooz J, Zare M. (PubMed)
Bilberry Protects Your Vision Against Eye Strain (Asthenopia), According to Studies
On seeking natural therapy with no side effects, scientists may have a whole fruit for the prevention and treatment of asthenopia (eye strain), according to studies.
Asthenopia is a condition characterized by nonspecific symptoms such as fatigue, pain in or around the eyes, blurred vision, headache, and occasional double vision.
Symptoms occur mostly in the people who have spent a long time in the visual task focusing, such as prolonged reading on the screen or newspaper.
Some researchers suggested by giving the eye some rest such as looking on a distant object at least once an hour can be helpful in alleviating the problem.
Mechanically, eye muscle imbalance or uncorrected vision can also cause asthenopia.
Symptoms of asthenopia include sore or irritated eyes dry or watery eyes, blurred or double vision and increased sensitivity to light.
Some people may also experience symptoms of trouble focusing and pain in the neck, shoulder, and neck.
If you experience some of the above symptoms, you may have asthenopia, please make sure you check with your doctor for preventive measures.
Some researchers suggested that asthenopia may also be a symptom in people with a chronic headache.
Dr. Vincent AJ, the lead scientist in the investigation of a chronic headache asthenopia wrote, "Sensitivity to light in the absence of a headache was reported by 27.8% of controls and 44.7% of headache sufferers (p less than 0.05)" and "The latter figure increased to 71.3% when a headache was actually present (p less than 0.001)".
These results indicated a strong correlation between a chronic headache and asthenopia.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers with an aim of finding a natural ingredient for the treatment of asthenopia examined the effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans.
A double-blind, randomized, parallel-group and the placebo-controlled trial was conducted by the Human Life Science R&D Center,
* In the Active group, eleven subjects were given a supplement containing omega-3 fatty acid-rich fish oil (docosahexaenoic acid 783 mg/day, eicosapentaenoic acid 162 mg/day), bilberry extract (anthocyanidin 59 mg/day), and lutein (17.5 mg/day) in soft gel capsule form, every day for 4 weeks.
* In the Placebo group, nine subjects were received placebo capsules.
According to the questionnaires taking before and after the experiment, researchers found that
* Asthenopia symptoms such as "stiff shoulder, low back pain", "frustration", "dry-eye", and "stuffy head" were improved in the Active group compared to the placebo.
* Subjected received the supplement also demonstrated a significant improvement od mental symptoms such as fatigue after 4 weeks.
No side effects were reported in the active group at the 2 and 4 weeks of supplemental injection, according to the return questionnaires.
The results strongly supported the use of dietary supplementation with the combination of omega-3 fatty acid-rich fish oil, bilberry extract, and lutein for the treatment of asthenopia.
Taken altogether, bilberry processed abundantly bioactive compounds may be considered a natural remedy for the treatment of dry eye with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans by Kawabata F1, Tsuji T. (PubMed)
(2) A controlled study of visual symptoms and eye strain factors in chronic headache by Vincent AJ, Spierings EL, Messinger HB. (PubMed)
Asthenopia is a condition characterized by nonspecific symptoms such as fatigue, pain in or around the eyes, blurred vision, headache, and occasional double vision.
Symptoms occur mostly in the people who have spent a long time in the visual task focusing, such as prolonged reading on the screen or newspaper.
Some researchers suggested by giving the eye some rest such as looking on a distant object at least once an hour can be helpful in alleviating the problem.
Mechanically, eye muscle imbalance or uncorrected vision can also cause asthenopia.
Symptoms of asthenopia include sore or irritated eyes dry or watery eyes, blurred or double vision and increased sensitivity to light.
Some people may also experience symptoms of trouble focusing and pain in the neck, shoulder, and neck.
If you experience some of the above symptoms, you may have asthenopia, please make sure you check with your doctor for preventive measures.
Some researchers suggested that asthenopia may also be a symptom in people with a chronic headache.
Dr. Vincent AJ, the lead scientist in the investigation of a chronic headache asthenopia wrote, "Sensitivity to light in the absence of a headache was reported by 27.8% of controls and 44.7% of headache sufferers (p less than 0.05)" and "The latter figure increased to 71.3% when a headache was actually present (p less than 0.001)".
These results indicated a strong correlation between a chronic headache and asthenopia.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers with an aim of finding a natural ingredient for the treatment of asthenopia examined the effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans.
A double-blind, randomized, parallel-group and the placebo-controlled trial was conducted by the Human Life Science R&D Center,
* In the Active group, eleven subjects were given a supplement containing omega-3 fatty acid-rich fish oil (docosahexaenoic acid 783 mg/day, eicosapentaenoic acid 162 mg/day), bilberry extract (anthocyanidin 59 mg/day), and lutein (17.5 mg/day) in soft gel capsule form, every day for 4 weeks.
* In the Placebo group, nine subjects were received placebo capsules.
According to the questionnaires taking before and after the experiment, researchers found that
* Asthenopia symptoms such as "stiff shoulder, low back pain", "frustration", "dry-eye", and "stuffy head" were improved in the Active group compared to the placebo.
* Subjected received the supplement also demonstrated a significant improvement od mental symptoms such as fatigue after 4 weeks.
No side effects were reported in the active group at the 2 and 4 weeks of supplemental injection, according to the return questionnaires.
The results strongly supported the use of dietary supplementation with the combination of omega-3 fatty acid-rich fish oil, bilberry extract, and lutein for the treatment of asthenopia.
Taken altogether, bilberry processed abundantly bioactive compounds may be considered a natural remedy for the treatment of dry eye with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of dietary supplementation with a combination of fish oil, bilberry extract, and lutein on subjective symptoms of asthenopia in humans by Kawabata F1, Tsuji T. (PubMed)
(2) A controlled study of visual symptoms and eye strain factors in chronic headache by Vincent AJ, Spierings EL, Messinger HB. (PubMed)
Herbal Ashwagandha Kills Off Kidney Cancer Cells in Vitro
Cancer, a class of diseases refers to a group of cells that grow and multiply disorderly and uncontrollably in a specific tissue of an organ.
Over time, after successfully penetrating to the deeper layers of the organs, most cancer can travel a distance away to damage other healthy tissues via lymph or blood, leading to secondary metastasis.
The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine and formed part of the detoxified organs to filter out blood by removing wastes and extra water to make urine.
Kidney cancer is a medical condition associated with cell growth irregularly that starts in the cells on the surface of the inner lining of the kidney tissue, before spreading to the deeper layers to form a tumor through unlimited cell cycle division.
According to the statistics provided by the American Cancer Society, kidney cancer is among the 10 most common cancers in both men and women in the US. In 2019, approximately, 73,820 new cases of kidney cancer will be diagnosed including 44,120 in men and 29,700 in women. The disease also causes the death of 14,770 Americans, including 9,820 men and 4,950 women in the same year.
The causes of kidney cancer are unknown. However, epidemiologically, the increase in age, gender, smoking, obesity, family diabetes, long-term exposure to chemical toxins, and use of diuretic and nondiuretic anti-hypertensive medication are some prevalent factors found in patients with kidney cancer.
Some researchers suggested the increased incidence of kidney cancer in the US may correlate to obesity caused by the promotion of a high-fat diet over the past decades.
Dr. Wilson KM, the lead scientist in the joint study led by the Chan School of Public Health wrote, "Obesity has been largely measured as body mass index (BMI). Studies which evaluated other measures of obesity including waist circumference (WC), waist-to-hip ratio (WHR) as well as an increase in weight have reported similar positive associations with RCC".
And " Although the mechanisms by which obesity influences renal carcinogenesis have been under-explored, insulin resistance and certain growth factors including insulin-like growth factor (IGF-1), sex steroid hormones, and biochemical markers such as adiponectin may be involved".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound which process renal protective activity, researchers examined the effects of Withaferin A, a major chemical constituent of Withania somnifera, in the renal cancer cell line.
According to tested analysis, withaferin A application resulted in apoptotic cell death in several types of human renal cancer cells in a dose-dependent manner.
Furthermore, withaferin A inhibited the Caki cells by inducing signature endoplasmic reticulum (ER) stress markers, leading to the accumulation of unfolded proteins associated with cancer cell death.
Moreover, CAAT/enhancer-binding protein-homologous protein (CHOP) associated with pro-apoptotic function in the integrated stress response was elevated by the injection of withaferin A.
Interestingly, withaferin A-induced ER stress to cause cytotoxicity against renal cancer cells by increasing levels of reactive oxygen species (ROS).
Based on the findings, researchers said, "the present study provides strong evidence supporting an important role of the ER stress response in mediating withaferin A-induced apoptosis".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of renal cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells by Choi MJ1, Park EJ, Min KJ, Park JW, Kwon TK. (PubMed)
(2) Obesity and Kidney Cancer by Wilson KM1,2, Cho E. (PubMed)
Over time, after successfully penetrating to the deeper layers of the organs, most cancer can travel a distance away to damage other healthy tissues via lymph or blood, leading to secondary metastasis.
The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine and formed part of the detoxified organs to filter out blood by removing wastes and extra water to make urine.
Kidney cancer is a medical condition associated with cell growth irregularly that starts in the cells on the surface of the inner lining of the kidney tissue, before spreading to the deeper layers to form a tumor through unlimited cell cycle division.
According to the statistics provided by the American Cancer Society, kidney cancer is among the 10 most common cancers in both men and women in the US. In 2019, approximately, 73,820 new cases of kidney cancer will be diagnosed including 44,120 in men and 29,700 in women. The disease also causes the death of 14,770 Americans, including 9,820 men and 4,950 women in the same year.
The causes of kidney cancer are unknown. However, epidemiologically, the increase in age, gender, smoking, obesity, family diabetes, long-term exposure to chemical toxins, and use of diuretic and nondiuretic anti-hypertensive medication are some prevalent factors found in patients with kidney cancer.
Some researchers suggested the increased incidence of kidney cancer in the US may correlate to obesity caused by the promotion of a high-fat diet over the past decades.
Dr. Wilson KM, the lead scientist in the joint study led by the Chan School of Public Health wrote, "Obesity has been largely measured as body mass index (BMI). Studies which evaluated other measures of obesity including waist circumference (WC), waist-to-hip ratio (WHR) as well as an increase in weight have reported similar positive associations with RCC".
And " Although the mechanisms by which obesity influences renal carcinogenesis have been under-explored, insulin resistance and certain growth factors including insulin-like growth factor (IGF-1), sex steroid hormones, and biochemical markers such as adiponectin may be involved".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound which process renal protective activity, researchers examined the effects of Withaferin A, a major chemical constituent of Withania somnifera, in the renal cancer cell line.
According to tested analysis, withaferin A application resulted in apoptotic cell death in several types of human renal cancer cells in a dose-dependent manner.
Furthermore, withaferin A inhibited the Caki cells by inducing signature endoplasmic reticulum (ER) stress markers, leading to the accumulation of unfolded proteins associated with cancer cell death.
Moreover, CAAT/enhancer-binding protein-homologous protein (CHOP) associated with pro-apoptotic function in the integrated stress response was elevated by the injection of withaferin A.
Interestingly, withaferin A-induced ER stress to cause cytotoxicity against renal cancer cells by increasing levels of reactive oxygen species (ROS).
Based on the findings, researchers said, "the present study provides strong evidence supporting an important role of the ER stress response in mediating withaferin A-induced apoptosis".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of renal cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells by Choi MJ1, Park EJ, Min KJ, Park JW, Kwon TK. (PubMed)
(2) Obesity and Kidney Cancer by Wilson KM1,2, Cho E. (PubMed)
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