Vasoprotection is a term characterized by protecting your blood vessel against the onset of heart disease and stroke.
Blood vessel formed part of the vascular or circulation system that transports the oxygen and nutrients blood to the body tissue and removes unnecessary waste products.
The circulation system also plays an essential role in transporting hormones to the body's needs.
The most common cause of abnormal vascular system is the accumulation of plaque on the arterial wall due to the deposit blood cholesterol and other substances such as calcium and cadmium, leading to hardening and narrowing the arteries over time.
Atherosclerosis is a disease associated with plaque that builds up inside the arteries, a major cause of heart disease and stroke.
Vascular disease can be serious. Blood clots can clog vessels and block blood flow to the heart or brain.
Some researchers suggested that widespread vascular disease in the Western world probably is associated with the promotion of the Western diet over the past few decades.
Dr. Rachel P Ogilvie, the lead scientist, in the examination of the Western diet in the risk of vascular disease, wrote, "Peripheral arterial disease (PAD) is a costly source of morbidity and mortality among older persons in the United States. Dietary intake plays a role in the development of atherosclerotic cardiovascular disease".
And, "...greater meat consumption was associated with a higher risk".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researcher on the finding a natural therapeutic with vasoprotective activity investigated investigate the effects of artichoke on iNOS expression in human coronary artery smooth muscle cells (HCASMC).
The study included HCASMC incubated with a cytokine mixture to induce nitric oxide synthases (iNOS) mRNA expression.
Application of an artichoke leaf extract (1-100 µg/mL, 6 h or 24 h) inhibited the levels of iNOS in concentration- and time-dependent manner.
By inhibiting the expression of iNOS, the artichoke leaf extract also reduced pro-inflammatory cytokine activation by iNOS.
Where nitric oxide synthases are a family of enzymes involved in the production of nitric oxide from L-arginine.
And, Nitric oxide (NO) induces an anti-inflammatory effect under normal physiological conditions. However, under abnormal conditions, NO is considered a pro-inflammatory mediator-induced inflammation.
Additional analysis of the extract against NO in the induction of vascular inflammation and intimal hyperplasia, researchers found that the vasoprotection of the extract was attributed to the four well-known artichoke compounds including cynarin, cyanidin, luteolin, and cynaroside.
In other words, artichoke contains both endothelial nitric-oxide synthase (eNOS-exhibition and iNOS-inhibition compounds.
Where eNOS- is a critical regulator of cardiovascular homeostasis.
Furthermore, in order to reveal more information about nitric oxide (NO) produced by endothelial nitric-oxide synthase (eNOS) represents an antithrombotic and anti-atherosclerotic principle in the vasculature, researchers examined the effect of artichoke extract incubated with human umbilical vein endothelial cells (HUVECs),
According to the luciferase reporter gene assay, artichoke leaf extract (ALE) increased the activity of the human eNOS promoter in EA.hy 926 cells, a cell line derived from human umbilical vein endothelial cells (HUVECs).
By comparing the application of different doses used in the experiment, researchers found organic subfraction from ALE was more potent in this respect than the crude extract, whereas an aqueous subfraction of ALE was without effect in EA.hy 926 cells.
Furthermore, injection of ALE and the organic subfraction increased eNOS mRNA expression and eNOS protein expression both in EA.hy 926 cells and HUVECs.
Interestingly, the flavonoids luteolin and cynaroside increased eNOS promoter activity and eNOS mRNA expression, compared to no effect of caffeoylquinic acids cynarin and chlorogenic acid.
In other words, artichoke increased eNOS gene transcription for the protection of cardiovascular profile was also attributed additionally by the lipid-lowering and antioxidant properties.
Taken altogether, artichoke may be considered a functional remedy for the protection of blood vessels against the risk of cardiovascular disease with no side effects, pending to the validation of larger sample size and multicenter human study.
Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells by Xia N1, Pautz A1, Wollscheid U1, Reifenberg G1, Förstermann U1, Li H. (PubMed)
(2) Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells by Li H1, Xia N, Brausch I, Yao Y, Förstermann U. (PubMed)
(3) Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study by Rachel P Ogilvie, Pamela L Lutsey, Gerardo Heiss Aaron R Folsom, and Lyn M Steffen (Oxford)
Friday, February 14, 2020
Bromelain Promotes Anti Inflammatory Activity Against Allergic Asthma
Allergic asthma is the most common form of asthma, triggered by inhaling allergens such as dust mites, pet dander, pollen or mold.
The condition, in most cases, is involved in the overreaction of the immune system against the unharmful allergens, leading to tightening the muscle of the airway.
Most common allergens facilitate the onset of allergic asthma include, including pollen from trees, grasses, and weeds, mold spores, and fragments, animal dander.
Other conditions such as smoking, a fireplace, candles, incense, or fireworks, air pollution, chemical fumes are also found to induce allergic asthma in the US.
Most common symptoms of allergic asthma are coughing, wheezing, shortness of breath and tight chest.
Severe allergic asthma can also cause complications such as hives, mouth or facial swelling, difficulty swallowing.
According to the Allergy and Asthma Network, 8.0 percent (19.1 million) of adults over age 18 in the U.S. have respiratory allergies, 8.4 percent (6.1 million) of children in the U.S. have respiratory allergies.
Conventionally, medications used for treating allergic asthma are focusing to reduce symptoms and improve quality of life.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential ingredient for the treatment of asthma, researchers examined the asthmatic protective of bromelain in C57BL/6J mice sensitized with OVA/alum and challenged with 7 days OVA aerosol.
Selected mice included in the study were received sBr 6 mg/kg/0.5 ml or PBS vehicle throughout sensitization.
According to the tested assays, sBr treatment throughout OVA-alum sensitization significantly reduced the development of allergic airway disease (AAD) by balancing the levels of BAL eosinophils and lymphocytes.
Furthermore, sBr decreased the levels of OVA-specific IgE and OVA TET(+) cells by inhibiting the elevated levels of CD11c(+) dendritic cell-associated with inflammation and CD44, a marker of inflammatory disease.
Based on the findings, researchers wrote, "These results provide additional insight into sBr's anti-inflammatory and antiallergic properties and rationale for translation into the clinical arena".
In order to reveal more information about bromelain anti-asthmatic symptoms, researchers investigated the ability of bromelain in reducing the inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
Selected mice used in the study received either received phosphate-buffered saline (PBS) only or bromelain in PBS as the intervention group.
According to the results at the end of the experiment, bromelain treatment of AAD mice (bromelain group) showed a significant anti-inflammatory activity observed by reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates via lung pathology, compared to the control.
Bromelain also significantly reduced BAL CD4+ and CD8+ T cells, an indication of normal immune activity without affecting cell numbers in the spleen or hilar lymph node.
In other words, bromelain inhibited allergic airway inflammation associated with the onset of asthma by inhibiting the production of pro-inflammatory cytokines through modulating the immune function.
Dr. Secor ER Jr, the leads scientist wrote, "The results suggest that bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of allergic asthma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells by Secor ER Jr1, Szczepanek SM2, Castater CA3, Adami AJ2, Matson AP4, Rafti ET4, Guernsey L2, Natarajan P2, McNamara JT5, Schramm CM4, Thrall RS2, Silbart LK. (PubMed)
The condition, in most cases, is involved in the overreaction of the immune system against the unharmful allergens, leading to tightening the muscle of the airway.
Most common allergens facilitate the onset of allergic asthma include, including pollen from trees, grasses, and weeds, mold spores, and fragments, animal dander.
Other conditions such as smoking, a fireplace, candles, incense, or fireworks, air pollution, chemical fumes are also found to induce allergic asthma in the US.
Most common symptoms of allergic asthma are coughing, wheezing, shortness of breath and tight chest.
Severe allergic asthma can also cause complications such as hives, mouth or facial swelling, difficulty swallowing.
According to the Allergy and Asthma Network, 8.0 percent (19.1 million) of adults over age 18 in the U.S. have respiratory allergies, 8.4 percent (6.1 million) of children in the U.S. have respiratory allergies.
Conventionally, medications used for treating allergic asthma are focusing to reduce symptoms and improve quality of life.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential ingredient for the treatment of asthma, researchers examined the asthmatic protective of bromelain in C57BL/6J mice sensitized with OVA/alum and challenged with 7 days OVA aerosol.
Selected mice included in the study were received sBr 6 mg/kg/0.5 ml or PBS vehicle throughout sensitization.
According to the tested assays, sBr treatment throughout OVA-alum sensitization significantly reduced the development of allergic airway disease (AAD) by balancing the levels of BAL eosinophils and lymphocytes.
Furthermore, sBr decreased the levels of OVA-specific IgE and OVA TET(+) cells by inhibiting the elevated levels of CD11c(+) dendritic cell-associated with inflammation and CD44, a marker of inflammatory disease.
Based on the findings, researchers wrote, "These results provide additional insight into sBr's anti-inflammatory and antiallergic properties and rationale for translation into the clinical arena".
In order to reveal more information about bromelain anti-asthmatic symptoms, researchers investigated the ability of bromelain in reducing the inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).
Selected mice used in the study received either received phosphate-buffered saline (PBS) only or bromelain in PBS as the intervention group.
According to the results at the end of the experiment, bromelain treatment of AAD mice (bromelain group) showed a significant anti-inflammatory activity observed by reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates via lung pathology, compared to the control.
Bromelain also significantly reduced BAL CD4+ and CD8+ T cells, an indication of normal immune activity without affecting cell numbers in the spleen or hilar lymph node.
In other words, bromelain inhibited allergic airway inflammation associated with the onset of asthma by inhibiting the production of pro-inflammatory cytokines through modulating the immune function.
Dr. Secor ER Jr, the leads scientist wrote, "The results suggest that bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of allergic asthma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells by Secor ER Jr1, Szczepanek SM2, Castater CA3, Adami AJ2, Matson AP4, Rafti ET4, Guernsey L2, Natarajan P2, McNamara JT5, Schramm CM4, Thrall RS2, Silbart LK. (PubMed)
Garlic, The Whole Food Medicine for Reduced Risk and Treatment of Gastric Cancer
Scientists from various respectable institutions suggested that out of many herbs, garlic may be one of the most powerful whole food medicine in reduced risk of gastric cancer due to the effects of phytochemicals.
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Stomach or Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
Diallyl disulfide(DADS), an antioxidant found in garlic inhibited the proliferation of several tumor cells by interfering in cell cycle arrest. Administrated garlic induced the reduction of 23% of the live gastric adenocarcinoma cell line(AGS) in the G(2)-M phase, after 400 µM DADS treatment for 48 hours.
Dr. Wang X, the lead author in the animal study said,"... Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo, may be partly due to its antioxidant and immunomodulatory effects"
In fact, the effectiveness of garlic in reduced risk and treatment of gastric cancer probably is due to its antioxidants, such as Diallyl disulfide(DADS) and extract in inhibition of cancer cells through the influence of cell cycle division and negation of proinflammatory pathways.
Some researchers suggested using garlic as chemopreventive therapy, as the experiment showed that garlic scavenges free radicals, and inhibits cell proliferation of tumor growth.
Therefore, people who add an additional portion of garlic into their diet may see the risk of gastric cancer development reduced substantially.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line by Lee JE1, Lee RA, Kim KH, Lee JH.(PubMed)
(2) Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC). by Yan JY1, Tian FM, Hu WN, Zhang JH, Cai HF, Li N.(PubMed)
(3) Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. by Wang X1, Jiao F, Wang QW, Wang J, Yang K, Hu RR, Liu HC, Wang HY, Wang YS(PubMed).
(4) Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment by Jiang XY1, Zhu XS1, Xu HY1, Zhao ZX1,2,3, Li SY1, Li SZ3, Cai JH3, Cao JM3(PubMed)
(5) The Mechanism in Gastric Cancer Chemoprevention by Allicin by Luo R, Fang D, Hang H, Tang Z1.(PubMed)
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Stomach or Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
Diallyl disulfide(DADS), an antioxidant found in garlic inhibited the proliferation of several tumor cells by interfering in cell cycle arrest. Administrated garlic induced the reduction of 23% of the live gastric adenocarcinoma cell line(AGS) in the G(2)-M phase, after 400 µM DADS treatment for 48 hours.
Dr. Wang X, the lead author in the animal study said,"... Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo, may be partly due to its antioxidant and immunomodulatory effects"
In fact, the effectiveness of garlic in reduced risk and treatment of gastric cancer probably is due to its antioxidants, such as Diallyl disulfide(DADS) and extract in inhibition of cancer cells through the influence of cell cycle division and negation of proinflammatory pathways.
Some researchers suggested using garlic as chemopreventive therapy, as the experiment showed that garlic scavenges free radicals, and inhibits cell proliferation of tumor growth.
Therefore, people who add an additional portion of garlic into their diet may see the risk of gastric cancer development reduced substantially.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Induction of apoptosis with diallyl disulfide in AGS gastric cancer cell line by Lee JE1, Lee RA, Kim KH, Lee JH.(PubMed)
(2) Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC). by Yan JY1, Tian FM, Hu WN, Zhang JH, Cai HF, Li N.(PubMed)
(3) Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. by Wang X1, Jiao F, Wang QW, Wang J, Yang K, Hu RR, Liu HC, Wang HY, Wang YS(PubMed).
(4) Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment by Jiang XY1, Zhu XS1, Xu HY1, Zhao ZX1,2,3, Li SY1, Li SZ3, Cai JH3, Cao JM3(PubMed)
(5) The Mechanism in Gastric Cancer Chemoprevention by Allicin by Luo R, Fang D, Hang H, Tang Z1.(PubMed)
Thursday, February 13, 2020
Cranberry Inhibits the Risk and Symptoms of Bladder Cystitis
The bladder formed part of the secretary system is a muscular sac in the pelvis, just above and behind the pubic bone, playing a critical role for collect and secret urine made by the kidneys.
Cystitis is a medical condition associated with inflammation of the bladder, leading to the symptoms of bladder irritation and swelling. Women are prone to the condition compared to men.
Bladder cystitis or bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic syndrome associated with pelvic pain urgency and frequency. The condition is not considered a disease due to the difficulty to rule out all differential diagnoses only from history.
The most common cause of bladder cystitis is a bacterial infection involved in the urinary tract. However, radiotherapy, long-term use of certain medicines and hygiene products have also been found to induce bladder inflammation.
The most common symptoms of cystitis are frequent urge to urinate, urge to urinate after you’ve emptied your bladder, cloudy or strong-smelling urine, pain during sexual intercourse and sensations of pressure or bladder fullness.
In serious cases, patients may also experience symptoms of fever, blood in your urine and cramping in your abdomen or back.
Conventionally, antibiotics are the first line of treatment for bladder cystitis, if the bacteria that cause the infection has been identified.
Most cases of acute cystitis are treated by nitrofurantoin monohydrate/macrocrystals, trimethoprim-sulfamethoxazole (TMP-SMX) accompanied by nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil) or acetaminophen (Tylenol) to reduce pain and inflammation.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of prostate diseases, researchers examined the effect of highly standardized cranberry capsules (containing 72 mg proanthocyanidins [PACS]) compared with that of placebo capsules on the incidence and severity of radiation cystitis.
In a total of 41 men with prostate cancer participated in a double-blinded randomized placebo-controlled study, taking one capsule a day at breakfast during treatment and for 2 weeks after treatment completion, researchers, according to the tested analysis found that
Cranberry capsules show a significantly reduced incidence of cystitis to 65% compared to placebo capsules of 90%.
The severe cystitis is only present in 30% of men in the cranberry arm and 45% of the placebo.
Overall, the incidence of pain/burning is significantly lower in the cranberry compared to the placebo.
Additionally, cranberry injection shows less pain/burning, stronger urine stream and used significantly fewer pads/liners, in men on the low hydration regimen compared to those on the high hydration regimen.
Based on the findings, researchers concluded. "Men receiving radiation therapy for prostate cancer may benefit from using cranberry capsules, particularly those on low hydration regimens or with baseline urinary symptoms".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of cystitis.in prostate cancer patients, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: a randomized double blinded, placebo controlled pilot study by Hamilton K1, Bennett NC, Purdie G, Herst PM. (PubMed)
(2) Cranberry and recurrent cystitis: more than marketing? by Micali S1, Isgro G, Bianchi G, Miceli N, Calapai G, Navarra M. (PubMed)
Cystitis is a medical condition associated with inflammation of the bladder, leading to the symptoms of bladder irritation and swelling. Women are prone to the condition compared to men.
Bladder cystitis or bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic syndrome associated with pelvic pain urgency and frequency. The condition is not considered a disease due to the difficulty to rule out all differential diagnoses only from history.
The most common cause of bladder cystitis is a bacterial infection involved in the urinary tract. However, radiotherapy, long-term use of certain medicines and hygiene products have also been found to induce bladder inflammation.
The most common symptoms of cystitis are frequent urge to urinate, urge to urinate after you’ve emptied your bladder, cloudy or strong-smelling urine, pain during sexual intercourse and sensations of pressure or bladder fullness.
In serious cases, patients may also experience symptoms of fever, blood in your urine and cramping in your abdomen or back.
Conventionally, antibiotics are the first line of treatment for bladder cystitis, if the bacteria that cause the infection has been identified.
Most cases of acute cystitis are treated by nitrofurantoin monohydrate/macrocrystals, trimethoprim-sulfamethoxazole (TMP-SMX) accompanied by nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil) or acetaminophen (Tylenol) to reduce pain and inflammation.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of prostate diseases, researchers examined the effect of highly standardized cranberry capsules (containing 72 mg proanthocyanidins [PACS]) compared with that of placebo capsules on the incidence and severity of radiation cystitis.
In a total of 41 men with prostate cancer participated in a double-blinded randomized placebo-controlled study, taking one capsule a day at breakfast during treatment and for 2 weeks after treatment completion, researchers, according to the tested analysis found that
Cranberry capsules show a significantly reduced incidence of cystitis to 65% compared to placebo capsules of 90%.
The severe cystitis is only present in 30% of men in the cranberry arm and 45% of the placebo.
Overall, the incidence of pain/burning is significantly lower in the cranberry compared to the placebo.
Additionally, cranberry injection shows less pain/burning, stronger urine stream and used significantly fewer pads/liners, in men on the low hydration regimen compared to those on the high hydration regimen.
Based on the findings, researchers concluded. "Men receiving radiation therapy for prostate cancer may benefit from using cranberry capsules, particularly those on low hydration regimens or with baseline urinary symptoms".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of cystitis.in prostate cancer patients, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: a randomized double blinded, placebo controlled pilot study by Hamilton K1, Bennett NC, Purdie G, Herst PM. (PubMed)
(2) Cranberry and recurrent cystitis: more than marketing? by Micali S1, Isgro G, Bianchi G, Miceli N, Calapai G, Navarra M. (PubMed)
Herbal Cayenne and Non Allergic Rhinitis
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.
Nonallergic rhinitisis defined as condition with symptoms resemble an allergy causes of ahiitis but without a known cause. Chronic forms of rhinitis occurred in the absence of any detectable specific IgE against relevant aeroallergens in its broadest sense can be called chronic nonallergic rhinitis(1).
ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum, showed to exhibit significant differences in changes from baseline and improvement in nasal congestion, sinus pain, sinus pressure, and headache, at 5, 10, 15, and 30 minutes, persisting at 60 minutes for nasal congestion and sinus pain in patients with Nonallergic rhinitis(2).
The intranasal capsaicin spray, also showed a significant and long-term reduction of symptoms in nonallergic noninfectious perennial rhinitis patients, and five treatments of capsaicin on a single day at least is comparable to five treatments of capsaicin in 2 weeks, in a 30 nonallergic noninfectious perennial rhinitis patients randomized into two different treatment regimens: one group received capsaicin five times on the first day at 1-h intervals(3).
The Side Effects
1. It may cause allergic reaction in young children
2. It may also cause hypertensive response if overdosed.
3. It may promote symptoms of acute anal fissure.
4. It may cause burning sensation to certain people in the first taste
5. Do not use cayenne pepper in young children
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Nonallergic rhinitis by Lieberman P1, Pattanaik D.(PubMed)
(2) A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis by Bernstein JA1, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS.(PubMed)
(3) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study by Van Rijswijk JB1, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ.(PubMed)
Nonallergic rhinitisis defined as condition with symptoms resemble an allergy causes of ahiitis but without a known cause. Chronic forms of rhinitis occurred in the absence of any detectable specific IgE against relevant aeroallergens in its broadest sense can be called chronic nonallergic rhinitis(1).
ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum, showed to exhibit significant differences in changes from baseline and improvement in nasal congestion, sinus pain, sinus pressure, and headache, at 5, 10, 15, and 30 minutes, persisting at 60 minutes for nasal congestion and sinus pain in patients with Nonallergic rhinitis(2).
The intranasal capsaicin spray, also showed a significant and long-term reduction of symptoms in nonallergic noninfectious perennial rhinitis patients, and five treatments of capsaicin on a single day at least is comparable to five treatments of capsaicin in 2 weeks, in a 30 nonallergic noninfectious perennial rhinitis patients randomized into two different treatment regimens: one group received capsaicin five times on the first day at 1-h intervals(3).
The Side Effects
1. It may cause allergic reaction in young children
2. It may also cause hypertensive response if overdosed.
3. It may promote symptoms of acute anal fissure.
4. It may cause burning sensation to certain people in the first taste
5. Do not use cayenne pepper in young children
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Nonallergic rhinitis by Lieberman P1, Pattanaik D.(PubMed)
(2) A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis by Bernstein JA1, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS.(PubMed)
(3) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study by Van Rijswijk JB1, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ.(PubMed)
Herbal Butterbur, The Anti Acute and Chronic Migraine Herbal and Functional Remedy, Scientists Say
Herbal butterbur may be considered as functional herb in protection of neurons against change in the brain and its surrounding blood vessels in initiated onset of migraine, some scientists suggested.
Migraine headache is one most common headache defined as condition of chronic neurological disorder of moderate to severe headaches, and nausea that usually develop gradually over 5–20 minutes and last for less than 60 minutes.
According to the statistic, the syndrome affects over 15% of the population in US. If you are women your risk of migraine headache is at 2 times higher in compared to men.
Sadly, 1 in 7 people in the world population will develop migraine headache at some points in their life time, And, chronic migraine affects about 2% of the world population.
Some patients during migraine attack also suffer symptoms of visual disturbances, nausea, vomiting, dizziness, extreme sensitivity to sound, light, touch and smell, and tingling or numbness in the extremities or face.
Believe or not, 10% school age children also suffer from undiagnosed migraine headache.
Conventional medicine in reduced symptoms of pain during attack such as Sumatriptan, Rizatriptan,..and Eletriptan may be effective but they may induce certain side effects, including gastrointestinal discomfort, dizziness, drowsiness,... and muscle weakness.
Please make sure that you discuss these side effect with your doctor before taking.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herb has been used in herbal medicne used as an pain reliever in digestive system, including stomach, bile ducts, and duodenum, etc.
The Chemical constituents
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
Although the herb is used as nutritional supplement in US, scientific studies suggested that it may be used as the prevention of allergic rhinitis and treatment of migraine.
In a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine, satisfied the International Headache Society criteria, researchers found that by calculating the migraine attack frequ.
ency per month as percentage change from baseline over a 4-month treatment period
* Migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), in compared to 26% of placebo group.
* The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05).
* In compared to the baseline, patients, intake of Petasites 75 mg also also expressed a significant effect in reduced migraine at 1, 2, and 3 months.
* Mild adverse effects such as gastrointestinal events, predominantly burping. were also reported.
These results sugegsted that butterbur Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine.
Furthermore, in the review to confirm the strength of evidence of effectiveness for Petasites hybridus in treating prophylaxis of migraine by searching several databases and other sources to identify randomised-controlled trials, the Headache Center Hirslanden in Zürich, Switzerland found 2 trials totalling 293 patients (60 and 233 patients).
According to the selected trials, oral administrated butterbur extract at higher dose (150 mg) expressed a greater decreased frequency of migraine attacks and a greater number of responders (improvement>50%) after treatment over 3-4 months in compared to the extract at lower dose (100 mg) and placebo.
Additional differentiation also found some evidences that higher than the recommended dose may be more effective in treating prophylaxis of migraine.
More profoundly, in the study of 60 patients received either the special Petasites hybridus extract Petadolex or placebo at a dosage of two capsules (each capsule contains 25 mg) twice daily over 12 weeks, researchers found that
* Oral injection of the capsules Petadolex reduces the frequency of migraine attacks decreased by a maximum of 60 percent in compared to the baseline.
* No adverse events were reported. Petasites was exceptionally well tolerated.
Taking altogether, herbal butterbur extract may be considered as therapeutic treatment in acute and chronic migraine headache, however, exact dose should only be prescribed by herbalist.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye FloatersContrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine by Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A.(PubMed)
(2) An extract of Petasites hybridus is effective in the prophylaxis of migraine by Grossman W, Schmidramsl H.(PubMed)
(3) Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review by Agosti R, Duke RK, Chrubasik JE, Chrubasik S.(PubMed)
Wednesday, February 12, 2020
Chaste tree berry, The Whole Herb Medicine for Treatment of Hyperprolactinemia Associated to Premenstrual Syndrome
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
Hyperprolactinemia is a condition of elevated serum of prolactin which is the hormone in regulated
breast development and lactation during puberty and pregnancy, respectively.
High levels of prolactin have been found to associate with elevated symptoms in premenstrual syndrome women. Administration of herbal Chaste tree berry may ease the symptoms and treatment of mild and serve cases of PMS.
According to the Second Military Medical University, in the induced hyperprolactinemia SD rat models by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d), injection of casticin, a flavonoid isolated from Vitex rotundifolia in treatment group, exhibited the reduction of (10, 20, and 40 mg/kg, ip, for 7 d) serum prolactin levels by 33.9%, 54.3%, and 64.7%,.compared untreated control group.
Dr. YE Q, the lead author in the study said, casticin ameliorated the stimulation of pituitary cells with 17β-Estradiol (E2), a female sex hormone in prolactin secretion.
The study also found that casticin at doses of 0.1, 1, and 10 micromol/L, significantly inhibited the prolactin release stimulated by 17β-Estradiol (E2) in a concentration-dependent manner., through regulating the DNA expression of estrogen receptors inactivated sex hormone for the secretion of porcelain.
In the review of pharmacology and clinical indications of the effectiveness of chaste tree berry in PMS women. the University of Göttingen found that
1. The herbal extract consisted of a beneficial influence in most common premenstrual symptoms, indicated by double-blind placebo-controlled studies.
2. Numerous less rigidly controlled studies indicated that AC extracts reduced premenstrual mastodynia through inhibiting levels of prolactin through suppressed the stimulation of the mammary gland in response to stressful situations and during deep sleep phases.
Dr. Wuttke W said" The search for the chemical identity of the dopaminergic compounds resulted in isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects" and "dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome".
Taking together, Chaste tree berry may be beneficial in reduced symptoms for women with PMS during the menstrual cycle, especially in hyperprolactinemia induced premenstrual breast pain and discomfort.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)
(2) Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications by Wuttke W1, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D.(PubMed)
Hyperprolactinemia is a condition of elevated serum of prolactin which is the hormone in regulated
breast development and lactation during puberty and pregnancy, respectively.
High levels of prolactin have been found to associate with elevated symptoms in premenstrual syndrome women. Administration of herbal Chaste tree berry may ease the symptoms and treatment of mild and serve cases of PMS.
According to the Second Military Medical University, in the induced hyperprolactinemia SD rat models by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d), injection of casticin, a flavonoid isolated from Vitex rotundifolia in treatment group, exhibited the reduction of (10, 20, and 40 mg/kg, ip, for 7 d) serum prolactin levels by 33.9%, 54.3%, and 64.7%,.compared untreated control group.
Dr. YE Q, the lead author in the study said, casticin ameliorated the stimulation of pituitary cells with 17β-Estradiol (E2), a female sex hormone in prolactin secretion.
The study also found that casticin at doses of 0.1, 1, and 10 micromol/L, significantly inhibited the prolactin release stimulated by 17β-Estradiol (E2) in a concentration-dependent manner., through regulating the DNA expression of estrogen receptors inactivated sex hormone for the secretion of porcelain.
In the review of pharmacology and clinical indications of the effectiveness of chaste tree berry in PMS women. the University of Göttingen found that
1. The herbal extract consisted of a beneficial influence in most common premenstrual symptoms, indicated by double-blind placebo-controlled studies.
2. Numerous less rigidly controlled studies indicated that AC extracts reduced premenstrual mastodynia through inhibiting levels of prolactin through suppressed the stimulation of the mammary gland in response to stressful situations and during deep sleep phases.
Dr. Wuttke W said" The search for the chemical identity of the dopaminergic compounds resulted in isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects" and "dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome".
Taking together, Chaste tree berry may be beneficial in reduced symptoms for women with PMS during the menstrual cycle, especially in hyperprolactinemia induced premenstrual breast pain and discomfort.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)
(2) Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications by Wuttke W1, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D.(PubMed)
Subscribe to:
Posts (Atom)