Retinal degeneration is a condition of retinopathy associated with the gradual loss of neurons near the inner surface of the retina of the eyes.
Most cases of retinopathy are caused by abnormal blood flow.
The most common forms of retinal degeneration are macular degeneration which is a condition when the small central portion of the retina, (the macula) deteriorates and retinitis pigmentosa (RP) which is a rare genetic disorder involved a breakdown and loss of cells in the retina.
Retinal degeneration disease has been found to have a strong impact on daily life, ranging from performing basic functions to personal independence and mental health and vision loss.
According to the statistics, the overall prevalence of age-related macular degeneration (AMD) is in the range of 1.38%-1.55%) and retinitis pigmentosa is 1 in 3,500 to 1 in 4,000 individuals.
Age-related macular degeneration affects more than 1.75 million individuals in the United States, and the number is increasing rapidly due to the growth of an aging population. The number of persons having AMD will increase by 50% to 2.95 million in 2020.
Symptoms of retinal degeneration may include blurred central vision or a blind spot in the center of the visual field.
In severe cases, loss of vision may be possible, particularly in people over the age of 60.
Dr. Rita Ehrlich, the lead scientist said, "Age-related macular degeneration (AMD) is an ocular disease that causes damage to the retinal macula, mostly in the elderly. Normal aging processes can lead to structural and blood flow changes that can predispose patients to AMD".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers in the concern about retinal degenerative diseases induced vision loss and retinal cell death examined the protective effects of the complex lutein formula (CLF) by combining several natural compounds: Calendula officinalis, Lycium barbarum, Vaccinium myrtillus, Cassia obtusifolia, and Rhodiola Rosea.
The formula showed significant protection of retinal functions in an animal model for light-induced retinal degeneration.
Before applying the formula, retinal function in animals exposed to light for 7 days decreased significantly.
However, CLF injection improved the superiority of the retinal function despite light exposure.
Furthermore, CLF restored a greater portion of the outer nuclear layer (ONL) (i.e. the nuclei of photoreceptors) in these animals compared to that of animals that had not received the formula after 7 days of light exposure.
The findings strongly suggested CLF including bilberry exerted a retinal protect against the gradual loss of vision caused by degeneration.
Dr. the lead scientist after taking other factors into account wrote in the final report, "our dietary CLF supplement attenuated retinal function loss resulting from long-term light exposure".
Long term light exposure on animal models has been associated with retinal degeneration, as it damages the retina (phototoxicity) and decreases photoreceptor which has strong implications for age-related macular degeneration.
Taken altogether, bilberry used alone or combined with other herbal remedies may be considered functional remedies for the prevention of retinal degeneration, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of a complex lutein formula in an animal model for light-induced retinal degeneration by Cheng YP1, Ke CY2, Kuo CC1, Lee YJ. (PubMed)
Saturday, February 22, 2020
Herbal Ashwagandha Protects the Neurons Against the Risk of Neuroblastoma
A neuron is a nerve cell that forms a building block of the nervous system.
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.
Cancer most commonly affects children age 5 or younger compared to less often in older children.
According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.
And 90% of children affected by neuroblastoma are children younger than 5.
Sadly, the the-5-year survival rate of cancer is less than 50%.
The most common symptoms are totally depending on the area that has been effected* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched and changes in bowel habits, such as diarrhea or constipation.
* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain and changes to the eyes, including drooping eyelids and unequal pupil size
Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the protection of neurons, researchers examined the effects of ashwagandha root extract consumption on human neuroblastoma (IMR32).
Human neuroblastoma (IMR32) cells, pretreated with Ashwagandha-reagents for 24 h, were exposed to H2O2 (300 μM) for 2 h, before incubating in control or test medium supplemented with either the alcoholic (i-Extract) or water (WEX) extracts or their active components (withanone or withaferin A), showed a significant effect on H2O2 by 40%.
Furthermore, i-Extract, withanone or WEX also resulted in an increase in neuron viability by 20–30%
In other words, IMR32 cells treated by i-Extract, withanone or WEX protected the neuron integrity and viability against the oxidative activity of H2O2 that causes DNA damage to the brain cells.
On LDH assay analysis, Dr. Navjot Shah, the lead scientist said, " Similar to the viability assay, LDH assay also showed the least protective effect in case of withaferin A-treated cells. Furthermore, cell morphology endorsed that the i-Extract, withanone, and WEX protected IMR32 and C6 cells against H2O2 stress".
Taken altogether, Ashwagandha may be considered a functional herb that protects the neurons against the onset of neuroblastoma, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation by Navjot Shah, 1 Rumani Singh, 1 Upasana Sarangi, 1 Nishant Saxena, 1 Anupama Chaudhary, 1Gurcharan Kaur, 2 Sunil C. Kaul, 1,* and Renu Wadhwa. (PMC)
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.
Cancer most commonly affects children age 5 or younger compared to less often in older children.
According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.
And 90% of children affected by neuroblastoma are children younger than 5.
Sadly, the the-5-year survival rate of cancer is less than 50%.
The most common symptoms are totally depending on the area that has been effected* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched and changes in bowel habits, such as diarrhea or constipation.
* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain and changes to the eyes, including drooping eyelids and unequal pupil size
Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the protection of neurons, researchers examined the effects of ashwagandha root extract consumption on human neuroblastoma (IMR32).
Human neuroblastoma (IMR32) cells, pretreated with Ashwagandha-reagents for 24 h, were exposed to H2O2 (300 μM) for 2 h, before incubating in control or test medium supplemented with either the alcoholic (i-Extract) or water (WEX) extracts or their active components (withanone or withaferin A), showed a significant effect on H2O2 by 40%.
Furthermore, i-Extract, withanone or WEX also resulted in an increase in neuron viability by 20–30%
In other words, IMR32 cells treated by i-Extract, withanone or WEX protected the neuron integrity and viability against the oxidative activity of H2O2 that causes DNA damage to the brain cells.
On LDH assay analysis, Dr. Navjot Shah, the lead scientist said, " Similar to the viability assay, LDH assay also showed the least protective effect in case of withaferin A-treated cells. Furthermore, cell morphology endorsed that the i-Extract, withanone, and WEX protected IMR32 and C6 cells against H2O2 stress".
Taken altogether, Ashwagandha may be considered a functional herb that protects the neurons against the onset of neuroblastoma, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation by Navjot Shah, 1 Rumani Singh, 1 Upasana Sarangi, 1 Nishant Saxena, 1 Anupama Chaudhary, 1Gurcharan Kaur, 2 Sunil C. Kaul, 1,* and Renu Wadhwa. (PMC)
Friday, February 21, 2020
Bromelain Improves the Neurological Status in Post Acute Infarction
Acute brain infarction is the medical condition characterized by the obstruction of the blood supply to the brain, causing the local death of the brain tissue.
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.
The most common symptoms of acute brain infarction are trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm or leg, headache and the trouble with walking.
Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm or leg, trouble with seeing in one or both eyes.
Acute brain infarction is a medical emergency, Prompt treatment can minimize brain damage and potential complications.
There are many factors associated with the risk of acute infarction. However, aging may have a strong and negative implication on acute infarction.
Dr. Mehta RH, the lead scientist wrote, "Older age was associated with a greater proportion of patients with functional limitations, heart failure, prior coronary disease, and renal insufficiency and a lower proportion of male and diabetic patients".
And, "...age-associated differences in clinical characteristics in elderly patients with acute myocardial infarction (AMI), which account for some of the age-associated differences in mortality".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of complications after acute brain infarction, researchers examined the effect of Flogensim on the neurological status on 1st and 7 days after developing the disease.109 patients.
Where Flogenzim consists of highly active proteolytic enzymes containing bromelain, trypsin and of Rutinum.
According to the tested analysis, on day 7, Flogenzim treatment group showed a decrease in the concentration of I1-6, compared to control.
Where high levels of interleukin-6 (I1-6) is associated with postischemic inflammation in patients with acute brain infarction.
Furthermore, on day 21 among patients pertaining to a different group, the considerable difference in consequences were better increases in the treatment group.
More profoundly, the number of patients of Flogenzim group showed no dynamic or even worsening in neurological status decreases, compared to control.
Taken altogether, bromelain used alone or combined with other remedies may be considered a remedy for the improvement of neurological status, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Effect of flogensim in the treatment of postischemic inflammation (according to results of using interleukin-6 in patients with acute brain infarction)].[Article in Ukrainian] by Vinychuk SM, Cheren'ko TM. (PubMed)
(2) Acute myocardial infarction in the elderly: differences by age by Mehta RH1, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. (PubMed)
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.
The most common symptoms of acute brain infarction are trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm or leg, headache and the trouble with walking.
Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm or leg, trouble with seeing in one or both eyes.
Acute brain infarction is a medical emergency, Prompt treatment can minimize brain damage and potential complications.
There are many factors associated with the risk of acute infarction. However, aging may have a strong and negative implication on acute infarction.
Dr. Mehta RH, the lead scientist wrote, "Older age was associated with a greater proportion of patients with functional limitations, heart failure, prior coronary disease, and renal insufficiency and a lower proportion of male and diabetic patients".
And, "...age-associated differences in clinical characteristics in elderly patients with acute myocardial infarction (AMI), which account for some of the age-associated differences in mortality".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of complications after acute brain infarction, researchers examined the effect of Flogensim on the neurological status on 1st and 7 days after developing the disease.109 patients.
Where Flogenzim consists of highly active proteolytic enzymes containing bromelain, trypsin and of Rutinum.
According to the tested analysis, on day 7, Flogenzim treatment group showed a decrease in the concentration of I1-6, compared to control.
Where high levels of interleukin-6 (I1-6) is associated with postischemic inflammation in patients with acute brain infarction.
Furthermore, on day 21 among patients pertaining to a different group, the considerable difference in consequences were better increases in the treatment group.
More profoundly, the number of patients of Flogenzim group showed no dynamic or even worsening in neurological status decreases, compared to control.
Taken altogether, bromelain used alone or combined with other remedies may be considered a remedy for the improvement of neurological status, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Effect of flogensim in the treatment of postischemic inflammation (according to results of using interleukin-6 in patients with acute brain infarction)].[Article in Ukrainian] by Vinychuk SM, Cheren'ko TM. (PubMed)
(2) Acute myocardial infarction in the elderly: differences by age by Mehta RH1, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. (PubMed)
Herbal Artichoke Promotes Healthy Levels of Free Fatty Acids
Free fatty acids found in fats and oils and in cell membranes are the by-products produced in the metabolism of fat in adipose tissues.
In other words, free fatty acids are produced by breaking down fats into fatty acids, which can then be absorbed into the blood.
Fatty acids can be used as fuel for the cells if glucose is not available for energy.
Free fatty acids play a critical role in the maintenance of our body functioning, including
* Cell signaling through the formation of the of eicosanoids, a group of signaling molecules involved in the immune response.
* In metabolism, FFAs play essential roles in the regulation of energy metabolism and mediation of a wide range of metabolic processes.
* In cells, FFAs are used for the formation of cell membranes or walls.
* More importantly, FFAs also have a strong effect on the endothelial function and dysfunction.
Dr. Carmen Gonzalez, the lead scientist in the examination of the role of free fatty acids wrote, "FFARs have been targeted in drug development for the treatment of type 2 diabetes and metabolic syndrome. FFAs upregulate transcription of uncoupling proteins, increasing their expression in brain, cardiac, and skeletal muscle that may be protective or cytotoxic, depending on the cellular energy state".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belongings to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
With an aim to find a natural ingredient for the improvement of healthy levels of free fatty acids (FFAs) in humans, researchers examined the artichoke bracts (AB) in an animal model.
The study included a total of 120 rabbits aged 38 days divided into three groups fed with different isonitrogenous and isocaloric diets supplemented with AB at 0%, 5%, and 10%.
At 96 days of age, after observing the carcasses of 12 rabbits slaughtered in an experimental slaughterhouse without fasting, researchers found that the levels of α-linolenic acid proportion were decreased with the injection of AB supplementation from 3.58% to 2.59% in the LD muscle and from 4.74% to 3.62% in the perirenal fat.
Furthermore, the meat ether extract (FFAs) content also was increased from 0.68% to 0.94% on a fresh matter basis by the injection of AB supplementation.
The levels of n-6/n-3 ratio increased significantly with increasing AB inclusion from 7.15 to 10.20 in the LD muscle and from 6.68 to 9.35 in the perirenal fat.
The results suggested that artichoke has a strong impact on improving quality and fatty acid composition.
Moreover, in order to reveal additional information about artichoke on fatty acids, researchers launched an investigation of Nigella sativa, lupin and artichoke seed oils' fatty acids (FA, as methyl esters) using gas chromatographic analysis (GLC).
At the end of the experiment, researchers found that three seed oils are rich in FFAs including oleic and linoleic acid content.
According to the results from the high-pressure liquid chromatography (HPLC) assay, artichoke oil was unique in having a high content of 5-stigma-, 7-stigma-, and avenasterol compared to those of Nigella sativa, Lupin, particularly in levels of FSG and ASG.
The findings lead us to say that artichoke seed oil can be recommended as healthy oils and folk medicine, according to Dr. M Hassanein MM, the lead scientist at the National Research Centre, Fats, and Oils Dept, Egypt.
Taken altogether, artichoke (seed oils) may be considered a healthy choice of free fatty acids for reducing the risk of diseases associated with high blood pressure, insulin resistance, high triglycerides, and low “good” HDL cholesterol levels, pending to the validation of larger sample size and multicenter human study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Dried artichoke bracts in rabbits nutrition: effects on the carcass characteristics, meat quality and fatty-acid composition by Dabbou S1, Gasco L1, Gai F2, Zoccarato I1, Rotolo L1, Dabbou Fekih S3, Brugiapaglia A1, Helal AN3, Peiretti PG. (PubMed)
(2) Investigation of lipids profiles of Nigella, lupin and artichoke seed oils to be used as healthy oils by M Hassanein MM1, El-Shami SM, El-Mallah MH. (PubMed)
(3) Role of Free Fatty Acids in Physiological Conditions and Mitochondrial Dysfunction by Zbigniew K. Binienda, Sumit Sarkar, Sonia Silva-Ramirez, Carmen Gonzalez. (Scientific Research)
Thursday, February 20, 2020
Herbal Ashwagandha, the Anti Male Infertility Functional Remedy
Fertility is a natural process to ensure the survival of human species. Through natural selection, we produce many offsprings when the reproductive system works at its peak in a suitable environment.
In other words, female fertility is the ability of women to conceive a biological child before menopause compared to male fertility which generally relies on the quantity and quality of the sperms.
But regardless of all factors, most women are capable of conceiving during their menstrual cycle before reaching the stage of menopause.
Infertility is a condition characterized by the inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to term.
The condition affects over 5 millions couples alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seek help from a professional specialist.
Male infertility is a medical condition associated with the male's inability to cause pregnancy in a fertile female.
Male infertility accounts for 40–50% of all cases of infertility, affecting over 7% of all men.
Most cases of male infertility are the results of deficiencies in the semen, and semen quality that lead to reduced function of male fecundity.
The exact causes of male infertility are not identified. However, abnormal sperm production or function due to genetic defects, and medical conditions such as diabetes, or infectious diseases such as chlamydia, gonorrhea, mumps are some of the prevalent factors that are involved in the increased risk of male infertility.
Believe it or not, stress caused by a number of health problems, including heart disease, asthma, obesity, and depression may lead to reduce sperm and semen quality in male fertility.
Dr. Nargund VH said, "Psychological stress can be defined as any uncomfortable 'emotional experience' accompanied by predictable biochemical, physiological and behavioral changes or responses. Many clinical studies looking at the effects of psychological stress on male fertility have shown that stress is associated with reduced paternity and abnormal semen parameters".
And, "psychological stress could severely affect spermatogenesis, mainly as a result of varying testosterone secretion. The hypothalamic-pituitary-adrenal axis has a direct inhibitory action on the hypothalamic-pituitary-gonadal (HPG) axis and Leydig cells in the testes. The newly discovered hormone, gonadotropin-inhibitory hormone (GnIH), also has an inhibitory effect on the HPG axis. Inhibition of the HPG axis results in a fall in testosterone levels, which causes changes in Sertoli cells and the blood-testis barrier, leading to the arrest of spermatogenesis".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potential compound for the improvement of male fertility, researchers examined the efficacy and safety of W. somnifera treatment in infertile men.
The evidence-based systematic review and meta-analysis were conducted by searching the database of medical literature PubMed/MEDLINE, EMBASE, Scopus, the Cochrane Library, and DHARA. Grey literature was assessed from the WHO International Clinical Trials Registry Platform (http://apps.who.int/trialsearch/) and the US National Institutes of Health (https://clinicaltrials.gov/).
According to the 4 clinical trials (comprising 5 publications: observational, n = 4; randomized controlled trial [RCT], n = 1) only one RCT were included in the analysis, W. somnifera treatment significantly improved semen parameters including semen volume: mean difference [MD], 0.28 ml; sperm concentration: MD, 13.57 million/ml; sperm motility: MD, 8.50%
Furthermore, W. somnifera administration also improve the fertility rate in normozoospermic men by 14%
Moreover, according to the results of meta-analysis, W. somnifera treatment also exerted a significant improvement in serum hormonal profile, oxidative biomarkers and antioxidant vitamins in seminal plasma.
No adverse effects were reported during the study.
In other words, W. somnifera enhances all parameters associated with sperm integrity and viability in the promotion of conception without inducing any side effects.
Based on the findings, researchers after taking other factors into account wrote, "Due to a small number of eligible studies, the available data, though promising, are too limited to provide novel and sufficiently robust evidence of the benefits of W. somnifera in male infertility. Additional RCTs of high quality with a larger sample size are warranted to further strength clinical use of W. somnifera in treating male factor infertility".
Taken altogether, Ashwagandha may be considered a remedy for the treatment of male infertility, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Role of Withania somnifera (Ashwagandha) in the management of male infertility by Sengupta P1, Agarwal A2, Pogrebetskaya M3, Roychoudhury S4, Durairajanayagam D5, Henkel R. (PubMed)
(2) Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis by Durg S1, Shivaram SB2, Bavage S. (PubMed)
(3) Effects of psychological stress on male fertility by Nargund VH. (PubMed)
In other words, female fertility is the ability of women to conceive a biological child before menopause compared to male fertility which generally relies on the quantity and quality of the sperms.
But regardless of all factors, most women are capable of conceiving during their menstrual cycle before reaching the stage of menopause.
Infertility is a condition characterized by the inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to term.
The condition affects over 5 millions couples alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seek help from a professional specialist.
Male infertility is a medical condition associated with the male's inability to cause pregnancy in a fertile female.
Male infertility accounts for 40–50% of all cases of infertility, affecting over 7% of all men.
Most cases of male infertility are the results of deficiencies in the semen, and semen quality that lead to reduced function of male fecundity.
The exact causes of male infertility are not identified. However, abnormal sperm production or function due to genetic defects, and medical conditions such as diabetes, or infectious diseases such as chlamydia, gonorrhea, mumps are some of the prevalent factors that are involved in the increased risk of male infertility.
Believe it or not, stress caused by a number of health problems, including heart disease, asthma, obesity, and depression may lead to reduce sperm and semen quality in male fertility.
Dr. Nargund VH said, "Psychological stress can be defined as any uncomfortable 'emotional experience' accompanied by predictable biochemical, physiological and behavioral changes or responses. Many clinical studies looking at the effects of psychological stress on male fertility have shown that stress is associated with reduced paternity and abnormal semen parameters".
And, "psychological stress could severely affect spermatogenesis, mainly as a result of varying testosterone secretion. The hypothalamic-pituitary-adrenal axis has a direct inhibitory action on the hypothalamic-pituitary-gonadal (HPG) axis and Leydig cells in the testes. The newly discovered hormone, gonadotropin-inhibitory hormone (GnIH), also has an inhibitory effect on the HPG axis. Inhibition of the HPG axis results in a fall in testosterone levels, which causes changes in Sertoli cells and the blood-testis barrier, leading to the arrest of spermatogenesis".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potential compound for the improvement of male fertility, researchers examined the efficacy and safety of W. somnifera treatment in infertile men.
The evidence-based systematic review and meta-analysis were conducted by searching the database of medical literature PubMed/MEDLINE, EMBASE, Scopus, the Cochrane Library, and DHARA. Grey literature was assessed from the WHO International Clinical Trials Registry Platform (http://apps.who.int/trialsearch/) and the US National Institutes of Health (https://clinicaltrials.gov/).
According to the 4 clinical trials (comprising 5 publications: observational, n = 4; randomized controlled trial [RCT], n = 1) only one RCT were included in the analysis, W. somnifera treatment significantly improved semen parameters including semen volume: mean difference [MD], 0.28 ml; sperm concentration: MD, 13.57 million/ml; sperm motility: MD, 8.50%
Furthermore, W. somnifera administration also improve the fertility rate in normozoospermic men by 14%
Moreover, according to the results of meta-analysis, W. somnifera treatment also exerted a significant improvement in serum hormonal profile, oxidative biomarkers and antioxidant vitamins in seminal plasma.
No adverse effects were reported during the study.
In other words, W. somnifera enhances all parameters associated with sperm integrity and viability in the promotion of conception without inducing any side effects.
Based on the findings, researchers after taking other factors into account wrote, "Due to a small number of eligible studies, the available data, though promising, are too limited to provide novel and sufficiently robust evidence of the benefits of W. somnifera in male infertility. Additional RCTs of high quality with a larger sample size are warranted to further strength clinical use of W. somnifera in treating male factor infertility".
Taken altogether, Ashwagandha may be considered a remedy for the treatment of male infertility, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Role of Withania somnifera (Ashwagandha) in the management of male infertility by Sengupta P1, Agarwal A2, Pogrebetskaya M3, Roychoudhury S4, Durairajanayagam D5, Henkel R. (PubMed)
(2) Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis by Durg S1, Shivaram SB2, Bavage S. (PubMed)
(3) Effects of psychological stress on male fertility by Nargund VH. (PubMed)
Bromelain Kills Mammary Cancer Cells in Vitro
A mammary tumor is a medical and chronic condition originated from the milk-producing gland.
The mammary gland located in the breasts of females is responsible for lactation.
Most cases of the mammary cancer are first found in the cell on the surface of the inner lining of the milk-producing gland, before penetrating deeper into the layers.
At the advanced stage, the malignant cancer cells can also travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.
Epidemiologically, mammary cancer has been found to spread to the colon and the liver.
Most common risk factors of mammary cancer are similar to those of breast cancer, inclduing, aging, physical inactivity, being obese or overweight, family and personal history, having a dense breast, radiation therapy, pregnancy history, genetic proposition, particularly in women who had used drug diethylstilbestrol (DES).
Out of all the aforementioned risk factors, some researchers suggested that the promotion of high-fat-diet-induced a high percentage of obese US females may be the major culprit that causes the rise of mammary cancer.
Dr. Valeria Simone, the lead scientist in the examination of the molecule interconnection of obesity and breast cancer risk wrote, "Obesity is an important risk factor for breast cancer (BC) in postmenopausal women; interlinked molecular mechanisms might be involved in the pathogenesis. Increased levels of estrogens due to aromatization of the adipose tissue, inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and prostaglandin E2, insulin resistance and hyperactivation of insulin-like growth factors pathways, adipokines, and oxidative stress are all abnormally regulated in obese women and contribute to cancerogenesis".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against mammary carcinoma, researchers examined the bromelain autophagic phenomenon in mammary carcinoma cells (estrogen receptor positive and negative).
According to the tested assays, bromelain showed delayed growth inhibitory response and induction of autophagy, in MCF-7 cells.
Bromelain induced cancer cells apoptosis was found in the sub-G1 cell fraction and apoptotic features associated with chromatin condensation change and cell division.
Interestingly, in the presence of an anti-apoptotic protein that augments the autophagy levels, bromelain inhibited morphological apoptosis but did not prevent cell death.
In other words, bromelain induced cancer cell death by inhibiting the expression of signaling cascade associated with the phosphorylation of extracellular signal-regulated kinase ½ (ERK½) and exhibiting the proapoptotic kinases (c-jun N-terminal kinase (JNK) and p38 kinase).
Based on the findings, researchers said, "bromelain-induced autophagy was positively regulated by p38 and JNK but negatively regulated by ERK½. Autophagy-inducing property of bromelain can be further exploited in breast cancer therapy".
In order to reveal more information about bromelain anti mammary carcinoma property, researchers examined the enzyme effect on GI-101A breast cancer cells.
According to the results from GI-101A cells treated with increasing concentrations of bromelain for 24 hours, bromelain induced cancer cell death via activation of the apoptosis mechanisms.
Observation of the results from the caspase-9 and caspase-3 assays, bromelain exhibited a prominent effect to induce cancer cell apoptosis correlated with the elevation of plasma cytokeratin 18 (CK-18) fragment levels, a marker of cell death.
The inhibition of bromelain against cancer cell proliferation was also evident by the DNA fragmentation analysis and 4,6'-diamino-2-phenylindole dihydrochloride fluorescence staining of the nucleus.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of mammary carcinoma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells by Bhui K1, Tyagi S, Prakash B, Shukla Y. (PubMed)
(2) Bromelain-induced apoptosis in GI-101A breast cancer cells by Dhandayuthapani S1, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A. (PubMed)
(3) Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications
by Valeria Simone, Morena D’Avenia, Antonella Argentiero, Claudia Felici,Francesca Maria Rizzo, Giovanni De Pergola and Franco Silvestris. (The Oncologist)
The mammary gland located in the breasts of females is responsible for lactation.
Most cases of the mammary cancer are first found in the cell on the surface of the inner lining of the milk-producing gland, before penetrating deeper into the layers.
At the advanced stage, the malignant cancer cells can also travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.
Epidemiologically, mammary cancer has been found to spread to the colon and the liver.
Most common risk factors of mammary cancer are similar to those of breast cancer, inclduing, aging, physical inactivity, being obese or overweight, family and personal history, having a dense breast, radiation therapy, pregnancy history, genetic proposition, particularly in women who had used drug diethylstilbestrol (DES).
Out of all the aforementioned risk factors, some researchers suggested that the promotion of high-fat-diet-induced a high percentage of obese US females may be the major culprit that causes the rise of mammary cancer.
Dr. Valeria Simone, the lead scientist in the examination of the molecule interconnection of obesity and breast cancer risk wrote, "Obesity is an important risk factor for breast cancer (BC) in postmenopausal women; interlinked molecular mechanisms might be involved in the pathogenesis. Increased levels of estrogens due to aromatization of the adipose tissue, inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and prostaglandin E2, insulin resistance and hyperactivation of insulin-like growth factors pathways, adipokines, and oxidative stress are all abnormally regulated in obese women and contribute to cancerogenesis".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against mammary carcinoma, researchers examined the bromelain autophagic phenomenon in mammary carcinoma cells (estrogen receptor positive and negative).
According to the tested assays, bromelain showed delayed growth inhibitory response and induction of autophagy, in MCF-7 cells.
Bromelain induced cancer cells apoptosis was found in the sub-G1 cell fraction and apoptotic features associated with chromatin condensation change and cell division.
Interestingly, in the presence of an anti-apoptotic protein that augments the autophagy levels, bromelain inhibited morphological apoptosis but did not prevent cell death.
In other words, bromelain induced cancer cell death by inhibiting the expression of signaling cascade associated with the phosphorylation of extracellular signal-regulated kinase ½ (ERK½) and exhibiting the proapoptotic kinases (c-jun N-terminal kinase (JNK) and p38 kinase).
Based on the findings, researchers said, "bromelain-induced autophagy was positively regulated by p38 and JNK but negatively regulated by ERK½. Autophagy-inducing property of bromelain can be further exploited in breast cancer therapy".
In order to reveal more information about bromelain anti mammary carcinoma property, researchers examined the enzyme effect on GI-101A breast cancer cells.
According to the results from GI-101A cells treated with increasing concentrations of bromelain for 24 hours, bromelain induced cancer cell death via activation of the apoptosis mechanisms.
Observation of the results from the caspase-9 and caspase-3 assays, bromelain exhibited a prominent effect to induce cancer cell apoptosis correlated with the elevation of plasma cytokeratin 18 (CK-18) fragment levels, a marker of cell death.
The inhibition of bromelain against cancer cell proliferation was also evident by the DNA fragmentation analysis and 4,6'-diamino-2-phenylindole dihydrochloride fluorescence staining of the nucleus.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of mammary carcinoma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells by Bhui K1, Tyagi S, Prakash B, Shukla Y. (PubMed)
(2) Bromelain-induced apoptosis in GI-101A breast cancer cells by Dhandayuthapani S1, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A. (PubMed)
(3) Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications
by Valeria Simone, Morena D’Avenia, Antonella Argentiero, Claudia Felici,Francesca Maria Rizzo, Giovanni De Pergola and Franco Silvestris. (The Oncologist)
Wednesday, February 19, 2020
Ginger Processes Anti Cancer Potential, Scientists Suggest
Scientists may have found a pungent kitchen spice that processes the potency for the prevention and treatment of cancers, some studies found.
Cancer is the class of chronic illness characterized by cell growth disorderly and uncontrollably on some tissue and organs in the body.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissue or organs in the early stage.
Most patients in this stage depending on the type of cancer do not experience any symptoms. However, at the advanced stage, as the tumor has penetrated deeply into the layers of tissue, most cancer can suppress the nearby tissue and nerve cells, causing localized symptoms and severe pain.
At this stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs.
The exact causes of cancer are unknown. Epidemiological studies, depending on the type of cancer suggested that aging, sun exposure, radiation exposure, toxic chemicals viruses and bacteria, certain hormones, family history of cancer are some most common prevalent risk factors of cancer.
Some researchers suggested. obesity or overweight, poor diet, and lifestyle are the most common preventable risk factors associated with cancer onset in the US.
According to the statistic, approximately 200,000 new cancer diagnoses and 80,800 deaths from cancer in Canada in 2017.
Lung, colorectal, breast, and prostate cancer are accounted for about half of all cancer diagnoses and deaths.
About 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.
In the concern of the prevalence of overweight and obesity is increasing worldwide and a link between obesity and cancer is growing, Dr. Karen Basen-Engquis, the lead author launched an investigation to examine the obesity and cancer risk.
At the final report of the experiment, the team said, " Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%." and "Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
And, "Numerous cohort studies, summarized in systematic reviews, have shown a link between obesity and cancer incidence overall and for selected cancer sites (eg, endometrial, postmenopausal breast, colon, and esophageal adenocarcinoma)".
These results clearly suggested the risk of cancer is elevated in the obese and overweight population compared to healthy weight individuals.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding a natural whole food for the treatment of cancer with no side effects, researchers looked into the ginger antiemetic and anticancer activities.
By examing the phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, researchers suggested that the content of 6-shogaol found very low in fresh ginger, but significantly higher after steaming exerts a significant anti-cancer activity.
Dr. Wang CZ, after taking into account co and confounders, said, "6-shogaol can be served as a lead compound for new drug discovery" and " The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from the ginger".
Furthermore, in the examination of the plant-derived exosome-like nanoparticles, a promising substitution and exhibit anti-cancer biocompatibility through oral, intranasal administration, researchers looked into ligands from the ginger.
The application of ligands from the ginger demonstrated an anticancer effect by the ability to exhibit the gene expression in T-cells with siRNAs through activating innate immune responses.
These results suggested that ligands on ginger derived exosome-like nanovesicles (GDENs) inhibit tumor growth on a xenograft model by intravenous administration.
Taken together, ginger processed ligands on ginger derived exosome-like nanovesicles (GDENs)and 6-shogaol may be considered a function for the prevention and combined with primary therapy for the treatment of cancer without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery by Wang CZ1, Qi LW1,2, Yuan CS. (PubMed)
(2) Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology by Ghasemzadeh A1, Jaafar HZ2, Rahmat A. (PubMed)
(3) Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression by Li Z1, Wang H1, Yin H1, Bennett C2, Zhang HG3, Guo P. (PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Cancer is the class of chronic illness characterized by cell growth disorderly and uncontrollably on some tissue and organs in the body.
Most cases of cancer start in the cells on the surface of the inner lining of specific tissue or organs in the early stage.
Most patients in this stage depending on the type of cancer do not experience any symptoms. However, at the advanced stage, as the tumor has penetrated deeply into the layers of tissue, most cancer can suppress the nearby tissue and nerve cells, causing localized symptoms and severe pain.
At this stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs.
The exact causes of cancer are unknown. Epidemiological studies, depending on the type of cancer suggested that aging, sun exposure, radiation exposure, toxic chemicals viruses and bacteria, certain hormones, family history of cancer are some most common prevalent risk factors of cancer.
Some researchers suggested. obesity or overweight, poor diet, and lifestyle are the most common preventable risk factors associated with cancer onset in the US.
According to the statistic, approximately 200,000 new cancer diagnoses and 80,800 deaths from cancer in Canada in 2017.
Lung, colorectal, breast, and prostate cancer are accounted for about half of all cancer diagnoses and deaths.
About 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.
In the concern of the prevalence of overweight and obesity is increasing worldwide and a link between obesity and cancer is growing, Dr. Karen Basen-Engquis, the lead author launched an investigation to examine the obesity and cancer risk.
At the final report of the experiment, the team said, " Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%." and "Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
And, "Numerous cohort studies, summarized in systematic reviews, have shown a link between obesity and cancer incidence overall and for selected cancer sites (eg, endometrial, postmenopausal breast, colon, and esophageal adenocarcinoma)".
These results clearly suggested the risk of cancer is elevated in the obese and overweight population compared to healthy weight individuals.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding a natural whole food for the treatment of cancer with no side effects, researchers looked into the ginger antiemetic and anticancer activities.
By examing the phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, researchers suggested that the content of 6-shogaol found very low in fresh ginger, but significantly higher after steaming exerts a significant anti-cancer activity.
Dr. Wang CZ, after taking into account co and confounders, said, "6-shogaol can be served as a lead compound for new drug discovery" and " The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from the ginger".
Furthermore, in the examination of the plant-derived exosome-like nanoparticles, a promising substitution and exhibit anti-cancer biocompatibility through oral, intranasal administration, researchers looked into ligands from the ginger.
The application of ligands from the ginger demonstrated an anticancer effect by the ability to exhibit the gene expression in T-cells with siRNAs through activating innate immune responses.
These results suggested that ligands on ginger derived exosome-like nanovesicles (GDENs) inhibit tumor growth on a xenograft model by intravenous administration.
Taken together, ginger processed ligands on ginger derived exosome-like nanovesicles (GDENs)and 6-shogaol may be considered a function for the prevention and combined with primary therapy for the treatment of cancer without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery by Wang CZ1, Qi LW1,2, Yuan CS. (PubMed)
(2) Optimization protocol for the extraction of 6-gingerol and 6-shogaol from Zingiber officinale var. rubrum Theilade and improving antioxidant and anticancer activity using response surface methodology by Ghasemzadeh A1, Jaafar HZ2, Rahmat A. (PubMed)
(3) Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression by Li Z1, Wang H1, Yin H1, Bennett C2, Zhang HG3, Guo P. (PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Subscribe to:
Posts (Atom)