Scientists may have found a medicinal remedy for the prevention and treatment of cancer with no side effects, according to studies.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable ways in our body, due to the change of cellular DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ. At the 0 stage, due to the very small size of the tumor, most patients so not experience any symptoms.
However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.
Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Symptoms of cancer at this stage are totally dependent on the affected area, including vomiting blood in oral and lung cancer blood in the urine in bladder cancer. hoarseness in throat cancer. ... Persistent lumps in the breast and lymph cancer and indigestion or difficulty swallowing in digestive related cancers.
Researchers do not know the exact causes of cancers, but they do know, according to epidemiological studies that age, alcohol cancer, chronic Inflammation, genetic proposition, unhealthy diet, change of hormones use of immunosuppression, infectious agents, obesity, exposure to radiation and sunlight, use of tobacco are most common risk factors associated with the onset of some specific cancers.
Some researchers in the investigation of weakened immune function in the risk of cancer suggested people with a weakened immune system lost the function
1) to stimulate the T cells inactivation of the B cells in the production of p53, a tumor suppressor gene, or antioncogene that inhibits the cancer cell proliferation and tumor development and
2) to stimulate the production of pro-inflammatory cytokines to kill off the DNA alternated damage cells in the acute phase of inflammation.
In other words, if you have a strong immune system, your risk of cancer is substantially lower compared to the general public.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere. the herbal plant has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The Shandong University at Weihai, on finding a natural compound for the treatment of cancer with no side effects examined a new bakkenolide isolated from Butterbur anti-cancer effects.
The new bakkenolide exerted a potent cytotoxic activity against a number of cultured human cancer cells, including human cervical carcinoma (HeLa), human breast cancer (MCF-7) and murine Lewis lung carcinoma (LLC) cell lines.
According to the National Veterinary Research and Quarantine Service in vitro methanol extract from the leaves in the rat liver epithelial cells. significantly decreased spontaneous beta-galactosidase activity and beta-galactosidase activity induced by a mutagen.
Elevated beta-galactosidase (beta-gal) enzyme activity is an indication of the tumor and metastatic expression.
All doses of the extract (0.08-100 mg/plate) decreased the reversion frequency induced by benzo (alpha)pyrene (BaP) in S. Typhimurium TA 98 of the Salmonella typhimurium.
Additional analysis of the experiment, PJ extract showed greater cytotoxic effects on the human stomach, colon, and uterus cancer cells than on other cancer cell types and normal rat liver epithelial cells.
Furthermore, PJ significantly increased the numbers of gap junction proteins associated with tumor suppression in a dose-dependent manner.
Dr. the lead scientist said, "Based on these findings, PJ is suggested to contain antimutagenic and anticarcinogenic compounds".
Taken altogether, herbal Butterbur may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of cancers.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bakkenolides from Petasites tatewakianus by Dong XW, Li RJ, Gao X, Row KH.(PubMed)
(2) Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves by Kang HG, Jeong SH, Cho JH.(PubMed)
(3) Interactions between the tumor suppressor p53 and immune responses by Menendez D1, Shatz M, Resnick MA. (PubMed)
Monday, February 24, 2020
Herbal Bilberry, the Anti-Obesity Functional Food in Animal and Human Study
On seeking natural therapy with no side effects, scientists may have a herbal remedy that visceral fat accumulation in obesity, according to studies.
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.
Obesity is a medical condition caused by excess body fat accumulated to an extent that impact personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.
Obesity rates have increased for all population groups in the US over the last several decades, coincidently with the periods in the promotion of the Western diet.
Dr. Maximilian Tremmel, the lead scientist in the investigation of economic burden in obesity wrote, "The rising prevalence of obesity represents an important public health issue. An assessment of its costs may be useful in providing recommendations for policy and decision-makers" and "there was great variety in the included obesity-related diseases and complications among the studies".
And, "There is an urgent need for public health measures to prevent obesity in order to save societal resources. Moreover, international consensus is required on standardized methods to calculate the cost of obesity to improve homogeneity and comparability".
The findings strongly suggested that widespread obesity has caused significant pressure in the public health care system and an impact in the financial and economic burden.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural remedy for the treatment of obesity, researchers examined the effects of anthocyanin-rich phytochemicals found in aronia fruits (aronia phytochemicals) and bilberry in high-fat-diet-induced dietary obese rats.
During the study, bilberry phytochemicals-supplemented rats showed a significant reduction of total visceral fat mass but to a lesser extent compared to aronia phytochemicals.
Similarly, perirenal and epididymal adipose tissue mass in rats fed aronia phytochemicals was by far greater than the bilberry phytochemicals group.
Bilberry lowered the mesenteric adipose tissue mass.
Bilberry also exerted the equivalently inhibited the increases in plasma triglyceride levels, compared to that of aronia phytochemicals with a half-maximal inhibitory concentration (IC(50)) of 1.50 mg/mL.
The results suggest that anthocyanin-rich phytochemicals in aronia fruits and bilberry may have a potency for the treatment of obesity through suppressing the visceral fat accumulation and hyperglycemia.
In order to reveal more information about bilberry anti-obesity property, researchers evaluated a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults.
Participants (N = 103, 18-65 y, BMI ≥ 25 kg/m2) included in the study were randomized to flavonoid (F) or placebo (P) groups for 12 weeks with blood and 24 h urine samples collected prestudy and after 4 and 12 weeks in a parallel design.
The supplement included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega 3 fatty acids.
According to the urinary assay, the 4 weeks, urine total phenolics increased 24% in F versus P with similar changes at 12 weeks.
In of F demonstrated the shifts in 63 biochemicals compared to P with 70% from the lipid and xenobiotics super-pathways, according to the examination of metabolomics assay.
Where metabolite profile is reflective of metabolic processes, including pathophysiological changes characteristic of obesity-related complications.
The findings suggested that flavonoid-rich supplements may have a strong effect on the change of metabolome which is the sum of all the small-molecule chemicals found in a biological sample, often the blood plasma and considered a measurement of obesity and health beyond BMI.
Taken altogether, bilberry used alone or combined with other agents may be considered functional remedies for the prevention and treatment of obesity, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats by Takahashi A1, Shimizu H, Okazaki Y, Sakaguchi H, Taira T, Suzuki T, Chiji H. (PubMed)
(2) Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women by Nieman DC1, Ramamoorthy S2, Kay CD3, Goodman CL1, Capps CR1, Shue ZL1, Heyl N1, Grace MH3, Lila MA. (PubMed)
(3) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.
Obesity is a medical condition caused by excess body fat accumulated to an extent that impact personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.
Obesity rates have increased for all population groups in the US over the last several decades, coincidently with the periods in the promotion of the Western diet.
Dr. Maximilian Tremmel, the lead scientist in the investigation of economic burden in obesity wrote, "The rising prevalence of obesity represents an important public health issue. An assessment of its costs may be useful in providing recommendations for policy and decision-makers" and "there was great variety in the included obesity-related diseases and complications among the studies".
And, "There is an urgent need for public health measures to prevent obesity in order to save societal resources. Moreover, international consensus is required on standardized methods to calculate the cost of obesity to improve homogeneity and comparability".
The findings strongly suggested that widespread obesity has caused significant pressure in the public health care system and an impact in the financial and economic burden.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural remedy for the treatment of obesity, researchers examined the effects of anthocyanin-rich phytochemicals found in aronia fruits (aronia phytochemicals) and bilberry in high-fat-diet-induced dietary obese rats.
During the study, bilberry phytochemicals-supplemented rats showed a significant reduction of total visceral fat mass but to a lesser extent compared to aronia phytochemicals.
Similarly, perirenal and epididymal adipose tissue mass in rats fed aronia phytochemicals was by far greater than the bilberry phytochemicals group.
Bilberry lowered the mesenteric adipose tissue mass.
Bilberry also exerted the equivalently inhibited the increases in plasma triglyceride levels, compared to that of aronia phytochemicals with a half-maximal inhibitory concentration (IC(50)) of 1.50 mg/mL.
The results suggest that anthocyanin-rich phytochemicals in aronia fruits and bilberry may have a potency for the treatment of obesity through suppressing the visceral fat accumulation and hyperglycemia.
In order to reveal more information about bilberry anti-obesity property, researchers evaluated a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults.
Participants (N = 103, 18-65 y, BMI ≥ 25 kg/m2) included in the study were randomized to flavonoid (F) or placebo (P) groups for 12 weeks with blood and 24 h urine samples collected prestudy and after 4 and 12 weeks in a parallel design.
The supplement included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega 3 fatty acids.
According to the urinary assay, the 4 weeks, urine total phenolics increased 24% in F versus P with similar changes at 12 weeks.
In of F demonstrated the shifts in 63 biochemicals compared to P with 70% from the lipid and xenobiotics super-pathways, according to the examination of metabolomics assay.
Where metabolite profile is reflective of metabolic processes, including pathophysiological changes characteristic of obesity-related complications.
The findings suggested that flavonoid-rich supplements may have a strong effect on the change of metabolome which is the sum of all the small-molecule chemicals found in a biological sample, often the blood plasma and considered a measurement of obesity and health beyond BMI.
Taken altogether, bilberry used alone or combined with other agents may be considered functional remedies for the prevention and treatment of obesity, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats by Takahashi A1, Shimizu H, Okazaki Y, Sakaguchi H, Taira T, Suzuki T, Chiji H. (PubMed)
(2) Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women by Nieman DC1, Ramamoorthy S2, Kay CD3, Goodman CL1, Capps CR1, Shue ZL1, Heyl N1, Grace MH3, Lila MA. (PubMed)
(3) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)
Sunday, February 23, 2020
Healthy Food Cranberry Protects the Heart Against Cardiovascular Toxicity
Cardiac toxicity is a condition in which the heart has been damage to some extents caused by harmful chemicals, including toxins induced by the treatment of chemotherapy, leading to reduced heart muscles function to pump blood and heart failure.
Long term intake of certain medication and people who are under treatment of chemotherapy have been found in most cases of cardiotoxicity.
Dr. Polonsky TS, the lead scientist wrote, "Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy".
And, "Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity".
Additionally, human immunodeficiency virus (HIV) infection, genetic preposition, a malignant disease associated with the amyloid deposited on the heart or other organs, high blood pressure, untreated hyperthyroidism, and vitamin b2 deficiency are some of the most prevalent factors found in patients with cardiotoxicity.
Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes
* Cardiomyopathy is a disorder caused a weaken or damage of heart muscle, affecting the heart rhythm or inducing the risk of heart failure.
* Myocarditis is a condition of inflammation of the heart, that can lead to changes in heart rhythm or heart failure.
* Pericarditis is a condition caused by the inflammation of the sac surrounding the heart, inducing chest pain or heart failure.
* Acute coronary syndromes that affect the blood flow due to blood vessel damage.
* Congestive heart failure is a result that affects the function of the heart in pumping blood throughout the body.
Most common symptoms of cardiotoxicity are associated with not enough blood circulation in the body such as tiredness and fatigue, a long-term (chronic) cough, shortness of breath, floating due to the enlarged heart muscle, abnormal heart or lung sounds and swelling in your hands, feet, or unusual weight gain.
Conventionally, treatment of cardiotoxicity is totally depending on the types of the disease including
Beta-blockers, ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow and diuretics.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cardiovascular diseases, researchers examined the protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in an animal model.
According to the results of rats were given CRAN orally (100mg/kg/day for 10 consecutive days) and DOX (15mg/kg; i.p.) for 7 days, CRAN protected the heart function against DOX-induced increased mortality and ECG changes.
The reduced levels of antioxidants enzymes and increased oxidative stress in the cardiac tissues induced by DOX such as glutathione (GSH) depletion and oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls were significantly inhibited by the administration of CRAN.
Furthermore, the reduced cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) induced by DOX were also inhibited by CRAN.
Moreover, CRAN also improved the cardiac myeloperoxidase (MPO) activity against infection compared to untreated rats.
Most important, CRAN also normalized the levels of enzymes associated with cardio muscle damage and injury casued by DOX such as troponin I, creatine phosphokinase (CK), and creatine kinase-MB.
Based on the findings, researchers said, "CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats".
Taken altogether, cranberry may be considered a remedy for the protection of cardiovascular toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats by Elberry AA1, Abdel-Naim AB, Abdel-Sattar EA, Nagy AA, Mosli HA, Mohamadin AM, Ashour O.M. (PubMed)
(2) Risk factors for chemotherapy-related cardiac toxicity by Polonsky TS1, DeCara JM. (PubMed)
Long term intake of certain medication and people who are under treatment of chemotherapy have been found in most cases of cardiotoxicity.
Dr. Polonsky TS, the lead scientist wrote, "Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy".
And, "Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity".
Additionally, human immunodeficiency virus (HIV) infection, genetic preposition, a malignant disease associated with the amyloid deposited on the heart or other organs, high blood pressure, untreated hyperthyroidism, and vitamin b2 deficiency are some of the most prevalent factors found in patients with cardiotoxicity.
Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes
* Cardiomyopathy is a disorder caused a weaken or damage of heart muscle, affecting the heart rhythm or inducing the risk of heart failure.
* Myocarditis is a condition of inflammation of the heart, that can lead to changes in heart rhythm or heart failure.
* Pericarditis is a condition caused by the inflammation of the sac surrounding the heart, inducing chest pain or heart failure.
* Acute coronary syndromes that affect the blood flow due to blood vessel damage.
* Congestive heart failure is a result that affects the function of the heart in pumping blood throughout the body.
Most common symptoms of cardiotoxicity are associated with not enough blood circulation in the body such as tiredness and fatigue, a long-term (chronic) cough, shortness of breath, floating due to the enlarged heart muscle, abnormal heart or lung sounds and swelling in your hands, feet, or unusual weight gain.
Conventionally, treatment of cardiotoxicity is totally depending on the types of the disease including
Beta-blockers, ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow and diuretics.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cardiovascular diseases, researchers examined the protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in an animal model.
According to the results of rats were given CRAN orally (100mg/kg/day for 10 consecutive days) and DOX (15mg/kg; i.p.) for 7 days, CRAN protected the heart function against DOX-induced increased mortality and ECG changes.
The reduced levels of antioxidants enzymes and increased oxidative stress in the cardiac tissues induced by DOX such as glutathione (GSH) depletion and oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls were significantly inhibited by the administration of CRAN.
Furthermore, the reduced cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) induced by DOX were also inhibited by CRAN.
Moreover, CRAN also improved the cardiac myeloperoxidase (MPO) activity against infection compared to untreated rats.
Most important, CRAN also normalized the levels of enzymes associated with cardio muscle damage and injury casued by DOX such as troponin I, creatine phosphokinase (CK), and creatine kinase-MB.
Based on the findings, researchers said, "CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats".
Taken altogether, cranberry may be considered a remedy for the protection of cardiovascular toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats by Elberry AA1, Abdel-Naim AB, Abdel-Sattar EA, Nagy AA, Mosli HA, Mohamadin AM, Ashour O.M. (PubMed)
(2) Risk factors for chemotherapy-related cardiac toxicity by Polonsky TS1, DeCara JM. (PubMed)
Bromelain, Inhibits Melanoma in Vitro and Vivo
Melanoma is a type of skin cancer caused by the alternation of DNA of the cells from the pigment-containing cells known as melanocytes.
Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.
The most common sites of melanoma metastasis are the lung and breast.
Most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.
If you are experiencing some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.
Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.
Compared to African Americans, melanoma is more than 20 times more common in whites.
Out of many risk factors associated with the onset of melanoma, some researchers suggested the misunderstanding of the health benefits and adverse effects of sun and tanning exposure may be the leading cause of melanoma.
Dr. Caroline Chang, the lead scientist said, "Despite advances in its detection and treatment, melanoma remains the primary cause of mortality from skin disease in the Western world.".
And, "Several personal risk factors for developing melanoma are well established, including family history, multiple moles, fair skin, blue eyes, red hair, and freckles.3Environmental exposures, chiefly from UV radiation, including outdoor sunburns and indoor tanning exposure, also have been associated with increased melanoma risk".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against melanoma, researchers examined the effects of Bromelain pharmacological activity on B16F10 murine melanoma cells in vitro.
Compared to other parts of the plant, the highest enzymatic activity that was found in bromelain extracted from the pulp and peels and the optimum bromelain pH among all studied pineapple parts was 6.0 in a temperature above 50 °C in all bromelain extracts.
According to the results from the tested assays, bromelain showed a pharmacological activity against B16F10 melanoma cells by inhibiting 100% of tumor cell proliferation in vitro.
Based on the results, researchers said, "Since bromelain activity was found in different parts of pineapple plants, pineapple residues from the food industry may be used for bromelain extraction".
Furthermore, in melanoma-A375 cells, the application of bromelain exhibited a reduction in proliferation and suppressed their potential for anchorage-independent growth through its anti-inflammatory activity.
Moreover, bromelain was found to inhibit the melanoma-A375 cells by depleting intracellular glutathione and generating reactive oxygen species followed by mitochondrial membrane depolarization.
Bromelain-induced cell-cycle arrest at G(2)/M phase by exhibiting the expression of proteins associated with cell cycle arrest.
Additionally, bromelain increased the expression of proapoptotic and anti-proliferative proteins that cause apoptosis of the tested cell line.
Dr. Bhui K, the lead scientist wrote, "Bromelain afforded substantial anti-cancer potential in these settings; hence we suggest it as a potential prospect for anti-cancer agents besides only an additive in chemotherapy".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of melanoma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells by São Paulo Barretto Miranda ÍK1, Fontes Suzart Miranda A2, Souza FV3, Vannier-Santos MA2, Pirovani CP4, Pepe IM5, Rodowanski IJ5, Ferreira KT4, Mendes Souza Vaz L6, de Assis SA. (PubMed)
(2) Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis by Bhui K1, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y. (PubMed)
(3) More Skin, More Sun, More Tan, More Melanoma by Caroline Chang, MD, Era Caterina Murzaku, BS, Lauren Penn, MD, Naheed R. Abbasi, MD, MPH, Paula D. Davis, MFA, Marianne Berwick, PhD, MPH, and David Polsky, MD, PhD. (PMC)
Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.
The most common sites of melanoma metastasis are the lung and breast.
Most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.
If you are experiencing some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.
Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.
Compared to African Americans, melanoma is more than 20 times more common in whites.
Out of many risk factors associated with the onset of melanoma, some researchers suggested the misunderstanding of the health benefits and adverse effects of sun and tanning exposure may be the leading cause of melanoma.
Dr. Caroline Chang, the lead scientist said, "Despite advances in its detection and treatment, melanoma remains the primary cause of mortality from skin disease in the Western world.".
And, "Several personal risk factors for developing melanoma are well established, including family history, multiple moles, fair skin, blue eyes, red hair, and freckles.3Environmental exposures, chiefly from UV radiation, including outdoor sunburns and indoor tanning exposure, also have been associated with increased melanoma risk".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against melanoma, researchers examined the effects of Bromelain pharmacological activity on B16F10 murine melanoma cells in vitro.
Compared to other parts of the plant, the highest enzymatic activity that was found in bromelain extracted from the pulp and peels and the optimum bromelain pH among all studied pineapple parts was 6.0 in a temperature above 50 °C in all bromelain extracts.
According to the results from the tested assays, bromelain showed a pharmacological activity against B16F10 melanoma cells by inhibiting 100% of tumor cell proliferation in vitro.
Based on the results, researchers said, "Since bromelain activity was found in different parts of pineapple plants, pineapple residues from the food industry may be used for bromelain extraction".
Furthermore, in melanoma-A375 cells, the application of bromelain exhibited a reduction in proliferation and suppressed their potential for anchorage-independent growth through its anti-inflammatory activity.
Moreover, bromelain was found to inhibit the melanoma-A375 cells by depleting intracellular glutathione and generating reactive oxygen species followed by mitochondrial membrane depolarization.
Bromelain-induced cell-cycle arrest at G(2)/M phase by exhibiting the expression of proteins associated with cell cycle arrest.
Additionally, bromelain increased the expression of proapoptotic and anti-proliferative proteins that cause apoptosis of the tested cell line.
Dr. Bhui K, the lead scientist wrote, "Bromelain afforded substantial anti-cancer potential in these settings; hence we suggest it as a potential prospect for anti-cancer agents besides only an additive in chemotherapy".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of melanoma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells by São Paulo Barretto Miranda ÍK1, Fontes Suzart Miranda A2, Souza FV3, Vannier-Santos MA2, Pirovani CP4, Pepe IM5, Rodowanski IJ5, Ferreira KT4, Mendes Souza Vaz L6, de Assis SA. (PubMed)
(2) Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis by Bhui K1, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y. (PubMed)
(3) More Skin, More Sun, More Tan, More Melanoma by Caroline Chang, MD, Era Caterina Murzaku, BS, Lauren Penn, MD, Naheed R. Abbasi, MD, MPH, Paula D. Davis, MFA, Marianne Berwick, PhD, MPH, and David Polsky, MD, PhD. (PMC)
Saturday, February 22, 2020
Herbal Bilberry Protects the Retina Against Degeneration
Retinal degeneration is a condition of retinopathy associated with the gradual loss of neurons near the inner surface of the retina of the eyes.
Most cases of retinopathy are caused by abnormal blood flow.
The most common forms of retinal degeneration are macular degeneration which is a condition when the small central portion of the retina, (the macula) deteriorates and retinitis pigmentosa (RP) which is a rare genetic disorder involved a breakdown and loss of cells in the retina.
Retinal degeneration disease has been found to have a strong impact on daily life, ranging from performing basic functions to personal independence and mental health and vision loss.
According to the statistics, the overall prevalence of age-related macular degeneration (AMD) is in the range of 1.38%-1.55%) and retinitis pigmentosa is 1 in 3,500 to 1 in 4,000 individuals.
Age-related macular degeneration affects more than 1.75 million individuals in the United States, and the number is increasing rapidly due to the growth of an aging population. The number of persons having AMD will increase by 50% to 2.95 million in 2020.
Symptoms of retinal degeneration may include blurred central vision or a blind spot in the center of the visual field.
In severe cases, loss of vision may be possible, particularly in people over the age of 60.
Dr. Rita Ehrlich, the lead scientist said, "Age-related macular degeneration (AMD) is an ocular disease that causes damage to the retinal macula, mostly in the elderly. Normal aging processes can lead to structural and blood flow changes that can predispose patients to AMD".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers in the concern about retinal degenerative diseases induced vision loss and retinal cell death examined the protective effects of the complex lutein formula (CLF) by combining several natural compounds: Calendula officinalis, Lycium barbarum, Vaccinium myrtillus, Cassia obtusifolia, and Rhodiola Rosea.
The formula showed significant protection of retinal functions in an animal model for light-induced retinal degeneration.
Before applying the formula, retinal function in animals exposed to light for 7 days decreased significantly.
However, CLF injection improved the superiority of the retinal function despite light exposure.
Furthermore, CLF restored a greater portion of the outer nuclear layer (ONL) (i.e. the nuclei of photoreceptors) in these animals compared to that of animals that had not received the formula after 7 days of light exposure.
The findings strongly suggested CLF including bilberry exerted a retinal protect against the gradual loss of vision caused by degeneration.
Dr. the lead scientist after taking other factors into account wrote in the final report, "our dietary CLF supplement attenuated retinal function loss resulting from long-term light exposure".
Long term light exposure on animal models has been associated with retinal degeneration, as it damages the retina (phototoxicity) and decreases photoreceptor which has strong implications for age-related macular degeneration.
Taken altogether, bilberry used alone or combined with other herbal remedies may be considered functional remedies for the prevention of retinal degeneration, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of a complex lutein formula in an animal model for light-induced retinal degeneration by Cheng YP1, Ke CY2, Kuo CC1, Lee YJ. (PubMed)
Most cases of retinopathy are caused by abnormal blood flow.
The most common forms of retinal degeneration are macular degeneration which is a condition when the small central portion of the retina, (the macula) deteriorates and retinitis pigmentosa (RP) which is a rare genetic disorder involved a breakdown and loss of cells in the retina.
Retinal degeneration disease has been found to have a strong impact on daily life, ranging from performing basic functions to personal independence and mental health and vision loss.
According to the statistics, the overall prevalence of age-related macular degeneration (AMD) is in the range of 1.38%-1.55%) and retinitis pigmentosa is 1 in 3,500 to 1 in 4,000 individuals.
Age-related macular degeneration affects more than 1.75 million individuals in the United States, and the number is increasing rapidly due to the growth of an aging population. The number of persons having AMD will increase by 50% to 2.95 million in 2020.
Symptoms of retinal degeneration may include blurred central vision or a blind spot in the center of the visual field.
In severe cases, loss of vision may be possible, particularly in people over the age of 60.
Dr. Rita Ehrlich, the lead scientist said, "Age-related macular degeneration (AMD) is an ocular disease that causes damage to the retinal macula, mostly in the elderly. Normal aging processes can lead to structural and blood flow changes that can predispose patients to AMD".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers in the concern about retinal degenerative diseases induced vision loss and retinal cell death examined the protective effects of the complex lutein formula (CLF) by combining several natural compounds: Calendula officinalis, Lycium barbarum, Vaccinium myrtillus, Cassia obtusifolia, and Rhodiola Rosea.
The formula showed significant protection of retinal functions in an animal model for light-induced retinal degeneration.
Before applying the formula, retinal function in animals exposed to light for 7 days decreased significantly.
However, CLF injection improved the superiority of the retinal function despite light exposure.
Furthermore, CLF restored a greater portion of the outer nuclear layer (ONL) (i.e. the nuclei of photoreceptors) in these animals compared to that of animals that had not received the formula after 7 days of light exposure.
The findings strongly suggested CLF including bilberry exerted a retinal protect against the gradual loss of vision caused by degeneration.
Dr. the lead scientist after taking other factors into account wrote in the final report, "our dietary CLF supplement attenuated retinal function loss resulting from long-term light exposure".
Long term light exposure on animal models has been associated with retinal degeneration, as it damages the retina (phototoxicity) and decreases photoreceptor which has strong implications for age-related macular degeneration.
Taken altogether, bilberry used alone or combined with other herbal remedies may be considered functional remedies for the prevention of retinal degeneration, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of a complex lutein formula in an animal model for light-induced retinal degeneration by Cheng YP1, Ke CY2, Kuo CC1, Lee YJ. (PubMed)
Herbal Ashwagandha Protects the Neurons Against the Risk of Neuroblastoma
A neuron is a nerve cell that forms a building block of the nervous system.
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.
Cancer most commonly affects children age 5 or younger compared to less often in older children.
According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.
And 90% of children affected by neuroblastoma are children younger than 5.
Sadly, the the-5-year survival rate of cancer is less than 50%.
The most common symptoms are totally depending on the area that has been effected* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched and changes in bowel habits, such as diarrhea or constipation.
* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain and changes to the eyes, including drooping eyelids and unequal pupil size
Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the protection of neurons, researchers examined the effects of ashwagandha root extract consumption on human neuroblastoma (IMR32).
Human neuroblastoma (IMR32) cells, pretreated with Ashwagandha-reagents for 24 h, were exposed to H2O2 (300 μM) for 2 h, before incubating in control or test medium supplemented with either the alcoholic (i-Extract) or water (WEX) extracts or their active components (withanone or withaferin A), showed a significant effect on H2O2 by 40%.
Furthermore, i-Extract, withanone or WEX also resulted in an increase in neuron viability by 20–30%
In other words, IMR32 cells treated by i-Extract, withanone or WEX protected the neuron integrity and viability against the oxidative activity of H2O2 that causes DNA damage to the brain cells.
On LDH assay analysis, Dr. Navjot Shah, the lead scientist said, " Similar to the viability assay, LDH assay also showed the least protective effect in case of withaferin A-treated cells. Furthermore, cell morphology endorsed that the i-Extract, withanone, and WEX protected IMR32 and C6 cells against H2O2 stress".
Taken altogether, Ashwagandha may be considered a functional herb that protects the neurons against the onset of neuroblastoma, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation by Navjot Shah, 1 Rumani Singh, 1 Upasana Sarangi, 1 Nishant Saxena, 1 Anupama Chaudhary, 1Gurcharan Kaur, 2 Sunil C. Kaul, 1,* and Renu Wadhwa. (PMC)
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.
Cancer most commonly affects children age 5 or younger compared to less often in older children.
According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.
And 90% of children affected by neuroblastoma are children younger than 5.
Sadly, the the-5-year survival rate of cancer is less than 50%.
The most common symptoms are totally depending on the area that has been effected* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched and changes in bowel habits, such as diarrhea or constipation.
* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain and changes to the eyes, including drooping eyelids and unequal pupil size
Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the protection of neurons, researchers examined the effects of ashwagandha root extract consumption on human neuroblastoma (IMR32).
Human neuroblastoma (IMR32) cells, pretreated with Ashwagandha-reagents for 24 h, were exposed to H2O2 (300 μM) for 2 h, before incubating in control or test medium supplemented with either the alcoholic (i-Extract) or water (WEX) extracts or their active components (withanone or withaferin A), showed a significant effect on H2O2 by 40%.
Furthermore, i-Extract, withanone or WEX also resulted in an increase in neuron viability by 20–30%
In other words, IMR32 cells treated by i-Extract, withanone or WEX protected the neuron integrity and viability against the oxidative activity of H2O2 that causes DNA damage to the brain cells.
On LDH assay analysis, Dr. Navjot Shah, the lead scientist said, " Similar to the viability assay, LDH assay also showed the least protective effect in case of withaferin A-treated cells. Furthermore, cell morphology endorsed that the i-Extract, withanone, and WEX protected IMR32 and C6 cells against H2O2 stress".
Taken altogether, Ashwagandha may be considered a functional herb that protects the neurons against the onset of neuroblastoma, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation by Navjot Shah, 1 Rumani Singh, 1 Upasana Sarangi, 1 Nishant Saxena, 1 Anupama Chaudhary, 1Gurcharan Kaur, 2 Sunil C. Kaul, 1,* and Renu Wadhwa. (PMC)
Friday, February 21, 2020
Bromelain Improves the Neurological Status in Post Acute Infarction
Acute brain infarction is the medical condition characterized by the obstruction of the blood supply to the brain, causing the local death of the brain tissue.
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.
The most common symptoms of acute brain infarction are trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm or leg, headache and the trouble with walking.
Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm or leg, trouble with seeing in one or both eyes.
Acute brain infarction is a medical emergency, Prompt treatment can minimize brain damage and potential complications.
There are many factors associated with the risk of acute infarction. However, aging may have a strong and negative implication on acute infarction.
Dr. Mehta RH, the lead scientist wrote, "Older age was associated with a greater proportion of patients with functional limitations, heart failure, prior coronary disease, and renal insufficiency and a lower proportion of male and diabetic patients".
And, "...age-associated differences in clinical characteristics in elderly patients with acute myocardial infarction (AMI), which account for some of the age-associated differences in mortality".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of complications after acute brain infarction, researchers examined the effect of Flogensim on the neurological status on 1st and 7 days after developing the disease.109 patients.
Where Flogenzim consists of highly active proteolytic enzymes containing bromelain, trypsin and of Rutinum.
According to the tested analysis, on day 7, Flogenzim treatment group showed a decrease in the concentration of I1-6, compared to control.
Where high levels of interleukin-6 (I1-6) is associated with postischemic inflammation in patients with acute brain infarction.
Furthermore, on day 21 among patients pertaining to a different group, the considerable difference in consequences were better increases in the treatment group.
More profoundly, the number of patients of Flogenzim group showed no dynamic or even worsening in neurological status decreases, compared to control.
Taken altogether, bromelain used alone or combined with other remedies may be considered a remedy for the improvement of neurological status, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Effect of flogensim in the treatment of postischemic inflammation (according to results of using interleukin-6 in patients with acute brain infarction)].[Article in Ukrainian] by Vinychuk SM, Cheren'ko TM. (PubMed)
(2) Acute myocardial infarction in the elderly: differences by age by Mehta RH1, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. (PubMed)
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.
In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.
The most common symptoms of acute brain infarction are trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm or leg, headache and the trouble with walking.
Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm or leg, trouble with seeing in one or both eyes.
Acute brain infarction is a medical emergency, Prompt treatment can minimize brain damage and potential complications.
There are many factors associated with the risk of acute infarction. However, aging may have a strong and negative implication on acute infarction.
Dr. Mehta RH, the lead scientist wrote, "Older age was associated with a greater proportion of patients with functional limitations, heart failure, prior coronary disease, and renal insufficiency and a lower proportion of male and diabetic patients".
And, "...age-associated differences in clinical characteristics in elderly patients with acute myocardial infarction (AMI), which account for some of the age-associated differences in mortality".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of complications after acute brain infarction, researchers examined the effect of Flogensim on the neurological status on 1st and 7 days after developing the disease.109 patients.
Where Flogenzim consists of highly active proteolytic enzymes containing bromelain, trypsin and of Rutinum.
According to the tested analysis, on day 7, Flogenzim treatment group showed a decrease in the concentration of I1-6, compared to control.
Where high levels of interleukin-6 (I1-6) is associated with postischemic inflammation in patients with acute brain infarction.
Furthermore, on day 21 among patients pertaining to a different group, the considerable difference in consequences were better increases in the treatment group.
More profoundly, the number of patients of Flogenzim group showed no dynamic or even worsening in neurological status decreases, compared to control.
Taken altogether, bromelain used alone or combined with other remedies may be considered a remedy for the improvement of neurological status, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Effect of flogensim in the treatment of postischemic inflammation (according to results of using interleukin-6 in patients with acute brain infarction)].[Article in Ukrainian] by Vinychuk SM, Cheren'ko TM. (PubMed)
(2) Acute myocardial infarction in the elderly: differences by age by Mehta RH1, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. (PubMed)
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