Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.
Several sulfur-containing compounds, isolated from garlic may be very effective in inhibition of platelet aggregation, recent study suggested.
Antiplatelet activity is the effect in decreased platelet aggregation and inhibited thrombus formation.
According to the Ochanomizu University, sulfur-containing compounds in garlic not only inhibited arachidonic acid metabolism but also suppressed aggregation in association with the function of the platelet plasma membrane.
In vitro, garlic mechanisms of action may be comparable to that of the clinically used drug clopidogrel, as the herb exerts antiaggregatory effects. Garlic extracts are acting by inhibition of the ADP pathway, an important physiological agonist of normal hemostasis and thrombosis.
Dr. MacDonald JA lead of researcher said, " The ability of an aromatic disulfide to inhibit platelet aggregation can be enhanced by appending an electron-withdrawing group to the aromatic ring. The results presented establish that the aromatic thiosulfonate is a very effective inhibitor of platelet aggregation"
Besides the sulfur compound, Ajoene, (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide, isolated from alcoholic extracts of garlic reversibly inhibited platelet aggregation through platelet deposition on severely damaged vessel wall but not affected platelet adhesion.
In fact, in the comparsion of the effect of the Garlic Pill with Plavix on Platelet Aggregation and Bleeding Time, groups treated with 1200 or 2400 mg garlic inhibited platelet aggregation substantially, through increased time of bleeding.
The use of garlic supplement should be taken with care for patients who are taking Anticoagulant as garlic may increase risk of bleeding. Also, patients with ulcer should consult with their doctors.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Improving upon the in vitro biological activity of antithrombotic disulfides by MacDonald JA1, Marchand ME, Langler RF.(PubMed)
(2) Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets by Lim H1, Kubota K, Kobayashi A, Seki T, Ariga T.(PubMed)
(3) Antiplatelet activity of Allium ursinum and Allium sativum by Hiyasat B1, Sabha D, Grotzinger K, Kempfert J, Rauwald JW, Mohr FW, Dhein S.(PubMed)
(4) A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental model by Apitz-Castro R1, Badimon JJ, Badimon L.(PubMed)
Wednesday, February 26, 2020
Tuesday, February 25, 2020
Ginger, the Kitchen Spice Which Suppresses the Onset and Progression of Rheumatoid Arthritis
Ginger may have a potential effect on the prevention and treatment of rheumatoid arthritis, some scientists suggested.
Rheumatoid arthritis is a type of arthritis and chronic low-grade inflammatory disease associated with the immune system mistakenly attacks the joint tissue.
According to the statistic, in the US over 1.3 million Americans were affected by rheumatoid arthritis compared to 1% of the worldwide population.
As of today, researchers do not know what triggers the immune system makes antibodies that attack the joint tissue. Why people with the same health condition in the same family, some are susceptible to the onset of the condition while others do not.
However, they do know the increase in age, family history, gender, environment, smoking, and obesity are some prevalent risk factors of RA.
In fact, lifestyle is some preventable risk factor which have been found to elevate the risk RA in the Western world.
Dr.Kathleen Chang, the lead scientist, in the study "Smoking and Rheumatoid Arthritis" clearly suggested that by following a healthy lifestyle, RA may be preventable.
The Doctor team continued " Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation, and epigenetic changes".
And "The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA.
These results indicated a significant change in RA risk just by quitting cigarette smoking.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On seeking alternative therapy for patients with chronic, painful diseases, a research team at the Basic Clin Pharmacol Toxicol investigated the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat rheumatoid arthritis.
Application of Z. officinale extract at the doses higher than 50 mg/kg/day intraperitoneally showed a significant effect in boosting the immune activity in rats with rheumatoid arthritis.
Continued administration for 26 days Z. officinale extract can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.
The results were attributed to the extract effect in inhibiting the production of proinflammatory cytokines which play a critical role in facilitating the onset of low-grade inflammation.
The extract also reduced the immune system in the production of an antibody against the joint tissue.
Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior compared to those of 2 mg/kg/day injection of indomethacin in most of the measured parameters.
Dr. Fouda AM, at the final report, said, "These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis".
In arthritis induced by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw conducted by the King Faisal University, Al-Hufof, researchers examine the anti-rheumatoid arthritis in rats randomly assigned to receive orally and daily (for 28 consecutive days) distilled water as vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight, ginger-turmeric rhizomes mixture ) from the day of arthritis induction.
Application of GTaq (especially the high dose) was more effective (4.2-38.4% higher, P < 0.05-0.001) than those of indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia.
Rats treated the Gtaq also showed a reduction of the impairment of kidney functions and the risks for cardiovascular disease.
Further analysis suggested that the protective effects of GTaq are attributed to increasing the food intake and decreasing the systemic inflammation and antioxidant activity in the inhibition of oxidative stress.
The finding supported the use of ginger-turmeric rhizomes mixture for the treatment against RA severity and complications.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of ginger anti-rheumatoid arthritis possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A1, Jahan R2, Rahmatullah M. (PubMed)
(2) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(3) Smoking and Rheumatoid Arthritis by Kathleen Chang,1 So Min Yang,2 Seong Heon Kim,3 Kyoung Hee Han,4 Se Jin Park,5 andJae Il Shin. (PubMed)
Rheumatoid arthritis is a type of arthritis and chronic low-grade inflammatory disease associated with the immune system mistakenly attacks the joint tissue.
According to the statistic, in the US over 1.3 million Americans were affected by rheumatoid arthritis compared to 1% of the worldwide population.
As of today, researchers do not know what triggers the immune system makes antibodies that attack the joint tissue. Why people with the same health condition in the same family, some are susceptible to the onset of the condition while others do not.
However, they do know the increase in age, family history, gender, environment, smoking, and obesity are some prevalent risk factors of RA.
In fact, lifestyle is some preventable risk factor which have been found to elevate the risk RA in the Western world.
Dr.Kathleen Chang, the lead scientist, in the study "Smoking and Rheumatoid Arthritis" clearly suggested that by following a healthy lifestyle, RA may be preventable.
The Doctor team continued " Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation, and epigenetic changes".
And "The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA.
These results indicated a significant change in RA risk just by quitting cigarette smoking.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On seeking alternative therapy for patients with chronic, painful diseases, a research team at the Basic Clin Pharmacol Toxicol investigated the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat rheumatoid arthritis.
Application of Z. officinale extract at the doses higher than 50 mg/kg/day intraperitoneally showed a significant effect in boosting the immune activity in rats with rheumatoid arthritis.
Continued administration for 26 days Z. officinale extract can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.
The results were attributed to the extract effect in inhibiting the production of proinflammatory cytokines which play a critical role in facilitating the onset of low-grade inflammation.
The extract also reduced the immune system in the production of an antibody against the joint tissue.
Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior compared to those of 2 mg/kg/day injection of indomethacin in most of the measured parameters.
Dr. Fouda AM, at the final report, said, "These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis".
In arthritis induced by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw conducted by the King Faisal University, Al-Hufof, researchers examine the anti-rheumatoid arthritis in rats randomly assigned to receive orally and daily (for 28 consecutive days) distilled water as vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight, ginger-turmeric rhizomes mixture ) from the day of arthritis induction.
Application of GTaq (especially the high dose) was more effective (4.2-38.4% higher, P < 0.05-0.001) than those of indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia.
Rats treated the Gtaq also showed a reduction of the impairment of kidney functions and the risks for cardiovascular disease.
Further analysis suggested that the protective effects of GTaq are attributed to increasing the food intake and decreasing the systemic inflammation and antioxidant activity in the inhibition of oxidative stress.
The finding supported the use of ginger-turmeric rhizomes mixture for the treatment against RA severity and complications.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of ginger anti-rheumatoid arthritis possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A1, Jahan R2, Rahmatullah M. (PubMed)
(2) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(3) Smoking and Rheumatoid Arthritis by Kathleen Chang,1 So Min Yang,2 Seong Heon Kim,3 Kyoung Hee Han,4 Se Jin Park,5 andJae Il Shin. (PubMed)
Bromelain Inhibits the Risk of Skin Cancer In Vitro
Skin cancer is a medical condition caused by irregular cell growth in the skin tissues, due to the alternation of cell DNA.
Most cases of skin cancer in the US are associated with prolong-period of sun exposure. In other words, UV rays that damage the skin have been the main culprit that causes the onset of skin cancer.
Believe it or not, according to the statistics, skin cancer is the most common cancer in the US. one in five Americans will develop skin cancer in their lifetime.
Every day, approximately 9,500 people in the U.S. are diagnosed with skin cancer due to a misunderstanding of the health benefits and risk of sun and tanning exposure.
Most common symptoms at the early stage, are a large brownish spot with darker speckles, a mole that changes in color, size or feel or that bleeds, a small lesion with an irregular border and portions that appear red, pink, white, blue or blue-black.
There are 3 major types of skin cancer, including* Basal cell cancer
It is the most common type of skin cancer associated with the abnormal growth of the cells in the lowest layer of the epidermis. Cancer rarely spread and kill but can cause significant destruction and disfigurement to the affected skin area, accounting for more than 90% of all skin cancer in the U.S.
* Squamous cell cancer
It arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.
* Melanoma
Melanoma is less common compared to other skin cancer caused by the malignancy of melanocytes, the cell produced dark pigment for your skin.
Some researchers suggested that by seeking the shade, especially between 10 AM and 4 PM. covering yourself with proper sunglasses, clothing, and hat, using sun protective cream, particularly in avoidance of tanning and UV tanning beds, most types of skin cancer are preventable
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to find a natural ingredient for the treatment of skin cancer, researchers examined the bromelain (BL) effect in the form of nanoparticles (NPs) based delivery systems on skin cancer cells.
The formulated NPs with a mean particle size of 130.4 ± 8.81 nm exhibited sustained release of BL by observation of the analysis.
According to the tested assays, BL loaded poly (lactic-co-glycolic acid) NPs enhanced anti-tumor effects compared to free BL.
In tumorigenesis mice model, NPs reduced the average number of tumors by 2.3 folds), delayed tumorigenesis by 2 weeks), and inhibited the percent tumorigenesis by 4 folds.
Furthermore, the administration of NPs also exerted a significant effect on reduced the percent mortality rate and the average tumor volume.
More precisely, NPs demonstrated anti-cancer cell efficacy was attributed to its capability in modulating the expression of pro-apoptotic (P53, Bax) and anti-apoptotic (Bcl2) proteins.
Based on the finding, researchers said, "developed NPs formulation could be used to improve the efficacy of chemotherapy by exerting chemo-preventive effects against induced carcinogenesis at lower dosages".
Additionally, in another mouse skin tumorigenesis model, bromelain not only exerted a similar effect of the aforementioned study it also reduced tumor volume up to a tune of approximately 65%.
In this case, bromelain induced cancer cells apoptosis by stimulating the expression of proteins associated with tumor-suppressive and pro-apoptotic genes, inhibiting the gene involved in anti-apoptosis.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of skin cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model by Bhatnagar P1, Pant AB2, Shukla Y2, Chaudhari B2, Kumar P1, Gupta KC. (PubMed)
(2) Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway by Bhui K1, Prasad S, George J, Shukla Y. (PubMed)
Most cases of skin cancer in the US are associated with prolong-period of sun exposure. In other words, UV rays that damage the skin have been the main culprit that causes the onset of skin cancer.
Believe it or not, according to the statistics, skin cancer is the most common cancer in the US. one in five Americans will develop skin cancer in their lifetime.
Every day, approximately 9,500 people in the U.S. are diagnosed with skin cancer due to a misunderstanding of the health benefits and risk of sun and tanning exposure.
Most common symptoms at the early stage, are a large brownish spot with darker speckles, a mole that changes in color, size or feel or that bleeds, a small lesion with an irregular border and portions that appear red, pink, white, blue or blue-black.
There are 3 major types of skin cancer, including* Basal cell cancer
It is the most common type of skin cancer associated with the abnormal growth of the cells in the lowest layer of the epidermis. Cancer rarely spread and kill but can cause significant destruction and disfigurement to the affected skin area, accounting for more than 90% of all skin cancer in the U.S.
* Squamous cell cancer
It arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.
* Melanoma
Melanoma is less common compared to other skin cancer caused by the malignancy of melanocytes, the cell produced dark pigment for your skin.
Some researchers suggested that by seeking the shade, especially between 10 AM and 4 PM. covering yourself with proper sunglasses, clothing, and hat, using sun protective cream, particularly in avoidance of tanning and UV tanning beds, most types of skin cancer are preventable
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to find a natural ingredient for the treatment of skin cancer, researchers examined the bromelain (BL) effect in the form of nanoparticles (NPs) based delivery systems on skin cancer cells.
The formulated NPs with a mean particle size of 130.4 ± 8.81 nm exhibited sustained release of BL by observation of the analysis.
According to the tested assays, BL loaded poly (lactic-co-glycolic acid) NPs enhanced anti-tumor effects compared to free BL.
In tumorigenesis mice model, NPs reduced the average number of tumors by 2.3 folds), delayed tumorigenesis by 2 weeks), and inhibited the percent tumorigenesis by 4 folds.
Furthermore, the administration of NPs also exerted a significant effect on reduced the percent mortality rate and the average tumor volume.
More precisely, NPs demonstrated anti-cancer cell efficacy was attributed to its capability in modulating the expression of pro-apoptotic (P53, Bax) and anti-apoptotic (Bcl2) proteins.
Based on the finding, researchers said, "developed NPs formulation could be used to improve the efficacy of chemotherapy by exerting chemo-preventive effects against induced carcinogenesis at lower dosages".
Additionally, in another mouse skin tumorigenesis model, bromelain not only exerted a similar effect of the aforementioned study it also reduced tumor volume up to a tune of approximately 65%.
In this case, bromelain induced cancer cells apoptosis by stimulating the expression of proteins associated with tumor-suppressive and pro-apoptotic genes, inhibiting the gene involved in anti-apoptosis.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of skin cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model by Bhatnagar P1, Pant AB2, Shukla Y2, Chaudhari B2, Kumar P1, Gupta KC. (PubMed)
(2) Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway by Bhui K1, Prasad S, George J, Shukla Y. (PubMed)
Monday, February 24, 2020
Herbal Butterbur, Exhibits Cytotoxic Effects Against Cancers Cells
Scientists may have found a medicinal remedy for the prevention and treatment of cancer with no side effects, according to studies.
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable ways in our body, due to the change of cellular DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ. At the 0 stage, due to the very small size of the tumor, most patients so not experience any symptoms.
However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.
Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Symptoms of cancer at this stage are totally dependent on the affected area, including vomiting blood in oral and lung cancer blood in the urine in bladder cancer. hoarseness in throat cancer. ... Persistent lumps in the breast and lymph cancer and indigestion or difficulty swallowing in digestive related cancers.
Researchers do not know the exact causes of cancers, but they do know, according to epidemiological studies that age, alcohol cancer, chronic Inflammation, genetic proposition, unhealthy diet, change of hormones use of immunosuppression, infectious agents, obesity, exposure to radiation and sunlight, use of tobacco are most common risk factors associated with the onset of some specific cancers.
Some researchers in the investigation of weakened immune function in the risk of cancer suggested people with a weakened immune system lost the function
1) to stimulate the T cells inactivation of the B cells in the production of p53, a tumor suppressor gene, or antioncogene that inhibits the cancer cell proliferation and tumor development and
2) to stimulate the production of pro-inflammatory cytokines to kill off the DNA alternated damage cells in the acute phase of inflammation.
In other words, if you have a strong immune system, your risk of cancer is substantially lower compared to the general public.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere. the herbal plant has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The Shandong University at Weihai, on finding a natural compound for the treatment of cancer with no side effects examined a new bakkenolide isolated from Butterbur anti-cancer effects.
The new bakkenolide exerted a potent cytotoxic activity against a number of cultured human cancer cells, including human cervical carcinoma (HeLa), human breast cancer (MCF-7) and murine Lewis lung carcinoma (LLC) cell lines.
According to the National Veterinary Research and Quarantine Service in vitro methanol extract from the leaves in the rat liver epithelial cells. significantly decreased spontaneous beta-galactosidase activity and beta-galactosidase activity induced by a mutagen.
Elevated beta-galactosidase (beta-gal) enzyme activity is an indication of the tumor and metastatic expression.
All doses of the extract (0.08-100 mg/plate) decreased the reversion frequency induced by benzo (alpha)pyrene (BaP) in S. Typhimurium TA 98 of the Salmonella typhimurium.
Additional analysis of the experiment, PJ extract showed greater cytotoxic effects on the human stomach, colon, and uterus cancer cells than on other cancer cell types and normal rat liver epithelial cells.
Furthermore, PJ significantly increased the numbers of gap junction proteins associated with tumor suppression in a dose-dependent manner.
Dr. the lead scientist said, "Based on these findings, PJ is suggested to contain antimutagenic and anticarcinogenic compounds".
Taken altogether, herbal Butterbur may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of cancers.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bakkenolides from Petasites tatewakianus by Dong XW, Li RJ, Gao X, Row KH.(PubMed)
(2) Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves by Kang HG, Jeong SH, Cho JH.(PubMed)
(3) Interactions between the tumor suppressor p53 and immune responses by Menendez D1, Shatz M, Resnick MA. (PubMed)
Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable ways in our body, due to the change of cellular DNA.
Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ. At the 0 stage, due to the very small size of the tumor, most patients so not experience any symptoms.
However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.
Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Symptoms of cancer at this stage are totally dependent on the affected area, including vomiting blood in oral and lung cancer blood in the urine in bladder cancer. hoarseness in throat cancer. ... Persistent lumps in the breast and lymph cancer and indigestion or difficulty swallowing in digestive related cancers.
Researchers do not know the exact causes of cancers, but they do know, according to epidemiological studies that age, alcohol cancer, chronic Inflammation, genetic proposition, unhealthy diet, change of hormones use of immunosuppression, infectious agents, obesity, exposure to radiation and sunlight, use of tobacco are most common risk factors associated with the onset of some specific cancers.
Some researchers in the investigation of weakened immune function in the risk of cancer suggested people with a weakened immune system lost the function
1) to stimulate the T cells inactivation of the B cells in the production of p53, a tumor suppressor gene, or antioncogene that inhibits the cancer cell proliferation and tumor development and
2) to stimulate the production of pro-inflammatory cytokines to kill off the DNA alternated damage cells in the acute phase of inflammation.
In other words, if you have a strong immune system, your risk of cancer is substantially lower compared to the general public.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere. the herbal plant has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The Shandong University at Weihai, on finding a natural compound for the treatment of cancer with no side effects examined a new bakkenolide isolated from Butterbur anti-cancer effects.
The new bakkenolide exerted a potent cytotoxic activity against a number of cultured human cancer cells, including human cervical carcinoma (HeLa), human breast cancer (MCF-7) and murine Lewis lung carcinoma (LLC) cell lines.
According to the National Veterinary Research and Quarantine Service in vitro methanol extract from the leaves in the rat liver epithelial cells. significantly decreased spontaneous beta-galactosidase activity and beta-galactosidase activity induced by a mutagen.
Elevated beta-galactosidase (beta-gal) enzyme activity is an indication of the tumor and metastatic expression.
All doses of the extract (0.08-100 mg/plate) decreased the reversion frequency induced by benzo (alpha)pyrene (BaP) in S. Typhimurium TA 98 of the Salmonella typhimurium.
Additional analysis of the experiment, PJ extract showed greater cytotoxic effects on the human stomach, colon, and uterus cancer cells than on other cancer cell types and normal rat liver epithelial cells.
Furthermore, PJ significantly increased the numbers of gap junction proteins associated with tumor suppression in a dose-dependent manner.
Dr. the lead scientist said, "Based on these findings, PJ is suggested to contain antimutagenic and anticarcinogenic compounds".
Taken altogether, herbal Butterbur may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of cancers.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bakkenolides from Petasites tatewakianus by Dong XW, Li RJ, Gao X, Row KH.(PubMed)
(2) Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves by Kang HG, Jeong SH, Cho JH.(PubMed)
(3) Interactions between the tumor suppressor p53 and immune responses by Menendez D1, Shatz M, Resnick MA. (PubMed)
Herbal Bilberry, the Anti-Obesity Functional Food in Animal and Human Study
On seeking natural therapy with no side effects, scientists may have a herbal remedy that visceral fat accumulation in obesity, according to studies.
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.
Obesity is a medical condition caused by excess body fat accumulated to an extent that impact personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.
Obesity rates have increased for all population groups in the US over the last several decades, coincidently with the periods in the promotion of the Western diet.
Dr. Maximilian Tremmel, the lead scientist in the investigation of economic burden in obesity wrote, "The rising prevalence of obesity represents an important public health issue. An assessment of its costs may be useful in providing recommendations for policy and decision-makers" and "there was great variety in the included obesity-related diseases and complications among the studies".
And, "There is an urgent need for public health measures to prevent obesity in order to save societal resources. Moreover, international consensus is required on standardized methods to calculate the cost of obesity to improve homogeneity and comparability".
The findings strongly suggested that widespread obesity has caused significant pressure in the public health care system and an impact in the financial and economic burden.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural remedy for the treatment of obesity, researchers examined the effects of anthocyanin-rich phytochemicals found in aronia fruits (aronia phytochemicals) and bilberry in high-fat-diet-induced dietary obese rats.
During the study, bilberry phytochemicals-supplemented rats showed a significant reduction of total visceral fat mass but to a lesser extent compared to aronia phytochemicals.
Similarly, perirenal and epididymal adipose tissue mass in rats fed aronia phytochemicals was by far greater than the bilberry phytochemicals group.
Bilberry lowered the mesenteric adipose tissue mass.
Bilberry also exerted the equivalently inhibited the increases in plasma triglyceride levels, compared to that of aronia phytochemicals with a half-maximal inhibitory concentration (IC(50)) of 1.50 mg/mL.
The results suggest that anthocyanin-rich phytochemicals in aronia fruits and bilberry may have a potency for the treatment of obesity through suppressing the visceral fat accumulation and hyperglycemia.
In order to reveal more information about bilberry anti-obesity property, researchers evaluated a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults.
Participants (N = 103, 18-65 y, BMI ≥ 25 kg/m2) included in the study were randomized to flavonoid (F) or placebo (P) groups for 12 weeks with blood and 24 h urine samples collected prestudy and after 4 and 12 weeks in a parallel design.
The supplement included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega 3 fatty acids.
According to the urinary assay, the 4 weeks, urine total phenolics increased 24% in F versus P with similar changes at 12 weeks.
In of F demonstrated the shifts in 63 biochemicals compared to P with 70% from the lipid and xenobiotics super-pathways, according to the examination of metabolomics assay.
Where metabolite profile is reflective of metabolic processes, including pathophysiological changes characteristic of obesity-related complications.
The findings suggested that flavonoid-rich supplements may have a strong effect on the change of metabolome which is the sum of all the small-molecule chemicals found in a biological sample, often the blood plasma and considered a measurement of obesity and health beyond BMI.
Taken altogether, bilberry used alone or combined with other agents may be considered functional remedies for the prevention and treatment of obesity, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats by Takahashi A1, Shimizu H, Okazaki Y, Sakaguchi H, Taira T, Suzuki T, Chiji H. (PubMed)
(2) Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women by Nieman DC1, Ramamoorthy S2, Kay CD3, Goodman CL1, Capps CR1, Shue ZL1, Heyl N1, Grace MH3, Lila MA. (PubMed)
(3) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.
Obesity is a medical condition caused by excess body fat accumulated to an extent that impact personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.
Obesity rates have increased for all population groups in the US over the last several decades, coincidently with the periods in the promotion of the Western diet.
Dr. Maximilian Tremmel, the lead scientist in the investigation of economic burden in obesity wrote, "The rising prevalence of obesity represents an important public health issue. An assessment of its costs may be useful in providing recommendations for policy and decision-makers" and "there was great variety in the included obesity-related diseases and complications among the studies".
And, "There is an urgent need for public health measures to prevent obesity in order to save societal resources. Moreover, international consensus is required on standardized methods to calculate the cost of obesity to improve homogeneity and comparability".
The findings strongly suggested that widespread obesity has caused significant pressure in the public health care system and an impact in the financial and economic burden.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural remedy for the treatment of obesity, researchers examined the effects of anthocyanin-rich phytochemicals found in aronia fruits (aronia phytochemicals) and bilberry in high-fat-diet-induced dietary obese rats.
During the study, bilberry phytochemicals-supplemented rats showed a significant reduction of total visceral fat mass but to a lesser extent compared to aronia phytochemicals.
Similarly, perirenal and epididymal adipose tissue mass in rats fed aronia phytochemicals was by far greater than the bilberry phytochemicals group.
Bilberry lowered the mesenteric adipose tissue mass.
Bilberry also exerted the equivalently inhibited the increases in plasma triglyceride levels, compared to that of aronia phytochemicals with a half-maximal inhibitory concentration (IC(50)) of 1.50 mg/mL.
The results suggest that anthocyanin-rich phytochemicals in aronia fruits and bilberry may have a potency for the treatment of obesity through suppressing the visceral fat accumulation and hyperglycemia.
In order to reveal more information about bilberry anti-obesity property, researchers evaluated a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults.
Participants (N = 103, 18-65 y, BMI ≥ 25 kg/m2) included in the study were randomized to flavonoid (F) or placebo (P) groups for 12 weeks with blood and 24 h urine samples collected prestudy and after 4 and 12 weeks in a parallel design.
The supplement included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega 3 fatty acids.
According to the urinary assay, the 4 weeks, urine total phenolics increased 24% in F versus P with similar changes at 12 weeks.
In of F demonstrated the shifts in 63 biochemicals compared to P with 70% from the lipid and xenobiotics super-pathways, according to the examination of metabolomics assay.
Where metabolite profile is reflective of metabolic processes, including pathophysiological changes characteristic of obesity-related complications.
The findings suggested that flavonoid-rich supplements may have a strong effect on the change of metabolome which is the sum of all the small-molecule chemicals found in a biological sample, often the blood plasma and considered a measurement of obesity and health beyond BMI.
Taken altogether, bilberry used alone or combined with other agents may be considered functional remedies for the prevention and treatment of obesity, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats by Takahashi A1, Shimizu H, Okazaki Y, Sakaguchi H, Taira T, Suzuki T, Chiji H. (PubMed)
(2) Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women by Nieman DC1, Ramamoorthy S2, Kay CD3, Goodman CL1, Capps CR1, Shue ZL1, Heyl N1, Grace MH3, Lila MA. (PubMed)
(3) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)
Sunday, February 23, 2020
Healthy Food Cranberry Protects the Heart Against Cardiovascular Toxicity
Cardiac toxicity is a condition in which the heart has been damage to some extents caused by harmful chemicals, including toxins induced by the treatment of chemotherapy, leading to reduced heart muscles function to pump blood and heart failure.
Long term intake of certain medication and people who are under treatment of chemotherapy have been found in most cases of cardiotoxicity.
Dr. Polonsky TS, the lead scientist wrote, "Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy".
And, "Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity".
Additionally, human immunodeficiency virus (HIV) infection, genetic preposition, a malignant disease associated with the amyloid deposited on the heart or other organs, high blood pressure, untreated hyperthyroidism, and vitamin b2 deficiency are some of the most prevalent factors found in patients with cardiotoxicity.
Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes
* Cardiomyopathy is a disorder caused a weaken or damage of heart muscle, affecting the heart rhythm or inducing the risk of heart failure.
* Myocarditis is a condition of inflammation of the heart, that can lead to changes in heart rhythm or heart failure.
* Pericarditis is a condition caused by the inflammation of the sac surrounding the heart, inducing chest pain or heart failure.
* Acute coronary syndromes that affect the blood flow due to blood vessel damage.
* Congestive heart failure is a result that affects the function of the heart in pumping blood throughout the body.
Most common symptoms of cardiotoxicity are associated with not enough blood circulation in the body such as tiredness and fatigue, a long-term (chronic) cough, shortness of breath, floating due to the enlarged heart muscle, abnormal heart or lung sounds and swelling in your hands, feet, or unusual weight gain.
Conventionally, treatment of cardiotoxicity is totally depending on the types of the disease including
Beta-blockers, ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow and diuretics.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cardiovascular diseases, researchers examined the protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in an animal model.
According to the results of rats were given CRAN orally (100mg/kg/day for 10 consecutive days) and DOX (15mg/kg; i.p.) for 7 days, CRAN protected the heart function against DOX-induced increased mortality and ECG changes.
The reduced levels of antioxidants enzymes and increased oxidative stress in the cardiac tissues induced by DOX such as glutathione (GSH) depletion and oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls were significantly inhibited by the administration of CRAN.
Furthermore, the reduced cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) induced by DOX were also inhibited by CRAN.
Moreover, CRAN also improved the cardiac myeloperoxidase (MPO) activity against infection compared to untreated rats.
Most important, CRAN also normalized the levels of enzymes associated with cardio muscle damage and injury casued by DOX such as troponin I, creatine phosphokinase (CK), and creatine kinase-MB.
Based on the findings, researchers said, "CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats".
Taken altogether, cranberry may be considered a remedy for the protection of cardiovascular toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats by Elberry AA1, Abdel-Naim AB, Abdel-Sattar EA, Nagy AA, Mosli HA, Mohamadin AM, Ashour O.M. (PubMed)
(2) Risk factors for chemotherapy-related cardiac toxicity by Polonsky TS1, DeCara JM. (PubMed)
Long term intake of certain medication and people who are under treatment of chemotherapy have been found in most cases of cardiotoxicity.
Dr. Polonsky TS, the lead scientist wrote, "Age and preexisting left ventricular dysfunction have been identified most consistently as being associated with the development of clinical heart failure or a worsening of left ventricular function with chemotherapy".
And, "Other cardiovascular conditions, including hypertension, diabetes, and coronary artery disease, are also associated with the risk of cardiotoxicity".
Additionally, human immunodeficiency virus (HIV) infection, genetic preposition, a malignant disease associated with the amyloid deposited on the heart or other organs, high blood pressure, untreated hyperthyroidism, and vitamin b2 deficiency are some of the most prevalent factors found in patients with cardiotoxicity.
Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes
* Cardiomyopathy is a disorder caused a weaken or damage of heart muscle, affecting the heart rhythm or inducing the risk of heart failure.
* Myocarditis is a condition of inflammation of the heart, that can lead to changes in heart rhythm or heart failure.
* Pericarditis is a condition caused by the inflammation of the sac surrounding the heart, inducing chest pain or heart failure.
* Acute coronary syndromes that affect the blood flow due to blood vessel damage.
* Congestive heart failure is a result that affects the function of the heart in pumping blood throughout the body.
Most common symptoms of cardiotoxicity are associated with not enough blood circulation in the body such as tiredness and fatigue, a long-term (chronic) cough, shortness of breath, floating due to the enlarged heart muscle, abnormal heart or lung sounds and swelling in your hands, feet, or unusual weight gain.
Conventionally, treatment of cardiotoxicity is totally depending on the types of the disease including
Beta-blockers, ACE inhibitors induce (widen) the arterial dilation and improvement of the blood flow and diuretics.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cardiovascular diseases, researchers examined the protective effect of cranberry extract (CRAN) against DOX-induced cardiotoxicity in an animal model.
According to the results of rats were given CRAN orally (100mg/kg/day for 10 consecutive days) and DOX (15mg/kg; i.p.) for 7 days, CRAN protected the heart function against DOX-induced increased mortality and ECG changes.
The reduced levels of antioxidants enzymes and increased oxidative stress in the cardiac tissues induced by DOX such as glutathione (GSH) depletion and oxidized glutathione (GSSG), malondialdehyde (MDA), and protein carbonyls were significantly inhibited by the administration of CRAN.
Furthermore, the reduced cardiac activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) induced by DOX were also inhibited by CRAN.
Moreover, CRAN also improved the cardiac myeloperoxidase (MPO) activity against infection compared to untreated rats.
Most important, CRAN also normalized the levels of enzymes associated with cardio muscle damage and injury casued by DOX such as troponin I, creatine phosphokinase (CK), and creatine kinase-MB.
Based on the findings, researchers said, "CRAN alleviated histopathological changes in rats' hearts treated with DOX. In conclusion, CRAN protects against DOX-induced cardiotoxicity in rats".
Taken altogether, cranberry may be considered a remedy for the protection of cardiovascular toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats by Elberry AA1, Abdel-Naim AB, Abdel-Sattar EA, Nagy AA, Mosli HA, Mohamadin AM, Ashour O.M. (PubMed)
(2) Risk factors for chemotherapy-related cardiac toxicity by Polonsky TS1, DeCara JM. (PubMed)
Bromelain, Inhibits Melanoma in Vitro and Vivo
Melanoma is a type of skin cancer caused by the alternation of DNA of the cells from the pigment-containing cells known as melanocytes.
Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.
The most common sites of melanoma metastasis are the lung and breast.
Most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.
If you are experiencing some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.
Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.
Compared to African Americans, melanoma is more than 20 times more common in whites.
Out of many risk factors associated with the onset of melanoma, some researchers suggested the misunderstanding of the health benefits and adverse effects of sun and tanning exposure may be the leading cause of melanoma.
Dr. Caroline Chang, the lead scientist said, "Despite advances in its detection and treatment, melanoma remains the primary cause of mortality from skin disease in the Western world.".
And, "Several personal risk factors for developing melanoma are well established, including family history, multiple moles, fair skin, blue eyes, red hair, and freckles.3Environmental exposures, chiefly from UV radiation, including outdoor sunburns and indoor tanning exposure, also have been associated with increased melanoma risk".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against melanoma, researchers examined the effects of Bromelain pharmacological activity on B16F10 murine melanoma cells in vitro.
Compared to other parts of the plant, the highest enzymatic activity that was found in bromelain extracted from the pulp and peels and the optimum bromelain pH among all studied pineapple parts was 6.0 in a temperature above 50 °C in all bromelain extracts.
According to the results from the tested assays, bromelain showed a pharmacological activity against B16F10 melanoma cells by inhibiting 100% of tumor cell proliferation in vitro.
Based on the results, researchers said, "Since bromelain activity was found in different parts of pineapple plants, pineapple residues from the food industry may be used for bromelain extraction".
Furthermore, in melanoma-A375 cells, the application of bromelain exhibited a reduction in proliferation and suppressed their potential for anchorage-independent growth through its anti-inflammatory activity.
Moreover, bromelain was found to inhibit the melanoma-A375 cells by depleting intracellular glutathione and generating reactive oxygen species followed by mitochondrial membrane depolarization.
Bromelain-induced cell-cycle arrest at G(2)/M phase by exhibiting the expression of proteins associated with cell cycle arrest.
Additionally, bromelain increased the expression of proapoptotic and anti-proliferative proteins that cause apoptosis of the tested cell line.
Dr. Bhui K, the lead scientist wrote, "Bromelain afforded substantial anti-cancer potential in these settings; hence we suggest it as a potential prospect for anti-cancer agents besides only an additive in chemotherapy".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of melanoma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells by São Paulo Barretto Miranda ÍK1, Fontes Suzart Miranda A2, Souza FV3, Vannier-Santos MA2, Pirovani CP4, Pepe IM5, Rodowanski IJ5, Ferreira KT4, Mendes Souza Vaz L6, de Assis SA. (PubMed)
(2) Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis by Bhui K1, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y. (PubMed)
(3) More Skin, More Sun, More Tan, More Melanoma by Caroline Chang, MD, Era Caterina Murzaku, BS, Lauren Penn, MD, Naheed R. Abbasi, MD, MPH, Paula D. Davis, MFA, Marianne Berwick, PhD, MPH, and David Polsky, MD, PhD. (PMC)
Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.
The most common sites of melanoma metastasis are the lung and breast.
Most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.
If you are experiencing some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.
Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.
Compared to African Americans, melanoma is more than 20 times more common in whites.
Out of many risk factors associated with the onset of melanoma, some researchers suggested the misunderstanding of the health benefits and adverse effects of sun and tanning exposure may be the leading cause of melanoma.
Dr. Caroline Chang, the lead scientist said, "Despite advances in its detection and treatment, melanoma remains the primary cause of mortality from skin disease in the Western world.".
And, "Several personal risk factors for developing melanoma are well established, including family history, multiple moles, fair skin, blue eyes, red hair, and freckles.3Environmental exposures, chiefly from UV radiation, including outdoor sunburns and indoor tanning exposure, also have been associated with increased melanoma risk".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against melanoma, researchers examined the effects of Bromelain pharmacological activity on B16F10 murine melanoma cells in vitro.
Compared to other parts of the plant, the highest enzymatic activity that was found in bromelain extracted from the pulp and peels and the optimum bromelain pH among all studied pineapple parts was 6.0 in a temperature above 50 °C in all bromelain extracts.
According to the results from the tested assays, bromelain showed a pharmacological activity against B16F10 melanoma cells by inhibiting 100% of tumor cell proliferation in vitro.
Based on the results, researchers said, "Since bromelain activity was found in different parts of pineapple plants, pineapple residues from the food industry may be used for bromelain extraction".
Furthermore, in melanoma-A375 cells, the application of bromelain exhibited a reduction in proliferation and suppressed their potential for anchorage-independent growth through its anti-inflammatory activity.
Moreover, bromelain was found to inhibit the melanoma-A375 cells by depleting intracellular glutathione and generating reactive oxygen species followed by mitochondrial membrane depolarization.
Bromelain-induced cell-cycle arrest at G(2)/M phase by exhibiting the expression of proteins associated with cell cycle arrest.
Additionally, bromelain increased the expression of proapoptotic and anti-proliferative proteins that cause apoptosis of the tested cell line.
Dr. Bhui K, the lead scientist wrote, "Bromelain afforded substantial anti-cancer potential in these settings; hence we suggest it as a potential prospect for anti-cancer agents besides only an additive in chemotherapy".
Taken altogether, bromelain may be considered supplements for the prevention and treatment of melanoma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells by São Paulo Barretto Miranda ÍK1, Fontes Suzart Miranda A2, Souza FV3, Vannier-Santos MA2, Pirovani CP4, Pepe IM5, Rodowanski IJ5, Ferreira KT4, Mendes Souza Vaz L6, de Assis SA. (PubMed)
(2) Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis by Bhui K1, Tyagi S, Srivastava AK, Singh M, Roy P, Singh R, Shukla Y. (PubMed)
(3) More Skin, More Sun, More Tan, More Melanoma by Caroline Chang, MD, Era Caterina Murzaku, BS, Lauren Penn, MD, Naheed R. Abbasi, MD, MPH, Paula D. Davis, MFA, Marianne Berwick, PhD, MPH, and David Polsky, MD, PhD. (PMC)
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