Monday, March 9, 2020

Herbal Comfrey(Symphytum officinale L.), a Natural Treatment for Unilateral Ankle Sprains

Ankle sprains are the most common injury in the sport associated with overstretching of fibers or of the collagen of the ankle ligaments, causing the partial or complete disruption of the fibers.

In athletes with acute lateral ankle sprains, the balance ability in patients with acute lateral ankle sprain was significantly weaker. The weight-bearing on the nondominant limb was found to be significantly higher than on the dominant limb.

Treatment is totally depending on the severity of the condition, including
* Rest by avoiding activities that cause pain, swelling or discomfort.

* Ice treatment with an ice pack or ice slush bath immediately for 15 to 20 minutes and repeat every two to three to relieve pain and swelling.

* Compression is effective to stop swelling.

* Elevation

By keeping your foot elevated has been found to decrease pain and swelling.

And

* Medications
Over-the-counter pain relievers — such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve, others) or acetaminophen (Tylenol, others) have been used to manage the pain of a sprained ankle.

* Surgery
In some cases, surgery may be necessary if the repair a ligament that won't heal or won't heal properly, or the reconstruction of ligament tissues.

Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.

On finding a potential compound for the treatment of diseases associated with ankle pain, researchers compared the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains.

The observer-blind, randomized, multi-center clinical trial with two independent treatment groups "comfrey extract" and "diclofenac gel" (parallel-group design) included a total of 164 patients (82 in the comfrey group and 82 in the diclofenac group, intention-to-treat (ITT) analysis) was conducted by the Istituto Ortopedico Galeazzi.

According to the results of the tested assay, the area under the curve (AUC) of the difference of the tenderness values contra-lateral minus injured side, pain at rest and on movement, and swelling and ankle movement were significantly improved in the comfrey group, compared to the diclofenac group.

Furthermore, on average of mean difference comfrey extract minus diclofenac, the AUC was +61.1 h x N/cm2 greater for patients treated with comfrey extract compared to diclofenac group (95% confidence interval: 19.08; 103.09 h x N/cm2).

The difference between the two treatment groups was statistically significant (analysis of variance with factors "study drug", "center", and "drug x center interaction") as the comfrey group showed a far better result in the treatment of unilateral ankle sprains.

There were no side effects during the treatment periods in both groups.

Based on the findings, researchers said, " The re-evaluation of the data showed the superiority of the plant-based ointment over the diclofenac gel in the treatment of distortions".

Taken altogether, Comfrey plant-based ointment combined with other herbal medicine may be considered a remedy for the treatment of unilateral ankle sprains, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions) by D'Anchise R1, Bulitta M, Giannetti B. (PubMed)

Sunday, March 8, 2020

Dandelion (Taraxacum officinale), Inhibits the Breast Cancer Cells in Vitro

The breast is the tissue overlying the chest muscles. in women, breasts are made of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of the women's breasts is totally determined by the amount of fat.

Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

Early-stage of breast cancer in most cases first noticed as a painless lump in the breast or armpit and most often is discovered by patients or patients partner or their doctors during a routine physical exam.

The early stage of breast cancer symptoms normally include
* Lump (mass) in the breast

* Lump in the armpit (lymph nodes)

* Nipple discharge (clear or bloody)

* Inverted or retracted nipple

* Scaly or pitted skin on nipple persistent tenderness of the breast

and Unusual breast pain or discomfort

At the advanced stage, breast cancer can travel a distance away to infect other healthy organs and tissues and induce symptoms of
* Bone pain (Secondary tumors in the bone)

* Shortness of breath (Secondary tumors in the lung)

* Unintentional weight loss and drop in appetite (Secondary tumors in the liver)

* Headaches, neurological pain or weakness (Secondary tumors in the nervous system)

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of cancer, scientists compared the anti-breast cancer effects of three aqueous extracts prepared from the mature leaves, flowers, and roots of Taraxacum officinale.

According to the tested differentiation
* The crude extract of the dandelion leaf (DLE) showed strong activity against the growth of MCF-7/AZ breast cancer cells associated with the signaling on the surface of the cell to the DNA in the nucleus of the cell in an ERK-dependent manner.

* The aqueous extracts of dandelion flower (DFE) and root (DRE) showed no effect on the growth of either cell line, however, DRE blocked the invasion of MCF-7/AZ breast cancer cells by decreasing phosphorylation levels of FAK and SRC involved in cancer cell adhesion.

* Additionally, breast cancer cell migration associated with matrix metalloproteinases also reduced by the injection DRE.

Based on the findings, researchers suggested, "This study provides new scientific data on TO and suggests that TO extracts or individual components present in the extracts may be of value as novel anti-cancer agents".

Taken altogether, Dandelion leaves and roots may be considered remedies for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells by Sigstedt SC1, Hooten CJ, Callewaert MC, Jenkins AR, Romero AE, Pullin MJ, Kornienko A, Lowrey TK, Slambrouck SV, Steelant WF. (PubMed)

Herbal Cascara Sagrada (Rhamnus purshiana), the Potent Anti-Prostate Cancer Functional Herb, Researcher Suggested

Scientists may have found a herbal medicine for the prevention and treatment of prostate cancer with no side effects, according to the studies.

Prostate cancer is a condition characterized by abnormal cell growth in prostate tissue.

Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow-growing. Enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Contrary to popular belief, as of today, prostate cancer no longer is a disease of aging male, it has a tendency to affect the younger age population, particularly to that of age group 20 -40.

According to the statistic, most men diagnosed with prostate cancer survival or died due to another disease instead of prostate cancer. In the US, approximately 2.9 million men who have been diagnosed with prostate cancer at some point are still alive today.

Also, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and the disease is the most common cancer in American men.


Researchers do not know the exact causes of prostate cancer. Epidemiological studies suggested age, family history, being obese or obese, genetic preposition, particularly a poor diet with high saturated and trans fat, red meat and processed food, and low fruits and vegetables and whole-grain are associated with the onset of prostate cancer.

Some researchers suggested ethnicity is a predictor involved in the development of the disease due to a number of genetic mutations.


Dr. P Kheirandish said, "It is recognized that the risk of prostate cancer is higher in black men than in white men worldwide" and "...Compares data from the United States (US), which suggest that African-American men have a 60% higher risk for developing prostate cancer with poorer prognosis in comparison with their white counterparts, with similar studies carried out in the United Kingdom (UK) and also in African and Caribbean countries".

The results clearly proposed if you are black men, you are associated with a substantially higher risk of prostate cancer. However, if you follow a healthy diet and lifestyle, your risk of the prostate can be reduced compared to other men in the same race group.

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.

The herbal medicine bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..

The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmitin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

The Korea Research Institute of Bioscience and Biotechnology, in the concern of mTOR Complex 2, a protein complex that regulates cellular metabolism may involve in the stimulation of the onset of prostate cancer, examined the effect of Aloe-emodin natural compound found in Cascara Sagrada and Aloe effect in prostate cancer cell line PC3.

Treatment of Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells through a number of mechanisms, including the regulation of cellular metabolism, proliferation, and migration.as well as tumor-promoting.

Furthermore, in vivo in an athymic nude mouse model, the injection of Aloe-emodin also exhibited tumor suppression effects.

The finding strongly suggested Aloe-emodin suppresses prostate cancer progression by targeting mTORC2, a protein complex that plays an important role in prostate cancer development.

The examination of the Emodin (ED), an anthraquinone derivative found in Cascara Sagrada effect in inhibiting the proliferation, induce apoptosis, suppress angiogenesis, impede metastasis, and enhance chemotherapy, researchers investigated the mechanism of ED related to the regulation of gene expression that affects cell migration and invasion in prostate cells.

In CXCR4/CXCL12 gene expression, involved in promoting invasion and metastasis in prostate tumor, injection of ED reduced the cancer proliferation and metastasis through inhibiting the CXCR4 expression.

Furthermore, researchers discovered, ED also reduced the expression of HER2 without affecting cell viability in tumor cells.

Moreover, The suppression of CXCR4 expression by ED was found to correlate with the inhibition of CXCL12-induced migration and invasion of DU145, a human prostate cancer cell line.


Additional differentiation of the efficacy of ED, researchers also found the inhibition of the expression of CXCR4 was associated with the mRNA expression through a protein (NF-κB ) which controls the transcription of DNA, cytokine production and cell survival.

Dr.Ok S, the lead researcher wrote in the final report, "ED is a novel blocker of CXCR4 expression and, thus, has enormous potential as a powerful therapeutic agent for metastatic cancer".

Taken altogether, Herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive compound Aloe-emodin and emodin may be considered a functional herb for the prevention and combined with other primary medicine for the treatment of prostate cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters

Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS.(PubMed)
(3) Ethnic differences in prostate cancer by P Kheirandish1,2,* and F Chinegwundoh. (PubMed)

Saturday, March 7, 2020

Herbal Angelica Modulates the Immune Response In Vivo

Immunomodulators are agents that have unique functions to modify the immune response or the functioning of the immune system such as the stimulation of antibody formation or the inhibition of abnormal white blood cell activity.

In other words, immunomodulation processed immunotherapy, in which immune responses are induced depending on the body's needs.

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

Besides foods and nutritional supplements, herbs also play important roles in helping the immune system to defend against viruses and bacteria attacks.

A variety of factors have been found to trigger immune responses include pathogens, damaged cells, and toxic compounds.

The immune response is a natural reaction of the immune system to protect our body against the invasion of foreign substances.


Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.

In the acute phase of infection, the immune system initiated the production of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro-inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.

These activities played an important in induced apoptosis and reduced proliferation of bacteria or viruses by attaching to the surface of the injured cells to initiation of an alternation. however, overproduction of pro-inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.

Type 1 T helper (Th1) in response to tissue damage and injure also activated macrophages that are responsible for cell-mediated immunity and phagocyte-dependent protective activity.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the modulation of the immune functioning, researchers examined the effects of Dangguibuxue Tang (DBT), including herbal angelica on the growth performance and immune response in immunosuppressed broiler chicks.

A total of 240 one-d-old broiler chicks (DaHeng S01)with 4 d to r7 d of age, in the study, were randomly divided into 4 groups, 2.0% DBT-treatment (A), 0.5% DBT-treatment (B), cyclophosphamide-control (C), and control group (D) from 8 d to 42 d of age, after the tested chicks in groups A, B and C were also given cyclophosphamide (CY) at a dosage of 100mg/kg body weight (BW) daily by intraperitoneal injection to induce immunosuppression.

Furthermore, the Chicks in the control group D were given an equal volume of physiological saline daily by intraperitoneal injection.

The experimental results suggested that compared to cyclophosphamide-control (C), chicks from group B has a lower feed gain rate (FGR), lower total mortality, higher immunity organ indexes.

Additionally, also compared to group C, chick in group B also demonstrated a significantly higher antiviral and infectious (Newcastle disease (ND) and infectious bursal disease (IBD)) antibody.

Moreover, the levels of pro-inflammatory cytokines induced by higher levels of interleukin-2 and interleukin-6 levels, and the response of greater lymphocyte proliferative responses to concanavalin A (ConAin) in the group B were also significantly lower compared to the group C.


In other words, Dangguibuxue Tang (DBT) displays strongly immune-modulatory effects regardless of the dose of herbal decode.

Based on the results, researchers said, "These results indicate that supplementation of 0.5% of DBT can improve both cellular immunity and humoral immunity in immunosuppressed broiler chicks".

Taken altogether, Herbal Angelica used alone or in the combination with other herbal medicines may be considered a function for improving immune response, pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Dangguibuxue Tang, a Chinese herbal medicine, on growth performance and immune responses in broiler chicks by Li XT1, Wang B, Li JL, Yang R, Li SC, Zhang M, Huang W, Cao L. (PubMed)

Ashwagandha Protects the Male Reproductive Functioning Against Arsenic Toxicity

Arsenic is a toxic chemical found in many minerals, usually in combination with other chemicals, including sulfur and metals.

Arsenic exposure can be acute or chronic
* Acute arsenic toxicity is caused by arsenic toxicity that induces symptoms of nausea, vomiting, abdominal pain, and severe diarrhea. In severe cases, the acute condition also causes encephalopathy and peripheral neuropathy.

* Chronic arsenic toxicity results in multisystem disease.

Chronic arsenic toxicity is also associated with liver and prostate cancer.

Recent studies suggested chronic arsenic toxicity also has a link to diabetes, neurological effects, cardiac disorders, and reproductive organs.


Infertility is defined as the inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to term.


The condition affects over 5 million couples alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seek help from a professional specialist.
Fertility is a natural process to ensure the survival of human species. Through natural selection, we produce many offsprings when the reproductive system works at its peak in a suitable environment.

Male infertility is a medical condition associated with the male's inability to cause pregnancy in a fertile female.

Male infertility accounts for 40–50% of all cases of infertility, affecting over 7% of all men.
Most cases of male infertility are the results of deficiencies in the semen, and semen quality that lead to reduced function of male fecundity.


The exact causes of male infertility are not identified. However, abnormal sperm production or function due to genetic defects, and medical conditions such as diabetes, or infectious diseases such as chlamydia, gonorrhea, mumps are some of the prevalent factors that are involved in the increased risk of male infertility.

On finding a potent compound for the prevention and treatment of diseases associated with arsenic
toxicity, researchers examined the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

Selected male Charles Foster rats were exposed to arsenic toxicity in the form of sodium arsenite by administered orally to for 45 days following the injection of the ethanolic root extract of Withania somnifera for 30 days.

According to the results, before the injection of the extract, sodium arsenite rats showed a decrease in sperm counts and sperm motility accompanied by an increased incidence of sperm abnormalities and hormonal imbalance that lead to infertility.

After the extract administration, Withania somnifera not only significantly reversed all the abnormal parameters through it's antioxidant and rejuvenating property but also maintained the cellular integrity of testicular cells.

In other words, Withania somnifera extract protected the integrity and viability of the testicular cells against the arsenic toxicity.

Based on the findings, researchers said, "Withania somnifera possesses phytoremedial effect. It is one of the best antidotes against arsenic-induced reproductive toxicity".

Taken altogether, Ashwagandha may be considered a functional herb for the protection of male reproductive organ functioning, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats by Kumar A1, Kumar R1, Rahman MS1, Iqubal MA1, Anand G1, Niraj PK1, Ali M. (PubMed)

Friday, March 6, 2020

Turmeric Protects Your Vision Against Eye Diseases

Eye diseases are the condition characterized by the change of vision, including a gradual loss of cells in the retina and neurons associated with the loss of vision.

Most eye diseases at the early stage are asymptomatic and painless with no change in the vision until the disease has become quite advanced.

People have an eye problem at one time and another. Most eye conditions are minor and go away sometimes without even noticing.

The most common causes of eye diseases are inflammation as a result of microbial infection, including bacterial, viral, parasitic or fungal infection, eye structure damage due to physical impact, genetic preposition due to mutation of certain associated with the vision, medical conditions such as diabetes and allergens.

In the elderly, eye diseases are caused by optic nerve damage and visual field loss, hormone change, aging induce loss of flexible eye small blood vessels and eye muscles due to aging,.... including age-related macular degeneration, glaucoma, cataract.

According to statistics, approximately one person in three has some form of vision-reducing eye disease by the age of 65 in the US. Age-related macular degeneration (AMD), glaucoma, cataract are the most prevalent eye disease found in the elderly.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural whole food or supplement for the treatment of eye disease, researchers examined curcumin, the major curcuminoid of the turmeric, used in many countries since ancient time for preventing and/or treating major anterior segment eye diseases.

In vitro and in vivo, curcumin showed beneficial effects on major anterior segment eye diseases, including the anti-angiogenesis effect in corneal diseases; anti-inflammation or anti-allergy effects in dry eye disease, conjunctivitis.
Injection of curcumin protected the eye against the attacks of free radicals and degradation in cataracts and neuroprotective effects in glaucoma.

In vitro, a novel nanocarrier formulation comprising Pluronic-F127 stabilized D-α-Tocopherol polyethylene glycol 1000 succinate nanoparticles, used to solubilize high concentrations (4.3 mg/mL) of curcumin exerted a significantly protect against cobalt chloride-induced hypoxia and glutamate-induced toxicity on the retinal cell line (R28).

In vivo, the novel nanocarrier formulation protects the eye against models of ocular hypertension (OHT) and partial optic nerve transection (pONT).

The findings strongly support the notion of curcumin and curcumin combined with other supplements extensively used in many countries since ancient times for preventing and/or treating a multitude of diseases including eye disease.

Also, the topical application of CN twice-daily for three weeks significantly reduced retinal ganglion cell loss compared to controls.

Dr, the lead scientist said, "Our novel topical CN formulation has potential as an effective neuroprotective therapy in glaucoma and other eye diseases with neuronal pathology".

Taken altogether, turmeric may be considered a supplement for the prevention and combined with primary medicine for the treatment of eye disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin, A Potential Therapeutic Candidate for Anterior Segment EyeDiseases: A Review by Liu XF1, Hao JL1, Xie T2, Mukhtar NJ1, Zhang W3, Malik TH4, Lu CW1, Zhou DD. (PubMed)
(2) Topical Curcumin Nanocarriers are Neuroprotective in Eye Disease by Davis BM1, Pahlitzsch M1, Guo L1, Balendra S1, Shah P1, Ravindran N1, Malaguarnera G1, Sisa C1, Shamsher E1, Hamze H1, Noor A1, Sornsute A2, Somavarapu S2, Cordeiro MF. (PubMed)

Cayenne, the Natural Whole Herb Medicine for treatment of Metabolic dysregulation

Cayenne may be the next herbal medicine in reduced risk and treatment of metabolic dysregulation, a recent study suggested

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to subtropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance the circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

Metabolic dysregulation refers to abnormal function of the body in regulation of glucose tolerance, fasting glucose, insulin resistance, dyslipidemia,...., leading to insulin resistance, type 2 diabetes, and fatty liver disease.

Capsaicin, the major chemical compound used dietary supplement attenuated metabolic dysregulation in genetically obese diabetic mice through by enhancing expression of modulation of glucose and lipid metabolism involving its receptors.

In obesity-induced inflammation and the development of obesity-related metabolic disorders, cayenne capsaicin suppressed inflammatory responses in inducing glucose intolerance and enhancing fatty acid oxidation in fat tissues, affecting insulin resistance.

The chemical compound involvement in reduced visceral adipose fat, also lowered serum levels of fasting glucose, total cholesterol, and triglycerides, probably through limited fat accumulation in adipose tissues and reduced inflammation and increased insulin sensitivity.

Dr. Leung FW. said," Clinical evidence supports the role of capsaicin as an anti-obesity agent. Both oral and gastrointestinal exposure to capsaicin increase satiety and reduce energy and fat intake and reduction in visceral abdominal fat" and "Thermogenesis and lipid metabolism-related proteins are altered upon capsaicin treatment in white adipose tissue".

Intake of cayenne for weight loss treatment-induced reduction in visceral abdominal fat may also improve the metabolic regulation. Quality of doses should only be given by specialists to prevent toxicity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice by Kang JH1, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R.(PubMed)
(2) Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet by Kang JH1, Goto T, Han IS, Kawada T, Kim YM, Yu R.(PubMed)
(3) Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice by Lee GR1, Shin MK, Yoon DJ, Kim AR, Yu R, Park NH, Han IS.(PubMed)