Hepatoprotection is the action including the use of a substance such as herbal remedy to protect the liver against damage and injury.
Antihepatotoxicity is the ability that protects the liver against toxins.
Acute liver diseases in most cases are caused by drugs and long-term intake of certain medications. Most acute liver disease can be cured if the cause is found.
Chronic liver diseases (CLD) are liver diseases that last more than 6 months. Most chronic liver diseases are caused by a genetic preposition or a variety of factors that damage the liver, including viruses and alcohol use.
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the world affecting 25% of the general population most of them in the Western world.
Some researchers suggested that the use of substances to protect the liver may involve several mechanisms, including strengthening the liver, gastrointestinal and immune system.
Dr. C. Girish, the lead scientists in the discussion of hepatoprotective effect, wrote, " The regulation of gastrointestinal system may improve the general well-being of the patients, as well as improvement of constipation, may prevent the absorption of harmful substances and indirectly decrease ascites (Langmead and Rampton, 2001). The protection of liver cells against toxic materials including drugs, lipid peroxidation, and free radical injury may decrease inflammation, improve liver blood flow, and ultimately help in the reduction of ascites and blood pressure (Yang et al., 2000)".
In other words, herbal medicine expressed liver protection not only by improving the blood flow to the liver but also through regulating the gastrointestinal system against the building up toxins in the induction of free radicals and suppressing the normal function of the liver and improving the immune system against inflammation-induced the lipid oxidation.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential ingredient for the protection of liver integrity, researchers examined curcumin, the active ingredient of turmeric therapeutic potential for the treatment of liver disorders.
Application of curcumin showed a liver protective activity by inhibiting the liver toxicity caused by long-term excessive alcohol drinking and acetaminophen, lindane, carbon tetrachloride (CCL4), diethylnitrosamine.
Furthermore, curcumin also restored the liver functioning in heavy metals induced hepatotoxicities models.
In the nonalcoholic fatty liver disease (NAFLD), the most common causes of the chronic liver disease model, researchers examined the Bisdemethoxycurcumin (BDMC), a polyphenolic compound derived from the Curcumae Longae Rhizoma liver protective activity.
The study included C57BL/6J mice divided into five groups of normal (normal diet without any treatment), methionine choline deficient (MCD)-diet (MCD diet only), MCD + silymarin (SIL) 100 mg/kg group, MCD + BDMC 100 mg/kg group, MCD + SIL 50 mg/kg + BDMC 50 mg/kg group.
BDMC protected the liver against fatty change compared to severe hepatic fatty accumulation in the MCD- diet group.
BDMC increased liver function significantly, compared to that of the loss of liver function in the MCD-diet group.
Most importantly, BDMC showed an inhibitory effect on liver lipogenesis by reducing associated gene expression caused by the MCD-diet.
Moreover, combinations of BDMC with SIL had a synergistic effect against MCD-diet models.
Based on the findings, Dr. Kim SB, the lead scientists said, "our findings indicate that BDMC has a potential suppressive effect on NAFLD. Therefore, our data suggest that BDMC may act as a novel and potent therapeutic agent against NAFLD".
Taken altogether, turmeric and its bioactive compound curcumin may be considered a remedy for the improvement of liver functioning, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) TMechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects by Khan H1, Ullah H2, Nabavi SM. (PubMed)
(2) Hepatoprotective Effect and Synergism of Bisdemethoxycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.
Kim SB1, Kang OH1, Lee YS2, Han SH3, Ahn YS3, Cha SW3, Seo YS1, Kong R2, Kwon DY. (PubMed)
(3) Herbal Drugs on the Liver by C. Girish, S.C. Pradhan, in Liver Pathophysiology, 2017, (Science Direct)
Tuesday, March 10, 2020
Dandelion(Taraxacum officinale), the Potential and Natural Anti-Inflammatory Remedy
Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.
Truly, the main focus of inflammation is to repair damage and injury.
Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Any inflammation that lasts more than 3 months is considered chronic inflammation.
Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.
Inflammation also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.
However, people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.
Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, DNA damage.
Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.
Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin) and other prescription NSAIDs.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of diseases associated with inflammation, scientists examined the mechanisms responsible for the anti-inflammation effects of water extract of T. mongolicum Hand.-Mazz (WETMHM) on lipopolysaccharide (LPS)-induced inflammatory in acute lung injury.
Female BALB/c mice selected to the investigation were randomly divided into five groups with 10 mice in each group: (1) control group (saline), (2) LPS group, (3) LPS+dexamethasone (LPS+Dex, 2mg/kg, administered by gavage), (4) LPS+WETMHM (5 g/kg, administered by gavage), (5) LPS+WETMHM (10 g/kg, administered by gavage).
According to the results from the tested analysis, treatment with the WETMHM exhibited a number of mechanisms against LPS-induced inflammation, including the
* Attenuating inflammation cell numbers in the BALF
* Decreasing the protein levels of lung PI3K/Akt/mTOR, and
* Improving the antioxidant activity of SOD.
* Inhibiting MPO activity associated with inflammation
Furthermore, the histological studies also demonstrated that WETMHM substantially inhibited LPS-induced neutrophils in lung tissue.
Based on the results, researchers suggest, " The results indicated that the WETMHM had a protective effect on LPS-induced ALI in mice".
Taken altogether, dandelion may be considered a remedy for the treatment of diseases associated with inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway by Ma C1, Zhu L1, Wang J1, He H1, Chang X1, Gao J1, Shumin W2, Yan T. (PubMed)
Truly, the main focus of inflammation is to repair damage and injury.
Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.
However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.
Any inflammation that lasts more than 3 months is considered chronic inflammation.
Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.
Inflammation also can be caused by overexpression of free radicals compared to the antioxidant enzymes in the body. This result can lead to an imbalance of the ratio of the levels of free radicals and antioxidants, the major cause of oxidative stress.
However, people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.
Longer-term oxidative stress in the body can also cause oxidative damage to biomolecules, including lipids, proteins, DNA damage.
Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.
Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin) and other prescription NSAIDs.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of diseases associated with inflammation, scientists examined the mechanisms responsible for the anti-inflammation effects of water extract of T. mongolicum Hand.-Mazz (WETMHM) on lipopolysaccharide (LPS)-induced inflammatory in acute lung injury.
Female BALB/c mice selected to the investigation were randomly divided into five groups with 10 mice in each group: (1) control group (saline), (2) LPS group, (3) LPS+dexamethasone (LPS+Dex, 2mg/kg, administered by gavage), (4) LPS+WETMHM (5 g/kg, administered by gavage), (5) LPS+WETMHM (10 g/kg, administered by gavage).
According to the results from the tested analysis, treatment with the WETMHM exhibited a number of mechanisms against LPS-induced inflammation, including the
* Attenuating inflammation cell numbers in the BALF
* Decreasing the protein levels of lung PI3K/Akt/mTOR, and
* Improving the antioxidant activity of SOD.
* Inhibiting MPO activity associated with inflammation
Furthermore, the histological studies also demonstrated that WETMHM substantially inhibited LPS-induced neutrophils in lung tissue.
Based on the results, researchers suggest, " The results indicated that the WETMHM had a protective effect on LPS-induced ALI in mice".
Taken altogether, dandelion may be considered a remedy for the treatment of diseases associated with inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway by Ma C1, Zhu L1, Wang J1, He H1, Chang X1, Gao J1, Shumin W2, Yan T. (PubMed)
Monday, March 9, 2020
Green Tea and Its polyphenol (-)-epigallocatechin-3-gallate EGCG Kill Over 84% of Endometrial Cancer Cells, Scientists Reveal
Scientists may have found a popular beverage that processes a significant effect in reducing risk and treatment of endometrial cancer, according to some studies.
Endometrial cancer is a medical condition characterized by cell growth uncontrollably in the endometrium.
At the late stage, the cancerous cell may travel a distance away from the original site to infect other organs and tissues.
Some researchers suggested that endometrial cancer is not caused by a single factor but a number of conditions.
Women who have a persistent irregular ovulation pattern due to conditions of polycystic ovary syndrome, obesity, and diabetes are associated with a higher risk of the disease.
The risk of endometrial cancer is also increased in women who are taking hormone therapy after menopause, containing estrogen.
The most common symptoms are persistently abnormal vaginal bleeding. If you are experiencing some of the above symptoms, you should see your doctor right the way to rule out the possibility.
The early stage of endometrial cancer is treated successfully by surgery, including removing the uterus.
Green tea, a precious drink which processed numbers of health benefit is known to almost everyone in Asia and the Western world.
In the experiment of green tea bioactive compounds against the progression of tumor xenografts of human endometrial cancer, researchers found that (-)-epigallocatechin-3-gallate EGCG demonstrates a significant effect in reduced risk of endometrial cancer development through the bioactive chemicals anti-tumor angiogenesis properties.
In fact, the anti-cancer active compound efficacy was attributed to the modulation of expression of vascular endothelial growth factor A (VEGFA) protein in the established new vessel to stimulate the onset of cancer and cancer cell proliferation and HIF-1 functions in the activated transcription of many genes, that regulate cellular and systemic homeostatic response to external changes to tumor growth.
Furthermore, application of EGCG also suppressed responses of chemokine (C-X-C motif) ligand 12 (CXCL12) in expression of multiple physiological processes, promoted invasion and metastasis of tumor cells in connected tissues of the uterine mucosa (endometrium), thus reducing the infiltration of VEGFA-expressing tumor-associated macrophages (TAMs) in supplying rapidly growing malignant tissues with essential nutrients and oxygen.
Additionally, further analysis also insisted that EGCG restricted secretion of vascular endothelial growth factor A (VEGFA) initiated endometrial cancer growth by inhibiting the function of PI3K/AKT/mTOR/HIF1α pathway in the regulation of many cellular processes, including cell survival, proliferation, and growth.
After taking account all findings, treatment with EGCG reduced risk of endometrial cancer onset may be results of EGCG suppressed secretion in both fronts, the decreased cancer cell-secreted VEGFA and inhibited TAM-secreted VEGFA in endometrial cancer progression.
Further differentiation, also showed that green tea polyphenol (-)-epigallocatechin-3-gallate reduced cancer expansion by suppressing the expression of proliferation markers which act indirectly to stimulate endometrial epithelial proliferation in estrogen receptor α, progesterone receptor, proliferating cell nuclear antigen and cyclin D1.
The overexpression of cyclin D1 has linked to the development and progression of cancer.
The proliferating cell nuclear antigen is a protein with the function of cell cycle regulation and/or DNA replication and DNA synthesis and DNA repair.
Importantly, the inhibition of EGCG also decreased the activation of ERK, the extracellular signal-regulated kinases protein in cancer cell division and down the expression of transcription factors fos and jun, the cellular immediate-early genes in the induced transient cancer cell division and differentiation processes.
The function of EGCG in reduced risk of endometrial cancer also expressed through Bcl-2-associated X protein, cleavage of caspase-3 and poly(ADP-ribose) polymerase actions in the induction of cancer cell apoptosis and suppression of antiapoptotic protein Bcl-2 (B-cell lymphoma 2).
Bcl-2-associated X is a protein with the function of anti- or pro-apoptotic regulators involved in a wide variety of cellular activities.
B-cell lymphoma 2, a family protein with a function in the regulation of cell apoptosis.
Cleavage of caspase-3 also is known as a critical executioner of apoptosis,
Poly(ADP-ribose) polymerase is a protein with function involved in a number of cellular processes, including programmed cell death.
Implicitly, application of EGCG also increased production of free radical expression in the initiated cytotoxic effect by reducing levels of antioxidant glutathione levels and activating the p38 in the induction of cancer cells death without inducing toxicity to normal cells
P38 mitogen-activated protein kinases (MAPKs) are activated by a wide range of cellular stresses in the response to inflammatory cytokines involved in cell differentiation, apoptosis, and autophagy.
Indeed, according to a systematic review of literature published on database of PubMed, Embase, Cochrane Library and China Biological Medicine Database up to February 2, 2015, researchers indicated that green tea consumption is associated with a reduced risk of EC (relative risk of .78) and each additional cup of green tea consumed per day decreased risk of developing EC by 11%.
Particularly, the intake of green tea associated with the attenuated risk of endometrial cancer was 84.33% compared to 5.07 % of black tea.
Taken together, green tea and its polyphenol (-)-epigallocatechin-3-gallate EGCG may be considered a functional food used conjunction with standard therapy in reducing risk and treatment of endometrial cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea, black tea consumption, and risk of endometrial cancer: a systematic review and meta-analysis by Zhou Q1, Li H2, Zhou JG3, Ma Y4, Wu T5, Ma H6.(PubMed)
(2) A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer by Wang J1, Man GCW2, Chan TH3, Kwong J1, Wang CC4. (PubMed)
(3) (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation by Manohar M1, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwivedi A.(PubMed)
Endometrial cancer is a medical condition characterized by cell growth uncontrollably in the endometrium.
At the late stage, the cancerous cell may travel a distance away from the original site to infect other organs and tissues.
Some researchers suggested that endometrial cancer is not caused by a single factor but a number of conditions.
Women who have a persistent irregular ovulation pattern due to conditions of polycystic ovary syndrome, obesity, and diabetes are associated with a higher risk of the disease.
The risk of endometrial cancer is also increased in women who are taking hormone therapy after menopause, containing estrogen.
The most common symptoms are persistently abnormal vaginal bleeding. If you are experiencing some of the above symptoms, you should see your doctor right the way to rule out the possibility.
The early stage of endometrial cancer is treated successfully by surgery, including removing the uterus.
Green tea, a precious drink which processed numbers of health benefit is known to almost everyone in Asia and the Western world.
In the experiment of green tea bioactive compounds against the progression of tumor xenografts of human endometrial cancer, researchers found that (-)-epigallocatechin-3-gallate EGCG demonstrates a significant effect in reduced risk of endometrial cancer development through the bioactive chemicals anti-tumor angiogenesis properties.
In fact, the anti-cancer active compound efficacy was attributed to the modulation of expression of vascular endothelial growth factor A (VEGFA) protein in the established new vessel to stimulate the onset of cancer and cancer cell proliferation and HIF-1 functions in the activated transcription of many genes, that regulate cellular and systemic homeostatic response to external changes to tumor growth.
Furthermore, application of EGCG also suppressed responses of chemokine (C-X-C motif) ligand 12 (CXCL12) in expression of multiple physiological processes, promoted invasion and metastasis of tumor cells in connected tissues of the uterine mucosa (endometrium), thus reducing the infiltration of VEGFA-expressing tumor-associated macrophages (TAMs) in supplying rapidly growing malignant tissues with essential nutrients and oxygen.
Additionally, further analysis also insisted that EGCG restricted secretion of vascular endothelial growth factor A (VEGFA) initiated endometrial cancer growth by inhibiting the function of PI3K/AKT/mTOR/HIF1α pathway in the regulation of many cellular processes, including cell survival, proliferation, and growth.
After taking account all findings, treatment with EGCG reduced risk of endometrial cancer onset may be results of EGCG suppressed secretion in both fronts, the decreased cancer cell-secreted VEGFA and inhibited TAM-secreted VEGFA in endometrial cancer progression.
Further differentiation, also showed that green tea polyphenol (-)-epigallocatechin-3-gallate reduced cancer expansion by suppressing the expression of proliferation markers which act indirectly to stimulate endometrial epithelial proliferation in estrogen receptor α, progesterone receptor, proliferating cell nuclear antigen and cyclin D1.
The overexpression of cyclin D1 has linked to the development and progression of cancer.
The proliferating cell nuclear antigen is a protein with the function of cell cycle regulation and/or DNA replication and DNA synthesis and DNA repair.
Importantly, the inhibition of EGCG also decreased the activation of ERK, the extracellular signal-regulated kinases protein in cancer cell division and down the expression of transcription factors fos and jun, the cellular immediate-early genes in the induced transient cancer cell division and differentiation processes.
The function of EGCG in reduced risk of endometrial cancer also expressed through Bcl-2-associated X protein, cleavage of caspase-3 and poly(ADP-ribose) polymerase actions in the induction of cancer cell apoptosis and suppression of antiapoptotic protein Bcl-2 (B-cell lymphoma 2).
Bcl-2-associated X is a protein with the function of anti- or pro-apoptotic regulators involved in a wide variety of cellular activities.
B-cell lymphoma 2, a family protein with a function in the regulation of cell apoptosis.
Cleavage of caspase-3 also is known as a critical executioner of apoptosis,
Poly(ADP-ribose) polymerase is a protein with function involved in a number of cellular processes, including programmed cell death.
Implicitly, application of EGCG also increased production of free radical expression in the initiated cytotoxic effect by reducing levels of antioxidant glutathione levels and activating the p38 in the induction of cancer cells death without inducing toxicity to normal cells
P38 mitogen-activated protein kinases (MAPKs) are activated by a wide range of cellular stresses in the response to inflammatory cytokines involved in cell differentiation, apoptosis, and autophagy.
Indeed, according to a systematic review of literature published on database of PubMed, Embase, Cochrane Library and China Biological Medicine Database up to February 2, 2015, researchers indicated that green tea consumption is associated with a reduced risk of EC (relative risk of .78) and each additional cup of green tea consumed per day decreased risk of developing EC by 11%.
Particularly, the intake of green tea associated with the attenuated risk of endometrial cancer was 84.33% compared to 5.07 % of black tea.
Taken together, green tea and its polyphenol (-)-epigallocatechin-3-gallate EGCG may be considered a functional food used conjunction with standard therapy in reducing risk and treatment of endometrial cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea, black tea consumption, and risk of endometrial cancer: a systematic review and meta-analysis by Zhou Q1, Li H2, Zhou JG3, Ma Y4, Wu T5, Ma H6.(PubMed)
(2) A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer by Wang J1, Man GCW2, Chan TH3, Kwong J1, Wang CC4. (PubMed)
(3) (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation by Manohar M1, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwivedi A.(PubMed)
Herbal Comfrey(Symphytum officinale L.), a Natural Treatment for Unilateral Ankle Sprains
Ankle sprains are the most common injury in the sport associated with overstretching of fibers or of the collagen of the ankle ligaments, causing the partial or complete disruption of the fibers.
In athletes with acute lateral ankle sprains, the balance ability in patients with acute lateral ankle sprain was significantly weaker. The weight-bearing on the nondominant limb was found to be significantly higher than on the dominant limb.
Treatment is totally depending on the severity of the condition, including
* Rest by avoiding activities that cause pain, swelling or discomfort.
* Ice treatment with an ice pack or ice slush bath immediately for 15 to 20 minutes and repeat every two to three to relieve pain and swelling.
* Compression is effective to stop swelling.
* Elevation
By keeping your foot elevated has been found to decrease pain and swelling.
And
* Medications
Over-the-counter pain relievers — such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve, others) or acetaminophen (Tylenol, others) have been used to manage the pain of a sprained ankle.
* Surgery
In some cases, surgery may be necessary if the repair a ligament that won't heal or won't heal properly, or the reconstruction of ligament tissues.
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound for the treatment of diseases associated with ankle pain, researchers compared the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains.
The observer-blind, randomized, multi-center clinical trial with two independent treatment groups "comfrey extract" and "diclofenac gel" (parallel-group design) included a total of 164 patients (82 in the comfrey group and 82 in the diclofenac group, intention-to-treat (ITT) analysis) was conducted by the Istituto Ortopedico Galeazzi.
According to the results of the tested assay, the area under the curve (AUC) of the difference of the tenderness values contra-lateral minus injured side, pain at rest and on movement, and swelling and ankle movement were significantly improved in the comfrey group, compared to the diclofenac group.
Furthermore, on average of mean difference comfrey extract minus diclofenac, the AUC was +61.1 h x N/cm2 greater for patients treated with comfrey extract compared to diclofenac group (95% confidence interval: 19.08; 103.09 h x N/cm2).
The difference between the two treatment groups was statistically significant (analysis of variance with factors "study drug", "center", and "drug x center interaction") as the comfrey group showed a far better result in the treatment of unilateral ankle sprains.
There were no side effects during the treatment periods in both groups.
Based on the findings, researchers said, " The re-evaluation of the data showed the superiority of the plant-based ointment over the diclofenac gel in the treatment of distortions".
Taken altogether, Comfrey plant-based ointment combined with other herbal medicine may be considered a remedy for the treatment of unilateral ankle sprains, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions) by D'Anchise R1, Bulitta M, Giannetti B. (PubMed)
In athletes with acute lateral ankle sprains, the balance ability in patients with acute lateral ankle sprain was significantly weaker. The weight-bearing on the nondominant limb was found to be significantly higher than on the dominant limb.
Treatment is totally depending on the severity of the condition, including
* Rest by avoiding activities that cause pain, swelling or discomfort.
* Ice treatment with an ice pack or ice slush bath immediately for 15 to 20 minutes and repeat every two to three to relieve pain and swelling.
* Compression is effective to stop swelling.
* Elevation
By keeping your foot elevated has been found to decrease pain and swelling.
And
* Medications
Over-the-counter pain relievers — such as ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve, others) or acetaminophen (Tylenol, others) have been used to manage the pain of a sprained ankle.
* Surgery
In some cases, surgery may be necessary if the repair a ligament that won't heal or won't heal properly, or the reconstruction of ligament tissues.
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound for the treatment of diseases associated with ankle pain, researchers compared the efficacy of comfrey extract to a commercial diclofenac (CAS 78213-16-8) preparation in the treatment of unilateral ankle sprains.
The observer-blind, randomized, multi-center clinical trial with two independent treatment groups "comfrey extract" and "diclofenac gel" (parallel-group design) included a total of 164 patients (82 in the comfrey group and 82 in the diclofenac group, intention-to-treat (ITT) analysis) was conducted by the Istituto Ortopedico Galeazzi.
According to the results of the tested assay, the area under the curve (AUC) of the difference of the tenderness values contra-lateral minus injured side, pain at rest and on movement, and swelling and ankle movement were significantly improved in the comfrey group, compared to the diclofenac group.
Furthermore, on average of mean difference comfrey extract minus diclofenac, the AUC was +61.1 h x N/cm2 greater for patients treated with comfrey extract compared to diclofenac group (95% confidence interval: 19.08; 103.09 h x N/cm2).
The difference between the two treatment groups was statistically significant (analysis of variance with factors "study drug", "center", and "drug x center interaction") as the comfrey group showed a far better result in the treatment of unilateral ankle sprains.
There were no side effects during the treatment periods in both groups.
Based on the findings, researchers said, " The re-evaluation of the data showed the superiority of the plant-based ointment over the diclofenac gel in the treatment of distortions".
Taken altogether, Comfrey plant-based ointment combined with other herbal medicine may be considered a remedy for the treatment of unilateral ankle sprains, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions) by D'Anchise R1, Bulitta M, Giannetti B. (PubMed)
Sunday, March 8, 2020
Dandelion (Taraxacum officinale), Inhibits the Breast Cancer Cells in Vitro
The breast is the tissue overlying the chest muscles. in women, breasts are made of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of the women's breasts is totally determined by the amount of fat.
Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.
Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.
Early-stage of breast cancer in most cases first noticed as a painless lump in the breast or armpit and most often is discovered by patients or patients partner or their doctors during a routine physical exam.
The early stage of breast cancer symptoms normally include
* Lump (mass) in the breast
* Lump in the armpit (lymph nodes)
* Nipple discharge (clear or bloody)
* Inverted or retracted nipple
* Scaly or pitted skin on nipple persistent tenderness of the breast
and Unusual breast pain or discomfort
At the advanced stage, breast cancer can travel a distance away to infect other healthy organs and tissues and induce symptoms of
* Bone pain (Secondary tumors in the bone)
* Shortness of breath (Secondary tumors in the lung)
* Unintentional weight loss and drop in appetite (Secondary tumors in the liver)
* Headaches, neurological pain or weakness (Secondary tumors in the nervous system)
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of cancer, scientists compared the anti-breast cancer effects of three aqueous extracts prepared from the mature leaves, flowers, and roots of Taraxacum officinale.
According to the tested differentiation
* The crude extract of the dandelion leaf (DLE) showed strong activity against the growth of MCF-7/AZ breast cancer cells associated with the signaling on the surface of the cell to the DNA in the nucleus of the cell in an ERK-dependent manner.
* The aqueous extracts of dandelion flower (DFE) and root (DRE) showed no effect on the growth of either cell line, however, DRE blocked the invasion of MCF-7/AZ breast cancer cells by decreasing phosphorylation levels of FAK and SRC involved in cancer cell adhesion.
* Additionally, breast cancer cell migration associated with matrix metalloproteinases also reduced by the injection DRE.
Based on the findings, researchers suggested, "This study provides new scientific data on TO and suggests that TO extracts or individual components present in the extracts may be of value as novel anti-cancer agents".
Taken altogether, Dandelion leaves and roots may be considered remedies for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells by Sigstedt SC1, Hooten CJ, Callewaert MC, Jenkins AR, Romero AE, Pullin MJ, Kornienko A, Lowrey TK, Slambrouck SV, Steelant WF. (PubMed)
Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.
Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.
Early-stage of breast cancer in most cases first noticed as a painless lump in the breast or armpit and most often is discovered by patients or patients partner or their doctors during a routine physical exam.
The early stage of breast cancer symptoms normally include
* Lump (mass) in the breast
* Lump in the armpit (lymph nodes)
* Nipple discharge (clear or bloody)
* Inverted or retracted nipple
* Scaly or pitted skin on nipple persistent tenderness of the breast
and Unusual breast pain or discomfort
At the advanced stage, breast cancer can travel a distance away to infect other healthy organs and tissues and induce symptoms of
* Bone pain (Secondary tumors in the bone)
* Shortness of breath (Secondary tumors in the lung)
* Unintentional weight loss and drop in appetite (Secondary tumors in the liver)
* Headaches, neurological pain or weakness (Secondary tumors in the nervous system)
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of cancer, scientists compared the anti-breast cancer effects of three aqueous extracts prepared from the mature leaves, flowers, and roots of Taraxacum officinale.
According to the tested differentiation
* The crude extract of the dandelion leaf (DLE) showed strong activity against the growth of MCF-7/AZ breast cancer cells associated with the signaling on the surface of the cell to the DNA in the nucleus of the cell in an ERK-dependent manner.
* The aqueous extracts of dandelion flower (DFE) and root (DRE) showed no effect on the growth of either cell line, however, DRE blocked the invasion of MCF-7/AZ breast cancer cells by decreasing phosphorylation levels of FAK and SRC involved in cancer cell adhesion.
* Additionally, breast cancer cell migration associated with matrix metalloproteinases also reduced by the injection DRE.
Based on the findings, researchers suggested, "This study provides new scientific data on TO and suggests that TO extracts or individual components present in the extracts may be of value as novel anti-cancer agents".
Taken altogether, Dandelion leaves and roots may be considered remedies for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells by Sigstedt SC1, Hooten CJ, Callewaert MC, Jenkins AR, Romero AE, Pullin MJ, Kornienko A, Lowrey TK, Slambrouck SV, Steelant WF. (PubMed)
Herbal Cascara Sagrada (Rhamnus purshiana), the Potent Anti-Prostate Cancer Functional Herb, Researcher Suggested
Scientists may have found a herbal medicine for the prevention and treatment of prostate cancer with no side effects, according to the studies.
Prostate cancer is a condition characterized by abnormal cell growth in prostate tissue.
Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate tissue.
Most prostate cancers are slow-growing. Enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Contrary to popular belief, as of today, prostate cancer no longer is a disease of aging male, it has a tendency to affect the younger age population, particularly to that of age group 20 -40.
According to the statistic, most men diagnosed with prostate cancer survival or died due to another disease instead of prostate cancer. In the US, approximately 2.9 million men who have been diagnosed with prostate cancer at some point are still alive today.
Also, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and the disease is the most common cancer in American men.
Researchers do not know the exact causes of prostate cancer. Epidemiological studies suggested age, family history, being obese or obese, genetic preposition, particularly a poor diet with high saturated and trans fat, red meat and processed food, and low fruits and vegetables and whole-grain are associated with the onset of prostate cancer.
Some researchers suggested ethnicity is a predictor involved in the development of the disease due to a number of genetic mutations.
Dr. P Kheirandish said, "It is recognized that the risk of prostate cancer is higher in black men than in white men worldwide" and "...Compares data from the United States (US), which suggest that African-American men have a 60% higher risk for developing prostate cancer with poorer prognosis in comparison with their white counterparts, with similar studies carried out in the United Kingdom (UK) and also in African and Caribbean countries".
The results clearly proposed if you are black men, you are associated with a substantially higher risk of prostate cancer. However, if you follow a healthy diet and lifestyle, your risk of the prostate can be reduced compared to other men in the same race group.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal medicine bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmitin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
The Korea Research Institute of Bioscience and Biotechnology, in the concern of mTOR Complex 2, a protein complex that regulates cellular metabolism may involve in the stimulation of the onset of prostate cancer, examined the effect of Aloe-emodin natural compound found in Cascara Sagrada and Aloe effect in prostate cancer cell line PC3.
Treatment of Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells through a number of mechanisms, including the regulation of cellular metabolism, proliferation, and migration.as well as tumor-promoting.
Furthermore, in vivo in an athymic nude mouse model, the injection of Aloe-emodin also exhibited tumor suppression effects.
The finding strongly suggested Aloe-emodin suppresses prostate cancer progression by targeting mTORC2, a protein complex that plays an important role in prostate cancer development.
The examination of the Emodin (ED), an anthraquinone derivative found in Cascara Sagrada effect in inhibiting the proliferation, induce apoptosis, suppress angiogenesis, impede metastasis, and enhance chemotherapy, researchers investigated the mechanism of ED related to the regulation of gene expression that affects cell migration and invasion in prostate cells.
In CXCR4/CXCL12 gene expression, involved in promoting invasion and metastasis in prostate tumor, injection of ED reduced the cancer proliferation and metastasis through inhibiting the CXCR4 expression.
Furthermore, researchers discovered, ED also reduced the expression of HER2 without affecting cell viability in tumor cells.
Moreover, The suppression of CXCR4 expression by ED was found to correlate with the inhibition of CXCL12-induced migration and invasion of DU145, a human prostate cancer cell line.
Additional differentiation of the efficacy of ED, researchers also found the inhibition of the expression of CXCR4 was associated with the mRNA expression through a protein (NF-κB ) which controls the transcription of DNA, cytokine production and cell survival.
Dr.Ok S, the lead researcher wrote in the final report, "ED is a novel blocker of CXCR4 expression and, thus, has enormous potential as a powerful therapeutic agent for metastatic cancer".
Taken altogether, Herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive compound Aloe-emodin and emodin may be considered a functional herb for the prevention and combined with other primary medicine for the treatment of prostate cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS.(PubMed)
(3) Ethnic differences in prostate cancer by P Kheirandish1,2,* and F Chinegwundoh. (PubMed)
Prostate cancer is a condition characterized by abnormal cell growth in prostate tissue.
Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate tissue.
Most prostate cancers are slow-growing. Enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.
Contrary to popular belief, as of today, prostate cancer no longer is a disease of aging male, it has a tendency to affect the younger age population, particularly to that of age group 20 -40.
According to the statistic, most men diagnosed with prostate cancer survival or died due to another disease instead of prostate cancer. In the US, approximately 2.9 million men who have been diagnosed with prostate cancer at some point are still alive today.
Also, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and the disease is the most common cancer in American men.
Researchers do not know the exact causes of prostate cancer. Epidemiological studies suggested age, family history, being obese or obese, genetic preposition, particularly a poor diet with high saturated and trans fat, red meat and processed food, and low fruits and vegetables and whole-grain are associated with the onset of prostate cancer.
Some researchers suggested ethnicity is a predictor involved in the development of the disease due to a number of genetic mutations.
Dr. P Kheirandish said, "It is recognized that the risk of prostate cancer is higher in black men than in white men worldwide" and "...Compares data from the United States (US), which suggest that African-American men have a 60% higher risk for developing prostate cancer with poorer prognosis in comparison with their white counterparts, with similar studies carried out in the United Kingdom (UK) and also in African and Caribbean countries".
The results clearly proposed if you are black men, you are associated with a substantially higher risk of prostate cancer. However, if you follow a healthy diet and lifestyle, your risk of the prostate can be reduced compared to other men in the same race group.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal medicine bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmitin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
The Korea Research Institute of Bioscience and Biotechnology, in the concern of mTOR Complex 2, a protein complex that regulates cellular metabolism may involve in the stimulation of the onset of prostate cancer, examined the effect of Aloe-emodin natural compound found in Cascara Sagrada and Aloe effect in prostate cancer cell line PC3.
Treatment of Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells through a number of mechanisms, including the regulation of cellular metabolism, proliferation, and migration.as well as tumor-promoting.
Furthermore, in vivo in an athymic nude mouse model, the injection of Aloe-emodin also exhibited tumor suppression effects.
The finding strongly suggested Aloe-emodin suppresses prostate cancer progression by targeting mTORC2, a protein complex that plays an important role in prostate cancer development.
The examination of the Emodin (ED), an anthraquinone derivative found in Cascara Sagrada effect in inhibiting the proliferation, induce apoptosis, suppress angiogenesis, impede metastasis, and enhance chemotherapy, researchers investigated the mechanism of ED related to the regulation of gene expression that affects cell migration and invasion in prostate cells.
In CXCR4/CXCL12 gene expression, involved in promoting invasion and metastasis in prostate tumor, injection of ED reduced the cancer proliferation and metastasis through inhibiting the CXCR4 expression.
Furthermore, researchers discovered, ED also reduced the expression of HER2 without affecting cell viability in tumor cells.
Moreover, The suppression of CXCR4 expression by ED was found to correlate with the inhibition of CXCL12-induced migration and invasion of DU145, a human prostate cancer cell line.
Additional differentiation of the efficacy of ED, researchers also found the inhibition of the expression of CXCR4 was associated with the mRNA expression through a protein (NF-κB ) which controls the transcription of DNA, cytokine production and cell survival.
Dr.Ok S, the lead researcher wrote in the final report, "ED is a novel blocker of CXCR4 expression and, thus, has enormous potential as a powerful therapeutic agent for metastatic cancer".
Taken altogether, Herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive compound Aloe-emodin and emodin may be considered a functional herb for the prevention and combined with other primary medicine for the treatment of prostate cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS.(PubMed)
(3) Ethnic differences in prostate cancer by P Kheirandish1,2,* and F Chinegwundoh. (PubMed)
Saturday, March 7, 2020
Herbal Angelica Modulates the Immune Response In Vivo
Immunomodulators are agents that have unique functions to modify the immune response or the functioning of the immune system such as the stimulation of antibody formation or the inhibition of abnormal white blood cell activity.
In other words, immunomodulation processed immunotherapy, in which immune responses are induced depending on the body's needs.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
Besides foods and nutritional supplements, herbs also play important roles in helping the immune system to defend against viruses and bacteria attacks.
A variety of factors have been found to trigger immune responses include pathogens, damaged cells, and toxic compounds.
The immune response is a natural reaction of the immune system to protect our body against the invasion of foreign substances.
Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.
In the acute phase of infection, the immune system initiated the production of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro-inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.
These activities played an important in induced apoptosis and reduced proliferation of bacteria or viruses by attaching to the surface of the injured cells to initiation of an alternation. however, overproduction of pro-inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.
Type 1 T helper (Th1) in response to tissue damage and injure also activated macrophages that are responsible for cell-mediated immunity and phagocyte-dependent protective activity.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound for the modulation of the immune functioning, researchers examined the effects of Dangguibuxue Tang (DBT), including herbal angelica on the growth performance and immune response in immunosuppressed broiler chicks.
A total of 240 one-d-old broiler chicks (DaHeng S01)with 4 d to r7 d of age, in the study, were randomly divided into 4 groups, 2.0% DBT-treatment (A), 0.5% DBT-treatment (B), cyclophosphamide-control (C), and control group (D) from 8 d to 42 d of age, after the tested chicks in groups A, B and C were also given cyclophosphamide (CY) at a dosage of 100mg/kg body weight (BW) daily by intraperitoneal injection to induce immunosuppression.
Furthermore, the Chicks in the control group D were given an equal volume of physiological saline daily by intraperitoneal injection.
The experimental results suggested that compared to cyclophosphamide-control (C), chicks from group B has a lower feed gain rate (FGR), lower total mortality, higher immunity organ indexes.
Additionally, also compared to group C, chick in group B also demonstrated a significantly higher antiviral and infectious (Newcastle disease (ND) and infectious bursal disease (IBD)) antibody.
Moreover, the levels of pro-inflammatory cytokines induced by higher levels of interleukin-2 and interleukin-6 levels, and the response of greater lymphocyte proliferative responses to concanavalin A (ConAin) in the group B were also significantly lower compared to the group C.
In other words, Dangguibuxue Tang (DBT) displays strongly immune-modulatory effects regardless of the dose of herbal decode.
Based on the results, researchers said, "These results indicate that supplementation of 0.5% of DBT can improve both cellular immunity and humoral immunity in immunosuppressed broiler chicks".
Taken altogether, Herbal Angelica used alone or in the combination with other herbal medicines may be considered a function for improving immune response, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of Dangguibuxue Tang, a Chinese herbal medicine, on growth performance and immune responses in broiler chicks by Li XT1, Wang B, Li JL, Yang R, Li SC, Zhang M, Huang W, Cao L. (PubMed)
In other words, immunomodulation processed immunotherapy, in which immune responses are induced depending on the body's needs.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
Besides foods and nutritional supplements, herbs also play important roles in helping the immune system to defend against viruses and bacteria attacks.
A variety of factors have been found to trigger immune responses include pathogens, damaged cells, and toxic compounds.
The immune response is a natural reaction of the immune system to protect our body against the invasion of foreign substances.
Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.
In the acute phase of infection, the immune system initiated the production of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro-inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.
These activities played an important in induced apoptosis and reduced proliferation of bacteria or viruses by attaching to the surface of the injured cells to initiation of an alternation. however, overproduction of pro-inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.
Type 1 T helper (Th1) in response to tissue damage and injure also activated macrophages that are responsible for cell-mediated immunity and phagocyte-dependent protective activity.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound for the modulation of the immune functioning, researchers examined the effects of Dangguibuxue Tang (DBT), including herbal angelica on the growth performance and immune response in immunosuppressed broiler chicks.
A total of 240 one-d-old broiler chicks (DaHeng S01)with 4 d to r7 d of age, in the study, were randomly divided into 4 groups, 2.0% DBT-treatment (A), 0.5% DBT-treatment (B), cyclophosphamide-control (C), and control group (D) from 8 d to 42 d of age, after the tested chicks in groups A, B and C were also given cyclophosphamide (CY) at a dosage of 100mg/kg body weight (BW) daily by intraperitoneal injection to induce immunosuppression.
Furthermore, the Chicks in the control group D were given an equal volume of physiological saline daily by intraperitoneal injection.
The experimental results suggested that compared to cyclophosphamide-control (C), chicks from group B has a lower feed gain rate (FGR), lower total mortality, higher immunity organ indexes.
Additionally, also compared to group C, chick in group B also demonstrated a significantly higher antiviral and infectious (Newcastle disease (ND) and infectious bursal disease (IBD)) antibody.
Moreover, the levels of pro-inflammatory cytokines induced by higher levels of interleukin-2 and interleukin-6 levels, and the response of greater lymphocyte proliferative responses to concanavalin A (ConAin) in the group B were also significantly lower compared to the group C.
In other words, Dangguibuxue Tang (DBT) displays strongly immune-modulatory effects regardless of the dose of herbal decode.
Based on the results, researchers said, "These results indicate that supplementation of 0.5% of DBT can improve both cellular immunity and humoral immunity in immunosuppressed broiler chicks".
Taken altogether, Herbal Angelica used alone or in the combination with other herbal medicines may be considered a function for improving immune response, pending to larger sample size and multicenter human study.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of Dangguibuxue Tang, a Chinese herbal medicine, on growth performance and immune responses in broiler chicks by Li XT1, Wang B, Li JL, Yang R, Li SC, Zhang M, Huang W, Cao L. (PubMed)
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