Antioxidants are stable atoms that inhibit oxidation caused by free radicals.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.
Believe it or not, free radicals also play a critical role in maintaining a certain body function. The Journal of Physiology showed that free radicals act as signal substances that cause the heart to beat with the correct force.
In healthy individuals, antioxidant enzymes produced by the liver are good enough to balance the free radical produced by the cell metabolism and external sources such as the air we breathe and the food we eat.
However, in people with a weakened immune system such as infants, children and the elderly, dietary sources from supplements, fruits and vegetables may be needed.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world.
The herbal medicine has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined in vitro and in vivo the antioxidant effects of 70% ethanol-water (v/v) leaf and root extracts of T. officinale (TOL and TOR, respectively).
The study included organ homogenate samples from Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats, treated by leaf extracts of TOL (500 mg/kg/day) and TOR (500 mg/kg/day) for 21 days.
Based on the results from the experiment, the antioxidant contents of ) polyphenol (4.35 ± 0.15 compared to 1.14 ± 0.01) and flavonoid (23.17 ± 0.14 compared to 3 ± 0.05) of TOL are significantly higher compared to TOR.
TOL exerted a significantly higher free radical scavenging activity (EC50 0.37 compared to 1.34 mg/mL) and total antioxidant capacities (82.56% compared to 61.54% ABTS, and 156 ± 5.28 compared to 40 ± 0.31 FRAP) compared to TOR.
Furthermore, both extracts inhibited the oxidative stress marker MDA levels and increased the total antioxidant capacity (TAC) without inducing toxicity with LD50 > 5000 mg/kg).
Collectively, T. officinale leaf extract possesses significant anti-oxidant effects that conferred significant in vivo antioxidant protection against free radical-mediated oxidative stress in L-NAME-induced hypertensive rats.
Taken altogether, dandelion may be considered a remedy for enhancing the antioxidant capacity against oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) In Vitro and In Vivo Antioxidant Properties of Taraxacum officinale in Nω-Nitro-l-Arginine Methyl Ester (L-NAME)-Induced Hypertensive Rats by Aremu OO1, Oyedeji AO2, Oyedeji OO3, Nkeh-Chungag BN4, Rusike CRS, (PubMed)
Tuesday, April 21, 2020
Monday, April 20, 2020
Herbal Turmeric Protects the Heart Against Cardiac Toxicity
Cardiac toxicity is a condition in which the heart has been damage to some extents caused by harmful chemicals, including toxins induced by the treatment of chemotherapy.
Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes
* Cardiomyopathy is a disorder caused a weaken or damage of heart muscle, affecting the heart rhythm or inducing the risk of heart failure.
* Myocarditis is a condition of inflammation of the heart, that can lead to changes in heart rhythm or heart failure.
* Pericarditis is a condition caused by the inflammation of the sac surrounding the heart, inducing chest pain or heart failure.
* Acute coronary syndromes that affect the blood flow due to blood vessel damage.
* Congestive heart failure is a result that affects the function of the heart in pumping blood throughout the body.
Conventionally, treatment of cardiac toxicity includes medication to control fluids, high blood pressure, and medications which improve heart functioning. If all aforementioned medications fail, a heart transplant may be necessary.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of cardiac toxicity scientists launched an investigation to determine whether curry intake reduces blood levels of heavy metals, according to the Korean National Health and Nutrition Examination Survey 2013 data.
1,350 participants selected for the study were randomly divided into either curry intake group with the consumption of a curry dish more than once a month over the previous year, or a non-curry intake group (n = 747).
According to the heavy metal analysis, the curry intake group showed significantly lower heavy metal blood concentrations (Pb, Hg, and Cd).
Furthermore, the levels of heavy metals in patients with hypertension (HTN) were significantly lower in the curry intake group compared to the nonhypertension group.
The levels of blood concentrations of heavy metals induced toxicity associated with the induction of hypertension were significantly lower compared to the placebo.
The results confirmed the correlation between blood heavy metal levels and HTN.
In other words, turmeric has a potential effect on reducing cardiac toxicity in the induction of abnormally blood pressure.
In order to obtain turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced cardiac toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorate the effect of DOX-induced cardiac toxicity.
Additionally, turmeric extract inhibited the DOX-induced increase in plasma cholesterol, LDH, associated with the increased risk of cardiovascular disease.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the cardiac,.....toxicities".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of cardiac toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean by Choi JW1, Oh C2, Shim SY1,3, Jeong S4, Kim HS5, Kim MS. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
Depending on the cells of the areas of the heart that have been damaged, cardiac toxicity includes
* Cardiomyopathy is a disorder caused a weaken or damage of heart muscle, affecting the heart rhythm or inducing the risk of heart failure.
* Myocarditis is a condition of inflammation of the heart, that can lead to changes in heart rhythm or heart failure.
* Pericarditis is a condition caused by the inflammation of the sac surrounding the heart, inducing chest pain or heart failure.
* Acute coronary syndromes that affect the blood flow due to blood vessel damage.
* Congestive heart failure is a result that affects the function of the heart in pumping blood throughout the body.
Conventionally, treatment of cardiac toxicity includes medication to control fluids, high blood pressure, and medications which improve heart functioning. If all aforementioned medications fail, a heart transplant may be necessary.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of cardiac toxicity scientists launched an investigation to determine whether curry intake reduces blood levels of heavy metals, according to the Korean National Health and Nutrition Examination Survey 2013 data.
1,350 participants selected for the study were randomly divided into either curry intake group with the consumption of a curry dish more than once a month over the previous year, or a non-curry intake group (n = 747).
According to the heavy metal analysis, the curry intake group showed significantly lower heavy metal blood concentrations (Pb, Hg, and Cd).
Furthermore, the levels of heavy metals in patients with hypertension (HTN) were significantly lower in the curry intake group compared to the nonhypertension group.
The levels of blood concentrations of heavy metals induced toxicity associated with the induction of hypertension were significantly lower compared to the placebo.
The results confirmed the correlation between blood heavy metal levels and HTN.
In other words, turmeric has a potential effect on reducing cardiac toxicity in the induction of abnormally blood pressure.
In order to obtain turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced cardiac toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorate the effect of DOX-induced cardiac toxicity.
Additionally, turmeric extract inhibited the DOX-induced increase in plasma cholesterol, LDH, associated with the increased risk of cardiovascular disease.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the cardiac,.....toxicities".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of cardiac toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean by Choi JW1, Oh C2, Shim SY1,3, Jeong S4, Kim HS5, Kim MS. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
Sunday, April 19, 2020
Herbal Angelica Processes Anti-Depression Activity in Vivo
Depression is a common and serious psychological illness, affecting the physical and mental functions of patients, including the ways patients feel, think and act.
Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.
There are many causes associated with the onset of depression, including genetics, changes in hormone levels, certain medical conditions, stress, grief or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome.
The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, loss of interest in friends, family, favorite activities, and sex.
Some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering and thoughts of harming themselves.
People who act out of the ordinary, consist of undesirable behavior result in impairment in the individual's functioning are considered to have abnormal behavior.
Undesirable behavior or abnormal behavior has been found in many patients with chronic depression.
According to the statistics, over 30 million Americans suffer from depression and the amount is increasing at an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.
Antidepressant is a type of conventional medicine used as a first-line treatment of depression.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a herbal medicine for the treatment of depression and depressive symptoms, researchers examined the antidepressant effects of PAPZ (Panax ginseng, Angelica Sinensis, Polygala tenuifolia Willd, and Ziziphi spinose Semen) on corticosterone (CORT) model of depression in mice.
According to the experimental results, the administration of PAPZ ameliorated depression-like phenotypes in the CORT model.
Furthermore, chronic PAPZ administration exhibited the protein expression of brain-derived neurotrophic factor (BDNF) in the hippocampal tissue of the depressive mice.
Moreover, levels of the antioxidant enzyme activity of superoxide dismutase were enhanced compared to the decrease of the levels of stress marker malondialdehyde levels in the hippocampal tissue.
Based on the evidence, researchers said, "PAPZ has therapeutic effects in a mice depression model through increasing protein expression of BDNF and improving the anti-oxidation ability of the brain".
Taken altogether, Herbal Angelica processes anti-depressant activity, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice by Chen H1, Huang Q2,3, Zhang S4,5, Hu K6, Xiong W7, Xiao L8, Cong R9, Liu Q10, Wang Z. (PubMed)
Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.
There are many causes associated with the onset of depression, including genetics, changes in hormone levels, certain medical conditions, stress, grief or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome.
The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, loss of interest in friends, family, favorite activities, and sex.
Some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering and thoughts of harming themselves.
People who act out of the ordinary, consist of undesirable behavior result in impairment in the individual's functioning are considered to have abnormal behavior.
Undesirable behavior or abnormal behavior has been found in many patients with chronic depression.
According to the statistics, over 30 million Americans suffer from depression and the amount is increasing at an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.
Antidepressant is a type of conventional medicine used as a first-line treatment of depression.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a herbal medicine for the treatment of depression and depressive symptoms, researchers examined the antidepressant effects of PAPZ (Panax ginseng, Angelica Sinensis, Polygala tenuifolia Willd, and Ziziphi spinose Semen) on corticosterone (CORT) model of depression in mice.
According to the experimental results, the administration of PAPZ ameliorated depression-like phenotypes in the CORT model.
Furthermore, chronic PAPZ administration exhibited the protein expression of brain-derived neurotrophic factor (BDNF) in the hippocampal tissue of the depressive mice.
Moreover, levels of the antioxidant enzyme activity of superoxide dismutase were enhanced compared to the decrease of the levels of stress marker malondialdehyde levels in the hippocampal tissue.
Based on the evidence, researchers said, "PAPZ has therapeutic effects in a mice depression model through increasing protein expression of BDNF and improving the anti-oxidation ability of the brain".
Taken altogether, Herbal Angelica processes anti-depressant activity, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice by Chen H1, Huang Q2,3, Zhang S4,5, Hu K6, Xiong W7, Xiao L8, Cong R9, Liu Q10, Wang Z. (PubMed)
Saturday, April 18, 2020
Herbal Dandelion (Taraxacum officinale) Reduces the Side Effect of Chemo Drug Induce-Anorexia
Eating Disorders are a group of abnormal eating habits associated with a person's preoccupation weight, involving either insufficient or excessive food intake.
Eating disorders can be classified into
* Anorexia nervosa is a type of eating disorder usually develop in the teen years and affects over 90% of females, because of excessive food restriction and irrational fear to become fat due to the wrongly influenced media as attractiveness is equated to thinness.
* Bulimia nervosa
Bulimia nervosa is a medical condition of consuming a large amount of food in a short amount of time or one setting (binge eating), followed by self-induced vomiting, and taking a laxative or diuretic and/or excessive exercise, etc. to compensate for the binge. Bulimia Nervosa also affects almost 90% of females.
* Binge eating disorder
Binge eating disorder is a medical condition of compulsive eating of huge amounts of food while feeling out of control and powerless to stop. It is a common eating disorder in the United States affecting 3.5% of females and 2% of males.
Most common symptoms of Anorexia nervosa are
* Weight loss, sometimes severe as a result of malnutrition.
* Refusal to maintain a normal or minimally above normal body mass index for their age and Dieting despite being thin or dangerously underweight
* Intense fear of gaining weight and primary or secondary amenorrhea
In the study Eating disorders. A review and update by Haller E. at the University of California indicated Anorexia nervosa is diagnosed when a person refuses to maintain his or her body weight over a minimally normal weight for age and height, such as 15% below that expected, has an intense fear of gaining weight, has a disturbed body image, and, in women, has primary or secondary amenorrhea(2).
* Obsession with calories and fat content of food and try to avoid eating altogether. They deny hunger and will usually avoid eating around others as well as avoiding situations where food might be present(3).
* Disturbance to body image the person hold of him/herself
In the study of Eating disorders. A review and update, Dr. E Haller indicated that anorexia Nervosa is diagnosed when a person refuses to maintain his or her body weight over a minimally normal weight for age and height, such as 15% below that expected, has an intense fear of gaining weight, has a disturbed body image, and, in women, has primary or secondary amenorrhea(4).
*Abdominal pain and distention
Anorexia nervosa is also associated with abdominal and with a sensation of elevated abdominal pressure.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the treatment of eating disorders in chemotherapy patients, scientists examined the anti-anorexia of herbal mixtures extracts LCBP‑Anocure‑16001‑3 (LA16001, LA16002, LA16003), composed of Atractylodes japonica, Angelica Gigas, Astragalus membranaceus, Lonicera japonica Thunb., Taraxacum Platycerium H. Dahlstedt and Prunella vulgaris var. Asiatica (Nakai) Hara.
In a cisplatin‑induced anorexia mouse model, treatment with LA16001 prevents body weight loss. However, all three extracts were demonstrated to improve food intake.
LA16001showed to altered expression levels of ghrelin, leptin, and interleukin‑6 associated with infection.
In other words, LA16001 modulated the interleukin‑6 activation of phosphring the caorylation of Janus kinase 1 and signal transducer and activator of transcription 3 during the course of infection induce-inflammation observed by the increase of the number of white blood cells and neutrophils.
Based on the findings, researchers said, " the herbal formula LA16001 may be able to prevent chemotherapy‑induced anorexia and may have potential as a novel therapeutic strategy for the adjuvant treatment of patients with cancer".
Taken altogether, dandelion may be used to enhance and prevent side effect in a combination with chemo drugs in chemotherapy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia by Woo SM1, Lee KM2, Lee GR2, Park JY2, Lee HJ2, Bahn HJ2, Yoon HS2, Kim JY2, Shin YC3, Cho SG4, Ko SG. (PubMed)
(2) Eating Disorders: Anorexia nervosa - Symptoms and Signs by Kyle J. Norton
Eating disorders can be classified into
* Anorexia nervosa is a type of eating disorder usually develop in the teen years and affects over 90% of females, because of excessive food restriction and irrational fear to become fat due to the wrongly influenced media as attractiveness is equated to thinness.
* Bulimia nervosa
Bulimia nervosa is a medical condition of consuming a large amount of food in a short amount of time or one setting (binge eating), followed by self-induced vomiting, and taking a laxative or diuretic and/or excessive exercise, etc. to compensate for the binge. Bulimia Nervosa also affects almost 90% of females.
* Binge eating disorder
Binge eating disorder is a medical condition of compulsive eating of huge amounts of food while feeling out of control and powerless to stop. It is a common eating disorder in the United States affecting 3.5% of females and 2% of males.
Most common symptoms of Anorexia nervosa are
* Weight loss, sometimes severe as a result of malnutrition.
* Refusal to maintain a normal or minimally above normal body mass index for their age and Dieting despite being thin or dangerously underweight
* Intense fear of gaining weight and primary or secondary amenorrhea
In the study Eating disorders. A review and update by Haller E. at the University of California indicated Anorexia nervosa is diagnosed when a person refuses to maintain his or her body weight over a minimally normal weight for age and height, such as 15% below that expected, has an intense fear of gaining weight, has a disturbed body image, and, in women, has primary or secondary amenorrhea(2).
* Obsession with calories and fat content of food and try to avoid eating altogether. They deny hunger and will usually avoid eating around others as well as avoiding situations where food might be present(3).
* Disturbance to body image the person hold of him/herself
In the study of Eating disorders. A review and update, Dr. E Haller indicated that anorexia Nervosa is diagnosed when a person refuses to maintain his or her body weight over a minimally normal weight for age and height, such as 15% below that expected, has an intense fear of gaining weight, has a disturbed body image, and, in women, has primary or secondary amenorrhea(4).
*Abdominal pain and distention
Anorexia nervosa is also associated with abdominal and with a sensation of elevated abdominal pressure.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the treatment of eating disorders in chemotherapy patients, scientists examined the anti-anorexia of herbal mixtures extracts LCBP‑Anocure‑16001‑3 (LA16001, LA16002, LA16003), composed of Atractylodes japonica, Angelica Gigas, Astragalus membranaceus, Lonicera japonica Thunb., Taraxacum Platycerium H. Dahlstedt and Prunella vulgaris var. Asiatica (Nakai) Hara.
In a cisplatin‑induced anorexia mouse model, treatment with LA16001 prevents body weight loss. However, all three extracts were demonstrated to improve food intake.
LA16001showed to altered expression levels of ghrelin, leptin, and interleukin‑6 associated with infection.
In other words, LA16001 modulated the interleukin‑6 activation of phosphring the caorylation of Janus kinase 1 and signal transducer and activator of transcription 3 during the course of infection induce-inflammation observed by the increase of the number of white blood cells and neutrophils.
Based on the findings, researchers said, " the herbal formula LA16001 may be able to prevent chemotherapy‑induced anorexia and may have potential as a novel therapeutic strategy for the adjuvant treatment of patients with cancer".
Taken altogether, dandelion may be used to enhance and prevent side effect in a combination with chemo drugs in chemotherapy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia by Woo SM1, Lee KM2, Lee GR2, Park JY2, Lee HJ2, Bahn HJ2, Yoon HS2, Kim JY2, Shin YC3, Cho SG4, Ko SG. (PubMed)
(2) Eating Disorders: Anorexia nervosa - Symptoms and Signs by Kyle J. Norton
Friday, April 17, 2020
Turmeric's Bioactive Compound Curcumin Protects Diabetics Against Diabetic cardiomyopathy
Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased the accumulation of fluid in the lungs.
Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.
* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.
* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.
The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.
At the early stage, most patients with diabetic cardiomyopathy are asymptomatic. However, mild left ventricular diastolic dysfunction with little effect on ventricular filling and concomitant hypertension or coronary artery disease has been found to be the early indication of diabetic cardiomyopathy in patients with diabetes.
Epidemiologically, the most common risk factors that increase the risk of diabetic cardiomyopathy. are insulin resistance, hyperinsulinemia, and hyperglycemia.
Conventionally, as of today, there is no effective treatment of diabetic cardiomyopathy. Medication used for the treatment of the condition is focusing on glycemic control and management of heart failure symptoms.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetic cardiomyopathy(DCM), researchers examined the effect of curcumin on modulating DCM and the mechanisms involved.
The study included an experimental diabetic rat model induced by a low dose of streptozotocin(STZ) combined with high energy intake on rats, followed by curcumin orally administrated at a dose of 100 or 200 mg · kg(-1) · d(-1), respectively.
Before the treatment of curcumin, induced DCM rats showed a declined systolic myocardial performance associated with myocardial hypertrophy and fibrosis accompanied by the metabolism abnormalities, aberrant myocardial enzymes, and increased AGEs (advanced glycation end-products) accumulation.
Increased levels of ROS and depletion of antioxidant enzymes were also found in the rat before pretreatment with curcumin, observed by increased oxidative stress markers.
Furthermore, levels of pro-apoptotic proteins and proinflammatory cytokines were also found to significantly increase in DCM rats.
After the injection of curcumin, researchers found that remarkably, the bioactive compound attenuated myocardial dysfunction, cardiac fibrosis, AGEs accumulation, oxidative stress, inflammation and apoptosis in the heart of diabetic rats.
In other words, curcumin protected the heart of DCM rats against the onset of diabetic cardiomyopathy(DCM).
Based on the results, researchers said, "these results suggest that curcumin may have great therapeutic potential in the treatment of DCM, and perhaps other cardiovascular disorders, by attenuating fibrosis, oxidative stress, inflammation, and cell death".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered a supplement for the prevention and treatment of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, A Polyphenolic Curcuminoid With Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy by Zheng J1, Cheng J2, Zheng S3, Feng Q3, Xiao X. (PubMed)
(2) Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats by Yu W1, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C. (PubMed)
Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.
* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.
* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.
The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.
At the early stage, most patients with diabetic cardiomyopathy are asymptomatic. However, mild left ventricular diastolic dysfunction with little effect on ventricular filling and concomitant hypertension or coronary artery disease has been found to be the early indication of diabetic cardiomyopathy in patients with diabetes.
Epidemiologically, the most common risk factors that increase the risk of diabetic cardiomyopathy. are insulin resistance, hyperinsulinemia, and hyperglycemia.
Conventionally, as of today, there is no effective treatment of diabetic cardiomyopathy. Medication used for the treatment of the condition is focusing on glycemic control and management of heart failure symptoms.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetic cardiomyopathy(DCM), researchers examined the effect of curcumin on modulating DCM and the mechanisms involved.
The study included an experimental diabetic rat model induced by a low dose of streptozotocin(STZ) combined with high energy intake on rats, followed by curcumin orally administrated at a dose of 100 or 200 mg · kg(-1) · d(-1), respectively.
Before the treatment of curcumin, induced DCM rats showed a declined systolic myocardial performance associated with myocardial hypertrophy and fibrosis accompanied by the metabolism abnormalities, aberrant myocardial enzymes, and increased AGEs (advanced glycation end-products) accumulation.
Increased levels of ROS and depletion of antioxidant enzymes were also found in the rat before pretreatment with curcumin, observed by increased oxidative stress markers.
Furthermore, levels of pro-apoptotic proteins and proinflammatory cytokines were also found to significantly increase in DCM rats.
After the injection of curcumin, researchers found that remarkably, the bioactive compound attenuated myocardial dysfunction, cardiac fibrosis, AGEs accumulation, oxidative stress, inflammation and apoptosis in the heart of diabetic rats.
In other words, curcumin protected the heart of DCM rats against the onset of diabetic cardiomyopathy(DCM).
Based on the results, researchers said, "these results suggest that curcumin may have great therapeutic potential in the treatment of DCM, and perhaps other cardiovascular disorders, by attenuating fibrosis, oxidative stress, inflammation, and cell death".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered a supplement for the prevention and treatment of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, A Polyphenolic Curcuminoid With Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy by Zheng J1, Cheng J2, Zheng S3, Feng Q3, Xiao X. (PubMed)
(2) Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats by Yu W1, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C. (PubMed)
Thursday, April 16, 2020
Herbal Cascara Sagrada's Emodin Which Inhibits Pancreatic Cancer Cells Against Spreading
Scientists may have found a functional herb bioactive compound which processes anti-pancreatic cancer activity with no side effects, some scientists suggested.
Pancreatic cancer is a medical and chronic condition characterized by irregular cells growth in the tissue of the pancreas.
In the early stage, pancreatic cancer starts on the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.
The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.
Some researchers suggested long-term use of tobacco, being overweight and obese, exposure to workplace chemicals, age, gender and family history are some prevalent risk factors of pancreatic cancer.
According to the statistic, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men and women. cancer accounts for 7% of all cancer deaths.
The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing effect.
Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the study to reaffirm the Emodin anti-pancreatic cancer effect through inducing apoptosis of pancreatic cancer cells and inhibit tumor growth, researchers at the Zhejiang University School of Medicine, launched an investigation to find out whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism.
In vitro and in vivo Emodin inhibited pancreatic cancer cell growth, induced apoptosis, and enhanced the anti-tumor effect of gemcitabine on pancreatic cancer cells by inhibiting the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), the protein in response to cellular survival
Emodin inhibited tumor angiogenesis in vitro and in implanted pancreatic cancer tissues, decreased the expression of angiogenesis-associated factors and reduced eNOS phosphorylation in cell proliferation.
However, Emodin had no effect on VEGFR expression in vivo.
Dr. Lin SZ, the lead author said, "emodin has a potential anti-tumor effect on pancreatic cancer via its dual role in the promotion of apoptosis and suppression of angiogenesis".
Additionally, in the examine the effects of an X-linked inhibitor of apoptosis (XIAP) and NF-κB in chemotherapy resistance in pancreatic cancer, researchers conducted an investigation of SW1990 cells treated by sodium chloride, gemcitabine, emodin or their combination (gemcitabine plus emodin).
The combination therapy of gemcitabine plus emodin) is more effective in inducing a significantly inhibited SW1990 cell growth and a higher percentage of apoptosis than monotherapy.
Gemcitabine upregulated the expression of XIAP and NF-κB, while emodin or emodin plus gemcitabine downregulated them compared to the control group in vitro.
In SW1990 cells established orthotopic pancreatic tumor models in nude mice. The combination of emodin and gemcitabine showed a significant reduction in the tumor to tumor (T/NT) ratio, Standardized uptake value (SUV) and tumor weight compared to monotherapy.
Dr. Wang ZH, the lead author after taking into account of co and confounders wrote:" emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo, which may be via the downregulation of NF-κB expression, thus inhibiting the expression of XIAP.".
Taken altogether, herbal Cascara sagrada process high amount of bioactive ingredient Emodon may be considered a function in the prevention and an adjunct therapy combined with chemo intervention of treatment of pancreatic cancer, pending to the results of large example size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
1. Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis by Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL. (PubMed)
2. Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo by Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ.(PubMed)
3. [Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada].[Article in Danish]" by Jacobsen C, Semb S, Kromann-Andersen H(PubMed)
4. "Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity" by Nadir A, Reddy D, Van Thiel DH. (PubMed)
5. "Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana" by Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ. (PubMed)
Pancreatic cancer is a medical and chronic condition characterized by irregular cells growth in the tissue of the pancreas.
In the early stage, pancreatic cancer starts on the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.
The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.
Some researchers suggested long-term use of tobacco, being overweight and obese, exposure to workplace chemicals, age, gender and family history are some prevalent risk factors of pancreatic cancer.
According to the statistic, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men and women. cancer accounts for 7% of all cancer deaths.
The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.
The herbal's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing effect.
Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
In the study to reaffirm the Emodin anti-pancreatic cancer effect through inducing apoptosis of pancreatic cancer cells and inhibit tumor growth, researchers at the Zhejiang University School of Medicine, launched an investigation to find out whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism.
In vitro and in vivo Emodin inhibited pancreatic cancer cell growth, induced apoptosis, and enhanced the anti-tumor effect of gemcitabine on pancreatic cancer cells by inhibiting the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), the protein in response to cellular survival
Emodin inhibited tumor angiogenesis in vitro and in implanted pancreatic cancer tissues, decreased the expression of angiogenesis-associated factors and reduced eNOS phosphorylation in cell proliferation.
However, Emodin had no effect on VEGFR expression in vivo.
Dr. Lin SZ, the lead author said, "emodin has a potential anti-tumor effect on pancreatic cancer via its dual role in the promotion of apoptosis and suppression of angiogenesis".
Additionally, in the examine the effects of an X-linked inhibitor of apoptosis (XIAP) and NF-κB in chemotherapy resistance in pancreatic cancer, researchers conducted an investigation of SW1990 cells treated by sodium chloride, gemcitabine, emodin or their combination (gemcitabine plus emodin).
The combination therapy of gemcitabine plus emodin) is more effective in inducing a significantly inhibited SW1990 cell growth and a higher percentage of apoptosis than monotherapy.
Gemcitabine upregulated the expression of XIAP and NF-κB, while emodin or emodin plus gemcitabine downregulated them compared to the control group in vitro.
In SW1990 cells established orthotopic pancreatic tumor models in nude mice. The combination of emodin and gemcitabine showed a significant reduction in the tumor to tumor (T/NT) ratio, Standardized uptake value (SUV) and tumor weight compared to monotherapy.
Dr. Wang ZH, the lead author after taking into account of co and confounders wrote:" emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo, which may be via the downregulation of NF-κB expression, thus inhibiting the expression of XIAP.".
Taken altogether, herbal Cascara sagrada process high amount of bioactive ingredient Emodon may be considered a function in the prevention and an adjunct therapy combined with chemo intervention of treatment of pancreatic cancer, pending to the results of large example size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
1. Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis by Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL. (PubMed)
2. Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo by Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ.(PubMed)
3. [Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada].[Article in Danish]" by Jacobsen C, Semb S, Kromann-Andersen H(PubMed)
4. "Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity" by Nadir A, Reddy D, Van Thiel DH. (PubMed)
5. "Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana" by Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ. (PubMed)
Wednesday, April 15, 2020
Herbal Turmeric Protects Your Skin Against Photo-Damage
Photodamage is a type of skin damage caused by long-term exposure to the sunlight or tanning bed.
Photodamage skin is one most common form of skin damage in the US, due to misunderstanding the benefits and adverse effects on light exposure.
Believe it or not, a quarter of lifetime sun exposure occurs before the end of the teenage years. Most cases of photo skin damage can also stimulate some unwanted skin conditions, including advanced aging or wrinkling, uneven skin, hyperpigmentation, telangiectasias, actinic keratoses liver, and age spots.
In severe cases, long-term photodamage skin can also lead to skin cancer. More people in the US are diagnosed with skin cancer each year than all other cancers combined.
According to the statistic, 1 in 5 Americans will develop skin cancer by the age of 70.
Conventionally, most cases of early-stage and mild damage of skin are treated by topical Levulan that remove scaly patches of actinic keratoses from your skin.
However, Laser surgery may be necessary, if the topical fails.
Dr. Jee SH, the lead scientist in the examination of the risk of photodamaged skin in the risk of skin cancer wrote, "Some workers in paraquat manufacturing, exposed to bipyridines, have developed pigmentation and keratosis on sun-exposed skin".
And, "This pathologic study proves that all the lesions showed either photodamage or skin cancer. The strong trend in the correlation between the severity of photodamage and exposure to bipyridine leads to speculation about the synergistic role of bipyridine exposure and the solar effect in causing these malignant and premalignant skin lesions".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the concerns of Ultraviolet B (UVB) irradiation in inducing skin photo-damage associated with the onset of a sunburn, erythema, photoaging, and photocarcinogenesis, researchers evaluated the protective effects of curcumin against acute photo-damage.
In hairless mice, topical application of curcumin exerted a kin protective effect by significantly inhibiting acute UVB (540 mJ cm-2 , for 3 successive days)-induced inflammatory cells, collagen accrementition derangement, and lipid peroxidation.
Additionally, the topical cream with curcumin also stimulated the NF-E2-related factor 2 (Nrf2) nuclear accumulation involved in skin defense on uncovered (Uncv) hairless mice skin.
In vitro, treatment of HaCaT cells with curcumin significantly attenuated acute UVB (300 mJ cm-2 ) tissue damage in releasing lactate dehydrogenase release (LDH) into the bloodstream.
Levels of intracellular reactive oxygen species production and DNA damage are also inhibited by the injection of curcumin by activating the expression of phase II detoxifying enzymes and promoting DNA repair activity.
Additional analysis of the skin protective activity of curcumin, researchers found that The photoprotective effect provided by curcumin was potentially associated with modulation of Nrf2-factor associated with antioxidant defense.
In order to reveal more information about the effects of turmeric anti-skin damage, researchers looked into the turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness.
The prospective, double-blind, randomized pilot study included 33 healthy participants were recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017 receive one of three interventions (placebo, turmeric or polyherbal combination tablets) and were told to take the intervention tablets by mouth twice daily for 4 weeks.
According to the results, the polyherbal combination group had a significant decrease in redness of 40% compared to baseline (P = 0.03) compared to that of placebo and turmeric groups with no statistically significant changes in image analysis-based facial redness.
Based on the findings, researchers said, "Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin used alone or combined with other phytochemical may be used for the prevention of skin photo-damage, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation-induced Photo-damage by Li H1, Gao A1, Jiang N1, Liu Q1, Liang B1, Li R1, Zhang E1, Li Z1, Zhu H. (PubMed)
(2) Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study by Vaughn AR1, Pourang A2, Clark AK2, Burney W2, Sivamani RK. (PubMed)
(3) Photodamage and skin cancer among paraquat workers by Jee SH1, Kuo HW, Su WP, Chang CH, Sun CC, Wang JD. (PubMed)
Photodamage skin is one most common form of skin damage in the US, due to misunderstanding the benefits and adverse effects on light exposure.
Believe it or not, a quarter of lifetime sun exposure occurs before the end of the teenage years. Most cases of photo skin damage can also stimulate some unwanted skin conditions, including advanced aging or wrinkling, uneven skin, hyperpigmentation, telangiectasias, actinic keratoses liver, and age spots.
In severe cases, long-term photodamage skin can also lead to skin cancer. More people in the US are diagnosed with skin cancer each year than all other cancers combined.
According to the statistic, 1 in 5 Americans will develop skin cancer by the age of 70.
Conventionally, most cases of early-stage and mild damage of skin are treated by topical Levulan that remove scaly patches of actinic keratoses from your skin.
However, Laser surgery may be necessary, if the topical fails.
Dr. Jee SH, the lead scientist in the examination of the risk of photodamaged skin in the risk of skin cancer wrote, "Some workers in paraquat manufacturing, exposed to bipyridines, have developed pigmentation and keratosis on sun-exposed skin".
And, "This pathologic study proves that all the lesions showed either photodamage or skin cancer. The strong trend in the correlation between the severity of photodamage and exposure to bipyridine leads to speculation about the synergistic role of bipyridine exposure and the solar effect in causing these malignant and premalignant skin lesions".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the concerns of Ultraviolet B (UVB) irradiation in inducing skin photo-damage associated with the onset of a sunburn, erythema, photoaging, and photocarcinogenesis, researchers evaluated the protective effects of curcumin against acute photo-damage.
In hairless mice, topical application of curcumin exerted a kin protective effect by significantly inhibiting acute UVB (540 mJ cm-2 , for 3 successive days)-induced inflammatory cells, collagen accrementition derangement, and lipid peroxidation.
Additionally, the topical cream with curcumin also stimulated the NF-E2-related factor 2 (Nrf2) nuclear accumulation involved in skin defense on uncovered (Uncv) hairless mice skin.
In vitro, treatment of HaCaT cells with curcumin significantly attenuated acute UVB (300 mJ cm-2 ) tissue damage in releasing lactate dehydrogenase release (LDH) into the bloodstream.
Levels of intracellular reactive oxygen species production and DNA damage are also inhibited by the injection of curcumin by activating the expression of phase II detoxifying enzymes and promoting DNA repair activity.
Additional analysis of the skin protective activity of curcumin, researchers found that The photoprotective effect provided by curcumin was potentially associated with modulation of Nrf2-factor associated with antioxidant defense.
In order to reveal more information about the effects of turmeric anti-skin damage, researchers looked into the turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness.
The prospective, double-blind, randomized pilot study included 33 healthy participants were recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017 receive one of three interventions (placebo, turmeric or polyherbal combination tablets) and were told to take the intervention tablets by mouth twice daily for 4 weeks.
According to the results, the polyherbal combination group had a significant decrease in redness of 40% compared to baseline (P = 0.03) compared to that of placebo and turmeric groups with no statistically significant changes in image analysis-based facial redness.
Based on the findings, researchers said, "Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin used alone or combined with other phytochemical may be used for the prevention of skin photo-damage, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation-induced Photo-damage by Li H1, Gao A1, Jiang N1, Liu Q1, Liang B1, Li R1, Zhang E1, Li Z1, Zhu H. (PubMed)
(2) Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study by Vaughn AR1, Pourang A2, Clark AK2, Burney W2, Sivamani RK. (PubMed)
(3) Photodamage and skin cancer among paraquat workers by Jee SH1, Kuo HW, Su WP, Chang CH, Sun CC, Wang JD. (PubMed)
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