The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.
Inflammation is a natural response of the immune system in which the macrophages of the first defense stimulates the production of blood palette to cover the wound in case of injury and production of proinflammatory cytokines to the site of infection to fence off the foreign pathogens.
Inflammation also can be triggered by the immune mistakenly attacked the body tissues in cases of autoimmune disease.
Neuroinflammation is a process of the immune system that responds to harmful pathogens that induced oxidative stress to the brain.
A nerve cell is a brain cell specialized in transmitting nerve impulses.
Neuroinflammation is a medical condition characterized by the inflammation of the central nervous tissues, including the brain and spinal cord.
There many risk factors associated with the onset of neuroinflammation similar to other tissues inflammation, including infection, traumatic brain injury, toxic metabolites, or autoimmunity.
In other words, neuroinflammation is a complex response to brain injury involving the activation of inflammatory cytokines and chemokines, and generation of reactive oxygen and nitrogen species.
Overnutrition in the Western world may be one of the main culprits associated with the widespread neuroinflammation in the aging population.
Neuroinflammatory disease can be acute or chronic. Chronic neuroinflammation that leads to the activation of glial cells and the recruitment of inflammatory cytokines into the brain is found to associate with neurodegenerative diseases.
Most cases of the neuroinflammatory disease associated with the loss of neuronal structure and function.can be measured by the typical inflammatory markers, including CSF Aβ1-42, tau and p-tau181, and a panel of 37 neuroinflammatory markers in patients with Alzheimer's disease.
Aswagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-ageing herbal medicine.
In the urgency to discover a natural ingredient for the prevention of chronic inflammatory diseases, researchers examined the neuroprotective activity of Ashwagandha (Withania somnifera) against the inflammation associated with neurodegeneration and cognitive impairments induced by systemic LPS administration using in vivo rat model system.
The study included young adult Wistar strain male albino rats randomized into four groups: (i) Control, (ii) LPS alone, (iii) LPS + ASH-WEX, (iv) ASH-WEX alone.
According to the tested analysis, orally administered ASH-WEX not only significantly suppressed the cognitive and motor-coordination impairments in rats, but also regulated the expression of various proteins involved in synaptic plasticity and neuronal cell survival.
In LPS-mediated microglial activation induced damage to neurons via direct cell to cell contact or through secretion of inflammatory mediators, the application of ASH-WEX and FIV pretreatment restored neurite outgrowth and protect neurons from apoptotic cell death.
In other words, LPS-induced neuroinflammation activated in microglial conditioned medium-treated neuronal cultures and microglial-neuronal co-culture were significantly demolished by the application of ASH-WEX.
Collectively, researchers said, "ASH-WEX can be used as a promising natural therapeutic remedial for the prevention of neurodegeneration and cognitive impairments associated with peripheral inflammation and neuroinflammation".
Taken altogether, Ashwagandha may be considered supplements for the prevention and treatment of neuroinflammation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation by Gupta M1, Kaur G. (PubMed)
Friday, May 22, 2020
Thursday, May 21, 2020
Herbal Bilberry Enhances the Gut Microbiota for Healthy Aging
Aging is the natural and biological process of growing older.
You can not stop the aging clock, but, you can delay the progression by taking some preventive actions, including living a healthy lifestyle accompanied by moderate exercise.
Healthy aging refers to the creation of a series of conditions that allow the aging population to live functionally without affected by serious chronic diseases or medical conditions (that are well managed).
The World Health Organization in the definition of healthy aging wrote, "healthy aging as the process of developing and maintaining the functional ability that enables wellbeing in older age” and "Functional ability is about having the capabilities that enable all people to be and do what they have reason to value".
In other words, healthy aging must comprise all the mental and physical capacities such as the ability to walk, think, see, hear and remember, particularly in bathing, dressing, and other independent living skills, such as shopping and housework.
Dr. Ruth Elaine Nieuwenhuis-Mark in the study of healthy aging as a disease wrote, "A popular theory in the aging literature since the early 1990s is the socioemotional selectivity theory (SST; Carstensen, 1992). SST was put forward as an attempt to explain the so-called “paradox of aging” which refers to the finding that while physical health tends to decline as we age subjective well-being may be maintained or even improve (Diener and Suh, 1998)".
And, "Focusing on normal aging as a disease could, therefore, be seen as a step-back for aging research rather than a move forward. Aging-as-disease proponents would argue however that their focus is on improving quality of life in our final years, not on increasing our lifespans per se".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers in an aim to a natural compound which processes antiaging property examined the effects of bilberry anthocyanin extract consumption in healthy aging and intestinal barrier function and digestive enzyme activity, through regulating the gut microbiota in aging rats.
The study included aging rats fed with the medium-dose bilberry anthocyanin extract (20 mg per kg bw per day) in the regulation of the intestinal function.
Consumption of the extract showed strong activity in the gut by allowing the bacteria beneficial in the intestine (Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7-group, and the Lachnospiraceae_NK4A136_group) to grow, and inhibiting the growth of harmful bacteria (Verrucomicrobia and Euryarchaeota).
However, high-dose bilberry anthocyanin extract consumption was found to induce the negative effect in alternating some intestinally beneficial bacteria.
Furthermore, bilberry anthocyanin extract consumption also decreased the activity of digestive enzymes in breaking down food correlated to the changes in bacterial composition, short-chain fatty acids, and the intestinal mucosal barrier.
In other words, bilberry anthocyanin extract consumption improved the digestive function without affecting the activity of the digestive enzyme which has been found in low levels in people with the digestive problem including the aging population.
Dr. Li J, the lead scientists said, " bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".
The finding suggested that bilberry anthocyanin extract has a significant anti-aging effect by optimizing the function of the digestive system through wide range mechanisms, including bacterial composition.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered an anti-aging remedy, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X1. (PubMed)
(2) The senescence-accelerated mouse-prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals by Schiborr C1, Schwamm D, Kocher A, Rimbach G, Eckert GP, Frank J. (PubMed)
(3) Healthy Aging as Disease? by Ruth Elaine Nieuwenhuis-Mark. (PubMed)
(4) What is Healthy Ageing? (WHO)
You can not stop the aging clock, but, you can delay the progression by taking some preventive actions, including living a healthy lifestyle accompanied by moderate exercise.
Healthy aging refers to the creation of a series of conditions that allow the aging population to live functionally without affected by serious chronic diseases or medical conditions (that are well managed).
The World Health Organization in the definition of healthy aging wrote, "healthy aging as the process of developing and maintaining the functional ability that enables wellbeing in older age” and "Functional ability is about having the capabilities that enable all people to be and do what they have reason to value".
In other words, healthy aging must comprise all the mental and physical capacities such as the ability to walk, think, see, hear and remember, particularly in bathing, dressing, and other independent living skills, such as shopping and housework.
Dr. Ruth Elaine Nieuwenhuis-Mark in the study of healthy aging as a disease wrote, "A popular theory in the aging literature since the early 1990s is the socioemotional selectivity theory (SST; Carstensen, 1992). SST was put forward as an attempt to explain the so-called “paradox of aging” which refers to the finding that while physical health tends to decline as we age subjective well-being may be maintained or even improve (Diener and Suh, 1998)".
And, "Focusing on normal aging as a disease could, therefore, be seen as a step-back for aging research rather than a move forward. Aging-as-disease proponents would argue however that their focus is on improving quality of life in our final years, not on increasing our lifespans per se".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers in an aim to a natural compound which processes antiaging property examined the effects of bilberry anthocyanin extract consumption in healthy aging and intestinal barrier function and digestive enzyme activity, through regulating the gut microbiota in aging rats.
The study included aging rats fed with the medium-dose bilberry anthocyanin extract (20 mg per kg bw per day) in the regulation of the intestinal function.
Consumption of the extract showed strong activity in the gut by allowing the bacteria beneficial in the intestine (Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7-group, and the Lachnospiraceae_NK4A136_group) to grow, and inhibiting the growth of harmful bacteria (Verrucomicrobia and Euryarchaeota).
However, high-dose bilberry anthocyanin extract consumption was found to induce the negative effect in alternating some intestinally beneficial bacteria.
Furthermore, bilberry anthocyanin extract consumption also decreased the activity of digestive enzymes in breaking down food correlated to the changes in bacterial composition, short-chain fatty acids, and the intestinal mucosal barrier.
In other words, bilberry anthocyanin extract consumption improved the digestive function without affecting the activity of the digestive enzyme which has been found in low levels in people with the digestive problem including the aging population.
Dr. Li J, the lead scientists said, " bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".
The finding suggested that bilberry anthocyanin extract has a significant anti-aging effect by optimizing the function of the digestive system through wide range mechanisms, including bacterial composition.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered an anti-aging remedy, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X1. (PubMed)
(2) The senescence-accelerated mouse-prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals by Schiborr C1, Schwamm D, Kocher A, Rimbach G, Eckert GP, Frank J. (PubMed)
(3) Healthy Aging as Disease? by Ruth Elaine Nieuwenhuis-Mark. (PubMed)
(4) What is Healthy Ageing? (WHO)
Wednesday, May 20, 2020
Bromelain, the Potential Prevention and Treatment of Flu Influenza
Influenza A, B, C, and D are 4 types of flu influenza. Influenza virus A and B are seasonal flu occurred during the fall, winter, and early spring, which causes sniffling, aching, coughing, and running and stuffy nose and fever, affecting over 20% of the general population.
Influenza virus types C in the virus family Orthomyxoviridae tends to cause mild upper respiratory infections, similar to those of cold.
Influenza D viruses only affect cattle.
Individuals who have influenza are usually recovered within one week and symptoms are gone within 2 weeks.
However, people with the immature and weakened immune system including young children under age 5, adults older than age 65, elderly in nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complications.
Pregnant women and women up to two weeks postpartum due to change in the immune system are more prone to influenza and influenza complications.
Most common H and N subtype are influenza A that has been mutated to affect the combination of human, swine, and bird flu viruses, including
* H1N1 - Swine Flu
H1N1 normally is only transmitted among pigs. However, as of today, H1N1 became the first flu pandemic in the world that causes respiratory illness.
* H5N1 - Bird Flu
H5N1 is the strain of influenza known as a bird or avian flu. Before, it is transmitted between birds, but today, it now can be passed from bird to human. The strain is dangerous to humans with high death rates.
The most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the prevention and treatment of influenza, researchers compared the effect of two preparations of bromeline ("Sigma Co., Catalogues' Nos. B2252 and B5144).s
According to the tested assay, in the influenza A(H1N1) virus, B5144 did not have any impact on it under similar experimental conditions.
Furthermore, B5144 also showed an incomplete effect on the influenza A(H3N2) virus with particles (with intact external coatings).
However, enzyme B2252 was effective for all viruses selected for testing, with the highest effect was noted for influenza A(H1N1) and B viruses.
In other words, not all bromlines are the same, some are more effective in the inhibition of viral influenza than the others.
Taken altogether, preparations of bromeline generation from bromelain may be considered a remedy for the prevention and treatment of influenza, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage by Wang W1, Suguitan AL Jr, Zengel J, Chen Z, Jin H. (PubMed)
(2) [The use of bromelain in obtaining the subviral particles of influenza A and B viruses].[Article in Russian] by Ivanova VT, Kordiukova LV, Manykin AA, Burtseva EI, Zagorskaia IuV, Oskerko TA, Slepushkin AN. (PubMed)
Influenza virus types C in the virus family Orthomyxoviridae tends to cause mild upper respiratory infections, similar to those of cold.
Influenza D viruses only affect cattle.
Individuals who have influenza are usually recovered within one week and symptoms are gone within 2 weeks.
However, people with the immature and weakened immune system including young children under age 5, adults older than age 65, elderly in nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complications.
Pregnant women and women up to two weeks postpartum due to change in the immune system are more prone to influenza and influenza complications.
Most common H and N subtype are influenza A that has been mutated to affect the combination of human, swine, and bird flu viruses, including
* H1N1 - Swine Flu
H1N1 normally is only transmitted among pigs. However, as of today, H1N1 became the first flu pandemic in the world that causes respiratory illness.
* H5N1 - Bird Flu
H5N1 is the strain of influenza known as a bird or avian flu. Before, it is transmitted between birds, but today, it now can be passed from bird to human. The strain is dangerous to humans with high death rates.
The most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the prevention and treatment of influenza, researchers compared the effect of two preparations of bromeline ("Sigma Co., Catalogues' Nos. B2252 and B5144).s
According to the tested assay, in the influenza A(H1N1) virus, B5144 did not have any impact on it under similar experimental conditions.
Furthermore, B5144 also showed an incomplete effect on the influenza A(H3N2) virus with particles (with intact external coatings).
However, enzyme B2252 was effective for all viruses selected for testing, with the highest effect was noted for influenza A(H1N1) and B viruses.
In other words, not all bromlines are the same, some are more effective in the inhibition of viral influenza than the others.
Taken altogether, preparations of bromeline generation from bromelain may be considered a remedy for the prevention and treatment of influenza, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage by Wang W1, Suguitan AL Jr, Zengel J, Chen Z, Jin H. (PubMed)
(2) [The use of bromelain in obtaining the subviral particles of influenza A and B viruses].[Article in Russian] by Ivanova VT, Kordiukova LV, Manykin AA, Burtseva EI, Zagorskaia IuV, Oskerko TA, Slepushkin AN. (PubMed)
Tuesday, May 19, 2020
Bilberry Protects the Retinal Ganglion Cell Integrity Against Vision Loss
Retinal ganglion cell (RGC) is a type of neuron in the innermost cellular layer of the retina of the eye. The neurons receive visual information and pass them to the brain.
Believe or not, the neurons also extract different aspects of the image before passing them to the brain.
According to the biological information from an animal model, retinal ganglion cells distributed evenly across the retina, with the density ranges from ∼3000 cells per mm2 to ∼600 cells per mm2 depending on the areas of distribution.
Certain neurodegenerative diseases have been found to induce the gradual loss of retinal ganglion cells. Alzheimer's' disease and disease associated with multiple system atrophy the loss of retinal ganglion cells showed a pattern resembling glaucoma.
However, in patients with Parkinson’s disease (PD) and Huntington’s disease, the loss of RGCs are found to resemble that of mitochondrial optic neuropathies.
Any structural damage of the retinal nerve fiber layer and optic nerve head, or functional damage can affect the RGC integrity.
Symptoms of retinal ganglion cell (RGC) loss is depended on the level of damage of the retinal nerve fiber layer and optic nerve head in the retina. Symptoms can be severe eye pain accompanied by nausea and vomiting, visual disturbance, blurred vision in patients with glaucoma.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency on finding a plant-based compound for the treatment of retinal damage, researchers evaluated the protective effects of a Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) on retinal ganglion cells (RGCs) against damage.
In vitro, retinal ganglion cells damage induced by free radical activation by injection of 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1, a peroxynitrite donor) and in vivo, N-methyl-D-aspartic acid (NMDA)-induced retinal damage in mice, researchers showed that VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and radical activation in RGC-5 associated with the initiation of damage of the retinal ganglion cells.
Lipid peroxidation in mouse forebrain homogenates involved the retinal damage was also reduced by all tested compounds in concentration and dose-dependent manner.
Furthermore, intravitreous injected VMA significantly inhibited the NMDA-induced morphological retinal damage and an increase in apoptosis of DNA fragments in the ganglion cell layer.
Based on the findings, researchers suggested that bioactive compounds isolated bilberry process neuroprotective effects through antioxidative properties in vitro and in vivo models of retinal diseases.
In order to obtain more information about bilberry protective property against the damage of retinal ganglion cells, scientists analyzed the bilberry extract anthocyanins on retinal ganglion cell (RGC) survival after optic nerve crush.
C57BL/6J mice selected for the study were administrated orally with anthocyanins in bilberry extract (100 mg/kg/day or 500 mg/kg/day).
According to the tested assays, all doses of anthocyanins in bilberry extract exhibited increased significantly levels of Grp78 and Grp94 associated with endoplasmic reticulum integrity and stress-induced autophagy in mice detected in the inner nuclear layer and ganglion cell layer of the retina, surrounding the RGCs.
Gene expression of Chop, Bax, and Atf4 increased associated with cellular stress, and the mediation of apoptosis in mice after optic nerve crush was also decreased significantly after oral bilberry extract administration.
In other words, retinal ganglion cell (RGC) survival was increased substantially after injecting anthocyanins in bilberry extract.
Dr. Nakamura O, the lead scientist after taking into account co and confounders wrote, "bilberry extract has a potential role in neuroprotective treatments for retinal injuries, such as those which occur in glaucoma".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the protection of retinal damage against retinal diseases, particularly in retinal degeneration, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry extract administration prevents retinal ganglion cell death in mice via the regulation of chaperone molecules under conditions of endoplasmic reticulum stress by Nakamura O1, Moritoh S1,2, Sato K1,3, Maekawa S1, Murayama N1, Himori N1, Omodaka K1,3, Sogon T4, Nakazawa T. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinalneuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H.(PubMed)
Believe or not, the neurons also extract different aspects of the image before passing them to the brain.
According to the biological information from an animal model, retinal ganglion cells distributed evenly across the retina, with the density ranges from ∼3000 cells per mm2 to ∼600 cells per mm2 depending on the areas of distribution.
Certain neurodegenerative diseases have been found to induce the gradual loss of retinal ganglion cells. Alzheimer's' disease and disease associated with multiple system atrophy the loss of retinal ganglion cells showed a pattern resembling glaucoma.
However, in patients with Parkinson’s disease (PD) and Huntington’s disease, the loss of RGCs are found to resemble that of mitochondrial optic neuropathies.
Any structural damage of the retinal nerve fiber layer and optic nerve head, or functional damage can affect the RGC integrity.
Symptoms of retinal ganglion cell (RGC) loss is depended on the level of damage of the retinal nerve fiber layer and optic nerve head in the retina. Symptoms can be severe eye pain accompanied by nausea and vomiting, visual disturbance, blurred vision in patients with glaucoma.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency on finding a plant-based compound for the treatment of retinal damage, researchers evaluated the protective effects of a Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) on retinal ganglion cells (RGCs) against damage.
In vitro, retinal ganglion cells damage induced by free radical activation by injection of 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1, a peroxynitrite donor) and in vivo, N-methyl-D-aspartic acid (NMDA)-induced retinal damage in mice, researchers showed that VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and radical activation in RGC-5 associated with the initiation of damage of the retinal ganglion cells.
Lipid peroxidation in mouse forebrain homogenates involved the retinal damage was also reduced by all tested compounds in concentration and dose-dependent manner.
Furthermore, intravitreous injected VMA significantly inhibited the NMDA-induced morphological retinal damage and an increase in apoptosis of DNA fragments in the ganglion cell layer.
Based on the findings, researchers suggested that bioactive compounds isolated bilberry process neuroprotective effects through antioxidative properties in vitro and in vivo models of retinal diseases.
In order to obtain more information about bilberry protective property against the damage of retinal ganglion cells, scientists analyzed the bilberry extract anthocyanins on retinal ganglion cell (RGC) survival after optic nerve crush.
C57BL/6J mice selected for the study were administrated orally with anthocyanins in bilberry extract (100 mg/kg/day or 500 mg/kg/day).
According to the tested assays, all doses of anthocyanins in bilberry extract exhibited increased significantly levels of Grp78 and Grp94 associated with endoplasmic reticulum integrity and stress-induced autophagy in mice detected in the inner nuclear layer and ganglion cell layer of the retina, surrounding the RGCs.
Gene expression of Chop, Bax, and Atf4 increased associated with cellular stress, and the mediation of apoptosis in mice after optic nerve crush was also decreased significantly after oral bilberry extract administration.
In other words, retinal ganglion cell (RGC) survival was increased substantially after injecting anthocyanins in bilberry extract.
Dr. Nakamura O, the lead scientist after taking into account co and confounders wrote, "bilberry extract has a potential role in neuroprotective treatments for retinal injuries, such as those which occur in glaucoma".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the protection of retinal damage against retinal diseases, particularly in retinal degeneration, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry extract administration prevents retinal ganglion cell death in mice via the regulation of chaperone molecules under conditions of endoplasmic reticulum stress by Nakamura O1, Moritoh S1,2, Sato K1,3, Maekawa S1, Murayama N1, Himori N1, Omodaka K1,3, Sogon T4, Nakazawa T. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinalneuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H.(PubMed)
Monday, May 18, 2020
Cranberry, the Potent Free Radical Scavenger
Free radicals are highly reactive atoms associated with an unpaired electron in the outermost ring produced internally by our body cell metabolism and externally by the environmental factors, including the air which we breathe and the food we eat.
In other words, any chemicals compounds or molecules which process oxygen atom can be free radicals after chemical interaction.
Believe it or not, free radical in moderate amounts is important for our body functions such as NO cardio-vessel relaxation. However, in high levels, free radicals have been found epidemiologically to damage the lipid, and protein and induce the alternation of healthy cell DNA.
Out of all damages caused by overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases, including free radical-mediated chain reaction, enzyme-mediated oxidation, and nonradical, non-enzymatic oxidation.
This chain of reaction can not be stopped until the electrons on the outermost ring of free radicals are paired or inhibited by antioxidants.
Free radical scavengers are antioxidants that process a specific function to prevent the forming of free radicals by removing them before they can damage vital components of the cell.
Dr. Slemmer JE, the lead scientist in the examination of free radical scavengers for the treatment of stroke wrote, "The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a common underlying mechanism of many neuropathologies, as they have been shown to damage various cellular components, including proteins, lipids, and DNA".
And "several acute and chronic pharmacological therapies that have been extensively studied in order to reduce ROS/RNS loads in cells and the subsequent oxidative stress, so-called "free-radical scavengers".
These results strongly suggested that antioxidants with free radical scavenging activity protect the body against the damage of various cellular components, including proteins, lipids, and DNA alternation in the initiation of diseases.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the cranberry antioxidative and protective effects of cranberry flavonoids in free radical-generating systems on mitochondrial ultrastructure.
In radical-generating systems, cranberry flavonoids effectively inhibit the generation of free radical nitric oxide (IC50 = 4.4 ± 0.4 µg/ml), superoxide anion radicals (IC50 = 2.8 ± 0.3 µg/ml) and hydroxyl radicals (IC50 = 53 ± 4 µg/ml).
1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) were scavenged at the concentration of 2.2 ± 0.3 µg/ml with the IC50.
Furthermore, cranberry flavonoids exerted the antioxidant and free radical scavenging activity against lipid peroxidation in liposomal membranes and glutathione oxidation in erythrocytes induced by UV irradiation or organic hydroperoxides.
Moreover, the phytochemical compound also decreased the rigidity of the outer leaflet of the liposomal membranes.
In the liver, cranberry flavonoids also displayed hepatoprotective potential by preventing rat liver mitochondrial damage.
Collectively, researchers said, "The mitochondria-addressed effects of flavonoids might be related both to radical-scavenging properties and modulation of various mitochondrial events".
Taken altogether, cranberry may be considered a free radical scavenging remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry flavonoids prevent toxic rat liver mitochondrial damage in vivo and scavenge free radicals in vitro by Lapshina EA1, Zamaraeva M2, Cheshchevik VT1, Olchowik-Grabarek E2, Sekowski S2, Zukowska I2, Golovach NG1, Burd VN1, Zavodnik IB. (PubMed)
(2) The natural food colorant Peonidin from cranberries as a potential radicalscavenger - A DFT based mechanistic analysis by Rajan VK1, Hasna CK1, Muraleedharan K2. (PubMed)
In other words, any chemicals compounds or molecules which process oxygen atom can be free radicals after chemical interaction.
Believe it or not, free radical in moderate amounts is important for our body functions such as NO cardio-vessel relaxation. However, in high levels, free radicals have been found epidemiologically to damage the lipid, and protein and induce the alternation of healthy cell DNA.
Out of all damages caused by overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases, including free radical-mediated chain reaction, enzyme-mediated oxidation, and nonradical, non-enzymatic oxidation.
This chain of reaction can not be stopped until the electrons on the outermost ring of free radicals are paired or inhibited by antioxidants.
Free radical scavengers are antioxidants that process a specific function to prevent the forming of free radicals by removing them before they can damage vital components of the cell.
Dr. Slemmer JE, the lead scientist in the examination of free radical scavengers for the treatment of stroke wrote, "The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a common underlying mechanism of many neuropathologies, as they have been shown to damage various cellular components, including proteins, lipids, and DNA".
And "several acute and chronic pharmacological therapies that have been extensively studied in order to reduce ROS/RNS loads in cells and the subsequent oxidative stress, so-called "free-radical scavengers".
These results strongly suggested that antioxidants with free radical scavenging activity protect the body against the damage of various cellular components, including proteins, lipids, and DNA alternation in the initiation of diseases.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers examined the cranberry antioxidative and protective effects of cranberry flavonoids in free radical-generating systems on mitochondrial ultrastructure.
In radical-generating systems, cranberry flavonoids effectively inhibit the generation of free radical nitric oxide (IC50 = 4.4 ± 0.4 µg/ml), superoxide anion radicals (IC50 = 2.8 ± 0.3 µg/ml) and hydroxyl radicals (IC50 = 53 ± 4 µg/ml).
1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) were scavenged at the concentration of 2.2 ± 0.3 µg/ml with the IC50.
Furthermore, cranberry flavonoids exerted the antioxidant and free radical scavenging activity against lipid peroxidation in liposomal membranes and glutathione oxidation in erythrocytes induced by UV irradiation or organic hydroperoxides.
Moreover, the phytochemical compound also decreased the rigidity of the outer leaflet of the liposomal membranes.
In the liver, cranberry flavonoids also displayed hepatoprotective potential by preventing rat liver mitochondrial damage.
Collectively, researchers said, "The mitochondria-addressed effects of flavonoids might be related both to radical-scavenging properties and modulation of various mitochondrial events".
Taken altogether, cranberry may be considered a free radical scavenging remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry flavonoids prevent toxic rat liver mitochondrial damage in vivo and scavenge free radicals in vitro by Lapshina EA1, Zamaraeva M2, Cheshchevik VT1, Olchowik-Grabarek E2, Sekowski S2, Zukowska I2, Golovach NG1, Burd VN1, Zavodnik IB. (PubMed)
(2) The natural food colorant Peonidin from cranberries as a potential radicalscavenger - A DFT based mechanistic analysis by Rajan VK1, Hasna CK1, Muraleedharan K2. (PubMed)
Sunday, May 17, 2020
Bromelain, the Natural Prevention and Treatment of Chronic Rhinosinusitis (RS) With No Side Effects
Rhinosinusitis (RS) is a condition associated with the inflammation of the sinuses and nasal cavity.
Chronic Rhinosinusitis (CRS) is an inflammation of the sinuses and nasal cavity that last more than 12 weeks.
According to statistics, the prevalence of CRS in Korea, Europe, and the US is approximately 7%, 10%, and 12%, respectively.
The exact causes of CRS are not identified. However, some researches suggested that infection that does not heal itself due to the inability of the immune system to destroy all the infectious pathogens in the acute phase of infection may play a critical role to the onset of the condition.
Symptoms of CRS are totally depending on the state of severity. Some patients may experience symptoms of facial pressure or pain, post-nasal drainage, nasal blockage, anosmia or hyposmia, or fatigue.
Conventionally, medications used for the treatment of CRS are focusing on reducing symptoms and improved quality of life, inclduing prescribed antibiotics in case of bacterial infection.
If all medicines fail, surgery may be necessary.
Out of many risk factors associated with the onset of CRS, some researchers suggested that cigarette smoking may have a strong and negative impact on the syndrome.
Dr. Douglas D. Reh, the lead scientist wrote, " Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS)".
And, "There is clear evidence in the literature that cigarette smoke, either through active smoking or passive exposure to SHS, contributes to CRS".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential ingredient for the treatment of chronic rhinosinusitis, researchers investigated the penetration of bromelain into sinonasal mucosa in patients with chronic rhinosinusitis (CRS), compared to the control group.
40 participants with CRS were divided into 2 groups equally either treated by bromelain derived from pineapple (Ananas comosus) or control.
Bromelain 500 mg tablet twice daily administered for 30 days in the treatment group displayed a significant effect in reduced inflammation in patients with CRS compared to control.
In other words, bromelain has an excellent distribution from blood to rhinosinusal mucosa in exhibition anti-inflammatory activity.
Based on the findings, researchers said, "Its (bromelain) diffusion ability may allow the use of bromelain as an anti-inflammatory agent in paranasal sinus pathologies".
In a pilot study, researchers evaluated the efficacy, tolerability, and impact on the quality of life (QoL) of bromelain tablets (500 FIP) in patients with chronic rhinosinusitis (CRS).
According to the results from 12 patients suffering from CRS with (CRS+NP) or without (CRS-NP) nasal polyps who had undergone prior sinus surgery, treatment with bromelain tablets (500 FIP) for 3 months, exerted a strong effect in symptom scores (Total Symptom Scores: TSS); a Total Rhinoscopy Score (TRS) and the Sinonasal Outcome Test 20 (SNOT-20 GAV) with no side effects.
Dr. Büttner L, the lead scientist wrote in the final report, "Preliminary results indicate good tolerability, symptom control, and improvement in QoL for the treatment of CRS using bromelain tablets (500 FIP)".
Taken altogether, bromelain may be considered supplements for the treatment of chronic rhinosinusitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain's penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis by Passali D1, Passali GC2, Bellussi LM1, Sarafoleanu C3, Loglisci M1, Manea C3, Iosif C4, Passali FM. (PubMed)
(2) Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis--a pilot study by Büttner L1, Achilles N, Böhm M, Shah-Hosseini K, Mösges R. (PubMed)
(3) Impact of Tobacco Smoke on Chronic Rhinosinusitis – A Review of the Literature by Douglas D. Reh, MD,1 Thomas S. Higgins, MD,1 and Timothy L. Smith, MD, MPH. (PMC)
Chronic Rhinosinusitis (CRS) is an inflammation of the sinuses and nasal cavity that last more than 12 weeks.
According to statistics, the prevalence of CRS in Korea, Europe, and the US is approximately 7%, 10%, and 12%, respectively.
The exact causes of CRS are not identified. However, some researches suggested that infection that does not heal itself due to the inability of the immune system to destroy all the infectious pathogens in the acute phase of infection may play a critical role to the onset of the condition.
Symptoms of CRS are totally depending on the state of severity. Some patients may experience symptoms of facial pressure or pain, post-nasal drainage, nasal blockage, anosmia or hyposmia, or fatigue.
Conventionally, medications used for the treatment of CRS are focusing on reducing symptoms and improved quality of life, inclduing prescribed antibiotics in case of bacterial infection.
If all medicines fail, surgery may be necessary.
Out of many risk factors associated with the onset of CRS, some researchers suggested that cigarette smoking may have a strong and negative impact on the syndrome.
Dr. Douglas D. Reh, the lead scientist wrote, " Environmental factors such as inhaled pollutants like cigarette smoke may play a significant role in diseases of the upper airway including chronic rhinosinusitis (CRS)".
And, "There is clear evidence in the literature that cigarette smoke, either through active smoking or passive exposure to SHS, contributes to CRS".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential ingredient for the treatment of chronic rhinosinusitis, researchers investigated the penetration of bromelain into sinonasal mucosa in patients with chronic rhinosinusitis (CRS), compared to the control group.
40 participants with CRS were divided into 2 groups equally either treated by bromelain derived from pineapple (Ananas comosus) or control.
Bromelain 500 mg tablet twice daily administered for 30 days in the treatment group displayed a significant effect in reduced inflammation in patients with CRS compared to control.
In other words, bromelain has an excellent distribution from blood to rhinosinusal mucosa in exhibition anti-inflammatory activity.
Based on the findings, researchers said, "Its (bromelain) diffusion ability may allow the use of bromelain as an anti-inflammatory agent in paranasal sinus pathologies".
In a pilot study, researchers evaluated the efficacy, tolerability, and impact on the quality of life (QoL) of bromelain tablets (500 FIP) in patients with chronic rhinosinusitis (CRS).
According to the results from 12 patients suffering from CRS with (CRS+NP) or without (CRS-NP) nasal polyps who had undergone prior sinus surgery, treatment with bromelain tablets (500 FIP) for 3 months, exerted a strong effect in symptom scores (Total Symptom Scores: TSS); a Total Rhinoscopy Score (TRS) and the Sinonasal Outcome Test 20 (SNOT-20 GAV) with no side effects.
Dr. Büttner L, the lead scientist wrote in the final report, "Preliminary results indicate good tolerability, symptom control, and improvement in QoL for the treatment of CRS using bromelain tablets (500 FIP)".
Taken altogether, bromelain may be considered supplements for the treatment of chronic rhinosinusitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain's penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis by Passali D1, Passali GC2, Bellussi LM1, Sarafoleanu C3, Loglisci M1, Manea C3, Iosif C4, Passali FM. (PubMed)
(2) Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis--a pilot study by Büttner L1, Achilles N, Böhm M, Shah-Hosseini K, Mösges R. (PubMed)
(3) Impact of Tobacco Smoke on Chronic Rhinosinusitis – A Review of the Literature by Douglas D. Reh, MD,1 Thomas S. Higgins, MD,1 and Timothy L. Smith, MD, MPH. (PMC)
Saturday, May 16, 2020
Herbal Bilberry Inhibits Oral Candida Biofilms Naturally and Effectively
Candida is a class of yeasts that cause fungal infections worldwide.
Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract.
Under normal circumstances, Candida albicans do not cause harmful effects, but overgrowth results in candidiasis.
Oral candidiasis is an oral condition infected by the fungal C. albicans found mostly in people with a weakened immune system including patients who are taking the immune-suppressive medicine.
Biofilms are microbial communities in which cells stick to each other and often also to a surface.
Symptoms of oral Candida overgrowth include worse in the damp day, persistence drowsiness, lack of coordination, headaches, mood swing, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor for early treatment.
There are many risk factors associated with Candida overgrowth including medical conditions that cause weakened immune system, inhalant medicine, low level of stomach acids, and pregnancy.
Some researchers suggested aging may be one of the major risk factors that cause Candida overgrowth
Dr. Aikaterini Flevari, the lead scientists said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".
And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding a potential herbal medicine against oral Candida biofilms., researchers examined the efficacy of cranberry fruit (Vaccinium macrocarpon Aiton) and two other red fruits (Vaccinium myrtillus L. and Malpighia punicifolia L.) on Candida albicans and Candida glabrata yeasts.
According to the low concentration added to the culture medium, the combined extract displayed significant anti-adhesion activity against Candida spp.
Furthermore, the pretreatment of surfaces with the extract also exerted a strong anti-adhesion activity mainly against C. glabrata yeasts and antibiofilm activity against C. albicans.
These results suggested that the extract inhibitory activity was dependent on concentration, species, and strain.
Moreover, observed the activity of three subfractions enriched in pro-anthocyanidins, researchers found that the components showed an anti-adhesion activity at low concentrations.
In other words, crude extracts of cranberry and Vaccinium myrtillus L. and Malpighia punicifolia L.) and their fractions process potential in the prevention of biofilms of C. glabrata.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanidins may be considered a functioning remedy against oral Candida biofilms, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Promising results of cranberry in the prevention of oral Candida biofilms by Girardot M1, Guerineau A, Boudesocque L, Costa D, Bazinet L, Enguehard-Gueiffier C, Imbert C. (PubMed)
Candida albicans is a member of a large group of an organism whose cells contain complex structures enclosed within the membranes, including yeast and mold that live among the gut flora in the human mouth and gastrointestinal tract.
Under normal circumstances, Candida albicans do not cause harmful effects, but overgrowth results in candidiasis.
Oral candidiasis is an oral condition infected by the fungal C. albicans found mostly in people with a weakened immune system including patients who are taking the immune-suppressive medicine.
Biofilms are microbial communities in which cells stick to each other and often also to a surface.
Symptoms of oral Candida overgrowth include worse in the damp day, persistence drowsiness, lack of coordination, headaches, mood swing, loss of balance, rashes, bad breath, dry mouth, and postnasal drip.
If you experience some of the aforementioned symptoms, please make sure you check with your doctor for early treatment.
There are many risk factors associated with Candida overgrowth including medical conditions that cause weakened immune system, inhalant medicine, low level of stomach acids, and pregnancy.
Some researchers suggested aging may be one of the major risk factors that cause Candida overgrowth
Dr. Aikaterini Flevari, the lead scientists said, "Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections".
And, "The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding a potential herbal medicine against oral Candida biofilms., researchers examined the efficacy of cranberry fruit (Vaccinium macrocarpon Aiton) and two other red fruits (Vaccinium myrtillus L. and Malpighia punicifolia L.) on Candida albicans and Candida glabrata yeasts.
According to the low concentration added to the culture medium, the combined extract displayed significant anti-adhesion activity against Candida spp.
Furthermore, the pretreatment of surfaces with the extract also exerted a strong anti-adhesion activity mainly against C. glabrata yeasts and antibiofilm activity against C. albicans.
These results suggested that the extract inhibitory activity was dependent on concentration, species, and strain.
Moreover, observed the activity of three subfractions enriched in pro-anthocyanidins, researchers found that the components showed an anti-adhesion activity at low concentrations.
In other words, crude extracts of cranberry and Vaccinium myrtillus L. and Malpighia punicifolia L.) and their fractions process potential in the prevention of biofilms of C. glabrata.
Taken altogether, bilberry processed abundantly bioactive compound anthocyanidins may be considered a functioning remedy against oral Candida biofilms, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Promising results of cranberry in the prevention of oral Candida biofilms by Girardot M1, Guerineau A, Boudesocque L, Costa D, Bazinet L, Enguehard-Gueiffier C, Imbert C. (PubMed)
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