Regular and daily moderate green tea intake may have a potential effect on increasing the lifespan in humans, some scientists suggested.
Some researchers suggested that human longevity without a health issues can be achieved through a healthy diet and lifestyle.
Dr. Small GW, the lead author in the study "A short-term healthy lifestyle program combining mental and physical exercise, stress reduction, and healthy diet was associated with significant effects on cognitive function and brain metabolism. Reduced resting activity in the left dorsolateral prefrontal cortex may reflect the greater cognitive efficiency of a brain region involved in working memory".
Would these results be enough for a person to live longer and healthier?
Eating the right foods can lead to a longer, healthier life. Some researchers recommended the following diet for the elderly to liver longevity without some major health issues.
* A basic heart-healthy diet including fruits and vegetables, whole grains, low-fat dairy products like yogurt and cheese, skinless poultry, lots of fish nuts and beans and non-tropical vegetable oils can help to control your weight because more than a third of people 65 and older are obese, the major cause of diabetes, some cancers, and heart disease.
* A basic brain-healthy diet including lean meats, deep-sea fish, skim milk products and some whole-grain cereals that reduces risk neurodegenerative disease can improve the memory.
* A basic protein diet to build the muscle diet including low-fat or fat-free yogurt, cheese, milk, lean meats, fish, other seafood, and beans.
* A basic diet including calcium and vitamin D in fortified foods, fish like salmon, and dairy products. to build the bone.
In the study to reaffirm the effect of green tea in increasing lifespan in various experimental animal models, researchers at the University of California Irvine launched an investigation to examine whether green tea acts to increase the lifespan of the fruit fly by modulating iron regulators, specifically, mitoferrin, a mitochondrial iron transporter, and transferrin, found in the hemolymph of flies
Application of green tea increased the lifespan of transferrin mutant lifespan but not the mitoferrin mutants and fertility, compared to the increased male fly lifespan and reduced male fertility in the non-mutant group.
These results suggested that green tea may act to increase the lifespan of Drosophila in part by the regulation of mitoferrin and reduction of mitochondrial iron.
Continued to the above investigation, researchers found that the lifespan extension properties of green tea were only observed in the presence of females which alludes to a reproductive (or mating) dependent mechanism.
Furthermore, the application of green tea exerted a strong and negatively impact on male fertility as shown by a reduced number of offspring produced and increased mating latency
These correlations suggested that green tea extends the lifespan of male flies by inhibiting reproductive potential, possibly by limiting iron uptake.
Researchers at the final report indicated green tea may have a profound effect in increasing lifespan but a negative effect on reproductive fitness in humans.
Moreover, in the study of a standardized epigallocatechin-3-gallate (EGCG) rich green tea extract (comprising > 90% EGCG) effects on fitness and lifespan as well as parameters of glucose metabolism and energy homeostasis in the fruit fly, Drosophila melanogaster, researchers found that
* The application of the green tea extract demonstrates a significant increase in the mean lifespan (+ 3.3 days) and the 50% survival (+ 4.3 days) as well as improved fitness
* These effects went along an increased expression of Spargel, the homolog of mammalian PGC1α whose dysfunction is associated with accelerated aging, decreased mobility and decreased lifespan.
* Treatment with the green tea extract decreased glucose concentrations.
Dr. Wagner AE, the lead scientist said, "a decrease in glucose metabolism in connection with an upregulated expression of Spargel contributes to the better fitness and the extended lifespan in EGCG-treated flies".
Taken all together, green tea may have a profound effect in increasing lifespan in human, depending on the confirmation of further data collection from the large example size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster by Lopez TE1, Pham HM1, Nguyen BV1, Tahmasian Y1, Ramsden S1, Coskun V1, Schriner SE1, Jafari M. (PubMed)
(2) Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness by Lopez T1, Schriner SE, Okoro M, Lu D, Chiang BT, Huey J, Jafari M.(PubMed)
(3) Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster by Wagner AE1, Piegholdt S1, Rabe D1, Baenas N1,2, Schloesser A1, Eggersdorfer M3, Stocker A4, Rimbach G. (PubMed)
(4) Effects of a 14-day healthy longevity lifestyle program on cognition and brain function by Small GW1, Silverman DH, Siddarth P, Ercoli LM, Miller KJ, Lavretsky H, Wright BC, Bookheimer SY, Barrio JR, Phelps ME. (PubMed)
(5) Foods for a Strong Heart, Brain, and Bones By John Donovan
Friday, June 5, 2020
Thursday, June 4, 2020
Herbal Turmeric Protects the Bone Cells Integrity Against Osteoporosis
Osteoporosis is a medical condition characterized by the loss of bone density.
In other words, the bone disease is a result of overexpression of bone loss due to bone resorption compared to bone made by the body, leading to risk bone fracture and breaking.
In a severe case, bones of patients with osteoporosis may become so weak, they can break from a fall or even from sneezing or minor bumps.
Microscopy, healthy bone processed a high density (fewer spaces and small holes in the honeycomb) compared to low density ( large spaces and holes in a honeycomb) in the patients with osteoporosis.
In the US, due to the widespread osteoporosis in the elderly, the disease has become a concern of the scientist community. Believe it or not, according to the statistics, osteoporosis is responsible for two million broken bones and $19 billion in related costs every year.
As the condition continues to worsen, by 2025, osteoporosis will be responsible for approximately three million fractures and $25.3 billion in costs annually.
According to the statistics, in Canada, osteoporosis affects approximately 1.4 million Canadians, mainly in postmenopausal women and the elderly.
Additionally, 1 in 4 women and more than 1 in 8 men over the age of 50 years, with 1 in 4 men and women are having evidence of a vertebral fracture.
Out of many risk factors associated with the onset of osteoporosis, some researchers suggested that the disease may be correlated to the promotion of Western diet over the past few decades.
Dr. Seon-Joo Park, the lead scientist wrote, "(In the comparison of ) "Three major dietary patterns,... using factor analysis based on baseline intake data: traditional (high intake of rice, kimchi, and vegetables), dairy (high intake of milk, dairy products, and green tea), and western (high intake of sugar, fat, and bread).".
And, "..., western dietary pattern (p-trend = 0.043 in radius) demonstrated a higher risk of osteoporosis incidence than those in the lowest quintile".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of osteoporosis, researchers evaluated the efficacy, in terms of changes in bone density, and safety of an oral formulation based on turmeric phytosome (Meriva®), in subjects suffering from low bone density.
The study included a total of 57 otherwise healthy subjects with low bone density who freely decided to follow either standard management (SM) to control low bone density (control group=28) or SM associated with a curcumin-based oral supplementation (supplement group=29).
Meriva®-supplemented group remarkably improved in the bone density of the heel measured by the Sahara densitometer accompanied by a significant decrease of ultrasounds transmission values at week 12 (-18.4%) and at week 24 (-21.0%), compared with baseline.
Furthermore, Meriva®-supplemented group also improved the bone densities of the small fingers and upper jaw with no adverse effects.
Based on the results researchers said, "This preliminary study suggests that a curcumin-based supplementation in combination with an appropriate lifestyle could be beneficial in the prevention and management of osteopenia".
In order to know more information about turmeric anti-osteoporosis activity, researchers examined the effects of curcumin on oxidative stress-induced osteoblast apoptosis.
The study included an osteoblastic cell line (Saos-2) exposed to various concentrations of H2O2 with or without curcumin treatment.
Injection of curcumin protected the viability of Saos-2 cells against the exposure to H2O2 and attenuated H2O2-induced apoptosis.
Furthermore, curcumin also improved the cellular function by preserving the mitochondrial redox potential, decreasing the mitochondrial oxidative status, through its antioxidants activity.
Moreover, curcumin treatment markedly increased levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK3β) that have been found to induced bone loss in low levels.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of curcumin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density: a preliminary 24-week supplement study by Riva A1, Togni S, Giacomelli L, Franceschi F, Eggenhoffner R, Feragalli B, Belcaro G, Cacchio M, Shu H, Dugall M. (PubMed)
(2) Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3β Signaling by Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang D, Zhou Y, Ni Z, Ma J, Huang S. (PubMed)
(3) Dietary Patterns and Osteoporosis Risk in Postmenopausal Korean Women by Seon-Joo Park, Seong-Eun Joo, Haesook Min, Jae Kyung Park, Yeonjung Kim, Sung Soo Kim, and Younjhin Ahn. (PMC)
In other words, the bone disease is a result of overexpression of bone loss due to bone resorption compared to bone made by the body, leading to risk bone fracture and breaking.
In a severe case, bones of patients with osteoporosis may become so weak, they can break from a fall or even from sneezing or minor bumps.
Microscopy, healthy bone processed a high density (fewer spaces and small holes in the honeycomb) compared to low density ( large spaces and holes in a honeycomb) in the patients with osteoporosis.
In the US, due to the widespread osteoporosis in the elderly, the disease has become a concern of the scientist community. Believe it or not, according to the statistics, osteoporosis is responsible for two million broken bones and $19 billion in related costs every year.
As the condition continues to worsen, by 2025, osteoporosis will be responsible for approximately three million fractures and $25.3 billion in costs annually.
According to the statistics, in Canada, osteoporosis affects approximately 1.4 million Canadians, mainly in postmenopausal women and the elderly.
Additionally, 1 in 4 women and more than 1 in 8 men over the age of 50 years, with 1 in 4 men and women are having evidence of a vertebral fracture.
Out of many risk factors associated with the onset of osteoporosis, some researchers suggested that the disease may be correlated to the promotion of Western diet over the past few decades.
Dr. Seon-Joo Park, the lead scientist wrote, "(In the comparison of ) "Three major dietary patterns,... using factor analysis based on baseline intake data: traditional (high intake of rice, kimchi, and vegetables), dairy (high intake of milk, dairy products, and green tea), and western (high intake of sugar, fat, and bread).".
And, "..., western dietary pattern (p-trend = 0.043 in radius) demonstrated a higher risk of osteoporosis incidence than those in the lowest quintile".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of osteoporosis, researchers evaluated the efficacy, in terms of changes in bone density, and safety of an oral formulation based on turmeric phytosome (Meriva®), in subjects suffering from low bone density.
The study included a total of 57 otherwise healthy subjects with low bone density who freely decided to follow either standard management (SM) to control low bone density (control group=28) or SM associated with a curcumin-based oral supplementation (supplement group=29).
Meriva®-supplemented group remarkably improved in the bone density of the heel measured by the Sahara densitometer accompanied by a significant decrease of ultrasounds transmission values at week 12 (-18.4%) and at week 24 (-21.0%), compared with baseline.
Furthermore, Meriva®-supplemented group also improved the bone densities of the small fingers and upper jaw with no adverse effects.
Based on the results researchers said, "This preliminary study suggests that a curcumin-based supplementation in combination with an appropriate lifestyle could be beneficial in the prevention and management of osteopenia".
In order to know more information about turmeric anti-osteoporosis activity, researchers examined the effects of curcumin on oxidative stress-induced osteoblast apoptosis.
The study included an osteoblastic cell line (Saos-2) exposed to various concentrations of H2O2 with or without curcumin treatment.
Injection of curcumin protected the viability of Saos-2 cells against the exposure to H2O2 and attenuated H2O2-induced apoptosis.
Furthermore, curcumin also improved the cellular function by preserving the mitochondrial redox potential, decreasing the mitochondrial oxidative status, through its antioxidants activity.
Moreover, curcumin treatment markedly increased levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK3β) that have been found to induced bone loss in low levels.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of curcumin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density: a preliminary 24-week supplement study by Riva A1, Togni S, Giacomelli L, Franceschi F, Eggenhoffner R, Feragalli B, Belcaro G, Cacchio M, Shu H, Dugall M. (PubMed)
(2) Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3β Signaling by Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang D, Zhou Y, Ni Z, Ma J, Huang S. (PubMed)
(3) Dietary Patterns and Osteoporosis Risk in Postmenopausal Korean Women by Seon-Joo Park, Seong-Eun Joo, Haesook Min, Jae Kyung Park, Yeonjung Kim, Sung Soo Kim, and Younjhin Ahn. (PMC)
Wednesday, June 3, 2020
Herbal Cascara Sagrada Chemotherapeutic and Mutated Gene Blocker Bioactive Components That Cut Off Energy Supply To Prostate Cancer Cells
Cascara sagrada may have a potential effect in inhibited onset and progression of prostate cancer, some scientists suggested.
Prostate cancer is medical a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body.
Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams. However, some protatecancers can grow and become invasive quickly.
According to the study of The University of Texas MD Anderson Cancer Center, metastasis to the bone caused by tumor/microenvironment interactions remains the major cause of death in advanced prostate cancer(3).
In other words, this invasion may be a result of certain cancer cells that can reseed the primary site and gain more metastatic potential in the process.
The exact causes of prostate cancer is unknown, however, certain conditions may associate to increase risk of prostate cancer, including age, ethnic group, family history,... and obesity.
Some researcher suggested that diet high in calcium is linked to an increased risk of developing prostate cancer and maternal high fat diet (HFD) is associated in increased risk children prostate cancer(4).
Most patients may not experience any symptoms until advance stage.
Most common symptoms includes frequent urination, lost of bladder control such as weak or interrupted urine flow or the need to strain to empty the bladder, the urge to urinate frequently at night. In severe cases, patients may also find blood in the urine and lost of erection.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belongings to the family Rhamnaceae, native to western North America,
The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The Ingredients
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Aloe-emodin, a chemical constituent found in Cascara Sagrada is found to inhibit both proliferation and anchorage-independent growth of PC3 cells by targeting the protein complex that plays an impotant role in stimulated cancer cell metabolism (mTORC2) for survival and expansion.
Further analysis also found that application of aloe-emodin also suppressed the function of Protein kinase B, (Akt) of cancer cell in signalling protection of cell survival, increased cell cycle progression and cellular growth and protein kinase C alpha (PKCα) in promotion of cancer cell migration.
Dr. Liu K, the lead author at The World Class Institute and Chemical Biology Research Center at the end of the experiment wrote, " Aloe-emodin (also) exhibited tumor suppression effects in vivo in an athymic nude mouse model" and "Collectively, our data suggest that mTORC2 plays an important role in prostate cancer development and aloe-emodin suppresses prostate cancer progression by targeting mTORC"
Epidemiologically, emodin (ED), another bioactive compound found in cascara sagrada, also processed anti proliferation and induced apoptosis, suppressed angiogenesis, impeded metastasis, and enhanced chemotherapy.
In DU145 and A549 cells, the application of emodin suppressed the expression of both mutation gene CXCR4 and HER2 which are associated to prorate cancer risk without affecting cell viability in tumor cells and protects healthy cell integrity against mutated gene CXCL12 in the induction of cancer cells migration and invasion.
Additional differentiation suggested, the efficacy of emodin in inhibited mutated gene expression of prostate cancer was attributed to the bioactive activity in prevetion of cancer cell in promoted mRNA expression and suppressed of NF-κB in the activation of cancer cells proliferation.
These results indicated that emodin may have a potential used as a novel blocker of CXCR4 expression as well as a powerful therapeutic agent for metastatic cancer.
The findings showed that, herbal Cascara Sagrada (Rhamnus purshiana) with bioactive components that have strong effects in inhibited prostate cancer cells may be considered as functional foods for treatment of prostate cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS.(PubMed)
(3) Steps in prostate cancer progression that lead to bone metastasis by Jin JK1, Dayyani F, Gallick GE(PubMed)
(4) Maternal High-Fat Diet Promotes the Development and Progression of Prostate Cancer in Transgenic Adenocarcinoma Mouse Prostate Offspring by Yang T1,2, Wu X1,2, Hu J1,2, Hu M1,2, Xu H1,2, Jiang H1,2, Ding Q(PubMed)
Prostate cancer is medical a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body.
Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams. However, some protatecancers can grow and become invasive quickly.
According to the study of The University of Texas MD Anderson Cancer Center, metastasis to the bone caused by tumor/microenvironment interactions remains the major cause of death in advanced prostate cancer(3).
In other words, this invasion may be a result of certain cancer cells that can reseed the primary site and gain more metastatic potential in the process.
The exact causes of prostate cancer is unknown, however, certain conditions may associate to increase risk of prostate cancer, including age, ethnic group, family history,... and obesity.
Some researcher suggested that diet high in calcium is linked to an increased risk of developing prostate cancer and maternal high fat diet (HFD) is associated in increased risk children prostate cancer(4).
Most patients may not experience any symptoms until advance stage.
Most common symptoms includes frequent urination, lost of bladder control such as weak or interrupted urine flow or the need to strain to empty the bladder, the urge to urinate frequently at night. In severe cases, patients may also find blood in the urine and lost of erection.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belongings to the family Rhamnaceae, native to western North America,
The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The Ingredients
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Aloe-emodin, a chemical constituent found in Cascara Sagrada is found to inhibit both proliferation and anchorage-independent growth of PC3 cells by targeting the protein complex that plays an impotant role in stimulated cancer cell metabolism (mTORC2) for survival and expansion.
Further analysis also found that application of aloe-emodin also suppressed the function of Protein kinase B, (Akt) of cancer cell in signalling protection of cell survival, increased cell cycle progression and cellular growth and protein kinase C alpha (PKCα) in promotion of cancer cell migration.
Dr. Liu K, the lead author at The World Class Institute and Chemical Biology Research Center at the end of the experiment wrote, " Aloe-emodin (also) exhibited tumor suppression effects in vivo in an athymic nude mouse model" and "Collectively, our data suggest that mTORC2 plays an important role in prostate cancer development and aloe-emodin suppresses prostate cancer progression by targeting mTORC"
Epidemiologically, emodin (ED), another bioactive compound found in cascara sagrada, also processed anti proliferation and induced apoptosis, suppressed angiogenesis, impeded metastasis, and enhanced chemotherapy.
In DU145 and A549 cells, the application of emodin suppressed the expression of both mutation gene CXCR4 and HER2 which are associated to prorate cancer risk without affecting cell viability in tumor cells and protects healthy cell integrity against mutated gene CXCL12 in the induction of cancer cells migration and invasion.
Additional differentiation suggested, the efficacy of emodin in inhibited mutated gene expression of prostate cancer was attributed to the bioactive activity in prevetion of cancer cell in promoted mRNA expression and suppressed of NF-κB in the activation of cancer cells proliferation.
These results indicated that emodin may have a potential used as a novel blocker of CXCR4 expression as well as a powerful therapeutic agent for metastatic cancer.
The findings showed that, herbal Cascara Sagrada (Rhamnus purshiana) with bioactive components that have strong effects in inhibited prostate cancer cells may be considered as functional foods for treatment of prostate cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
(2) Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 by Ok S, Kim SM, Kim C, Nam D, Shim BS, Kim SH, Ahn KS, Choi SH, Ahn KS.(PubMed)
(3) Steps in prostate cancer progression that lead to bone metastasis by Jin JK1, Dayyani F, Gallick GE(PubMed)
(4) Maternal High-Fat Diet Promotes the Development and Progression of Prostate Cancer in Transgenic Adenocarcinoma Mouse Prostate Offspring by Yang T1,2, Wu X1,2, Hu J1,2, Hu M1,2, Xu H1,2, Jiang H1,2, Ding Q(PubMed)
Tuesday, June 2, 2020
Turmeric, the Kitchen Spice Which Protects Liver Against Toxicity
Liver toxicity or hepatotoxicity is a condition that the liver is damaged by chemical substances, including drug-induced liver injury is a cause of acute and chronic liver disease.
The liver is the largest internal organ not only processes the function in filtering the blood coming from the intestine before passing them to other parts of the body but also secretes bile that aids the function of the digestive system in digest food, build strong cell membranes, production of vitamin D and steroid hormones.
Symptoms of liver toxicity may include stomach pain, upset stomach, persistent tiredness, dark-colored urine but light-colored bowel movements, particularly in the expression of jaundice found in the skin and eyes.
Other researchers suggested that psychological symptoms such as stress, anxiety and depression are also found in patients with liver toxicity.
The most common causes of liver toxicity are associated with drugs.
According to a critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury and 48 drugs had more than 50 case reports.
Believe it or not, amoxicillin-clavulanate has been found to induce liver toxicity in approximately one out of 2300 users.
However, according to the study published by the Journal of Phytopharmacology, live toxicity can also be caused by interruption of the liver function in metabolizing substances.
Dr. Meagan Thompson, the lead scientist wrote, " The human liver metabolizes substances via oxidation, reduction, hydration, hydrolysis, condensation, conjugation, or isomerization. Interruption of these processes can lead to hepatotoxicity, causing liver cancer, cirrhosis, and Hepatitis C, respectively".
And "Such diseases are responsible for higher mortality rates worldwide. The present review focuses on highlighting various plants that are hepatoprotective, hepatotoxic and the challenges faced by phytopharmaceuticals".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of liver toxicity scientists evaluated the therapeutic potential of Curcuma longa (200mgkg-1, po) and curcumin (80mgkg-1, po) for their hepatoprotective efficacy against mercuric chloride (HgCl2: 12μmolkg-1, ip; once only) hepatotoxicity.
According to the results from the testes assays, therapy of Curcuma longa or curcumin restored the HgCl2 administration that alters various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides, and cholesterol contents.
Furthermore, therapy of Curcuma longa extract or curcumin also inhibited a concomitant decline in the serum of protein and albumin concentration an indication of liver injury.
The findings suggested that Curcuma longa extract or curcumin processed the ability to alleviate the hepatotoxic effects caused by HgCl2 in rats.
In order to reveal more information about turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced liver toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorative effect against DOX-induced the increased serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin in liver tissue
According to the Biochemical and histopathological findings, turmeric extract has multiple therapeutic activities by ameliorating the effect against DOX-induced hepatotoxicity.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the hepatic....toxicities".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of liver toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach by Joshi D1, Mittal DK2, Shukla S2, Srivastav SK3, Dixit VA. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
(3) Hepatotoxicity by Drugs: The Most Common Implicated Agents by Einar S. Björnsson. (PMC)
(4) Hepatotoxicity: Treatment, causes and applications of medicinal plants as therapeutic agents by Meagan Thompson, Yogini Jaiswal, Ilya Wang, Leonard Williams( the Journal of Phytopharmacology)
The liver is the largest internal organ not only processes the function in filtering the blood coming from the intestine before passing them to other parts of the body but also secretes bile that aids the function of the digestive system in digest food, build strong cell membranes, production of vitamin D and steroid hormones.
Symptoms of liver toxicity may include stomach pain, upset stomach, persistent tiredness, dark-colored urine but light-colored bowel movements, particularly in the expression of jaundice found in the skin and eyes.
Other researchers suggested that psychological symptoms such as stress, anxiety and depression are also found in patients with liver toxicity.
The most common causes of liver toxicity are associated with drugs.
According to a critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury and 48 drugs had more than 50 case reports.
Believe it or not, amoxicillin-clavulanate has been found to induce liver toxicity in approximately one out of 2300 users.
However, according to the study published by the Journal of Phytopharmacology, live toxicity can also be caused by interruption of the liver function in metabolizing substances.
Dr. Meagan Thompson, the lead scientist wrote, " The human liver metabolizes substances via oxidation, reduction, hydration, hydrolysis, condensation, conjugation, or isomerization. Interruption of these processes can lead to hepatotoxicity, causing liver cancer, cirrhosis, and Hepatitis C, respectively".
And "Such diseases are responsible for higher mortality rates worldwide. The present review focuses on highlighting various plants that are hepatoprotective, hepatotoxic and the challenges faced by phytopharmaceuticals".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of liver toxicity scientists evaluated the therapeutic potential of Curcuma longa (200mgkg-1, po) and curcumin (80mgkg-1, po) for their hepatoprotective efficacy against mercuric chloride (HgCl2: 12μmolkg-1, ip; once only) hepatotoxicity.
According to the results from the testes assays, therapy of Curcuma longa or curcumin restored the HgCl2 administration that alters various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides, and cholesterol contents.
Furthermore, therapy of Curcuma longa extract or curcumin also inhibited a concomitant decline in the serum of protein and albumin concentration an indication of liver injury.
The findings suggested that Curcuma longa extract or curcumin processed the ability to alleviate the hepatotoxic effects caused by HgCl2 in rats.
In order to reveal more information about turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced liver toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorative effect against DOX-induced the increased serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin in liver tissue
According to the Biochemical and histopathological findings, turmeric extract has multiple therapeutic activities by ameliorating the effect against DOX-induced hepatotoxicity.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the hepatic....toxicities".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of liver toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach by Joshi D1, Mittal DK2, Shukla S2, Srivastav SK3, Dixit VA. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
(3) Hepatotoxicity by Drugs: The Most Common Implicated Agents by Einar S. Björnsson. (PMC)
(4) Hepatotoxicity: Treatment, causes and applications of medicinal plants as therapeutic agents by Meagan Thompson, Yogini Jaiswal, Ilya Wang, Leonard Williams( the Journal of Phytopharmacology)
Monday, June 1, 2020
Chamomile, The Whole Herb medicine for Wound Healing
Herbal chamomile expressed significantly wound healing effect against injure and bacterial invasion induced more damage to the wound.
According to the Shiraz University of Medical Sciences, C. nobile therapy at 5% C. nobile ointment was an effective antibacterial activity and accelerated the progression of wound healing, in vivo.
Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Wound healing is a natural stage of recover of body injure.
In a Wistar male rats (210.0±4.2 g) divided into five groups: negative control group (NCG) without diabetes; positive control group (PCG) with DM (alloxan, 45 mg/kg) study, groups treated with chamomile extract optimize the healing of traumatic oral ulcers in diabetic rats through the reduction of apoptosis in the regulated immune system.
The review of skin wound healing of phytomedicine, Dr. Pazyar N, the lead author said, " The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling" and " Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing.....(included chamomile".
The Roskilde Universitet, in the support of the wound healing effect of chamomile suggested the extract of M. chamomilla administered topically has wound healing potential in the linear incisional wound, according to an animal study.
Other studies also showed that chamomile proved effective in the treatment of oral mucositis in a hamster model.
Taking all together, chamomile no doubt has consisted of significant wound healing effects by exhibited the increased wound-breaking strength, protein collage content through topical administration.
However, well-designed clinical studies are needed to confirm the clinical efficacy of this medicine in humans.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile). by Kazemian H, Ghafourian S, Sadeghifard N, Badakhsh B, Heidari H1, Taji A, Shavalipour A, Mohebi R, Ebrahim-Saraie HS, Houri H, Houshmandfar R.(PubMed)
(2) TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats by Oliveira BV1, Barros Silva PG1, Nojosa Jde S2, Brizeno LA3, Ferreira JM4, Sousa FB1, Mota MR1, Alves AP1.(PubMed)
(3) Skin wound healing and phytomedicine: a review by Pazyar N1, Yaghoobi R, Rafiee E, Mehrabian A, Feily A.(PubMed)
(4) Evaluation of topical Matricaria chamomilla extract activity on linear incisional wound healing in albino rats by Jarrahi M1, Vafaei AA, Taherian AA, Miladi H, Rashidi Pour A.(PubMed)
(5) Healing action of topical chamomile on 5-fluoracil induced oral mucositis in hamster by Pavesi VC1, Lopez TC, Martins MA, Sant'Ana Filho M, Bussadori SK, Fernandes KP, Mesquita-Ferrari RA, Martins MD.(PubMed)
According to the Shiraz University of Medical Sciences, C. nobile therapy at 5% C. nobile ointment was an effective antibacterial activity and accelerated the progression of wound healing, in vivo.
Chamomile is also known as camomile, common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Wound healing is a natural stage of recover of body injure.
In a Wistar male rats (210.0±4.2 g) divided into five groups: negative control group (NCG) without diabetes; positive control group (PCG) with DM (alloxan, 45 mg/kg) study, groups treated with chamomile extract optimize the healing of traumatic oral ulcers in diabetic rats through the reduction of apoptosis in the regulated immune system.
The review of skin wound healing of phytomedicine, Dr. Pazyar N, the lead author said, " The healing process proceeds in four phases: hemostasis, inflammation, proliferation and remodeling" and " Phytomedicine presents remedies, which possess significant pharmacological effects. It is popular amongst the general population in regions all over the world. Phytotherapeutic agents have been largely used for cutaneous wound healing.....(included chamomile".
The Roskilde Universitet, in the support of the wound healing effect of chamomile suggested the extract of M. chamomilla administered topically has wound healing potential in the linear incisional wound, according to an animal study.
Other studies also showed that chamomile proved effective in the treatment of oral mucositis in a hamster model.
Taking all together, chamomile no doubt has consisted of significant wound healing effects by exhibited the increased wound-breaking strength, protein collage content through topical administration.
However, well-designed clinical studies are needed to confirm the clinical efficacy of this medicine in humans.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) In vivo antibacterial and wound healing activities of Roman chamomile (Chamaemelum nobile). by Kazemian H, Ghafourian S, Sadeghifard N, Badakhsh B, Heidari H1, Taji A, Shavalipour A, Mohebi R, Ebrahim-Saraie HS, Houri H, Houshmandfar R.(PubMed)
(2) TNF-alpha expression, evaluation of collagen, and TUNEL of Matricaria recutita L. extract and triamcinolone on oral ulcer in diabetic rats by Oliveira BV1, Barros Silva PG1, Nojosa Jde S2, Brizeno LA3, Ferreira JM4, Sousa FB1, Mota MR1, Alves AP1.(PubMed)
(3) Skin wound healing and phytomedicine: a review by Pazyar N1, Yaghoobi R, Rafiee E, Mehrabian A, Feily A.(PubMed)
(4) Evaluation of topical Matricaria chamomilla extract activity on linear incisional wound healing in albino rats by Jarrahi M1, Vafaei AA, Taherian AA, Miladi H, Rashidi Pour A.(PubMed)
(5) Healing action of topical chamomile on 5-fluoracil induced oral mucositis in hamster by Pavesi VC1, Lopez TC, Martins MA, Sant'Ana Filho M, Bussadori SK, Fernandes KP, Mesquita-Ferrari RA, Martins MD.(PubMed)
Sunday, May 31, 2020
Green Tea (-)-Epigallocatechin-3-gallate (EGCG), The Potential Lewy Body Disease Inhibitor, Scientists Discover
Green tea may have a potential effect in the regulation of Lewy bodies against the onset of Lewy body disease, some scientists suggested.
Lewy body disease is one of a common form of neurodegenerative diseases occurring in the elderly characterized by mutation of the Lewy bodies as a result of the abnormal structure of Lewy bodies, building up in areas of the brain.
Lewy bodies, mainly composed of α-synuclein (αS), are pathological hallmarks of Parkinson's disease and dementia with Lewy bodies.
People with building up of Lewy body in most cases also have Alzheimer's disease, causing reduced mental ability, including symptoms of visual hallucinations, and changes in alertness and attention.
Some patients with the condition are also experiencing symptoms of rigid muscles, slow movement, and tremors, the hallmarks of Parkinson's disease.
Researchers do not know why the elderly with the same health conditions and family history, some are susceptible to the early onset of the disease while others do not. However, they do know that certain risk factors such as old age, family history, and male gender are associated with the onset of Lewy body disease.
Some researchers also believe due to the severity of brain damage, patients with the condition also express certain mental instability including aggressive behavior, depression and worsening of parkinsonian-like symptoms.
A genetic alternation such as SNCA or SNCB gene mutations is also found in patients with the disease.
According to the My Virtual Medical Center, Lewy bodies is the third most frequent cause of dementia in older adults and accounts for 15–35% of all dementias
Green tea, a precious drink processes number of health benefits known to almost everyone in Asia and the Western world.
In the study of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- and 6-hydroxydopamine-induced neurodegeneration in rodents and nonhuman primates with the increased presence of iron and alpha-synuclein in the SNpc, researchers found that application of green tea catechin polyphenol (-)-epigallocatechin-3-gallate exerts a significant effect as an iron chelator in protecting the brain against neurotoxins by inhibiting the increased presence of iron and alpha-synuclein in the SNpc.
Pretreatment of green tea on N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- and 6-hydroxydopamine-induced neurodegeneration in rodents was also found to demonstrate the high levels of antioxidant activity in preventing the accumulation of iron and alpha-synuclein in SNpc.
Dr. Mandel S, the lead author suggested that a combination of iron chelation and antioxidant therapy might be a significant approach to neuroprotection in PD and other neurodegenerative diseases, including Lewy body disease.
Furthermore, in the concerns of the primary α-synucleinopathgenic expression in patients with Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, researchers at the Lanzhou University, launched an investigation to examine whether green tea (-)-Epigallocatechin-3-gallate (EGCG) can inhibit the fibrillation of αS.
After taking into account co and confounders, researchers showed that
* EGCG displays a potential effect in remodeling the αS fibrils and breaking the initially ordered pattern by reducing the β-sheet content.
* EGCG can also break the Greek confirmation of αS by the disappeared H-bond in the secondary structure of turn.
Dr. Liu X, the lead author at the end of the study said, "The results from our study can not only reveal the specific interaction between EGCG and β-sheet-rich fibrils of αS, but also provide useful guidance for the discovery of other potential inhibitors".
In other words, green tea EGCG may be considered a primary target for extracting the pharmaceutical inhibitor for the treatment of Lewy body disease.
Moreover, in the differentiation of the EGCG effect in patients with Lewy body disease, researchers at the Kanazawa University Graduate School of Medical Science conducted an evaluation to examine
EGCG effect on the transient 'active' oligomers (AOs),
At the final report, researchers found that
* EGCG facilitates the fibril formation and thus eliminating the toxic AOs.
* Also, EGCG suppresses the membrane disrupting radiating amyloid fibril formation on the surface of liposomal membranes, thus protecting the cells against the initiation of AOs.
Dr. Yang JE, the lead wrote in the summary," EGCG has been suggested to exhibit its protective effect against the αS-mediated cytotoxicity by not only producing the off-pathway 'compact' oligomers but also facilitating the conversion of 'active' oligomers into amyloid fibrils".
Taken altogether, green tea and its bioactive compound EGCG may have a potential effect in treating Lewy body disease by preventing the overexpression of α-synuclein (αS) accumulation in the brain by either inhibiting the oligomers or converting the oligomers into amyloid fibrils.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate by Mandel S1, Maor G, Youdim MB. (PubMed)
(2) EGCG-mediated Protection of the Membrane Disruption and Cytotoxicity Caused by the 'Active Oligomer' of α-Synuclein by Yang JE1, Rhoo KY2, Lee S1, Lee JT1, Park JH1, Bhak G1, Paik SR(PubMed)
(3) Influence of EGCG on α-synuclein (αS) aggregation and identification of their possible binding mode: A computational study using molecular dynamics simulation by Liu X1, Zhou S1,2, Shi D1, Bai Q1, Liu H2, Yao X1.(PubMed)
(4) Alpha-synuclein biology in Lewy body diseases by Woojin Scott Kim, Katarina Kågedal and Glenda Halliday (Research Gate)
Lewy body disease is one of a common form of neurodegenerative diseases occurring in the elderly characterized by mutation of the Lewy bodies as a result of the abnormal structure of Lewy bodies, building up in areas of the brain.
Lewy bodies, mainly composed of α-synuclein (αS), are pathological hallmarks of Parkinson's disease and dementia with Lewy bodies.
People with building up of Lewy body in most cases also have Alzheimer's disease, causing reduced mental ability, including symptoms of visual hallucinations, and changes in alertness and attention.
Some patients with the condition are also experiencing symptoms of rigid muscles, slow movement, and tremors, the hallmarks of Parkinson's disease.
Researchers do not know why the elderly with the same health conditions and family history, some are susceptible to the early onset of the disease while others do not. However, they do know that certain risk factors such as old age, family history, and male gender are associated with the onset of Lewy body disease.
Some researchers also believe due to the severity of brain damage, patients with the condition also express certain mental instability including aggressive behavior, depression and worsening of parkinsonian-like symptoms.
A genetic alternation such as SNCA or SNCB gene mutations is also found in patients with the disease.
According to the My Virtual Medical Center, Lewy bodies is the third most frequent cause of dementia in older adults and accounts for 15–35% of all dementias
Green tea, a precious drink processes number of health benefits known to almost everyone in Asia and the Western world.
In the study of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- and 6-hydroxydopamine-induced neurodegeneration in rodents and nonhuman primates with the increased presence of iron and alpha-synuclein in the SNpc, researchers found that application of green tea catechin polyphenol (-)-epigallocatechin-3-gallate exerts a significant effect as an iron chelator in protecting the brain against neurotoxins by inhibiting the increased presence of iron and alpha-synuclein in the SNpc.
Pretreatment of green tea on N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- and 6-hydroxydopamine-induced neurodegeneration in rodents was also found to demonstrate the high levels of antioxidant activity in preventing the accumulation of iron and alpha-synuclein in SNpc.
Dr. Mandel S, the lead author suggested that a combination of iron chelation and antioxidant therapy might be a significant approach to neuroprotection in PD and other neurodegenerative diseases, including Lewy body disease.
Furthermore, in the concerns of the primary α-synucleinopathgenic expression in patients with Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, researchers at the Lanzhou University, launched an investigation to examine whether green tea (-)-Epigallocatechin-3-gallate (EGCG) can inhibit the fibrillation of αS.
After taking into account co and confounders, researchers showed that
* EGCG displays a potential effect in remodeling the αS fibrils and breaking the initially ordered pattern by reducing the β-sheet content.
* EGCG can also break the Greek confirmation of αS by the disappeared H-bond in the secondary structure of turn.
Dr. Liu X, the lead author at the end of the study said, "The results from our study can not only reveal the specific interaction between EGCG and β-sheet-rich fibrils of αS, but also provide useful guidance for the discovery of other potential inhibitors".
In other words, green tea EGCG may be considered a primary target for extracting the pharmaceutical inhibitor for the treatment of Lewy body disease.
Moreover, in the differentiation of the EGCG effect in patients with Lewy body disease, researchers at the Kanazawa University Graduate School of Medical Science conducted an evaluation to examine
EGCG effect on the transient 'active' oligomers (AOs),
At the final report, researchers found that
* EGCG facilitates the fibril formation and thus eliminating the toxic AOs.
* Also, EGCG suppresses the membrane disrupting radiating amyloid fibril formation on the surface of liposomal membranes, thus protecting the cells against the initiation of AOs.
Dr. Yang JE, the lead wrote in the summary," EGCG has been suggested to exhibit its protective effect against the αS-mediated cytotoxicity by not only producing the off-pathway 'compact' oligomers but also facilitating the conversion of 'active' oligomers into amyloid fibrils".
Taken altogether, green tea and its bioactive compound EGCG may have a potential effect in treating Lewy body disease by preventing the overexpression of α-synuclein (αS) accumulation in the brain by either inhibiting the oligomers or converting the oligomers into amyloid fibrils.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate by Mandel S1, Maor G, Youdim MB. (PubMed)
(2) EGCG-mediated Protection of the Membrane Disruption and Cytotoxicity Caused by the 'Active Oligomer' of α-Synuclein by Yang JE1, Rhoo KY2, Lee S1, Lee JT1, Park JH1, Bhak G1, Paik SR(PubMed)
(3) Influence of EGCG on α-synuclein (αS) aggregation and identification of their possible binding mode: A computational study using molecular dynamics simulation by Liu X1, Zhou S1,2, Shi D1, Bai Q1, Liu H2, Yao X1.(PubMed)
(4) Alpha-synuclein biology in Lewy body diseases by Woojin Scott Kim, Katarina Kågedal and Glenda Halliday (Research Gate)
Saturday, May 30, 2020
Healthy Food Cranberry, the Natural Anti-Inflammatory Remedy
Inflammation is a process of the immune system that responds to harmful pathogens.
Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
However, in some cases, the overproduction of proinflammatory cytokines may damage nearby healthy cells and tissues, causing the formation of scars.
In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal condition also switch to produce pro-inflammatory cytokines.
Most cases of acute inflammatory are resolved within a few days without causing damage to the wound tissues. However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.
Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.
Dr. Duprez DA, the lead scientist at the University of Minnesota.in the investigation of inflammatory makers and chronic inflammation wrote, "Numerous studies have shown that high-sensitivity C-reactive protein (hsCRP), one of the most frequently studied inflammatory markers, is associated with the chronic inflammatory-related disease, cardiovascular disease, cancer and mortality [1]. While hs-CRP is a single marker of inflammation".
In other words, if you have a chronic inflammatory disease, your levels of hsCRP are much high compared to people who do not.
Conventionally, treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diseases associated with inflammation, researchers examined the effect of the effects of freeze-dried cranberry powder on anti-inflammation and lipid profiles.
The study included a total of 40 Sprague-Dawley male rats (6-weeks-old) were equally divided into the following five groups: 1) normal diet group + saline (NC); 2) atherogenic diet + saline (HFC); 3) atherogenic diet + LPS (HL); 4) atherogenic diet with 5% cranberry power + LPS (C5); 5) atherogenic diet with 10% cranberry power + LPS (C10).
Based on the analysis after LPS (0.5 mg/kg) was injected into the abdominal cavities of rats 18 hours prior to sacrifice, researchers found that* C5 rats treated by atherogenic diet with 5% cranberry power + LPS showed a mean serum high-density lipoprotein (HDL)-cholesterol level in C5 rats was significantly higher compared to those in NC and HL rats.
* The mean serum levels of CRP and IL-1β associated with pro-inflammatory marker and expression were significantly lower (P < 0.05) in the cranberry powder groups compared to HL rats.
* Furthermore, levels of anti-inflammatory cytokines expressed by the serum IL-10 and NO showed 29% and 88% higher mean values in the C5 group and 49% and 24% higher in the C10 group than those in the HL group, respectively.
In other words, cranberry powder protects the Sprague-Dawley male rats induced inflammation by elevating the levels of anti-inflammatory and lowering the levels of pro-inflammatory cytokines.
Collectively, researchers wrote, " freeze-dried cranberry powder may have beneficial effects on cardiovascular diseases by modifying serum lipids and the early inflammatory response."
Taken altogether, cranberry may be considered an anti-inflammatory remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet by Kim MJ1, Ohn J, Kim JH, Kwak HK. (PubMed)
(2) GlycA, a composite low-grade inflammatory marker, predicts mortality: prime time for utilization? by Duprez DA1, Jacobs DR Jr. (PubMed)
Inflammation can be acute or chronic. In the acute phase of infection, the immune system after receiving information from the neurons, macrophages, the largest white blood cells in the first line of defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
However, in some cases, the overproduction of proinflammatory cytokines may damage nearby healthy cells and tissues, causing the formation of scars.
In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal condition also switch to produce pro-inflammatory cytokines.
Most cases of acute inflammatory are resolved within a few days without causing damage to the wound tissues. However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.
Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.
Dr. Duprez DA, the lead scientist at the University of Minnesota.in the investigation of inflammatory makers and chronic inflammation wrote, "Numerous studies have shown that high-sensitivity C-reactive protein (hsCRP), one of the most frequently studied inflammatory markers, is associated with the chronic inflammatory-related disease, cardiovascular disease, cancer and mortality [1]. While hs-CRP is a single marker of inflammation".
In other words, if you have a chronic inflammatory disease, your levels of hsCRP are much high compared to people who do not.
Conventionally, treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diseases associated with inflammation, researchers examined the effect of the effects of freeze-dried cranberry powder on anti-inflammation and lipid profiles.
The study included a total of 40 Sprague-Dawley male rats (6-weeks-old) were equally divided into the following five groups: 1) normal diet group + saline (NC); 2) atherogenic diet + saline (HFC); 3) atherogenic diet + LPS (HL); 4) atherogenic diet with 5% cranberry power + LPS (C5); 5) atherogenic diet with 10% cranberry power + LPS (C10).
Based on the analysis after LPS (0.5 mg/kg) was injected into the abdominal cavities of rats 18 hours prior to sacrifice, researchers found that* C5 rats treated by atherogenic diet with 5% cranberry power + LPS showed a mean serum high-density lipoprotein (HDL)-cholesterol level in C5 rats was significantly higher compared to those in NC and HL rats.
* The mean serum levels of CRP and IL-1β associated with pro-inflammatory marker and expression were significantly lower (P < 0.05) in the cranberry powder groups compared to HL rats.
* Furthermore, levels of anti-inflammatory cytokines expressed by the serum IL-10 and NO showed 29% and 88% higher mean values in the C5 group and 49% and 24% higher in the C10 group than those in the HL group, respectively.
In other words, cranberry powder protects the Sprague-Dawley male rats induced inflammation by elevating the levels of anti-inflammatory and lowering the levels of pro-inflammatory cytokines.
Collectively, researchers wrote, " freeze-dried cranberry powder may have beneficial effects on cardiovascular diseases by modifying serum lipids and the early inflammatory response."
Taken altogether, cranberry may be considered an anti-inflammatory remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet by Kim MJ1, Ohn J, Kim JH, Kwak HK. (PubMed)
(2) GlycA, a composite low-grade inflammatory marker, predicts mortality: prime time for utilization? by Duprez DA1, Jacobs DR Jr. (PubMed)
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