Scientists may have found a bioactive ingredient that protects the endocrine system integrity with no side effects, according to studies.
The endocrine system is made up of glands that produce and secrete hormones with an aim to regulate the activity of cells or organs.
In other words, the endocrine system produces hormones to regulate the body's growth, metabolism (the physical and chemical processes of the body), and sexual development and function.
Any disruption of the endocrine system can cause abnormal production of the hormones, leading to developmental malformations in the infant and children, interference with the function of the reproductive organ, increased cancer risk; and disturbances in the immune and nervous system function.
The most common cause of endocrine dysfunction is exposure to men-make xenochemiclas. Particularly to those new and without testing men make chemicals introduced to the market every year.
There are many ways that endocrine disruptors can interfere with the endocrine system in hormone production such as mimic or partly mimic naturally occurring hormones in the body like estrogens such as xanophytochemicals that bind to a receptor within a cell and block the endogenous hormone from binding.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural ingredient that promotes the endocrine function, researchers examined the effects of ginger and turmeric on the modulation of hormone production of the body glands.
According to the differentiation of physiological and therapeutic effects of ginger and turmeric, both exerted a significant activity in some endocrine gland functions, and signal pathways by
* Inhibiting the high levels of some hormones such as T4, leptin or interacting with hormone receptors. In other words, ginger and turmeric normalize the levels of the hormone for the body needs.
* Inhibiting the production of cytokines/adipokine expression associated with inflammation and oxidative stress.
* Inhibiting the levels of reactive oxygen species (ROS)-generating enzymes against the oxidative stress-induced hormone imbalance.
* Protecting the cell integrity against DNA alternation by promoting pro-apoptotic and inhibiting proliferative genes.
The results strongly suggested that ginger and curcumin exerted strong protection of endocrine functioning by modulating the hormones produced by the glands.
Based on the findings, researchers said, "These multiple mechanisms of protection against inflammation and oxidative damage make ginger and curcumin particularly promising natural agents in fighting the ravages of aging and degenerative diseases".
Taken altogether, turmeric combined with ginger may be considered supplements for the prevention and treatment of endocrine dysfunction, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Physiological and therapeutical roles of ginger and turmeric on endocrine functions by Al-Suhaimi EA1, Al-Riziza NA, Al-Essa RA. (PubMed)
(2) [Effect of 5 warm-hot nature Chinese drugs for promoting blood circulation and removing blood stasis on 5-HT, NE, and endocrine hormones of rats of cold coagulation and blood stasis syndrome].[Article in Chinese] by Wang P1, Fu XJ, Zhou Y, Wang ZG. (PubMed)
Friday, June 12, 2020
Thursday, June 11, 2020
Herbal Bilberry Protects the Blood Vessels Against the Risk of Vascular Disease in Vivo
Vasoprotection is the action in which substances including herbal and natural remedy are used to protect the integrity of the blood vessels.
Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.
There are 3 main types of blood vessel
* Arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries is found to induce coronary artery disease caused by narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.
* Veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with disease of the veins that affects up to 20 percent of adults.
* Capillaries (the smallest blood vessels) has been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Some researchers suggested that following a healthy diet accompanied by moderate exercise may have a strong impact on the blood vessels' integrity.
Dr. Hanrui Zhang said, "Accumulating evidence suggests that inflammatory cytokine tumor necrosis factor-alpha (TNFα) plays a pivotal role in the dysregulation of macrovascular and microvascular function".
And, "Dietary supplements and exercise training decrease TNFαproduction and ameliorate TNFα-mediated pathological changes in vasculature. Thus, the inhibitory effects of dietary supplements and physical exercise on TNFα production and TNFα signaling may contribute to their vasoprotective properties".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding a natural ingredient which processes vasoactive and vasoprotective properties, researchers examined the effects of anthocyanin-rich extracts prepared from chokeberry (Ck), bilberry (B), or elderberry (E). on reactive oxygen species (ROS) play a critical role in the impairment of nitric oxide-mediated vascular functions.
In Coronary arterial rings isolated from 64 pigs and incubated in sterile tissue culture media overnight, Ck and B, but not E, produced dose- and endothelium-dependent vasorelaxation.
In coronary vascular tone, endothelium-dependent vasorelaxation by other factors was not affected by exposure of rings to any extract at 0.05 mg total anthocyanins per liter for 5 or 30 min.
Furthermore, anthocyanin-enhanced extracts produce endothelium-dependent relaxation in porcine coronary arteries.
However, high doses of B exerted a significantly protective effect against alternation of coronary arteries induced by ROS with no effect on vasorelaxation to endogenous or exogenous NO.
Based on the findings, researchers wrote, "These results suggest that such extracts could have significant beneficial effects in vascular disease".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the prevention and treatment of vascular disease, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts by Bell DR1, Gochenaur K. (PubMed)
(2) Vasoprotection by Dietary Supplements and Exercise: Role of TNFα Signaling by Hanrui Zhang* and Cuihua Zhang. (PMC)
Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.
There are 3 main types of blood vessel
* Arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries is found to induce coronary artery disease caused by narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.
* Veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with disease of the veins that affects up to 20 percent of adults.
* Capillaries (the smallest blood vessels) has been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Some researchers suggested that following a healthy diet accompanied by moderate exercise may have a strong impact on the blood vessels' integrity.
Dr. Hanrui Zhang said, "Accumulating evidence suggests that inflammatory cytokine tumor necrosis factor-alpha (TNFα) plays a pivotal role in the dysregulation of macrovascular and microvascular function".
And, "Dietary supplements and exercise training decrease TNFαproduction and ameliorate TNFα-mediated pathological changes in vasculature. Thus, the inhibitory effects of dietary supplements and physical exercise on TNFα production and TNFα signaling may contribute to their vasoprotective properties".
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
On finding a natural ingredient which processes vasoactive and vasoprotective properties, researchers examined the effects of anthocyanin-rich extracts prepared from chokeberry (Ck), bilberry (B), or elderberry (E). on reactive oxygen species (ROS) play a critical role in the impairment of nitric oxide-mediated vascular functions.
In Coronary arterial rings isolated from 64 pigs and incubated in sterile tissue culture media overnight, Ck and B, but not E, produced dose- and endothelium-dependent vasorelaxation.
In coronary vascular tone, endothelium-dependent vasorelaxation by other factors was not affected by exposure of rings to any extract at 0.05 mg total anthocyanins per liter for 5 or 30 min.
Furthermore, anthocyanin-enhanced extracts produce endothelium-dependent relaxation in porcine coronary arteries.
However, high doses of B exerted a significantly protective effect against alternation of coronary arteries induced by ROS with no effect on vasorelaxation to endogenous or exogenous NO.
Based on the findings, researchers wrote, "These results suggest that such extracts could have significant beneficial effects in vascular disease".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the prevention and treatment of vascular disease, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts by Bell DR1, Gochenaur K. (PubMed)
(2) Vasoprotection by Dietary Supplements and Exercise: Role of TNFα Signaling by Hanrui Zhang* and Cuihua Zhang. (PMC)
Wednesday, June 10, 2020
Bromelain, the Natural Anti Blood Coagulation Remedy
Coagulation is the process to form a blood clot. Coagulation is also used by the immune system to cover the wound or cut to prevent additional blood loss and protect the body against the invasion of foreign microorganisms.
More precisely, in the acute phase of infection, the immune system activated the fibrins together with small blood cell fragments called platelets, to form the clot. The clots are removed after healing.
However, excessive blood clotting associated with certain diseases and conditions, genetic mutations, and medicines, particularly in the aging population has been found to increase the risk of cardiovascular disease.
Excessive blood clotting can be classified into acquired and genetic excessive blood clotting
* Risk factors associated with acquired excessive blood clotting are smoking, overweight, and obesity, pregnancy, use of birth control pills or hormone replacement therapy,...
* The genetic preposition of clotting occurs in the mutation of proteins associated with blood clotting including mutated proteins that cause delay or dissolve blood clots such as Factor V Leiden and
Prothrombin gene mutation.
The most common diseases associated with excessive blood clotting include venous thromboembolism or DVT that involve in the deep veins in the legs and arterial thrombosis that involves in the arteries of the heart.
Conventionally, most cases of excessive blood clotting are treated by anticoagulants. In life-threatening blood clots, thrombolytics can dissolve clots that are already formed.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of blood coagulation, researchers examined the bromelain coagulation-inhibiting effects.
In an animal model, bromelain enhanced the activity of serum fibrinolysis by inhibiting the fibrinogen synthesis involving in hepatocytes in the final stages of the blood coagulation process.
Additionally, the anti-blood coagulative activity also exhibits the direct degradation of fibrin and fibrinogen associated with the clotting of blood.
Furthermore, bromelain lowers kininogen and bradykinin serum that involve in the contact activation of the blood coagulation process.
Additionally, bromelain also influenced on prostaglandin synthesis that serves the physiological function of preventing needless clot formation.
Moreover, these effects of bromelain are also dose-dependent.
Taken altogether, bromelain may be considered a remedy for the prevention and treatment of blood coagulation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
More precisely, in the acute phase of infection, the immune system activated the fibrins together with small blood cell fragments called platelets, to form the clot. The clots are removed after healing.
However, excessive blood clotting associated with certain diseases and conditions, genetic mutations, and medicines, particularly in the aging population has been found to increase the risk of cardiovascular disease.
Excessive blood clotting can be classified into acquired and genetic excessive blood clotting
* Risk factors associated with acquired excessive blood clotting are smoking, overweight, and obesity, pregnancy, use of birth control pills or hormone replacement therapy,...
* The genetic preposition of clotting occurs in the mutation of proteins associated with blood clotting including mutated proteins that cause delay or dissolve blood clots such as Factor V Leiden and
Prothrombin gene mutation.
The most common diseases associated with excessive blood clotting include venous thromboembolism or DVT that involve in the deep veins in the legs and arterial thrombosis that involves in the arteries of the heart.
Conventionally, most cases of excessive blood clotting are treated by anticoagulants. In life-threatening blood clots, thrombolytics can dissolve clots that are already formed.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of blood coagulation, researchers examined the bromelain coagulation-inhibiting effects.
In an animal model, bromelain enhanced the activity of serum fibrinolysis by inhibiting the fibrinogen synthesis involving in hepatocytes in the final stages of the blood coagulation process.
Additionally, the anti-blood coagulative activity also exhibits the direct degradation of fibrin and fibrinogen associated with the clotting of blood.
Furthermore, bromelain lowers kininogen and bradykinin serum that involve in the contact activation of the blood coagulation process.
Additionally, bromelain also influenced on prostaglandin synthesis that serves the physiological function of preventing needless clot formation.
Moreover, these effects of bromelain are also dose-dependent.
Taken altogether, bromelain may be considered a remedy for the prevention and treatment of blood coagulation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
Tuesday, June 9, 2020
Topical Turmeric, the Best for the Prevention and Treatment Vitiligo
Vitiligo is a condition of skin discolor disease caused by the destruction of pigment cells and melanocytes of the skin.
The condition, in most cases is localized. However, in some patients, the disease also can affect several different areas on the body.
Symptoms of vitiligo are associated with the loss of skin color, or white, and patches of skin.
The exact cause of vitiligo is unknown, however, some researchers suggested that the disease may be caused by the immune overreaction that mistakenly attacks and destroys certain cells within the body.
Epidemiologically, people in the younger age group before the age of 40 are at most risk of vitiligo.
According to the statistics, over 50% of vitiligo is found in patients who are 20 and younger.
The condition has been found to induce emotional and psychological issues to patients, even the condition does not cause pain or health problems.
As of today, researchers do not know how to prevent disease onset. Most medications for the treatment of vitiligo including creams that control inflammation, combining psoralen and light therapy are focusing on reducing the severity of the condition and improve the quality of life.
If all noninvasive treatments fail, surgery may be necessary.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of vitiligo, researchers examined the curcumin effect on the pigment cells of the skin, melanocytes.
Injection of Cucumis melo extract showed to exhibit the production of antioxidants by the host in blocking the effect of free radicals in the induction of skin oxidative stress.
Topical preparation, containing Cucumis melo superoxide dismutase (SOD) and catalase, demonstrated a potential effect in the treatment of vitiligo.
Natural UV or artificial narrowband UVB treatment or phototherapy displayed significant protection against pigment damage, similar to those of turmeric topical preparation.
Additionally, the topical gel according to the repigmentation rate recorded exerted a similar effect compared to the patients treated only with phototherapy with adverse effects.
Moreover, the topical formulation, containing phenylalanine, Cucumis melo extract, and acetylcysteine showed a more promising result combined with nb - UVB target phototherapy.
Based on the findings, turmeric used along with or combined with other conventional medicine may be considered remedies for the prevention and treatment of vitiligo pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Herbal Compounds for the Treatment of Vitiligo: A Review by Serena Gianfaldoni,1,* Uwe Wollina,2 Michael Tirant,3 Georgi Tchernev,4 Jacopo Lotti,5Francesca Satolli,6 Miriam Rovesti,6 Katlein França,7 and Torello Lotti. (PMC)
The condition, in most cases is localized. However, in some patients, the disease also can affect several different areas on the body.
Symptoms of vitiligo are associated with the loss of skin color, or white, and patches of skin.
The exact cause of vitiligo is unknown, however, some researchers suggested that the disease may be caused by the immune overreaction that mistakenly attacks and destroys certain cells within the body.
Epidemiologically, people in the younger age group before the age of 40 are at most risk of vitiligo.
According to the statistics, over 50% of vitiligo is found in patients who are 20 and younger.
The condition has been found to induce emotional and psychological issues to patients, even the condition does not cause pain or health problems.
As of today, researchers do not know how to prevent disease onset. Most medications for the treatment of vitiligo including creams that control inflammation, combining psoralen and light therapy are focusing on reducing the severity of the condition and improve the quality of life.
If all noninvasive treatments fail, surgery may be necessary.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of vitiligo, researchers examined the curcumin effect on the pigment cells of the skin, melanocytes.
Injection of Cucumis melo extract showed to exhibit the production of antioxidants by the host in blocking the effect of free radicals in the induction of skin oxidative stress.
Topical preparation, containing Cucumis melo superoxide dismutase (SOD) and catalase, demonstrated a potential effect in the treatment of vitiligo.
Natural UV or artificial narrowband UVB treatment or phototherapy displayed significant protection against pigment damage, similar to those of turmeric topical preparation.
Additionally, the topical gel according to the repigmentation rate recorded exerted a similar effect compared to the patients treated only with phototherapy with adverse effects.
Moreover, the topical formulation, containing phenylalanine, Cucumis melo extract, and acetylcysteine showed a more promising result combined with nb - UVB target phototherapy.
Based on the findings, turmeric used along with or combined with other conventional medicine may be considered remedies for the prevention and treatment of vitiligo pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Herbal Compounds for the Treatment of Vitiligo: A Review by Serena Gianfaldoni,1,* Uwe Wollina,2 Michael Tirant,3 Georgi Tchernev,4 Jacopo Lotti,5Francesca Satolli,6 Miriam Rovesti,6 Katlein França,7 and Torello Lotti. (PMC)
Monday, June 8, 2020
Herbal Turmeric Enhances the Ratio of Human Gut Microbiota
Gut microbiota is a community of microbes living in the gastrointestinal tract.
Believe it or not, there are over trillions of microorganisms, including at least 1000 different species of known bacteria with more than 3 million genes.
In a healthy individual, the ratio of good and bad microbes in the gut are balanced. However, people who are under constant stress or have a psychological condition such as anxiety, and depression, and long-term use of antibiotics may have a negative impact on the ratio.
In other words, emotional problems, use of antibiotics may alter the ratio of the microbes in the gut, leading to inflammation, oxidative stress, and blood sugar imbalances.
Dr. Ruth K. Dudek-Wicher, the lead scientists wrote, "Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders".
And, "...the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp.".
More precisely, imbalanced gut community microbes ratio can induce certain health problems including
* Decreasing the interaction with the immune function against inflammatory immune disorders.
* Increasing the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
* Reducing nutrient extraction from the diet, thus increasing the risk of obesity and obese complication.
* Failure to control brain insulin signaling and metabolite levels that can lead to bad neurobehaviors.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the improvement of bacterial composition in the gut, researchers
examined the effects of curcumin in the gut microbiota in dysbiosis, a condition that links to many metabolic diseases.
According to the tested assays, curcumin and its derivatives exerted direct regulative effects on the gut microbiota by increasing the ratio of bacteria composition in the flavor of good bacterias.
Furthermore, in the testing the turmeric tablets in the gut microbiota determined by 16S rDNA sequencing, researchers divided.14 healthy human subjects into 3 groups with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3).
According to the bacterial analysis, turmeric-treated subjects displayed a modest 7% increase in observed species compared to control with an overall reduction in species by 15%.
Moreover, curcumin displayed an average increase of 69% in detected species, depending on the gut microbiota response to individual subjects.
More precisely, in "responsive" subjects curcumin increased in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. and reduced relative abundance of several Blautia spp. and most Ruminococcus spp.
In other words, curcumin improved the ratio of gut microbiota by stimulating the production of "good bacterial and reducing the levels of "bad" bacterias in the colon.
Based on the findings, researchers wrote, "All participants' microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner".
Taken altogether, turmeric may be considered supplements for the prevention and treatment of imbalanced ratio of gut microbiome composition, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence by Zam W. (PubMed)
(2) Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study by Peterson CT1, Vaughn AR2,3, Sharma V4, Chopra D1,5, Mills PJ1, Peterson SN4, Sivamani RK. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher,
Adam Junka, and Marzenna Bartoszewicz. (PMC)
Believe it or not, there are over trillions of microorganisms, including at least 1000 different species of known bacteria with more than 3 million genes.
In a healthy individual, the ratio of good and bad microbes in the gut are balanced. However, people who are under constant stress or have a psychological condition such as anxiety, and depression, and long-term use of antibiotics may have a negative impact on the ratio.
In other words, emotional problems, use of antibiotics may alter the ratio of the microbes in the gut, leading to inflammation, oxidative stress, and blood sugar imbalances.
Dr. Ruth K. Dudek-Wicher, the lead scientists wrote, "Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders".
And, "...the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp.".
More precisely, imbalanced gut community microbes ratio can induce certain health problems including
* Decreasing the interaction with the immune function against inflammatory immune disorders.
* Increasing the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
* Reducing nutrient extraction from the diet, thus increasing the risk of obesity and obese complication.
* Failure to control brain insulin signaling and metabolite levels that can lead to bad neurobehaviors.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the improvement of bacterial composition in the gut, researchers
examined the effects of curcumin in the gut microbiota in dysbiosis, a condition that links to many metabolic diseases.
According to the tested assays, curcumin and its derivatives exerted direct regulative effects on the gut microbiota by increasing the ratio of bacteria composition in the flavor of good bacterias.
Furthermore, in the testing the turmeric tablets in the gut microbiota determined by 16S rDNA sequencing, researchers divided.14 healthy human subjects into 3 groups with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3).
According to the bacterial analysis, turmeric-treated subjects displayed a modest 7% increase in observed species compared to control with an overall reduction in species by 15%.
Moreover, curcumin displayed an average increase of 69% in detected species, depending on the gut microbiota response to individual subjects.
More precisely, in "responsive" subjects curcumin increased in most Clostridium spp., Bacteroides spp., Citrobacter spp., Cronobacter spp., Enterobacter spp., Enterococcus spp., Klebsiella spp., Parabacteroides spp., and Pseudomonas spp. and reduced relative abundance of several Blautia spp. and most Ruminococcus spp.
In other words, curcumin improved the ratio of gut microbiota by stimulating the production of "good bacterial and reducing the levels of "bad" bacterias in the colon.
Based on the findings, researchers wrote, "All participants' microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner".
Taken altogether, turmeric may be considered supplements for the prevention and treatment of imbalanced ratio of gut microbiome composition, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence by Zam W. (PubMed)
(2) Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study by Peterson CT1, Vaughn AR2,3, Sharma V4, Chopra D1,5, Mills PJ1, Peterson SN4, Sivamani RK. (PubMed)
(3) The influence of antibiotics and dietary components on gut microbiota by Ruth K. Dudek-Wicher,
Adam Junka, and Marzenna Bartoszewicz. (PMC)
Sunday, June 7, 2020
Cinnamon: The Best Whole Food Medicine for Patients with Hyperlipidemia
Intake of cinnamon is found to improve levels of blood cholesterol in patients with Hyperlipidemia.
According to the Shaanxi Provincial People's Hospital, cinnamaldehyde (CA), an active and major compound in cinnamon reduced levels of triglyceride, cholesterol, low-density lipoprotein-cholesterol (LDL-C) and increased high-density lipoprotein-cholesterol (HDL-C), in C57BLKS/J db/db mice.
Cinnamon is a spice derived from the inner bark of a tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, used in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
Hyperlipidemia is abnormally elevated levels of any or all lipids or lipoproteins in the blood.
Also in C57BL/Ks db/db mice study, the cinnamon extract significantly improved hyperglycemia and hyperlipidemia possibly by regulating the protein with function in medicated glucose and lipid metabolism.
Furthermore, in rats fed a high-fat diet (HFD), oral administration of cinnamon polyphenol extract reduced the hyperlipidemia, inflammation, and oxidative stress through activating the proteins involved to transfer genetic information of DNA into RNA and antioxidative defense signaling pathway.
Dr. Ghorbani A, the lead author at a joint study said, " the levels of triglyceride and total cholesterol in polyherbal mixture treated rats were significantly lower than those in the diabetic control group (P < 0.05)" and "Our results demonstrated that this polyherbal mixture has beneficial effects on blood glucose and lipid profile and it has the potential to be used as a dietary supplement for the management of diabetes"
With all the information collected, cinnamon may have potency in reduced levels of triglycerides, LDL cholesterol, and increased HDL cholesterol in patients with hyperlipidemia, but the use of high quantity should only be given by herbalist in the prevention of toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57BLKS/J db/db mice by Li J1, Liu T, Wang L, Guo X, Xu T, Wu L, Qin L, Sun W.(PubMed)
(2) Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats by Tuzcu Z1, Orhan C2, Sahin N2, Juturu V3, Sahin K2.(PubMed)
(3) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(4) Antihyperlipidemic effect of a polyherbal mixture in streptozotocin-induced diabetic rats by Ghorbani A1, Shafiee-Nick R2, Rakhshandeh H2, Borji A3.(PubMed)
According to the Shaanxi Provincial People's Hospital, cinnamaldehyde (CA), an active and major compound in cinnamon reduced levels of triglyceride, cholesterol, low-density lipoprotein-cholesterol (LDL-C) and increased high-density lipoprotein-cholesterol (HDL-C), in C57BLKS/J db/db mice.
Cinnamon is a spice derived from the inner bark of a tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, used in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.
Hyperlipidemia is abnormally elevated levels of any or all lipids or lipoproteins in the blood.
Also in C57BL/Ks db/db mice study, the cinnamon extract significantly improved hyperglycemia and hyperlipidemia possibly by regulating the protein with function in medicated glucose and lipid metabolism.
Furthermore, in rats fed a high-fat diet (HFD), oral administration of cinnamon polyphenol extract reduced the hyperlipidemia, inflammation, and oxidative stress through activating the proteins involved to transfer genetic information of DNA into RNA and antioxidative defense signaling pathway.
Dr. Ghorbani A, the lead author at a joint study said, " the levels of triglyceride and total cholesterol in polyherbal mixture treated rats were significantly lower than those in the diabetic control group (P < 0.05)" and "Our results demonstrated that this polyherbal mixture has beneficial effects on blood glucose and lipid profile and it has the potential to be used as a dietary supplement for the management of diabetes"
With all the information collected, cinnamon may have potency in reduced levels of triglycerides, LDL cholesterol, and increased HDL cholesterol in patients with hyperlipidemia, but the use of high quantity should only be given by herbalist in the prevention of toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57BLKS/J db/db mice by Li J1, Liu T, Wang L, Guo X, Xu T, Wu L, Qin L, Sun W.(PubMed)
(2) Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats by Tuzcu Z1, Orhan C2, Sahin N2, Juturu V3, Sahin K2.(PubMed)
(3) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(4) Antihyperlipidemic effect of a polyherbal mixture in streptozotocin-induced diabetic rats by Ghorbani A1, Shafiee-Nick R2, Rakhshandeh H2, Borji A3.(PubMed)
Saturday, June 6, 2020
Cascara Sagrada (Rhamnus purshiana) and primary glioblastoma
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
Bone Cancer
Bone cancer is an abnormal growth of cells within the bone that have become cancerous. Bone cancer may be classified as primary cancer originated in the bone, and secondary cancer originated from elsewhere.
The Ingredients
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
The health benefits Aloe emodin have been found to effective in induced cell anti-proliferation and apoptosis in some cancer cell line. In U87 human malignant glioma cells, the chemical constituent found in Cascara Sagrada,
arrested the cell cycle in the synthesis phase of the cell cycle and promoted the loss of mitochondrial membrane potential in U87 cells, leading to early event of the mitochondria-induced apoptotic pathway. In other studies of dimethylsulfoxide (DMSO; control) or aloe-emodin (40 microM) showed the effect of Aloe-emodin in inducing apoptosis in U-373MG glioma cells by suppressed PKC(a family of protein) activity and reduced the protein content of most of the PKC isozymes. These results support the positive effect of aloe-emodin and may be considered as a potential agent in treating human malignant glioma cells.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin by Ismail S, Haris K, Abdul Ghani AR, Abdullah JM, Johan MF, Mohamed Yusoff AA.(PubMed)
(2) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells by Acevedo-Duncan M, Russell C, Patel S, Patel R.(PubMed)
Bone Cancer
Bone cancer is an abnormal growth of cells within the bone that have become cancerous. Bone cancer may be classified as primary cancer originated in the bone, and secondary cancer originated from elsewhere.
The Ingredients
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
The health benefits Aloe emodin have been found to effective in induced cell anti-proliferation and apoptosis in some cancer cell line. In U87 human malignant glioma cells, the chemical constituent found in Cascara Sagrada,
arrested the cell cycle in the synthesis phase of the cell cycle and promoted the loss of mitochondrial membrane potential in U87 cells, leading to early event of the mitochondria-induced apoptotic pathway. In other studies of dimethylsulfoxide (DMSO; control) or aloe-emodin (40 microM) showed the effect of Aloe-emodin in inducing apoptosis in U-373MG glioma cells by suppressed PKC(a family of protein) activity and reduced the protein content of most of the PKC isozymes. These results support the positive effect of aloe-emodin and may be considered as a potential agent in treating human malignant glioma cells.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Most common Types of Cancer http://kylejnorton.blogspot.ca/p/blog-page.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin by Ismail S, Haris K, Abdul Ghani AR, Abdullah JM, Johan MF, Mohamed Yusoff AA.(PubMed)
(2) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells by Acevedo-Duncan M, Russell C, Patel S, Patel R.(PubMed)
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