Bromelain Kills Breast Cancer Cells in Vitro

Breast cancer is a medical condition characterized by irregular cell growth in the breast tissue due to the alternation of DNA.

Most cases of breast cancer at the early stage start in the cells on the surface of the inner lining of either from the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At this stage, the patient may first notice as a painless lump in the breast or armpit and most often discovered by herself or her partner.


However, some patients may also experience symptoms of nipple discharge (clear or bloody)
inverted or retracted nipple, scaly or pitted skin on nipple persistent tenderness of the breast and
unusual breast pain or discomfort.

At the advanced stage, besides experiencing symptoms shared commonly with other types of cancer, patients may also notice localized bleeding and severe pain due to the oversize that press on nearby blood vessels and nerves.

According to the U.S. Breast Cancer Statistics, approximately, 1 in 8 U.S. women or 12% will develop invasive breast cancer over the course of their lifetime.

In 2019, an estimated 268,600 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

The 5 years survival rate of breast cancer at the early stage is close to 100%.

The causes of breast cancer are not identified. Gender, aging, genetic preposition, family history, never pregnant women, and smoking are some breast cancer prevalent risks.


Dr. Bhaskarapillai Binukuma, the lead scientist in the evaluation of the diet risk of breast cancer wrote, "Increased consumption of total fat and saturated fat were found to be positively associated with the development of breast cancer".

And, "A moderate inverse association between consumption of n-3 fatty acids and breast cancer risk and a moderate positive association between n-6 fatty acids and breast cancer risk were observed".

In other words, if you are a high-fat diet follower, your risk of breast cancer is increased substantially.


Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient for the treatment of breast cancer, researchers examined the bromelain-functionalized multiple-wall lipid-core nanocapsules (Bro-MLNC-Zn) on breast cancer cell line.

The complex used for the study was formed by a Zn-N chemical bond and a chelate with hydroxyl and carboxyl group.

In human breast cancer cells (MCF-7), the complex at the nanocapsule surface showed an antiproliferative effect by maintaining its proteolytic activity.

Interestingly, Bro-MLNC-Zn showed a reduced dose at 160-folds to exerted a similar effect compared to that of and bromelain solution.

Based on the results, researchers said, "The surface functionalization approach produced an innovative formulation having a much higher antiproliferative effect than the bromelain solution".

In order to reveal more information about bromelain anti-breast cancer activity, researchers investigated the possible synergistic cytotoxic effects of bromelain in combination with cisplatin on MDA-MB-231 human breast cancer cells.

Human MDA-MB-231 cells used in the study were treated with different concentrations (0.24-9.5 µM) of bromelain or cisplatin alone, as well as four different combinations.

According to the results of tested assays, single-agent treatment with cisplatin or bromelain decreases the viability of the MDA-MB-231 cells at 24 and 48 h in a dose- and time-dependent manner.


All combinations displayed synergistic effects against MDA-MB-231 cells at 48 h, particularly with combination 1 (bromelain 2 µM + cisplatin 1.5 µM).

Interestingly, combination 1 also was found to induce breast cancer cells death with a significant decrease in the levels of several apoptotic proteins but an increase of levels of the pro-apoptotic proteins compared with bromelain.

Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.



Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Bromelain-Functionalized Multiple-Wall Lipid-Core Nanocapsules: Formulation, Chemical Structure and Antiproliferative Effect Against Human Breast CancerCells (MCF-7) by Oliveira CP1,2, Prado WA3, Lavayen V3, Büttenbender SL3, Beckenkamp A4, Martins BS3, Lüdtke DS3, Campo LF3, Rodembusch FS3, Buffon A4, Pessoa A Jr5, Guterres SS4, Pohlmann AR. (PubMed)
(2) Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro by Pauzi AZ1, Yeap SK2, Abu N1, Lim KL3, Omar AR2, Aziz SA4, Chow AL1, Subramani T1, Tan SG1, Alitheen NB. (PubMed)
(3) Dietary fat and risk of breast cancer by Bhaskarapillai Binukumar1 and Aleyamma Mathew. (PMC)

Herbal Turmeric, the Potential and Natural Neuroprotective Remedy

Scientists may have found a herbal spice which processed bioactive ingredients for the treatment of neuro-disorder with no side effects, according to studies.

Neuroprotection an action involved the use of a natural substance to protect the integrity and viability of neurons against damage or death.

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neuron in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Most common disease associated with neuro-degenerative diseases is dementia, a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease.



The disease has been found to negatively influence the body's functioning, including balance, movement, talking, breathing, and heart function.

There are many risk factors that cause the onset of the progressive death of brain neurons. Genetic preposition, medical condition, such as alcoholism, brain cancer, or a stroke in the brain.

A prolonged period of toxins, toxic chemicals accumulated that affects the brain function also have a strong impact to induce the onset of the disease.

Out of many factors, some researchers suggested that the prevalence of obesity may process some negative implications in stimulating the rise of neurodegenerative disease in older adults in the Western world.

Dr. Daniel Shalev, the lead scientist wrote, "So how does obesity or diabetes contribute to a 50% increase in the risk of dementia?".


And, "Many of the same processes that affect coronary arteries and visceral organs also impact the brain. Inflammation leads to the activation of microglia and astrocytes. This causes the release of cytokines and reactive oxidants, ultimately leading to neuronal dysfunction or death. Critically, this process can unleash a vicious cycle: dying neurons can cause more inflammation, thereby creating a cascade of neurodegeneration".


The findings strongly suggested if you are obese, your risk of dementia is substantially higher compared to non-obese individuals.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound which processes neuroprotective activity, researchers evaluated the neuroprotective effects of extracts from the radix of C. aromatica (ECAs, Turmeric) on free radical damage cells.

The study included the model of oxidative stress damage (H2O2-damaged PC12 cells) induced by injection of 400 µM H2O2.

Compared to ECAs as the same doses, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric showed markedly the increase of the rate of neuron survival and enhancement of the antioxidant enzyme activities via the inhibition of the level of ROS.

In other words, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric exerted a better neuron-protective and antioxidant activity than of ECAs.

Furthermore, the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) also attenuated the intracellular Ca2+ overloading in the induction of psychiatric overtones, such as depression, anxiety, cognitive dysfunction and decreased the activation of proteins and matrixes involved cell apoptosis, similar to those of ECAs.

The efficacy of the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) against the degeneration of neurons was attributed to the presence of the active compound diarylheptanoids.

Based on the finding, researchers wrote, "These findings indicated that the effects of HCECA and MCECA on inhibiting the cells damage induced by H2O2 in PC12 are better than other extracts from the radix of C. aromatica".


In order to reveal more information about turmeric neuroprotective effects, researchers evaluated the effects of curcumin against nicotine-induced apoptosis, oxidative stress, and inflammation in an animal model.

This study included 60 adult male rats divided randomly into six groups. Group 1 received 0.7 ml/rat normal saline, group 2 received 6 mg/kg nicotine. Groups 3, 4, 5 and 6 were treated concurrently with nicotine (6 mg/kg) and curcumin (10, 20, 40 and 60 mg/kg i.p. respectively) for 21 days.

According to the Open Field Test (OFT), curcumin-treated groups (40 and 60 mg/kg) reduced the nicotine-induced motor activity disturbances.

Before injection of curcumin nicotine treatment showed the increase of lipid peroxidation observed by the overexpression of ROS, proinflammatory cytokines, and protein associated with neuron-apoptosis in the hippocampus.

Furthermore, nicotine also reduced the activity of antioxidant enzymes in the tested rats in the hippocampus.


Injection of curcumin reversed all alternation by attenuating nicotine-induced apoptosis, oxidative stress and inflammation; and elevating the levels P-CREB and BDNF associated with the improvement of cognitive function,

Taken altogether, turmeric and its bioactive compounds, particularly curcumin may be considered a supplement for the protection of neurons' integrity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective Effects of Extracts from the Radix Curcuma aromatica on H2O2-induced Damage in PC12 Cells by Liu J1, Zhang L1, Liu D1, Li B1, Zhang M. (PubMed)
(2) The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway by Motaghinejad M1, Motevalian M2, Fatima S2, Faraji F2, Mozaffari S. (PubMed)
(3) Metabolism and Memory: Obesity, Diabetes, and Dementia by Daniel Shalev and Melissa R. Arbuckle. (PMC)

Herbal Arctostaphylos uva-ursi and antiinflammatory activities

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe. The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stones, pelvic pain, etc.
Inflammation is a condition of Immune system self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.

The Ingredients It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.

The benefits
Water extract (UW-ext) collected from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf), is found to exhibit its anti-inflammatory effects in ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema. arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng., when combined with and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis, found to be effective as arbutin may increase the inhibitory action of indomethacin on PC-CD, SRBC-DTH, carrageenin-induced edema, and adjuvant-induced arthritis, but further investigations are required to understand the mechanism involved. Other studies also indicated that 50% methanolic extract (U-ext), containing arbutin, possesses a therapeutic effect against immuno-inflammation induced by picryl chloride (PC-CD) and also increases the inhibitory effect of prednisolone.

The Side effect
1. Overdoses may cause gastrointestinal discomfort, including cause nausea, vomiting, etc. and fever, chills, severe back pain, ringing in the ears, etc.
2. The herb may interact with other medications, including a diuretic
3. Do not use the herb in newborns, children, or if you are pregnant or breastfeeding without approval from the related field specialist.
4. Etc.

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References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)

Turmeric Protects the Stomach Against Gastric Ulcer Developing

Gastric or stomach ulcer is a condition of localized tissue erosion in the lining the stomach.

The most common symptoms of gastric ulcers are abdominal pain, bloating, septic shock, dyspepsia, and blood in the stool due to bleeding, unintended weight loss, and loss of appetite and gastrointestinal discomforts.

Some patients may also experience symptoms of mood disorder, leading to reduced quality of life in many patients.

The imbalance between stomach acid and upper GI tract mucosa are the main cause of the condition onset associated with the use of certain medication, including aspirin, and non-steroidal anti-inflammatory drugs, Helicobacter pylori infection and chronic gastritis.

Epidemiologically, periodontal disease, aging, smoking, long-term use of mechanical ventilation and critical illness are at an increased risk of gastric ulcer.

According to studies gastric ulcer can be preventable, you can protect yourself against the risk gastric ulcer by
1. Adding dietary phytosterols and phospholipids
Experiments using animal peptic ulcer models showed that the lipid fraction in foods from the staple diets of low prevalence areas gave protection against both gastric and duodenal ulceration, including ulceration due to non-steroidal anti-inflammatory drugs (NSAIDs), and also promoted healing of ulceration.

2. Reducing intake of NSAID
NSAID has been proven to cause gastric Ulcer(9), by inhibiting the body’s production of prostaglandins, hormones that protect the stomach lining.

3. Quitting smoking
Cigarette smoking increases xanthine oxidase activity, leukotrienes, and nitric oxide production and also neutrophil infiltration in the gastric mucosa(13).

4. Not missing your dental appointment
The study showed that a significantly higher proportion of subjects with peptic ulcer reported that they lost five or more teeth (35.3 vs. 17.4%, p<0.001) or that they were told they had periodontitis (33.5 vs. 20.7%, p<0.001)(8).

5. Reducing stress
Stress had been found to increase the onset of gastric ulcer in people who suffered from the Great East Japan earthquake and tsunami. The incidence of all types of peptic ulcers was 1.5-fold increased after the earthquake.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the treatment of gastric ulcer, researchers examined the intact (TrPP) and modified, and the low-molecular-weight (MTrPP) forms of pectic polysaccharides isolated from turmeric against a gastric ulcer in vitro and in vivo models.

Compared to TrPP, MTrPP possessed a significantly better ulcer-preventive property by inhibiting ulcer scores up to 85%.

More precisely, MTrPP exerted an effective muco-protection, inhibited the expression of H(+), K(+)-ATPase in the ulcer forming and of H. pylori growth/adherence, higher antioxidant/cytoprotective mechanisms associated to the gastric lesion.

By comparing the chemical contents in TrPP, and MTrPP, researchers suggested that the efficacy of MTrPP in the protection against the formation of the gastric ulcer may be attributed to the levels of galacturonic acid (687mg/g; TrPP-544mg/g) and galactose (52.9%; TrPP-21.7%) in the inhibition of inflammation.

In other words, the low molecular weight of MTrPP (155kDa; TrPP-13kDa) possesses higher antiulcer potential compared to that of TrPP.


In order to reveal more information about turmeric anti-gastric ulcer activity, researchers evaluated the effect of C. Angustifolia and M. arundinacea on forced swimming-induced hypothermia and gastric ulceration in rats.

According to the observation of 72 hours periodically and mortality recorded up to seven days, the application of both drugs did not produce any toxic symptoms or mortality even up to the maximum dose level of 4400 mg/kg.

Both the test drugs showed a significantly reversed the stress-induced gastric ulceration compared to stress-control rats.

Taken altogether, curcumin used in the intact (TrPP) and modified, and the low-molecular-weight (MTrPP) forms may be considered a remedy for the prevention and treatment of gastric ulcer, pending to large sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Modified pectic polysaccharide from turmeric (Curcuma longa): A potent dietary component against gastric ulcer by Harsha MR1, Chandra Prakash SV1, Dharmesh SM. (PubMed)
(2) Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of by Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.).
Rajashekhara N1, Ashok BK2, Sharma PP3, Ravishankar B. (PubMed)
(3) Gastric Ulcers: Preventions – The do and do not’s list by Kyle J. Norton

Herbal Turmeric, Promotes the Reproductive System Functioning in Vitro and Vivo

The reproductive system is a system of sex organs with a function to produce offspring.

In males, the reproductive system consists of the testes, where sperm is produced, and the penis.

In females, the structures of the reproductive system include the clitoris, labia minora, labia majora, and Bartholin's glands and internal structures include the vagina, uterus, and the ovaries.

The most common cause of reproductive organ disease is an infection. In females, reproductive tract infections can affect the upper reproductive tract (fallopian tubes, ovaries, and uterus) and the lower reproductive tract (vagina, cervix, and vulva).

In males, most cases of infection are found on the penis, testicles, urethra, or the vas deferens.


Some cases of reproductive diseases such as cancer have been found to affect reproductive functioning, leading to infertility.

Fertility is a natural capability to produce offspring. Infertility is a condition in which the couple fails to conceive after 12 months of unprotected sexual intercourse or the female cannot carry the pregnancy to full term.

According to the statistics, over 5 millions couple alone in the U. S. and many times more in the world, because of unawareness of treatments, only 10% seeks help from a professional specialist.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural compound for the improvement of reproductive functioning, researchers
examined the effects of Curcuma longa and curcumin (CUR) on reproductive systems, by searching the detailed literature survey concentrated on the protective effects of C. longa and curcumin on the activity of the reproductive organs.

According to the results of the searching from PubMed, Web of Science, Google Scholar, Scopus, and Iran- Medex, injection of C. longa and curcumin decreased the risk of cancer and other malignant diseases in the reproductive system by inhibiting the production of the proinflammatory cytokines and promoting the proteins associated with anti-apoptosis in the cells of the reproductive system.

Furthermore, C. longa and curcumin exerted a protective effect on the activity of the reproductive organs through their antioxidant effects in normal cells.

Moreover, C. longa and curcumin also exhibited different reproductive effects depending on the doses and the type of cells.

In order to discover more information about CUR reproductive activity, researchers examined the effect of on testis and testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in rats with establishing chronic variable stress (CVS).


A total of 21 adult male Sprague-Dawley rats included in the study were divided into three groups: 1) control, 2) CVS and 3) CVS+ CUR (100 mg/kg/day dissolved in 0.5 mL of olive oil). All of the animals in control, CVS, and CVS+CUR groups were sacrificed after 15 days.

Injection CUR showed a significant effect in protecting the reproductive functioning by inhibiting the change of normal range testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) serum levels and seminiferous tubule apoptotic cells in the CVS group compared to the control.

Based on the results, Dr. the lead scientist said, "Our findings propose that curcumin might have curative potential on the reproductive system function and its impairment. It's regulated by stress and reproductive-related hormones".

Taken altogether, turmeric and its bioactive compound may be considered remedies for the treatment of reproductive dysfunction, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effects of Curcuma longa and curcumin on reproductive systems by Mohebbati R1, Anaeigoudari A1, Khazdair MR. (PubMed)
(2) Protective effects of curcumin co-treatment in rats with establishing chronic variable stress on testis and reproductive hormones by Mohamadpour M1,2, Noorafshan A1,2, Karbalay-Doust S1,2, Talaei-Khozani T2, Aliabadi E. (PubMed)

Bilberry Protects the Stomach Against Gastric Ulcer, Studies Say

Gastric, stomach ulcer is an oval sore found on the lining of the stomach.

A gastric ulcer is one of the most common types of peptic ulcer disease which affects both the stomach and small intestines.

According to the epidemiological studies, gastric ulcer is caused either by the infection of bacterium Helicobacter pylori (H. pylori) or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin.
The most common symptoms are burning sensation or pain in the stomach. Most patients with gastric ulcers have pain that intensifies on empty stomach, depending on the severity of the condition.


Some patients with gastric ulcers also experience persistent dull pain in the stomach, unintended weight loss, nausea or vomiting, and bloating and acid reflux.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of a gastric ulcer.

Conventionally, most cases of gastric ulcer can be treated successfully depending on the cause, including medicine or surgery if the medicine failed.

Out of many risk factors that cause a gastric ulcer, some researchers suggested there is a correlation between obesity and gastritis as well as gastric ulcers.

Dr. Nadia B. Pietrzykowska said, "Excess body weight has been linked to various abdominal ailments. These may include abdominal pain, bloating, vomiting, heartburn, diarrhea or constipation".

And, "Scientific studies are also increasingly reporting a correlation between obesity and gastritis as well as gastric ulcers. A recent, large study that specifically focused on analyzing gastric and duodenal ulcers confirmed that excess weight predisposed individuals to gastric ulcers when compared to their normal-weight counterparts".


Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.


In the testing of the effect of Vaccinium myrtillus L. anthocyanoside (VMA) used as a folk medicine to treat diseases related to gastric ulcers in northern Europe, researchers investigated the protective effects of VMA on gastric mucosal damage in a murine gastric ulcer model.

During the experiment, oral administration of VMA (10, 30 and 100 mg/kg) significantly protected gastric mucosa against HCl/ethanol-induced gastric ulcers.

VMA protected the stomach by inhibiting lipid peroxide levels in a concentration-dependent manner and exhibiting the high scavenging activity against the superoxide anion radical (·O(2) (-) ) and the hydroxyl radical (·OH).
The antioxidant activity in VMA was found to be attributed to the presence of anthocyanidins and delphinidin.

Based on the findings, Dr. Ogawa K, the lead scientist said, "These findings indicate that the protective effects of VMA on HCl/ethanol-induced gastric mucosal injury may be partially due to the antiperoxidative effects of anthocyanidins".

In order to provide more information about VMA gastric protective effects, researchers examined the antiulcer effects of 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-1-benzopyrylium chloride (IdB 1027,
an anthocyanidin from Vaccinium myrtillus) in various experimental models.


Orally, IdB 1027 inhibited all parameters associated with the onset of gastric ulcerations including anti-inflammatory drugs, ethanol, reserpine, histamine and duodenal ulceration induced by mercaptamine.

Furthermore, IdB 1027 also protected the stomach against chronic gastric ulcers induced by acetic acid.

Moreover, IdB 1027 in rat model did not affect gastric secretion in pylorus-ligated rats and increased gastric mucus in normal animals both in the absence and in the presence of indomethacin treatment.

In other words, IdB 1027 possessed a promising antiulcer activity, probably by potentiating the defensive barriers of the gastrointestinal mucosa.

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of gastric ulcer, pending to the validation of larger sample size and multicenter human study.




Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice by Ogawa K1, Oyagi A, Tanaka J, Kobayashi S, Hara H. (PubMed)
(2) Antiulcer activity of an anthocyanidin from Vaccinium myrtillus by Magistretti MJ1, Conti M, Cristoni A. (PubMed)
(3) Obesity and Gastric Ulcers by Dr. Nadia B. Pietrzykowska. (OMC community)

Bromelain, the Natural Prevention and Treatment of Inflammatory Bowel Disease (IBD)

Inflammatory bowel disease (IBD) is a digestive condition characterized by an inflammation of the large intestine. The disease affects over 1.6 million Americans today.

Most common types of IBD are
*Crohn’s disease (CD) is an inflammation of any part of the digestive tract. Most cases of CD affect the tail end of the small intestine.

* Ulcerative colitis is an inflammation of the large intestine.

The exact causes of inflammatory bowel disease are unknown. However, some researchers do know that
* The disease may be caused by the weakened immune system that fails to kill off the invasion of infectious micro-organisms in the acute phase of digestive infection caused by tissue injury and damage.

* IBD may be a result of the immune dysfunction mistakenly attacking the digestive tract, a case of autoimmune disease.

* Imbalance of ratio of good and bad bacteria in the colon, caused by long-term intake of certain medicines.

* IBD is also associated with age, family history, ethnicity, parasite, and smoking.

* Genetic mutation of NOD2, ATG16L1and IL23R involved in innate immunity, in the autophagy, and in the inflammatory response may also elevate the risk of IBD.

Believe it or not, if you are living in the Western world, you are also at a higher risk of the disease. For example, people who live in Western countries such as the United States and Europe have a higher IBD risk than those in other parts of the world.

Some researchers suggested an individual diet pattern may influence the risk of IBD.

Dr. Donjete Statovci, the lead scientists wrote, "Westernized diet, defined as high dietary intake of saturated fats and sucrose and low intake of fiber, represent a growing health risk contributing to the increased occurrence of metabolic diseases, e.g., diabetes and obesity in countries adopting a westernized lifestyle. Inflammatory bowel diseases (IBD) and asthma are chronic mucosal inflammatory conditions of unknown etiology with increasing prevalence worldwide".


And, "Recent reports indicate that the gut microbiota and modifications thereof, due to the consumption of a diet high in saturated fats and low in fibers, can trigger factors regulating the development and/or progression of both conditions".

In other words, by pursuing a healthy diet with a higher in fruits and vegetables and reducing intake of red meat, saturate and trans fat and processed foods, IBD is preventable.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In an aim to find the potential compound for the treatment of inflammatory bowel disease, researchers examined the efficacy of bromelain in colitis in an animal study.

According to the tested assays, daily treatment with oral bromelain at the age for 5 weeks showed a significant effect on decreasing the incidence and severity of spontaneous colitis in C57BL/6 IL-10-/- mice.

Furthermore, bromelain also significantly decreased the severity of colonic inflammation by inhibiting the production of the pro-inflammatory cytokine in mice colitis induced by piroxicam exposure.

Moreover, bromelain anti-inflammatory effects were associated with the exertion of proteolytical activity.

In wild-type mice treated orally with up to 1000 mg bromelain/kg/day for 18 weeks, researchers do not observe ant adverse effects such as dermatitis, hair loss, and weight loss due to mucositis.


Based on the findings, researchers wrote, " the results justify additional studies of this complementary biologically based approach to the treatment of IBD".

Also in the animal model, short-term oral treatment with bromelain was found to decrease the severity of colonic inflammation in C57BL/6 Il10(-/-) mice with chronic colitis.

Mice treated with fresh pineapple juice at a level equivalent to 14 mg bromelain purified from the stem decreased histologic colon inflammation scores and a lower incidence of inflammation-associated colonic neoplasia (35% versus 66%; P < 0.02), with fewer neoplastic lesions/colon.

According to the flow cytometric analysis, murine splenocytes exposed to fresh pineapple juice in vitro effect leukocyte trafficking and activation in facilitating the production of pro-inflammatory cytokines associated with immune response.


Dr. Hale LP, the lead scientist after taking into account co and confounders wrote, " long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".

Taken altogether, bromelain may be considered a remedy for the prevention and treatment of inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.


Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease by Hale LP1, Greer PK, Trinh CT, Gottfried MR. (PubMed)
(2) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)
(3) The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces by Donjete Statovci,1 Mònica Aguilera,1 John MacSharry,1,2 and Silvia Melgar. (PMC)