Memory impairment is a condition associated with a slow decline in memory, thinking and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.
Memory loss can be temporarily forgotten, such as forgetting to pay a monthly bill and permanent such as no longer know your name. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.
Some memory changes can be resolved on their own or cured by medical treatment. Others due to the loss of neuron and quantity capacity cannot be revered such as dementia.
According to statistics, dementia affects 47.5 million people worldwide. Every year over 7.7 million new cases are diagnosed. The disease is a leading cause of dependency and mental impairment among the elderly population.
The aim of the treatment of irreversible memory impairment is to improve the quality of life by delaying the progression of underlying diseases such as AD and PD.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a potential compound for the treatment of memory deficits, with no side effects compared to those of conventional medicine, researchers examined the effects of anthocyanin pigments, a group of flavonoids, and a widespread class of phenolic compounds found abundantly in bilberry.
The study included the examination of elevated plus-maze and radial maze tasks cognitive performance fed approximately 3.2 mg kg(-1)day (oral) the anthocyanins. The lyophilized berries were administered for 30 days before the first training.
According to the step-down inhibitory avoidance, open field analysis, lyophilized berries significantly enhanced short-term memory, but not long-term memory and induced an increase in the number of crossings in the first exposure to the open field.
Interestingly, prolonged treatment with lyophilized berries did not have any significant effects in the elevated plus-maze task but improved working memory in the radial maze, with significant differences observed during sessions 1-2 and 4, but did not alter reference memory in this task.
Researchers after taking into account co and confounders wrote in the final report, "These results suggest that lyophilized berries may be beneficial in the prevention of memory deficits, one of the symptoms related to AD, and corroborate previous findings showing that flavonoids present effects in several learning paradigms".
In other words, the efficacy of bilberry protects the memory function against the onset of deficits was attributed to the bioactive compound anthocyanin.
Taken altogether, bilberry processed abundantly bioactive compound Anthocyanoside may be considered a functioning remedy for the prevention and treatment symptom of memory deficits in patients with AD, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats by Ramirez MR1, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT. (PubMed)
Sunday, June 28, 2020
Saturday, June 27, 2020
Bromelain Protects the Joints Against Osteoarthritis
Osteoarthritis (OA), a form of arthritis, is a chronic condition found mostly in elderly caused by of wear and tear on a joint.
The University of Porto Medical School in the definition of OA advised that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip, and hand joints(3).
The condition affects over 25 million people in the United States.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. The pain usually gets worse in a change of weather, at night, and in the advanced diseases, the pain can occur even at rest.
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function and quality of life through pharmacological, nonpharmacological, and surgical treatments.
Most common causes of OA are
* Process of wear and repair
Osteoarthritis (OA), is a widespread degenerative disease of skeletal joints often associated with senescence invertebrates. arising from long term wear and tear, heavy long-term use or specific injuries. The improper repair process of injuring joints can also result in symptoms of osteoarthritis (OA) in old age, according to TCM.
* Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA), such as vitamin D. On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to early onset of osteoarthritis (OA).
* Cartilage
Cartilage is a flexible connective tissue cushioned the ends of bones in the joints that allow the joints to move smoothly. Rough or wears down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone.
The above causes of Osteoarthritis (OA) may also be the result of injury, overuse, and Rheumatoid Arthritis,
In other words, lifelong protection of cartilage and joint damage and injury has an inverse association with the risk of OA.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural resource for the treatment of osteoarthritis, researchers compared the effect of a combination of bromelain, trypsin, and rutin (ERC) to diclofenac.
The study included103 patients with osteoarthritis of the knee randomly received either the combination of bromelain, trypsin, and rutin or diclofenac including 52 patients treated with ERC and 51 patients treated with the diclofenac.
According to the tested assay,
* The mean value of the Lequesne's Algofunctional Index (LFI) decreased from 13.0 to 9.4 in the ERC group and from 12.5 to 9.4 in the diclofenac group.
* Non-inferiority of ERC was demonstrated by both primary criteria, LFI (MW = 0.5305; CI-LB = 0.4171) and complaint index (MW = 0.5434; CI-LB = 0.4296).
Where LFI is a measurement of the severity of osteoarthritis.
* ERC also showed the superior improvement of secondary efficacy criteria, compared to diclofenac
* The global judgment of efficacy by physician resulted in at least good ratings for 51.4% of the ERC patients, and for 37.2% of the diclofenac patients.
Furthermore, the majority of patients rate the tolerability in both drug groups as very good or good.
Based on the finding, researchers wrote, " ERC can be considered as an effective and safe alternative to NSAIDs such as diclofenac in the treatment of painful episodes of OA of the knee".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton
The University of Porto Medical School in the definition of OA advised that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip, and hand joints(3).
The condition affects over 25 million people in the United States.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. The pain usually gets worse in a change of weather, at night, and in the advanced diseases, the pain can occur even at rest.
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function and quality of life through pharmacological, nonpharmacological, and surgical treatments.
Most common causes of OA are
* Process of wear and repair
Osteoarthritis (OA), is a widespread degenerative disease of skeletal joints often associated with senescence invertebrates. arising from long term wear and tear, heavy long-term use or specific injuries. The improper repair process of injuring joints can also result in symptoms of osteoarthritis (OA) in old age, according to TCM.
* Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA), such as vitamin D. On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to early onset of osteoarthritis (OA).
* Cartilage
Cartilage is a flexible connective tissue cushioned the ends of bones in the joints that allow the joints to move smoothly. Rough or wears down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone.
The above causes of Osteoarthritis (OA) may also be the result of injury, overuse, and Rheumatoid Arthritis,
In other words, lifelong protection of cartilage and joint damage and injury has an inverse association with the risk of OA.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural resource for the treatment of osteoarthritis, researchers compared the effect of a combination of bromelain, trypsin, and rutin (ERC) to diclofenac.
The study included103 patients with osteoarthritis of the knee randomly received either the combination of bromelain, trypsin, and rutin or diclofenac including 52 patients treated with ERC and 51 patients treated with the diclofenac.
According to the tested assay,
* The mean value of the Lequesne's Algofunctional Index (LFI) decreased from 13.0 to 9.4 in the ERC group and from 12.5 to 9.4 in the diclofenac group.
* Non-inferiority of ERC was demonstrated by both primary criteria, LFI (MW = 0.5305; CI-LB = 0.4171) and complaint index (MW = 0.5434; CI-LB = 0.4296).
Where LFI is a measurement of the severity of osteoarthritis.
* ERC also showed the superior improvement of secondary efficacy criteria, compared to diclofenac
* The global judgment of efficacy by physician resulted in at least good ratings for 51.4% of the ERC patients, and for 37.2% of the diclofenac patients.
Furthermore, the majority of patients rate the tolerability in both drug groups as very good or good.
Based on the finding, researchers wrote, " ERC can be considered as an effective and safe alternative to NSAIDs such as diclofenac in the treatment of painful episodes of OA of the knee".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) Most Common Disease of elder: The Clinical Trials and Studies of musculoskeletal disorders(MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton
Friday, June 26, 2020
Herbal Bilberry, the Atheroprotective Functional Food
Atherosclerosis is a condition associated with the accumulated plaque on the arterial wall. Over time the condition can cause stiffening and hardening of the arterial, leading to cardiovascular disease.
Atheroprotection is an action that reduces the plaque build up on the arterial wall. In other words, anything, including the use of substances such as herbal remedy that prevents the blockage or narrowing of the arteries is considered to precess atheroprotective effects.
Although plaque is formed by substances found in the bloodstream, most cases of atherosclerosis are also associated with the amount of cholesterol which normally returned to the liver in healthy individuals remaining in the blood due to low levels of good cholesterol (HDL) or overexpression of bad cholesterol (LDL).
In other words, an unhealthy ratio of low and high-density lipoprotein is also one of the major risk factors of atherosclerosis. the healthy ratio of blood cholesterol is any number that is less than 4 (LDL)/ 1 )HDL)
Dr. Ilaria Zanotti, the lead scientist in the investigation of atheroprotective effects of (poly) phenols wrote, "epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis".
And, "... recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation".
The results strongly suggested a healthy diet including nuts, coffee, cocoa, grapes, and berries may have a profound effect on the prevention of atherosclerosis.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a potent ingredient that processes atheroprotective effects, researchers assessed the results of the intake of bilberry foods associated with a reduced risk of cardiovascular diseases from the previous study.
2 bilberry extracts included one rich in anthocyanins extracted from untreated bilberries (BE) and a second one extracted from yeast-fermented bilberries (FBE).
On atherosclerosis induced apolipoprotein E-deficient mice (apo E(-/-)) received for 16 weeks a diet supplemented with 0.02% of either BE or FBE.
According to the measurement of atherosclerotic plaque area, administration of both supplementations bilberry extracts led to significant inhibition of plaque development, without affecting on oxidative stress parameters or lipid profiles.
The results surprisingly suggested bilberry supplement inhibited the atherosclerotic development through other mechanisms unrelated to inflammation and lipoproteins.
Compared to BE, FBE showed better protection against plaque accumulation on the arterial walls.
The finding firmly showed that the fermentation must have generated new bioactive compounds that are found in the BE extracts.
In other words, other compounds found in bilberry fermentation are more effective in attenuating the progression of atherosclerotic lesions.
Taken altogether, bilberry, particularly bilberry fermentation processed abundantly bioactive compounds anthocyanins may be considered function remedies for the prevention and treatment of atherosclerosis, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Atheroprotective effects of bilberry extracts in apo E-deficient mice by Mauray A1, Milenkovic D, Besson C, Caccia N, Morand C, Michel F, Mazur A, Scalbert A, Felgines C. (PubMed)
(2) Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism by Ilaria Zanotti, Margherita Dall'Asta, Pedro Mena and Laura Mele ( Research Gate)
Atheroprotection is an action that reduces the plaque build up on the arterial wall. In other words, anything, including the use of substances such as herbal remedy that prevents the blockage or narrowing of the arteries is considered to precess atheroprotective effects.
Although plaque is formed by substances found in the bloodstream, most cases of atherosclerosis are also associated with the amount of cholesterol which normally returned to the liver in healthy individuals remaining in the blood due to low levels of good cholesterol (HDL) or overexpression of bad cholesterol (LDL).
In other words, an unhealthy ratio of low and high-density lipoprotein is also one of the major risk factors of atherosclerosis. the healthy ratio of blood cholesterol is any number that is less than 4 (LDL)/ 1 )HDL)
Dr. Ilaria Zanotti, the lead scientist in the investigation of atheroprotective effects of (poly) phenols wrote, "epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis".
And, "... recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation".
The results strongly suggested a healthy diet including nuts, coffee, cocoa, grapes, and berries may have a profound effect on the prevention of atherosclerosis.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
With an aim to find a potent ingredient that processes atheroprotective effects, researchers assessed the results of the intake of bilberry foods associated with a reduced risk of cardiovascular diseases from the previous study.
2 bilberry extracts included one rich in anthocyanins extracted from untreated bilberries (BE) and a second one extracted from yeast-fermented bilberries (FBE).
On atherosclerosis induced apolipoprotein E-deficient mice (apo E(-/-)) received for 16 weeks a diet supplemented with 0.02% of either BE or FBE.
According to the measurement of atherosclerotic plaque area, administration of both supplementations bilberry extracts led to significant inhibition of plaque development, without affecting on oxidative stress parameters or lipid profiles.
The results surprisingly suggested bilberry supplement inhibited the atherosclerotic development through other mechanisms unrelated to inflammation and lipoproteins.
Compared to BE, FBE showed better protection against plaque accumulation on the arterial walls.
The finding firmly showed that the fermentation must have generated new bioactive compounds that are found in the BE extracts.
In other words, other compounds found in bilberry fermentation are more effective in attenuating the progression of atherosclerotic lesions.
Taken altogether, bilberry, particularly bilberry fermentation processed abundantly bioactive compounds anthocyanins may be considered function remedies for the prevention and treatment of atherosclerosis, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Atheroprotective effects of bilberry extracts in apo E-deficient mice by Mauray A1, Milenkovic D, Besson C, Caccia N, Morand C, Michel F, Mazur A, Scalbert A, Felgines C. (PubMed)
(2) Atheroprotective effects of (poly) phenols: A focus on cell cholesterol metabolism by Ilaria Zanotti, Margherita Dall'Asta, Pedro Mena and Laura Mele ( Research Gate)
Thursday, June 25, 2020
Bromelain Modulated the Immune System Against the Development of Diseases
The immune system is a network of cells, tissues, and organs that provide the body's defense against infectious organisms and pathogens.
The immune system can be classified into innate immunity and adaptive immunity
* Innate immunity comprised the cells and mechanisms is the process of the immune response against infection in a non-specific manner.
* Adaptive immunity or acquired immunity is the process to destroy pathogens or prevent their growth by a composed of highly specialized, systemic cells that have been causing a threat to the body in the past.
Diseases associated with the immune system can also be classified into underactive immunity and overactive immunity
* Underactive immunity also known as weakened immune function is a condition found mostly in people with chronic illness, the elderly, and children with immature immunity.
People with a weakened immune system are prone to infectious diseases.
* Overactive immunity associated with autoimmune diseases, including celiac disease, diabetes mellitus type 1, Graves'disease, inflammatory bowel disease, caused by allergens induced the immune system mistakenly attacking the body tissues.
In an inflammatory perspective, the chronic inflammatory diseases are also caused by the immune system failure in destroying all foreign invaders in the acute infection in a set period of time, leading to immune adaptation with the long-term production of pro-inflammatory cytokines.
Diseases associated with chronic inflammation include type II diabetes, cardiovascular disease.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the modulation of the immune system, researchers examined the effects on inflammation-related cytokines of two doses of bromelain in a single dose placebo-controlled 3 × crossovers randomized clinical trial.
Injection of bromelain demonstrated significant immune-modulatory effects on Th1 cell mediator interferon-gamma in response to antigenic stimulation, Th2-type cytokine IL-5 in the regulation of humoral immune responses to extracellular parasites and bacterial infection as well as the immunosuppressive cytokine interleukin (IL)-10.
In other words, bromelain has a general effect on the antigen-specific (T cell) compartment of the human immune system in the modulation of cellular responses of lymphocyte.
In order to obtain more information of bromelain immunomodulatory effects, researchers investigated the influence of bromelain and trypsin on the cytokine production and proliferation of peripheral blood mononuclear cells (PBMC) from patients with a classical cellular mediated autoimmune disorder, namely, encephalomyelitis disseminate (ED) as well as from healthy controls.
The experiment carried out with PBMC from patients with ED (n=12) and healthy controls (n=12) cultured for seven days at 37 degrees C under three different conditions: without antigen, with bromelain and with trypsin (final concentrations 10-1000 microg/ml).
Compared to trypsin, PBMC from patients with ED and healthy controls showed a significantly increased proliferative response to bromelain (ED: 14053+/- 7585 CPM with bromelain vs. spontaneous proliferation of 430+/- 255 CPM; healthy controls.
Furthermore, bromelain modulated the immune expression by activating macrophages/monocytes and type 1 cells associated with the adaptive immunity process independently from the underlying disease.
Taken altogether, bromelain may be considered a remedy for the modulation of immune function, pending to the confirmation of large sample size and multicenter study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain by Müller S1, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. (PubMed)
(2) In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans by Barth H1, Guseo A, Klein R. (PubMed)
The immune system can be classified into innate immunity and adaptive immunity
* Innate immunity comprised the cells and mechanisms is the process of the immune response against infection in a non-specific manner.
* Adaptive immunity or acquired immunity is the process to destroy pathogens or prevent their growth by a composed of highly specialized, systemic cells that have been causing a threat to the body in the past.
Diseases associated with the immune system can also be classified into underactive immunity and overactive immunity
* Underactive immunity also known as weakened immune function is a condition found mostly in people with chronic illness, the elderly, and children with immature immunity.
People with a weakened immune system are prone to infectious diseases.
* Overactive immunity associated with autoimmune diseases, including celiac disease, diabetes mellitus type 1, Graves'disease, inflammatory bowel disease, caused by allergens induced the immune system mistakenly attacking the body tissues.
In an inflammatory perspective, the chronic inflammatory diseases are also caused by the immune system failure in destroying all foreign invaders in the acute infection in a set period of time, leading to immune adaptation with the long-term production of pro-inflammatory cytokines.
Diseases associated with chronic inflammation include type II diabetes, cardiovascular disease.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the modulation of the immune system, researchers examined the effects on inflammation-related cytokines of two doses of bromelain in a single dose placebo-controlled 3 × crossovers randomized clinical trial.
Injection of bromelain demonstrated significant immune-modulatory effects on Th1 cell mediator interferon-gamma in response to antigenic stimulation, Th2-type cytokine IL-5 in the regulation of humoral immune responses to extracellular parasites and bacterial infection as well as the immunosuppressive cytokine interleukin (IL)-10.
In other words, bromelain has a general effect on the antigen-specific (T cell) compartment of the human immune system in the modulation of cellular responses of lymphocyte.
In order to obtain more information of bromelain immunomodulatory effects, researchers investigated the influence of bromelain and trypsin on the cytokine production and proliferation of peripheral blood mononuclear cells (PBMC) from patients with a classical cellular mediated autoimmune disorder, namely, encephalomyelitis disseminate (ED) as well as from healthy controls.
The experiment carried out with PBMC from patients with ED (n=12) and healthy controls (n=12) cultured for seven days at 37 degrees C under three different conditions: without antigen, with bromelain and with trypsin (final concentrations 10-1000 microg/ml).
Compared to trypsin, PBMC from patients with ED and healthy controls showed a significantly increased proliferative response to bromelain (ED: 14053+/- 7585 CPM with bromelain vs. spontaneous proliferation of 430+/- 255 CPM; healthy controls.
Furthermore, bromelain modulated the immune expression by activating macrophages/monocytes and type 1 cells associated with the adaptive immunity process independently from the underlying disease.
Taken altogether, bromelain may be considered a remedy for the modulation of immune function, pending to the confirmation of large sample size and multicenter study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration - new evidence on the antiinflammatory mode of action of bromelain by Müller S1, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. (PubMed)
(2) In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans by Barth H1, Guseo A, Klein R. (PubMed)
Wednesday, June 24, 2020
Herbal Ashwagandha Improves Cardiorespiratory Endurance in Healthy Athletic Adults
The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.
Cardiorespiratory endurance is a measurement of how well your heart, lungs, and muscles work over an extended period of time of physical activity.
Participating in a program of regular aerobic exercise has been found to improve cardiorespiratory endurance in athletes.
In other words, healthy individuals with optimal cardiorespiratory endurance have been found to benefits from reducing the risk of heart disease, lung cancer, type 2 diabetes, stroke, and other diseases.
Furthermore, cardiorespiratory fitness also improves the lung and heart condition and increases feelings of wellbeing.
An article posted in the Medical News Today regarded to the health benefits of cardiorespiratory fitness wrote, "Scientific research also suggests some other potential health benefits from having an improved cardiorespiratory endurance" and "For example:
A 2017 study suggests that people with higher cardiorespiratory endurance are less likely to develop high blood pressure than those with a lower cardiorespiratory endurance.
In a 2015 study, researchers found a positive correlation between cardiorespiratory endurance levels and multitask performance among adults aged between 59 and 80 years.
Improving cardiorespiratory endurance may decrease the risk of coronary heart disease and all-cause mortality, according to a 2015 study".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a natural ingredient for the improvement of health-fitness, researchers examined the clinical efficacy of herbal Ashwagandha on cardiovascular endurance and physical performance.
According to the results from a prospective, double-blind, randomized, and placebo-controlled study included 50 healthy male/female athletic adults,
* Participant reived KSM-66 Ashwagandha showed a greater increase from baseline in the mean peak physical exertion (VO2 max compared to placebo (n = 25) at 8 weeks (4.91 and 1.42, respectively) and at 12 weeks.
* Furthermore, at week 12, the Ashwagandha group showed an improvement of the quality of life (QOL) scores for all subdomains significantly, compared to placebo (P < 0.05).
In other words, Ashwagandha root extract enhances the cardiorespiratory endurance and improves QOL in healthy athletic adults.
Taken altogether, Ashwagandha may be considered supplements for the promotion of cardiovascular endurance and physical performance in healthy exercisers, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults by Bakhtiar Choudhary, A. Shetty,1 and Deepak G.
Langade. (PMC)
(2) What to know about cardiorespiratory endurance by Gerhard Whitworth, R.N. on June 17, 2019 — Written by Jamie Eske. (Medical News Today)
Cardiorespiratory endurance is a measurement of how well your heart, lungs, and muscles work over an extended period of time of physical activity.
Participating in a program of regular aerobic exercise has been found to improve cardiorespiratory endurance in athletes.
In other words, healthy individuals with optimal cardiorespiratory endurance have been found to benefits from reducing the risk of heart disease, lung cancer, type 2 diabetes, stroke, and other diseases.
Furthermore, cardiorespiratory fitness also improves the lung and heart condition and increases feelings of wellbeing.
An article posted in the Medical News Today regarded to the health benefits of cardiorespiratory fitness wrote, "Scientific research also suggests some other potential health benefits from having an improved cardiorespiratory endurance" and "For example:
A 2017 study suggests that people with higher cardiorespiratory endurance are less likely to develop high blood pressure than those with a lower cardiorespiratory endurance.
In a 2015 study, researchers found a positive correlation between cardiorespiratory endurance levels and multitask performance among adults aged between 59 and 80 years.
Improving cardiorespiratory endurance may decrease the risk of coronary heart disease and all-cause mortality, according to a 2015 study".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a natural ingredient for the improvement of health-fitness, researchers examined the clinical efficacy of herbal Ashwagandha on cardiovascular endurance and physical performance.
According to the results from a prospective, double-blind, randomized, and placebo-controlled study included 50 healthy male/female athletic adults,
* Participant reived KSM-66 Ashwagandha showed a greater increase from baseline in the mean peak physical exertion (VO2 max compared to placebo (n = 25) at 8 weeks (4.91 and 1.42, respectively) and at 12 weeks.
* Furthermore, at week 12, the Ashwagandha group showed an improvement of the quality of life (QOL) scores for all subdomains significantly, compared to placebo (P < 0.05).
In other words, Ashwagandha root extract enhances the cardiorespiratory endurance and improves QOL in healthy athletic adults.
Taken altogether, Ashwagandha may be considered supplements for the promotion of cardiovascular endurance and physical performance in healthy exercisers, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults by Bakhtiar Choudhary, A. Shetty,1 and Deepak G.
Langade. (PMC)
(2) What to know about cardiorespiratory endurance by Gerhard Whitworth, R.N. on June 17, 2019 — Written by Jamie Eske. (Medical News Today)
Tuesday, June 23, 2020
Herbal Turmeric Protects Diabetics Against Diabetic Retinopathy
Diabetic retinopathy is one of the diabetes complications caused by long-term uncontrol levels of blood glucose in patients with diabetes, leading to vision loss.
Diabetic macular edema (DME) is swelling in an area of the retinal macula, a consequence of diabetic retinopathy.
The cause of diabetic retinopathy is a result of unmanageable high blood sugar from diabetes associated with damage to the tiny blood vessels in the retina.
Other eye diseases often found in patients with uncontrol blood glucose are
* Cataract, a condition of clouding of the eye’s lens.
Believe or not, patients with diabetes are 2-5 times more likely to develop cataract compared to a healthy individual.
* Glaucoma, a group of diseases that damage the eye’s optic nerve that connects the eye to the brain. Diabetic has nearly doubled the risk of glaucoma, compared to non-diabetics.
At the early stage of hyperglycemia, most patients are asymptomatic. However, at the later stage, the condition affects vision caused bt eh bleeding from abnormal retinal blood vessels.
Conventionally, diabetic retinopathy diagnosed and treated early were found to reduce diabetic retinopathy risk by 95%. However, late-stage diabetic retinopathy may cause irreversible vision loss.
Please make sure you have eye exams more frequently for preventive measures.
By managing your blood glucose by changing lifestyle with moderate exercise and taking your medication as direct diabetic retinopathy may be preventable.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the prevention of diabetic complications, researchers examined the effect of curcumin, an active ingredient of turmeric on diabetic retinopathy.
In vivo, curcumin inhibited the proliferation of retinal endothelial cells in tested animals.
Curcumolide, a bioactive compound found in turmeric, demonstrates a significant effect in alleviating retinal inflammatory activities both in vitro.
In vivo of STZ-induced diabetic rat model and in TNF-α-stimulated HUVECs, injection of curcumolide exerted anti-inflammatory effects against the inflammatory induction of retinal damage.
Furthermore, curcumolide also alleviated retinal vascular permeability and leukostasis and attenuated the overexpression of proinflammatory cytokines in diabetic retinas.
Based on the findings, researchers wrote in the final report, "These data suggest potential treatment strategies against diabetic retinopathy, particularly in the early stages of the disease".
Taken altogether, turmeric processed a high amount of curcumolide may be considered supplements for the prevention and treatment of diabetic retinopathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diabetic retinopathy: an Indian perspective by Rema M1, Pradeepa R. (PubMed)
(2) Therapeutic potential of curcumin in major retinal pathologies by Peddada KV1, Brown A2, Verma V3, Nebbioso M. (PubMed)
(3) Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-κ B signaling by Cai Y1, Li W1, Tu H1, Chen N1, Zhong Z1, Yan P1, Dong J. (PubMed)
Monday, June 22, 2020
Bromelain Kills Leukemia Cancer Cells
Leukemia is a medical and chronic condition that affects the blood and bone marrow associated with the production of immature white blood cells that can not function properly.
Leukemia can be classified into 2 types
A. Acute leukemia
Acute leukemia is a condition of the rapid increase in the numbers of extreme immature white blood cells which appear in the bloodstream and other parts of the body, including tissue and organs.
* Acute lymphocytic leukemia (ALL) is a type of cancer caused by the abnormal growth of extreme immature lymphocytes by the bone marrow and/or lymphatic system. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia, accounting 80% of all cases.
* Acute myelogenous leukemia (AML) is a cancer of myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal the blood cells.
B. Chronic leukemia
Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells.
* Chronic lymphocytic leukemia (CLL) is a condition caused by slow growth and spreading of a group of abnormal white blood cells called B-cell lymphocytes, which fight against infection in our body by produced antibodies.
* Chronic myelogenous leukemia (CML) is a condition caused by slow growth and spreading of abnormal granulocytes.
The exact causes of leukemia are unidentified. Researchers do not know the exact factors that cause the alternation of cell DNA that promotes the abnormal growth of white blood cells.
However, they do know aging, family factors, male, smoking, long-term exposure to certain chemicals, chemo and radiation therapies, genetic proposition, and certain types of blood disorder are associated with the increased risk of the disease.
Leukemia shared all general symptoms with other types of cancer such as unintended weight loss, loss of appetite, gastrointestinal discomforts, and persistent fatigue accompanied by specific symptoms of bleeding or bruising, recurrent nosebleeds, tiny red spots in your skin, excessive sweating, and hight time bone pain or tenderness.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential compound or whole food for the treatment of leukemia, researchers investigated a panel of cancer cell lines with bromelain in the presence or absence of peroxidase.
Bromelain combined with peroxidase (BM-PR) showed significant inhibition of acute myeloid (K562) cell proliferation and altered the morphological features.
The combination not only exhibited pro-apoptosis against the cancer cell line but also interfered with the cell cycle division through cell cycle arrest.
BM-PR also increased the expression of intracellular ROS level in the induction of cytotoxicity and altered the mitochondrial membrane potential, against the tested cancer cells.
According to the Western blot analysis, BM-PR increased the levels of proteins associated with the activity of proapoptosis and tumor suppression.
Compared to the treatment of bromelain, researchers said, "These results suggest that BM-PR from pineapple induces apoptosis better than the only bromelain in acute myeloid leukemia cells possibly via mitochondria-dependent pathway".
In CD44 cell surface proteins involved in leukocyte binding to endothelium and the metastatic spread of tumor cells, injection of bromelain inhibited the human leukemia Molt 4/8 cells growth by reducing CD44 receptor density.
The most active in reducing CD44 receptor density of bromelain was a half-maximal value of 1.9 mu g/ml and 2.3 mu g/ml.
Based on the findings, bromelain inhibited the progression of leukemia via the reduced CD44 receptor density.
Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of leukemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain with peroxidase from pineapple are more potent to target leukemiagrowth inhibition - A comparison with only bromelain by Debnath R1, Chatterjee N2, Das S3, Mishra S4, Bose D4, Banerjee S4, Das S4, Saha KD5, Ghosh D6, Maiti D. (PubMed)
(2) Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemiaand sk-mel-28 melanoma-cells in-vitro by Harrach T1, Gebauer F, Eckert K, Kunze R, Maurer H. (PubMed)
Leukemia can be classified into 2 types
A. Acute leukemia
Acute leukemia is a condition of the rapid increase in the numbers of extreme immature white blood cells which appear in the bloodstream and other parts of the body, including tissue and organs.
* Acute lymphocytic leukemia (ALL) is a type of cancer caused by the abnormal growth of extreme immature lymphocytes by the bone marrow and/or lymphatic system. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia, accounting 80% of all cases.
* Acute myelogenous leukemia (AML) is a cancer of myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal the blood cells.
B. Chronic leukemia
Chronic leukemia is a condition of the slow but still excessive build-up of relatively mature abnormal white blood cells.
* Chronic lymphocytic leukemia (CLL) is a condition caused by slow growth and spreading of a group of abnormal white blood cells called B-cell lymphocytes, which fight against infection in our body by produced antibodies.
* Chronic myelogenous leukemia (CML) is a condition caused by slow growth and spreading of abnormal granulocytes.
The exact causes of leukemia are unidentified. Researchers do not know the exact factors that cause the alternation of cell DNA that promotes the abnormal growth of white blood cells.
However, they do know aging, family factors, male, smoking, long-term exposure to certain chemicals, chemo and radiation therapies, genetic proposition, and certain types of blood disorder are associated with the increased risk of the disease.
Leukemia shared all general symptoms with other types of cancer such as unintended weight loss, loss of appetite, gastrointestinal discomforts, and persistent fatigue accompanied by specific symptoms of bleeding or bruising, recurrent nosebleeds, tiny red spots in your skin, excessive sweating, and hight time bone pain or tenderness.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to discover a potential compound or whole food for the treatment of leukemia, researchers investigated a panel of cancer cell lines with bromelain in the presence or absence of peroxidase.
Bromelain combined with peroxidase (BM-PR) showed significant inhibition of acute myeloid (K562) cell proliferation and altered the morphological features.
The combination not only exhibited pro-apoptosis against the cancer cell line but also interfered with the cell cycle division through cell cycle arrest.
BM-PR also increased the expression of intracellular ROS level in the induction of cytotoxicity and altered the mitochondrial membrane potential, against the tested cancer cells.
According to the Western blot analysis, BM-PR increased the levels of proteins associated with the activity of proapoptosis and tumor suppression.
Compared to the treatment of bromelain, researchers said, "These results suggest that BM-PR from pineapple induces apoptosis better than the only bromelain in acute myeloid leukemia cells possibly via mitochondria-dependent pathway".
In CD44 cell surface proteins involved in leukocyte binding to endothelium and the metastatic spread of tumor cells, injection of bromelain inhibited the human leukemia Molt 4/8 cells growth by reducing CD44 receptor density.
The most active in reducing CD44 receptor density of bromelain was a half-maximal value of 1.9 mu g/ml and 2.3 mu g/ml.
Based on the findings, bromelain inhibited the progression of leukemia via the reduced CD44 receptor density.
Taken altogether, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of leukemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain with peroxidase from pineapple are more potent to target leukemiagrowth inhibition - A comparison with only bromelain by Debnath R1, Chatterjee N2, Das S3, Mishra S4, Bose D4, Banerjee S4, Das S4, Saha KD5, Ghosh D6, Maiti D. (PubMed)
(2) Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemiaand sk-mel-28 melanoma-cells in-vitro by Harrach T1, Gebauer F, Eckert K, Kunze R, Maurer H. (PubMed)
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