Green tea may have a therapeutic and positive effect in reducing the onset, progression, and treatment of osteoporosis, some scientists suggested.
Osteoporosis is a chronic condition characterized by progression in the reduction of bone mass and deterioration of bone tissue and considered a major health problem in both elderly men and women.
The diseases also affect all bone in the body, including the bones of the spine, hip, and wrist
Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.
Osteoporosis is the common disease among the elderly, probably due to the aging effect that induces nutrition deficiency such as
* Vitamin D insufficiency and reduced calcium absorption,
* Reduced hormone production, the drop of estrogen levels after menopause, can speeds up bone loss.
* Reduced production of bone mass and increased bone reabsorption.
These results suggested that osteoporosis can make the bone more fragile and easier to break. In the elderly, osteoporosis can be dangerous, as fractures can cause prolonged immobility, and required a longer healing process.
Some researchers suggested that fractures in the older population are the most common cause of blood clots or pneumonia, both of which can have fatal consequences.
Long-term use of certain medicines, such as anti-seizure drug Glucocorticoids and medical conditions such as kidney disease, Cushing's syndrome, and an overactive thyroid or parathyroid, can also increase the risk of osteoporosis.
Dr. Stephen P Tuck, the lead author in the study Osteoporosis in men said, "The incidence of osteoporotic fractures in elderly men, just as in aged women, increases exponentially with age; the rise in men, however, is some 5–10 years later than in women. Up to 50% of male osteoporosis have no identifiable etiology; however elderly males have a much higher likelihood of having an identifiable secondary cause than younger men".
Truly, both males and females share the same conditions of the onset of osteoporosis, but the onset of the disease in men is about 10 years later, compared to a woman of the same age.
Interestingly, in the observation of hip fracture in the aging population, Dr. Eric Orwoll, a physician-researcher who studies osteoporosis at Oregon Health and Science University wrote, “A third of all hip fractures occur in men, yet the problem of osteoporosis in men is frequently downplayed or ignored.”
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
In the study to evaluate the effects of ingestion of green tea and green tea bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that the applications exert significant activities in reducing the onset of osteoporosis, through their antioxidants and initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibiting the levels of ROS that facilitate the chain reaction.
Truly, the overexpression of free radicals has been associated with the change in the balance between activities of osteoblasts and osteoclasts, leading to osteoclasts in destroying the calcified tissue and inducing bone remodeling.
These results demonstrated that green tea and its bioactive components exhibit a significant decrease in the risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.
Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that the ingestions display an impressive osteoprotective impact on bone mass and microarchitecture in various bone loss models associated with aging, sex hormone deficiency, and chronic inflammation.
The implication of reduced onset and progression of osteoporosis in the aging population due to sex hormone deficiency may be attributed to green tea and its bioactive compound in increasing the levels of osteocalcin, a bone formation marker, decreasing serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improving the body in the absorption of calcium.
In fact, the serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) are considered effective measurements in the rate of bone turn over in patients with osteoporosis.
Interestingly, application of green tea and its bioactive compound also is found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, through inhibiting the production of C-reactive protein (CRP) in the liver in initiating inflammation and reducing levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.
This differentiation were supported by the study in the evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.
At the end of the experiment, researchers found that rats treated with GTP demonstrate an increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft, and decreased eroded surface in the proximal tibia and endocortical tibial shaft, and increased liver glutathione peroxidase activity.
The findings indicated a strong implication of green tea polyphenols in decreasing cortical and trabecular bone loss and increasing both bone density by stimulating the overexpression of bone formation and reducing bone resorption via antioxidant capacity.
Taken together, green tea and its bioactive polyphenols may be considered functional foods in ameliorating early-onset, progression, and combined with standard medicine for the treatment of osteoporosis.
However, intake of green tea supplements should be taken with extreme care due to recent reports of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS. (PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS. (PubMed)
(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK. (PubMed)
(4) Osteoporosis in the aging male: Treatment option by Stephen P Tuck1 and Harish K Datta. (PubMed)
Monday, July 27, 2020
Saturday, July 25, 2020
Herbal Dandelion(Taraxacum officinale) Inhibits the Diseases Associated with Dengue Virus Serotype 2
Infection is a condition that caused the invasion of stimuli and micro pathogens, including viral infection.
Similar to bacterial infection, both infections shared common characteristics by spreading through coughing and sneezing by and contact with infected people, especially through kissing and sex.
However, unlike bacteria, a virus replicates only inside the living cells of an organism. Viruses can infect all types of life forms, including humans and microorganisms, such as bacteria and archaea.
Anti-viral effects are the process that certain substances are used to cause the destruction of a virus.
In the acute phase of viral infection, depending on the types of viruses, the viruses after entering the body start to attack the specific host cells. The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, will attack the white blood cells of the immune system,
The viral infection has been known to carry over some different stage, after successfully attaching to the host cell, the virus to release its mRNA into the host cell, leading to the recruit of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.
The white blood cells in the systematic immune response in the acute phase of infection stimulate the production of the proinflammatory cytokines to the site of infection with an aim to protect our body by killing off the invaders.
The battle between the immune white blood cell and viral invaders in most cases an in the flavor of the side of the immune system, the invaders are killed and the infection is healed.
However, if the immune system can not kill off the invaders with 3 - 8 weeks, it then will adapt to the change, leading to chronic inflammatory and infectious diseases.
Dengue virus (DENV) belongs to the Flavivirus genus and is transmitted by Aedes aegypti and Ae. Albopictus mosquitoes, found in tropical and subtropical regions of the world. In severe cases, dengue virus serotype 2 has been found to induce symptoms of severe plasma leakage, severe hemorrhage, and/or severe organ impairment.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the cytotoxic concentration and the inhibitory effect of extracts or fractions from Urtica dioica, Taraxacum officinale, Calea integrifolia and Caesalpinia pulcherrima on the dengue virus serotype 2 (DENV2 replication on the BHK-21 cell line.
According to the tested differentiation,
* The methanolic extracts at 60 °C of T. officinale and U. dioica showed the higher inhibitory effects on DENV2 replication.
* The chemical analysis suggested that the higher activity fraction is found for U. dioica and T. officinale, at the IC50 values of 165.7 ± 3.85 and 126.1 ± 2.80 μg/ml, respectively.
The compounds which exhibited the efficacy of T. officinale were luteolin and caffeoylquinic acid derivatives and quercetin diclycosides compared to the compounds in the active fraction chlorogenic acid, quercetin derivatives and flavonol glycosides (quercetin and kaempferol) in the U. dioica.
Based on the results, researchers suggest, "Two fractions from U. dioica and T. officinale methanolic extracts with anti-dengue activity were found. The compounds present in both fractions were identified, several recognized molecules have demonstrated activity against other viral species".
Taken altogether, dandelion may be considered an antioxidant remedy for the treatment of dengue virus serotype 2, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro by María R. Flores-Ocelotl,1,2,3 Nora H. Rosas-Murrieta,4 Diego A. Moreno,5 Verónica Vallejo-Ruiz,1 Julio Reyes-Leyva,1 Fabiola Domínguez,
2 and Gerardo Santos-López. (PMC)
Similar to bacterial infection, both infections shared common characteristics by spreading through coughing and sneezing by and contact with infected people, especially through kissing and sex.
However, unlike bacteria, a virus replicates only inside the living cells of an organism. Viruses can infect all types of life forms, including humans and microorganisms, such as bacteria and archaea.
Anti-viral effects are the process that certain substances are used to cause the destruction of a virus.
In the acute phase of viral infection, depending on the types of viruses, the viruses after entering the body start to attack the specific host cells. The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, will attack the white blood cells of the immune system,
The viral infection has been known to carry over some different stage, after successfully attaching to the host cell, the virus to release its mRNA into the host cell, leading to the recruit of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.
The white blood cells in the systematic immune response in the acute phase of infection stimulate the production of the proinflammatory cytokines to the site of infection with an aim to protect our body by killing off the invaders.
The battle between the immune white blood cell and viral invaders in most cases an in the flavor of the side of the immune system, the invaders are killed and the infection is healed.
However, if the immune system can not kill off the invaders with 3 - 8 weeks, it then will adapt to the change, leading to chronic inflammatory and infectious diseases.
Dengue virus (DENV) belongs to the Flavivirus genus and is transmitted by Aedes aegypti and Ae. Albopictus mosquitoes, found in tropical and subtropical regions of the world. In severe cases, dengue virus serotype 2 has been found to induce symptoms of severe plasma leakage, severe hemorrhage, and/or severe organ impairment.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the cytotoxic concentration and the inhibitory effect of extracts or fractions from Urtica dioica, Taraxacum officinale, Calea integrifolia and Caesalpinia pulcherrima on the dengue virus serotype 2 (DENV2 replication on the BHK-21 cell line.
According to the tested differentiation,
* The methanolic extracts at 60 °C of T. officinale and U. dioica showed the higher inhibitory effects on DENV2 replication.
* The chemical analysis suggested that the higher activity fraction is found for U. dioica and T. officinale, at the IC50 values of 165.7 ± 3.85 and 126.1 ± 2.80 μg/ml, respectively.
The compounds which exhibited the efficacy of T. officinale were luteolin and caffeoylquinic acid derivatives and quercetin diclycosides compared to the compounds in the active fraction chlorogenic acid, quercetin derivatives and flavonol glycosides (quercetin and kaempferol) in the U. dioica.
Based on the results, researchers suggest, "Two fractions from U. dioica and T. officinale methanolic extracts with anti-dengue activity were found. The compounds present in both fractions were identified, several recognized molecules have demonstrated activity against other viral species".
Taken altogether, dandelion may be considered an antioxidant remedy for the treatment of dengue virus serotype 2, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro by María R. Flores-Ocelotl,1,2,3 Nora H. Rosas-Murrieta,4 Diego A. Moreno,5 Verónica Vallejo-Ruiz,1 Julio Reyes-Leyva,1 Fabiola Domínguez,
2 and Gerardo Santos-López. (PMC)
Friday, July 24, 2020
Herbal Angelica Inhibits the Acute Coronary Syndrome in Patient with Renal Deficiency
The acute coronary syndrome is a medical emergency associated with a range of conditions caused by sudden, reduced blood flow to the heart, leading to heart muscle damage and brain apoptosis depending on the affected location.
Acute coronary syndrome is associated with the severity of buildup of plaque deposits in and on the walls of the coronary arteries.
Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.
Arteries formed a part of blood vessels and circulatory system with function to deliver oxygen and nutrients to heart muscles.
Depending on the severity of the blockage, a complete blockage is life-threatening. Symptoms of the acute coronary syndrome, chest pain or discomfort, pain or discomfort in one or both arms, the jaw, neck, back or stomach, shortness of breath, dizziness, and nausea.
If the chest pain is persistent with no sign of stopping, please call 911 immediately.
The most common treatment of acute coronary syndrome is medicine to reopen the artery. However, in severe cases, angioplasty (a inflate a small balloon) may be necessary.
Traditionally, over many decades, patients with acute coronary syndrome are likely to be treated by oxygen therapy.
Dr. Pankaj Garg in the examing the effects of oxygen therapy on patients with acute coronary syndrome wrote, " However, more recently, there have been many reports of harmful effects of high-flow oxygen in ACS patients where the patient might not be hypoxic".
Anf "High flow oxygen has been shown previously to reduce cardiac output,2 attributes to arterial vasoconstriction3–5 and also to increase systemic vascular resistance.6 More recently, two systematic reviews suggest that the routine use of high-flow oxygen in uncomplicated myocardial infarction may result in greater infarct size and possibly increase the risk of mortality".
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound that inhibits acute coronary syndrome, researchers examined the neuroprotective effects of Chinese herbal medicines in the cardiovascular outcome among patients with the acute coronary syndrome (ACS) and renal insufficiency after the percutaneous coronary intervention (PCI).
The study included population consisted of 215 subjects in the control group who were treated with western medicine standard therapy, and 211 subjects in the treatment group who were treated with Chinese herbal medicines (Fufang Chuanxiong Capsule and Xinyue Capsule) for 6 months.
Participants are from the 5C trial with post-PCI patients suffered from ACS with mild-to-moderate renal insufficiency (30 mL•min-1•1.73 m-2 < estimated glomerular filtration rate≤89 mL•min-1•1.73 m-2).
According to the endpoints including the composite of cardiac death, nonfatal recurrent myocardial infarction, and ischemia-driven revascularization assays, after one year of following up of 2 groups
*There were 16 cases of the primary endpoint in the control group and 6 cases of the primary endpoint in the treatment group with an absolute risk reduction ARR=0.046. elative risk RR= 0.38.
* There were 15 cases of secondary endpoint in the control group and 5 cases of secondary endpoint in the treatment with ARR= 0.041 and RR=0.34
In other words, the treatment of Chinese and Western medicines showed a strong effect in reducing the risk of acute coronary syndrome in patients with renal deficiency.
However, The eGFR levels associated with the renal functioning in the treatment group were significantly higher, compared to the higher levels in the control group.
Based on the findings, researchers said, "Chinese herbal medicines plus western medicine standard therapy improved clinical outcomes in patients with ACS and mild-to-moderate renal insufficiency. Additionally, this study also demonstrated Chinese herbal medicines were useful in deferring the decline of renal function".
Taken altogether, herbal Angelica in combination with other herbal medicines that may be considered a remedy for the treatment of acute coronary syndrome, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention by Zhang DW1, Wang SL2, Wang PL1, Du JP1, Gao ZY1, Wang CL1, Xu H1, Shi DZ. (PubMed)
(2) Oxygen therapy in acute coronary syndrome: current NICE recommendations by Pankaj Garg. (PMC)
Acute coronary syndrome is associated with the severity of buildup of plaque deposits in and on the walls of the coronary arteries.
Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.
Arteries formed a part of blood vessels and circulatory system with function to deliver oxygen and nutrients to heart muscles.
Depending on the severity of the blockage, a complete blockage is life-threatening. Symptoms of the acute coronary syndrome, chest pain or discomfort, pain or discomfort in one or both arms, the jaw, neck, back or stomach, shortness of breath, dizziness, and nausea.
If the chest pain is persistent with no sign of stopping, please call 911 immediately.
The most common treatment of acute coronary syndrome is medicine to reopen the artery. However, in severe cases, angioplasty (a inflate a small balloon) may be necessary.
Traditionally, over many decades, patients with acute coronary syndrome are likely to be treated by oxygen therapy.
Dr. Pankaj Garg in the examing the effects of oxygen therapy on patients with acute coronary syndrome wrote, " However, more recently, there have been many reports of harmful effects of high-flow oxygen in ACS patients where the patient might not be hypoxic".
Anf "High flow oxygen has been shown previously to reduce cardiac output,2 attributes to arterial vasoconstriction3–5 and also to increase systemic vascular resistance.6 More recently, two systematic reviews suggest that the routine use of high-flow oxygen in uncomplicated myocardial infarction may result in greater infarct size and possibly increase the risk of mortality".
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound that inhibits acute coronary syndrome, researchers examined the neuroprotective effects of Chinese herbal medicines in the cardiovascular outcome among patients with the acute coronary syndrome (ACS) and renal insufficiency after the percutaneous coronary intervention (PCI).
The study included population consisted of 215 subjects in the control group who were treated with western medicine standard therapy, and 211 subjects in the treatment group who were treated with Chinese herbal medicines (Fufang Chuanxiong Capsule and Xinyue Capsule) for 6 months.
Participants are from the 5C trial with post-PCI patients suffered from ACS with mild-to-moderate renal insufficiency (30 mL•min-1•1.73 m-2 < estimated glomerular filtration rate≤89 mL•min-1•1.73 m-2).
According to the endpoints including the composite of cardiac death, nonfatal recurrent myocardial infarction, and ischemia-driven revascularization assays, after one year of following up of 2 groups
*There were 16 cases of the primary endpoint in the control group and 6 cases of the primary endpoint in the treatment group with an absolute risk reduction ARR=0.046. elative risk RR= 0.38.
* There were 15 cases of secondary endpoint in the control group and 5 cases of secondary endpoint in the treatment with ARR= 0.041 and RR=0.34
In other words, the treatment of Chinese and Western medicines showed a strong effect in reducing the risk of acute coronary syndrome in patients with renal deficiency.
However, The eGFR levels associated with the renal functioning in the treatment group were significantly higher, compared to the higher levels in the control group.
Based on the findings, researchers said, "Chinese herbal medicines plus western medicine standard therapy improved clinical outcomes in patients with ACS and mild-to-moderate renal insufficiency. Additionally, this study also demonstrated Chinese herbal medicines were useful in deferring the decline of renal function".
Taken altogether, herbal Angelica in combination with other herbal medicines that may be considered a remedy for the treatment of acute coronary syndrome, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention by Zhang DW1, Wang SL2, Wang PL1, Du JP1, Gao ZY1, Wang CL1, Xu H1, Shi DZ. (PubMed)
(2) Oxygen therapy in acute coronary syndrome: current NICE recommendations by Pankaj Garg. (PMC)
Thursday, July 23, 2020
Cranberry Inhibits the Risk and Onset of Oral Cancer
The mouth formed part of the digestive system is an oval-shaped cavity inside the skull that processes 2 main functions of eating and speaking.
Cancer is a group of chronic diseases characterized by cell growth disorderly that starts on the surface of the inner lining tissue of the mouth.
Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva), and the roof of the mouth (palate).
According to the statistics provided by the Canadian Cancer Society, in 2017, 4,700 Canadians were diagnosed with oral cancer, including 3,250 men and 1,450 women. In the same year, the disease also caused the death of 1,250 Canadians.
The exact causes of oral cancer are unknown. Epidemiologically, aging, smoking, excessive alcohol drinking, chewing tobacco and betel nut, long-term use of mouth wash, male ganders are some of the most prevalent factors found in patients with the disease.
Some researchers suggested that poor hygiene that leads to advanced gingivitis may be a major culprit that causes the onset of oral cancer.
Dr. Roshni Ramesh, the lead scientist wrote, "Gingival enlargements are frequently encountered in dental practice. There are different types of gingival enlargements and they vary according to the etiologic factors and pathologic processes that produce them".
And, "Oral cancers especially squamous cell carcinomas present with variations in clinical presentation and the sites affected".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cancer, researchers examined the effect of proanthocyanidins, compounds highly concentrated in dietary cranberries and grapes on oral cancer.
The oral squamous cell carcinoma cell lines, CAL27 and SCC25 were used to compare the effects of cranberry and grape seed extract on phenotypic behaviors of these oral cancers.
According to the tested analysis, administration of cranberry and grape seed extracts, in a dose-dependent manner showed significant inhibition of the proliferation of both oral cancer cell lines.
Proteins associated with the promotion of cancer cell apoptosis were significantly stimulated by the injection of cranberry and grape seed extracts.
The pathways associated with cancer cell adhesion, cell morphology, and cell cycle division were also inhibited by both extracts.
Based on the findings, researchers said, "This study represents one of the first comparative investigations of cranberry and grape seed extracts and their anti-proliferative effects on oral cancers".
And, "cranberry and grape seed extract not only inhibit oral cancer proliferation but also that the mechanism of this inhibition may function by triggering key apoptotic regulators in these cell lines".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of oral cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry and grape seed extracts inhibit the proliferative phenotype of oral squamous cell carcinomas by Chatelain K1, Phippen S, McCabe J, Teeters CA, O'Malley S, Kingsley K. (PubMed)
(2) Oral squamous cell carcinoma masquerading as gingival overgrowth by Roshni Ramesh1 and Arun Sadasivan. (PMC)
Cancer is a group of chronic diseases characterized by cell growth disorderly that starts on the surface of the inner lining tissue of the mouth.
Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva), and the roof of the mouth (palate).
According to the statistics provided by the Canadian Cancer Society, in 2017, 4,700 Canadians were diagnosed with oral cancer, including 3,250 men and 1,450 women. In the same year, the disease also caused the death of 1,250 Canadians.
The exact causes of oral cancer are unknown. Epidemiologically, aging, smoking, excessive alcohol drinking, chewing tobacco and betel nut, long-term use of mouth wash, male ganders are some of the most prevalent factors found in patients with the disease.
Some researchers suggested that poor hygiene that leads to advanced gingivitis may be a major culprit that causes the onset of oral cancer.
Dr. Roshni Ramesh, the lead scientist wrote, "Gingival enlargements are frequently encountered in dental practice. There are different types of gingival enlargements and they vary according to the etiologic factors and pathologic processes that produce them".
And, "Oral cancers especially squamous cell carcinomas present with variations in clinical presentation and the sites affected".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cancer, researchers examined the effect of proanthocyanidins, compounds highly concentrated in dietary cranberries and grapes on oral cancer.
The oral squamous cell carcinoma cell lines, CAL27 and SCC25 were used to compare the effects of cranberry and grape seed extract on phenotypic behaviors of these oral cancers.
According to the tested analysis, administration of cranberry and grape seed extracts, in a dose-dependent manner showed significant inhibition of the proliferation of both oral cancer cell lines.
Proteins associated with the promotion of cancer cell apoptosis were significantly stimulated by the injection of cranberry and grape seed extracts.
The pathways associated with cancer cell adhesion, cell morphology, and cell cycle division were also inhibited by both extracts.
Based on the findings, researchers said, "This study represents one of the first comparative investigations of cranberry and grape seed extracts and their anti-proliferative effects on oral cancers".
And, "cranberry and grape seed extract not only inhibit oral cancer proliferation but also that the mechanism of this inhibition may function by triggering key apoptotic regulators in these cell lines".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of oral cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry and grape seed extracts inhibit the proliferative phenotype of oral squamous cell carcinomas by Chatelain K1, Phippen S, McCabe J, Teeters CA, O'Malley S, Kingsley K. (PubMed)
(2) Oral squamous cell carcinoma masquerading as gingival overgrowth by Roshni Ramesh1 and Arun Sadasivan. (PMC)
Wednesday, July 22, 2020
Herbal Dandelion(Taraxacum officinale) Processes Antiproliferative Activity Against Cancer
Cell proliferation is a radical growth of cells to replace the damage or injury through the cell cycle division.
Cell proliferation is a process and a necessary step for wound healing.
All normal cells undergo cell cycle division to replace the old cells with new cells through a limited cell division.
On the other hand, cancer cells can multiply definitely.
In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.
In the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.
A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.
In the programmed cell death gene, such as BCL-2 induce cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.
In the phytochemicals perspective, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.
Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists compare five different common South European species of Taraxacum (T. obovatum (Willd.) DC., T. marginellum H. Lindb., T. hispanicum H. Lindb., T. lambinonii Soest and T. lacistrum Sahlin) antioxidant and anti-proliferative activity.
According to the dissimilarities between species in LC/MS patterns, T. marginellum demonstrated a strong intracellular antioxidant activity and the cytotoxicity by reducing the expression of ROS.
Compared to the other 3 species, T. marginellum showed the most efficient against the induction of free radicals overexpression in vitro.
Furthermore, in free radical theory, compared to T. marginellum, T. obovatum was the best free radical scavenger and a relevant cytotoxic effect was found in T. lacistrum extract over HeLa and HepG2 cell lines.
Taken altogether, Dandelion may be considered an antioxidant remedy that processes antioxidant and anti-proliferative activity, in a type-dependent manner, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity by Mingarro DM1, Plaza A, Galán A, Vicente JA, Martínez MP, Acero N. (PubMed)
Tuesday, July 21, 2020
Herbal Turmeric Blocks the Onset of Oral Mucositis Caused By the Bacterial Infection
Oral mucositis is considered a side effect in patients who undergo cancer treatment, particularly chemotherapy and radiation.
In cancer, oral mucositis is caused by the reduced function of the immune system to protect the infection of open sores in the mucosa.
However, poor oral or dental health, smoking or chewing tobacco and drinking alcohol, female gender, dehydration, and patients who had previously cancer treatment, have kidney disease are some of the most common risk factors that cause the onset of oral mucositis.
The most common symptoms of oral mucositis are red, shiny, or swollen mouth and gums, sores in the mouth or on the gums or tongue, pain in the mouth or throat, mild burning, or pain when eating food.
Some patients may also experience symptoms of difficulty swallowing or talking, soft, whitish patches or pus in the mouth or on the tongue, particularly the increase of mucus or thicker saliva in the mouth.
Some researchers suggested the onset of oral mucositis in most cases are associated with people with a weakened immune system, including the use of chemotherapy.
Dr. Francesco Chiappelli wrote, "Mucositis is observed in a variety of immunosuppressed patients, but is most often consequential to cancer therapy. It appears as early as the third day of the intervention, and is usually established by Day 7 of treatment".
And, "The precise immune components involved in the etiology of mucositis are unclear, but evidence-based research (EBR) data has shown that applications of granulocyte–macrophage-colony stimulating factor prevent the onset of the exacerbation of oropharyngeal mucositis".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential compound for the treatment of oral mucositis(OM), researchers evaluated the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and/or radiotherapy by searching the database of Cochrane Library, LILACS, LIVIVO, PubMed, Scopus, and Web of Science.
After a two-step selection process, four randomized and one nonrandomized clinical trials were included in the analysis in which 2 studies suggested that topical application of turmeric/curcumin as a gel or mouthwash showed a reduced grade of mucositis, pain, erythema intensity, and ulcerative area.
In other words, the topical application of turmeric or curcumin may be effective in controlling signs and symptoms of oral mucositis in tested patients.
Furthermore, according to the study of 72 golden Syrian hamsters induced mucositis (OM) by 5-fluorouracil (5-FU) for 4 days randomly allocated into four groups: control, placebo, chamomilla, and a mucoadhesive formulation containing curcuminoid (MFC)
* On day 5, all groups exhibited OM
* On day 8, both MFC and chamomilla groups exhibited better-wound healing compared to other groups.
* Moreover, also on day 8, the MFC group demonstrated inhibited protein associated with stimulating new blood vessels for the OM to grow and proinflammatory cytokines to facilitate symptoms of OM, compared to placebo and control group.
Collectively, Dr. Schmidt TR, the lead scientist wrote in the final report, "these findings suggest that MFC has a therapeutic effect on OM, accelerating wound healing through re-epithelization and anti-inflammatory action as modulation of angiogenesis and TGF-β1 expression".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of OM, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of turmeric and curcumin on oral mucositis: A systematic review by Normando AGC1, de Menêses AG2, de Toledo IP1,3, Borges GÁ1, de Lima CL1, Dos Reis PED2, Guerra ENS. (PubMed).
(2) Mucoadhesive formulation containing Curcuma longa L. reduces oral mucositisinduced by 5-fluorouracil in hamsters by Schmidt TR1, Curra M1, Wagner VP1, Martins MAT1,2, de Oliveira AC3, Batista AC4, Valadares MC5, Marreto RN3, Martins MD. (PubMed)
(3) The Molecular Immunology of Mucositis: Implications for Evidence-Based Research in Alternative and Complementary Palliative Treatments by Francesco Chiappelli. (PMC)
In cancer, oral mucositis is caused by the reduced function of the immune system to protect the infection of open sores in the mucosa.
However, poor oral or dental health, smoking or chewing tobacco and drinking alcohol, female gender, dehydration, and patients who had previously cancer treatment, have kidney disease are some of the most common risk factors that cause the onset of oral mucositis.
The most common symptoms of oral mucositis are red, shiny, or swollen mouth and gums, sores in the mouth or on the gums or tongue, pain in the mouth or throat, mild burning, or pain when eating food.
Some patients may also experience symptoms of difficulty swallowing or talking, soft, whitish patches or pus in the mouth or on the tongue, particularly the increase of mucus or thicker saliva in the mouth.
Some researchers suggested the onset of oral mucositis in most cases are associated with people with a weakened immune system, including the use of chemotherapy.
Dr. Francesco Chiappelli wrote, "Mucositis is observed in a variety of immunosuppressed patients, but is most often consequential to cancer therapy. It appears as early as the third day of the intervention, and is usually established by Day 7 of treatment".
And, "The precise immune components involved in the etiology of mucositis are unclear, but evidence-based research (EBR) data has shown that applications of granulocyte–macrophage-colony stimulating factor prevent the onset of the exacerbation of oropharyngeal mucositis".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential compound for the treatment of oral mucositis(OM), researchers evaluated the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and/or radiotherapy by searching the database of Cochrane Library, LILACS, LIVIVO, PubMed, Scopus, and Web of Science.
After a two-step selection process, four randomized and one nonrandomized clinical trials were included in the analysis in which 2 studies suggested that topical application of turmeric/curcumin as a gel or mouthwash showed a reduced grade of mucositis, pain, erythema intensity, and ulcerative area.
In other words, the topical application of turmeric or curcumin may be effective in controlling signs and symptoms of oral mucositis in tested patients.
Furthermore, according to the study of 72 golden Syrian hamsters induced mucositis (OM) by 5-fluorouracil (5-FU) for 4 days randomly allocated into four groups: control, placebo, chamomilla, and a mucoadhesive formulation containing curcuminoid (MFC)
* On day 5, all groups exhibited OM
* On day 8, both MFC and chamomilla groups exhibited better-wound healing compared to other groups.
* Moreover, also on day 8, the MFC group demonstrated inhibited protein associated with stimulating new blood vessels for the OM to grow and proinflammatory cytokines to facilitate symptoms of OM, compared to placebo and control group.
Collectively, Dr. Schmidt TR, the lead scientist wrote in the final report, "these findings suggest that MFC has a therapeutic effect on OM, accelerating wound healing through re-epithelization and anti-inflammatory action as modulation of angiogenesis and TGF-β1 expression".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of OM, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of turmeric and curcumin on oral mucositis: A systematic review by Normando AGC1, de Menêses AG2, de Toledo IP1,3, Borges GÁ1, de Lima CL1, Dos Reis PED2, Guerra ENS. (PubMed).
(2) Mucoadhesive formulation containing Curcuma longa L. reduces oral mucositisinduced by 5-fluorouracil in hamsters by Schmidt TR1, Curra M1, Wagner VP1, Martins MAT1,2, de Oliveira AC3, Batista AC4, Valadares MC5, Marreto RN3, Martins MD. (PubMed)
(3) The Molecular Immunology of Mucositis: Implications for Evidence-Based Research in Alternative and Complementary Palliative Treatments by Francesco Chiappelli. (PMC)
Monday, July 20, 2020
Green Tea Polyphenols (GrTPs), the Anti Female Infertility Bioactive Ingredient, Scientists Find
Scientists may have found a beverage bioactive compound in improving the chance of fertility in female without inducing any side effects, some studies found,
Infertility is a condition characterized by the inability to get pregnant after 12 months of frequent and unprotected sex of a couple. Women who can carry the term of pregnancy are also considered as infertile.
According to the statistic, approximately 8 to 12 percent of couples worldwide experience fertility problems. Between 45 and 50 percent of cases of infertility are attributed to male reproductive problems.
The most common causes of infertility in the female in the US. are aging, medical condition of endometriosis, and polycystic ovarian syndrome (PCOS) which have a strong interruption of the female menstrual cycle, sexually transmitted infections (STIs) and obesity.
Other prevalent risk factors including physical and medical condition, such as blocked fallopian tubes due to pelvic inflammatory disease, and physical problems with the uterus and diabetes, long-term intakes of a certain medicine, such as anti-inflammatory drug and hormone imbalance that affect the menstrual cycle
Genetic preposition such as The HOXA13 gene. The only one single gene disorder has been shown to affect uterine development in infertile females.
Age, smoking, use of illicit drugs, excessive alcohol drinking, and long-term exposure to chemicals are the common causes of female infertility.
In term of diet, researchers at the Harvard T.H. Chan School of Public Health in the study "Diet and female fertility: doctor, what should I eat?" wrote, "According to existing data, women trying to achieve pregnancy are encouraged to increase consumption of whole grains, omega-3 fatty acids, fish, and soy and to reduce consumption of trans fats and red meat. In addition, a daily multivitamin that contains folic acid before and during pregnancy may not only prevent birth defects but also improve the chance of achieving and maintaining a pregnancy".
These results suggested that women who follow the diet with high in saturated and trans fat, intake of a large amount of red meat and processed food, and less in fruits, nuts, and vegetables are at a higher risk of infertility or of carrying the pregnancy to full term.
In the concerns of oxygen species (ROS), which are produced during cellular oxidation may reduce the chance of conception, researchers at the joint study led by the Uniwersytet Medyczny w Łodzi. launched an investigation to examine whether increased production of reactive oxygen species is an important factor in the etiopathogenesis of pregnancy and affects female reproduction.
Before the application of green tea s (GrTPs) researchers found that oxidative stress caused by overexpression of free radicals may damage the oocytes and may impair their fertilization capacity.
The increased ROS levels probably are the results of antioxidant enzymes produced by the tested subjects being suppressed due to some unknown mechanisms.
Oxidative stress may also lead to embryo fragmentation and formation of numerous developmental abnormalities and is regarded to be one of the important reasons for spontaneous and recurrent miscarriage
Oral administered green tea polyphenols (GrTPs) inhibits the overexpression of ROS showed to restore the embryo fragmentation and formation of numerous developmental abnormalities and increase the quality of female gametes, mostly via the capability of catechins to reduce ROS production.
Further analysis also suggested that GrTPs processed antioxidant properties that only restores the health of oocytes caused by overexpression of ROS but also improves age-related decline in female fertility rate, and gamete quality.
These unique properties of green tea catechins in improving the female reproductive health suggested green tea polyphenols (GrTPs) may be considered a functional food in protecting against the damage of the oocytes and their fertilization capacity and the integrity of embryo.
Dr, Rahman SU, the lead scientist at the final report, said, "the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals".
Additionally, in the concerns of the Reactive oxygen species (ROS) that may increase the risk of female infertility, researchers launched an investigation to examine whether green tea catechins protect the female gametes over the expression of ROS.
After taking into account levels of oxidative stress before and after application of green tea catechin, researchers wrote,
* Epigallocatechin-3-gallate (EGCG), a major bioactive compound in green tea inhibited the expression of ROS in facilitating the damage of female gametes through to its strong antioxidant activity.
* Green tea catechins potentially improves the oocyte maturation and may inhibit in-vitro maturation of the oocyte
Dr. Roychoudhury S, the lead author said, " (These results furtherly confirmed) the potential roles of green tea catechins on oxidative stress in male and female reproduction and fertility".
Taken altogether, Green tea polyphenols (GrTPs) may be considered an adjunct therapy in the protection of the female gametes and oocyte maturation against the onset of infertility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diet and female fertility: doctor, what should I eat? by Chiu YH1, Chavarro JE2, Souter I. (PubMed)
(2) Potential role of green tea catechins in the management of oxidative stress-associated infertility by Roychoudhury S1, Agarwal A2, Virk G3, Cho CL. (PubMed)
Infertility is a condition characterized by the inability to get pregnant after 12 months of frequent and unprotected sex of a couple. Women who can carry the term of pregnancy are also considered as infertile.
According to the statistic, approximately 8 to 12 percent of couples worldwide experience fertility problems. Between 45 and 50 percent of cases of infertility are attributed to male reproductive problems.
The most common causes of infertility in the female in the US. are aging, medical condition of endometriosis, and polycystic ovarian syndrome (PCOS) which have a strong interruption of the female menstrual cycle, sexually transmitted infections (STIs) and obesity.
Other prevalent risk factors including physical and medical condition, such as blocked fallopian tubes due to pelvic inflammatory disease, and physical problems with the uterus and diabetes, long-term intakes of a certain medicine, such as anti-inflammatory drug and hormone imbalance that affect the menstrual cycle
Genetic preposition such as The HOXA13 gene. The only one single gene disorder has been shown to affect uterine development in infertile females.
Age, smoking, use of illicit drugs, excessive alcohol drinking, and long-term exposure to chemicals are the common causes of female infertility.
In term of diet, researchers at the Harvard T.H. Chan School of Public Health in the study "Diet and female fertility: doctor, what should I eat?" wrote, "According to existing data, women trying to achieve pregnancy are encouraged to increase consumption of whole grains, omega-3 fatty acids, fish, and soy and to reduce consumption of trans fats and red meat. In addition, a daily multivitamin that contains folic acid before and during pregnancy may not only prevent birth defects but also improve the chance of achieving and maintaining a pregnancy".
These results suggested that women who follow the diet with high in saturated and trans fat, intake of a large amount of red meat and processed food, and less in fruits, nuts, and vegetables are at a higher risk of infertility or of carrying the pregnancy to full term.
In the concerns of oxygen species (ROS), which are produced during cellular oxidation may reduce the chance of conception, researchers at the joint study led by the Uniwersytet Medyczny w Łodzi. launched an investigation to examine whether increased production of reactive oxygen species is an important factor in the etiopathogenesis of pregnancy and affects female reproduction.
Before the application of green tea s (GrTPs) researchers found that oxidative stress caused by overexpression of free radicals may damage the oocytes and may impair their fertilization capacity.
The increased ROS levels probably are the results of antioxidant enzymes produced by the tested subjects being suppressed due to some unknown mechanisms.
Oxidative stress may also lead to embryo fragmentation and formation of numerous developmental abnormalities and is regarded to be one of the important reasons for spontaneous and recurrent miscarriage
Oral administered green tea polyphenols (GrTPs) inhibits the overexpression of ROS showed to restore the embryo fragmentation and formation of numerous developmental abnormalities and increase the quality of female gametes, mostly via the capability of catechins to reduce ROS production.
Further analysis also suggested that GrTPs processed antioxidant properties that only restores the health of oocytes caused by overexpression of ROS but also improves age-related decline in female fertility rate, and gamete quality.
These unique properties of green tea catechins in improving the female reproductive health suggested green tea polyphenols (GrTPs) may be considered a functional food in protecting against the damage of the oocytes and their fertilization capacity and the integrity of embryo.
Dr, Rahman SU, the lead scientist at the final report, said, "the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals".
Additionally, in the concerns of the Reactive oxygen species (ROS) that may increase the risk of female infertility, researchers launched an investigation to examine whether green tea catechins protect the female gametes over the expression of ROS.
After taking into account levels of oxidative stress before and after application of green tea catechin, researchers wrote,
* Epigallocatechin-3-gallate (EGCG), a major bioactive compound in green tea inhibited the expression of ROS in facilitating the damage of female gametes through to its strong antioxidant activity.
* Green tea catechins potentially improves the oocyte maturation and may inhibit in-vitro maturation of the oocyte
Dr. Roychoudhury S, the lead author said, " (These results furtherly confirmed) the potential roles of green tea catechins on oxidative stress in male and female reproduction and fertility".
Taken altogether, Green tea polyphenols (GrTPs) may be considered an adjunct therapy in the protection of the female gametes and oocyte maturation against the onset of infertility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diet and female fertility: doctor, what should I eat? by Chiu YH1, Chavarro JE2, Souter I. (PubMed)
(2) Potential role of green tea catechins in the management of oxidative stress-associated infertility by Roychoudhury S1, Agarwal A2, Virk G3, Cho CL. (PubMed)
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