Ecchymosis is a discoloration of the skin caused by the bleeding underneath the skin, typically in bruising.
Most cases of ecchymosis are results in which the blood vessels near the surface of the skin burst, particularly in the impact of an injury.
In other words, ecchymosis is associated with blood vessel leaks, and the blood is accumulated under the skin.
The discoloring of the skin is also involved in the clotting factors, that stop the bleeding so that the tissue starts healing.
The progression of ecchymosis is gone through a certain stage from red or purple to black or blue
to brown and to yellow.
Certain medications have been found to induce ecchymosis including:
* Blood thinners, such as aspirin or warfarin
*Antibiotics such as cephalexin, cefaclor, and cefuroxime-axetil can cause ecchymosis by inducing low platelet count
* Corticosteroids
According to the study from the University College Hospital, easy bruising tended to be older (61 vs 52 yrs), on higher daily dosages (1,388 vs 1,067 micrograms), particularly in the long term inhaled corticosteroids users.
Most cases of ecchymosis usually heal on their own within two to three weeks. Most common medications used for the treatment of ecchymosis are pain relievers.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of ecchymosis, researchers examined the effects of bromelain on ecchymosis postprocedure unwanted effects.
In the reconfirm the effect of bromelain used internationally by physicians on limit ecchymosis secondary to cosmetic, laser, and surgical skin procedures, researchers reviewed the published literature and provide evidence-based recommendations on bromelain for prevention and treatment of postprocedure ecchymosis.
The search on the computerized bibliographic databases Medline, EMBASE, Scopus, and CINAHL on March 23, 2015, identified 7 clinical trials that study the effect of oral bromelain in the prevention and/or treatment of postprocedure ecchymosis compared to no studies that use topical bromelain for the treatment of ecchymosis.
Based on the results, 5 out of 7 randomized controlled trials reported improvement postprocedure ecchymosis in the bromelain-treated group.
Taken altogether, bromelain may be considered a remedy for the treatment of postprocedure ecchymosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature by Ho D1, Jagdeo J, Waldorf HA. (PubMed)
(2) Easy bruising as a side-effect of inhaled corticosteroids by Mak VH1, Melchor R, Spiro SG. (PubMed)
Friday, August 21, 2020
Thursday, August 20, 2020
How to Treat Painful Primary Dysmenorrhea Quickly and Permanently, According to PubMed
Adding a portion of fennel in your daily diet may have a potential and positive effect in reduced pain caused by sensory neurons stimulus in women with primary dysmenorrhea, some scientists suggested.
Antinociceptive activity is an action or process of blocking the painful or injurious stimulus by sensory neurons.
The results of the investigation were carried out by numbers of respectable institutes, including the Babol University of Medical Sciences and Health Services and details of the experiment were published on the online medical library.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In order to compare the effect of the combination of fennel extract/vitamin E with ibuprofen on the intensity of pain in primary dysmenorrhea among the students of Tabriz city in 2007-2009, researchers od the joint study lead by the Kosar Department of Shahid Motahhary Hospital carried out an investigation of 68 students from Medical and Tabriz universities, who were living in the dormitory, suffering from primary dysmenorrhea.
All participants were randomly divided into two groups of 34 students each (the two groups used combination of fennel extract/vitamin E and ibuprofen cross-over form in the 2 months).
Application of the combination displayed a mean of peak pain intensity in the first, second, third, sixth, and forty-eight hours in the group was significantly lower than the group that had used ibuprofen.
Also, a combination of fennel extract/vitamin E was more effective than ibuprofen in the first hour (P < 0.03) and second hour (P < 0.04), according to the Visual Analogue Scale (VAS) tool for ranking the intensity of the pain.
These results suggested that fennel and vitamin E combination was more efficacy in blocking the neuron in transmitting pain caused by overexpression prostaglandin hormone in the induction of abdominal muscle constriction in comparison to conventional medicine ibuprofen.
Dr. Nasehi M, the lead author, after taking into account other co and confounders said, "Combination of fennel extract/vitamin E is effective on decreasing the intensity of pain of primary dysmenorrhea, and it is advised to those who cannot use chemical drugs".
In a separate study to investigate the effect of fennel used alone on primary dysmenorrhea symptoms and menorrhea duration, 80 female students satisfied the criteria and guidelines were randomly divided into two groups of intervention (n = 40) and control (n = 40).
The intervention group was given one soft capsule Fennel (30 mg) every 4 hours, 3 days before menstruation till the 5th day, and continued for 3 months. The control group received no medication.
According to the result of the experiments, the fennel treated group exerted a significant decrease of the mean of nausea intensity and weakness from 1.93, and 2.88 after 3 months, in comparison to the control group from 2.37, 6.65 in the control group.
Also in compared to the control group, the fennel group reduced the duration of the menstrual period after two and three months of use.
Moreover, Fennel treated group demonstrated a strong improvement of quality and feelings of well-being after 1 and 3 months.
Taken together, fennel may be considered as a functional food for the treatment of Primary Dysmenorrhea without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The effect of fennel on pain quality, symptoms, and menstrual duration in primary dysmenorrhea by Ghodsi Z1, Asltoghiri M2.(PubMed)
(2) Comparison of the effectiveness of combination of fennel extract/vitamin E with ibuprofen on the pain intensity in students with primary dysmenorrhea by Nasehi M1, Sehhatie F2, Zamanzadeh V3, Delazar A4, Javadzadeh Y5, Chongheralu BM6.(PubMed)
Antinociceptive activity is an action or process of blocking the painful or injurious stimulus by sensory neurons.
The results of the investigation were carried out by numbers of respectable institutes, including the Babol University of Medical Sciences and Health Services and details of the experiment were published on the online medical library.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In order to compare the effect of the combination of fennel extract/vitamin E with ibuprofen on the intensity of pain in primary dysmenorrhea among the students of Tabriz city in 2007-2009, researchers od the joint study lead by the Kosar Department of Shahid Motahhary Hospital carried out an investigation of 68 students from Medical and Tabriz universities, who were living in the dormitory, suffering from primary dysmenorrhea.
All participants were randomly divided into two groups of 34 students each (the two groups used combination of fennel extract/vitamin E and ibuprofen cross-over form in the 2 months).
Application of the combination displayed a mean of peak pain intensity in the first, second, third, sixth, and forty-eight hours in the group was significantly lower than the group that had used ibuprofen.
Also, a combination of fennel extract/vitamin E was more effective than ibuprofen in the first hour (P < 0.03) and second hour (P < 0.04), according to the Visual Analogue Scale (VAS) tool for ranking the intensity of the pain.
These results suggested that fennel and vitamin E combination was more efficacy in blocking the neuron in transmitting pain caused by overexpression prostaglandin hormone in the induction of abdominal muscle constriction in comparison to conventional medicine ibuprofen.
Dr. Nasehi M, the lead author, after taking into account other co and confounders said, "Combination of fennel extract/vitamin E is effective on decreasing the intensity of pain of primary dysmenorrhea, and it is advised to those who cannot use chemical drugs".
In a separate study to investigate the effect of fennel used alone on primary dysmenorrhea symptoms and menorrhea duration, 80 female students satisfied the criteria and guidelines were randomly divided into two groups of intervention (n = 40) and control (n = 40).
The intervention group was given one soft capsule Fennel (30 mg) every 4 hours, 3 days before menstruation till the 5th day, and continued for 3 months. The control group received no medication.
According to the result of the experiments, the fennel treated group exerted a significant decrease of the mean of nausea intensity and weakness from 1.93, and 2.88 after 3 months, in comparison to the control group from 2.37, 6.65 in the control group.
Also in compared to the control group, the fennel group reduced the duration of the menstrual period after two and three months of use.
Moreover, Fennel treated group demonstrated a strong improvement of quality and feelings of well-being after 1 and 3 months.
Taken together, fennel may be considered as a functional food for the treatment of Primary Dysmenorrhea without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The effect of fennel on pain quality, symptoms, and menstrual duration in primary dysmenorrhea by Ghodsi Z1, Asltoghiri M2.(PubMed)
(2) Comparison of the effectiveness of combination of fennel extract/vitamin E with ibuprofen on the pain intensity in students with primary dysmenorrhea by Nasehi M1, Sehhatie F2, Zamanzadeh V3, Delazar A4, Javadzadeh Y5, Chongheralu BM6.(PubMed)
Wednesday, August 19, 2020
The Science Base of Herbs in Induced Weight Loss and Weight Maintenance
Overweight and obesity have reached epidemic proportions in many countries, causing economic burden in increased absentees in the workplaces and funding for the health care system in dealing with obesity-related disorders such as diabetes, hypertension, and cardiovascular diseases(1).
One of six Malaysian are either extremely overweight or obese, according to Datin Paduka Santha Kumari, chairman of the Selangor branch of the Malaysian Diabetes Association and the global health observatory, at least 2.8 million people die each year as a result of being overweight or obese, and an estimated 35.8 million (2.3%) of the global burden of disease is caused by overweight or obesity(2).
Epidemiological studies, linking herbal medicine, foods, and vitamins in preventing and treating these diseases have been inconclusive(a)
Some researchers suggested that the intake of certain herbal medicine may enhance appetite suppression.
According to the Georgetown University Medical Center, the appetite of average daily food intake was decreased only with the herbal formulation, regardless number of single-ingredient in comparison to the effectiveness among herbal formulation and a commonly available(3).
Other researchers insisted that using herbs and supplements to induce weight loss should be taken with care, as a considerable number of reports have been published on hepatotoxicity associated to intake of herbal products(4)(5)(6)(7).
The College of Medicine, The Ohio State University insisted that various dietary, lifestyle and psychological factors are involved in the etiology of Prameha, in initiated disturbances of fat and carbohydrate metabolism in overweight and obese(8), without effective management, obtaining a workable weight loss plan may be extremely difficult.
1. Ginseng
Ginseng is a slow-growing perennial plant with fleshy roots, the genus Panax, belongings to the family Araliaceae. Depending on the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root)(14).
In 10 obese middle-aged Korean women who took Panax ginseng extracts for 8 wk, showed effectively in influence on gut microbiota in promoting weight loss but depending to the composition of gut microbiota prior to ginseng intake(15).
In mice fed with a high-fat diet, ginseng saponin and ginsenosides exerted anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signaling in cell culture systems and abnormal physiology of leptin, insulin, and adiponectin in energy and lipid metabolism(16).
2. Zingiber Officinale(Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.(17).
According to the Tehran University of Medical Sciences, Slimax (extract of several plants including Zingiber officinale and Bofutsushosan) showed a significant decrease in body weight or inhibited weight gain(18).
Application of composition of a multi-ingredients supplement containing primarily raspberry ketone, caffeine, capsaicin, garlic, ginger, and Citrus aurantium, also improved body composition, waist and hip girth, in an eight-week diet and exercise weight loss program(19).
In a comparison of the weight loss effect of Orlistat, a pharmacological agent promoting weight loss, injection of ginger (Zingiber officinale Roscoe, Zingiberacae) in male albino rats induced a great ability to reduce body weight without inhibiting pancreatic lipase level, or affected bilirubin concentration, and increased peroxisomal catalase level and HDL-cholesterol(20).
3. Cissus quadrangularis (CQ)
Cissus quadrangularis is an ancient herb used to treat a variety of indications, belongings to the grape family, probably native to India or Sri Lanka.
In a randomized, double-blind, placebo-controlled design study involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19-50). conducted by the University of Yaoundé I, Cissus quadrangularis, application of cissus quadrangularis displayed a statistically significant net reduction in weight and central obesity, as well as normalized metabolic syndrome(21).
In a comparison of the efficacy of Cissus quadrangularis-only and Cissusquadrangularis/Irvingia gabonensis combination, on weight loss in overweight and obese human subjects, cissus quadrangularis-only group showed significant reductions on all variables in compared to the placebo group, but lower effects in compared to the cissus quadrangularis/Irvingia gabonensis combination group(22)
Intake of CQR-300, a proprietary extract of Cissusquadrangularis, also demonstrated a significant deceased weight and blood glucose levels, serum lipids, thus improving cardiovascular risk factors, according to the University of Yaoundé I,(23).
4. Sambucus nigra
Elder also was known as Common Elder, is a shrub or small tree of the genus Sambucus of 30 specie, belongings to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere, used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.
The composition of supplement with Sambucus nigra and Asparagus officinalis study expressed effectiveness in reduced weight, blood pressure, enhanced physical and emotional well-being, and quality of life(24).
The Tehran University of Medical Sciences, Sambucus nigra study, also demonstrated a significant decrease in body weight in numbers of animal studies(25).
5. Asparagus officinalis
Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia, used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties(26).
Asparagus officinalis L. powder tablets provided 19 mg saponins per day in overweight and obese subjects reduced mean weight, blood pressure, and enhanced physical and emotional well-being and the quality of life with the rate of very good or good in most of the completers(27).
In 12 weeks supplementation of a botanical extract-based weight loss formula, including Asparagus, researchers at the Poznan University of Medical Science indicated that the formula exerts a significant change of the body composition improvement index (BCI), induces greater weight loss than placebo, probably through a concurrently performed exercise program recommended strategy for lifestyle modification(28).
6. Slimax
Slimax (extract of several plants including officinale and Bofutsushosan), in the reviews of the database of studies published, researchers showed that intake of Slimax indices a significant decrease in body weight(29).
In 41 animal studies, the formula was found to be effective in significant induced weight loss or inhibited weight gain(29).
Taken altogether, the above herbs may be effective in enhanced weight loss through suppression of appetite and improvement of syndrome induced by overweight and obesity. However, intake of herbal supplements and composition should only be prescribed by herbal doctors.
FDA banned Ephera (Ma Huang) weight loss products in 2004
[Ma Huang is also known as ephedra. The acrid, slightly bitter, and warm herb has been used in TCM to promote urination and sweating and rid of cold, soothe wheezing asthma, ...., by enhancing the functions of lung and bladder channels(9).
According to Dongguk University, certain chemicals found in Ephera showed an association with changes of BW and BMI through alteration of gut microbiota varied by indigenous microbiota of tested subject(10).
The combined study of a low-calorie diet and Ephera, in 125 otherwise healthy obese women, showed effectively in reducing BMI. RMR change not compensated for by the herbal medicines tried.
Resting metabolic rate (RMR) change seemed to be affected by constitution and body composition rather than by medicine(11). The Dongeui University study of composition GGEx18( Laminaria japonica, Rheum palmatum, and Ephedra sinica) in high fat diet-induced obese mice suggested that GGEx18 improves obesity through skeletal muscle AMPK and AMPK-stimulated expression of PPARα and its target enzymes for fatty acid oxidation, through inhibited lipid accumulation, and similar activation of genes(12).
Please note that due to its adverse reactions of palpitations, stress, headache and insomnia and stroke, heart attacks, cardiac arrhythmias, seizures, and psychotic effect, the FDA banned the product on 2004, the Dutch Inspectorate for Health Care and the Ministry of Health in Canada have recently requested a market recall of some ephedrine-containing herbal products in response to above adverse reactions. In the Netherlands, the status of Ephedra-containing products is currently reconsidered(13)]
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)
(2) Obesity - Situation and trends(WHO)
(3) Influence of a combination of herbs on appetite suppression and weight loss in rats by Talpur NA1, Echard BW, Manohar V, Preuss HG.(PubMed)
(4) [Hepatotoxicity induced by herbs and medicines used to induce weight loss].[Article in Spanish]by Herrera S1, Bruguera M.(PubMed)
(5) A case report of adult lead toxicity following use of Ayurvedic herbal medication by Breeher L1, Gerr F, Fuortes L.(PubMed)
(6) [Chronic lead intoxication associated with Ayurvedic medication].[Article in Dutch] by Kanen BL1, Perenboom RM.(PubMed)
(7) Potential toxicity of caffeine when used as a dietary supplement for weight loss by Pendleton M1, Brown S, Thomas C, Odle B.(PubMed)
(8) Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial by Hackman RM1, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL.(PubMed)
(9) Ma Huang(Popular Chinese herbs)
(10) Prameha in Ayurveda: correlation with obesity, metabolic syndrome, and diabetes mellitus. Part 2--management of Prameha by Sharma H1, Chandola HM.(PubMed)
(11) Effect of herbal Ephedra sinica and Evodia rutaecarpa on body composition and resting metabolic rate: a randomized, double-blind clinical trial in Korean premenopausal women by Kim HJ1, Park JM, Kim JA, Ko BP(PubMed)
(12) The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα by Shin SS1, Park D, Lee HY, Hong Y, Choi J, Oh J, Lee H, Lee HR, Kim MR, Shen ZB, Cui HH, Yoon M.(PubMed)
(13) [Ephedrine and ephedra in weight loss products and other preparations].[Article in Dutch] by van der Hooft CS1, Stricker BH.(PubMed)
(14) Ginseng, Asian (Panax ginseng) and Ginseng, North America(Popular Chinese Herbs)
(15) Influence of Panax ginseng on obesity and gut microbiota in obese middle-aged Korean women by Song MY1, Kim BS2, Kim H(PubMed)
(16) Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet by Song YB1, An YR, Kim SJ, Park HW, Jung JW, Kyung JS, Hwang SY, Kim YS.(PubMed)
(17) Popular #Herbs - #Ginger (Zingiber officinale)(Popular Chinese herbs)
(18) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity by Hasani-Ranjbar S1, Nayebi N, Larijani B, Abdollahi M.(PubMed)
(19) Eight weeks of supplementation with a multi-ingredient weight lossproduct enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women by Lopez HL1, Ziegenfuss TN, Hofheins JE, Habowski SM, Arent SM, Weir JP, Ferrando AA.(PubMed)
(20) Comparative evaluation of the efficacy of ginger and orlistat on obesity management, pancreatic lipase and liver peroxisomal catalase enzyme in male albino rats by Mahmoud RH1, Elnour WA.(PubMed)
(21) The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome by Oben J1, Kuate D, Agbor G, Momo C, Talla X.(PubMed)
(22) The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. by Oben JE1, Ngondi JL, Momo CN, Agbor GA, Sobgui CS.(PubMed)
(23) The effect of Cissus quadrangularis (CQR-300) and a Cissusformulation (CORE) on obesity and obesity-induced oxidative stress by Oben JE1, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA.(PubMed)
(24) An observational study and quantification of the actives in a supplement with Sambucus nigra and Asparagus officinalis used for weight reduction by Chrubasik C1, Maier T, Dawid C, Torda T, Schieber A, Hofmann T, Chrubasik S.(PubMed)
(25) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity by Hasani-Ranjbar S1, Nayebi N, Larijani B, Abdollahi M(PubMed)
(26) #Healthy #Foods - Vegetables - Asparagus (Asparagus officinalis)(health tips for better living and living health)
(27) An observational study and quantification of the actives in a supplement with Sambucus nigra and Asparagus officinalis used for weight reduction by Chrubasik C1, Maier T, Dawid C, Torda T, Schieber A, Hofmann T, Chrubasik S.(PubMed)
(28) Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects--a randomised double-blind placebo-controlled clinical trial by Opala T1, Rzymski P, Pischel I, Wilczak M, Wozniak J.(PubMed)
(29) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity by Hasani-Ranjbar S1, Nayebi N, Larijani B, Abdollahi M.(PubMed)
One of six Malaysian are either extremely overweight or obese, according to Datin Paduka Santha Kumari, chairman of the Selangor branch of the Malaysian Diabetes Association and the global health observatory, at least 2.8 million people die each year as a result of being overweight or obese, and an estimated 35.8 million (2.3%) of the global burden of disease is caused by overweight or obesity(2).
Epidemiological studies, linking herbal medicine, foods, and vitamins in preventing and treating these diseases have been inconclusive(a)
Some researchers suggested that the intake of certain herbal medicine may enhance appetite suppression.
According to the Georgetown University Medical Center, the appetite of average daily food intake was decreased only with the herbal formulation, regardless number of single-ingredient in comparison to the effectiveness among herbal formulation and a commonly available(3).
Other researchers insisted that using herbs and supplements to induce weight loss should be taken with care, as a considerable number of reports have been published on hepatotoxicity associated to intake of herbal products(4)(5)(6)(7).
The College of Medicine, The Ohio State University insisted that various dietary, lifestyle and psychological factors are involved in the etiology of Prameha, in initiated disturbances of fat and carbohydrate metabolism in overweight and obese(8), without effective management, obtaining a workable weight loss plan may be extremely difficult.
1. Ginseng
Ginseng is a slow-growing perennial plant with fleshy roots, the genus Panax, belongings to the family Araliaceae. Depending on the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root)(14).
In 10 obese middle-aged Korean women who took Panax ginseng extracts for 8 wk, showed effectively in influence on gut microbiota in promoting weight loss but depending to the composition of gut microbiota prior to ginseng intake(15).
In mice fed with a high-fat diet, ginseng saponin and ginsenosides exerted anti-obesity effects via the modulation of physiological lipid metabolism in vivo or intracellular signaling in cell culture systems and abnormal physiology of leptin, insulin, and adiponectin in energy and lipid metabolism(16).
2. Zingiber Officinale(Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.(17).
According to the Tehran University of Medical Sciences, Slimax (extract of several plants including Zingiber officinale and Bofutsushosan) showed a significant decrease in body weight or inhibited weight gain(18).
Application of composition of a multi-ingredients supplement containing primarily raspberry ketone, caffeine, capsaicin, garlic, ginger, and Citrus aurantium, also improved body composition, waist and hip girth, in an eight-week diet and exercise weight loss program(19).
In a comparison of the weight loss effect of Orlistat, a pharmacological agent promoting weight loss, injection of ginger (Zingiber officinale Roscoe, Zingiberacae) in male albino rats induced a great ability to reduce body weight without inhibiting pancreatic lipase level, or affected bilirubin concentration, and increased peroxisomal catalase level and HDL-cholesterol(20).
3. Cissus quadrangularis (CQ)
Cissus quadrangularis is an ancient herb used to treat a variety of indications, belongings to the grape family, probably native to India or Sri Lanka.
In a randomized, double-blind, placebo-controlled design study involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19-50). conducted by the University of Yaoundé I, Cissus quadrangularis, application of cissus quadrangularis displayed a statistically significant net reduction in weight and central obesity, as well as normalized metabolic syndrome(21).
In a comparison of the efficacy of Cissus quadrangularis-only and Cissusquadrangularis/Irvingia gabonensis combination, on weight loss in overweight and obese human subjects, cissus quadrangularis-only group showed significant reductions on all variables in compared to the placebo group, but lower effects in compared to the cissus quadrangularis/Irvingia gabonensis combination group(22)
Intake of CQR-300, a proprietary extract of Cissusquadrangularis, also demonstrated a significant deceased weight and blood glucose levels, serum lipids, thus improving cardiovascular risk factors, according to the University of Yaoundé I,(23).
4. Sambucus nigra
Elder also was known as Common Elder, is a shrub or small tree of the genus Sambucus of 30 specie, belongings to the family Adoxaceae, native to the temperate-to-subtropical regions of both the Northern Hemisphere and the Southern Hemisphere, used in traditional and herbal medicine to treat constipation, colic, diarrhea, colds, flu, bronchial and upper-respiratory, irritation of the skin, rheumatism, etc.
The composition of supplement with Sambucus nigra and Asparagus officinalis study expressed effectiveness in reduced weight, blood pressure, enhanced physical and emotional well-being, and quality of life(24).
The Tehran University of Medical Sciences, Sambucus nigra study, also demonstrated a significant decrease in body weight in numbers of animal studies(25).
5. Asparagus officinalis
Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and western Asia, used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties(26).
Asparagus officinalis L. powder tablets provided 19 mg saponins per day in overweight and obese subjects reduced mean weight, blood pressure, and enhanced physical and emotional well-being and the quality of life with the rate of very good or good in most of the completers(27).
In 12 weeks supplementation of a botanical extract-based weight loss formula, including Asparagus, researchers at the Poznan University of Medical Science indicated that the formula exerts a significant change of the body composition improvement index (BCI), induces greater weight loss than placebo, probably through a concurrently performed exercise program recommended strategy for lifestyle modification(28).
6. Slimax
Slimax (extract of several plants including officinale and Bofutsushosan), in the reviews of the database of studies published, researchers showed that intake of Slimax indices a significant decrease in body weight(29).
In 41 animal studies, the formula was found to be effective in significant induced weight loss or inhibited weight gain(29).
Taken altogether, the above herbs may be effective in enhanced weight loss through suppression of appetite and improvement of syndrome induced by overweight and obesity. However, intake of herbal supplements and composition should only be prescribed by herbal doctors.
FDA banned Ephera (Ma Huang) weight loss products in 2004
[Ma Huang is also known as ephedra. The acrid, slightly bitter, and warm herb has been used in TCM to promote urination and sweating and rid of cold, soothe wheezing asthma, ...., by enhancing the functions of lung and bladder channels(9).
According to Dongguk University, certain chemicals found in Ephera showed an association with changes of BW and BMI through alteration of gut microbiota varied by indigenous microbiota of tested subject(10).
The combined study of a low-calorie diet and Ephera, in 125 otherwise healthy obese women, showed effectively in reducing BMI. RMR change not compensated for by the herbal medicines tried.
Resting metabolic rate (RMR) change seemed to be affected by constitution and body composition rather than by medicine(11). The Dongeui University study of composition GGEx18( Laminaria japonica, Rheum palmatum, and Ephedra sinica) in high fat diet-induced obese mice suggested that GGEx18 improves obesity through skeletal muscle AMPK and AMPK-stimulated expression of PPARα and its target enzymes for fatty acid oxidation, through inhibited lipid accumulation, and similar activation of genes(12).
Please note that due to its adverse reactions of palpitations, stress, headache and insomnia and stroke, heart attacks, cardiac arrhythmias, seizures, and psychotic effect, the FDA banned the product on 2004, the Dutch Inspectorate for Health Care and the Ministry of Health in Canada have recently requested a market recall of some ephedrine-containing herbal products in response to above adverse reactions. In the Netherlands, the status of Ephedra-containing products is currently reconsidered(13)]
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Rising Burden of Obesity in Asia by Ambady Ramachandran and Chamukuttan Snehalatha(Journey of Obesity)
(2) Obesity - Situation and trends(WHO)
(3) Influence of a combination of herbs on appetite suppression and weight loss in rats by Talpur NA1, Echard BW, Manohar V, Preuss HG.(PubMed)
(4) [Hepatotoxicity induced by herbs and medicines used to induce weight loss].[Article in Spanish]by Herrera S1, Bruguera M.(PubMed)
(5) A case report of adult lead toxicity following use of Ayurvedic herbal medication by Breeher L1, Gerr F, Fuortes L.(PubMed)
(6) [Chronic lead intoxication associated with Ayurvedic medication].[Article in Dutch] by Kanen BL1, Perenboom RM.(PubMed)
(7) Potential toxicity of caffeine when used as a dietary supplement for weight loss by Pendleton M1, Brown S, Thomas C, Odle B.(PubMed)
(8) Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial by Hackman RM1, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, Stohs SJ, Stern JS, Keen CL.(PubMed)
(9) Ma Huang(Popular Chinese herbs)
(10) Prameha in Ayurveda: correlation with obesity, metabolic syndrome, and diabetes mellitus. Part 2--management of Prameha by Sharma H1, Chandola HM.(PubMed)
(11) Effect of herbal Ephedra sinica and Evodia rutaecarpa on body composition and resting metabolic rate: a randomized, double-blind clinical trial in Korean premenopausal women by Kim HJ1, Park JM, Kim JA, Ko BP(PubMed)
(12) The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα by Shin SS1, Park D, Lee HY, Hong Y, Choi J, Oh J, Lee H, Lee HR, Kim MR, Shen ZB, Cui HH, Yoon M.(PubMed)
(13) [Ephedrine and ephedra in weight loss products and other preparations].[Article in Dutch] by van der Hooft CS1, Stricker BH.(PubMed)
(14) Ginseng, Asian (Panax ginseng) and Ginseng, North America(Popular Chinese Herbs)
(15) Influence of Panax ginseng on obesity and gut microbiota in obese middle-aged Korean women by Song MY1, Kim BS2, Kim H(PubMed)
(16) Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet by Song YB1, An YR, Kim SJ, Park HW, Jung JW, Kyung JS, Hwang SY, Kim YS.(PubMed)
(17) Popular #Herbs - #Ginger (Zingiber officinale)(Popular Chinese herbs)
(18) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity by Hasani-Ranjbar S1, Nayebi N, Larijani B, Abdollahi M.(PubMed)
(19) Eight weeks of supplementation with a multi-ingredient weight lossproduct enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women by Lopez HL1, Ziegenfuss TN, Hofheins JE, Habowski SM, Arent SM, Weir JP, Ferrando AA.(PubMed)
(20) Comparative evaluation of the efficacy of ginger and orlistat on obesity management, pancreatic lipase and liver peroxisomal catalase enzyme in male albino rats by Mahmoud RH1, Elnour WA.(PubMed)
(21) The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome by Oben J1, Kuate D, Agbor G, Momo C, Talla X.(PubMed)
(22) The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. by Oben JE1, Ngondi JL, Momo CN, Agbor GA, Sobgui CS.(PubMed)
(23) The effect of Cissus quadrangularis (CQR-300) and a Cissusformulation (CORE) on obesity and obesity-induced oxidative stress by Oben JE1, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA.(PubMed)
(24) An observational study and quantification of the actives in a supplement with Sambucus nigra and Asparagus officinalis used for weight reduction by Chrubasik C1, Maier T, Dawid C, Torda T, Schieber A, Hofmann T, Chrubasik S.(PubMed)
(25) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity by Hasani-Ranjbar S1, Nayebi N, Larijani B, Abdollahi M(PubMed)
(26) #Healthy #Foods - Vegetables - Asparagus (Asparagus officinalis)(health tips for better living and living health)
(27) An observational study and quantification of the actives in a supplement with Sambucus nigra and Asparagus officinalis used for weight reduction by Chrubasik C1, Maier T, Dawid C, Torda T, Schieber A, Hofmann T, Chrubasik S.(PubMed)
(28) Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects--a randomised double-blind placebo-controlled clinical trial by Opala T1, Rzymski P, Pischel I, Wilczak M, Wozniak J.(PubMed)
(29) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity by Hasani-Ranjbar S1, Nayebi N, Larijani B, Abdollahi M.(PubMed)
Tuesday, August 18, 2020
Herbal Cranberry, a Potential and Natural Prevention and Treatment of Esophageal Tumor
The esophagus formed part of the digestive system is a muscular tube that connects the throat (pharynx) with the stomach located behind the trachea and heart and in front of the spine.
Cancer is a group of chronic diseases associated with irregular cell growth that start in the cell on the surface of the inner lining tissue of the specific gland and organ before penetrating into deeper layers to form tumors through unlimited cell cycle division.
Over time, most cancers have become progressively worse and spread to other organs in the body via lymph or blood.
Esophageal cancer is not very uncommon in the US caused by malignant cells of the esophagus due to cell DNA alternation.
Primary esophageal cancer has been found to spread to the bottom of the esophagus, stomach, and chest.
According to the statistics, compared to the US, esophageal cancer is more often diagnosed in other parts of the world and the seventh most common cause of cancer death among men.
Believe it or not, every year, the disease causes the death of 16,000 individuals, including 13,000 men and 3,000 women,
Compared to other cancers the 5-year survival rate for people with esophageal cancer is only 19%.
The exact causes of esophageal cancer are unidentified. However, according to the epidemiological studies, aging, male gender, smoking, excessive alcohol drinking, genetic preposition, obesity, thermal injury to the esophagus are some prevalent factors that increase the risk of the disease.
Some researchers suggested that the increased incidences of esophageal cancer in the Western world over the past few decades may be correlated to the promotion of a high-fat diet.
Dr. Silvano Gallus wrote, "Over the last 30 years, the incidence of squamous-cell carcinoma has decreased in several areas of the world, but adenocarcinoma has risen by over fourfold in the US as well as in Australia and several areas of Europe; its incidence has particularly increased in men".
And, " diets high in saturated fat and cholesterol have been associated with an increased risk (of esophageal cancer)".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of gastrointestinal tumor, researchers examined the effect of a purified cranberry-derived proanthocyanidin extract (C-PAC) on esophageal adenocarcinoma (EAC) cell lines, including acid-sensitive JHAD1 and OE33 cells, and esophageal tumor xenografts in athymic NU/NU mice.
According to the tested assays, C-PAC shared a strong activity in inducing the expression of a protein associated with cell death programming mainly in JHAD1 and OE33 cells.
Autophagy that promotes cancer cell growth and anti-apoptosis of JHAD1 and OE33 cells were also inhibited by the injection of C-PAC.
In vitro, C-PAC induced cell death was attributed to deactivation of the phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways expression in the promotion of cancer cellular processes, including cell survival, growth, and differentiation.
Additionally, C-PAC not only inhibited the levels of anti-apoptotic proteins such as BCL-xL, Cytochrome C, PARP), pathways involved in the occurrence and progression of cancer, but also exhibited the expression of proteins that induces cell cycle arrest.
Similarly, in vivo, oral delivery of C-PAC significantly inhibited OE19 tumor xenograft growth as the aforementioned activities.
In other words, in vitro and vivo purified cranberry-derived proanthocyanidin extract (C-PAC) eradicate the esophageal adenocarcinoma (EAC) cells through several mechanisms involved in pro-apoptosis, anti-anti-apoptosis, and blocking cellular division.
Based on the finding, researchers after taking other factors into account wrote, " C-PAC is a potent inducer of EAC cell death and is efficacious in vivo at non-toxic behaviorally achievable concentrations, holding promise for preventive or therapeutic interventions in cohorts at increased risk for EAC, a rapidly rising and extremely deadly malignancy".
Taken altogether, cranberry extract may be considered a remedy for the prevention and treatment of esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary feeding of freeze-dried whole cranberry inhibits intestinal tumor development in Apcmin/+ mice by Jin D#1, Liu T#1, Dong W1, Zhang Y2, Wang S1, Xie R1, Wang B1, Cao H. (PubMed)
(2) Is There a Link Between Diet and Esophageal Cancer? by Silvano Gallus, and Carlo La Vecchia. (Medscape)
Cancer is a group of chronic diseases associated with irregular cell growth that start in the cell on the surface of the inner lining tissue of the specific gland and organ before penetrating into deeper layers to form tumors through unlimited cell cycle division.
Over time, most cancers have become progressively worse and spread to other organs in the body via lymph or blood.
Esophageal cancer is not very uncommon in the US caused by malignant cells of the esophagus due to cell DNA alternation.
Primary esophageal cancer has been found to spread to the bottom of the esophagus, stomach, and chest.
According to the statistics, compared to the US, esophageal cancer is more often diagnosed in other parts of the world and the seventh most common cause of cancer death among men.
Believe it or not, every year, the disease causes the death of 16,000 individuals, including 13,000 men and 3,000 women,
Compared to other cancers the 5-year survival rate for people with esophageal cancer is only 19%.
The exact causes of esophageal cancer are unidentified. However, according to the epidemiological studies, aging, male gender, smoking, excessive alcohol drinking, genetic preposition, obesity, thermal injury to the esophagus are some prevalent factors that increase the risk of the disease.
Some researchers suggested that the increased incidences of esophageal cancer in the Western world over the past few decades may be correlated to the promotion of a high-fat diet.
Dr. Silvano Gallus wrote, "Over the last 30 years, the incidence of squamous-cell carcinoma has decreased in several areas of the world, but adenocarcinoma has risen by over fourfold in the US as well as in Australia and several areas of Europe; its incidence has particularly increased in men".
And, " diets high in saturated fat and cholesterol have been associated with an increased risk (of esophageal cancer)".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of gastrointestinal tumor, researchers examined the effect of a purified cranberry-derived proanthocyanidin extract (C-PAC) on esophageal adenocarcinoma (EAC) cell lines, including acid-sensitive JHAD1 and OE33 cells, and esophageal tumor xenografts in athymic NU/NU mice.
According to the tested assays, C-PAC shared a strong activity in inducing the expression of a protein associated with cell death programming mainly in JHAD1 and OE33 cells.
Autophagy that promotes cancer cell growth and anti-apoptosis of JHAD1 and OE33 cells were also inhibited by the injection of C-PAC.
In vitro, C-PAC induced cell death was attributed to deactivation of the phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin (mTOR) signaling pathways expression in the promotion of cancer cellular processes, including cell survival, growth, and differentiation.
Additionally, C-PAC not only inhibited the levels of anti-apoptotic proteins such as BCL-xL, Cytochrome C, PARP), pathways involved in the occurrence and progression of cancer, but also exhibited the expression of proteins that induces cell cycle arrest.
Similarly, in vivo, oral delivery of C-PAC significantly inhibited OE19 tumor xenograft growth as the aforementioned activities.
In other words, in vitro and vivo purified cranberry-derived proanthocyanidin extract (C-PAC) eradicate the esophageal adenocarcinoma (EAC) cells through several mechanisms involved in pro-apoptosis, anti-anti-apoptosis, and blocking cellular division.
Based on the finding, researchers after taking other factors into account wrote, " C-PAC is a potent inducer of EAC cell death and is efficacious in vivo at non-toxic behaviorally achievable concentrations, holding promise for preventive or therapeutic interventions in cohorts at increased risk for EAC, a rapidly rising and extremely deadly malignancy".
Taken altogether, cranberry extract may be considered a remedy for the prevention and treatment of esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary feeding of freeze-dried whole cranberry inhibits intestinal tumor development in Apcmin/+ mice by Jin D#1, Liu T#1, Dong W1, Zhang Y2, Wang S1, Xie R1, Wang B1, Cao H. (PubMed)
(2) Is There a Link Between Diet and Esophageal Cancer? by Silvano Gallus, and Carlo La Vecchia. (Medscape)
Monday, August 17, 2020
Herbal Cinnamon and Diabetes
Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professions because of its anti-diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects. According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce the blood sugar significantly with little or no adverse effects.
The herb has been used in herbal and traditional medicine as anti-fungal and bacteria levels to improve the reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).
According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.
In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a significant reduction of blood triglyceride levels in the low-dose group, after 3 months of oral administration(2)
Some researchers suggested that cinnamon extract may improve fasting blood glucose levels and glucose tolerance without altering insulin secretion, through lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues(3).
Dr. Kim SH and Dr. Choung SY. told PubMed "The effect of cinnamon in significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR(in the regulation of metabolism (carbohydrate, lipid, protein))-medicated glucose and lipid metabolism"(4)
In support of the above, chromium(Cr) and polyphenols found in cinnamon (Cinnamomum cassia) indicated an improvement of glucose, insulin, cholesterol and HbA1c(Glucose lab test) in patients with type 2 diabetes following Cr supplementation, in a double-blind placebo-controlled study(7).
Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose but insisted that high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)
A randomized clinical trial in which 70 patients with type II diabetes assigned randomly two groups (35 in cinnamon and 35 in the placebo group for the testing of the effect of cinnamon on the glucose level in the blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).
Taken altogether, cinnamon in a low dose may be effective in controlling the levels of blood glucose in patients with diabetes without altering the insulin level. According to DR. Georgakopoulou EA., oral intake of Cinnamon may cause Stomatitis(7), and burning sensation in mouth with a large amount. Traditional Chinese medicine also insisted that Overdoses of cinnamon can be toxic and damage to the liver(1).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs http://kylejnorton.blogspot.ca/p/blog-page_24.html
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References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
The herb has been used in herbal and traditional medicine as anti-fungal and bacteria levels to improve the reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).
According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.
In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a significant reduction of blood triglyceride levels in the low-dose group, after 3 months of oral administration(2)
Some researchers suggested that cinnamon extract may improve fasting blood glucose levels and glucose tolerance without altering insulin secretion, through lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues(3).
Dr. Kim SH and Dr. Choung SY. told PubMed "The effect of cinnamon in significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR(in the regulation of metabolism (carbohydrate, lipid, protein))-medicated glucose and lipid metabolism"(4)
In support of the above, chromium(Cr) and polyphenols found in cinnamon (Cinnamomum cassia) indicated an improvement of glucose, insulin, cholesterol and HbA1c(Glucose lab test) in patients with type 2 diabetes following Cr supplementation, in a double-blind placebo-controlled study(7).
Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose but insisted that high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)
A randomized clinical trial in which 70 patients with type II diabetes assigned randomly two groups (35 in cinnamon and 35 in the placebo group for the testing of the effect of cinnamon on the glucose level in the blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).
Taken altogether, cinnamon in a low dose may be effective in controlling the levels of blood glucose in patients with diabetes without altering the insulin level. According to DR. Georgakopoulou EA., oral intake of Cinnamon may cause Stomatitis(7), and burning sensation in mouth with a large amount. Traditional Chinese medicine also insisted that Overdoses of cinnamon can be toxic and damage to the liver(1).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Researched articles - Points of view of Vitamins, Foods and Herbs http://kylejnorton.blogspot.ca/p/blog-page_24.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)
(7) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
Sunday, August 16, 2020
Chaste tree berry, a Functional Herb for Ameliorated Risk and Treatment of Gastric Cancer
The study conducted by a respectable institutions suggested that Chaste tree berry may have a potential effect in reduced risk and treatment of gastric/stomach cancer.
Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of gastric cancer.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the Tokyo University of Pharmacy and Life Science, ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) displayed a strong cytotoxic activity against human gastric cancer cells through induction of apoptosis.
The efficacy of anti gastric cancer of the extract is a result of antioxidant activity in reduced progression of oxidative stress which can be detected through
using 2',7'-dichlorofluorescin-diacetate.
Dr.Ohyama K, the lead author said, " Our results demonstrate that intracellular oxidative stress and mitochondrial membrane damage is responsible for Vitex-induced apoptosis, which may be mediated by a diminution of reduced type glutathione within the cell".
Furthermore, in the support of the above differentiation, another study conducted by the same institution, suggested that Vitex extracted expressed similar effect against human gastric signet ring carcinoma cell line, KATO-III, through separating or breaking of DNA in a time- and dose-dependent manner.
Additionally, the study also indicated, Vitex-induced apoptosis by elevated the intracellular oxidative stress and mitochondrial membrane damage of gastric cancer cell lines through the mediation of the presence of reduced type glutathione within the cell.
Other; in the investigate the cytotoxicity of the extract against serval human cancer cell line, including gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), showed that injection of the extract exhibited a significant effect in interference of the cell cycle division, reduced DNA abnormal expression through antioxidative reagent pyrrolidine dithiocarbamate or N-acetyl-L-cysteine (NAC).
Finally, according to Dr. Ohyama K, the lead author, the cytotoxic activity of Vitex extract may be attributed to the effect on cell growth in the expression of apoptotic cell death by increased intracellular oxidation.
Taking together, chaste tree berry exerted anti-cancer effect through various phytochemicals may be used as a functional food for ameliorated risk and treatment of gastric cancer, but intake of the large amount should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(3) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
Gastric cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of gastric cancer.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the Tokyo University of Pharmacy and Life Science, ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) displayed a strong cytotoxic activity against human gastric cancer cells through induction of apoptosis.
The efficacy of anti gastric cancer of the extract is a result of antioxidant activity in reduced progression of oxidative stress which can be detected through
using 2',7'-dichlorofluorescin-diacetate.
Dr.Ohyama K, the lead author said, " Our results demonstrate that intracellular oxidative stress and mitochondrial membrane damage is responsible for Vitex-induced apoptosis, which may be mediated by a diminution of reduced type glutathione within the cell".
Furthermore, in the support of the above differentiation, another study conducted by the same institution, suggested that Vitex extracted expressed similar effect against human gastric signet ring carcinoma cell line, KATO-III, through separating or breaking of DNA in a time- and dose-dependent manner.
Additionally, the study also indicated, Vitex-induced apoptosis by elevated the intracellular oxidative stress and mitochondrial membrane damage of gastric cancer cell lines through the mediation of the presence of reduced type glutathione within the cell.
Other; in the investigate the cytotoxicity of the extract against serval human cancer cell line, including gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), showed that injection of the extract exhibited a significant effect in interference of the cell cycle division, reduced DNA abnormal expression through antioxidative reagent pyrrolidine dithiocarbamate or N-acetyl-L-cysteine (NAC).
Finally, according to Dr. Ohyama K, the lead author, the cytotoxic activity of Vitex extract may be attributed to the effect on cell growth in the expression of apoptotic cell death by increased intracellular oxidation.
Taking together, chaste tree berry exerted anti-cancer effect through various phytochemicals may be used as a functional food for ameliorated risk and treatment of gastric cancer, but intake of the large amount should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(3) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
Saturday, August 15, 2020
Fennel,The Natural Remedy Which Protects the Brain Neurons Against The Onset of Cognitive Impairment, Scientists Suggest
Fennel may process a sustainable and therapeutic effect in enhancing cognitive functions, some scientists suggested.
Cognitive function is a mental process of the brain, with an aim to acquire knowledge by accumulating information through reasoning, memory, attention, and language, regardless of circumstances.
On the other hand, cognitive impairment, depending on the severity is a condition in which the infected person has trouble remembering, learning new things, concentrating, or making decisions that affect the quality of their everyday life.
In the elderly, most cases of cognitive impairment are associated with neurodegenerative diseases and longterm use of medication, including Alzheimer's;s disease.
However, malnutrition, hormone imbalance such as thyroid hormone, mental illness, and substance abuse, particularly, in brain damage or injury are some of the major and prevalent risk factors that can cause the early onset of cognitive impairment.
Some researchers suggested that people who have metabolic syndrome (abnormally high blood pressure, and high blood sugar, obesity and abnormal cholesterol or triglyceride level), mental illness, and previously disturbed the state of mind due to fever, intoxication is also at a higher risk of the condition develops.
Dr. Fernando Gómez-Pinilla, in the study of the effects of nutrients on brain function, wrote. "diets that are high in saturated fat are becoming notorious for reducing molecular substrates that support cognitive processing and increasing the risk of neurological dysfunction in both humans and animals"
And, Dr. Alan J. Gow, the lead scientist, in the study of the effects of lifestyle in cognitive impairment, said, " Lifestyle factors, particularly those which are malleable across the life course, maybe highly informative for the development of interventions to reduce or delay age-related cognitive decline".
These explanations strongly agreed that following healthy diet plenty of fruits and vegetables and less in saturated and trans fat, processed meat, refined products,...... salt and sugar, and lifestyle with moderate exercise may have a significant effect in protecting the brain neurons against the onset of cognitive impairment.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
.
Anethole, the main fragrance and bioactive compound of fennel, in the study of 20 other plant species was found to process nootropic activity in protecting the degeneration of the neurons, including diseases associated with a decline in cognitive abilities such as Alzheimer's disease through its anti-inflammatory and neuroprotective expression.
In the inflammatory expression, the application of anethole exerted a significant effect in mediated NF-kB in the systematically inflammatory response induced by transcription of proinflammatory genes and TNF-α signaling in the production inflammatory factors in the acute phase of infection.
The initiation of the pro-inflammatory cytokine in the case of acute infection is a natural defense of the immune response to protect the injured tissue against the invasion of bacteria and viruses. However, overexpression of inflammatory factors may also catalyze tissue damage and cause neuron cell death.
In an oxidative perspective, the application of anethole in the tested model also demonstrated a strong effect in inhibiting reactive oxygen species ROS which causes the cytotoxicity to neuron through its antioxidant and stimulated the production of the host antioxidant defense.
Injection of anethole also rebalanced the ratio of levels of free radicals and antioxidants, thus reducing the risk in the initiated production of pro-inflammatory cytokines in the precipitation of the death of the brain cell that controls memory or other cognitive functions.
Furthermore, in the evaluated fennel effect in Alzheimer's disease, a neurodegenerative disorder associated with a decline in cognitive abilities, researchers found that fennel intake exerts a strong neuroprotective effect in protecting against the progressive degeneration.
The methanol extract of the whole plant of F. vulgare administered for eight successive days ameliorated the deficit of memory caused by brain damage, disease, or psychological trauma induced by scopolamine and aging-induced memory deficits in mice.
In acetylcholinesterase AChE induced neurotoxicity in mice, the application of extract also increased step-down latency and reserved the neuron damage caused by acetylcholinesterase AChE toxicity.
Dr. Preksha Dwivedi, the lead authors, after taking into account other co and confounders said, "Foeniculum vulgare Linn. The extract used as a nootropic and anticholinesterase agent in mice. F. vulgare extract increased step-down latency and acetylcholinesterase inhibition in mice significantly. F. vulgare is employed in the treatment of cognitive disorders such as dementia and Alzheimer's disease".
Taken together, fennel, fennel extracts or its bioactive anethole may be considered a functional food for enhancing the memory or other cognitive functions through its neuroprotective and nootropic activity. However, intake of fennel extracts should be taken with extreme care in the prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn by Joshi H1, Parle M.(PubMed)
(2) A TRADITIONAL APPROACH TO HERBAL NOOTROPIC AGENTS: AN OVERVIEW Preksha Dwivedi, Richa Singh, Mohd.Tabish Malik and Talha Jawaid(International Journal of Pharmaceutical Science and Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(4) Anethole and Its Role in Chronic Diseases by Aprotosoaie AC1, Costache II2, Miron A3.(PubMed)
(5) Brain foods: the effects of nutrients on brain function by Fernando Gómez-Pinilla. (PMC)
(6) Lifestyle Factors and Cognitive Ageing: Variation across Ability and Lifestyle Domains by Alan J. Gow, Allison A. M. Bielak, and Denis Gerstorf. (PMC)
Cognitive function is a mental process of the brain, with an aim to acquire knowledge by accumulating information through reasoning, memory, attention, and language, regardless of circumstances.
On the other hand, cognitive impairment, depending on the severity is a condition in which the infected person has trouble remembering, learning new things, concentrating, or making decisions that affect the quality of their everyday life.
In the elderly, most cases of cognitive impairment are associated with neurodegenerative diseases and longterm use of medication, including Alzheimer's;s disease.
However, malnutrition, hormone imbalance such as thyroid hormone, mental illness, and substance abuse, particularly, in brain damage or injury are some of the major and prevalent risk factors that can cause the early onset of cognitive impairment.
Some researchers suggested that people who have metabolic syndrome (abnormally high blood pressure, and high blood sugar, obesity and abnormal cholesterol or triglyceride level), mental illness, and previously disturbed the state of mind due to fever, intoxication is also at a higher risk of the condition develops.
Dr. Fernando Gómez-Pinilla, in the study of the effects of nutrients on brain function, wrote. "diets that are high in saturated fat are becoming notorious for reducing molecular substrates that support cognitive processing and increasing the risk of neurological dysfunction in both humans and animals"
And, Dr. Alan J. Gow, the lead scientist, in the study of the effects of lifestyle in cognitive impairment, said, " Lifestyle factors, particularly those which are malleable across the life course, maybe highly informative for the development of interventions to reduce or delay age-related cognitive decline".
These explanations strongly agreed that following healthy diet plenty of fruits and vegetables and less in saturated and trans fat, processed meat, refined products,...... salt and sugar, and lifestyle with moderate exercise may have a significant effect in protecting the brain neurons against the onset of cognitive impairment.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
.
Anethole, the main fragrance and bioactive compound of fennel, in the study of 20 other plant species was found to process nootropic activity in protecting the degeneration of the neurons, including diseases associated with a decline in cognitive abilities such as Alzheimer's disease through its anti-inflammatory and neuroprotective expression.
In the inflammatory expression, the application of anethole exerted a significant effect in mediated NF-kB in the systematically inflammatory response induced by transcription of proinflammatory genes and TNF-α signaling in the production inflammatory factors in the acute phase of infection.
The initiation of the pro-inflammatory cytokine in the case of acute infection is a natural defense of the immune response to protect the injured tissue against the invasion of bacteria and viruses. However, overexpression of inflammatory factors may also catalyze tissue damage and cause neuron cell death.
In an oxidative perspective, the application of anethole in the tested model also demonstrated a strong effect in inhibiting reactive oxygen species ROS which causes the cytotoxicity to neuron through its antioxidant and stimulated the production of the host antioxidant defense.
Injection of anethole also rebalanced the ratio of levels of free radicals and antioxidants, thus reducing the risk in the initiated production of pro-inflammatory cytokines in the precipitation of the death of the brain cell that controls memory or other cognitive functions.
Furthermore, in the evaluated fennel effect in Alzheimer's disease, a neurodegenerative disorder associated with a decline in cognitive abilities, researchers found that fennel intake exerts a strong neuroprotective effect in protecting against the progressive degeneration.
The methanol extract of the whole plant of F. vulgare administered for eight successive days ameliorated the deficit of memory caused by brain damage, disease, or psychological trauma induced by scopolamine and aging-induced memory deficits in mice.
In acetylcholinesterase AChE induced neurotoxicity in mice, the application of extract also increased step-down latency and reserved the neuron damage caused by acetylcholinesterase AChE toxicity.
Dr. Preksha Dwivedi, the lead authors, after taking into account other co and confounders said, "Foeniculum vulgare Linn. The extract used as a nootropic and anticholinesterase agent in mice. F. vulgare extract increased step-down latency and acetylcholinesterase inhibition in mice significantly. F. vulgare is employed in the treatment of cognitive disorders such as dementia and Alzheimer's disease".
Taken together, fennel, fennel extracts or its bioactive anethole may be considered a functional food for enhancing the memory or other cognitive functions through its neuroprotective and nootropic activity. However, intake of fennel extracts should be taken with extreme care in the prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cholinergic basis of memory-strengthening effect of Foeniculum vulgare Linn by Joshi H1, Parle M.(PubMed)
(2) A TRADITIONAL APPROACH TO HERBAL NOOTROPIC AGENTS: AN OVERVIEW Preksha Dwivedi, Richa Singh, Mohd.Tabish Malik and Talha Jawaid(International Journal of Pharmaceutical Science and Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(4) Anethole and Its Role in Chronic Diseases by Aprotosoaie AC1, Costache II2, Miron A3.(PubMed)
(5) Brain foods: the effects of nutrients on brain function by Fernando Gómez-Pinilla. (PMC)
(6) Lifestyle Factors and Cognitive Ageing: Variation across Ability and Lifestyle Domains by Alan J. Gow, Allison A. M. Bielak, and Denis Gerstorf. (PMC)
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