Herbal Angelica Induces Apoptosis of Human Neuroblastoma Cells

The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.

The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role in processing and transmitting the information.
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.

Cancer most commonly affects children age 5 or younger compared to less often in older children.

According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.

And 90% of children affected by neuroblastoma are younger than 5.

Sadly, the the-5-year survival rate of cancer is less than 50%.



Most common symptoms are totally depending on the area that has been effected
* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched and changes in bowel habits, such as diarrhea or constipation.

* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain and changes to the eyes, including drooping eyelids and unequal pupil size

Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.


On finding a natural ingredient for the prevention and treatment of brain cancer, scientists examined the effects of Angelica polymorpha Maxim root extract (APRE) cytotoxicity on neuroblastoma cells (NB).

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the final results of the experiment,
* APRE reduced cell viability in NB to a greater extent than in fibroblast cells.
* APRE could inhibit proteins and down-regulated pathways associated with cancer cell proliferation and survival.

* Furthermore, APRE promoted pro-apoptotic protein and inhibited the expression of proteins associated with anti-apoptosis.
* Moreover, APRE depolarized the mitochondria membrane potential and activation of caspase-3 associated with the cell death in the SH-SY5Y cells.

Additional differentiation, researchers said, "APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved".


Taken altogether, herbal angelica may be considered a remedy for the treatment of neuroblastoma, pending to the confirmation of the larger sample size and multicenter human study.

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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway by Rahman MA1, Bishayee K1, Huh SO. (PubMed)

Chaste Tree Berry, The Best Hepatoprotective Whole Herb Medicine

Chaste tree beery is found to associate with reduced risk of liver damage and diseases through various mechanisms, the recent study suggested

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

In acetaminophen-induced hepatotoxicity in mice study, oral administration of chaste tree berry increased significantly in the expression of levels of antioxidant in inhibition of free radicals domino' effect and levels of ferric ion in induced hepatotoxicity caused by acetaminophen.


According to the Al-Hikmah University, Hepatoprotective effects of chaste tree berry may also mediate the alternative effects of acetaminophen in serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin, and total bilirubin levels which can also contribute to hepatoxicity.



Dr. Ajiboye TO said, " Vitex doniana fruits possess antioxidant properties and halted acetaminophen-mediated oxidative rout on cellular proteins, lipids and DNA, made possible by β-sitosterol, platycodin D, apigenin, saikosaponin, chrysin and ellagitanin, (the antioxidants) in the extract".

Furthermore, ethanol extract Vitex glabrata (EEVG) on carbon tetrachloride-induced liver damage in rats, .displayed also antioxidant activity in inhibited superoxide dismutase, GSH, lipid peroxidation (LPO), catalase, and peroxidase levels in liver homogenate.

Pre-treatment of the extract illustrated a strong inhibited effect against levels of LPO in CCl(4)-intoxicated livers and reduced the elevated serum levels of chemical compounds which can cause liver damage

In fact, the extract displays an enormous hepaprotective effect similar to those of silymarin through enhancing antioxidant mechanisms of its components, predominantly artemetin.

According to the The Vinayaka Mission’s College of Pharmacy study, in the CCl4 induced hepatic injury in albino rats, vitex extract not only is comparable to the standard drug, silymarin (100 mg/kg, p.o.), but also altered serum biomarker enzyme levels which were damage through injection of CCI4, to near normal in treated rats.

Taking together, there is no doubt that Chaste tree berry may process a protective effect in reduced risk of harmful chemicals and drugs induced liver damage, but the injection of the large amount should be taken with care.


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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen-induced hepatotoxicity by Ajiboye TO1.(PubMed)
(2) Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats by Sridevi VK1, Chouhan HS, Singh NK, Singh SK.(PubMed)
(3) Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats by Anandan R1, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS.(PubMed)

Herbal Bilberry Improves Your Lipoprotein Parameters in Human Trials

The lipoprotein profiles or lipoprotein parameters are a general term comprised the traditional lipoprotein profile include total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride.

Total cholesterol is the total amount of cholesterol in your blood, including the low-density lipoprotein (LDL, or “bad”) cholesterol and high-density lipoprotein (HDL, or “good”) cholesterol.


The healthy ratio of blood cholesterol is less than 4 of the low-density lipoprotein to 1 of high-density lipoprotein.


Where low-density lipoprotein is produced by the liver or from food sources needed for the cells to build strong membranes, produce steroid hormones, vitamin D, and bile to aid the digestive system in absorbing nutrients and fluids.

And high-density lipoprotein produced by the liver or from the external sources needed to return the low-density lipoprotein back to the liver.

Triglycerides, an important measure of heart health is the fat in the blood caused by the over-consumption of foods containing fat, carbohydrates, and simple sugars.

Factors that affect your lipoprotein profiles can be unpreventable including age, gender, race, and genetic preposition and preventable such as diet, weight, physical activity, and smoking.


Some researchers suggested that people who are obese are at a substantially higher risk of poor lipoprotein profiles.


Dr. Pandolfi C, the lead scientist wrote, "Lipid pattern has resulted in overlapping both in the two studied populations and in the two subgroups of pre- and postmenopausal women, while greater concentrations of Lp(a), (p < 0.001) and t-PA (p < 0.05) have been found in obese populations vs controls".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In the urgency on finding natural sources of the plant-based compound for the prevention of cardiovascular disease (CVD), researchers investigated regular consumption of bilberries in CVD risk reduction.

Women (n=25) and men (n=11) selected to the study received 150 g of frozen stored bilberries 3 times a week for 6 weeks. All parameters associated with the risk CVD were measured by standard assays.

In both sexes, the consumption of bilberries led to a decrease in the parameters of lipoprotein profiles, including total cholesterol, LDL-C, TG, and a positive increase in HDL-C.


However, in men, additionally, favorable changes were observed in total cholesterol (P=.004), reduced oxidative stress, and HDL-C, but an increase in LDL-C compared to women group.


In other words, the regular intake of bilberries can be important to reduce CVD risk, by promoting a decrease of LDL-C/TG and an increase of HDL-C.

Furthermore, in order to reveal more information about bilberry against CVD risk, researchers compared consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD, 1:1), or frozen bilberries on metabolic profiles.


In a total of 80 women selected to complete this randomized crossover study for 30 d, all interventions induced a significant effect on the overall metabolic profiles, particularly in lipid parameters observed both in participants who had a metabolic profile that reflected higher cardiometabolic risk at baseline (group B) and in participants who had a lower-risk profile (group A).

However, the bilberries treatment group caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.

The finding clearly suggested bilberries modulated the parameters of lipids and lipoproteins depending on the risk of CVD.

Dr. Larmo PS, after taking into account co and confounders wrote, "Berry intake has overall metabolic effects, which depend on the cardiometabolic risk profile at baseline (including bilberry)".

Taken altogether, bilberry may be considered a functional remedy for the promotion of lipid-protein profiles in reducing the risk of CVD, pending to the validation of a larger sample size and multicenter human study.


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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovasculardisease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(3) [Lipoprotein(a), parameters of lipid metabolism and hemostasis in obese patients].[Article in Italian] by Pandolfi C1, Pellegrini L, Dedè A, Lo Vecchio M, Mercantini F. (PubMed)

Herbal Dandelion(Taraxacum officinale) Promotes Gastric Emptying and Smooth Muscle Motility

The digestive system including the gastrointestinal (GI) tract, the liver, pancreas, and gallbladder processes the function to digest foods and transfer the nutrients and fluids to the body's needs.

There is no single cause of the gastrointestinal disorder. Researchers suggested that the cause of the disorder can be attributed directly to the digestive system, or other systemic problems that facilitate the onset of disease.

However, according to the epidemiological studies, bacterial infection, viral infection, inflammation, muscle dysfunction, gallstones, stress, and intake of certain anti-inflammatory drugs are associated with the onset of the acute and chronic digestive disorders.

Dietary factors also play an important in the reduction and promotion of digestive dysfunction. People who are overeating, eating too much fatty food, not consuming enough fiber, and consuming too much alcohol and smoking are at a higher risk of digestive diseases, including ulcers and gastric acid reflux.

Gastric emptying is a test that measures the time that takes for food to empty from the stomach and enter the small intestine. The test is used to find out why your child is vomiting, having stomach pain or not gaining weight.

Gastrointestinal motility is the contraction of the smooth muscles of the gastrointestinal tract.

The gastroprotective effect is a process involved enhancing the function of the digestive system against the harmful organisms in induced chronic digestive disorder.

People with digestive problems may experience certain stomach discomfort, including bloating. constipation. diarrhea. heartburn, nausea and vomiting,......., and belly pain.

Untreated digestive problems over the long term can induce serious ailments of chronic illnesses, as the digestive system no longer performs its functions in provided nutrients and fluids to the needs of the body's cells and tissue.

The results of malnutriments over a long period of time can lead to weakened immune defense and reduced levels of antioxidants produced by tissues of the body in fighting against pathogens,

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the improvement of digestive functioning, scientists examined the effects of Taraxacum officinale (TO) is a traditional herbal medicine on gastric emptying (GE) and smooth muscle motility.

According to the administration of ethyl acetate fraction (EA), n-butanol fraction (BF), and aqueous fraction (AF) prepared in succession from 70% ethanol extract (EE) of TO in phenol red meal adopt mice,
* The percentage of GE was 48.8 ± 6.1% (vehicle control), 75.3 ± 6.5% (cisapride positive control), 68.0±6.7% (EE), 53.3±6.0% (EA), 54.1±6.3% (AF), and 86.0±6.5% (BF).

* Furthermore, BF was most effective in accelerating GE, compared to others.

* Moreover, the stimulatory effect of BF on GE was also supported by the observation that BF increased spontaneous contraction of the gastric fundus and antrum and decreased the spontaneous motility of pyloric sphincter in vitro.

Based on the findings, researchers said, "BF seems to be a promising prokinetic agent. BF-induced increase in the contraction of fundus and antrum contributes to an increase in the intra-gastric pressure. BF-induced decrease in the motility of pyloric sphincter contributes to a decrease in the resistance of food from the stomach to the small intestine"

And "The acceleration of GE by BF is likely to be exerted through cholinergic stimulation".

Taken altogether, Dandelion that processed the aforementioned chemical compounds may be considered a gastric emptying and smooth muscle motility remedy, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effect of Taraxacum officinale on gastric emptying and smooth muscle motility in Rodents by Jin YR1, Jin J, Piao XX, Jin NG. (PubMed)

Bromelain Normalizes the Enzymes In Blood Clots

Fibrinolysis is the condition associated with the enzymatic breakdown of the fibrin in blood clots.

Where fibrin plays an essential role in hemostasis as both the primary product of the coagulation cascade of fibrinolysis.

In other words, fibrinolysis is a process that prevents blood clots from growing to induce certain health problems such as cardiovascular disease.

Platelet aggregation is a condition characterized by platelets clumping together in the blood. The process also is necessary for the cover of vascular injury. However, overexpression of platelet counts in the blood is problematic to human health.

In other words, the production of blood platelets is to protect tissue injury against infection.
Furthermore, platelet disorders can lead to abnormal bleeding. Most common types of the genetic proposition of platelet disorders including

* Disorder of platelet adhesion, also known as Bernard-Soulier Syndrome is a condition in which the platelets fail to adhere together, leading to frequent bruises, nose bleeds and bleeding in the mouth and gums.

* Disorder of platelet aggregation also known as Glanzmann Thrombasthenia is a condition that the platelets not only fail to cover at the site of an injury but also prolong the bleeding.

* Disorder of platelet secretion is a condition that causes the slows down normal platelet adhesion, aggregation, and repair of the blood vessel.

* Disorder of platelets procoagulant activity, also know as Scott Syndrome is a condition in which the platelets fail to promote activation of the blood clotting proteins.

Conventionally, certain medications with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.

Dr. Wolberg AS in the examination of fibrinolysis in the changes on the local concentrations of pro- and anti-coagulants and cellular activities may affect the clot-forming wrote, "patterns of abnormal thrombin generation produce clots with altered fibrin structure and that these changes are associated with an increased risk of bleeding or thrombosis".

These results strongly outline the importance of fibrin in the formation of a blood clot in the presence of thrombin that converts fibrinogen to fibrin.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the treatment of fibrinolysis, researchers examined the influence of bromelain on platelet count, platelet aggregation, and platelet activity in vitro.

The study included blood samples taken from the antecubital vein of 10 healthy male non-smokers.

According to the tested observation, platelet count decreased after incubation with 2.5 and 5 mg bromelain/ml.


The levels of ADP and TRAP-6 associated with platelet aggregation were inhibited after incubation with 2.5 mg or 5 mg compared to control.

Interestingly, according to the flow cytometry, the percentage of the total number of platelets or unstimulated CD62P positive platelets.


In other words, under normal conditions, bromelain does not have any effect on unstimulated CD62P positive platelets even with higher incubation with 5 mg bromelain/ml compared to control.


However, after TRAP-6 stimulation with platelet aggregation, the incubation with 5 mg bromelain/ml led to a remarkable decrease, compared to the untreated control.

The changes of CD62P (TRAP-stimulated) and the results of platelet aggregation after incubation with bromelain in vitro may demonstrate the potential of bromelain as a substance for platelet inhibition.

Based on the findings, researchers said, "The changes of CD62P (TRAP-stimulated) and the results of platelet aggregation after incubation with bromelain in vitro may demonstrate the potential of bromelain as a substance for platelet inhibition".

These results suggested that bromelain has a strong effect on the prevention and treatment of cardiovascular disease associated with platelet aggregation.


Taken altogether, bromelain may be considered a remedy for the prevention and treatment of fibrinolysis,, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) Thrombin generation and fibrin clot structure by Wolberg AS. (PubMed)

Cranberry in the Promotion of Digestive Health

The digestive system included the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body normal function by providing nutrients and fluids to the body and remove waste through the secretary system.


Digestion is a process of the digestive system by breaking down food for nutrients through mechanical and enzymatic action.

Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.

Under normal conditions, gut microbiota plays a critical role in overall health, including improving the absorption of the dietary nutrients of the digestive system, protecting the body against xenobiotics and drug toxicity through facilitating the excretion.

Futhermore, the gut microbiota also involved in the maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.

In immunomodulation, gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

However, imbalanced of the ratio of gut microbiota may have a negative on human health and diseases.

Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".

And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of digestive health, researchers examined the effect of Vaccinium berry fruit in modulating gut microbiota function.

According to the tested differentiation, cranberry anthocyanidins only interfered with the colonization of the gut by Escherichia coli in vitro but also attenuated gut barrier dysfunction caused by dietary insults in vivo.

The efficacy of cranberry anthocyanidins in the promotion of gut microbiota in the flavor of the good bacterias was attributed by the synergic activity between these proanthocyanidins, other cranberry components such as isoprenoids and xyloglucans.

Furthermore, cranberry constituents and their bioactive catabolites also have a strong effect on bacterial adhesion, coaggregation, and biofilm formation that may contribute clinical benefits on gastrointestinal and urinary tract infections,

Additionally, cranberry constituents and their bioactive catabolites also processed strong anti-inflammatory actions by mediating the gut microbiome.

Taken altogether, cranberry may be considered a remedy for the improvement of the digestive health, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MeseaNeto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)
(2) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang, Sha Li and Ren-You Gan. (Research Gate)

Chaste Tree Berry Expressed Various Mechanisms in Inhibition of Leukemia

Oral Administrated ripe fruit of Vitex agnus-castus (Vitex) may reduce the risk of various types of solid tumor cells, particularly leukemia.

Leukemia is a condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

According to the Tokyo University of Pharmacy and Life Sciences, casticin,, the major chemical compound found in extract from the ripe fruit of Vitex agnus-castus (Vitex) exhibited strong cytotoxic activities against on leukemia cell lines, HL-60 and U-937 in dose depending manner.


Additionally, the study also expressed an interest result as the levels of cytotoxicity of Vitex/casticin were largely attributed to the degree of differentiation of leukemia cells depending to cancer cell line maturity. in compared to the HL-60 cell line with less mature U-937 cell line.


Dr. Kikuchi H, the lead author said, "casticin accounted for approximate 1% weight of Vitex. Dose-dependent cytotoxicity of Vitex and casticin was observed in both cell lines, and HL-60 cells were more sensitive to the cytotoxicity of Vitex/casticin compared to U-937 cells".

In further study, casticin, also displayed a sigmificant anti leukemia activity cells through expression molecular mechanism. apoptosis and cell cycle arrest observed through different assays.


The application of casticin yielded a result of cancer cell death at 75.3% at 12 in G2 phase in tumor cells cycle division, increased and subsequently declined to 27% at 48 h which was an indication of leukemic cell death via apoptosis and mitotic catastrophe.


Other study in support to the above differentiation, suggested that the extract from the ripe fruit of Vitex angus-castus (Vitex), inhibited the leukemia cell lines probably due to other mechanism such as significant decrease levels of intracellular reactive oxygen species (ROS) and level of gp91(phox), an important component of NADPH oxidase, in production of oxidation, and mediated cytotoxicity in HL-60 cells by regulating ROS generation...


Taking together, Chaste tree berry has a significant implication in reduced risk and treatment of leukemia through number of mechanisms, but intake of large amount should be taken with care to prevent toxicity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines by Kikuchi H1, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H.(PubMed)
(2) Casticin induces leukemic cell death through apoptosis and mitotic catastrophe by Shen JK1, Du HP, Yang M, Wang YG, Jin J.(PubMed)
(3) Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract by Kikuchi H1, Yuan B1, Yuhara E1, Imai M1, Furutani R1, Fukushima S1, Hazama S1, Hirobe C2, Ohyama K1, Takagi N3, Toyoda H1.(PubMed)