Lupus nephritis is a condition of kidneys an inflammation caused by systemic lupus erythematosus (SLE), an autoimmune disease.
It is a type of glomerulonephritis in which the glomeruli become inflamed.
Kidneys are a pair of bean-shaped organs, located just below the rib cage, one on each side of your spine with a function to filter out blood toxins through urinary secretion.
Believe it or not, every day, the blood passes the kidneys many times. Some people with only 10% of kidney function showed no symptoms of toxin accumulation.
However, if the kidney fails to cleanse the blood due to kidney failure, patients may experience symptoms of decreased urine output, fluid retention in your legs, ankles, or feet.
Depending on the severity of toxins accumulation, some patients may also experience symptoms of shortness of breath and confusion.
Lupus nephritis reduced kidney function may cause symptoms of sudden and unexplained swelling feet, ankles, legs, fingers, arms or the eyes, foamy appearance in urine, and frequent urination.
In severe cases, patients may also have symptoms of blood in urine and elevated blood pressure.
Out of many risk factors associated with the risk of lupus nephritis, some researchers suggested genetic preposition may be a strong impact that leads to the early onset of the disease.
Dr. the lead scientist wrote, " Although many SLE susceptibility genes have been identified, the genetic basis of LN is not as well understood".
And, "some of the established general SLE susceptibility genes are associated with LN, recent discoveries highlight a number of genes with renal functions that are specifically associated with LN. Some of these genes associated with LN help to explain the disparity in the prevalence of nephritis between individuals with SLE, and also partially explain differences in LN between ancestral backgrounds".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential ingredient for the treatment of lupus nephritis, researchers investigated the effects of curcumin on lupus nephritis (LN) induced animal model.
LN established New Zealand Black/White (NZB/W) F1 female mice, at 18 weeks of age were fed a standard diet or a diet containing 1 % curcumin until the end of the study.
During the study, infection of curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a which were elevated in LN mice.
Where proteinuria is the ratio of a protein/creatinine greater than 45 mg/mmol and high levels of IgG1, IgG2a is an indication of immune defect.
Additonally, curcumin also protected the kidneys against inflammation by reducing the anti-dsDNA IgG antibodies which were also elevated in NZB/W F1 female mice.
Where elevated levels of anti-dsDNA IgG antibodies are associated with ongoing inflammation and damage to the kidneys.
Furthermore, IgG immune complex deposition in the glomeruli was also reduced in curcumin-treated mice.
In other words, curcumin suppressed the pro-inflammatory expression in the kidney glomeruli.
Moreover, according to the kidney tested assays, kidney inflammation was also decreased after curcumin treatment.
More importantly, researchers discovered that treatment with anti-CD25 antibody injection that causes Treg depletion also affects the therapeutic effects of curcumin.
Where the anti-CD25 antibody is a conventional medicine used for enhancing the immune response.
More precisely, curcumin cannot be used in combination with anti-CD25 antibody daclizumab that
targets the T cells for the treatment of lupus nephritis.
Based on the findings, researchers said, "Curcumin exerted a protective effect against LN in NZB/W F1 mice. We speculate that the protective effects of curcumin in LN may involve, at least in part, its interaction with Treg cells".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of lupus nephritis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice by Lee H1, Kim H, Lee G, Chung HS, Bae H. (PubMed)
(2) Genetics of human lupus nephritis by Iwamoto T1, Niewold TB. (PubMed)
Tuesday, October 20, 2020
Saturday, October 17, 2020
The Antidepression Natural Whole Food, Biomedical Literature Suggested
Scientists may have found a dietary vegetable that processes a strong and profound impact in ameliorated psychological depression, a recent study suggested.
Depression is a common psychological disease that affects your normal feeling, thinking and reacting to events that occur daily in your life.
People with depression may feel ashamed or afraid to ask for help. others suffer in silence.
According to the statistic of the World Health Organization, 300 million people around the world have depression. The numbers of Americans suffer from depression are increasing at an alarming rate. As of today, 16.2 million adults in the United States or 6.7% of all adults have depression in the country.
Women are more susceptible to develop depression than men and fewer than half of those affected by depression in the world is seeking professional treatment.
The disease is the leading cause of disability worldwide, and a major contributor to the overall global burden of diseases.
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million
Contrary to some misconceptions, depression can be treated and avoidable.
What cause depression? is debatable, however, genetic predisposition, personality, stress and brain chemistry are found to associate to the onset of the disease.
Chronic medical conditions also can trigger the development of depression. According to the study by the Shanghai University of Sport in the review of 60 articles with a total of 4311 patients, chronic diseases are highly correlated to the expression of depression and reduced quality of life(5).
The study also suggested that increasing SF-36 physical function subscale in such patients in short and long term may have a profound and positive effect in ameliorated depression and improved quality of life.
The use of antidepressants by conventional medicine may be effective. However, they can induce side effects of an upset stomach, insomnia, sexual problems, anxiety, dizziness,....., and fatigue.
In severe cases, the intake of depressants may cause serotonin syndrome, seizures, irregular heartbeat, and unconsciousness and some people in the group under the age of 25 may experience suicidal thoughts, according to the BBC report By Lesley Ashmall(6).
Asparagus is a flowering plant, belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and Western Asia.
The vegetable has been used from early times as a food and medicine, because of its delicate flavor and diuretic properties.
In an oral administration of methanolic extract of roots of AR (MAR) of the doses of 100, 200, and 400 mg/kg daily for 7 days and then subjected to forced swim test(FST) in mice, researchers found that application of the extract decreases immobility in FST and increases avoidance response in learned helplessness test (LH), an indication of antidepressant activity.
Dr. Singh GK, the lead author said, " MAR had an insignificant effect on l-DOPA-induced aggressive behavior indicating the absence of activity on the dopaminergic system" and "MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems and augmentation of antioxidant defenses".
Furthermore, the injection of extracts of Asparagus cochinchinensis (AC) also expressed antidepressive effects, through inhibited oxidative stress that cause neuron cell damage and improve cell signal response and signal transmitting.
Total saponin isolated from AC significantly is found to inhibit the free radical of H2O2 in the induction of cell death in cultured cortical neurons.
Additional analysis suggested that AC antidepressant-like and neuroprotective (reducing infarct size) effects are associated with the activation of Shp-2 pathways which are associated with the inhibition of depression in an animal model.
Some researchers suggested that antidepressant activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitters system, and cognitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system...
Moreover, the study also showed that AR may be used as food and have potential drug-drug, drug-food, and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending a message between neurons, induced protective activities against the development of depression.
These results suggested that asparagus ameliorated depression with its neuroprotective effect by inhibited free radical that cause neuro cells damage and improved cell signal response.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-depression possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)
(5) Effect of traditional Chinese exercise on the quality of life and depression for chronic diseases: a meta-analysis of randomised trials by Wang X1,2, Pi Y3, Chen B1, Chen P1, Liu Y4, Wang R4, Li X1, Zhu Y5, Yang Y6, Niu Z(PubMed)
(6) The 'extreme' side-effects of antidepressants By Lesley Ashmall
Depression is a common psychological disease that affects your normal feeling, thinking and reacting to events that occur daily in your life.
People with depression may feel ashamed or afraid to ask for help. others suffer in silence.
According to the statistic of the World Health Organization, 300 million people around the world have depression. The numbers of Americans suffer from depression are increasing at an alarming rate. As of today, 16.2 million adults in the United States or 6.7% of all adults have depression in the country.
Women are more susceptible to develop depression than men and fewer than half of those affected by depression in the world is seeking professional treatment.
The disease is the leading cause of disability worldwide, and a major contributor to the overall global burden of diseases.
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million
Contrary to some misconceptions, depression can be treated and avoidable.
What cause depression? is debatable, however, genetic predisposition, personality, stress and brain chemistry are found to associate to the onset of the disease.
Chronic medical conditions also can trigger the development of depression. According to the study by the Shanghai University of Sport in the review of 60 articles with a total of 4311 patients, chronic diseases are highly correlated to the expression of depression and reduced quality of life(5).
The study also suggested that increasing SF-36 physical function subscale in such patients in short and long term may have a profound and positive effect in ameliorated depression and improved quality of life.
The use of antidepressants by conventional medicine may be effective. However, they can induce side effects of an upset stomach, insomnia, sexual problems, anxiety, dizziness,....., and fatigue.
In severe cases, the intake of depressants may cause serotonin syndrome, seizures, irregular heartbeat, and unconsciousness and some people in the group under the age of 25 may experience suicidal thoughts, according to the BBC report By Lesley Ashmall(6).
Asparagus is a flowering plant, belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and Western Asia.
The vegetable has been used from early times as a food and medicine, because of its delicate flavor and diuretic properties.
In an oral administration of methanolic extract of roots of AR (MAR) of the doses of 100, 200, and 400 mg/kg daily for 7 days and then subjected to forced swim test(FST) in mice, researchers found that application of the extract decreases immobility in FST and increases avoidance response in learned helplessness test (LH), an indication of antidepressant activity.
Dr. Singh GK, the lead author said, " MAR had an insignificant effect on l-DOPA-induced aggressive behavior indicating the absence of activity on the dopaminergic system" and "MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems and augmentation of antioxidant defenses".
Furthermore, the injection of extracts of Asparagus cochinchinensis (AC) also expressed antidepressive effects, through inhibited oxidative stress that cause neuron cell damage and improve cell signal response and signal transmitting.
Total saponin isolated from AC significantly is found to inhibit the free radical of H2O2 in the induction of cell death in cultured cortical neurons.
Additional analysis suggested that AC antidepressant-like and neuroprotective (reducing infarct size) effects are associated with the activation of Shp-2 pathways which are associated with the inhibition of depression in an animal model.
Some researchers suggested that antidepressant activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitters system, and cognitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system...
Moreover, the study also showed that AR may be used as food and have potential drug-drug, drug-food, and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending a message between neurons, induced protective activities against the development of depression.
These results suggested that asparagus ameliorated depression with its neuroprotective effect by inhibited free radical that cause neuro cells damage and improved cell signal response.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-depression possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)
(5) Effect of traditional Chinese exercise on the quality of life and depression for chronic diseases: a meta-analysis of randomised trials by Wang X1,2, Pi Y3, Chen B1, Chen P1, Liu Y4, Wang R4, Li X1, Zhu Y5, Yang Y6, Niu Z(PubMed)
(6) The 'extreme' side-effects of antidepressants By Lesley Ashmall
Tuesday, October 13, 2020
Fennel, The Functional Herb Which Processes Anxiolytic Property Similar to Those of Diazepam with No Adverse Effects, Scientists Find
Fennel may have a therapeutic effect in reducing the risk and treatment of anxiety, some scientists suggested.
Anxiety is a psychological problem caused by significant feelings of anxiety and fear of the present and future events.
In conventional medicine, an anxiolytic also known as an antianxiety agent including buspirone (BuSpar), trazodone, venlafaxine, and several of the benzodiazepines, is a medication used to reduce physical and psychological symptoms of anxiety disorder.
Anxiety is caused by a combination of several factors. However, stress directly from all sources is considered a major cause of the disease.
Other causes of anxiety include the longterm use of illicit drugs, medication intake, and medical condition and diseases associated with reduced lung functioning
Although medication may be effective, however, short and long-term use can cause symptoms of nausea. nervousness, dizziness, reduced sexual desire, insomnia.
In severe cases, the medicine can also cause blurred vision. confusion, nightmare, and difficulty thinking or remembering.
If you are taking the above medicine, please make sure that you understand all the side effects.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the investigate of the anxiolytic activity of ethanolic extracts of Foeniculum vulgare fruit by elevated plus maze, rotarod, open field test, and hole board models, researchers found that application of fennel extracts in the does of100-200mg/kg exerts a significant anti-anxiolytic activity, similar to those of standard anxiolytic drugs diazepam (1mg/kg) without inducing intolerable adverse effects.
This result was observed by the increased number of entries and time spent in the open arm in the elevated plus-maze apparatus.
And, application the same doses also promoted a number of rearings, assisted rearing and number of square crossed viewed by an open field test.
Further analysis also discovered that of fennel extracts also processes a potent skeletal muscle relaxant effect assessed by rotarod.
Additionally, in the experiment of the elevated plus maze, rotarod, open field, and hole board used in the evaluation of the psychomotor performance and emotional aspects of rodents removed from their acclimatized cage and placed in an environment express anxiety and fear, application of fennel extract, researchers indicated that
* Fennel injection group decreases anxiety-related behavior to an open area.
* Treated rodents exhibit a significant increase in the number of open arm entries and rearings, time spent in the center and line crossing, and head dipping.
* Fennel extract-treated group also reduces numbers of time of falling through increased muscle relaxant and improved locomotor function.
These results not only are given the supports to the holistic use of fennel in the treatment of anxiety but also reconfirmed the efficacy of fennel extract in reducing levels of anxiety in tested rodents who were placed in the environment with an expression of anxiety and fear in the first study.
Truly, the viability of above is also reaffirmed by the study conducted by the Geethanjali College of pharmacy in adult Swiss albino male mice randomly divided into six groups (n = 6).
According to the results of the analysis of groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), groups III to VI received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, mice groups treated with 50, 100, and 200 and 400 mg/kg displayed a significant reduction of anxiety score through an expression of all tests, including elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and other various parameters in doses dependent manner.
Compared to a higher dose of 400 mg/kg and lower dose treatment group, the application of 100 and 200 mg/kg dose of fennel essential oil mice demonstrated a strong decrease in anxiety through increased percent number of entries and time spent in open arms.
Compared to other doses of the treatment group, the administration of 200 mg/kg dose significantly increased the number of squares crossed at the center in the OFT test.
Furthermore, although the injection of 100 and 200 mg/kg doses of the essential oil-treated mice showed a significant reduction of rearing compared to another group, only the 200 mg/kg dose of the oil expressed a statistically significant reduction in rearing compared with diazepam, the conventional medicine used for the treatment of anxiety.
The discovery in the study postulated that fennel essential oil may have a potential effect in reducing anxiety nonlinearly and doses dependently.
"Fennel extract may possess anxiolytic activity supporting its traditional claim about anxiolytic activity", reported in the 19th edition of Pharmacology and Pharmacotherapeutics by Sathodkar, Bhandarkar, and Rege.
Taken all together, there is no doubt that fennel extracts and essential oil may be considered a secondary therapeutic treatment compared to standard medicine in the treatment of anxiety.
However, the intake of fennel supplements should be taken with extreme care in the prevention of toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE IN MICE MODEL Research Article R. NAGA KISHORE by Cheeryal (V), Keesara (M), N. ANJANEYULU, M. NAGA GANESH AND N. SRAVYA(International (Journal of Pharmacy and Pharmaceutical Sciences)
(2) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Miraf Mesfin, Kaleab Asres, and Workineh Shibeshi(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Anxiety is a psychological problem caused by significant feelings of anxiety and fear of the present and future events.
In conventional medicine, an anxiolytic also known as an antianxiety agent including buspirone (BuSpar), trazodone, venlafaxine, and several of the benzodiazepines, is a medication used to reduce physical and psychological symptoms of anxiety disorder.
Anxiety is caused by a combination of several factors. However, stress directly from all sources is considered a major cause of the disease.
Other causes of anxiety include the longterm use of illicit drugs, medication intake, and medical condition and diseases associated with reduced lung functioning
Although medication may be effective, however, short and long-term use can cause symptoms of nausea. nervousness, dizziness, reduced sexual desire, insomnia.
In severe cases, the medicine can also cause blurred vision. confusion, nightmare, and difficulty thinking or remembering.
If you are taking the above medicine, please make sure that you understand all the side effects.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the investigate of the anxiolytic activity of ethanolic extracts of Foeniculum vulgare fruit by elevated plus maze, rotarod, open field test, and hole board models, researchers found that application of fennel extracts in the does of100-200mg/kg exerts a significant anti-anxiolytic activity, similar to those of standard anxiolytic drugs diazepam (1mg/kg) without inducing intolerable adverse effects.
This result was observed by the increased number of entries and time spent in the open arm in the elevated plus-maze apparatus.
And, application the same doses also promoted a number of rearings, assisted rearing and number of square crossed viewed by an open field test.
Further analysis also discovered that of fennel extracts also processes a potent skeletal muscle relaxant effect assessed by rotarod.
Additionally, in the experiment of the elevated plus maze, rotarod, open field, and hole board used in the evaluation of the psychomotor performance and emotional aspects of rodents removed from their acclimatized cage and placed in an environment express anxiety and fear, application of fennel extract, researchers indicated that
* Fennel injection group decreases anxiety-related behavior to an open area.
* Treated rodents exhibit a significant increase in the number of open arm entries and rearings, time spent in the center and line crossing, and head dipping.
* Fennel extract-treated group also reduces numbers of time of falling through increased muscle relaxant and improved locomotor function.
These results not only are given the supports to the holistic use of fennel in the treatment of anxiety but also reconfirmed the efficacy of fennel extract in reducing levels of anxiety in tested rodents who were placed in the environment with an expression of anxiety and fear in the first study.
Truly, the viability of above is also reaffirmed by the study conducted by the Geethanjali College of pharmacy in adult Swiss albino male mice randomly divided into six groups (n = 6).
According to the results of the analysis of groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), groups III to VI received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, mice groups treated with 50, 100, and 200 and 400 mg/kg displayed a significant reduction of anxiety score through an expression of all tests, including elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and other various parameters in doses dependent manner.
Compared to a higher dose of 400 mg/kg and lower dose treatment group, the application of 100 and 200 mg/kg dose of fennel essential oil mice demonstrated a strong decrease in anxiety through increased percent number of entries and time spent in open arms.
Compared to other doses of the treatment group, the administration of 200 mg/kg dose significantly increased the number of squares crossed at the center in the OFT test.
Furthermore, although the injection of 100 and 200 mg/kg doses of the essential oil-treated mice showed a significant reduction of rearing compared to another group, only the 200 mg/kg dose of the oil expressed a statistically significant reduction in rearing compared with diazepam, the conventional medicine used for the treatment of anxiety.
The discovery in the study postulated that fennel essential oil may have a potential effect in reducing anxiety nonlinearly and doses dependently.
"Fennel extract may possess anxiolytic activity supporting its traditional claim about anxiolytic activity", reported in the 19th edition of Pharmacology and Pharmacotherapeutics by Sathodkar, Bhandarkar, and Rege.
Taken all together, there is no doubt that fennel extracts and essential oil may be considered a secondary therapeutic treatment compared to standard medicine in the treatment of anxiety.
However, the intake of fennel supplements should be taken with extreme care in the prevention of toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE IN MICE MODEL Research Article R. NAGA KISHORE by Cheeryal (V), Keesara (M), N. ANJANEYULU, M. NAGA GANESH AND N. SRAVYA(International (Journal of Pharmacy and Pharmaceutical Sciences)
(2) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Miraf Mesfin, Kaleab Asres, and Workineh Shibeshi(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Saturday, October 10, 2020
Cranberry, the Best in Hyperglycemia Management Against Diabetics Complications
Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose.
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.
Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.
Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including high-fat diet and physical inactivity.
According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.
Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.
Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.
Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrolled diet, physical inactivity, miss-medication, and improper use of insulin injection.
Uncontrolled diabetes or hyperglycemia over the long-term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.
Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) have been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.
In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.
Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".
And, "With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.
In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.
Low levels of α-amylase have been found in patients with diabetes.
α-glucosidase is associated with the digestion of carbohydrates is elevated in patients with disbetes
According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders.
Furthermore, increased with increased dose (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.
At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.
Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.
Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".
Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.
Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.
Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including high-fat diet and physical inactivity.
According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.
Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.
Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.
Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrolled diet, physical inactivity, miss-medication, and improper use of insulin injection.
Uncontrolled diabetes or hyperglycemia over the long-term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.
Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) have been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.
In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.
Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".
And, "With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.
In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.
Low levels of α-amylase have been found in patients with diabetes.
α-glucosidase is associated with the digestion of carbohydrates is elevated in patients with disbetes
According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders.
Furthermore, increased with increased dose (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.
At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.
Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.
Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".
Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)
Friday, October 9, 2020
Herbal Angelica May Suppress the Symptoms of Osteoarthritis
Osteoarthritis (OA) is a form of arthritis, found in the general term of musculoskeletal disorders (MSDs) characterized by wear and tear on joints.
The chronic and medical condition affects over 25 million people in the United States alone.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. Therefore one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), compared to other types of arthritis.
Furthermore, the pain usually gets worse ina change of weather, at night, and in the advanced diseases, and the pain can occur even at rest.
In contrast to the general belief, osteoarthritis only damages the joints of hands, knees, but also cause inflammation of the joints in your hips and spine.
The condition is a slow development disease, often starts in the 40s and 50s, and affects almost all people to some degree by age 80.
The common risk factors of osteoarthritis are aging, gender, improper healing of injured joint at a young age, obesity, and bone deformity. However, people who have a job with tasks that place repetitive stress on a particular joint are associated with the onset of osteoarthritis in most industrial countries.
According to the statistic from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% in men and 13% in women.
Epidemiological strongly suggested that obese and overweight which have a strong impact on the weight-bearing joints, the genetic preposition of a patient can make such patient more susceptible to the disease compared to others do not. People with a joint injury that did heal properly in the younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting, or other movements and the increase in age are associated with the increased risk of the onset of the disease.
On finding a natural ingredient for the prevention and treatment of aging-related diseases, scientists examined the angelica phytochemical, sodium ferulate, and a polysaccharide fraction on osteoarthritis animal models or in human chondrocytes stimulated by the pro-inflammatory cytokine, Interleukine-1β.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the results of the experiment* Sodium ferulate found in angelica exhibited marked anti-inflammatory and anti-apoptotic properties by inhibiting the TNF/TNFR signal transduction pathway associated with inflammation and autoimmunity.
* On another hand, the polysaccharide fraction which contains a mixture of various carbohydrates was found to promote proteoglycan biosynthesis in the cartilage matrix by stimulating the activity of the UDP-glycosyltransferases that synthesize the chondroitin sulfate chains of aggrecans.
In other words, both chemical compounds demonstrated strong protective effects against osteoarthritis through different mechanisms.
based on the findings, researchers said, "the combined action of sodium ferulate and polysaccharides fraction would prevent cartilage destruction in osteoarthritis and favor cartilage repair".
Taken altogether, herbal angelica may be considered an antioxidant remedy for the treatment of osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Angelica sinensis and osteoarthritis: a natural therapeutic link? by Magdalou J1, Chen LB2, Wang H3, Qin J2, Wen Y2, Li XJ3, Shang L3, Li J. (PubMed)
The chronic and medical condition affects over 25 million people in the United States alone.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. Therefore one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), compared to other types of arthritis.
Furthermore, the pain usually gets worse ina change of weather, at night, and in the advanced diseases, and the pain can occur even at rest.
In contrast to the general belief, osteoarthritis only damages the joints of hands, knees, but also cause inflammation of the joints in your hips and spine.
The condition is a slow development disease, often starts in the 40s and 50s, and affects almost all people to some degree by age 80.
The common risk factors of osteoarthritis are aging, gender, improper healing of injured joint at a young age, obesity, and bone deformity. However, people who have a job with tasks that place repetitive stress on a particular joint are associated with the onset of osteoarthritis in most industrial countries.
According to the statistic from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% in men and 13% in women.
Epidemiological strongly suggested that obese and overweight which have a strong impact on the weight-bearing joints, the genetic preposition of a patient can make such patient more susceptible to the disease compared to others do not. People with a joint injury that did heal properly in the younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting, or other movements and the increase in age are associated with the increased risk of the onset of the disease.
On finding a natural ingredient for the prevention and treatment of aging-related diseases, scientists examined the angelica phytochemical, sodium ferulate, and a polysaccharide fraction on osteoarthritis animal models or in human chondrocytes stimulated by the pro-inflammatory cytokine, Interleukine-1β.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the results of the experiment* Sodium ferulate found in angelica exhibited marked anti-inflammatory and anti-apoptotic properties by inhibiting the TNF/TNFR signal transduction pathway associated with inflammation and autoimmunity.
* On another hand, the polysaccharide fraction which contains a mixture of various carbohydrates was found to promote proteoglycan biosynthesis in the cartilage matrix by stimulating the activity of the UDP-glycosyltransferases that synthesize the chondroitin sulfate chains of aggrecans.
In other words, both chemical compounds demonstrated strong protective effects against osteoarthritis through different mechanisms.
based on the findings, researchers said, "the combined action of sodium ferulate and polysaccharides fraction would prevent cartilage destruction in osteoarthritis and favor cartilage repair".
Taken altogether, herbal angelica may be considered an antioxidant remedy for the treatment of osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Angelica sinensis and osteoarthritis: a natural therapeutic link? by Magdalou J1, Chen LB2, Wang H3, Qin J2, Wen Y2, Li XJ3, Shang L3, Li J. (PubMed)
Wednesday, October 7, 2020
Herbal Angelica Induces Apoptosis of Human Neuroblastoma Cells
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role in processing and transmitting the information.
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.
Cancer most commonly affects children age 5 or younger compared to less often in older children.
According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.
And 90% of children affected by neuroblastoma are younger than 5.
Sadly, the the-5-year survival rate of cancer is less than 50%.
Most common symptoms are totally depending on the area that has been effected
* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched and changes in bowel habits, such as diarrhea or constipation.
* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain and changes to the eyes, including drooping eyelids and unequal pupil size
Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.
On finding a natural ingredient for the prevention and treatment of brain cancer, scientists examined the effects of Angelica polymorpha Maxim root extract (APRE) cytotoxicity on neuroblastoma cells (NB).
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the final results of the experiment,
* APRE reduced cell viability in NB to a greater extent than in fibroblast cells.
* APRE could inhibit proteins and down-regulated pathways associated with cancer cell proliferation and survival.
* Furthermore, APRE promoted pro-apoptotic protein and inhibited the expression of proteins associated with anti-apoptosis.
* Moreover, APRE depolarized the mitochondria membrane potential and activation of caspase-3 associated with the cell death in the SH-SY5Y cells.
Additional differentiation, researchers said, "APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved".
Taken altogether, herbal angelica may be considered a remedy for the treatment of neuroblastoma, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway by Rahman MA1, Bishayee K1, Huh SO. (PubMed)
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role in processing and transmitting the information.
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.
Cancer most commonly affects children age 5 or younger compared to less often in older children.
According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.
And 90% of children affected by neuroblastoma are younger than 5.
Sadly, the the-5-year survival rate of cancer is less than 50%.
Most common symptoms are totally depending on the area that has been effected
* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched and changes in bowel habits, such as diarrhea or constipation.
* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain and changes to the eyes, including drooping eyelids and unequal pupil size
Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.
On finding a natural ingredient for the prevention and treatment of brain cancer, scientists examined the effects of Angelica polymorpha Maxim root extract (APRE) cytotoxicity on neuroblastoma cells (NB).
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the final results of the experiment,
* APRE reduced cell viability in NB to a greater extent than in fibroblast cells.
* APRE could inhibit proteins and down-regulated pathways associated with cancer cell proliferation and survival.
* Furthermore, APRE promoted pro-apoptotic protein and inhibited the expression of proteins associated with anti-apoptosis.
* Moreover, APRE depolarized the mitochondria membrane potential and activation of caspase-3 associated with the cell death in the SH-SY5Y cells.
Additional differentiation, researchers said, "APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved".
Taken altogether, herbal angelica may be considered a remedy for the treatment of neuroblastoma, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway by Rahman MA1, Bishayee K1, Huh SO. (PubMed)
Tuesday, October 6, 2020
Chaste Tree Berry, The Best Hepatoprotective Whole Herb Medicine
Chaste tree beery is found to associate with reduced risk of liver damage and diseases through various mechanisms, the recent study suggested
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
In acetaminophen-induced hepatotoxicity in mice study, oral administration of chaste tree berry increased significantly in the expression of levels of antioxidant in inhibition of free radicals domino' effect and levels of ferric ion in induced hepatotoxicity caused by acetaminophen.
According to the Al-Hikmah University, Hepatoprotective effects of chaste tree berry may also mediate the alternative effects of acetaminophen in serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin, and total bilirubin levels which can also contribute to hepatoxicity.
Dr. Ajiboye TO said, " Vitex doniana fruits possess antioxidant properties and halted acetaminophen-mediated oxidative rout on cellular proteins, lipids and DNA, made possible by β-sitosterol, platycodin D, apigenin, saikosaponin, chrysin and ellagitanin, (the antioxidants) in the extract".
Furthermore, ethanol extract Vitex glabrata (EEVG) on carbon tetrachloride-induced liver damage in rats, .displayed also antioxidant activity in inhibited superoxide dismutase, GSH, lipid peroxidation (LPO), catalase, and peroxidase levels in liver homogenate.
Pre-treatment of the extract illustrated a strong inhibited effect against levels of LPO in CCl(4)-intoxicated livers and reduced the elevated serum levels of chemical compounds which can cause liver damage
In fact, the extract displays an enormous hepaprotective effect similar to those of silymarin through enhancing antioxidant mechanisms of its components, predominantly artemetin.
According to the The Vinayaka Mission’s College of Pharmacy study, in the CCl4 induced hepatic injury in albino rats, vitex extract not only is comparable to the standard drug, silymarin (100 mg/kg, p.o.), but also altered serum biomarker enzyme levels which were damage through injection of CCI4, to near normal in treated rats.
Taking together, there is no doubt that Chaste tree berry may process a protective effect in reduced risk of harmful chemicals and drugs induced liver damage, but the injection of the large amount should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen-induced hepatotoxicity by Ajiboye TO1.(PubMed)
(2) Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats by Sridevi VK1, Chouhan HS, Singh NK, Singh SK.(PubMed)
(3) Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats by Anandan R1, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS.(PubMed)
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
In acetaminophen-induced hepatotoxicity in mice study, oral administration of chaste tree berry increased significantly in the expression of levels of antioxidant in inhibition of free radicals domino' effect and levels of ferric ion in induced hepatotoxicity caused by acetaminophen.
According to the Al-Hikmah University, Hepatoprotective effects of chaste tree berry may also mediate the alternative effects of acetaminophen in serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin, and total bilirubin levels which can also contribute to hepatoxicity.
Dr. Ajiboye TO said, " Vitex doniana fruits possess antioxidant properties and halted acetaminophen-mediated oxidative rout on cellular proteins, lipids and DNA, made possible by β-sitosterol, platycodin D, apigenin, saikosaponin, chrysin and ellagitanin, (the antioxidants) in the extract".
Furthermore, ethanol extract Vitex glabrata (EEVG) on carbon tetrachloride-induced liver damage in rats, .displayed also antioxidant activity in inhibited superoxide dismutase, GSH, lipid peroxidation (LPO), catalase, and peroxidase levels in liver homogenate.
Pre-treatment of the extract illustrated a strong inhibited effect against levels of LPO in CCl(4)-intoxicated livers and reduced the elevated serum levels of chemical compounds which can cause liver damage
In fact, the extract displays an enormous hepaprotective effect similar to those of silymarin through enhancing antioxidant mechanisms of its components, predominantly artemetin.
According to the The Vinayaka Mission’s College of Pharmacy study, in the CCl4 induced hepatic injury in albino rats, vitex extract not only is comparable to the standard drug, silymarin (100 mg/kg, p.o.), but also altered serum biomarker enzyme levels which were damage through injection of CCI4, to near normal in treated rats.
Taking together, there is no doubt that Chaste tree berry may process a protective effect in reduced risk of harmful chemicals and drugs induced liver damage, but the injection of the large amount should be taken with care.
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Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen-induced hepatotoxicity by Ajiboye TO1.(PubMed)
(2) Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats by Sridevi VK1, Chouhan HS, Singh NK, Singh SK.(PubMed)
(3) Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats by Anandan R1, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS.(PubMed)
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