Fennel may process a strong anti-inflammatory activity in reducing the risk of tissue injury and cell apoptosis, some scientists suggested.
Acute inflammation is a natural and systematic immune response to protect our body against the invasion of foreign bacteria and viruses by the initiated production of inflammatory cytokines to the site of infection.
However, overproduction of pro-inflammatory cytokines initiated by the immune system for a prolonged period of time may lead to cell damage and sometimes death of the healthy cells in the infectious site and nearby cells.
These complications can also cause improper healing for the forming of scars and damage to the tissue of the organ, affecting and limiting the organs functioning, such as liver scars caused by hepatitis virus infection.
Badly enough, some proteins process the duo functions of pro and anti-inflammation. Under abnormal conditions, they can switch from their original action of anti-inflammatory cytokines to pro-inflammatory cytokines.
Furthermore, chronic inflammation occurred that lasts for months or years when the immune system response to the site of infection failure to eliminate agents that cause acute inflammation.
An autoimmune disorder that attacks normal healthy tissue, mistaking them for pathogens that can also cause chronic inflammatory disease.
Most cases of inflammation, are treated with NSAID's, or non-steroidal anti-inflammatory drugs. However, in some people intake of these medications can cause common and serious side effects, including gastrointestinal issues, such as pain, constipation, diarrhea, gas, nausea, and stomach ulcers, kidney problems, anemia,.... and swelling in the leg.
If you are presently taking anti-inflammatory medicine, please make sure that you discuss the adverse effects with your doctor.
Fennel (Foeniculum vulgare) is a plant species, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.
Herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle, and relieve PMS,...
According to a study of BALB/C mice were intraperitoneally administered anethole (62.5, 125, 250, or 500 mg/kg) 1 h before intratracheal treatment with LPS (1.5 mg/kg) and sacrificed after 4 h, researchers found that in the anethole treatment group exerts a significant increase of numbers of mobile white blood cells macrophages and neutrophils, the first immune response to the infectious site.
Furthermore, the application of LPS also induced the production of inflammatory mediators such as matrix metalloproteinase 9 (MMP-9), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) all systematic inflammatory cytokines in response to cellular damage and tissue injury.
Moreover, LPS also exhibited the overproduction of nitric oxide (NO) observed in bronchoalveolar lavage fluid in facilitated cellular cytotoxicity.
In the compared nontreatment group, the injection anethole group demonstrated a strong anti-inflammatory effect through decrease activities of proinflammatory factors without affecting the immune activity in protects against infection.
Additional analysis also found that the treatment group reduced acute lung injury caused by injection LPS through its antioxidants and induced production of host natural antioxidants in the body tissue.
The inhibited LPS results were attributed to anethole effect in suppressed the activation of NF-κB in signaling the production of inflammatory cytokines by blocking the initiation of IκB-α degradation by inhibited TRAF2 in the induction of inflammation through TNF receptor superfamily members and NIK, a key signaling molecule of the noncanonical NF-κB.
Interestingly, further investigation of anethole as an inhibitor of TNF-induced NF-kB activation (an early response) as monitored by electrophoretic mobility shift assay, by suppression of IkBa phosphorylation and NF-kB reporter gene, researchers also indicated that
* Anethole also suppressed TNF-induced activation of the transcription factor AP-1 in regulated gene expression in response to a variety of stimuli, including LPS application.
*c-Jun N-terminal kinases (JNKs) with function in response to stress stimuli, such as cytokines,
And
* MAPKkinase in signal inflammatory response through transmitting information from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
* Application of anethole also suppressed TNF-induced both lipid peroxidation and ROS generation, through the stimulated production of natural antioxidants in the host and itself, resulting in balancing the ratio of antioxidant and ROS expression.
The illustration and differentiation were elite by the experiment in the application of TNF (100 pM) with the cells pretreated for 240 and 120 min with anethole, NF-kB activation was almost completely inhibited.
However, the inhibition decreased gradually with decreased pre-incubation time.
Taken together, fennel and its bioactive anethole may be considered as a functional food in reduced risk and treatment in acute and chronic inflammatory related-diseases through the properties like a pro antioxidant and anti-inflammatory agent.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice
by PurumKanga1Ka YoungKima1Hui SuLeea1Sun SeekMinbGeun HeeSeol(PubMed)
(2) Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: e€ffect on NF-kB, AP-1, JNK, MAPKK and apoptosis by Gagan BN Chainy1,2, Sunil K Manna1,2, Madan M Chaturvedi1 and Bharat B Aggarwal by Oncogene (2000) 19, 2943 ± 2950 ã 2000 Macmillan Publishers Ltd All rights reserved 0950 ± 9232/00 $15.00
Friday, January 1, 2021
Friday, December 4, 2020
Cranberry Promotes the Cardio-Metabolic Health
Cardiometabolic risk is a condition that estimates the possibility of developing atherosclerotic cardiovascular (CV) disease and diabetes mellitus.
Cardioprotection is a process including the use of substances associated with the preservation of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.
Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage of blood vessels and the heart.
More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack), or stroke, depending on the location of the blockage or disruption,
According to the statistics provided by the American Heart Association, approximately 84 million people in this US living with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.
Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.
Depending on the location of the blockage, if the reduced blood flow occurred in the brain, it will cause the death of the brain cells, leading to stroke.
However, if the reduced blood flow occurred in the heart, it will cause damage to the heart tissues, leading to heart disease.
Most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium and other chemical substances in the artery
Most people with atherosclerosis are asymptomatic at the early stage.
Diabetes is a medical condition characterized by insufficient insulins in the bloodstream. or insulins in the bloodstream are not used properly to convert glucose to energy.
Epidemiologically, diabetes is caused by either the beta cells in the pancreas died-off or insulin receptors with a function that use insulin to convert glucose to energy clogged-up by fat or cholesterol.
In a healthy individual, after eating, the rise of blood glucose triggers the production of insulin by the pancreas into the bloodstream After you eat, your blood sugar (glucose) rises. This rise in glucose triggers your pancreas to release insulin into the bloodstream that travels through the blood to your body's cells before converting glucose into energy or store it to use later.
In other words, insulin released by the pancreas joints with the Insulin receptors on the outer part of a cell that binds insulin in the blood to convert glucose to energy.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cardiometabolic health, researchers examined the effect of Vaccinium berry fruit in modulating gut microbiota function and cardiometabolic risk factors.
In cardiometabolic health, cranberry constituents and their bioactive catabolites improved the
serum lipid profiles reduced the levels of blood pressure.
Furthermore, the endothelial functions associated with vascular relaxation and contraction, glucoregulation involved in the regulation of glucose metabolism. and a variety of biomarkers associated with inflammation and oxidative stress in the induction of CVD and diabetes were also inhibited by the cranberry constituents and their bioactive catabolites
Based on the findings, researchers said, " These results warrant further research, particularly studies dedicated to the elucidation of dose-response relations, pharmacokinetic/metabolomics profiles, and relevant biomarkers of action with the use of fully characterized cranberry products.".
Taken altogether, cranberry may be considered a remedy for the improvement of cardiometabolic health, pending the confirmation of the larger sample size, and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MA4, Neto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)
Cardioprotection is a process including the use of substances associated with the preservation of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.
Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage of blood vessels and the heart.
More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack), or stroke, depending on the location of the blockage or disruption,
According to the statistics provided by the American Heart Association, approximately 84 million people in this US living with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.
Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.
Depending on the location of the blockage, if the reduced blood flow occurred in the brain, it will cause the death of the brain cells, leading to stroke.
However, if the reduced blood flow occurred in the heart, it will cause damage to the heart tissues, leading to heart disease.
Most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium and other chemical substances in the artery
Most people with atherosclerosis are asymptomatic at the early stage.
Diabetes is a medical condition characterized by insufficient insulins in the bloodstream. or insulins in the bloodstream are not used properly to convert glucose to energy.
Epidemiologically, diabetes is caused by either the beta cells in the pancreas died-off or insulin receptors with a function that use insulin to convert glucose to energy clogged-up by fat or cholesterol.
In a healthy individual, after eating, the rise of blood glucose triggers the production of insulin by the pancreas into the bloodstream After you eat, your blood sugar (glucose) rises. This rise in glucose triggers your pancreas to release insulin into the bloodstream that travels through the blood to your body's cells before converting glucose into energy or store it to use later.
In other words, insulin released by the pancreas joints with the Insulin receptors on the outer part of a cell that binds insulin in the blood to convert glucose to energy.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cardiometabolic health, researchers examined the effect of Vaccinium berry fruit in modulating gut microbiota function and cardiometabolic risk factors.
In cardiometabolic health, cranberry constituents and their bioactive catabolites improved the
serum lipid profiles reduced the levels of blood pressure.
Furthermore, the endothelial functions associated with vascular relaxation and contraction, glucoregulation involved in the regulation of glucose metabolism. and a variety of biomarkers associated with inflammation and oxidative stress in the induction of CVD and diabetes were also inhibited by the cranberry constituents and their bioactive catabolites
Based on the findings, researchers said, " These results warrant further research, particularly studies dedicated to the elucidation of dose-response relations, pharmacokinetic/metabolomics profiles, and relevant biomarkers of action with the use of fully characterized cranberry products.".
Taken altogether, cranberry may be considered a remedy for the improvement of cardiometabolic health, pending the confirmation of the larger sample size, and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MA4, Neto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)
Friday, October 23, 2020
Honey, the Natural Whole Food for Prevention and Treatment of Dandruff
Honey may have a potential effect in the prevention and treatment of dandruff, a common skin problem of many adults, some scientists suggested
Dandruff is a condition of the scalp most commonly caused by the dry skin resulting from dry air.
However, in many instances, the condition also is associated with seborrheic dermatitis. leading to rough, scaly skin on the scalp.
In other words, patients with oily skin accompanied by seborrheic dermatitis can lead to overexpression of yeast that causes the development of the large white flakes or yellow scales due to uneven shedding and clumping of dead skin cells.
Belief or not dandruff affects over 50% of the general population.
There are many causes of dandruff. Researchers suggested that dry skin, use of wrong kinds of hair products and skin conditions such as seborrheic dermatitis or eczema are associated with the onset of dandruff.
In some people, an overgrowth of a yeast-like fungus can also cause dandruff.
The increase of age hormone imbalance and prolonged periods of stress are the most common prevalent risk factors associated with the condition.
Most cases of dandruff can be treated with daily shampoo to reduce the oil on the scalp. In severe cases, due to overexpression of fungi, pyrithione zinc shampoos may be recommended.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Dandruff, if left untreated can cause itchy and inflamed scalp that it lead to temporary hair loss.
On finding a natural ingredient for the prevention and treatment of dandruff with no side effects, researchers examine the anti-dandruff effects from honey, a bee-derived, supersaturated solution composed mainly of fructose and glucose, and contains proteins and amino acids, vitamins, enzymes, minerals, and other minor components.
The application of honey exerted a significant effect in reducing dandruff, through its moisturizing and antimicrobial property.
The effective doses range between 1 and 10%, but concentrations up to 70% can be reached by mixing with oils, gel, and emulsifiers, or polymer entrapment.
With an aim to reaffirming the honey anti-dandruff activity, a researcher at the Dubai Specialised Medical Centre and Medical Research Labs, investigated the potential use of topical application of crude honey in the management of seborrheic dermatitis and dandruff.
The study included 30 patients (20 patients were males and 10 were females, their ages ranged between 15 and 60 years) with chronic seborrheic dermatitis of the scalp, face, and front of the chest.
Before applying honey to treat the condition, participants showed conditions of scaling, itching, and hair loss. The lesions were scaling macules, papules, and dry white plaques with crust and fissures.
All patients were asked to apply diluted crude honey (90% honey diluted in warm water) every other day on the lesions with gentle rubbing for 2-3 mins. And, honey was left for 3 hr before gentle rinsing with warm water.
After 4 weeks of treatment, honey showed a significant effect on the prophylactic phase, which lasted for six months.
Furthermore, half of the patients treated with the topical honey once weekly and the other half served as control.
The treatment group demonstrated a reduction of Itching and disappeared scaling within one week. Skin lesions were healed and disappeared completely within 2 weeks.
Moreover, honey administration also improved in hair loss.
None of the patients treated with the honey application once weekly experienced a relapse for six months
Dr. Al-Waili NS, after taking into account co and confounders, said, "crude honey could markedly improve seborrheic dermatitis and associated hair loss and prevent relapse when applied weekly".
The findings clearly suggested that honey may be considered a replacement of chemical ingredients for the prevention and treatment of dandruff associated with seborrheic dermatitis, with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Honey in dermatology and skin care: a review by Burlando B1, Cornara L.(PubMed)
(2) Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff by Al-Waili NS1. (PubMed)
Dandruff is a condition of the scalp most commonly caused by the dry skin resulting from dry air.
However, in many instances, the condition also is associated with seborrheic dermatitis. leading to rough, scaly skin on the scalp.
In other words, patients with oily skin accompanied by seborrheic dermatitis can lead to overexpression of yeast that causes the development of the large white flakes or yellow scales due to uneven shedding and clumping of dead skin cells.
Belief or not dandruff affects over 50% of the general population.
There are many causes of dandruff. Researchers suggested that dry skin, use of wrong kinds of hair products and skin conditions such as seborrheic dermatitis or eczema are associated with the onset of dandruff.
In some people, an overgrowth of a yeast-like fungus can also cause dandruff.
The increase of age hormone imbalance and prolonged periods of stress are the most common prevalent risk factors associated with the condition.
Most cases of dandruff can be treated with daily shampoo to reduce the oil on the scalp. In severe cases, due to overexpression of fungi, pyrithione zinc shampoos may be recommended.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Dandruff, if left untreated can cause itchy and inflamed scalp that it lead to temporary hair loss.
On finding a natural ingredient for the prevention and treatment of dandruff with no side effects, researchers examine the anti-dandruff effects from honey, a bee-derived, supersaturated solution composed mainly of fructose and glucose, and contains proteins and amino acids, vitamins, enzymes, minerals, and other minor components.
The application of honey exerted a significant effect in reducing dandruff, through its moisturizing and antimicrobial property.
The effective doses range between 1 and 10%, but concentrations up to 70% can be reached by mixing with oils, gel, and emulsifiers, or polymer entrapment.
With an aim to reaffirming the honey anti-dandruff activity, a researcher at the Dubai Specialised Medical Centre and Medical Research Labs, investigated the potential use of topical application of crude honey in the management of seborrheic dermatitis and dandruff.
The study included 30 patients (20 patients were males and 10 were females, their ages ranged between 15 and 60 years) with chronic seborrheic dermatitis of the scalp, face, and front of the chest.
Before applying honey to treat the condition, participants showed conditions of scaling, itching, and hair loss. The lesions were scaling macules, papules, and dry white plaques with crust and fissures.
All patients were asked to apply diluted crude honey (90% honey diluted in warm water) every other day on the lesions with gentle rubbing for 2-3 mins. And, honey was left for 3 hr before gentle rinsing with warm water.
After 4 weeks of treatment, honey showed a significant effect on the prophylactic phase, which lasted for six months.
Furthermore, half of the patients treated with the topical honey once weekly and the other half served as control.
The treatment group demonstrated a reduction of Itching and disappeared scaling within one week. Skin lesions were healed and disappeared completely within 2 weeks.
Moreover, honey administration also improved in hair loss.
None of the patients treated with the honey application once weekly experienced a relapse for six months
Dr. Al-Waili NS, after taking into account co and confounders, said, "crude honey could markedly improve seborrheic dermatitis and associated hair loss and prevent relapse when applied weekly".
The findings clearly suggested that honey may be considered a replacement of chemical ingredients for the prevention and treatment of dandruff associated with seborrheic dermatitis, with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Honey in dermatology and skin care: a review by Burlando B1, Cornara L.(PubMed)
(2) Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff by Al-Waili NS1. (PubMed)
Tuesday, October 20, 2020
Herbal Turmeric Protects the Kidney Against the Onset of Lupus Nephritis
Lupus nephritis is a condition of kidneys an inflammation caused by systemic lupus erythematosus (SLE), an autoimmune disease.
It is a type of glomerulonephritis in which the glomeruli become inflamed.
Kidneys are a pair of bean-shaped organs, located just below the rib cage, one on each side of your spine with a function to filter out blood toxins through urinary secretion.
Believe it or not, every day, the blood passes the kidneys many times. Some people with only 10% of kidney function showed no symptoms of toxin accumulation.
However, if the kidney fails to cleanse the blood due to kidney failure, patients may experience symptoms of decreased urine output, fluid retention in your legs, ankles, or feet.
Depending on the severity of toxins accumulation, some patients may also experience symptoms of shortness of breath and confusion.
Lupus nephritis reduced kidney function may cause symptoms of sudden and unexplained swelling feet, ankles, legs, fingers, arms or the eyes, foamy appearance in urine, and frequent urination.
In severe cases, patients may also have symptoms of blood in urine and elevated blood pressure.
Out of many risk factors associated with the risk of lupus nephritis, some researchers suggested genetic preposition may be a strong impact that leads to the early onset of the disease.
Dr. the lead scientist wrote, " Although many SLE susceptibility genes have been identified, the genetic basis of LN is not as well understood".
And, "some of the established general SLE susceptibility genes are associated with LN, recent discoveries highlight a number of genes with renal functions that are specifically associated with LN. Some of these genes associated with LN help to explain the disparity in the prevalence of nephritis between individuals with SLE, and also partially explain differences in LN between ancestral backgrounds".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential ingredient for the treatment of lupus nephritis, researchers investigated the effects of curcumin on lupus nephritis (LN) induced animal model.
LN established New Zealand Black/White (NZB/W) F1 female mice, at 18 weeks of age were fed a standard diet or a diet containing 1 % curcumin until the end of the study.
During the study, infection of curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a which were elevated in LN mice.
Where proteinuria is the ratio of a protein/creatinine greater than 45 mg/mmol and high levels of IgG1, IgG2a is an indication of immune defect.
Additonally, curcumin also protected the kidneys against inflammation by reducing the anti-dsDNA IgG antibodies which were also elevated in NZB/W F1 female mice.
Where elevated levels of anti-dsDNA IgG antibodies are associated with ongoing inflammation and damage to the kidneys.
Furthermore, IgG immune complex deposition in the glomeruli was also reduced in curcumin-treated mice.
In other words, curcumin suppressed the pro-inflammatory expression in the kidney glomeruli.
Moreover, according to the kidney tested assays, kidney inflammation was also decreased after curcumin treatment.
More importantly, researchers discovered that treatment with anti-CD25 antibody injection that causes Treg depletion also affects the therapeutic effects of curcumin.
Where the anti-CD25 antibody is a conventional medicine used for enhancing the immune response.
More precisely, curcumin cannot be used in combination with anti-CD25 antibody daclizumab that
targets the T cells for the treatment of lupus nephritis.
Based on the findings, researchers said, "Curcumin exerted a protective effect against LN in NZB/W F1 mice. We speculate that the protective effects of curcumin in LN may involve, at least in part, its interaction with Treg cells".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of lupus nephritis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice by Lee H1, Kim H, Lee G, Chung HS, Bae H. (PubMed)
(2) Genetics of human lupus nephritis by Iwamoto T1, Niewold TB. (PubMed)
It is a type of glomerulonephritis in which the glomeruli become inflamed.
Kidneys are a pair of bean-shaped organs, located just below the rib cage, one on each side of your spine with a function to filter out blood toxins through urinary secretion.
Believe it or not, every day, the blood passes the kidneys many times. Some people with only 10% of kidney function showed no symptoms of toxin accumulation.
However, if the kidney fails to cleanse the blood due to kidney failure, patients may experience symptoms of decreased urine output, fluid retention in your legs, ankles, or feet.
Depending on the severity of toxins accumulation, some patients may also experience symptoms of shortness of breath and confusion.
Lupus nephritis reduced kidney function may cause symptoms of sudden and unexplained swelling feet, ankles, legs, fingers, arms or the eyes, foamy appearance in urine, and frequent urination.
In severe cases, patients may also have symptoms of blood in urine and elevated blood pressure.
Out of many risk factors associated with the risk of lupus nephritis, some researchers suggested genetic preposition may be a strong impact that leads to the early onset of the disease.
Dr. the lead scientist wrote, " Although many SLE susceptibility genes have been identified, the genetic basis of LN is not as well understood".
And, "some of the established general SLE susceptibility genes are associated with LN, recent discoveries highlight a number of genes with renal functions that are specifically associated with LN. Some of these genes associated with LN help to explain the disparity in the prevalence of nephritis between individuals with SLE, and also partially explain differences in LN between ancestral backgrounds".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential ingredient for the treatment of lupus nephritis, researchers investigated the effects of curcumin on lupus nephritis (LN) induced animal model.
LN established New Zealand Black/White (NZB/W) F1 female mice, at 18 weeks of age were fed a standard diet or a diet containing 1 % curcumin until the end of the study.
During the study, infection of curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a which were elevated in LN mice.
Where proteinuria is the ratio of a protein/creatinine greater than 45 mg/mmol and high levels of IgG1, IgG2a is an indication of immune defect.
Additonally, curcumin also protected the kidneys against inflammation by reducing the anti-dsDNA IgG antibodies which were also elevated in NZB/W F1 female mice.
Where elevated levels of anti-dsDNA IgG antibodies are associated with ongoing inflammation and damage to the kidneys.
Furthermore, IgG immune complex deposition in the glomeruli was also reduced in curcumin-treated mice.
In other words, curcumin suppressed the pro-inflammatory expression in the kidney glomeruli.
Moreover, according to the kidney tested assays, kidney inflammation was also decreased after curcumin treatment.
More importantly, researchers discovered that treatment with anti-CD25 antibody injection that causes Treg depletion also affects the therapeutic effects of curcumin.
Where the anti-CD25 antibody is a conventional medicine used for enhancing the immune response.
More precisely, curcumin cannot be used in combination with anti-CD25 antibody daclizumab that
targets the T cells for the treatment of lupus nephritis.
Based on the findings, researchers said, "Curcumin exerted a protective effect against LN in NZB/W F1 mice. We speculate that the protective effects of curcumin in LN may involve, at least in part, its interaction with Treg cells".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of lupus nephritis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice by Lee H1, Kim H, Lee G, Chung HS, Bae H. (PubMed)
(2) Genetics of human lupus nephritis by Iwamoto T1, Niewold TB. (PubMed)
Saturday, October 17, 2020
The Antidepression Natural Whole Food, Biomedical Literature Suggested
Scientists may have found a dietary vegetable that processes a strong and profound impact in ameliorated psychological depression, a recent study suggested.
Depression is a common psychological disease that affects your normal feeling, thinking and reacting to events that occur daily in your life.
People with depression may feel ashamed or afraid to ask for help. others suffer in silence.
According to the statistic of the World Health Organization, 300 million people around the world have depression. The numbers of Americans suffer from depression are increasing at an alarming rate. As of today, 16.2 million adults in the United States or 6.7% of all adults have depression in the country.
Women are more susceptible to develop depression than men and fewer than half of those affected by depression in the world is seeking professional treatment.
The disease is the leading cause of disability worldwide, and a major contributor to the overall global burden of diseases.
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million
Contrary to some misconceptions, depression can be treated and avoidable.
What cause depression? is debatable, however, genetic predisposition, personality, stress and brain chemistry are found to associate to the onset of the disease.
Chronic medical conditions also can trigger the development of depression. According to the study by the Shanghai University of Sport in the review of 60 articles with a total of 4311 patients, chronic diseases are highly correlated to the expression of depression and reduced quality of life(5).
The study also suggested that increasing SF-36 physical function subscale in such patients in short and long term may have a profound and positive effect in ameliorated depression and improved quality of life.
The use of antidepressants by conventional medicine may be effective. However, they can induce side effects of an upset stomach, insomnia, sexual problems, anxiety, dizziness,....., and fatigue.
In severe cases, the intake of depressants may cause serotonin syndrome, seizures, irregular heartbeat, and unconsciousness and some people in the group under the age of 25 may experience suicidal thoughts, according to the BBC report By Lesley Ashmall(6).
Asparagus is a flowering plant, belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and Western Asia.
The vegetable has been used from early times as a food and medicine, because of its delicate flavor and diuretic properties.
In an oral administration of methanolic extract of roots of AR (MAR) of the doses of 100, 200, and 400 mg/kg daily for 7 days and then subjected to forced swim test(FST) in mice, researchers found that application of the extract decreases immobility in FST and increases avoidance response in learned helplessness test (LH), an indication of antidepressant activity.
Dr. Singh GK, the lead author said, " MAR had an insignificant effect on l-DOPA-induced aggressive behavior indicating the absence of activity on the dopaminergic system" and "MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems and augmentation of antioxidant defenses".
Furthermore, the injection of extracts of Asparagus cochinchinensis (AC) also expressed antidepressive effects, through inhibited oxidative stress that cause neuron cell damage and improve cell signal response and signal transmitting.
Total saponin isolated from AC significantly is found to inhibit the free radical of H2O2 in the induction of cell death in cultured cortical neurons.
Additional analysis suggested that AC antidepressant-like and neuroprotective (reducing infarct size) effects are associated with the activation of Shp-2 pathways which are associated with the inhibition of depression in an animal model.
Some researchers suggested that antidepressant activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitters system, and cognitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system...
Moreover, the study also showed that AR may be used as food and have potential drug-drug, drug-food, and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending a message between neurons, induced protective activities against the development of depression.
These results suggested that asparagus ameliorated depression with its neuroprotective effect by inhibited free radical that cause neuro cells damage and improved cell signal response.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-depression possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)
(5) Effect of traditional Chinese exercise on the quality of life and depression for chronic diseases: a meta-analysis of randomised trials by Wang X1,2, Pi Y3, Chen B1, Chen P1, Liu Y4, Wang R4, Li X1, Zhu Y5, Yang Y6, Niu Z(PubMed)
(6) The 'extreme' side-effects of antidepressants By Lesley Ashmall
Depression is a common psychological disease that affects your normal feeling, thinking and reacting to events that occur daily in your life.
People with depression may feel ashamed or afraid to ask for help. others suffer in silence.
According to the statistic of the World Health Organization, 300 million people around the world have depression. The numbers of Americans suffer from depression are increasing at an alarming rate. As of today, 16.2 million adults in the United States or 6.7% of all adults have depression in the country.
Women are more susceptible to develop depression than men and fewer than half of those affected by depression in the world is seeking professional treatment.
The disease is the leading cause of disability worldwide, and a major contributor to the overall global burden of diseases.
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million
Contrary to some misconceptions, depression can be treated and avoidable.
What cause depression? is debatable, however, genetic predisposition, personality, stress and brain chemistry are found to associate to the onset of the disease.
Chronic medical conditions also can trigger the development of depression. According to the study by the Shanghai University of Sport in the review of 60 articles with a total of 4311 patients, chronic diseases are highly correlated to the expression of depression and reduced quality of life(5).
The study also suggested that increasing SF-36 physical function subscale in such patients in short and long term may have a profound and positive effect in ameliorated depression and improved quality of life.
The use of antidepressants by conventional medicine may be effective. However, they can induce side effects of an upset stomach, insomnia, sexual problems, anxiety, dizziness,....., and fatigue.
In severe cases, the intake of depressants may cause serotonin syndrome, seizures, irregular heartbeat, and unconsciousness and some people in the group under the age of 25 may experience suicidal thoughts, according to the BBC report By Lesley Ashmall(6).
Asparagus is a flowering plant, belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa, and Western Asia.
The vegetable has been used from early times as a food and medicine, because of its delicate flavor and diuretic properties.
In an oral administration of methanolic extract of roots of AR (MAR) of the doses of 100, 200, and 400 mg/kg daily for 7 days and then subjected to forced swim test(FST) in mice, researchers found that application of the extract decreases immobility in FST and increases avoidance response in learned helplessness test (LH), an indication of antidepressant activity.
Dr. Singh GK, the lead author said, " MAR had an insignificant effect on l-DOPA-induced aggressive behavior indicating the absence of activity on the dopaminergic system" and "MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems and augmentation of antioxidant defenses".
Furthermore, the injection of extracts of Asparagus cochinchinensis (AC) also expressed antidepressive effects, through inhibited oxidative stress that cause neuron cell damage and improve cell signal response and signal transmitting.
Total saponin isolated from AC significantly is found to inhibit the free radical of H2O2 in the induction of cell death in cultured cortical neurons.
Additional analysis suggested that AC antidepressant-like and neuroprotective (reducing infarct size) effects are associated with the activation of Shp-2 pathways which are associated with the inhibition of depression in an animal model.
Some researchers suggested that antidepressant activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitters system, and cognitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system...
Moreover, the study also showed that AR may be used as food and have potential drug-drug, drug-food, and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending a message between neurons, induced protective activities against the development of depression.
These results suggested that asparagus ameliorated depression with its neuroprotective effect by inhibited free radical that cause neuro cells damage and improved cell signal response.
However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of asparagus anti-depression possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)
(5) Effect of traditional Chinese exercise on the quality of life and depression for chronic diseases: a meta-analysis of randomised trials by Wang X1,2, Pi Y3, Chen B1, Chen P1, Liu Y4, Wang R4, Li X1, Zhu Y5, Yang Y6, Niu Z(PubMed)
(6) The 'extreme' side-effects of antidepressants By Lesley Ashmall
Tuesday, October 13, 2020
Fennel, The Functional Herb Which Processes Anxiolytic Property Similar to Those of Diazepam with No Adverse Effects, Scientists Find
Fennel may have a therapeutic effect in reducing the risk and treatment of anxiety, some scientists suggested.
Anxiety is a psychological problem caused by significant feelings of anxiety and fear of the present and future events.
In conventional medicine, an anxiolytic also known as an antianxiety agent including buspirone (BuSpar), trazodone, venlafaxine, and several of the benzodiazepines, is a medication used to reduce physical and psychological symptoms of anxiety disorder.
Anxiety is caused by a combination of several factors. However, stress directly from all sources is considered a major cause of the disease.
Other causes of anxiety include the longterm use of illicit drugs, medication intake, and medical condition and diseases associated with reduced lung functioning
Although medication may be effective, however, short and long-term use can cause symptoms of nausea. nervousness, dizziness, reduced sexual desire, insomnia.
In severe cases, the medicine can also cause blurred vision. confusion, nightmare, and difficulty thinking or remembering.
If you are taking the above medicine, please make sure that you understand all the side effects.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the investigate of the anxiolytic activity of ethanolic extracts of Foeniculum vulgare fruit by elevated plus maze, rotarod, open field test, and hole board models, researchers found that application of fennel extracts in the does of100-200mg/kg exerts a significant anti-anxiolytic activity, similar to those of standard anxiolytic drugs diazepam (1mg/kg) without inducing intolerable adverse effects.
This result was observed by the increased number of entries and time spent in the open arm in the elevated plus-maze apparatus.
And, application the same doses also promoted a number of rearings, assisted rearing and number of square crossed viewed by an open field test.
Further analysis also discovered that of fennel extracts also processes a potent skeletal muscle relaxant effect assessed by rotarod.
Additionally, in the experiment of the elevated plus maze, rotarod, open field, and hole board used in the evaluation of the psychomotor performance and emotional aspects of rodents removed from their acclimatized cage and placed in an environment express anxiety and fear, application of fennel extract, researchers indicated that
* Fennel injection group decreases anxiety-related behavior to an open area.
* Treated rodents exhibit a significant increase in the number of open arm entries and rearings, time spent in the center and line crossing, and head dipping.
* Fennel extract-treated group also reduces numbers of time of falling through increased muscle relaxant and improved locomotor function.
These results not only are given the supports to the holistic use of fennel in the treatment of anxiety but also reconfirmed the efficacy of fennel extract in reducing levels of anxiety in tested rodents who were placed in the environment with an expression of anxiety and fear in the first study.
Truly, the viability of above is also reaffirmed by the study conducted by the Geethanjali College of pharmacy in adult Swiss albino male mice randomly divided into six groups (n = 6).
According to the results of the analysis of groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), groups III to VI received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, mice groups treated with 50, 100, and 200 and 400 mg/kg displayed a significant reduction of anxiety score through an expression of all tests, including elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and other various parameters in doses dependent manner.
Compared to a higher dose of 400 mg/kg and lower dose treatment group, the application of 100 and 200 mg/kg dose of fennel essential oil mice demonstrated a strong decrease in anxiety through increased percent number of entries and time spent in open arms.
Compared to other doses of the treatment group, the administration of 200 mg/kg dose significantly increased the number of squares crossed at the center in the OFT test.
Furthermore, although the injection of 100 and 200 mg/kg doses of the essential oil-treated mice showed a significant reduction of rearing compared to another group, only the 200 mg/kg dose of the oil expressed a statistically significant reduction in rearing compared with diazepam, the conventional medicine used for the treatment of anxiety.
The discovery in the study postulated that fennel essential oil may have a potential effect in reducing anxiety nonlinearly and doses dependently.
"Fennel extract may possess anxiolytic activity supporting its traditional claim about anxiolytic activity", reported in the 19th edition of Pharmacology and Pharmacotherapeutics by Sathodkar, Bhandarkar, and Rege.
Taken all together, there is no doubt that fennel extracts and essential oil may be considered a secondary therapeutic treatment compared to standard medicine in the treatment of anxiety.
However, the intake of fennel supplements should be taken with extreme care in the prevention of toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE IN MICE MODEL Research Article R. NAGA KISHORE by Cheeryal (V), Keesara (M), N. ANJANEYULU, M. NAGA GANESH AND N. SRAVYA(International (Journal of Pharmacy and Pharmaceutical Sciences)
(2) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Miraf Mesfin, Kaleab Asres, and Workineh Shibeshi(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Anxiety is a psychological problem caused by significant feelings of anxiety and fear of the present and future events.
In conventional medicine, an anxiolytic also known as an antianxiety agent including buspirone (BuSpar), trazodone, venlafaxine, and several of the benzodiazepines, is a medication used to reduce physical and psychological symptoms of anxiety disorder.
Anxiety is caused by a combination of several factors. However, stress directly from all sources is considered a major cause of the disease.
Other causes of anxiety include the longterm use of illicit drugs, medication intake, and medical condition and diseases associated with reduced lung functioning
Although medication may be effective, however, short and long-term use can cause symptoms of nausea. nervousness, dizziness, reduced sexual desire, insomnia.
In severe cases, the medicine can also cause blurred vision. confusion, nightmare, and difficulty thinking or remembering.
If you are taking the above medicine, please make sure that you understand all the side effects.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the investigate of the anxiolytic activity of ethanolic extracts of Foeniculum vulgare fruit by elevated plus maze, rotarod, open field test, and hole board models, researchers found that application of fennel extracts in the does of100-200mg/kg exerts a significant anti-anxiolytic activity, similar to those of standard anxiolytic drugs diazepam (1mg/kg) without inducing intolerable adverse effects.
This result was observed by the increased number of entries and time spent in the open arm in the elevated plus-maze apparatus.
And, application the same doses also promoted a number of rearings, assisted rearing and number of square crossed viewed by an open field test.
Further analysis also discovered that of fennel extracts also processes a potent skeletal muscle relaxant effect assessed by rotarod.
Additionally, in the experiment of the elevated plus maze, rotarod, open field, and hole board used in the evaluation of the psychomotor performance and emotional aspects of rodents removed from their acclimatized cage and placed in an environment express anxiety and fear, application of fennel extract, researchers indicated that
* Fennel injection group decreases anxiety-related behavior to an open area.
* Treated rodents exhibit a significant increase in the number of open arm entries and rearings, time spent in the center and line crossing, and head dipping.
* Fennel extract-treated group also reduces numbers of time of falling through increased muscle relaxant and improved locomotor function.
These results not only are given the supports to the holistic use of fennel in the treatment of anxiety but also reconfirmed the efficacy of fennel extract in reducing levels of anxiety in tested rodents who were placed in the environment with an expression of anxiety and fear in the first study.
Truly, the viability of above is also reaffirmed by the study conducted by the Geethanjali College of pharmacy in adult Swiss albino male mice randomly divided into six groups (n = 6).
According to the results of the analysis of groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), groups III to VI received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, mice groups treated with 50, 100, and 200 and 400 mg/kg displayed a significant reduction of anxiety score through an expression of all tests, including elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and other various parameters in doses dependent manner.
Compared to a higher dose of 400 mg/kg and lower dose treatment group, the application of 100 and 200 mg/kg dose of fennel essential oil mice demonstrated a strong decrease in anxiety through increased percent number of entries and time spent in open arms.
Compared to other doses of the treatment group, the administration of 200 mg/kg dose significantly increased the number of squares crossed at the center in the OFT test.
Furthermore, although the injection of 100 and 200 mg/kg doses of the essential oil-treated mice showed a significant reduction of rearing compared to another group, only the 200 mg/kg dose of the oil expressed a statistically significant reduction in rearing compared with diazepam, the conventional medicine used for the treatment of anxiety.
The discovery in the study postulated that fennel essential oil may have a potential effect in reducing anxiety nonlinearly and doses dependently.
"Fennel extract may possess anxiolytic activity supporting its traditional claim about anxiolytic activity", reported in the 19th edition of Pharmacology and Pharmacotherapeutics by Sathodkar, Bhandarkar, and Rege.
Taken all together, there is no doubt that fennel extracts and essential oil may be considered a secondary therapeutic treatment compared to standard medicine in the treatment of anxiety.
However, the intake of fennel supplements should be taken with extreme care in the prevention of toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE IN MICE MODEL Research Article R. NAGA KISHORE by Cheeryal (V), Keesara (M), N. ANJANEYULU, M. NAGA GANESH AND N. SRAVYA(International (Journal of Pharmacy and Pharmaceutical Sciences)
(2) Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Miraf Mesfin, Kaleab Asres, and Workineh Shibeshi(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Saturday, October 10, 2020
Cranberry, the Best in Hyperglycemia Management Against Diabetics Complications
Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose.
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.
Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.
Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including high-fat diet and physical inactivity.
According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.
Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.
Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.
Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrolled diet, physical inactivity, miss-medication, and improper use of insulin injection.
Uncontrolled diabetes or hyperglycemia over the long-term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.
Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) have been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.
In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.
Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".
And, "With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.
In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.
Low levels of α-amylase have been found in patients with diabetes.
α-glucosidase is associated with the digestion of carbohydrates is elevated in patients with disbetes
According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders.
Furthermore, increased with increased dose (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.
At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.
Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.
Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".
Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.
Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.
Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including high-fat diet and physical inactivity.
According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.
Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.
Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.
Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrolled diet, physical inactivity, miss-medication, and improper use of insulin injection.
Uncontrolled diabetes or hyperglycemia over the long-term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.
Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) have been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.
In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.
Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".
And, "With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.
In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.
Low levels of α-amylase have been found in patients with diabetes.
α-glucosidase is associated with the digestion of carbohydrates is elevated in patients with disbetes
According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders.
Furthermore, increased with increased dose (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.
At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.
Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.
Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".
Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)
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