Fennel may be considered a functional food in exhibited liver protective effect against toxicity, some scientists suggested.
Liver protection in an action that prevents injury and damage of the liver, regardless of the causes.
Researchers do not know the exact cause of liver disease. However, they do know that genes inherited from the parents, aging and viral and bacterial infection are associated with the increased risk of liver disease.
Additionally, long-term excessive alcohol drinking and obesity are also some prevalent risk factors for the onset of liver disease.
Untreated liver disease or liver disease that is not treated properly overtime can increase the risk of cirrhosis, a leading cause of liver failure and a life-threatening condition.
Dr. William Nseir, the lead author in the assessment of the role of diet and lifestyle changes in nonalcoholic fatty liver disease wrote, "A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management. It is hard to maintain this mode of management; however, it seems to have significant long-term benefits" and "Furthermore, NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
These results suggested that a change of diet and lifestyle with moderate exercise may have a strong effect on the prevention of liver disease.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the evaluation of the liver protective effect against acute hepatotoxicity induced by carbon tetrachloride (CLL4) in the rat model, researchers found that oral administration of essential oil isolated from the fennel exerts a strong activity in the decrease of levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin, the potential causes of liver damage through their toxic effects.
Further analysis insisted that the hepatoprotective activity of the essential oil was attributed to the expression of phytochemical constituents d-limonene and β-myrcene in the inhibition of the levels of carbon tetrachloride in catalyzing liver toxicity and initiating liver lesion and liver fibrosis.
Additional differentiation of the hepatic fibrosis model in rats induced by subcutaneous injection with 40% CCl4 olive oil mixture with 94 male SD rats given high lipoid-low protein animal feeds for 5 weeks then randomly divided into six groups, including blank control group (A-group), 8 rats were feed in normal, prevention model control group (B-group), 10 rats given saline solution by intragastric administration during the make of hepatic fibrosis model and FVM prevention group (C-group), 10 rats given FVM by intragastric administration during make of hepatic fibrosis model; model control group (D-group), FVM treatment group (E-group) and Fuzhenghuayu treatment group (F-group), after assessing the results from the 5-th weekend, A, B, C- group rats sacrificed at the 6-th, 7-th, 8-th, 9-th weekend and 4-6 rats in D, E, F-group sacrificed., researchers indicated that
* The expression of alpha-smooth muscle actin(a-SMA) associated with liver damage and correlated positively in recurrent HCV hepatitis group are significantly higher in the HBV cirrhosis detected by immunohistochemical staining assay.
* Serum alanine aminotransferase (ALT), an amino acid found in proteins and intermediate in cellular energy production presented in the blood of tested subjects may be an indication of liver damage.
Low levels of ALT are found in the blood profiles of healthy individuals.
* Similar to ALT, aspartate aminotransferase (AST) is an enzyme associated with the liver parenchymal cell and presented in low levels in the blood of healthy individual but significantly higher in liver damage tested rats.
* Hyaluronic acid (HA) is distributed widely throughout connective, epithelial, and neural tissues, the prediction of liver damage, particularly in the risk of liver fibrosis.
* Increased levels of Laminin (LN), a protein of the extracellular matrix, are also associated with substantial risk with the development of liver fibrosis.
* Overexpression of levels of 8 - hydroxy-2-deoxyguanosine (8-OHdG) is another indication of oxidative stress and also considered as a critical biomarker of carcinogenesis.
The increased levels of the above expressions suggested substantial damage to the liver caused by ingestion of CCL4 in the non-fennel treatment group
However, the application of fennel in such groups inhibited the overexpression of toxicity caused by the injection of CCL4 by restoring the normal levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN), and 8 - hydroxy-2-deoxyguanosine (8-OHdG).
Further analysis also showed that oral administration of fennel inhibited the levels of malondialdehyde (MDA) in precipitated oxidative stress through lipid peroxidation.
Some researchers suggested that levels of MDA may be used as a biomarker in the assessment of oxidative stress status in patients with liver disease or cancer.
Moreover, injection of fennel exerted liver protective and anti-inflammatory effects through its antioxidants overexpression and improved production of natural antioxidants in the host tissue such as superoxide dismutase (SOD), glutathione peroxidase levels in inhibited oxidative stress initiated by CCL4
Precisely, fennel significantly decreased expression serums of ALT, AST, HA, and LN and MDA, 8-OHdG, fiber, and a-SMA expression in the FVM group and lowered inflammation grade and fibrosis stage compared to the control group.
Dr. Zhang ZG, the lead authors, after taking into account other co-founders said, "Foeniculum Vulgare Mill declines liver inflammation response, and prevent the hepatic fibrosis progression,, this may be due to its effects of antioxidative results".
The findings suggested that fennel with abundant bioactive anethole may be considered a functional food in exhibited hepatoprotective effect through its anti-inflammatory and antioxidants activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of Foeniculum vulgare essential oil by Ozbek H1, Uğraş S, Dülger H, Bayram I, Tuncer I, Oztürk G, Oztürk A.(PubMed)
(2) [Antioxidant effects of the Uygur herb, Foeniculum Vulgare Mill, in a rat model of hepatic fibrosis].[Article in Chinese] by Zhang ZG1, Lu XB, Xiao L, Tang L, Zhang LJ, Zhang T, Zhan XY, Ma XM, Zhang YX(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Friday, March 5, 2021
Thursday, March 4, 2021
Cranberry, Inhibits the Progression of Chronic Kidney Disease (CKD)
The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney dysfunction reduces the body's ability to clean and filter extra water from your blood, leading to fluid retention and high blood pressure in the early stage. Believe it or not, people with a kidney function of 10% do not show signs of kidney dysfunction and symptoms.
In other words, kidney disease often has no symptoms until at a very advanced stage.
Chronic kidney disease is a gradual loss of kidney function over time. Chronic kidney failure is the end stage of chronic kidney disease which has been found in a high number of patients with diabetes, high blood pressure, and other disorders.
Acute kidney dysfunction or acute kidney failure is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidney dysfunction can be cured if the causes are found.
Most cases of acute kidney dysfunction may be associated with toxin accumulated in the kidney organs, leading to the condition of nephrotoxicity.
Nephrotoxicity is a condition of kidney function caused by exposure to toxic chemicals or overdose of certain medications.
Some researchers suggested that people with diabetes are at an increased risk of chronic kidney disease, particularly in those with hyperglycemia.
The National Kidney Foundation wrote, "Diabetes is the leading cause of kidney failure, accounting for 44% percent of new cases. Current research suggests that control of high blood pressure is a key factor in slowing this disease. The strict control of blood sugar levels and reduction of dietary protein intake is also important. Treatment to prevent diabetic kidney disease should begin early — before kidney damage develops".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of renal disease, researchers examined the effect of Vaccinium macrocarpon (Dandelion)and Taraxacum officinale (Cranberry) on spontaneous feline chronic kidney disease.
The study included 34 neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) containing 60-80% hydrolyzed proteins, 20-40% minerals and active substances (Lespedeza spp. 0.0588, Vaccinium macrocarpon 0.0371%, and Taraxacum officinale 0.0231%.) for 90 days.
According to tested analysis, both showed a significant effect on the reduced symptoms.
Cats that received the ND exerted a significant decrease in creatinine, blood urea nitrogen, total proteins, and aspartate aminotransferase. The elevated levels of the aforementioned parameters have been found persistently in patients with chronic kidney disease.
Furthermore, urine turbidity score, color score, and total proteins associated with the progression of CKD in cats that received the ND were also decreased substantially.
Collectively, researchers after taking other factors into account said, "An ND based on Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale improves key indicators of renal failure in cats affected by chronic kidney disease".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of CKD, particularly in the combination with dandelion and Lespedeza spp, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberries - potential benefits in patients with chronic kidney disease by de Almeida Alvarenga L 1, Borges NA, Moreira LSG, Resende Teixeira KT, Carraro-Eduardo JC, Dai L, Stenvinkel P, Lindholm B, Mafra D. (PubMed)
(2) A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease by Di Cerbo A1,2, Iannitti T3, Guidetti G4, Centenaro S4, Canello S5, Cocco R. (PubMed)
(3) DIABETES AND CHRONIC KIDNEY DISEASE by The National Kidney Foundation
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney dysfunction reduces the body's ability to clean and filter extra water from your blood, leading to fluid retention and high blood pressure in the early stage. Believe it or not, people with a kidney function of 10% do not show signs of kidney dysfunction and symptoms.
In other words, kidney disease often has no symptoms until at a very advanced stage.
Chronic kidney disease is a gradual loss of kidney function over time. Chronic kidney failure is the end stage of chronic kidney disease which has been found in a high number of patients with diabetes, high blood pressure, and other disorders.
Acute kidney dysfunction or acute kidney failure is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidney dysfunction can be cured if the causes are found.
Most cases of acute kidney dysfunction may be associated with toxin accumulated in the kidney organs, leading to the condition of nephrotoxicity.
Nephrotoxicity is a condition of kidney function caused by exposure to toxic chemicals or overdose of certain medications.
Some researchers suggested that people with diabetes are at an increased risk of chronic kidney disease, particularly in those with hyperglycemia.
The National Kidney Foundation wrote, "Diabetes is the leading cause of kidney failure, accounting for 44% percent of new cases. Current research suggests that control of high blood pressure is a key factor in slowing this disease. The strict control of blood sugar levels and reduction of dietary protein intake is also important. Treatment to prevent diabetic kidney disease should begin early — before kidney damage develops".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of renal disease, researchers examined the effect of Vaccinium macrocarpon (Dandelion)and Taraxacum officinale (Cranberry) on spontaneous feline chronic kidney disease.
The study included 34 neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) containing 60-80% hydrolyzed proteins, 20-40% minerals and active substances (Lespedeza spp. 0.0588, Vaccinium macrocarpon 0.0371%, and Taraxacum officinale 0.0231%.) for 90 days.
According to tested analysis, both showed a significant effect on the reduced symptoms.
Cats that received the ND exerted a significant decrease in creatinine, blood urea nitrogen, total proteins, and aspartate aminotransferase. The elevated levels of the aforementioned parameters have been found persistently in patients with chronic kidney disease.
Furthermore, urine turbidity score, color score, and total proteins associated with the progression of CKD in cats that received the ND were also decreased substantially.
Collectively, researchers after taking other factors into account said, "An ND based on Lespedeza spp., Vaccinium macrocarpon, and Taraxacum officinale improves key indicators of renal failure in cats affected by chronic kidney disease".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of CKD, particularly in the combination with dandelion and Lespedeza spp, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberries - potential benefits in patients with chronic kidney disease by de Almeida Alvarenga L 1, Borges NA, Moreira LSG, Resende Teixeira KT, Carraro-Eduardo JC, Dai L, Stenvinkel P, Lindholm B, Mafra D. (PubMed)
(2) A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease by Di Cerbo A1,2, Iannitti T3, Guidetti G4, Centenaro S4, Canello S5, Cocco R. (PubMed)
(3) DIABETES AND CHRONIC KIDNEY DISEASE by The National Kidney Foundation
Wednesday, March 3, 2021
Herbal Dandelion(Taraxacum officinale) Processes Antiproliferative Activity Against Cancer
Cell proliferation is a radical growth of cells to replace the damage or injury through the cell cycle division.
Cell proliferation is a process and a necessary step for wound healing.
All normal cells undergo cell cycle division to replace the old cells with new cells through a limited cell division.
On the other hand, cancer cells can multiply definitely.
In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.
From the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.
A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.
The programmed cell death gene, such as BCL-2 induces cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.
In the phytochemicals perspective, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.
Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists compare five different common South European species of Taraxacum (T. obovatum (Willd.) DC., T. marginellum H. Lindb., T. hispanicum H. Lindb., T. lambinonii Soest and T. lacistrum Sahlin) antioxidant and anti-proliferative activity.
According to the dissimilarities between species in LC/MS patterns, T. marginellum demonstrated a strong intracellular antioxidant activity and cytotoxicity by reducing the expression of ROS.
Compared to the other 3 species, T. marginellum showed the most efficiency against the induction of free radicals overexpression in vitro.
Furthermore, in free radical theory, compared to T. marginellum, T. obovatum was the best free radical scavenger and a relevant cytotoxic effect was found in T. lacistrum extract over HeLa and HepG2 cell lines.
Taken altogether, Dandelion may be considered an antioxidant remedy that processes antioxidant and anti-proliferative activity, in a type-dependent manner, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity by Mingarro DM1, Plaza A, Galán A, Vicente JA, Martínez MP, Acero N. (PubMed)
Cell proliferation is a process and a necessary step for wound healing.
All normal cells undergo cell cycle division to replace the old cells with new cells through a limited cell division.
On the other hand, cancer cells can multiply definitely.
In cancer, antiproliferation is a process in which the cancer cells are killed or limited to grow through many mechanisms, including the use of chemo drugs.
From the immune perspective, anti-proliferation can be carried out by activating the genes associated with cancer suppression, programming cell death,.... and cell cycle arrest.
A suppressive gene, such as pro-apoptotic p53 induces cancer cell death through cell cycle arrest. In other words, the gene inhibits tumor growth by interrupting the cancer cell cycle division.
The programmed cell death gene, such as BCL-2 induces cell death by either inducing or inhibiting apoptosis. In other words, If cells are no longer needed or damaged, activating an intracellular death program will cause cell death.
In the phytochemicals perspective, anti-proliferation can also be carried out by antioxidants in which they stimulate the free radicals overexpression to induce toxicity to tumor cells without causing harm to the nearby healthy cells.
Some cancers can stimulate the production of a new blood vessel for cancer cells to grow and others can make enzymes that break down normal cells and tissues as they grow.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of chronic diseases, scientists compare five different common South European species of Taraxacum (T. obovatum (Willd.) DC., T. marginellum H. Lindb., T. hispanicum H. Lindb., T. lambinonii Soest and T. lacistrum Sahlin) antioxidant and anti-proliferative activity.
According to the dissimilarities between species in LC/MS patterns, T. marginellum demonstrated a strong intracellular antioxidant activity and cytotoxicity by reducing the expression of ROS.
Compared to the other 3 species, T. marginellum showed the most efficiency against the induction of free radicals overexpression in vitro.
Furthermore, in free radical theory, compared to T. marginellum, T. obovatum was the best free radical scavenger and a relevant cytotoxic effect was found in T. lacistrum extract over HeLa and HepG2 cell lines.
Taken altogether, Dandelion may be considered an antioxidant remedy that processes antioxidant and anti-proliferative activity, in a type-dependent manner, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of five Taraxacum species on in vitro and in vivo antioxidant and antiproliferative activity by Mingarro DM1, Plaza A, Galán A, Vicente JA, Martínez MP, Acero N. (PubMed)
Tuesday, March 2, 2021
Bromelain Enhances the Efficacy of Chemo Drug and Reduced Adverse Effects
Bromelain may have a strong effect in enhancing the chemo drug effect for the treatment of cancer, according to studies.
Chemo drugs are a group of medications used for the treatment of cancers that have been spread to other healthy tissues and organs or reduce the size of the tumor before removing it by surgery.
Cancer is a class of diseases caused by irregular cell growth in the organ tissues. The originated site where the cancer starts are considered primary cancer.
Most cancers at the advanced stage can induce secondary metastasis, by traveling a distance away from the primary site to infect other healthy tissues and organs.
Conventionally, the use of chemo drugs may be effective in controlling cancer, however, the medicines also have been found to cause significant side effects, including hair loss, easy bruising and bleeding, infection, anemia, and gastrointestinal discomforts such as nausea and vomiting and constipation, leading to reduce the quality of life of patients at the time of treatment.
According to the American Cancer Society, in the US, nearly 14.5 million children and adults with a history of cancer were alive on January 1, 2014.
Believe it or not, prostate (43%), colon and rectum (9%), and melanoma (8%) are the three most common cancers among male cancer survivors and breast (41%), uterine corpus (8%), and colon and rectum (8%) are the most common among female survivors.
Most cases of cancer can be treated successfully if diagnosed in the early stage. Some cancers such as breast cancer have a 5-year survival rate closed to 100% if diagnosed at the local stage.
As of today, due to unbearable side effects in some of the cancer patients, the scientific community is in urgency to discover plant compounds that can improve the chemo drugs' efficacy accompanied by reducing the adverse effect through dose reduction.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to discover a natural compound that enhances the chemo drug penetration for the treatment of cancer, researchers examined the antitumor properties of bromelain on hydrolyzing glycosidic linkages in faulty glycoprotein associated with cancer.
Injection of bromelain has been found to inhibit the MUC1, a glycoprotein involved in tumor cell invasion, metastasis, and chemo-resistant properties.
Additionally, bromelain enhanced the efficacy of cisplatin and 5-FU in cancer treatment by affecting the barrier function of MUC1.
Furthermore, bromelain protected the integrity and the viability of skin cells against the onset of malignant peritoneal mesothelioma (MPM) induced by the expression of MUC1.
Based on the results, researchers said, "current evidence indicates that bromelain may have the potential of being developed into an effective anticancer agent for MPM".
Moreover, also in malignant peritoneal mesothelioma (MPM), treatment with various concentrations of bromelain and after 4 and 72 h showed an adverse effect on the tested cancer cell through its antitumor activity in inducing cell death by apoptosis and autophagy.
Interestingly, the combinations of bromelain and cytotoxic drugs (cisplatin or 5-FU) assessed at 72 h showed a significant effect in inducing cytotoxicity compared to the bromelain treatment group.
These results suggested that bromelain may be combined with conventional chemo drugs to enhance the anti-cancer effect and reduce the adverse effect of chemotherapy in cancer patients.
Taken altogether, bromelain may be considered supplements for the enhancement of chemotherapy, and reduction of side effects, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma by Pillai K1, Akhter J, Chua TC, Morris DL. (PubMed)
(2) Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells by Pillai K1, Ehteda A, Akhter J, Chua TC, Morris DL. (PubMed)
(3) Estimated Numbers of Cancer Survivors by State as of January 1, 2014
Chemo drugs are a group of medications used for the treatment of cancers that have been spread to other healthy tissues and organs or reduce the size of the tumor before removing it by surgery.
Cancer is a class of diseases caused by irregular cell growth in the organ tissues. The originated site where the cancer starts are considered primary cancer.
Most cancers at the advanced stage can induce secondary metastasis, by traveling a distance away from the primary site to infect other healthy tissues and organs.
Conventionally, the use of chemo drugs may be effective in controlling cancer, however, the medicines also have been found to cause significant side effects, including hair loss, easy bruising and bleeding, infection, anemia, and gastrointestinal discomforts such as nausea and vomiting and constipation, leading to reduce the quality of life of patients at the time of treatment.
According to the American Cancer Society, in the US, nearly 14.5 million children and adults with a history of cancer were alive on January 1, 2014.
Believe it or not, prostate (43%), colon and rectum (9%), and melanoma (8%) are the three most common cancers among male cancer survivors and breast (41%), uterine corpus (8%), and colon and rectum (8%) are the most common among female survivors.
Most cases of cancer can be treated successfully if diagnosed in the early stage. Some cancers such as breast cancer have a 5-year survival rate closed to 100% if diagnosed at the local stage.
As of today, due to unbearable side effects in some of the cancer patients, the scientific community is in urgency to discover plant compounds that can improve the chemo drugs' efficacy accompanied by reducing the adverse effect through dose reduction.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
In the urgency to discover a natural compound that enhances the chemo drug penetration for the treatment of cancer, researchers examined the antitumor properties of bromelain on hydrolyzing glycosidic linkages in faulty glycoprotein associated with cancer.
Injection of bromelain has been found to inhibit the MUC1, a glycoprotein involved in tumor cell invasion, metastasis, and chemo-resistant properties.
Additionally, bromelain enhanced the efficacy of cisplatin and 5-FU in cancer treatment by affecting the barrier function of MUC1.
Furthermore, bromelain protected the integrity and the viability of skin cells against the onset of malignant peritoneal mesothelioma (MPM) induced by the expression of MUC1.
Based on the results, researchers said, "current evidence indicates that bromelain may have the potential of being developed into an effective anticancer agent for MPM".
Moreover, also in malignant peritoneal mesothelioma (MPM), treatment with various concentrations of bromelain and after 4 and 72 h showed an adverse effect on the tested cancer cell through its antitumor activity in inducing cell death by apoptosis and autophagy.
Interestingly, the combinations of bromelain and cytotoxic drugs (cisplatin or 5-FU) assessed at 72 h showed a significant effect in inducing cytotoxicity compared to the bromelain treatment group.
These results suggested that bromelain may be combined with conventional chemo drugs to enhance the anti-cancer effect and reduce the adverse effect of chemotherapy in cancer patients.
Taken altogether, bromelain may be considered supplements for the enhancement of chemotherapy, and reduction of side effects, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma by Pillai K1, Akhter J, Chua TC, Morris DL. (PubMed)
(2) Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells by Pillai K1, Ehteda A, Akhter J, Chua TC, Morris DL. (PubMed)
(3) Estimated Numbers of Cancer Survivors by State as of January 1, 2014
Monday, March 1, 2021
Fennel, the Functional Herb Which Processes Anti-antispasmodic Activity, Scientists Find
Fennel may have a potential and positive effect in reducing pain through its anti-antispasmodic property, some scientists suggested.
Anti-antispasmodic activity is an action that relieves, prevents, or lowers the incidence of muscle spasms, especially those of adnominal muscle in the uterus and smooth muscle such as in the bowel wall.
Certain hormones which have the function in controlling muscle contraction and relaxation are found to associate with the intensity of muscle spasms, if overexpressed.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the findings, the natural antispasmodic ingredients with little or no side effects, Dr. Shamkant B. Badgujar, and colleagues launched an investigation to compare doses of 2.5 and 10.0 mL/L of an alcoholic extract with other Germanic medicinal plants, including Melissa officinalis, Rosmarinus officinalis, Mentha piperita, Matricaria chamomilla, Carum carvi, and Citrus aurantium.
The experiment was carried out on guinea pig ileum by using acetylcholine and histamine as spasmogens.
After taking into all account co and confounders account, researchers found that application tested doses of alcoholic extract of the fruits of Foeniculum vulgare exert a significant anti antispasmodic activity by inhibiting the acetylcholine and histamine-induced guinea pig ileal contractions.
Further analysis of the effects of n essential oil obtained from the fruits of Foeniculum vulgare at the doses of 25 μg/ and 10 μg/mL, researchers discovered that the injections also demonstrated the similar as of the extract but through the inhibition of hormone oxytocin and prostaglandin activities.
Oxytocin and prostaglandin are hormones with a function that causes contraction of the muscles of the uterus. Over contraction of muscles of the uterus is a major cause of abdominal pain in women.
Additionally, the comparison of the antispasmodic property of 4 different herbal medicine that has been used in traditional medicine for the treatment of abdominal pain in Swiss mice, including fennel according to the guidelines of the Organization for Economic Co-operation and Development (OECD) also found that all herbs used in the testing display a substantial reduction of abdominal pain without inducing any adverse effects.
In the experiment carried out in the guinea pig, the application of fennel also showed significant relaxation in different agonists like histamine and acetylcholine-induced contractions in guinea-pig ileum.
Interestingly, in the study to investigate whether oral fennel drop has any effects in primary dysmenorrhea, the occurrence of painful menstrual cramps of the uterus, researchers conducted an experiment on sixty college students who suffer from primary dysmenorrhea.
The participants were randomly assigned to two groups and followed up for two cycles. The treatment group was given fennel drop and the control group was given non-steroidal anti-inflammatory drugs (NSAIDs) or oral contraceptive pills.
After assessing the final report, researchers suggested that both groups exert a clinically significant effect in reducing pain. However, the comparison of bleeding severity in the study group before and after the intervention on the first day, second day, the third day, the fourth day, and fifth day was 0.948, 0.330, 0.508, 0.583, 0.890, respectively.
Dr. Bokaie M, the lead scientist said, "fennel can be effective in reducing the severity of dysmenorrhea, but it has an unpleasant taste in view of most of the volunteers".
Taken all together, fennel may be considered a secondary and therapeutical form of treatment in reducing pain caused by overexpression of hormones that control the muscle contraction through its antispasmodic activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Spasmolytic effect of traditional herbal formulation on guinea pig ileum by Kumar D1, Ganguly K1, Hegde HV1, Patil PA2, Kholkute SD1(PubMed)
(3) Oral fennel (Foeniculum vulgare) drop effect on primary dysmenorrhea: Effectiveness of herbal drug by Bokaie M1, Farajkhoda T, Enjezab B, Khoshbin A, Karimi-Zarchi M(PubMed)
Anti-antispasmodic activity is an action that relieves, prevents, or lowers the incidence of muscle spasms, especially those of adnominal muscle in the uterus and smooth muscle such as in the bowel wall.
Certain hormones which have the function in controlling muscle contraction and relaxation are found to associate with the intensity of muscle spasms, if overexpressed.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the findings, the natural antispasmodic ingredients with little or no side effects, Dr. Shamkant B. Badgujar, and colleagues launched an investigation to compare doses of 2.5 and 10.0 mL/L of an alcoholic extract with other Germanic medicinal plants, including Melissa officinalis, Rosmarinus officinalis, Mentha piperita, Matricaria chamomilla, Carum carvi, and Citrus aurantium.
The experiment was carried out on guinea pig ileum by using acetylcholine and histamine as spasmogens.
After taking into all account co and confounders account, researchers found that application tested doses of alcoholic extract of the fruits of Foeniculum vulgare exert a significant anti antispasmodic activity by inhibiting the acetylcholine and histamine-induced guinea pig ileal contractions.
Further analysis of the effects of n essential oil obtained from the fruits of Foeniculum vulgare at the doses of 25 μg/ and 10 μg/mL, researchers discovered that the injections also demonstrated the similar as of the extract but through the inhibition of hormone oxytocin and prostaglandin activities.
Oxytocin and prostaglandin are hormones with a function that causes contraction of the muscles of the uterus. Over contraction of muscles of the uterus is a major cause of abdominal pain in women.
Additionally, the comparison of the antispasmodic property of 4 different herbal medicine that has been used in traditional medicine for the treatment of abdominal pain in Swiss mice, including fennel according to the guidelines of the Organization for Economic Co-operation and Development (OECD) also found that all herbs used in the testing display a substantial reduction of abdominal pain without inducing any adverse effects.
In the experiment carried out in the guinea pig, the application of fennel also showed significant relaxation in different agonists like histamine and acetylcholine-induced contractions in guinea-pig ileum.
Interestingly, in the study to investigate whether oral fennel drop has any effects in primary dysmenorrhea, the occurrence of painful menstrual cramps of the uterus, researchers conducted an experiment on sixty college students who suffer from primary dysmenorrhea.
The participants were randomly assigned to two groups and followed up for two cycles. The treatment group was given fennel drop and the control group was given non-steroidal anti-inflammatory drugs (NSAIDs) or oral contraceptive pills.
After assessing the final report, researchers suggested that both groups exert a clinically significant effect in reducing pain. However, the comparison of bleeding severity in the study group before and after the intervention on the first day, second day, the third day, the fourth day, and fifth day was 0.948, 0.330, 0.508, 0.583, 0.890, respectively.
Dr. Bokaie M, the lead scientist said, "fennel can be effective in reducing the severity of dysmenorrhea, but it has an unpleasant taste in view of most of the volunteers".
Taken all together, fennel may be considered a secondary and therapeutical form of treatment in reducing pain caused by overexpression of hormones that control the muscle contraction through its antispasmodic activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Spasmolytic effect of traditional herbal formulation on guinea pig ileum by Kumar D1, Ganguly K1, Hegde HV1, Patil PA2, Kholkute SD1(PubMed)
(3) Oral fennel (Foeniculum vulgare) drop effect on primary dysmenorrhea: Effectiveness of herbal drug by Bokaie M1, Farajkhoda T, Enjezab B, Khoshbin A, Karimi-Zarchi M(PubMed)
Sunday, February 28, 2021
9 Foods Stimulate the Over Growth of Fungus Candida, Scientists Suggest
Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.
Foods stimulated an overgrowth of fungus candida
1. Fruits and artificial ingredients
The high sugar content in fruit feeds Candida except for green apples, citrus, berries, and avocado(186)
and artificial ingredients can depress the immune system(187).
2. Aged cheese(188)
Candida famata found in aged cheese may induce invasive candidiasis(188).
3. Additive and preservation
Men made chemicals can disrupt the digestive track friendly bacteria and allow candida overgrowth(189)(190) such as citric acid. Non-organic food like meat or eggs can also contain antibiotics and steroids for faster growth(191).
4. Alcohol(192)
Alcohol can depress the liver(193) and the immune system(194)(195), causing overgrowth candida.
5. Caffeine, sugar, and sweetener
Caffeine(196)(197), sugar and sweetener(198) all harmful to the body and feed candida
6. Gluten
Gluten is a protein composite that appears in foods processed from wheat and related species
that can cause immune suppression(199)(200)(201).
7. Mushrooms
Mushroom which is the fleshy, spore-bearing fruiting body of a fungus, typically produced above ground on soil or on its food source can promote fungus overgrowth(202).
8. Condiments(203)
Condiment which is a sauce or seasoning added to food to impart a particular flavor can depress the immune system(204), causing candida.
9. Vinegar but not apple cider vinegar
Vinegar is an acidic liquid produced from the fermentation of ethanol in a process that yields its key ingredient, an acetic acid which can deplete the stomach of acids and cause inflammation(205)(206) in the digestive tract, including acetic acid ulcer(205).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possess additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(187) Top 4 Most Dangerous Artificial Sweeteners(Fit day)(188) Treatment of Candida famata bloodstream infections: case series and review of the literature. Beyda ND1, Chuang SH, Alam MJ, Shah DN, Ng TM, McCaskey L, Garey KW.(PubMed)
(189) Food Additives And Preservatives(All food business)
(190) Candida Albicans andFood Additives(Candida Albicans cure)(191) Antibiotics exposure, risk factors, and outcomes with Candidaalbicans and non-Candida albicans candidemia. Results from a multi-center study. Wang H1, Wu DW, Han H, Yue JF, Zhang F, Shan TC, Guo HP, Yin M.(PubMed)
(192) Candida and Alcohol Abuse (Holistic health talk)(193) Control of state 3 respiration in liver mitochondria from rats subjected to chronic ethanol consumption. Spach PI1, Cunningham CC. (PubMed)
(194) The associations of alcohol drinking and drinking cessation to measures of the immune system in middle-aged men. Mili F1, Flanders WD, Boring JR, Annest JL, DeStefano F.(PubMed)
(195) Acute immunomodulatory effects of binge alcohol ingestion. Afshar M1, Richards S2, Mann D3, Cross A4, Smith GB5, Netzer G6, Kovacs E7, Hasday J. (PubMed) (196) Recombinagenicity of caffeine for Candida albican . Sarachek A1, Henderson LA. (PubMed)
(197) Effects of growth temperature and caffeine on genetic responses of Candida albicans to ethyl methanesulfonate, nitrous acid, and ultraviolet radiation. Sarachek A, Bish JT. (PubMed)
(198) Sugar, Dairy, Artificial Sweeteners and Candida albicans Infections(Candida Diet Foods)(199) Immunomodulatory strategies for celiac disease. Rossi M1, Maurano F, Luongo D.(PubMed)
(200) The effect of diet on systemic immune responses to wheat gliadin.
Johnson RB, LaBrooy JT, Shearman DJ, Davidson GP. (PubMed)(201) In mice, gluten in maternaldiet primes systemic immune responses to gliadin in offspring.Troncone R1, Ferguson A.(PubMed)(202) [Virulence of the opportunistic pathogen mushroom Candidaglabrata].[Article in Spanish] Castaño I1, Cormack B, De Las Peñas A.(PubMed)
(203) Condiments and the Candida Diet(Jiangsu, Shihuan bioengineer company)(204) Immunomodulation of mast cells by nutrients. Hagenlocher Y1, Lorentz A2. (PubMed)
(205) Effect of hypoxia on acetic acid ulcer of the stomach in rats with or without coenzyme Q10.
Kohli Y, Suto Y, Kodama T.(PubMed)
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.
Foods stimulated an overgrowth of fungus candida
1. Fruits and artificial ingredients
The high sugar content in fruit feeds Candida except for green apples, citrus, berries, and avocado(186)
and artificial ingredients can depress the immune system(187).
2. Aged cheese(188)
Candida famata found in aged cheese may induce invasive candidiasis(188).
3. Additive and preservation
Men made chemicals can disrupt the digestive track friendly bacteria and allow candida overgrowth(189)(190) such as citric acid. Non-organic food like meat or eggs can also contain antibiotics and steroids for faster growth(191).
4. Alcohol(192)
Alcohol can depress the liver(193) and the immune system(194)(195), causing overgrowth candida.
5. Caffeine, sugar, and sweetener
Caffeine(196)(197), sugar and sweetener(198) all harmful to the body and feed candida
6. Gluten
Gluten is a protein composite that appears in foods processed from wheat and related species
that can cause immune suppression(199)(200)(201).
7. Mushrooms
Mushroom which is the fleshy, spore-bearing fruiting body of a fungus, typically produced above ground on soil or on its food source can promote fungus overgrowth(202).
8. Condiments(203)
Condiment which is a sauce or seasoning added to food to impart a particular flavor can depress the immune system(204), causing candida.
9. Vinegar but not apple cider vinegar
Vinegar is an acidic liquid produced from the fermentation of ethanol in a process that yields its key ingredient, an acetic acid which can deplete the stomach of acids and cause inflammation(205)(206) in the digestive tract, including acetic acid ulcer(205).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possess additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(187) Top 4 Most Dangerous Artificial Sweeteners(Fit day)(188) Treatment of Candida famata bloodstream infections: case series and review of the literature. Beyda ND1, Chuang SH, Alam MJ, Shah DN, Ng TM, McCaskey L, Garey KW.(PubMed)
(189) Food Additives And Preservatives(All food business)
(190) Candida Albicans andFood Additives(Candida Albicans cure)(191) Antibiotics exposure, risk factors, and outcomes with Candidaalbicans and non-Candida albicans candidemia. Results from a multi-center study. Wang H1, Wu DW, Han H, Yue JF, Zhang F, Shan TC, Guo HP, Yin M.(PubMed)
(192) Candida and Alcohol Abuse (Holistic health talk)(193) Control of state 3 respiration in liver mitochondria from rats subjected to chronic ethanol consumption. Spach PI1, Cunningham CC. (PubMed)
(194) The associations of alcohol drinking and drinking cessation to measures of the immune system in middle-aged men. Mili F1, Flanders WD, Boring JR, Annest JL, DeStefano F.(PubMed)
(195) Acute immunomodulatory effects of binge alcohol ingestion. Afshar M1, Richards S2, Mann D3, Cross A4, Smith GB5, Netzer G6, Kovacs E7, Hasday J. (PubMed) (196) Recombinagenicity of caffeine for Candida albican . Sarachek A1, Henderson LA. (PubMed)
(197) Effects of growth temperature and caffeine on genetic responses of Candida albicans to ethyl methanesulfonate, nitrous acid, and ultraviolet radiation. Sarachek A, Bish JT. (PubMed)
(198) Sugar, Dairy, Artificial Sweeteners and Candida albicans Infections(Candida Diet Foods)(199) Immunomodulatory strategies for celiac disease. Rossi M1, Maurano F, Luongo D.(PubMed)
(200) The effect of diet on systemic immune responses to wheat gliadin.
Johnson RB, LaBrooy JT, Shearman DJ, Davidson GP. (PubMed)(201) In mice, gluten in maternaldiet primes systemic immune responses to gliadin in offspring.Troncone R1, Ferguson A.(PubMed)(202) [Virulence of the opportunistic pathogen mushroom Candidaglabrata].[Article in Spanish] Castaño I1, Cormack B, De Las Peñas A.(PubMed)
(203) Condiments and the Candida Diet(Jiangsu, Shihuan bioengineer company)(204) Immunomodulation of mast cells by nutrients. Hagenlocher Y1, Lorentz A2. (PubMed)
(205) Effect of hypoxia on acetic acid ulcer of the stomach in rats with or without coenzyme Q10.
Kohli Y, Suto Y, Kodama T.(PubMed)
Friday, February 26, 2021
Herbal Angelica Sinensis, A Promising Anti-Glioblastoma Drug
Cancers are the class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that start on the inner lining of the tissue of an organ due to the alternation of cell DNA.
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluids circulation.
Glioblastoma is one of the most aggressive cancers that begins within the brain, caused mostly by abnormal astrocytic cells and dead cells (necrosis). The disease is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.
If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.
However, most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
Furthermore, the condition also shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of Angelica Sinensis on glioblastoma multiforme (GBM).
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis, Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways, including
* Biochemical stress associated with cell death such as oxidative stress in the induction of cytotoxicity.
* Induced DNA damage to the cancer cells by enhancing the tumor suppressor protein such as p53.
* Lack of growth factors involved in cell proliferative and differentiation.
Based on the results, researchers suggest, "our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathways solving pending problems such as reducing toxicity and side effect".
Taken altogether, Dandelion may be considered a remedy for the treatment of glioblastoma multiforme (GBM). pending the confirmation of the larger sample size and multicenter human study.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs by Park MN1, Song HS2, Kim M1, Lee MJ1, Cho W1, Lee HJ1, Hwang CH1, Kim S1, Hwang Y1, Kang B1, Kim B. (PubMed)
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluids circulation.
Glioblastoma is one of the most aggressive cancers that begins within the brain, caused mostly by abnormal astrocytic cells and dead cells (necrosis). The disease is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.
If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.
However, most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
Furthermore, the condition also shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
On finding a natural ingredient for the prevention and treatment of neurological diseases, scientists examined the effects of Angelica Sinensis on glioblastoma multiforme (GBM).
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis, Angelica sinensis accelerates apoptosis by their key substances influencing factors of apoptosis pathways, including
* Biochemical stress associated with cell death such as oxidative stress in the induction of cytotoxicity.
* Induced DNA damage to the cancer cells by enhancing the tumor suppressor protein such as p53.
* Lack of growth factors involved in cell proliferative and differentiation.
Based on the results, researchers suggest, "our review puts emphasis on the potential of natural products in GBM treatment by regulating multiple malignant cancer-related pathways solving pending problems such as reducing toxicity and side effect".
Taken altogether, Dandelion may be considered a remedy for the treatment of glioblastoma multiforme (GBM). pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs by Park MN1, Song HS2, Kim M1, Lee MJ1, Cho W1, Lee HJ1, Hwang CH1, Kim S1, Hwang Y1, Kang B1, Kim B. (PubMed)
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