A neuroprotective effect is an event that protects the central nervous system (CNS) by relatively preserving the neuronal structure and/or function.
Neurological diseases are the medical conditions of CNS disorder. Anything that involves the structural, biochemical or electrical abnormalities in the brain, spinal cord or other nerves, including brain damage are considered as neuro diseases.
The most common neurodegenerative diseases in the elderly are dementia. Depending on the brain regions that are damaged or dysfunctional, dementia can be Parkinson's, Alzheimer's, and Huntington's disease.
There are many risk factors involved in the incidence of neurological disorders, including unhealthy lifestyle, infections, genetics preposition, and physical injury.
Genetic mutation inherited from parents such as the NOTCH3 gene is the most common autosomal dominant inherited that causes stroke and vascular dementia.
Oxidative stress is a result of an imbalance of the ratio of levels of free radicals and antioxidants caused either by overexpression of free radicals or depletion of antioxidant enzymes or both.
Free radicals can be produced internally by normal cellular metabolism or from external sources such as the air we breathe, smoking. Free radicals are unstable molecules with unpaired electrons on the outer ring.
In order for them to maintain stable, free radicals must either donate an electron or intercept an electron from other atoms, leading to a chain reaction that can not be stopped until the outer ring electron is paired or inhibited by antioxidants.
Oxidative stress has been found to be a major risk for the onset of neurological disorders in the Western world, particularly in North American.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a natural compound for the treatment of neurological diseases, the researchers examined the effects of Ligustilide (LIG) is a principal active ingredient of Radix Angelica Sinensis on neuroprotective activity/
The aging model mice induced by subcutaneous (S.C.) injection of d-gal once daily for 8 weeks following by LIG (80 mg/kg) were simultaneously administered orally.
Based on the experimental results,* LIG administration markedly improved the behavioral performance of d-gal treated mice.
* LIG reduced the level of neuron stress markers MDA and increased the activity of Na(+)-K(+)-ATPase in the promotion of neurophysiology in the brain of d-gal induced aging mice.
* Moreover, LIG significantly raised the expression of GAP-43 associated with the development and axonal regeneration and reduced cleaved caspase-3 to promote cell death and GFAP levels in brain injury in the brain of d-gal treated mice.
Collectively, researchers said, "These results demonstrated that LIG improves d-gal-induced cognitive dysfunction and brain toxicity, which suggests that LIG may be developed as a new medicine for the treatment of age-related conditions".
Taken altogether, Herbal Angelica may be considered a neuroprotective remedy, pending a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose induced aging mice brain by Li JJ1, Zhu Q2, Lu YP3, Zhao P3, Feng ZB3, Qian ZM4, Zhu L. (PubMed)
Friday, May 14, 2021
Monday, May 10, 2021
Cranberry Does Not Improve Urinary Infection in Patients with Multiple Sclerosis
Urinary incontinence, a medical, psychological, social, economic, and hygienic problem, is a condition of loss of the bladder to control that can lead to a mild or severe form of involuntary leakage of urine.
Involuntary urine leakage or urinary incontinence is frequent among elderly women, adult women, even among adolescent women.
According to the statistics provided by Phoenix Physical Therapy, approximately 25 million adult Americans are living with some form of urinary incontinence of which 75-80% are women.
Believe it or not, about 17% of women and 16% of men over 18 years old have overactive bladder(OAB) and an estimated 12.2 million adults have urge incontinence.
All types of urinary incontinence have been found to have a negative impact on the quality of life and daily activity.
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system) caused by the immune system attacks the protective sheath (myelin) that covers nerve fibers.
MS causes communication problems between the brain and the rest of the body.
SHARON BEGLEY in examing the genetic preposition involved in MS wrote, " A newly discovered genetic mutation gives people who carry it a whopping 70 percent chance of developing multiple sclerosis, potentially opening the way toward new therapies for a debilitating neurological disorder whose ultimate cause has stumped researchers for decades".
The author continued, "The 70 percent chance of developing MS compares to a 0.1 percent risk in the general population, and the 100 or so previously known genetic variants increase the chance of MS to only about 0.3 percent at most, with no single gene packing much of a punch".
In other words, people having certain genes inherited from the parent are at a substantial risk of MS developing comapred to people who do not.
According to the statistics, in 2010/2011, approximately 93,500 Canadians were diagnosed with the disease or 290 cases per 100,000 population. Believe it or not, MS is the most prevalent in Canada comapred to other parts of the world.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia.
Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the improvement of the quality of life in cancer patients, researchers examined the cranberry extract on multiple sclerosis (MS) patients suffering from urinary disorders.
The cranberry versus placebo, prospective, double-blind study included a total of 171 adult MS outpatients with urinary disorders presenting at eight centers were randomized to cranberry extract (36 mg proanthocyanidins per day) or matching placebo received twice daily for 1 year.
According to the results at follow-up, there was no difference between cranberry and placebo.
Furthermore, there was no difference in time to first symptomatic UTI distribution across 1 year, with an estimated hazard ratio of 0.99, 95% CI [0.61, 1.60] (p = 0.97).
Moreover, secondary endpoints and tolerance did not differ between groups.
Based on the findings, researchers said, "Taking cranberry extract versus placebo twice a day did not prevent UTI occurrence in MS patients with urinary disorders".
Taken altogether, cranberry does not improve the urinary disorders in patients with MS, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry versus placebo in the prevention of urinary infections in multiple sclerosis: a multicenter, randomized, placebo-controlled, double-blind trial by Gallien P1, Amarenco G2, Benoit N3, Bonniaud V4, Donzé C5, Kerdraon J6, de Seze M7, Denys P8, Renault A9, Naudet F10, Reymann JM. (PubMed)
Involuntary urine leakage or urinary incontinence is frequent among elderly women, adult women, even among adolescent women.
According to the statistics provided by Phoenix Physical Therapy, approximately 25 million adult Americans are living with some form of urinary incontinence of which 75-80% are women.
Believe it or not, about 17% of women and 16% of men over 18 years old have overactive bladder(OAB) and an estimated 12.2 million adults have urge incontinence.
All types of urinary incontinence have been found to have a negative impact on the quality of life and daily activity.
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system) caused by the immune system attacks the protective sheath (myelin) that covers nerve fibers.
MS causes communication problems between the brain and the rest of the body.
SHARON BEGLEY in examing the genetic preposition involved in MS wrote, " A newly discovered genetic mutation gives people who carry it a whopping 70 percent chance of developing multiple sclerosis, potentially opening the way toward new therapies for a debilitating neurological disorder whose ultimate cause has stumped researchers for decades".
The author continued, "The 70 percent chance of developing MS compares to a 0.1 percent risk in the general population, and the 100 or so previously known genetic variants increase the chance of MS to only about 0.3 percent at most, with no single gene packing much of a punch".
In other words, people having certain genes inherited from the parent are at a substantial risk of MS developing comapred to people who do not.
According to the statistics, in 2010/2011, approximately 93,500 Canadians were diagnosed with the disease or 290 cases per 100,000 population. Believe it or not, MS is the most prevalent in Canada comapred to other parts of the world.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia.
Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the improvement of the quality of life in cancer patients, researchers examined the cranberry extract on multiple sclerosis (MS) patients suffering from urinary disorders.
The cranberry versus placebo, prospective, double-blind study included a total of 171 adult MS outpatients with urinary disorders presenting at eight centers were randomized to cranberry extract (36 mg proanthocyanidins per day) or matching placebo received twice daily for 1 year.
According to the results at follow-up, there was no difference between cranberry and placebo.
Furthermore, there was no difference in time to first symptomatic UTI distribution across 1 year, with an estimated hazard ratio of 0.99, 95% CI [0.61, 1.60] (p = 0.97).
Moreover, secondary endpoints and tolerance did not differ between groups.
Based on the findings, researchers said, "Taking cranberry extract versus placebo twice a day did not prevent UTI occurrence in MS patients with urinary disorders".
Taken altogether, cranberry does not improve the urinary disorders in patients with MS, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry versus placebo in the prevention of urinary infections in multiple sclerosis: a multicenter, randomized, placebo-controlled, double-blind trial by Gallien P1, Amarenco G2, Benoit N3, Bonniaud V4, Donzé C5, Kerdraon J6, de Seze M7, Denys P8, Renault A9, Naudet F10, Reymann JM. (PubMed)
Saturday, May 8, 2021
Herbal Turmeric, he Natural Prevention and Treatment of Type 2 Diabetes
Type II diabetes is an acquired chronic and medical condition caused by insufficiency of insulin entering the bloodstream, leading to abnormally high blood glucose.
In other words, type II diabetes developing is due to the pancreas not producing enough insulin caused by the loss of beta cells or the body does not properly use the insulin it makes as a result of insulin receptor sites clogged up by fat or cholesterol.
Although type II diabetes is a disease associated with adult-onset, today, the condition has been diagnosed in children at an alarming rate due to childhood obesity.
The most common symptoms of type II diabetes are increased thirst, frequent urination, unintended weight loss, fatigue.
In severe cases, patients with type II diabetes also experience symptoms of slow-healing sores, frequent infections, blurred vision.
Untreated type II diabetes may induce complications of diabetic retinopathy, kidney disease (nephropathy), diabetic neuropathy, and macrovascular problems.
As of today, there is no single cause and cure for type 2 diabetes. However, researchers suggested overweight, family history, aging, race, and medical conditions of prediabetes and gestational diabetes are some prevalent factors associated with the increased risk of the disease.c
Some researchers suggested that type 2 diabetes may be correlated to the promotion of the Western diet over the past few decades.
Dr. David Hefner in the article "Western Diet Linked to Type 2 Diabetes", wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains, and desserts-may increase your chances for Type 2 diabetes".
And, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
In other words, if you are following a high-fat diet, you are at a higher risk of type II diabetes. is
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetes, researchers examined the effect of Curcumin (CUR; diferuloylmethane) in the increased oxidative stress and the proinflammatory state that contributes to the development and progression of the diseases.
Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and their clearance by antioxidant defense mechanisms.
Curcumin improved the function of hepatic glucose and lipid metabolism which was dysfunctioned in patients with T2DM.
In vitro, curcumin was found to induce the liver protective effect in the regulation of glucose and lipid metabolism.
Furthermore, curcumin exerted antidiabetic potential by ameliorating skeletal muscle insulin resistance in rodents with diet-induced insulin resistance via an increase of the uptake and oxidation of fatty acids.
Moreover, curcumin also found to improve insulin sensitivity in muscle tissue of insulin-resistant rodents by an increase of the cellular glucose uptake by enhancing the GLUT4 translocation.
In adipose tissue analysis, curcumin protected the adipose tissue function, by protecting the normal adipokine production, FFA release, and preventing inflammation, that is associated with the pathogenesis of T2DM.
In pancreatic β-cells differentiation, curcumin enhanced the pancreatic β-cell function under diabetic conditions.
On metabolic dysfunction, curcumin improved the glycemic status and insulin sensitivity demonstrated in high-fat-diet- (HFD-) fed C57BL/6J mice and C57BL/6J ob/ob mice.
More recently, curcumin exerted a positive effect of CUR on metabolic abnormalities associated with T2DM have been confirmed in high-fructose-fed Wistar rats by attenuating insulin resistance and glucose intolerance through its antioxidative and anti-inflammatory actions
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of type II diabetes, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Natural Products for the Treatment of Type 2 Diabetes Mellitus by Ríos JL1, Francini F2, Schinella GR. (PubMed)
(2) Molecular Mechanisms Underlying Curcumin-Mediated Therapeutic Effects in Type 2 Diabetes and Cancer by Wojcik M1, Krawczyk M1, Wojcik P2, Cypryk K3, Wozniak LA. (PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)
In other words, type II diabetes developing is due to the pancreas not producing enough insulin caused by the loss of beta cells or the body does not properly use the insulin it makes as a result of insulin receptor sites clogged up by fat or cholesterol.
Although type II diabetes is a disease associated with adult-onset, today, the condition has been diagnosed in children at an alarming rate due to childhood obesity.
The most common symptoms of type II diabetes are increased thirst, frequent urination, unintended weight loss, fatigue.
In severe cases, patients with type II diabetes also experience symptoms of slow-healing sores, frequent infections, blurred vision.
Untreated type II diabetes may induce complications of diabetic retinopathy, kidney disease (nephropathy), diabetic neuropathy, and macrovascular problems.
As of today, there is no single cause and cure for type 2 diabetes. However, researchers suggested overweight, family history, aging, race, and medical conditions of prediabetes and gestational diabetes are some prevalent factors associated with the increased risk of the disease.c
Some researchers suggested that type 2 diabetes may be correlated to the promotion of the Western diet over the past few decades.
Dr. David Hefner in the article "Western Diet Linked to Type 2 Diabetes", wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains, and desserts-may increase your chances for Type 2 diabetes".
And, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
In other words, if you are following a high-fat diet, you are at a higher risk of type II diabetes. is
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetes, researchers examined the effect of Curcumin (CUR; diferuloylmethane) in the increased oxidative stress and the proinflammatory state that contributes to the development and progression of the diseases.
Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and their clearance by antioxidant defense mechanisms.
Curcumin improved the function of hepatic glucose and lipid metabolism which was dysfunctioned in patients with T2DM.
In vitro, curcumin was found to induce the liver protective effect in the regulation of glucose and lipid metabolism.
Furthermore, curcumin exerted antidiabetic potential by ameliorating skeletal muscle insulin resistance in rodents with diet-induced insulin resistance via an increase of the uptake and oxidation of fatty acids.
Moreover, curcumin also found to improve insulin sensitivity in muscle tissue of insulin-resistant rodents by an increase of the cellular glucose uptake by enhancing the GLUT4 translocation.
In adipose tissue analysis, curcumin protected the adipose tissue function, by protecting the normal adipokine production, FFA release, and preventing inflammation, that is associated with the pathogenesis of T2DM.
In pancreatic β-cells differentiation, curcumin enhanced the pancreatic β-cell function under diabetic conditions.
On metabolic dysfunction, curcumin improved the glycemic status and insulin sensitivity demonstrated in high-fat-diet- (HFD-) fed C57BL/6J mice and C57BL/6J ob/ob mice.
More recently, curcumin exerted a positive effect of CUR on metabolic abnormalities associated with T2DM have been confirmed in high-fructose-fed Wistar rats by attenuating insulin resistance and glucose intolerance through its antioxidative and anti-inflammatory actions
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of type II diabetes, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Natural Products for the Treatment of Type 2 Diabetes Mellitus by Ríos JL1, Francini F2, Schinella GR. (PubMed)
(2) Molecular Mechanisms Underlying Curcumin-Mediated Therapeutic Effects in Type 2 Diabetes and Cancer by Wojcik M1, Krawczyk M1, Wojcik P2, Cypryk K3, Wozniak LA. (PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)
Wednesday, May 5, 2021
Herbal Coltsfoot(Tussilago farfara) Improves the Bone Marrow Cells Against the Risk of Leukemia
Leukemia is a condition characterized by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.
Bone marrow is the soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, leg. etc.
Acute leukemia is a condition caused by a rapid increase in the numbers of extreme immature white blood cells which appear in the bloodstream in the other parts of the body, including tissue and organs, Acute leukemia can also be classified into
* Acute lymphoblastic leukemia (ALL)
Acute lymphocytic leukemia (ALL) is a type of cancer of the abnormal growth of extremely immature lymphocytes overproduced by the bone marrow and/or lymphatic system. The condition has a tendency to multiply quickly, leading to the death of normal white blood cells in the bone marrow and/or lymphatic system.
In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia with about 80% of all cases.
* Acute myeloid leukemia (AML)
Acute myelogenous leukemia (AML) is a cancer of myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells. In AML, granulocytes appear immature in the bloodstream.
According to the statistic proved by the American Cancer Society, in 2019, approximately 21,450 new cases of acute myeloid leukemia (AML) will be diagnosed in adults. The disease also causes the
of 10,920 deaths of American adults.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of bone marrow cell integrity, researchers examined the protective effect of polysaccharides from Tussilago farfara L. on bone marrow cells.
According to the tested analysis, Tussilago farfara L. protected the bone marrow cells against the side effects of polychemotherapy-induced apoptosis.
Furthermore, polychemotherapy-induced DNA damage in bone marrow cells was also reversed by the application of polysaccharides from Tussilago farfara L.
In vivo, small intestinal epithelium of C57Bl/6 mice, polysaccharides from Tussilago farfara L.also induced genoprotective properties against the chemo side effects.
Taken altogether, coltsfoot may be considered a remedy for the protection of bone marrow cell integrity against the onset of leukemia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay by Safonova EA1, Lopatina KA2, Vychuzhanina AV2, Mashanova VA2, Razina TG2, Borovskaya TG2, Zueva EP2, Gur'ev AM3, Belousov MV. (PubMed)
Saturday, May 1, 2021
Cranberry Inhibits The Expression of Advanced Glycation (AD) Expression
Advanced glycation end is a by produces formed by protein or fat combine with sugar caused by cooking meat at high temperature.
The products have been found to affect metabolic health.
The most common causes of AGEs are from the diet, particularly in people who follow the Western diet with high saturated and trans fat, a lot of red meats, and processed foods.
Low levels of AGEs may not be a problem, however, overexpression of AGEs can induce oxidative stress, leading to inflammation and damage proteins, lipid, and sometimes alternation of cells DNA.
In other words, AGEs initiates the production and free radicals and free radical a chain reaction that can not be stopped until all electrons in the outer ring paired or inhibited by antioxidants.
Accelerated formation and accumulation of advanced glycation end-products have been found to increased hyperglycemia or oxidative stress, leading to age-related and chronic diseases such as diabetes mellitus, chronic renal failure, neurodegenerative diseases, osteoarthritis, and also non-diabetic atherosclerosis, and chronic heart failure.
Some researchers suggested that modern life byproducts of AGEs are the results of the promotion of the processed food diet.
Dr. Chetan Sharma, Amarjeet Kaur, the lead scientist in the assessment of AGEs, wrote, "As modern diets are largely heat-processed, they are more prone to contain high levels of advanced glycation end products (AGEs)".
And, "The chemistry of the AGEs formation, absorption and bioavailability and their patho-biochemistry particularly in relation to different complications like diabetes and aging,... The emerging evidence about the adverse effects of AGEs makes it necessary to investigate the different therapies to inhibit AGEs".
The results strongly suggested the link of the modern diet with highly processed food is a leading cause of chronic diseases.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of oxidative stress, researchers examined anti-glycation effects of several polyphenol-rich fruits, including blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts, which are rich in anthocyanins.
Berry crude extracts (CE) yielded anthocyanins-enriched (ACE) extracts used in the study, showed a significant effect against oxidative stress by exhibiting the free radical scavenging, reactive carbonyl species trapping, and anti-glycation effects compared to their respective ACFs.
Furthermore, the berry ACEs (at 100 μg/mL) inhibited both thermal- and MGO-induced Aβ fibrillation induced by the overexpression of glycation.
Moreover, the berry ACEs (at 20 μg/mL) also reduced H₂O₂-induced reactive oxygen species production and lipopolysaccharide-induced nitric oxide species in BV-2 microglia by decreasing H₂O₂-induced neuron cytotoxicity and caspase-3/7 activity in BV-2 microglia involved in inflammation.
Based on the findings, researchers said, "The free radical scavenging, reactive carbonyl trapping, anti-glycation, anti-Aβ fibrillation, and microglial neuroprotective effects of these berry extracts warrant further in vivo studies to evaluate their potential neuroprotective effects against AD".
Taken altogether, cranberry may be considered a remedy for the treatment of AD, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects by Ma H1,2,3, Johnson SL4,5, Liu W6, DaSilva NA7,8, Meschwitz S9, Dain JA10, Seeram NP. (PubMed)
The products have been found to affect metabolic health.
The most common causes of AGEs are from the diet, particularly in people who follow the Western diet with high saturated and trans fat, a lot of red meats, and processed foods.
Low levels of AGEs may not be a problem, however, overexpression of AGEs can induce oxidative stress, leading to inflammation and damage proteins, lipid, and sometimes alternation of cells DNA.
In other words, AGEs initiates the production and free radicals and free radical a chain reaction that can not be stopped until all electrons in the outer ring paired or inhibited by antioxidants.
Accelerated formation and accumulation of advanced glycation end-products have been found to increased hyperglycemia or oxidative stress, leading to age-related and chronic diseases such as diabetes mellitus, chronic renal failure, neurodegenerative diseases, osteoarthritis, and also non-diabetic atherosclerosis, and chronic heart failure.
Some researchers suggested that modern life byproducts of AGEs are the results of the promotion of the processed food diet.
Dr. Chetan Sharma, Amarjeet Kaur, the lead scientist in the assessment of AGEs, wrote, "As modern diets are largely heat-processed, they are more prone to contain high levels of advanced glycation end products (AGEs)".
And, "The chemistry of the AGEs formation, absorption and bioavailability and their patho-biochemistry particularly in relation to different complications like diabetes and aging,... The emerging evidence about the adverse effects of AGEs makes it necessary to investigate the different therapies to inhibit AGEs".
The results strongly suggested the link of the modern diet with highly processed food is a leading cause of chronic diseases.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of oxidative stress, researchers examined anti-glycation effects of several polyphenol-rich fruits, including blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts, which are rich in anthocyanins.
Berry crude extracts (CE) yielded anthocyanins-enriched (ACE) extracts used in the study, showed a significant effect against oxidative stress by exhibiting the free radical scavenging, reactive carbonyl species trapping, and anti-glycation effects compared to their respective ACFs.
Furthermore, the berry ACEs (at 100 μg/mL) inhibited both thermal- and MGO-induced Aβ fibrillation induced by the overexpression of glycation.
Moreover, the berry ACEs (at 20 μg/mL) also reduced H₂O₂-induced reactive oxygen species production and lipopolysaccharide-induced nitric oxide species in BV-2 microglia by decreasing H₂O₂-induced neuron cytotoxicity and caspase-3/7 activity in BV-2 microglia involved in inflammation.
Based on the findings, researchers said, "The free radical scavenging, reactive carbonyl trapping, anti-glycation, anti-Aβ fibrillation, and microglial neuroprotective effects of these berry extracts warrant further in vivo studies to evaluate their potential neuroprotective effects against AD".
Taken altogether, cranberry may be considered a remedy for the treatment of AD, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects by Ma H1,2,3, Johnson SL4,5, Liu W6, DaSilva NA7,8, Meschwitz S9, Dain JA10, Seeram NP. (PubMed)
Monday, April 26, 2021
Cranberry Improves Symptoms of Neuro-Psychology
Neuropsychological assessment provides both general and specific information about current levels of cognitive performance. An average or composite score across multiple ability areas provides an overall index of how well a person functions cognitively at the current time.
Cognition is the process of the brain functioning associated with the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision making.
Cognitive deficit is a medical condition, that affects a person's thinking, communication, understanding, or memory. The cognitive deficit can be acute or chronic.
Acute cognitive deficit is a short-term health problem caused by drug toxicity and withdrawal, electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensor input, intracranial urinary retention/fecal impaction, or myocardial/metabolic/pulmonary. An acute cognitive deficit may be recovered if the cause is found.
Chronic cognitive deficit is a permanent medical condition caused by the gradual or permanent loss of the neurons, leading to problems of language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.
There is no single cause of the chronic cognitive deficit. An increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, being obese, and lack of exercise are some prevalent factors found in patients with chronic cognitive deficit.
Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease such as brain change caused by the abnormal clumps of beta-amyloid protein (plaques).
Small strokes or reduced blood flow through the brain can also cause a chronic cognitive deficit.
According to the observation of the patient MRI, patients brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles), and reduced use of glucose, the sugar that's the primary source of energy for cells.
Out of many risk factors associated with the onset of the condition, obesity is also one of the major risk factors of cognitive impairment in the Western world.
Dr. Jason C. D. Nguyen, the lead author on the neurological team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of the neurological disorder, researchers examined the cranberry extract (CE) neuropsychologic effect.
The double-blind, placebo-controlled, randomized, parallel-group, clinical trial included 50 community-dwelling, cognitively intact volunteers, > or = 60 years old, who reported no history of dementia or significant neurocognitive impairments.
Participants in the study were randomly assigned to receive either 32 ounces/day of a beverage containing 27% cranberry juice per volume (n = 25) or placebo (n = 25) for 6 weeks.
According to the neuropsychologic tests before and after treatment on participants' self-reported, there was a nonsignificant trend (X2(1) = 2.373, p = 0.123) on overall abilities to remember.
However, more than twice of many participants (37.5%) reported the overall abilities to remember at the end of treatment compared to placebo controls (17.4%).
In other words, cranberry extract (CE) although can not improve overall neuropsychologic symptoms, it enhances the short-term memory of dementia or significant neurocognitive impairments.
Taken altogether, cranberry may be considered a remedy for the improvement of memory, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A double-blinded, placebo-controlled, randomized trial of the neuropsychologic efficacy of cranberry juice in a sample of cognitively intact older adults: pilot study findings by Crews WD Jr1, Harrison DW, Griffin ML, Addison K, Yount AM, Giovenco MA, Hazell J. (PubMed)
(2) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)
Cognition is the process of the brain functioning associated with the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision making.
Cognitive deficit is a medical condition, that affects a person's thinking, communication, understanding, or memory. The cognitive deficit can be acute or chronic.
Acute cognitive deficit is a short-term health problem caused by drug toxicity and withdrawal, electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensor input, intracranial urinary retention/fecal impaction, or myocardial/metabolic/pulmonary. An acute cognitive deficit may be recovered if the cause is found.
Chronic cognitive deficit is a permanent medical condition caused by the gradual or permanent loss of the neurons, leading to problems of language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.
There is no single cause of the chronic cognitive deficit. An increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, being obese, and lack of exercise are some prevalent factors found in patients with chronic cognitive deficit.
Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease such as brain change caused by the abnormal clumps of beta-amyloid protein (plaques).
Small strokes or reduced blood flow through the brain can also cause a chronic cognitive deficit.
According to the observation of the patient MRI, patients brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles), and reduced use of glucose, the sugar that's the primary source of energy for cells.
Out of many risk factors associated with the onset of the condition, obesity is also one of the major risk factors of cognitive impairment in the Western world.
Dr. Jason C. D. Nguyen, the lead author on the neurological team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of the neurological disorder, researchers examined the cranberry extract (CE) neuropsychologic effect.
The double-blind, placebo-controlled, randomized, parallel-group, clinical trial included 50 community-dwelling, cognitively intact volunteers, > or = 60 years old, who reported no history of dementia or significant neurocognitive impairments.
Participants in the study were randomly assigned to receive either 32 ounces/day of a beverage containing 27% cranberry juice per volume (n = 25) or placebo (n = 25) for 6 weeks.
According to the neuropsychologic tests before and after treatment on participants' self-reported, there was a nonsignificant trend (X2(1) = 2.373, p = 0.123) on overall abilities to remember.
However, more than twice of many participants (37.5%) reported the overall abilities to remember at the end of treatment compared to placebo controls (17.4%).
In other words, cranberry extract (CE) although can not improve overall neuropsychologic symptoms, it enhances the short-term memory of dementia or significant neurocognitive impairments.
Taken altogether, cranberry may be considered a remedy for the improvement of memory, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A double-blinded, placebo-controlled, randomized trial of the neuropsychologic efficacy of cranberry juice in a sample of cognitively intact older adults: pilot study findings by Crews WD Jr1, Harrison DW, Griffin ML, Addison K, Yount AM, Giovenco MA, Hazell J. (PubMed)
(2) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)
Saturday, April 17, 2021
Cranberry, the Best in Hyperglycemia Management Against Diabetics Complications
Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose.
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.
Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.
Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including a high-fat diet and physical inactivity.
According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.
Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.
Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.
Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrolled diet, physical inactivity, miss-medication, and improper use of insulin injection.
Uncontrolled diabetes or hyperglycemia over the long term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.
Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) have been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.
In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.
Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".
And, "With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.
In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.
Low levels of α-amylase have been found in patients with diabetes.
α-glucosidase is associated with the digestion of carbohydrates is elevated in patients with diabetes
According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders.
Furthermore, increased with increased dose (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.
At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.
Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.
Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".
Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)
The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.
Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.
Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including a high-fat diet and physical inactivity.
According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.
Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.
Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.
Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrolled diet, physical inactivity, miss-medication, and improper use of insulin injection.
Uncontrolled diabetes or hyperglycemia over the long term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.
Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) have been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.
In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.
Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".
And, "With aging, lower Sirt1 abundance and activity, increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.
In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.
Low levels of α-amylase have been found in patients with diabetes.
α-glucosidase is associated with the digestion of carbohydrates is elevated in patients with diabetes
According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders.
Furthermore, increased with increased dose (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.
At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.
Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.
Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".
Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)
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